Nuclear Receptor Matrix: Reloaded

Organizer(s): Ronald M. Evans and David J. Mangelsdorf

Supported by the Directors' Fund

Summary of Meeting:

Nuclear receptors (NRs) represent a large superfamily of transcription factors that function as ligand-dependent sensors for a diverse set of fat-soluble hormones, vitamins and dietary lipids. Together, NRs govern expression of genes involved in a broad range of reproductive, developmental, metabolic and immune response programs. For this reason, NRs have been investigated for over 20 years as promising targets for drugs to treat a multitude of therapeutic indices, including cancer, diabetes, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. However, despite the success of numerous NR-based therapies, there remain significant hurdles exploiting NRs to develop newer classes of therapies that achieve targeted benefits with reduced side effects. Thus, understanding the mechanisms, transcriptional targets and networks of physiologic pathways that govern NR action has become an important new strategy for evaluating the role of NRs in health and disease. This “reloaded” effort is now beginning to produce exciting new avenues of research in the field. This meeting will bring together a key group of junior and senior investigators that are exploring these new directions and provide participants with a matrix of unique possibilities for them to investigate in both academic and pharmaceutical laboratory settings.

Scholarship Deadline: December 15 2011

Discounted Abstract Deadline: December 15 2011

Abstract Deadline: January 18 2012

Discounted Registration Deadline: February 15 2012

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Aragon Pharmaceuticals, Inc.

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-03
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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