Web Desc
Mutations, Malignancy and Memory - Antibodies and Immunity
Organizer(s): F. Nina Papavasiliou and Sebastian D. Fugmann
Date: March 18 - 22, 2012
Location: Boston Park Plaza, Boston, MA, USA
Supported by an educational donation provided by Amgen
Summary of Meeting:
Mutations in the human genome are regarded as potentially disastrous events that lead to carcinogenesis. From the vantage point of B cell immunology, however, programmed DNA alterations at the antibody gene loci are essential for efficient antibody responses. A plethora of recent findings are beginning to illuminate open questions about the precise molecular mechanisms of these diversification processes, their regulation, and how errors in these pathways lead to cancer. Furthermore, the very same class of mutator enzymes plays an underappreciated role in non-lymphoid cancers, in antiviral responses and in epigenetic reprogramming. Antibody diversification not only shapes the repertoires of the immunological memory, but also those of auto-antibodies. The Keystone Symposia meeting on Mutations, Malignancy and Memory – Antibodies and Immunity will provide both a platform to integrate these more or less isolated fields and an opportunity to identify interfaces that could be relevant for therapeutic approaches in malignancies and autoimmune diseases.
Scholarship Deadline: November 15 2011
Discounted Abstract Deadline: November 15 2011
Abstract Deadline: December 15 2011
Discounted Registration Deadline: January 17 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Educational donation provided by Amgen
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.


Nabahet Ameur
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI098260-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 18 | 3:00PM - 7:30PM
Registration
Room: Imperial Check Room


Sunday, March 18 | 6:15PM - 7:15PM
Refreshments
Room: Plaza Ballroom


Sunday, March 18 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Imperial Ballroom

Speaker 1 of 2
* F. Nina Papavasiliou, Deutsches Krebsforschungszentrum, Germany

Sunday, March 18 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Imperial Ballroom

Speaker 2 of 2
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
AID in Antibody Diversity and Lymphomas

Monday, March 19 | 7:30AM - 8:30AM
Breakfast
Room: Plaza Ballroom


Monday, March 19 | 7:30AM - 8:30AM
Poster Setup
Room: Plaza Ballroom


Monday, March 19 | 8:30AM - 5:00PM
Poster Viewing
Room: Plaza Ballroom


Monday, March 19 | 8:30AM - 11:45AM
Generation of Diversity
Room: Imperial Ballroom
This session focuses on the initiation of the antibody gene diversification event, V(D)J recombination, somatic hypermutation (SHM), class switch recombination (CSR), and immunoglobulin gene conversion(GCV), the key enzymes in these processes, AID and RAG1/2, and their regulation.
Speaker 1 of 8
* David G. Schatz, Yale University School of Medicine, USA

Monday, March 19 | 8:30AM - 11:45AM
Generation of Diversity
Room: Imperial Ballroom
This session focuses on the initiation of the antibody gene diversification event, V(D)J recombination, somatic hypermutation (SHM), class switch recombination (CSR), and immunoglobulin gene conversion(GCV), the key enzymes in these processes, AID and RAG1/2, and their regulation.
Speaker 2 of 8
Marjorie A. Oettinger, Massachusetts General Hospital, USA
V(D)J Recombination and Epigenetics

Monday, March 19 | 8:30AM - 11:45AM
Generation of Diversity
Room: Imperial Ballroom
This session focuses on the initiation of the antibody gene diversification event, V(D)J recombination, somatic hypermutation (SHM), class switch recombination (CSR), and immunoglobulin gene conversion(GCV), the key enzymes in these processes, AID and RAG1/2, and their regulation.
Speaker 3 of 8
Tasuku Honjo, Kyoto University Graduate School of Medicine, Japan
Short Talk: An Evolutionary View of the Mechanism for the Immune and Genome Diversity

Monday, March 19 | 8:30AM - 11:45AM
Generation of Diversity
Room: Imperial Ballroom
This session focuses on the initiation of the antibody gene diversification event, V(D)J recombination, somatic hypermutation (SHM), class switch recombination (CSR), and immunoglobulin gene conversion(GCV), the key enzymes in these processes, AID and RAG1/2, and their regulation.
Speaker 4 of 8
Javier M. Di Noia, Institut de Recherches Cliniques de Montreal, Canada
Regulation of AID

Monday, March 19 | 8:30AM - 11:45AM
Generation of Diversity
Room: Imperial Ballroom
This session focuses on the initiation of the antibody gene diversification event, V(D)J recombination, somatic hypermutation (SHM), class switch recombination (CSR), and immunoglobulin gene conversion(GCV), the key enzymes in these processes, AID and RAG1/2, and their regulation.
Speaker 5 of 8
Ali A. Zarrin, Genentech, Inc., USA
Modifications of Endogenous Switch Regions Provide Novel Insights into the Mechanisms of AID Targeting and Class Switch Recombination

Monday, March 19 | 8:30AM - 11:45AM
Generation of Diversity
Room: Imperial Ballroom
This session focuses on the initiation of the antibody gene diversification event, V(D)J recombination, somatic hypermutation (SHM), class switch recombination (CSR), and immunoglobulin gene conversion(GCV), the key enzymes in these processes, AID and RAG1/2, and their regulation.
Speaker 6 of 8
Sebastian D. Fugmann, Chang Gung University, Taiwan
Targeting AID-Dependent Diversification Processes to Antibody Genes

Monday, March 19 | 8:30AM - 11:45AM
Generation of Diversity
Room: Imperial Ballroom
This session focuses on the initiation of the antibody gene diversification event, V(D)J recombination, somatic hypermutation (SHM), class switch recombination (CSR), and immunoglobulin gene conversion(GCV), the key enzymes in these processes, AID and RAG1/2, and their regulation.
Speaker 7 of 8
Heinz Jacobs, Netherlands Cancer Institute, Netherlands
Short Talk: Targeting of AID: Distinguishing between Accessibility and Binding

Monday, March 19 | 8:30AM - 11:45AM
Generation of Diversity
Room: Imperial Ballroom
This session focuses on the initiation of the antibody gene diversification event, V(D)J recombination, somatic hypermutation (SHM), class switch recombination (CSR), and immunoglobulin gene conversion(GCV), the key enzymes in these processes, AID and RAG1/2, and their regulation.
Speaker 8 of 8
Patricia J. Gearhart, NIA, National Institutes of Health, USA
Short Talk: Transcriptional Stalling of RNA Polymerase II Gives AID Access to Immunoglobulin Variable Regions

Monday, March 19 | 9:40AM - 10:00AM
Coffee Break
Room: Imperial Foyer


Monday, March 19 | 10:00AM - 10:00AM
On Own for Dinner


Monday, March 19 | 11:45AM - 12:30PM
Lunch
Room: Plaza Ballroom


Monday, March 19 | 12:00PM - 2:30PM
Poster Session 1
Room: Plaza Ballroom


Monday, March 19 | 2:30PM - 4:30PM
Workshop 1: CSR/SHM/GCV Regulation and Targeting
Room: Imperial Ballroom

Speaker 1 of 9
* Claude-Agnès Reynaud, Necker-Paris Medical School, France

Monday, March 19 | 2:30PM - 4:30PM
Workshop 1: CSR/SHM/GCV Regulation and Targeting
Room: Imperial Ballroom

Speaker 2 of 9
Nobuo Sakaguchi, Kumamoto University, Japan
Role of GANP in Transcriptional Regulation of Immunoglobulin Gene Locus

Monday, March 19 | 2:30PM - 4:30PM
Workshop 1: CSR/SHM/GCV Regulation and Targeting
Room: Imperial Ballroom

Speaker 3 of 9
Amy L. Kenter, University of Illinois College of Medicine, USA
The Igh gamma1 Locus Organizes Long Range Chromatin Looping and Modulates CSR at Other CH Isotypes

Monday, March 19 | 2:30PM - 4:30PM
Workshop 1: CSR/SHM/GCV Regulation and Targeting
Room: Imperial Ballroom

Speaker 4 of 9
Michel C. Cogné, Centre National de la Recherche Scientifique, France
Immunoglobulin Heavy Chain Locus Suicide Recombination in Mature B Cells

Monday, March 19 | 2:30PM - 4:30PM
Workshop 1: CSR/SHM/GCV Regulation and Targeting
Room: Imperial Ballroom

Speaker 5 of 9
Mani Larijani, Memorial University of Newfoundland, Canada
Differences in the Enzymatic Efficiency of Human and Bony Fish AID are Mediated by a Single Residue in the C-Terminus Modulating Single-Stranded DNA Binding

Monday, March 19 | 2:30PM - 4:30PM
Workshop 1: CSR/SHM/GCV Regulation and Targeting
Room: Imperial Ballroom

Speaker 6 of 9
Prashant Kodgire, University of Chicago, USA
Nucleosome Stability Dramatically Impacts the Targeting of Somatic Hypermutations

Monday, March 19 | 2:30PM - 4:30PM
Workshop 1: CSR/SHM/GCV Regulation and Targeting
Room: Imperial Ballroom

Speaker 7 of 9
Jahan-Yar Parsa, University of Toronto, Canada
Negative Supercoiling Creates Single-Stranded Patches of DNA that are Substrates for AID-Mediated Mutagenesis

Monday, March 19 | 2:30PM - 4:30PM
Workshop 1: CSR/SHM/GCV Regulation and Targeting
Room: Imperial Ballroom

Speaker 8 of 9
Minghui He, Stockholm University, Sweden
Cell Cycle Regulation of Ig Class Switching

Monday, March 19 | 2:30PM - 4:30PM
Workshop 1: CSR/SHM/GCV Regulation and Targeting
Room: Imperial Ballroom

Speaker 9 of 9
Cesare Sala, Istituto Toscano Tumori, Italy
Activity of AID Driven by Cell Cycle Specific Promoters

Monday, March 19 | 4:30PM - 5:00PM
Coffee Available
Room: Imperial Foyer


Monday, March 19 | 5:00PM - 7:00PM
DNA Repair and Genomic Instability
Room: Imperial Ballroom
This session focuses on DNA repair in particular in the context of AID mediated sequence diversification reactions.
Speaker 1 of 5
* Anne Durandy, Institut Imagine, France

Monday, March 19 | 5:00PM - 7:00PM
DNA Repair and Genomic Instability
Room: Imperial Ballroom
This session focuses on DNA repair in particular in the context of AID mediated sequence diversification reactions.
Speaker 2 of 5
Janet M. Stavnezer, University of Massachusetts Medical School, USA
AID-Induced DNA Breaks and their Repair during Class Switching

Monday, March 19 | 5:00PM - 7:00PM
DNA Repair and Genomic Instability
Room: Imperial Ballroom
This session focuses on DNA repair in particular in the context of AID mediated sequence diversification reactions.
Speaker 3 of 5
Kevin D. Mills, The Jackson Laboratory, USA
Widespread Genomic Breaks Generated by AID Are Prevented by Homologous Recombination

Monday, March 19 | 5:00PM - 7:00PM
DNA Repair and Genomic Instability
Room: Imperial Ballroom
This session focuses on DNA repair in particular in the context of AID mediated sequence diversification reactions.
Speaker 4 of 5
Jayanta Chaudhuri, Memorial Sloan Kettering Cancer Center, USA
Regulation of Immunoglobulin Class Switch Recombination

Monday, March 19 | 5:00PM - 7:00PM
DNA Repair and Genomic Instability
Room: Imperial Ballroom
This session focuses on DNA repair in particular in the context of AID mediated sequence diversification reactions.
Speaker 5 of 5
Peter M. Bowers, AnaptysBio, Inc., USA
Short Talk: Human Activation-Induced Cytidine Deaminase (AID) Activity is Similar in vivo and in vitro as Analyzed by Next-Generation Sequencing

Tuesday, March 20 | 7:30AM - 8:30AM
Breakfast
Room: Plaza Ballroom


Tuesday, March 20 | 7:30AM - 8:30AM
Poster Setup
Room: Plaza Ballroom


Tuesday, March 20 | 8:30AM - 5:00PM
Poster Viewing
Room: Plaza Ballroom


Tuesday, March 20 | 8:30AM - 11:45AM
B Cell Lymphomas - Mutations, Translocations and Transcripti
on

Room: Imperial Ballroom
This session focuses on mechanisms of B lymphoma formation linked to antibody gene diversification processes.
Speaker 1 of 8
* Michael L. Atchison, University of Pennsylvania, School of Veterinary Medicine, USA

Tuesday, March 20 | 8:30AM - 11:45AM
B Cell Lymphomas - Mutations, Translocations and Transcripti
on

Room: Imperial Ballroom
This session focuses on mechanisms of B lymphoma formation linked to antibody gene diversification processes.
Speaker 2 of 8
Markus Müschen, Beckman Research Institute, USA
Infectious Origins of Childhood Leukemia

Tuesday, March 20 | 8:30AM - 11:45AM
B Cell Lymphomas - Mutations, Translocations and Transcripti
on

Room: Imperial Ballroom
This session focuses on mechanisms of B lymphoma formation linked to antibody gene diversification processes.
Speaker 3 of 8
Qiang Pan-Hammarström, Karolinska Institutet, Sweden
Pathway Targeted Deep-Sequencing of DNA-Repair Genes in Human B-Cell Lymphomas

Tuesday, March 20 | 8:30AM - 11:45AM
B Cell Lymphomas - Mutations, Translocations and Transcripti
on

Room: Imperial Ballroom
This session focuses on mechanisms of B lymphoma formation linked to antibody gene diversification processes.
Speaker 4 of 8
Frederick W. Alt, Boston Children's Hospital, USA
Mechanisms Contributing to Genomic Rearrangements in B Lineage Cells

Tuesday, March 20 | 8:30AM - 11:45AM
B Cell Lymphomas - Mutations, Translocations and Transcripti
on

Room: Imperial Ballroom
This session focuses on mechanisms of B lymphoma formation linked to antibody gene diversification processes.
Speaker 5 of 8
Alexander L. Kovalchuk, NIAID, National Institutes of Health, USA
Short Talk: A Mouse Model of Endemic Burkitt Translocations Reveals
the Long-Range Boundaries of Ig-Mediated Oncogene Deregulation


Tuesday, March 20 | 8:30AM - 11:45AM
B Cell Lymphomas - Mutations, Translocations and Transcripti
on

Room: Imperial Ballroom
This session focuses on mechanisms of B lymphoma formation linked to antibody gene diversification processes.
Speaker 6 of 8
Jane A. Skok, New York University School of Medicine, USA
Short Talk: Chromosomal Domains in Close Proximity to Igh in the Nucleus of Class Switching B Cells Are Predisposed to AID Mediated Translocations

Tuesday, March 20 | 8:30AM - 11:45AM
B Cell Lymphomas - Mutations, Translocations and Transcripti
on

Room: Imperial Ballroom
This session focuses on mechanisms of B lymphoma formation linked to antibody gene diversification processes.
Speaker 7 of 8
Sophia Shalhout, Wayne State University, USA
Short Talk: Uracils in Genomic DNA: A Useful Marker for Studying Lymphomogenesis

Tuesday, March 20 | 8:30AM - 11:45AM
B Cell Lymphomas - Mutations, Translocations and Transcripti
on

Room: Imperial Ballroom
This session focuses on mechanisms of B lymphoma formation linked to antibody gene diversification processes.
Speaker 8 of 8
Uttiya Basu, USA
Short Talk: Co-Transcriptional Regulation of the B Cell Mutator Activation Induced Cytidine Deaminase by the Non-Coding RNA Surveillance Complex RNA Exosome

Tuesday, March 20 | 9:40AM - 10:00AM
Coffee Break
Room: Imperial Foyer


Tuesday, March 20 | 10:00AM - 10:00AM
On Own for Dinner


Tuesday, March 20 | 11:45AM - 12:30PM
Lunch
Room: Plaza Ballroom


Tuesday, March 20 | 12:00PM - 2:30PM
Poster Session 2
Room: Plaza Ballroom


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 2: Molecular Mechanisms of CSR and SHM
Room: Imperial Ballroom

Speaker 1 of 9
* Michel C. Cogné, Centre National de la Recherche Scientifique, France

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 2: Molecular Mechanisms of CSR and SHM
Room: Imperial Ballroom

Speaker 2 of 9
Shyam Unniraman, Duke University, USA
Origin of Microhomologies during Class Switch Recombination

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 2: Molecular Mechanisms of CSR and SHM
Room: Imperial Ballroom

Speaker 3 of 9
Ramiro E. Verdun, University of Miami, USA
The Classical NHEJ and the Alternative End-Joining Pathways are not Competing for the Processing of DNA Breaks during Class-Switch Recombination

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 2: Molecular Mechanisms of CSR and SHM
Room: Imperial Ballroom

Speaker 4 of 9
Anne Durandy, Institut Imagine, France
Role of Mismatch Repair in Human Antibody Maturation

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 2: Molecular Mechanisms of CSR and SHM
Room: Imperial Ballroom

Speaker 5 of 9
Richard Chahwan, Albert Einstein College of Medicine, USA
Coordinating DNA Mismatches and Double-Strand Breaks at the Immunoglobulin Gene

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 2: Molecular Mechanisms of CSR and SHM
Room: Imperial Ballroom

Speaker 6 of 9
Huseyin Saribasak, Sifa University, Turkey
DNA Polymerase zeta Generates Tandem Mutations in Immunoglobulin Variable Regions

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 2: Molecular Mechanisms of CSR and SHM
Room: Imperial Ballroom

Speaker 7 of 9
Catarina S. Cortesão, Instituto Gulbenkian de Ciência, Portugal
AID Does Not Affect the Global Frequency of Meiotic Recombination in Mice

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 2: Molecular Mechanisms of CSR and SHM
Room: Imperial Ballroom

Speaker 8 of 9
Almudena R. Ramiro, Centro Nacional de Investigaciones Cardiovasculares, Spain
UNG Shapes the Specificity of AID-Induced Somatic Hypermutation

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 2: Molecular Mechanisms of CSR and SHM
Room: Imperial Ballroom

Speaker 9 of 9
Svend Petersen-Mahrt, IFOM-Fondazione Istituto FIRC di Oncologia Molecolare, Italy
Pre- and Post-Lesion AID Complexes

Tuesday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Imperial Foyer


Tuesday, March 20 | 5:00PM - 7:00PM
Mutator Enzymes in B Cells and Beyond
Room: Imperial Ballroom
This session focuses on non-classical roles of AID as a DNA demethylase as well as the biological function of other APOBEC deaminases (APOBEC2, APOBEC1, APOBEC3).
Speaker 1 of 6
* Silvestro Conticello, ISPRO, Italy

Tuesday, March 20 | 5:00PM - 7:00PM
Mutator Enzymes in B Cells and Beyond
Room: Imperial Ballroom
This session focuses on non-classical roles of AID as a DNA demethylase as well as the biological function of other APOBEC deaminases (APOBEC2, APOBEC1, APOBEC3).
Speaker 2 of 6
Cristina Rada, MRC Laboratory of Molecular Biology, UK
AID and Other APOBEC Proteins


Tuesday, March 20 | 5:00PM - 7:00PM
Mutator Enzymes in B Cells and Beyond
Room: Imperial Ballroom
This session focuses on non-classical roles of AID as a DNA demethylase as well as the biological function of other APOBEC deaminases (APOBEC2, APOBEC1, APOBEC3).
Speaker 3 of 6
Simon Wain-Hobson, Institut Pasteur, France
The Human APOBEC3 Cluster of Viral DNA Mutators, Part of a Much Bigger Picture

Tuesday, March 20 | 5:00PM - 7:00PM
Mutator Enzymes in B Cells and Beyond
Room: Imperial Ballroom
This session focuses on non-classical roles of AID as a DNA demethylase as well as the biological function of other APOBEC deaminases (APOBEC2, APOBEC1, APOBEC3).
Speaker 4 of 6
Sébastien Landry, The Salk Institute, USA
Short Talk: APOBEC3A Expression Activates the DNA Damage Response and Induces Cell Cycle Arrest

Tuesday, March 20 | 5:00PM - 7:00PM
Mutator Enzymes in B Cells and Beyond
Room: Imperial Ballroom
This session focuses on non-classical roles of AID as a DNA demethylase as well as the biological function of other APOBEC deaminases (APOBEC2, APOBEC1, APOBEC3).
Speaker 5 of 6
F. Nina Papavasiliou, Deutsches Krebsforschungszentrum, Germany
The RNA Editor APOBEC1 Can Reprogram Gene Expression

Tuesday, March 20 | 5:00PM - 7:00PM
Mutator Enzymes in B Cells and Beyond
Room: Imperial Ballroom
This session focuses on non-classical roles of AID as a DNA demethylase as well as the biological function of other APOBEC deaminases (APOBEC2, APOBEC1, APOBEC3).
Speaker 6 of 6
Duane R. Wesemann, Harvard Medical School, USA
Short Talk: Inhibiting DNA Methylation to Reprogram Activated, IgH Isotype Switched B Cells to Functional Grade Induced Pluripotent Stem Cells

Wednesday, March 21 | 7:30AM - 8:30AM
Breakfast
Room: Plaza Ballroom


Wednesday, March 21 | 8:30AM - 11:45AM
Autoimmunity and Antibody Diversity
Room: Imperial Ballroom
This session focuses on immunoglobulin diversification as a driver and/or guardian of autoimmune disease.
Speaker 1 of 6
* Eric Meffre, Yale University School of Medicine, USA
AID is Required for B Cell Tolerance in Humans

Wednesday, March 21 | 8:30AM - 11:45AM
Autoimmunity and Antibody Diversity
Room: Imperial Ballroom
This session focuses on immunoglobulin diversification as a driver and/or guardian of autoimmune disease.
Speaker 2 of 6
Qing C. Chen, University of Maryland School of Medicine, USA
Low-Affinity Natural Autoantibodies Protect from Autoimmune Disease

Wednesday, March 21 | 8:30AM - 11:45AM
Autoimmunity and Antibody Diversity
Room: Imperial Ballroom
This session focuses on immunoglobulin diversification as a driver and/or guardian of autoimmune disease.
Speaker 3 of 6
Marilyn Diaz, NIEHS, National Institutes of Health, USA
The Role of AID in B-Cell Mediated Autoimmune Disease

Wednesday, March 21 | 8:30AM - 11:45AM
Autoimmunity and Antibody Diversity
Room: Imperial Ballroom
This session focuses on immunoglobulin diversification as a driver and/or guardian of autoimmune disease.
Speaker 4 of 6
Lawrence J. Wysocki, National Jewish Health, USA
AID Generates Anti-Nuclear Antibodies in Systemic Autoimmunity

Wednesday, March 21 | 8:30AM - 11:45AM
Autoimmunity and Antibody Diversity
Room: Imperial Ballroom
This session focuses on immunoglobulin diversification as a driver and/or guardian of autoimmune disease.
Speaker 5 of 6
Elisa Corsiero, Barts and the London School of Medicine, UK
Short Talk: Analysis of Recombinant Monoclonal Antibodies from Single B Cells Reveals Early Defects of B Cell Tolerance Checkpoints in Patients with Sjögren’s Syndrome

Wednesday, March 21 | 8:30AM - 11:45AM
Autoimmunity and Antibody Diversity
Room: Imperial Ballroom
This session focuses on immunoglobulin diversification as a driver and/or guardian of autoimmune disease.
Speaker 6 of 6
Benjamin Umiker, Merck, Co., Inc, USA
Short Talk: Aicda Expression in Immature B Cells as a Potential Mechanism for Tolerance and Autoantibody Production in a Model of Systemic Lupus Erythematosus (SLE)

Wednesday, March 21 | 9:40AM - 10:00AM
Coffee Break
Room: Imperial Foyer


Wednesday, March 21 | 11:45AM - 11:45AM
On Own for Lunch and Recreation


Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 3: Deaminases and Tumorigenesis
Room: Imperial Ballroom

Speaker 1 of 9
* Kevin M. McBride, University of Texas MD Anderson Cancer Center, USA

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 3: Deaminases and Tumorigenesis
Room: Imperial Ballroom

Speaker 2 of 9
Rahul M. Kohli, University of Pennsylvania, USA
AID/APOBEC Deaminases Discriminate against 5-Substituted Cytosines: Implications for DNA Demethylation

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 3: Deaminases and Tumorigenesis
Room: Imperial Ballroom

Speaker 3 of 9
Silvestro Conticello, ISPRO, Italy
APOBEC1 and Mutagenesis

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 3: Deaminases and Tumorigenesis
Room: Imperial Ballroom

Speaker 4 of 9
Denise P. Muñoz, Children's Hospital Oakland Research Institute, USA
Activation-Induced Cytidine Deaminase (AID) is Necessary for the Epithelial-Mesenchymal Transition (EMT) in a Breast Cancer Model

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 3: Deaminases and Tumorigenesis
Room: Imperial Ballroom

Speaker 5 of 9
Saravanan Yuvaraj, Erasmus Medical Centrum, Netherlands
The Role of Antigenic Stimulation in the Pathogenesis of Chronic Lymphocytic Leukemia

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 3: Deaminases and Tumorigenesis
Room: Imperial Ballroom

Speaker 6 of 9
Andrea Paun, National Institutes of Health, USA
Exploring the Contribution of NF-kappa B to the Establishment of B Cell Malignancies

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 3: Deaminases and Tumorigenesis
Room: Imperial Ballroom

Speaker 7 of 9
Frederic B. Davi, Hôpital de la Pitié Salpêtrière Paris, France
Primary Intraocular Lymphomas Display a Remarkably Biased Immunoglobulin Heavy Chain Gene Repertoire and Precisely Targeted Somatic Hypermutation Suggesting Antigenic Selection of the Neoplastic Cells

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 3: Deaminases and Tumorigenesis
Room: Imperial Ballroom

Speaker 8 of 9
Lesley Ann Sutton, Karolinska Institutet, Sweden
Transcriptome Sequencing Reveals Novel Mutations and Differential Gene Expression in Stereotyped Subsets of Chronic Lymphocytic Leukemia

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 3: Deaminases and Tumorigenesis
Room: Imperial Ballroom

Speaker 9 of 9
Parameswary A. Muniandy, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Integrated Analysis of Tumor Transcriptome and miRNOME of B Cell Lymphoma Reveal Interplay of Multiple Cancer Signaling Pathways

Wednesday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Imperial Foyer


Wednesday, March 21 | 5:00PM - 7:00PM
Generation of B Cell Memory
Room: Imperial Ballroom
This session focuses on the studies on the generation and maintenance of B cell memory and their antibody repertoire.
Speaker 1 of 5
* Sebastian D. Fugmann, Chang Gung University, Taiwan

Wednesday, March 21 | 5:00PM - 7:00PM
Generation of B Cell Memory
Room: Imperial Ballroom
This session focuses on the studies on the generation and maintenance of B cell memory and their antibody repertoire.
Speaker 2 of 5
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Antibody Repertoire in Memory B Cells

Wednesday, March 21 | 5:00PM - 7:00PM
Generation of B Cell Memory
Room: Imperial Ballroom
This session focuses on the studies on the generation and maintenance of B cell memory and their antibody repertoire.
Speaker 3 of 5
Patrick C. Wilson, University of Chicago, USA
Human B Cell Responses to Influenza; Lessons from Unique Populations

Wednesday, March 21 | 5:00PM - 7:00PM
Generation of B Cell Memory
Room: Imperial Ballroom
This session focuses on the studies on the generation and maintenance of B cell memory and their antibody repertoire.
Speaker 4 of 5
Mary M. Tomayko, Yale University School of Medicine, USA
Molecular Basis of B Cell Memory Generation and Maintenance

Wednesday, March 21 | 5:00PM - 7:00PM
Generation of B Cell Memory
Room: Imperial Ballroom
This session focuses on the studies on the generation and maintenance of B cell memory and their antibody repertoire.
Speaker 5 of 5
Alaitz Aranburu, Research Centre, Ospedale Bambino Gesu, Italy
Short Talk: The Defined Molecular Features of Adult IgM Memory B Cells Are “Imprinted” in the First Year of Life

Wednesday, March 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Plaza Ballroom


Wednesday, March 21 | 8:00PM - 11:00PM
Entertainment
Room: Plaza Ballroom


Wednesday, March 21 | 8:00PM - 11:00PM
Cash Bar
Room: Plaza Ballroom


Thursday, March 22 | 10:25AM - 10:25AM
Departure


*Session Chair.