Mutations, Malignancy and Memory - Antibodies and Immunity

Organizer(s): F. Nina Papavasiliou and Sebastian D. Fugmann

Supported by an educational donation provided by Amgen

Summary of Meeting:

Mutations in the human genome are regarded as potentially disastrous events that lead to carcinogenesis. From the vantage point of B cell immunology, however, programmed DNA alterations at the antibody gene loci are essential for efficient antibody responses. A plethora of recent findings are beginning to illuminate open questions about the precise molecular mechanisms of these diversification processes, their regulation, and how errors in these pathways lead to cancer. Furthermore, the very same class of mutator enzymes plays an underappreciated role in non-lymphoid cancers, in antiviral responses and in epigenetic reprogramming. Antibody diversification not only shapes the repertoires of the immunological memory, but also those of auto-antibodies. The Keystone Symposia meeting on Mutations, Malignancy and Memory – Antibodies and Immunity will provide both a platform to integrate these more or less isolated fields and an opportunity to identify interfaces that could be relevant for therapeutic approaches in malignancies and autoimmune diseases.

Scholarship Deadline: November 15 2011

Discounted Abstract Deadline: November 15 2011

Abstract Deadline: December 15 2011

Discounted Registration Deadline: January 17 2012

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

Nabahet Ameur

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI098260-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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