Web Desc
Drug Resistance and Persistence in Tuberculosis
Organizer(s): Ann M. Ginsberg and John D. McKinney
Date: May 13 - 18, 2012
Location: Speke Resort & Conference Centre, Kampala, Uganda
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by GlaxoSmithKline
Summary of Meeting:
According to the World Health Organization, over 25% of new tuberculosis cases in some subnational regions are multi-drug-resistant TB (MDR-TB) and, as of March 2010, 58 countries had reported XDR-TB (TB resistant to the major classes of both first- and second-line drugs). The Keystone Symposia meeting on Drug Resistance and Persistence in Tuberculosis aims to bring together basic and clinical researchers and public health experts from diverse backgrounds to explore the following: 1) the fundamental biology underlying genetic and phenotypic drug-resistance in TB; 2) progress in expanding capacity in high-burden settings to perform drug susceptibility testing; 3) identification of novel drug targets; 4) innovative strategies for drug discovery; and 5) advances in developing multi-drug regimens that will be effective against currently drug-resistant as well as drug-sensitive strains of M. tuberculosis. Investigators from outside the TB field will be included to provide new perspectives and stimulate fresh approaches for tackling this global public health priority.
Global Health Travel Award Deadline: December 13 2011
Scholarship Deadline: January 13 2012
Discounted Abstract Deadline: January 13 2012
Abstract Deadline: February 14 2012
Discounted Registration Deadline: March 16 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates FoundationGlaxoSmithKline
We gratefully acknowledge additional support for this conference from:
Hain Lifescience GmbH
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline / DDDW

Tibotec BVBA
$2,500 - $9,999
S. Karger AG - Journal of Innate Immunity
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI098285-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, May 13 | 3:00PM - 7:30PM
Registration
Room: Speke Lobby


Sunday, May 13 | 6:15PM - 7:15PM
Refreshments
Room: Calabash Lounge


Sunday, May 13 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Commonwealth Ballroom

Speaker 1 of 2
* Ann M. Ginsberg, BMGF, USA

Sunday, May 13 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Commonwealth Ballroom

Speaker 2 of 2
Virander Singh Chauhan, International Centre for Genetic Engineering and Biotechnology, India
MDR TB: How to Deal with a Major Global Health Challenge?

Monday, May 14 | 8:00AM - 9:00AM
Breakfast
Room: Nyanja Restaurant


Monday, May 14 | 8:00AM - 9:00AM
Poster Setup
Room: Commonwealth Ballroom


Monday, May 14 | 9:00AM - 5:00PM
Poster Viewing
Room: Commonwealth Ballroom


Monday, May 14 | 9:00AM - 12:15PM
Mechanisms of Drug Resistance (Including Lessons from Other
Fields)

Room: Commonwealth Ballroom

Speaker 1 of 7
* Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA

Monday, May 14 | 9:00AM - 12:15PM
Mechanisms of Drug Resistance (Including Lessons from Other
Fields)

Room: Commonwealth Ballroom

Speaker 2 of 7
Valerie Mizrahi, University of Cape Town, South Africa
Mechanisms Driving Mutations to Drug Resistance

Monday, May 14 | 9:00AM - 12:15PM
Mechanisms of Drug Resistance (Including Lessons from Other
Fields)

Room: Commonwealth Ballroom

Speaker 3 of 7
Adam C. Palmer, Harvard Medical School, USA
Drug Interactions and Evolution of Drug Resistance

Monday, May 14 | 9:00AM - 12:15PM
Mechanisms of Drug Resistance (Including Lessons from Other
Fields)

Room: Commonwealth Ballroom

Speaker 4 of 7
Sébastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
The Fitness Cost of Drug Resistance

Monday, May 14 | 9:00AM - 12:15PM
Mechanisms of Drug Resistance (Including Lessons from Other
Fields)

Room: Commonwealth Ballroom

Speaker 5 of 7
Moses Joloba, Makerere University, Uganda
MDR and XDR Strains

Monday, May 14 | 9:00AM - 12:15PM
Mechanisms of Drug Resistance (Including Lessons from Other
Fields)

Room: Commonwealth Ballroom

Speaker 6 of 7
Vikram Saini, University of Alabama, Birmingham, USA
Short Talk: Next-Generation Sequencing and Analysis of Cigarette Smoke-Induced Drug Resistant Mycobacterium tuberculosis Strains: Discovery of a Cigarette Smoke Signature

Monday, May 14 | 9:00AM - 12:15PM
Mechanisms of Drug Resistance (Including Lessons from Other
Fields)

Room: Commonwealth Ballroom

Speaker 7 of 7
Nataly Alvarez, Corporation for Biological Research, Colombia
Short Talk: The Structural Modeling of the Interaction between Levofloxacin and the Mycobacterium tuberculosis Gyrase Catalytic Site Sheds Light on the Mechanisms of Fluoroquinolones Resistant tuberculosis in Colombian Clinical Isolates

Monday, May 14 | 10:20AM - 10:40AM
Coffee Break
Room: Calabash Lounge


Monday, May 14 | 12:15PM - 1:00PM
Lunch
Room: Nyanja Restaurant


Monday, May 14 | 1:00PM - 3:30PM
Poster Session 1
Room: Commonwealth Ballroom


Monday, May 14 | 3:30PM - 4:00PM
Coffee Available
Room: Calabash Lounge


Monday, May 14 | 4:00PM - 6:00PM
Future of the MDR/XDR Epidemic: Progress in Diagnosis of Dru
g-Resistant TB

Room: Commonwealth Ballroom

Speaker 1 of 5
* David Alland, Rutgers University, New Jersey Medical School, USA

Monday, May 14 | 4:00PM - 6:00PM
Future of the MDR/XDR Epidemic: Progress in Diagnosis of Dru
g-Resistant TB

Room: Commonwealth Ballroom

Speaker 2 of 5
Megan Murray, Harvard Medical School, USA
Approaches to Understanding the Epidemic Dynamics of Drug Resistant TB

Monday, May 14 | 4:00PM - 6:00PM
Future of the MDR/XDR Epidemic: Progress in Diagnosis of Dru
g-Resistant TB

Room: Commonwealth Ballroom

Speaker 3 of 5
Chris Gilpin, World Health Organization, Switzerland
The Global Laboratory Initiative: Needs and Progress in Laboratory Infrastructure

Monday, May 14 | 4:00PM - 6:00PM
Future of the MDR/XDR Epidemic: Progress in Diagnosis of Dru
g-Resistant TB

Room: Commonwealth Ballroom

Speaker 4 of 5
Philippe Jacon, FIND (Foundation for Innovative New Diagnostics), Switzerland
Progress in Developing Point-of-Treatment Methods for Drug Susceptibility Testing: What’s on the Horizon?

Monday, May 14 | 4:00PM - 6:00PM
Future of the MDR/XDR Epidemic: Progress in Diagnosis of Dru
g-Resistant TB

Room: Commonwealth Ballroom

Speaker 5 of 5
David Alland, Rutgers University, New Jersey Medical School, USA

Monday, May 14 | 6:00PM - 6:00PM
On Own for Dinner


Tuesday, May 15 | 8:00AM - 9:00AM
Breakfast
Room: Nyanja Restaurant


Tuesday, May 15 | 9:00AM - 12:00PM
Persistence (Phenotypic Drug Resistance) - Including Example
s from Other Fields

Room: Commonwealth Ballroom

Speaker 1 of 8
* Valerie Mizrahi, University of Cape Town, South Africa

Tuesday, May 15 | 9:00AM - 12:00PM
Persistence (Phenotypic Drug Resistance) - Including Example
s from Other Fields

Room: Commonwealth Ballroom

Speaker 2 of 8
John D. McKinney, Swiss Federal Institute of Technology (EPFL), Switzerland
Individuality of Bacterial Responses to Antibiotics

Tuesday, May 15 | 9:00AM - 12:00PM
Persistence (Phenotypic Drug Resistance) - Including Example
s from Other Fields

Room: Commonwealth Ballroom

Speaker 3 of 8
X. Sunney Xie, Peking University, China
Persistence in Escherichia coli

Tuesday, May 15 | 9:00AM - 12:00PM
Persistence (Phenotypic Drug Resistance) - Including Example
s from Other Fields

Room: Commonwealth Ballroom

Speaker 4 of 8
Natalie Balaban, Hebrew University, Israel
Noise Amplification and Persistence

Tuesday, May 15 | 9:00AM - 12:00PM
Persistence (Phenotypic Drug Resistance) - Including Example
s from Other Fields

Room: Commonwealth Ballroom

Speaker 5 of 8
Brian Weinrick, Trudeau Institute, USA
Short Talk: A Persistence-Enhancing Transcriptional Program Coordinated by whiB6

Tuesday, May 15 | 9:00AM - 12:00PM
Persistence (Phenotypic Drug Resistance) - Including Example
s from Other Fields

Room: Commonwealth Ballroom

Speaker 6 of 8
Heather L. Torrey, Northeastern University, USA
Short Talk: Analysis of High-Persister Strains in Mycobacterium tuberculosis

Tuesday, May 15 | 9:00AM - 12:00PM
Persistence (Phenotypic Drug Resistance) - Including Example
s from Other Fields

Room: Commonwealth Ballroom

Speaker 7 of 8
Cyrielle I. Kint, University of Leuven, Belgium
Short Talk: Structure-Function Analysis of an Essential GTPase Involved in Bacterial Persistence

Tuesday, May 15 | 9:00AM - 12:00PM
Persistence (Phenotypic Drug Resistance) - Including Example
s from Other Fields

Room: Commonwealth Ballroom

Speaker 8 of 8
Veerle R. Liebens, University of Leuven, Belgium
Short Talk: New Insight into an Old Phenomenon: Extracellular Properties Determine Fluoroquinolone Tolerance in Pseudomonas aeruginosa

Tuesday, May 15 | 10:20AM - 10:40AM
Coffee Break
Room: Calabash Lounge


Tuesday, May 15 | 12:00PM - 1:00PM
Poster Setup
Room: Commonwealth Ballroom


Tuesday, May 15 | 12:00PM - 12:00PM
On Own for Lunch and Recreation


Tuesday, May 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Commonwealth Ballroom


Tuesday, May 15 | 4:30PM - 5:00PM
Coffee Available
Room: Calabash Lounge


Tuesday, May 15 | 5:00PM - 7:00PM
Progress in TB Drug Discovery
Room: Commonwealth Ballroom

Speaker 1 of 5
* Zhenkun Ma, Global Alliance for TB Drug Development, USA

Tuesday, May 15 | 5:00PM - 7:00PM
Progress in TB Drug Discovery
Room: Commonwealth Ballroom

Speaker 2 of 5
Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA
Overview of Current and Future Approaches to TB Drug Discovery

Tuesday, May 15 | 5:00PM - 7:00PM
Progress in TB Drug Discovery
Room: Commonwealth Ballroom

Speaker 3 of 5
Oren Zimhony, Kaplan Medical Center affiliated to the school of Medicine Hebrew Universit, Israel
The Challenge of Pyrazinamide: Dissecting 'Mechanism' between Sterilizing Effect, Conditions for Susceptibility and Site of Action

Tuesday, May 15 | 5:00PM - 7:00PM
Progress in TB Drug Discovery
Room: Commonwealth Ballroom

Speaker 4 of 5
David Barros, GlaxoSmithKline, Spain
TB Drug Discovery at GSK

Tuesday, May 15 | 5:00PM - 7:00PM
Progress in TB Drug Discovery
Room: Commonwealth Ballroom

Speaker 5 of 5
Claude Kirimuhuzya, Kampala International University-Western Campus, Uganda
Short Talk: Eficacy of Uganda’s Plants on Rifampicin-Resistant Tuberculosis: A Review of Research Done in Uganda since 2006

Tuesday, May 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Nyanja Restaurant


Tuesday, May 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Commonwealth Ballroom


Wednesday, May 16 | 8:00AM - 9:00AM
Breakfast
Room: Nyanja Restaurant


Wednesday, May 16 | 8:00AM - 9:00AM
Poster Setup
Room: Commonwealth Ballroom


Wednesday, May 16 | 9:00AM - 5:00PM
Poster Viewing
Room: Commonwealth Ballroom


Wednesday, May 16 | 9:00AM - 12:00PM
Novel Approaches to TB Drug Discovery
Room: Commonwealth Ballroom

Speaker 1 of 6
* Ann M. Ginsberg, BMGF, USA

Wednesday, May 16 | 9:00AM - 12:00PM
Novel Approaches to TB Drug Discovery
Room: Commonwealth Ballroom

Speaker 2 of 6
Gilla Kaplan, University of Cape Town, South Africa
Immunomodulatory Molecules as Adjuvant Chemotherapy for TB

Wednesday, May 16 | 9:00AM - 12:00PM
Novel Approaches to TB Drug Discovery
Room: Commonwealth Ballroom

Speaker 3 of 6
Kanury V. S. Rao, International Centre for Genetic Engineering and Biotechnology, India
Elucidating the Crosstalk Mechanisms that Facilitate Intra-Macrophage Survival of Mycobacterium tuberculosis

Wednesday, May 16 | 9:00AM - 12:00PM
Novel Approaches to TB Drug Discovery
Room: Commonwealth Ballroom

Speaker 4 of 6
Priscille Marie Brodin, CIIL Institut Pasteur, France
High Content Screening of M. tuberculosis Infected Macrophage as a Pre-Clinical Model for the Development of Novel Anti-Tuberculosis Drug Candidates

Wednesday, May 16 | 9:00AM - 12:00PM
Novel Approaches to TB Drug Discovery
Room: Commonwealth Ballroom

Speaker 5 of 6
John Szumowski, University of Washington, USA
Macrophage-Induced, Bacterial Efflux Pump-Mediated Drug Tolerance in Tuberculosis

Wednesday, May 16 | 9:00AM - 12:00PM
Novel Approaches to TB Drug Discovery
Room: Commonwealth Ballroom

Speaker 6 of 6
Melanie Grobbelaar, University of Stellenbosch Faculty of Health Sciences, South Africa
Short Talk: Adaptation of the Mycobacterium tuberculosis Transcriptome in Response to Rifampicin

Wednesday, May 16 | 10:20AM - 10:40AM
Coffee Break
Room: Calabash Lounge


Wednesday, May 16 | 12:00PM - 1:00PM
Lunch
Room: Nyanja Restaurant


Wednesday, May 16 | 1:00PM - 3:30PM
Poster Session 3
Room: Commonwealth Ballroom


Wednesday, May 16 | 3:30PM - 4:00PM
Coffee Available
Room: Calabash Lounge


Wednesday, May 16 | 4:00PM - 6:00PM
Novel Drug Targets
Room: Commonwealth Ballroom

Speaker 1 of 5
* Lawrence Geiter, Otsuka Pharmaceutical Development and Commercialization Inc., USA

Wednesday, May 16 | 4:00PM - 6:00PM
Novel Drug Targets
Room: Commonwealth Ballroom

Speaker 2 of 5
Zhenkun Ma, Global Alliance for TB Drug Development, USA
Target-Based Approach in Tuberculosis Drug Discovery

Wednesday, May 16 | 4:00PM - 6:00PM
Novel Drug Targets
Room: Commonwealth Ballroom

Speaker 3 of 5
Graham F. Hatfull, University of Pittsburgh, USA
Exploration and Exploitation of Mycobacteriophages

Wednesday, May 16 | 4:00PM - 6:00PM
Novel Drug Targets
Room: Commonwealth Ballroom

Speaker 4 of 5
Katarina Mikusova, Comenius University, Faculty of Natural Sciences, Slovakia
DprE1 – Past, Present and Future

Wednesday, May 16 | 4:00PM - 6:00PM
Novel Drug Targets
Room: Commonwealth Ballroom

Speaker 5 of 5
Yap J. B. Boum II, Epicentre Mbarara Research Base, Uganda
Short Talk: Thymidylate Synthase ThyX: An Excellent Target for New Anti-Tuberculosis Drugs

Wednesday, May 16 | 6:00PM - 6:00PM
On Own for Dinner


Thursday, May 17 | 8:00AM - 9:00AM
Breakfast
Room: Nyanja Restaurant


Thursday, May 17 | 9:00AM - 12:00PM
Updates on Progress in Developing Novel TB Treatments for M(
X)XDR-TB

Room: Commonwealth Ballroom

Speaker 1 of 7
* Moses Joloba, Makerere University, Uganda

Thursday, May 17 | 9:00AM - 12:00PM
Updates on Progress in Developing Novel TB Treatments for M(
X)XDR-TB

Room: Commonwealth Ballroom

Speaker 2 of 7
Myriam Haxaire, Tibotec BVBA, Belgium
TMC207 Clinical Development Status

Thursday, May 17 | 9:00AM - 12:00PM
Updates on Progress in Developing Novel TB Treatments for M(
X)XDR-TB

Room: Commonwealth Ballroom

Speaker 3 of 7
Lawrence Geiter, Otsuka Pharmaceutical Development and Commercialization Inc., USA
Clinical Development of Delamanid (OPC-67683)

Thursday, May 17 | 9:00AM - 12:00PM
Updates on Progress in Developing Novel TB Treatments for M(
X)XDR-TB

Room: Commonwealth Ballroom

Speaker 4 of 7
Daniel E. Everitt, TB Alliance, USA
Unified DS/DR Development Pathway for Novel TB Drug Regimens

Thursday, May 17 | 9:00AM - 12:00PM
Updates on Progress in Developing Novel TB Treatments for M(
X)XDR-TB

Room: Commonwealth Ballroom

Speaker 5 of 7
Derek J. Sloan, Malawi Liverpool Wellcome Trust Clinical Research Programme, Malawi
Short Talk: Bacillary Elimination Rates, Persister Phenotypes and Clinical Outcomes in a Longitudinal Study of TB Treatment in Malawi

Thursday, May 17 | 9:00AM - 12:00PM
Updates on Progress in Developing Novel TB Treatments for M(
X)XDR-TB

Room: Commonwealth Ballroom

Speaker 6 of 7
Umesh D. Gupta, National Jalma Institute for Leprosy and Other Mycobacterial Diseases, India
Short Talk: Mycobacterium indicus pranii as a Stand-Alone or Adjunct Immunotherapeutic in Treatment of Experimental Animal Tuberculosis

Thursday, May 17 | 9:00AM - 12:00PM
Updates on Progress in Developing Novel TB Treatments for M(
X)XDR-TB

Room: Commonwealth Ballroom

Speaker 7 of 7
Ann M. Ginsberg, BMGF, USA
The Ultimate Weapon Against Resistance and Persistence: Progress in Development of New TB Vaccines

Thursday, May 17 | 10:20AM - 10:40AM
Coffee Break
Room: Calabash Lounge


Thursday, May 17 | 12:00PM - 12:00PM
On Own for Lunch and Recreation


Thursday, May 17 | 4:30PM - 5:00PM
Coffee Available
Room: Calabash Lounge


Thursday, May 17 | 5:00PM - 7:00PM
Late-Breaking Session
Room: Commonwealth Ballroom

Speaker 1 of 6
* John D. McKinney, Swiss Federal Institute of Technology (EPFL), Switzerland

Thursday, May 17 | 5:00PM - 7:00PM
Late-Breaking Session
Room: Commonwealth Ballroom

Speaker 2 of 6
Sarah M. Fortune, Harvard TH Chan School of Public Health, USA
Mutation Rate/Evolution of Drug Resistance Project

Thursday, May 17 | 5:00PM - 7:00PM
Late-Breaking Session
Room: Commonwealth Ballroom

Speaker 3 of 6
Mike R. Barer, University of Leicester, UK
Evidence for Persistent Bacteria in Sputa of Antibiotic-Treated TB Patients

Thursday, May 17 | 5:00PM - 7:00PM
Late-Breaking Session
Room: Commonwealth Ballroom

Speaker 4 of 6
Pierre Ankomah, Emory University, USA
Short Talk: Two-Drug Antimicrobial Chemotherapy: A Mathematical Model and Experiments with Mycobacterium marinum

Thursday, May 17 | 5:00PM - 7:00PM
Late-Breaking Session
Room: Commonwealth Ballroom

Speaker 5 of 6
Juan Manuel Belardinelli, Colorado State University, USA
Short Talk: Mutations in the beta-Hydroxyacyl ACP Dehydratase Confer Resistance to Thiacetazone in M. tuberculosis and M. kansasii

Thursday, May 17 | 5:00PM - 7:00PM
Late-Breaking Session
Room: Commonwealth Ballroom

Speaker 6 of 6
Elizabeth Maria Streicher, Stellenbosch University, South Africa
Short Talk: Mycobacterium tuberculosis Population Structure Determines the Outcome of Genetic Based Second-Line Drug Resistance Testing

Thursday, May 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Poolside Lawn


Thursday, May 17 | 8:00PM - 11:00PM
Entertainment
Room: Poolside Lawn


Thursday, May 17 | 8:00PM - 11:00PM
Cash Bar
Room: Poolside Lawn


Friday, May 18 | 10:25AM - 10:25AM
Departure


*Session Chair.