Web Desc
Molecular Basis of Vascular Inflammation and Atherosclerosis
Organizer(s): Edward A. Fisher, Catherine C. Hedrick and MacRae F. Linton
Date: March 25 - 30, 2012
Location: Big Sky Resort, Big Sky, MT, USA
Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc. and Merck & Co., Inc.
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Summary of Meeting:
Inflammation is inextricably woven into the natural history of atherosclerosis. The macrophage is integral to the pathogenesis of atherosclerosis, functioning at the intersection of inflammation and cholesterol homeostasis, making its biological properties an important topic. Consequently, macrophage biology will be a major focus of the Keystone Symposia meeting on Molecular Basis of Vascular Inflammation and Atherosclerosis. The critical contributions of innate and adaptive immunities to atherosclerosis will also be reviewed, and a session on fundamental features of the inflammatory process, including its resolution, will introduce concepts likely to influence future paradigms in the atherosclerosis field. Recently discovered factors that regulate levels of atherogenic lipoproteins, key initiators of arterial inflammation, will be presented. Other highlights include progress in genomic approaches to discover risk factors for coronary artery disease, as well as advances in imaging techniques to detect atherosclerotic plaques, cellular composition of plaques and trafficking of immune cells in vivo. The keynote address will highlight emerging roles of nuclear hormone receptors as integrators of plaque lipid metabolism and immune activity.
Scholarship Deadline: November 22 2011
Discounted Abstract Deadline: November 22 2011
Abstract Deadline: January 3 2012
Discounted Registration Deadline: January 25 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Boehringer Ingelheim Pharmaceuticals, Inc.Merck & Co., Inc.
We gratefully acknowledge additional support for this conference from:
Aastrom Biosciences, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Regeneron Pharmaceuticals, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL112449-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 25 | 3:00PM - 7:30PM
Registration
Room: Lower Atrium


Sunday, March 25 | 6:15PM - 7:15PM
Refreshments
Room: Lower Atrium


Sunday, March 25 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Jefferson

Speaker 1 of 2
* Edward A. Fisher, New York University School of Medicine, USA

Sunday, March 25 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Jefferson

Speaker 2 of 2
Peter Tontonoz, University of California, Los Angeles, USA
Nuclear Receptor Regulation of Lipid Metabolism and Inflammation

Monday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Madison/Gallatin


Monday, March 26 | 8:00AM - 11:00AM
Macrophage Biology
Room: Jefferson

Speaker 1 of 6
* Catherine Hedrick, La Jolla Institute for Immunology, USA

Monday, March 26 | 8:00AM - 11:00AM
Macrophage Biology
Room: Jefferson

Speaker 2 of 6
Kathryn J. Moore, New York University Medical Center, USA
Role of Retention Molecules in Macrophage Accumulation in Atherosclerosis

Monday, March 26 | 8:00AM - 11:00AM
Macrophage Biology
Room: Jefferson

Speaker 3 of 6
Klaus Ley, La Jolla Institute for Allergy and Immunology, USA
Multiphoton Live Cell Imaging Reveals Productive Antigen-Specific Interactions between CD4 T Cells and Dendritic Cells in the Aortic Wall of Apoe-/- Mice

Monday, March 26 | 8:00AM - 11:00AM
Macrophage Biology
Room: Jefferson

Speaker 4 of 6
Edward A. Fisher, New York University School of Medicine, USA
Macrophage Diversity in Mouse Atherosclerotic Plaques

Monday, March 26 | 8:00AM - 11:00AM
Macrophage Biology
Room: Jefferson

Speaker 5 of 6
MacRae F. Linton, Vanderbilt University Medical Center, USA
Macrophage JNK Signaling in Apoptosis and Atherosclerosis

Monday, March 26 | 8:00AM - 11:00AM
Macrophage Biology
Room: Jefferson

Speaker 6 of 6
Richard N. Hanna, MedImmune, USA
Short Talk: NR4A1 (Nur77) Deficiency Increases Inflammatory Macrophage Activity and Atherosclerosis Development

Monday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Monday, March 26 | 11:00AM - 1:00PM
Poster Setup
Room: Madison/Gallatin


Monday, March 26 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Monday, March 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Madison/Gallatin


Monday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Monday, March 26 | 5:00PM - 7:00PM
Adaptive Immunity in Atherosclerosis
Room: Jefferson

Speaker 1 of 5
* Elena Galkina, Eastern Virginia Medical School, USA

Monday, March 26 | 5:00PM - 7:00PM
Adaptive Immunity in Atherosclerosis
Room: Jefferson

Speaker 2 of 5
Amy S. Major, Vanderbilt University, USA
T Lymphocytes Are Important Mediators of Autoimmune-Associated Atherosclerosis

Monday, March 26 | 5:00PM - 7:00PM
Adaptive Immunity in Atherosclerosis
Room: Jefferson

Speaker 3 of 5
Andrew H. Lichtman, Brigham and Women's Hospital, USA
Regulation of T Cell Responses in Atherosclerosis

Monday, March 26 | 5:00PM - 7:00PM
Adaptive Immunity in Atherosclerosis
Room: Jefferson

Speaker 4 of 5
Mary G. Sorci-Thomas, Wake Forest School of Medicine, USA
HDL-Mediated Regulation of Lymphocyte Function

Monday, March 26 | 5:00PM - 7:00PM
Adaptive Immunity in Atherosclerosis
Room: Jefferson

Speaker 5 of 5
Claudia Monaco, University of Oxford, UK
Short Talk: B Regulatory Cells Mediate Atheroprotection via IL-10

Monday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Madison/Gallatin


Monday, March 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Madison/Gallatin


Tuesday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Madison/Gallatin


Tuesday, March 27 | 8:00AM - 11:15AM
Innate Immunity in Atherosclerosis
Room: Jefferson

Speaker 1 of 7
* MacRae F. Linton, Vanderbilt University Medical Center, USA

Tuesday, March 27 | 8:00AM - 11:15AM
Innate Immunity in Atherosclerosis
Room: Jefferson

Speaker 2 of 7
Ira Tabas, Columbia University, USA
The Role of MyD88 Signaling in CD11chi Cells in Atherosclerosis

Tuesday, March 27 | 8:00AM - 11:15AM
Innate Immunity in Atherosclerosis
Room: Jefferson

Speaker 3 of 7
Myron I. Cybulsky, University of Toronto, Canada
Role of Intimal Dendritic Cells in the Initiation of Atherosclerosis

Tuesday, March 27 | 8:00AM - 11:15AM
Innate Immunity in Atherosclerosis
Room: Jefferson

Speaker 4 of 7
Peter S. Tobias, The Scripps Research Institute, USA
Toll-Like Receptors in Atherosclerosis

Tuesday, March 27 | 8:00AM - 11:15AM
Innate Immunity in Atherosclerosis
Room: Jefferson

Speaker 5 of 7
Catherine Hedrick, La Jolla Institute for Immunology, USA
Role of Cholesterol in Modulating Innate Immune Responses

Tuesday, March 27 | 8:00AM - 11:15AM
Innate Immunity in Atherosclerosis
Room: Jefferson

Speaker 6 of 7
Yvonne Döring, Institute for Cardiovascular Prevention Ludwig-Maximilians University Munich, Germany
Short Talk: CCL17-Expressing Dendritic Cells Drive Atherosclerosis by Restraining Regulatory T Cell Homeostasis in Mice

Tuesday, March 27 | 8:00AM - 11:15AM
Innate Immunity in Atherosclerosis
Room: Jefferson

Speaker 7 of 7
Ebru Erbay, Bilkent University, Turkey
Short Talk: Macrophage Lipid Chaperones Link Host, Pathogen and Metabolism

Tuesday, March 27 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Tuesday, March 27 | 11:15AM - 1:00PM
Poster Setup
Room: Madison/Gallatin


Tuesday, March 27 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Madison/Gallatin


Tuesday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Tuesday, March 27 | 5:00PM - 7:00PM
Inflammation Biology Relevant to Atherosclerosis
Room: Jefferson

Speaker 1 of 5
* Kathryn J. Moore, New York University Medical Center, USA

Tuesday, March 27 | 5:00PM - 7:00PM
Inflammation Biology Relevant to Atherosclerosis
Room: Jefferson

Speaker 2 of 5
Ann Marie Schmidt, New York University Langone Medical Center, USA
RAGE, Formins and New Insights into RAGE Signal Transduction

Tuesday, March 27 | 5:00PM - 7:00PM
Inflammation Biology Relevant to Atherosclerosis
Room: Jefferson

Speaker 3 of 5
Kenneth L. Rock, University of Massachusetts Medical School, USA
The Sterile Inflammatory Response and Atherosclerosis

Tuesday, March 27 | 5:00PM - 7:00PM
Inflammation Biology Relevant to Atherosclerosis
Room: Jefferson

Speaker 4 of 5
Charles N. Serhan, Brigham and Women's Hospital, USA
Functional Decoding Lipid Mediator-Metabolomics in Resolving Inflammation


Tuesday, March 27 | 5:00PM - 7:00PM
Inflammation Biology Relevant to Atherosclerosis
Room: Jefferson

Speaker 5 of 5
Prabhakara Redd Nagareddy, Columbia University, USA
Short Talk: Hyperglycemia Enhances Myeloid Cell Proliferation and Impairs Atherosclerosis Regression in Diabetes

Tuesday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Madison/Gallatin


Tuesday, March 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Madison/Gallatin


Wednesday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: Madison/Gallatin


Wednesday, March 28 | 8:00AM - 11:15AM
Genetics of Atherosclerosis
Room: Jefferson

Speaker 1 of 7
* Klaus Ley, La Jolla Institute for Allergy and Immunology, USA

Wednesday, March 28 | 8:00AM - 11:15AM
Genetics of Atherosclerosis
Room: Jefferson

Speaker 2 of 7
Robert Hegele, Robarts Research Institute, Canada
Genetic Architecture of Plasma Triglyceride Metabolism

Wednesday, March 28 | 8:00AM - 11:15AM
Genetics of Atherosclerosis
Room: Jefferson

Speaker 3 of 7
Norman E. Sharpless, NCI, National Institutes of Health, USA
The 9p21.3 CDKN2a/b Locus and the Risk of Atherosclerosis

Wednesday, March 28 | 8:00AM - 11:15AM
Genetics of Atherosclerosis
Room: Jefferson

Speaker 4 of 7
Muredach P. Reilly, Columbia University, USA
Translational Studies of ADAMTS7 a Novel GWAS Locus for Coronary Atherosclerosis

Wednesday, March 28 | 8:00AM - 11:15AM
Genetics of Atherosclerosis
Room: Jefferson

Speaker 5 of 7
Kiran Musunuru, University of Pennsylvania, USA
Genetic and Functional Studies of SORT1, a Cholesterol and Myocardial Infarction Gene

Wednesday, March 28 | 8:00AM - 11:15AM
Genetics of Atherosclerosis
Room: Jefferson

Speaker 6 of 7
Jonathan E. Feig, New York University School of Medicine, USA
Short Talk: Regression of Atherosclerosis is Characterized by Broad Changes in the Plaque Macrophage Transcriptome

Wednesday, March 28 | 8:00AM - 11:15AM
Genetics of Atherosclerosis
Room: Jefferson

Speaker 7 of 7
Naif A. M. Almontashiri, University of Ottawa Heart Institute, Canada
Short Talk: Serum Interferon alpha-21 is a Biomarker that Predicts Coronary Artery Disease in Individuals Homozygous for the 9p21.3 Risk Locus

Wednesday, March 28 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Wednesday, March 28 | 11:15AM - 1:00PM
Poster Setup
Room: Madison/Gallatin


Wednesday, March 28 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Madison/Gallatin


Wednesday, March 28 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Wednesday, March 28 | 5:00PM - 7:00PM
Non-Immune Cells in Atherosclerosis
Room: Jefferson

Speaker 1 of 5
* Ann Marie Schmidt, New York University Langone Medical Center, USA

Wednesday, March 28 | 5:00PM - 7:00PM
Non-Immune Cells in Atherosclerosis
Room: Jefferson

Speaker 2 of 5
Wayne Orr, Lousiana State University Health Sciences Center, Shreveport, USA
EphA2 Activation Promotes the Endothelial Cell Inflammatory Response: A Potential Role in Atherosclerosis

Wednesday, March 28 | 5:00PM - 7:00PM
Non-Immune Cells in Atherosclerosis
Room: Jefferson

Speaker 3 of 5
Nigel Mackman, University of North Carolina at Chapel Hill, USA
Tissue Factor and Atherothrombosis

Wednesday, March 28 | 5:00PM - 7:00PM
Non-Immune Cells in Atherosclerosis
Room: Jefferson

Speaker 4 of 5
Joseph M. Miano, University of Rochester, USA
Genomic Regulation of Vascular Smooth Muscle Cell Phenotype

Wednesday, March 28 | 5:00PM - 7:00PM
Non-Immune Cells in Atherosclerosis
Room: Jefferson

Speaker 5 of 5
Richard C. Austin, McMaster University, Canada
Short Talk: Deficiency of TDAG51 Reduces Atherosclerotic Lesion Growth and Necrosis by Modulating Apoptosis, Cholesterol Efflux and Peroxiredoxin-1 Expression

Wednesday, March 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Madison/Gallatin


Wednesday, March 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Madison/Gallatin


Thursday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: Madison/Gallatin


Thursday, March 29 | 8:00AM - 11:00AM
Lipoprotein Metabolism and Atherosclerosis
Room: Jefferson

Speaker 1 of 6
* Mary G. Sorci-Thomas, Wake Forest School of Medicine, USA

Thursday, March 29 | 8:00AM - 11:00AM
Lipoprotein Metabolism and Atherosclerosis
Room: Jefferson

Speaker 2 of 6
Sergio Fazio, Vanderbilt University Medical Center, USA
A Novel Domain Interaction Regulates PCSK9 Secretion and Function

Thursday, March 29 | 8:00AM - 11:00AM
Lipoprotein Metabolism and Atherosclerosis
Room: Jefferson

Speaker 3 of 6
Viktoria Gusarova, Regeneron Pharmaceuticals, USA
Fully Human Antibody That Blocks PCSK9 Demonstrates Reduction in LDL-C Preclinically and in Early Clinical Trials

Thursday, March 29 | 8:00AM - 11:00AM
Lipoprotein Metabolism and Atherosclerosis
Room: Jefferson

Speaker 4 of 6
Carlos Fernández-Hernando, New York University School of Medicine, USA
Role of miRNAs in Regulating Macrophage and Hepatic Lipid Metabolism

Thursday, March 29 | 8:00AM - 11:00AM
Lipoprotein Metabolism and Atherosclerosis
Room: Jefferson

Speaker 5 of 6
Theo J. C. Van Berkel, University of Leiden, Netherlands
Lipoproteins, Macrophage Cholesterol Homeostasis and Atherosclerosis

Thursday, March 29 | 8:00AM - 11:00AM
Lipoprotein Metabolism and Atherosclerosis
Room: Jefferson

Speaker 6 of 6
Bernd Hewing, New York University School of Medicine, USA
Short Talk: Impact of Myeloperoxidase-modified ApoA-I on Regression of Atherosclerosis

Thursday, March 29 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Thursday, March 29 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, March 29 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Thursday, March 29 | 5:00PM - 7:00PM
Molecular Imaging
Room: Jefferson

Speaker 1 of 5
* Edward A. Fisher, New York University School of Medicine, USA

Thursday, March 29 | 5:00PM - 7:00PM
Molecular Imaging
Room: Jefferson

Speaker 2 of 5
Zahi A. Fayad, Mount Sinai Medical School, USA
Translational Bleeding Edge Imaging and Therapy of Atherosclersosis

Thursday, March 29 | 5:00PM - 7:00PM
Molecular Imaging
Room: Jefferson

Speaker 3 of 5
Matthias Nahrendorf, Massachusetts General Hospital, USA
In vivo Imaging of Plaque Composition

Thursday, March 29 | 5:00PM - 7:00PM
Molecular Imaging
Room: Jefferson

Speaker 4 of 5
Eric Ahrens, Carnegie Mellon University, USA
In vivo Cytometry: An MRI-Based Approach to Quantitatively Study Inflammation and Cell Trafficking


Thursday, March 29 | 5:00PM - 7:00PM
Molecular Imaging
Room: Jefferson

Speaker 5 of 5
Bohumil Bednar, Merck Research Laboratories, USA
Short Talk: Quantitative Longitudinal Imaging of Vascular Inflammation and Angiogenesis in Atherosclerotic Mice Using Newly Developed Optical Imaging Biomarkers of Cathepsin Activity and alphavbeta3 Integrin

Thursday, March 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Madison/Gallatin


Thursday, March 29 | 8:00PM - 11:00PM
Entertainment
Room: Madison/Gallatin


Thursday, March 29 | 8:00PM - 11:00PM
Cash Bar
Room: Madison/Gallatin


Friday, March 30 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.