Web Desc
Regulation of Lymphocyte Signaling
Organizer(s): Arthur Weiss and Bernard Malissen
Date: March 11 - 16, 2012
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Abbott Laboratories, Novo Nordisk A/S and Takeda Pharmaceutical Company Limited
Summary of Meeting:
Key individual components of signaling pathways that control lymphocyte activation have been identified. However, their specific regulation, integration within pathways and regulation are still the subject of intense investigation. Currently, they are being probed through biochemical, chemical-genetic, modeling and imaging methods. Major hurdles still reflect our very simplistic understanding of both the kinetic parameters of the molecules involved as well as the complexity of the regulatory circuits of these signaling pathways. Moreover, it is still quite difficult to translate such information into downstream biologically important information. The fact that therapeutics targeting these signaling pathways are still lagging is not surprising. The Keystone Symposia meeting on Regulation of Lymphocyte Signaling will highlight different methodologies and approaches aimed at developing a better integration of complex information about signaling. This information will lead to better understanding of how the normal immune system functions and where interventions in signaling pathways can be used in diseases of the immune system.
Scholarship Deadline: November 10 2011
Discounted Abstract Deadline: November 10 2011
Abstract Deadline: December 13 2011
Discounted Registration Deadline: January 12 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Abbott LaboratoriesNovo Nordisk A/STakeda Pharmaceutical Company Limited
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI098289-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 11 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, March 11 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Sunday, March 11 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Grays Peak

Speaker 2 of 2
Joseph Schlessinger, Yale University School of Medicine, USA
Cell Signaling by Receptor Tyrosine Kinases: From Basic Principles to Cancer Therapy

Sunday, March 11 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Grays Peak

Speaker 1 of 2
* Arthur Weiss, University of California, San Francisco, USA

Monday, March 12 | 7:00AM - 8:00AM
Breakfast
Room: Longs/Quandary Peaks


Monday, March 12 | 8:00AM - 11:15AM
Biochemistry and Systems Biology of TCR Signaling
Room: Grays Peak

Speaker 7 of 7
Garry P. Nolan, Stanford University, USA
Single Cell 'Phosphoflow' Analysis

Monday, March 12 | 8:00AM - 11:15AM
Biochemistry and Systems Biology of TCR Signaling
Room: Grays Peak

Speaker 6 of 7
Arup K. Chakraborty, Massachusetts Institute of Technology, USA
Role of the Membrane Environment in Regulating Early Events in TCR Signaling

Monday, March 12 | 8:00AM - 11:15AM
Biochemistry and Systems Biology of TCR Signaling
Room: Grays Peak

Speaker 5 of 7
Mira Barda-Saad, Bar Ilan University, Israel
Short Talk: Molecular Characterization of the WIP;WASp Complex Essential for Actin Polymerization: Insights from Triple-Color FRET Imaging Technology

Monday, March 12 | 8:00AM - 11:15AM
Biochemistry and Systems Biology of TCR Signaling
Room: Grays Peak

Speaker 4 of 7
Katharina Gaus, University of New South Wales, Australia
Short Talk: The Role of LAT Vesicles in T Cell Activation

Monday, March 12 | 8:00AM - 11:15AM
Biochemistry and Systems Biology of TCR Signaling
Room: Grays Peak

Speaker 3 of 7
Gary A. Koretzky, University of Pennsylvania School of Medicine, USA
Signaling Mutants Uncover Rare Populations of Innate-Like Lymphocytes

Monday, March 12 | 8:00AM - 11:15AM
Biochemistry and Systems Biology of TCR Signaling
Room: Grays Peak

Speaker 2 of 7
Arthur Weiss, University of California, San Francisco, USA
Regulation of Tyrosine Kinases by the TCR

Monday, March 12 | 8:00AM - 11:15AM
Biochemistry and Systems Biology of TCR Signaling
Room: Grays Peak

Speaker 1 of 7
* Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France

Monday, March 12 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 12 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, March 12 | 11:15AM - 1:00PM
Poster Setup
Room: Longs/Quandary Peaks


Monday, March 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs/Quandary Peaks


Monday, March 12 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 12 | 5:00PM - 7:00PM
BCR Signaling and Regulation
Room: Grays Peak

Speaker 5 of 5
Victor L.J. Tybulewicz, Francis Crick Institute, UK
Short Talk: The B Cell Antigen Receptor Transduces Signals from the BAFF Receptor Required for B Cell Survival

Monday, March 12 | 5:00PM - 7:00PM
BCR Signaling and Regulation
Room: Grays Peak

Speaker 4 of 5
Pavel Tolar, Francis Crick Institute, UK
Coordination of Signaling and Endocytosis in the B Cell Synapse

Monday, March 12 | 5:00PM - 7:00PM
BCR Signaling and Regulation
Room: Grays Peak

Speaker 3 of 5
Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Dysregulation of Self-Tolerance Checkpoints by Mutations in the Antigen Receptor - NF-kappaB Signaling Pathway

Monday, March 12 | 5:00PM - 7:00PM
BCR Signaling and Regulation
Room: Grays Peak

Speaker 2 of 5
Michael Reth, Albert-Ludwigs University Freiburg, Germany
Nanoscale Analysis of B Cell Antigen Receptor Activation

Monday, March 12 | 5:00PM - 7:00PM
BCR Signaling and Regulation
Room: Grays Peak

Speaker 1 of 5
* John C. Cambier, University of Colorado, USA

Monday, March 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks


Monday, March 12 | 7:30PM - 10:00PM
Poster Session 1
Room: Longs/Quandary Peaks


Tuesday, March 13 | 7:00AM - 8:00AM
Breakfast
Room: Longs/Quandary Peaks


Tuesday, March 13 | 8:00AM - 11:00AM
Imaging Signaling in Cells and in vivo
Room: Grays Peak

Speaker 1 of 6
* Tomohiro Kurosaki, Osaka University, Japan

Tuesday, March 13 | 8:00AM - 11:00AM
Imaging Signaling in Cells and in vivo
Room: Grays Peak

Speaker 2 of 6
Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging Immune Responses in Vivo

Tuesday, March 13 | 8:00AM - 11:00AM
Imaging Signaling in Cells and in vivo
Room: Grays Peak

Speaker 3 of 6
Stephen C. Bunnell, Tufts University School of Medicine, USA
Ubiquitin-Dependent Recruitment of IKKgamma/NEMO to TCR Microclusters during T Cell Activation

Tuesday, March 13 | 8:00AM - 11:00AM
Imaging Signaling in Cells and in vivo
Room: Grays Peak

Speaker 4 of 6
Jay T. Groves, University of California, Berkeley, USA
Patterned Spatial Segregation of Interacting Receptors

Tuesday, March 13 | 8:00AM - 11:00AM
Imaging Signaling in Cells and in vivo
Room: Grays Peak

Speaker 5 of 6
Eilon Sherman, NCI, National Institutes of Health, USA
Short Talk: Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

Tuesday, March 13 | 8:00AM - 11:00AM
Imaging Signaling in Cells and in vivo
Room: Grays Peak

Speaker 6 of 6
Sarah Russell, Swinburne University of Technology, Australia
How Important is Asymmetric Cell Division in the Control of Immune Cell Fate Decisions

Tuesday, March 13 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, March 13 | 11:00AM - 1:00PM
Poster Setup
Room: Longs/Quandary Peaks


Tuesday, March 13 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Tuesday, March 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs/Quandary Peaks


Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 1 of 9
* Eric S. Huseby, University of Massachusetts Medical School, USA

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 2 of 9
María Almena, National Center of Biotechnology, Spain
Diacylglycerol Metabolism Controls the Strength of Signaling during T Cell Development

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 3 of 9
Matthew L. Bettini, Baylor College of Medicine, USA
Basic Residues in the CD3epsilon Lipid Binding Region are Required for Normal TCR Signaling and T Cell Development

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 4 of 9
Mark R. Boothby, Vanderbilt University Medical Center, USA
Cell-Intrinsic Roles of mTOR Complex 2 in Development, Survival, and Functional Capacity of Mature B Cells and the Memory Response

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 5 of 9
Rebecca J. Brownlie, Edinburgh University, UK
Loss of the Cytoplasmic Phosphatase, PTPN22, Activates Regulatory T Cells that Control Effector T Cell Expansion

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 6 of 9
Nicole M. Chapman, St. Jude Children's Research Hospital, USA
Pyk2 Controls Distinct TCR-Induced Signaling Pathways Leading to PI3K Activation and T Cell Spreading in Human T Cells

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 7 of 9
Clifford S. Guy, St. Jude Children's Research Hospital, USA
Distinct T Cell Receptor Signaling Pathways Drive Proliferation and Cytokine Production in T Cells

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 8 of 9
John A. Hammer, NHLBI, National Institutes of Health, USA
Actin Retrograde Flow and Acto-Myosin II Arc Contraction Drive Receptor Cluster Dynamics at the Immunological Synapse in Jurkat T Cells

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 9 of 9
Jinsung Hong, Georgia Institute of Technology, USA
2D Kinetics of 3.L2 TCR-pMHC Binding Determine T Cell Function

Tuesday, March 13 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, March 13 | 5:00PM - 7:00PM
Ubiquitination and Proteolytic Control of Signaling
Room: Grays Peak

Speaker 1 of 5
* Sarah Russell, Swinburne University of Technology, Australia

Tuesday, March 13 | 5:00PM - 7:00PM
Ubiquitination and Proteolytic Control of Signaling
Room: Grays Peak

Speaker 2 of 5
Marc-Werner Dobenecker, Rockefeller University, USA

Tuesday, March 13 | 5:00PM - 7:00PM
Ubiquitination and Proteolytic Control of Signaling
Room: Grays Peak

Speaker 3 of 5
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Innate Immune Signaling

Tuesday, March 13 | 5:00PM - 7:00PM
Ubiquitination and Proteolytic Control of Signaling
Room: Grays Peak

Speaker 4 of 5
Leonard L. Dragone, National Jewish Health, USA
Short Talk: The Regulation of TCR Complex Signaling by Cullin-RING Ubiquitin Ligases

Tuesday, March 13 | 5:00PM - 7:00PM
Ubiquitination and Proteolytic Control of Signaling
Room: Grays Peak

Speaker 5 of 5
Averil I. Ma, University of California, San Francisco, USA
Ubiquitination and Innate Immune Signaling

Tuesday, March 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks


Tuesday, March 13 | 7:30PM - 10:00PM
Poster Session 2
Room: Longs/Quandary Peaks


Wednesday, March 14 | 7:00AM - 8:00AM
Breakfast
Room: Longs/Quandary Peaks


Wednesday, March 14 | 8:00AM - 11:15AM
Signaling to Control Developmental Transitions
Room: Grays Peak

Speaker 1 of 6
* Gary A. Koretzky, University of Pennsylvania School of Medicine, USA

Wednesday, March 14 | 8:00AM - 11:15AM
Signaling to Control Developmental Transitions
Room: Grays Peak

Speaker 2 of 6
Kristin A. Hogquist, University of Minnesota, USA
TCR Signal Strength in Thymic Selection

Wednesday, March 14 | 8:00AM - 11:15AM
Signaling to Control Developmental Transitions
Room: Grays Peak

Speaker 3 of 6
Benedict Seddon, University College London, UK
Short Talk: Regulation of Thymocyte Development and T Cell Homeostasis by Zap70 Signaling

Wednesday, March 14 | 8:00AM - 11:15AM
Signaling to Control Developmental Transitions
Room: Grays Peak

Speaker 4 of 6
Oreste Acuto, University of Oxford, UK
Themis: An Enigmatic Protein Required for Positive Selection

Wednesday, March 14 | 8:00AM - 11:15AM
Signaling to Control Developmental Transitions
Room: Grays Peak

Speaker 5 of 6
Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
Signals Controlling B Cell Development, Maintenance and Transformation

Wednesday, March 14 | 8:00AM - 11:15AM
Signaling to Control Developmental Transitions
Room: Grays Peak

Speaker 6 of 6
Tomohiro Kurosaki, Osaka University, Japan
Contribution of Transcription Factors to Rapid Responsiveness of IgG Type Memory B Cells

Wednesday, March 14 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, March 14 | 11:15AM - 1:00PM
Poster Setup
Room: Longs/Quandary Peaks


Wednesday, March 14 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, March 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs/Quandary Peaks


Wednesday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 1 of 9
* Ronald N. Germain, NIAID, National Institutes of Health, USA

Wednesday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 2 of 9
Li-Heng Hsu, University of Glasgow, UK
Analysing the Role of ERK MAPK Signaling in Tolerance and Priming of Antigen-Specific CD4+ T Cells in vitro

Wednesday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 3 of 9
Robert L. Kortum, National Cancer Institute, National Institutes of Health, USA
Signaling through the RasGEFs Sos1 and RasGRP1 is Required at Multiple Stages of Thymocyte Development

Wednesday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 4 of 9
Baoyu Liu, Georgia Institute of Technology, USA
Force-Regulated Interactions between T Cell and its Antigen

Wednesday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 5 of 9
Daniel Marshall, IP Group Plc, UK
The Role of TCR and Cytokine Signaling in the Development of Regulatory T-Cells

Wednesday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 6 of 9
Miguel E. Moreno-Garcia, Seattle Children's Research Institute, USA
Kinase-Independent Feedback Signaling of the TAK1/TAB1 Complex on BCL10 Turnover and NF-kappaB Activation in Lymphocytes

Wednesday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 7 of 9
Kole T. Roybal, University of California, San Francisco, USA
Systems-Scale Quantification of the Spatiotemporal Dynamics of Actin Regulation during T Cell Activation

Wednesday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 8 of 9
Wenqing Li, National Cancer Institute, USA
IL-7–Independent IL-7Ralpha Signaling in Childhood Acute Lymphoblastic Leukemia

Wednesday, March 14 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 9 of 9
Martin J. Richer, University of Iowa, USA
Inflammatory Cytokines Regulate Functional Avidity Maturation of CD8 T Cells by Enhancing T Cell Receptor Proximal Signaling

Wednesday, March 14 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, March 14 | 5:00PM - 7:00PM
Signaling in Tolerance and Selection
Room: Grays Peak

Speaker 1 of 5
* Kristin A. Hogquist, University of Minnesota, USA

Wednesday, March 14 | 5:00PM - 7:00PM
Signaling in Tolerance and Selection
Room: Grays Peak

Speaker 2 of 5
Nicholas R. J. Gascoigne, National University of Singapore and Scripps Research, Singapore
Short Talk: Themis Sets the Thymocyte Signaling Threshold between Positive and Negative/Agonist Selection

Wednesday, March 14 | 5:00PM - 7:00PM
Signaling in Tolerance and Selection
Room: Grays Peak

Speaker 3 of 5
Ed Palmer, University of Basel Hospital, Switzerland
Signaling Thresholds in Tolerance: Changing over Time

Wednesday, March 14 | 5:00PM - 7:00PM
Signaling in Tolerance and Selection
Room: Grays Peak

Speaker 4 of 5
Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
Signals Involved in Anergy

Wednesday, March 14 | 5:00PM - 7:00PM
Signaling in Tolerance and Selection
Room: Grays Peak

Speaker 5 of 5
John C. Cambier, University of Colorado, USA
B Cell Anergy: Molecular Underpinning, Translation to Human Disease and Exploitation for Therapy

Wednesday, March 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks


Wednesday, March 14 | 7:30PM - 10:00PM
Poster Session 3
Room: Longs/Quandary Peaks


Thursday, March 15 | 7:00AM - 8:00AM
Breakfast
Room: Longs/Quandary Peaks


Thursday, March 15 | 8:00AM - 11:15AM
Pathology Resulting from Signaling Aberrations
Room: Grays Peak

Speaker 1 of 7
* Averil I. Ma, University of California, San Francisco, USA

Thursday, March 15 | 8:00AM - 11:15AM
Pathology Resulting from Signaling Aberrations
Room: Grays Peak

Speaker 2 of 7
Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France
LAT Signaling Pathology: An 'Autoimmune' Condition without T Cell Self-Reactivity

Thursday, March 15 | 8:00AM - 11:15AM
Pathology Resulting from Signaling Aberrations
Room: Grays Peak

Speaker 3 of 7
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
Mechanisms of Cell Death Control Critical for a Functioning Immune System

Thursday, March 15 | 8:00AM - 11:15AM
Pathology Resulting from Signaling Aberrations
Room: Grays Peak

Speaker 4 of 7
Silvia Bolland, NIAID, National Institutes of Health, USA
TLR Signaling Abnormalities Leading to Autoimmunity

Thursday, March 15 | 8:00AM - 11:15AM
Pathology Resulting from Signaling Aberrations
Room: Grays Peak

Speaker 5 of 7
Michael Mingueneau, USA
Short Talk: Impact of NOD (Non-Obese Diabetic) Genetic Variation on Thymic Decision Checkpoints and TCR Signaling Networks

Thursday, March 15 | 8:00AM - 11:15AM
Pathology Resulting from Signaling Aberrations
Room: Grays Peak

Speaker 6 of 7
Louis M. Staudt, NCI, National Institutes of Health, USA
Therapeutic Strategies in Lymphoma Based on Oncogenic B Receptor and MYD88 Signaling

Thursday, March 15 | 8:00AM - 11:15AM
Pathology Resulting from Signaling Aberrations
Room: Grays Peak

Speaker 7 of 7
Jeroen Roose, University of California, San Francisco, USA
Short Talk: Effective Cooperation between Cytokine Receptor-Input and the Rasgrp1 Oncogene in T Cell Leukemogenesis

Thursday, March 15 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 15 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 1 of 9
* Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada

Thursday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 2 of 9
Karsten Sauer, Pfizer, USA
Feedback Regulation of TCR Signaling via PI3K by Soluble Inositol Tetrakisphosphate

Thursday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 3 of 9
Alexandra Schrader, University Medicine, Germany
New Pathway Activities in Aggressive Non-Hodgkin Lymphomas Identified via Guided Clustering

Thursday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 4 of 9
Rut Valdor, Albert Einstein College of Medicine, USA
Chaperone-Mediated Autophagy Regulates T Cell Function

Thursday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 5 of 9
Feng Wang, Stanford University School of Medicine, USA
T Cell Receptor and Membrane Dynamics Analyzed with Super-Resolution Imaging Secondary Ion Mass Spectrometry

Thursday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 6 of 9
Ruobing Wang, Seattle Biomedical Research Institute, USA
Fueling Immunity: Dissecting the Dynamic Interplay between Metabolic Pathways and Lymphocyte Signaling Cascades

Thursday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 7 of 9
Christoph Wülfing, University of Texas Southwestern Medical Center, USA
Itk Regulates the Spatiotemporal Organization of T Cell Signaling

Thursday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 8 of 9
Jun Zhong, Johns Hopkins University, USA
TSLP Signaling Revealed by Quantitative Phosphoproteomics

Thursday, March 15 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 9 of 9
Takashi Saito, RIKEN Center for Allergy and Immunology, Japan
Negative Regulation of TCR Signaling by PD-1 Microcluster

Thursday, March 15 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 15 | 5:00PM - 7:00PM
Therapeutic Targeting of Signaling Pathways
Room: Grays Peak

Speaker 1 of 4
* Louis M. Staudt, NCI, National Institutes of Health, USA

Thursday, March 15 | 5:00PM - 7:00PM
Therapeutic Targeting of Signaling Pathways
Room: Grays Peak

Speaker 2 of 4
John J. O'Shea, NIAMS, National Institutes of Health, USA
Jak Kinases as Targets

Thursday, March 15 | 5:00PM - 7:00PM
Therapeutic Targeting of Signaling Pathways
Room: Grays Peak

Speaker 3 of 4
Andrew C. Chan, Genentech, Inc., USA
Transforming Clinical Medicine into Molecular Medicine

Thursday, March 15 | 5:00PM - 7:00PM
Therapeutic Targeting of Signaling Pathways
Room: Grays Peak

Speaker 4 of 4
Stuart S. Winter, Children's Minnesota, USA
Short Talk: Macrophage and NK-Mediated Killing of Precursor-B Acute Lymphoblastic Leukemia Cell Lines and Primary Patient Samples Targeted with a-Fucosylated Anti-CD19 Humanized Antibodies

Thursday, March 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks


Thursday, March 15 | 8:00PM - 11:00PM
Entertainment
Room: Longs/Quandary Peaks


Thursday, March 15 | 8:00PM - 11:00PM
Cash Bar
Room: Longs/Quandary Peaks


Friday, March 16 | 10:25AM - 10:25AM
Departure


*Session Chair.