Web Desc
The Role of Inflammation during Carcinogenesis
Organizer(s): Jeffrey W. Pollard and Laurence Egan
Date: May 20 - 25, 2012
Location: Royal Dublin Society, Dublin 4, Ireland
Organized in Collaboration with Science Foundation Ireland. Sponsored by Hoffmann-La Roche, Inc. and Pfizer Inc.
Summary of Meeting:
There is a growing appreciation that inflammation is the root cause of many cancers. Epidemiological and infectious disease literature supports this hypothesis. In addition, there is a growing body of experimental support confirming the role of inflammation in cancer initiation. However, once tumors are established, this inflammatory response changes and a set of immune cells are recruited that are immunomodulatory and not inflammatory. These types of immune cells, particularly those of the innate system, are also recruited to tumors in which there is no evidence for inflammation as a cause of tumorigenesis. This phenomenon has sometimes been called sterile inflammation. These immune cells enhance tumor progression and metastasis by promoting angiogenesis, enhancing tumor cell migration, invasion and intravasation and suppressing anti-tumor immunity. The conference will address the mechanisms behind the recruitment of the immune cells and their function, the switches in type of inflammatory responses during tumor progression and the actions of these cells in tumor promotion both at the primary and metastatic sites.
Scholarship Deadline: January 20 2012
Discounted Abstract Deadline: January 20 2012
Abstract Deadline: February 21 2012
Discounted Registration Deadline: March 20 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Hoffmann-La Roche, Inc.Pfizer Inc.Science Foundation Ireland
We gratefully acknowledge additional support for this conference from:
Biogen IdecFáilte Ireland
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
EMBO (European Molecular Biology Organization)
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, May 20 | 3:00PM - 7:30PM
Registration
Room: Concert Hall Foyer


Sunday, May 20 | 6:15PM - 7:15PM
Refreshments
Room: Hall 4


Sunday, May 20 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Concert Hall

Speaker 2 of 2
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
New Adventures of an Old Flame

Sunday, May 20 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Concert Hall

Speaker 1 of 2
* Jeffrey W. Pollard, Queen's Medical Research Institute, UK

Monday, May 21 | 7:30AM - 8:30AM
Breakfast
Room: Your Lodging Location


Monday, May 21 | 8:30AM - 11:30AM
The Microbiome and Cancer
Room: Concert Hall

Speaker 6 of 6
Pratyusha Mandal, Emory University, USA
Short Talk: Latent gammaherpesvirus Infection Induces Widespread, Interferon-Dependent DNA Damage that Synergizes with Environmental Carcinogens to Promote Aggressive Lymphoma

Monday, May 21 | 8:30AM - 11:30AM
The Microbiome and Cancer
Room: Concert Hall

Speaker 5 of 6
Eduardo Bonavita, Cancer Research UK Manchester Institute, University of Manchester, UK
Short Talk: Dual Role of Toll Interleukin-1 Receptor (IL-1R) 8 / TIR8 in Cancer

Monday, May 21 | 8:30AM - 11:30AM
The Microbiome and Cancer
Room: Concert Hall

Speaker 4 of 6
* Sergio A. Lira, Mount Sinai School of Medicine, USA
A Role for Inflammation in the Development of Intestinal Serrated Lesions?

Monday, May 21 | 8:30AM - 11:30AM
The Microbiome and Cancer
Room: Concert Hall

Speaker 3 of 6
Christian Jobin, University of Florida, USA
Role of Bacteria in Colitis-Associated Colorectal Cancer

Monday, May 21 | 8:30AM - 11:30AM
The Microbiome and Cancer
Room: Concert Hall

Speaker 2 of 6
Mathias Chamaillard, Inserm, France
Remote Control of Intestinal Tumorigenesis in Response to Commensals

Monday, May 21 | 8:30AM - 11:30AM
The Microbiome and Cancer
Room: Concert Hall

Speaker 1 of 6
Lita M. Proctor, National Human Genome Research Institute, USA
The Human Microbiome Project: An Update

Monday, May 21 | 9:40AM - 10:10AM
Coffee Break
Room: Hall 4


Monday, May 21 | 11:30AM - 11:30AM
On Own for Lunch and Recreation


Monday, May 21 | 11:30AM - 1:00PM
Poster Setup
Room: Hall 4


Monday, May 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Hall 4


Monday, May 21 | 4:30PM - 5:00PM
Coffee Available
Room: Hall 4


Monday, May 21 | 5:00PM - 7:00PM
Regulation of Inflammation in Cancer
Room: Concert Hall

Speaker 1 of 4
Grace Yi Chen, University of Michigan, USA
Nod1, A Bacterial Sensor that Regulates Inflammation and Cancer in the Gut

Monday, May 21 | 5:00PM - 7:00PM
Regulation of Inflammation in Cancer
Room: Concert Hall

Speaker 2 of 4
Michael Girardi, Yale University School of Medicine, USA
Lessons from Langerhans Cells: Cooperative Carcinogenesis

Monday, May 21 | 5:00PM - 7:00PM
Regulation of Inflammation in Cancer
Room: Concert Hall

Speaker 3 of 4
* Ian A. Blair, University of Pennsylvania, USA
Cyclooxygenases and Lipoxygenases in Cancer

Monday, May 21 | 5:00PM - 7:00PM
Regulation of Inflammation in Cancer
Room: Concert Hall

Speaker 4 of 4
Sabine Gruber, Institute for Genetics, University of Cologne, Germany
Short Talk: Obesity Abrogates IL-6 Receptor alpha Dependency of Liver Carcinogenesis via GSK-3beta Inhibition

Monday, May 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Hall 4


Monday, May 21 | 7:30PM - 10:00PM
Poster Session 1
Room: Hall 4


Tuesday, May 22 | 7:30AM - 8:30AM
Breakfast
Room: Your Lodging Location


Tuesday, May 22 | 7:30AM - 8:00AM
Poster Setup
Room: Hall 4


Tuesday, May 22 | 8:00AM - 5:00PM
Poster Viewing
Room: Hall 4


Tuesday, May 22 | 8:30AM - 11:30AM
Mechanism of Inflammation-Induced Cancer
Room: Concert Hall

Speaker 1 of 6
* Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
Manipulations of the Immune Microenvironment of Cancer

Tuesday, May 22 | 8:30AM - 11:30AM
Mechanism of Inflammation-Induced Cancer
Room: Concert Hall

Speaker 2 of 6
Rinat Abramovitch, Hadassah Hebrew University Hospital, Israel
Double Strand DNA Breaks, Chronic Inflammation and Liver Cancer

Tuesday, May 22 | 8:30AM - 11:30AM
Mechanism of Inflammation-Induced Cancer
Room: Concert Hall

Speaker 3 of 6
Kevin Struhl, Harvard Medical School, USA
An Epigenetic Switch that Links Inflammation to Cancer

Tuesday, May 22 | 8:30AM - 11:30AM
Mechanism of Inflammation-Induced Cancer
Room: Concert Hall

Speaker 4 of 6
Christopher K. Glass, University of California, San Diego, USA
Activation and Repression Mechanisms that Regulated Inflammatory Responses of Macrophages

Tuesday, May 22 | 8:30AM - 11:30AM
Mechanism of Inflammation-Induced Cancer
Room: Concert Hall

Speaker 5 of 6
Masataka Majima, Kitasato University School of Medicine, Japan
Short Talk: Roles of Prostaglandins in Enhancement of Angiogenesis and Lymphangiogenesis during the Developments of Cancers and Inflammation

Tuesday, May 22 | 8:30AM - 11:30AM
Mechanism of Inflammation-Induced Cancer
Room: Concert Hall

Speaker 6 of 6
Aideen E. Ryan, National University of Ireland Galway, Ireland
Short Talk: Targeting Colon Cancer Cell NF-kappaB Regulates Tumor-Associated Macrophage Polarization and Enhances Anti-Tumor Immune Response

Tuesday, May 22 | 9:40AM - 10:10AM
Coffee Break
Room: Hall 4


Tuesday, May 22 | 11:30AM - 12:30PM
Lunch
Room: Hall 4


Tuesday, May 22 | 12:00PM - 2:30PM
Poster Session 2
Room: Hall 4


Tuesday, May 22 | 2:30PM - 4:30PM
Workshop: Imaging of Immune Cells
Room: Concert Hall

Speaker 5 of 5
Stavros Melemenidis, Gray Institute for Radiation Biology and Oncology, UK
Development of a Combined Molecularly-Targeted and Hyperpolarized Gas Imaging Approach for Early in vivo Detection of Lung Metastasis

Tuesday, May 22 | 2:30PM - 4:30PM
Workshop: Imaging of Immune Cells
Room: Concert Hall

Speaker 4 of 5
Damya Laoui, Vrije Universiteit Brussel-VIB, Belgium
Macrophage Mannose Receptor-Specific Nanobody-Based Targeting and in vivo Imaging of Tumor-Associated Macrophages

Tuesday, May 22 | 2:30PM - 4:30PM
Workshop: Imaging of Immune Cells
Room: Concert Hall

Speaker 3 of 5
Tim S. Kees, Cold Spring Harbor Laboratory, USA
A Nanoparticle-Based Approach to Activate Macrophage Tumoricidal Activities in vivo

Tuesday, May 22 | 2:30PM - 4:30PM
Workshop: Imaging of Immune Cells
Room: Concert Hall

Speaker 2 of 5
Paul Martin, University of Bristol, UK
Live Imaging of Early Interactions between Leukocytes and Transformed Cells in Zebrafish Larvae

Tuesday, May 22 | 2:30PM - 4:30PM
Workshop: Imaging of Immune Cells
Room: Concert Hall

Speaker 1 of 5
* Claire E. Lewis, University of Sheffield Medical School, UK
Visualising Tumor-Associated Macrophages in Zebrafish: Effects of Chemotherapy and Vasculature-Damaging Agents

Tuesday, May 22 | 4:30PM - 5:00PM
Coffee Available
Room: Hall 4


Tuesday, May 22 | 5:00PM - 7:00PM
Cancer Inflammation: Mucosal Immunity as a Cause of Cancer
Room: Concert Hall

Speaker 1 of 4
* Laurence Egan, National University of Ireland, Galway, Ireland
Inflammation, DNA Methylation and Colitis-Associated Cancer

Tuesday, May 22 | 5:00PM - 7:00PM
Cancer Inflammation: Mucosal Immunity as a Cause of Cancer
Room: Concert Hall

Speaker 2 of 4
Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany
NF-kappaB and Stat3 Signaling in the Initiation and Progression of Colon Cancer

Tuesday, May 22 | 5:00PM - 7:00PM
Cancer Inflammation: Mucosal Immunity as a Cause of Cancer
Room: Concert Hall

Speaker 3 of 4
Cynthia L. Sears, Johns Hopkins University School of Medicine, USA
Gut Flora and Colon Cancer

Tuesday, May 22 | 5:00PM - 7:00PM
Cancer Inflammation: Mucosal Immunity as a Cause of Cancer
Room: Concert Hall

Speaker 4 of 4
Sergei Grivennikov, Fox Chase Cancer Center, USA
Short Talk: Cytokine Signaling Controls Tumor-Elicited Inflammation and Promotes Colorectal Cancer

Tuesday, May 22 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, May 23 | 7:30AM - 8:30AM
Breakfast
Room: Your Lodging Location


Wednesday, May 23 | 8:30AM - 11:30AM
Tumor Promotion by Inflammatory Cells
Room: Concert Hall

Speaker 1 of 4
Michele De Palma, École Polytechnique Fédérale de Lausanne, Switzerland
A MicroRNA Switch Modulates Genetic Programmes of TAMs

Wednesday, May 23 | 8:30AM - 11:30AM
Tumor Promotion by Inflammatory Cells
Room: Concert Hall

Speaker 2 of 4
Steven M. Albelda, University of Pennsylvania, USA
Role of Tumor-Associated Neutrophils in Cancer

Wednesday, May 23 | 8:30AM - 11:30AM
Tumor Promotion by Inflammatory Cells
Room: Concert Hall

Speaker 3 of 4
Johanna A. Joyce, University of Lausanne, Switzerland
Tumor-Associated Macrophages Regulate Cancer Progression and
Response to Therapy


Wednesday, May 23 | 8:30AM - 11:30AM
Tumor Promotion by Inflammatory Cells
Room: Concert Hall

Speaker 4 of 4
Neta Erez, Tel Aviv University, Israel
Cancer-Associated Fibroblasts Mediate Tumor Promoting Inflammation

Wednesday, May 23 | 9:40AM - 10:10AM
Coffee Break
Room: Hall 4


Wednesday, May 23 | 11:30AM - 1:00PM
Poster Setup
Room: Hall 4


Wednesday, May 23 | 11:30AM - 11:30AM
On Own for Lunch and Recreation


Wednesday, May 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Hall 4


Wednesday, May 23 | 4:30PM - 5:00PM
Coffee Available
Room: Hall 4


Wednesday, May 23 | 5:00PM - 7:00PM
The Evolving Inflammatory Response
Room: Concert Hall

Speaker 1 of 4
Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Monocyte and Macrophage Diversity Promotes Tumor Progression and Metastasis

Wednesday, May 23 | 5:00PM - 7:00PM
The Evolving Inflammatory Response
Room: Concert Hall

Speaker 2 of 4
Suzanne Ostrand-Rosenberg, University of Maryland, USA
Inflammation-Amplified Cross-Talk between Myeloid-Derived Suppressor Cells and Macrophages Drives Tumor Progression

Wednesday, May 23 | 5:00PM - 7:00PM
The Evolving Inflammatory Response
Room: Concert Hall

Speaker 3 of 4
* Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation and Cancer: Reprogramming the Immune Microenvironment as an Anti-Cancer Therapeutic Strategy

Wednesday, May 23 | 5:00PM - 7:00PM
The Evolving Inflammatory Response
Room: Concert Hall

Speaker 4 of 4
Metamia Ciampricotti, Netherlands Cancer Institute, Netherlands
Short Talk: Chemotherapy Response of Spontaneous Mammary Tumors is Independent of the Adaptive Immune System

Wednesday, May 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Hall 4


Wednesday, May 23 | 7:30PM - 10:00PM
Poster Session 3
Room: Hall 4


Thursday, May 24 | 7:30AM - 8:30AM
Breakfast
Room: Your Lodging Location


Thursday, May 24 | 8:30AM - 11:30AM
Clinical Correlation and Susceptibility to Cancer
Room: Concert Hall

Speaker 1 of 5
Douglas McClain Noonan, Università degli Studi dell'Insubria, Italy
Diet Derivatives and Phytochemicals in Cancer Prevention

Thursday, May 24 | 8:30AM - 11:30AM
Clinical Correlation and Susceptibility to Cancer
Room: Concert Hall

Speaker 2 of 5
* Judith Campisi, Buck Institute for Research on Aging, USA
Aging, Inflammation and Cancer

Thursday, May 24 | 8:30AM - 11:30AM
Clinical Correlation and Susceptibility to Cancer
Room: Concert Hall

Speaker 3 of 5
Tyler J. Curiel, University of Texas Health, USA
Regulatory T Cells in Cancer: Immunopathology and Therapeutic Potential

Thursday, May 24 | 8:30AM - 11:30AM
Clinical Correlation and Susceptibility to Cancer
Room: Concert Hall

Speaker 4 of 5
Randy D. Gascoyne, British Columbia Cancer Agency, Canada
Mechanisms of Immune Escape in Lymphoid Cancers

Thursday, May 24 | 8:30AM - 11:30AM
Clinical Correlation and Susceptibility to Cancer
Room: Concert Hall

Speaker 5 of 5
Nancy J. Boudreau, NCI, National Institutes of Health, USA
Short Talk: Inhibition of Tumor Progression by HoxA5

Thursday, May 24 | 9:40AM - 10:10AM
Coffee Break
Room: Hall 4


Thursday, May 24 | 11:30AM - 11:30AM
On Own for Lunch and Recreation


Thursday, May 24 | 4:30PM - 5:00PM
Coffee Available
Room: Hall 4


Thursday, May 24 | 5:00PM - 6:10PM
Inflammation as Therapy
Room: Concert Hall

Speaker 1 of 1
* Glenn Dranoff, Novartis Institutes for BioMedical Research, USA
Mechanisms of Protective Tumor Immunity

Thursday, May 24 | 6:10PM - 7:15PM
Closing Keynote Address
Room: Concert Hall

Speaker 1 of 2
* Laurence Egan, National University of Ireland, Galway, Ireland
Closing Remarks

Thursday, May 24 | 6:10PM - 7:15PM
Closing Keynote Address
Room: Concert Hall

Speaker 2 of 2
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
TLRs as Therapeutic Targets in Inflammation and Cancer

Thursday, May 24 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Hall 4


Thursday, May 24 | 8:00PM - 11:00PM
Entertainment
Room: Hall 4


Thursday, May 24 | 8:00PM - 11:00PM
Cash Bar
Room: Hall 4


Friday, May 25 | 10:25AM - 10:25AM
Departure


*Session Chair.