Web Desc
Complications of Diabetes: Mechanisms of Injury and Failure of Repair
Organizer(s): Rama Natarajan, Matthias Kretzler and E. Dale Abel
Date: March 11 - 16, 2012
Location: Boston Park Plaza, Boston, Massachusetts, USA
Sponsored by Merck & Co., Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
Diabetes is associated with significantly accelerated rates of several microvascular and macrovascular complications including nephropathy, neuropathy, retinopathy and atherosclerosis. Furthermore, results from both clinical trials and animal studies indicate that these complications might progress despite glycemic control, a phenomenon termed metabolic memory. Ongoing studies have identified biochemical and nuclear mechanisms, genetic determinants, epigenetic factors and non-coding RNAs in the pathogenesis of diabetic complications. Thus, the study of the key mechanisms leading to injury in target organs and failure of adaptive processes holds great promise for the identification of mechanism-targeted therapeutic approaches. These experimental approaches have been aided by tremendous advances in high-throughput genomic and epigenomic technologies, integrated systems biology and bioinformatics. Advances in the fields of stem cell therapies, induced pluripotency and regenerative medicine have provided new hope for the treatment of complications. The goal of this interdisciplinary meeting is to integrate these evolving concepts with current knowledge to facilitate a systems-level understanding of diabetic complications.
Scholarship Deadline: November 10 2011
Discounted Abstract Deadline: November 10 2011
Abstract Deadline: December 14 2011
Discounted Registration Deadline: January 12 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Merck & Co., Inc.
We gratefully acknowledge additional support for this conference from:
Aastrom Biosciences, Inc.Biogen IdecJDRF
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-03
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 11 | 3:00PM - 7:30PM
Registration
Room: Imperial Check Room


Sunday, March 11 | 6:15PM - 7:15PM
Refreshments
Room: Plaza Ballroom


Sunday, March 11 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Imperial Ballroom

Speaker 1 of 2
* Rama Natarajan, Beckman Research Institute of City of Hope, USA

Sunday, March 11 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Imperial Ballroom

Speaker 2 of 2
Kenneth R. Chien, Karolinska Institutet, Sweden
Driving Heart Progenitor Cell Fate and Regeneration in vivo via Chemically Modified mRNA

Monday, March 12 | 7:30AM - 8:30AM
Breakfast
Room: Plaza Ballroom


Monday, March 12 | 7:30AM - 8:30PM
Poster Setup
Room: Plaza Ballroom


Monday, March 12 | 8:30AM - 5:00PM
Poster Viewing
Room: Plaza Ballroom


Monday, March 12 | 8:30AM - 11:45AM
Mechanisms for Glucotoxicity and Lipotoxicity
Room: Imperial Ballroom

Speaker 1 of 6
Paul J. Thornalley, Warwick Medical School, UK
Glycation, Dicarbonyls and Oxidative Stress

Monday, March 12 | 8:30AM - 11:45AM
Mechanisms for Glucotoxicity and Lipotoxicity
Room: Imperial Ballroom

Speaker 2 of 6
George L. King, Joslin Diabetes Center, USA
Characterization of Protective Factors for Diabetic Retinopathy and Nephropathy

Monday, March 12 | 8:30AM - 11:45AM
Mechanisms for Glucotoxicity and Lipotoxicity
Room: Imperial Ballroom

Speaker 3 of 6
Karin E. Bornfeldt, University of Washington School of Medicine, USA
Monocyte/Macrophage Fatty Acid Metabolism is More Important than Glucose Metabolism in Mediating an Inflammatory Phenotype and Atherosclerosis

Monday, March 12 | 8:30AM - 11:45AM
Mechanisms for Glucotoxicity and Lipotoxicity
Room: Imperial Ballroom

Speaker 4 of 6
Ann Marie Schmidt, New York University Langone Medical Center, USA
RAGE, Signal Transduction and the Vascular Complications of Diabetes

Monday, March 12 | 8:30AM - 11:45AM
Mechanisms for Glucotoxicity and Lipotoxicity
Room: Imperial Ballroom

Speaker 5 of 6
Günaj Rakipovski, Novo Nordisk, Denmark
Short Talk: Fluctuating hyperglycemia induces higer levels of oxidative stress relative to sustained hyperglycemia in obese rats – possible role for lack of metabolic adaptation

Monday, March 12 | 8:30AM - 11:45AM
Mechanisms for Glucotoxicity and Lipotoxicity
Room: Imperial Ballroom

Speaker 6 of 6
Adam R. Wende, University of Alabama at Birmingham, USA
Short Talk: Glucose-Mediated Control of Mitochondrial Gene Expression and Oxidative Phosphorylation Protein Function in the Heart

Monday, March 12 | 9:40AM - 10:00AM
Coffee Break
Room: Imperial Foyer


Monday, March 12 | 10:00AM - 10:00AM
On Own for Dinner


Monday, March 12 | 11:45AM - 12:30PM
Lunch
Room: Plaza Ballroom


Monday, March 12 | 12:15PM - 2:30PM
Poster Session 1
Room: Plaza Ballroom


Monday, March 12 | 2:30PM - 4:30PM
Workshop 1: Techniques and Translational Approaches
Room: Imperial Ballroom

Speaker 1 of 5
* Simeon Taylor, University of Maryland School of Medicine, USA

Monday, March 12 | 2:30PM - 4:30PM
Workshop 1: Techniques and Translational Approaches
Room: Imperial Ballroom

Speaker 2 of 5
Thomas M. Coffman, NUS Duke Singapore, Singapore
Animal Models and Update on AMDCC

Monday, March 12 | 2:30PM - 4:30PM
Workshop 1: Techniques and Translational Approaches
Room: Imperial Ballroom

Speaker 3 of 5
Hans-Joachim Anders, University of Munich, Germany
Chemokine Related Targets in Diabetic Nephropathy

Monday, March 12 | 2:30PM - 4:30PM
Workshop 1: Techniques and Translational Approaches
Room: Imperial Ballroom

Speaker 4 of 5
Karin Agnes Maria Jandeleit-Dahm, Monash University, Australia
Drug Targets and Drugs for Diabetic Complications

Monday, March 12 | 2:30PM - 4:30PM
Workshop 1: Techniques and Translational Approaches
Room: Imperial Ballroom

Speaker 5 of 5
Matthew D. Breyer, Janssen Pharmaceutical Company, USA
Hurdles to the Development of Therapies for Diabetic Nephropathy: Making the Leap from Bench to Bedside

Monday, March 12 | 4:30PM - 5:00PM
Coffee Available
Room: Imperial Foyer


Monday, March 12 | 5:00PM - 7:00PM
Micro- and Macrovascular Damage Mechanisms
Room: Imperial Ballroom

Speaker 1 of 5
* George L. King, Joslin Diabetes Center, USA

Monday, March 12 | 5:00PM - 7:00PM
Micro- and Macrovascular Damage Mechanisms
Room: Imperial Ballroom

Speaker 2 of 5
Moshe Levi, Georgetown University, USA
Role of LXR in Diabetic Complications

Monday, March 12 | 5:00PM - 7:00PM
Micro- and Macrovascular Damage Mechanisms
Room: Imperial Ballroom

Speaker 3 of 5
Masaomi Nangaku, University of Tokyo School of Medicine, Japan
Abnormal Oxygen Metabolism and Epigenetic Changes in Diabetic Kidney Disease

Monday, March 12 | 5:00PM - 7:00PM
Micro- and Macrovascular Damage Mechanisms
Room: Imperial Ballroom

Speaker 4 of 5
Eva L. Feldman, University of Michigan, USA
Dyslipidemia in Diabetic Neuropathy

Monday, March 12 | 5:00PM - 7:00PM
Micro- and Macrovascular Damage Mechanisms
Room: Imperial Ballroom

Speaker 5 of 5
Nhat-Tu Le, University of Rochester, USA
Short Talk: A Crucial Role of p90RSK-Mediated Reduction of Endothelial ERK5 Transcriptional Activity in Endothelial Inflammation, Dysfunction, and Atherosclerosis Formation

Tuesday, March 13 | 7:30AM - 8:30AM
Breakfast
Room: Plaza Ballroom


Tuesday, March 13 | 7:30AM - 8:30AM
Poster Setup
Room: Plaza Ballroom


Tuesday, March 13 | 8:30AM - 5:00PM
Poster Viewing
Room: Plaza Ballroom


Tuesday, March 13 | 8:30AM - 11:45AM
Molecular Mechanisms of Injury and Novel Approaches to Cellu
lar Repair

Room: Imperial Ballroom

Speaker 1 of 7
* Eva L. Feldman, University of Michigan, USA

Tuesday, March 13 | 8:30AM - 11:45AM
Molecular Mechanisms of Injury and Novel Approaches to Cellu
lar Repair

Room: Imperial Ballroom

Speaker 2 of 7
Paola Romagnani, University of Florence, Italy
Renal Progenitors for Kidney Regeneration: A 'Renopoietic' System?

Tuesday, March 13 | 8:30AM - 11:45AM
Molecular Mechanisms of Injury and Novel Approaches to Cellu
lar Repair

Room: Imperial Ballroom

Speaker 3 of 7
Jan Kajstura, Brigham and Women's Hospital, Harvard Medical School, USA
Stem Cell and Diabetic Cardiomyopathy

Tuesday, March 13 | 8:30AM - 11:45AM
Molecular Mechanisms of Injury and Novel Approaches to Cellu
lar Repair

Room: Imperial Ballroom

Speaker 4 of 7
Maria B. Grant, University of Florida, USA
Activation of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis Enhances the Reparative Function of Dysfunctional Diabetic Endothelial Progenitors

Tuesday, March 13 | 8:30AM - 11:45AM
Molecular Mechanisms of Injury and Novel Approaches to Cellu
lar Repair

Room: Imperial Ballroom

Speaker 5 of 7
Sarah X. Zhang, University of Oklahoma Health Sciences Center, USA
ER Stress, Angiogenesis and Inflammation in Diabetic Retinopathy

Tuesday, March 13 | 8:30AM - 11:45AM
Molecular Mechanisms of Injury and Novel Approaches to Cellu
lar Repair

Room: Imperial Ballroom

Speaker 6 of 7
Josephine M. Forbes, Mater Medical Research Institute, Australia
Short Talk: Deletion of the Mitochondrial Flavoprotein Apoptosis Inducing Factor (AIF) Accelerates the Progression of Diabetic Nephropathy

Tuesday, March 13 | 8:30AM - 11:45AM
Molecular Mechanisms of Injury and Novel Approaches to Cellu
lar Repair

Room: Imperial Ballroom

Speaker 7 of 7
Zongwei Wang, Massachusetts General Hospital, USA
Short Talk: Inhibition of inflammatory mediators reverses the bladder dysfunction associated with Type 2 Diabetes

Tuesday, March 13 | 9:40AM - 10:00AM
Coffee Break
Room: Imperial Foyer


Tuesday, March 13 | 10:00AM - 10:00AM
On Own for Dinner


Tuesday, March 13 | 11:45AM - 12:30PM
Lunch
Room: Plaza Ballroom


Tuesday, March 13 | 12:15PM - 2:30PM
Poster Session 2
Room: Plaza Ballroom


Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 2: Extramural Funding Opportunities for Diabetes Co
mplications Research
Room: Imperial Ballroom

Speaker 1 of 6
* Ann Marie Schmidt, New York University Langone Medical Center, USA

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 2: Extramural Funding Opportunities for Diabetes Co
mplications Research
Room: Imperial Ballroom

Speaker 2 of 6
Tamara Darsow, American Diabetes Association, USA

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 2: Extramural Funding Opportunities for Diabetes Co
mplications Research
Room: Imperial Ballroom

Speaker 3 of 6
Helen D. Nickerson, Juvenile Diabetes Research Foundation, USA

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 2: Extramural Funding Opportunities for Diabetes Co
mplications Research
Room: Imperial Ballroom

Speaker 4 of 6
Teresa Jones, NIDDK, National Institutes of Health, USA

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 2: Extramural Funding Opportunities for Diabetes Co
mplications Research
Room: Imperial Ballroom

Speaker 5 of 6
Christian Ketchum, NIDDK, National Institutes of Health, USA
NIDDK Opportunities

Tuesday, March 13 | 2:30PM - 4:30PM
Workshop 2: Extramural Funding Opportunities for Diabetes Co
mplications Research
Room: Imperial Ballroom

Speaker 6 of 6
Tracy Rankin, NIDDK, National Institutes of Health, USA

Tuesday, March 13 | 4:30PM - 5:00PM
Coffee Available
Room: Imperial Foyer


Tuesday, March 13 | 5:00PM - 7:00PM
Oxidative Stress and Mitochondrial Dysfunction
Room: Imperial Ballroom

Speaker 1 of 5
* E. Dale Abel, University of Iowa, Carver College of Medicine, USA

Tuesday, March 13 | 5:00PM - 7:00PM
Oxidative Stress and Mitochondrial Dysfunction
Room: Imperial Ballroom

Speaker 2 of 5
Subramaniam Pennathur, University of Michigan, USA
Role of Lipoporotein Oxidation in Atherosclerosis

Tuesday, March 13 | 5:00PM - 7:00PM
Oxidative Stress and Mitochondrial Dysfunction
Room: Imperial Ballroom

Speaker 3 of 5
Irina G. Obrosova, Pennington Biomedical Research Center, Louisiana State University System, USA
Oxidative-Nitrosative Stress in Diabetic Neuropathy

Tuesday, March 13 | 5:00PM - 7:00PM
Oxidative Stress and Mitochondrial Dysfunction
Room: Imperial Ballroom

Speaker 4 of 5
Hanna E. Abboud, University of Texas, USA
Noxes, NADPH Oxidase and Diabetic Complications



Tuesday, March 13 | 5:00PM - 7:00PM
Oxidative Stress and Mitochondrial Dysfunction
Room: Imperial Ballroom

Speaker 5 of 5
Xianwen Yi, University of North Carolina, USA
Short Talk: Antioxidants, Mitochondria and Diabetic Nephropathy

Wednesday, March 14 | 7:30AM - 8:30AM
Breakfast
Room: Plaza Ballroom


Wednesday, March 14 | 7:30AM - 8:30AM
Poster Setup
Room: Plaza Ballroom


Wednesday, March 14 | 8:30AM - 5:00PM
Poster Viewing
Room: Plaza Ballroom


Wednesday, March 14 | 8:30AM - 11:45AM
Lessons Learned from Animal and Human Models of Diabetic Com
plications

Room: Imperial Ballroom

Speaker 1 of 7
* Katalin Susztak, University of Pennsylvania, USA

Wednesday, March 14 | 8:30AM - 11:45AM
Lessons Learned from Animal and Human Models of Diabetic Com
plications

Room: Imperial Ballroom

Speaker 2 of 7
Frank Chip Brosius III, University of Michigan, USA
How a Systems Approach Using Humans and Mice Can Bring New Insight to Understanding Diabetic Complications

Wednesday, March 14 | 8:30AM - 11:45AM
Lessons Learned from Animal and Human Models of Diabetic Com
plications

Room: Imperial Ballroom

Speaker 3 of 7
Susan Quaggin, Northwestern University, USA
VEGF Pathway and DN: Insight from Murine Models

Wednesday, March 14 | 8:30AM - 11:45AM
Lessons Learned from Animal and Human Models of Diabetic Com
plications

Room: Imperial Ballroom

Speaker 4 of 7
E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Novel Molecular Mechanisms for Diabetic Cardiomyopathy

Wednesday, March 14 | 8:30AM - 11:45AM
Lessons Learned from Animal and Human Models of Diabetic Com
plications

Room: Imperial Ballroom

Speaker 5 of 7
Mark Yore, Beth Israel Deaconess Medical Center & Harvard Medical School, USA
Vascular and Neural Dysfunction in Diabetic Models

Wednesday, March 14 | 8:30AM - 11:45AM
Lessons Learned from Animal and Human Models of Diabetic Com
plications

Room: Imperial Ballroom

Speaker 6 of 7
Charles E. Alpers, University of Washington, USA
Short Talk: The BTBR ob/ob Mouse is a Good Model of Diabetic Complications

Wednesday, March 14 | 8:30AM - 11:45AM
Lessons Learned from Animal and Human Models of Diabetic Com
plications

Room: Imperial Ballroom

Speaker 7 of 7
Richard C. Davis, University of California, Los Angeles, USA
Short Talk: Genetic Mapping of Genes Contributing to Diabetic Complications

Wednesday, March 14 | 9:40AM - 10:00AM
Coffee Break
Room: Imperial Foyer


Wednesday, March 14 | 10:00AM - 10:00AM
On Own for Dinner


Wednesday, March 14 | 11:45AM - 12:30PM
Lunch
Room: Plaza Ballroom


Wednesday, March 14 | 12:15PM - 2:30PM
Poster Session 3
Room: Plaza Ballroom


Wednesday, March 14 | 2:30PM - 3:00PM
Coffee Available
Room: Imperial Foyer


Wednesday, March 14 | 3:00PM - 5:00PM
Genetics
Room: Imperial Ballroom

Speaker 1 of 5
* Matthias Kretzler, University of Michigan, USA

Wednesday, March 14 | 3:00PM - 5:00PM
Genetics
Room: Imperial Ballroom

Speaker 2 of 5
Andrzej S. Krolewski, Joslin Diabetes Center, USA
Genetics of Nephropathy in Type 1 Diabetes: Search for Genes Contributing to Rapid Progression to End Stage Renal Disease (ESRD)

Wednesday, March 14 | 3:00PM - 5:00PM
Genetics
Room: Imperial Ballroom

Speaker 3 of 5
Barry I. Freedman, Wake Forest University Baptist Medical Center, USA
Genetic Factors in Diabetic and Non-Diabetic Nephropathy

Wednesday, March 14 | 3:00PM - 5:00PM
Genetics
Room: Imperial Ballroom

Speaker 4 of 5
Kang Zhang, University of California, San Diego, USA
Genetics of Diabetic Retinopathy

Wednesday, March 14 | 3:00PM - 5:00PM
Genetics
Room: Imperial Ballroom

Speaker 5 of 5
Eoin P. Brennan, Conway Institute, Ireland
Short Talk: New Genetic loci Associated with Kidney Disease in Type 1 Diabetes

Thursday, March 15 | 7:30AM - 8:30AM
Breakfast
Room: Plaza Ballroom


Thursday, March 15 | 8:30AM - 11:45AM
Role of Epigenetics and MicroRNAs in Diabetic End-Organ Dama
ge

Room: Imperial Ballroom

Speaker 1 of 7
* Hanna E. Abboud, University of Texas, USA

Thursday, March 15 | 8:30AM - 11:45AM
Role of Epigenetics and MicroRNAs in Diabetic End-Organ Dama
ge

Room: Imperial Ballroom

Speaker 2 of 7
Katalin Susztak, University of Pennsylvania, USA
Epigenetics in Human Diabetic Kidney Disease

Thursday, March 15 | 8:30AM - 11:45AM
Role of Epigenetics and MicroRNAs in Diabetic End-Organ Dama
ge

Room: Imperial Ballroom

Speaker 3 of 7
Rama Natarajan, Beckman Research Institute of City of Hope, USA
Role of Epigenetic Mechanisms and microRNAs Underlying Inflammation in Diabetic Vascular Complications and Metabolic Memory

Thursday, March 15 | 8:30AM - 11:45AM
Role of Epigenetics and MicroRNAs in Diabetic End-Organ Dama
ge

Room: Imperial Ballroom

Speaker 4 of 7
Farhad Danesh, University of Texas MD Anderson Cancer Center, USA
The Emerging Role of MicroRNAs in Diabetic Nephropathy

Thursday, March 15 | 8:30AM - 11:45AM
Role of Epigenetics and MicroRNAs in Diabetic End-Organ Dama
ge

Room: Imperial Ballroom

Speaker 5 of 7
Assam El-Osta, Monash University, Australia
Epigenetic Changes in Hyperglycemic Memory of Endothelial Dysfunction in Diabetes

Thursday, March 15 | 8:30AM - 11:45AM
Role of Epigenetics and MicroRNAs in Diabetic End-Organ Dama
ge

Room: Imperial Ballroom

Speaker 6 of 7
Mary R. Loeken, Joslin Diabetes Center, USA
Short Talk: Inhibition of Differentiation-Induced DNA Methylation Patterns Explains Disturbed Embryo Gene Expression during Diabetic Embryopathy

Thursday, March 15 | 8:30AM - 11:45AM
Role of Epigenetics and MicroRNAs in Diabetic End-Organ Dama
ge

Room: Imperial Ballroom

Speaker 7 of 7
Nancy E. Castro, City of Hope, USA
Short Talk: miR-30 and miR-130 Family Inhibition by Transforming Growth Factor beta1 Leads to Enhanced Pro-Fibrotic Genes in Mouse Kidney Mesangial Cells

Thursday, March 15 | 9:40AM - 10:00AM
Coffee Break
Room: Imperial Foyer


Thursday, March 15 | 11:45AM - 11:45AM
On Own for Lunch and Recreation


Thursday, March 15 | 4:30PM - 5:00PM
Coffee Available
Room: Imperial Foyer


Thursday, March 15 | 5:00PM - 7:00PM
Integrative Biology Approaches to Diabetic Complications
Room: Imperial Ballroom

Speaker 1 of 5
* Frank Chip Brosius III, University of Michigan, USA

Thursday, March 15 | 5:00PM - 7:00PM
Integrative Biology Approaches to Diabetic Complications
Room: Imperial Ballroom

Speaker 2 of 5
Aldons J. Lusis, University of California, Los Angeles, USA
Systems-Based Approaches to Cardiovascular and Metabolic Diseases

Thursday, March 15 | 5:00PM - 7:00PM
Integrative Biology Approaches to Diabetic Complications
Room: Imperial Ballroom

Speaker 3 of 5
Matthias Kretzler, University of Michigan, USA
Integration of Large-Scale Data Sets in Diabetic Nephropathy: Defining Networks of Repair, Progression and Response to Therapy

Thursday, March 15 | 5:00PM - 7:00PM
Integrative Biology Approaches to Diabetic Complications
Room: Imperial Ballroom

Speaker 4 of 5
Edward P. Feener, KalVista Pharmaceuticals, USA
Proteomic Networks in Diabetic Complications

Thursday, March 15 | 5:00PM - 7:00PM
Integrative Biology Approaches to Diabetic Complications
Room: Imperial Ballroom

Speaker 5 of 5
Wenjun Ju, University of Michigan, USA
Short Talk: A Novel Approach for Discovering Chronic Kidney Disease Associated Human Podocyte-Specific Genes

Thursday, March 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Plaza Ballroom


Thursday, March 15 | 8:00PM - 11:00PM
Entertainment
Room: Plaza Ballroom


Thursday, March 15 | 8:00PM - 11:00PM
Cash Bar
Room: Plaza Ballroom


Friday, March 16 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.