Web Desc
Proteomics, Interactomes
Organizer(s): Matthias Mann, Rudolf H. Aebersold and Mathias Uhlén
Date: May 07 - 12, 2012
Location: Clarion Hotel Sign, Stockholm, Sweden
Organized in collaboration with Knut and Alice Wallenberg Foundation and Science for Life Laboratory - Stockholm
Summary of Meeting:
This Keystone Symposia conference will bring together world-leading researchers in the burgeoning field of proteomics, which is the large-scale study of the expressed proteins in biological systems. In comparison to genomics, proteomics has historically been limited by the available technology. However, this has now changed as the field has matured considerably over the last few years. Indeed, the proteomics field is at a critical junction, where very powerful technologies are now at our disposal. However, often the creativity evident within the proteomics disciplines does not extend to the creation of strategies that combine different approaches to study cellular phenomena. For instance, structural biologists use electron tomography of the entire cell and combine this with mass spectrometry to obtain a view of protein complexes or ‘machineries’ that could not be achieved by each field working in isolation. The meeting will be unique in bringing together researchers from a diverse set of backgrounds that have now begun to transcend the boundaries of single-technology approaches. This conference will address how to make best biological, biotechnology and clinical use of the tremendous opportunities that these technologies now provide. The speakers will lay out the achievements and the challenges of each field and illustrate the power of proteomics with specific cell biological or clinical applications. Importantly, many of the speakers will outline how they have begun to combine fundamentally different proteomics technologies to address biological questions. Participants can then together discuss and devise novel proteomic approaches to many biological and clinical questions.
Scholarship Deadline: January 9 2012
Discounted Abstract Deadline: January 9 2012
Abstract Deadline: February 9 2012
Discounted Registration Deadline: March 8 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Science for Life Laboratory - Stockholm
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.LabomeMolecular and Cellular ProteomicsThermo ScientificKnut and Alice Wallenberg Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

EMBO Young Investigator Programme
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
SAGE Publications
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, May 07 | 3:00PM - 7:30PM
Registration
Room: Foyer


Monday, May 07 | 6:15PM - 7:15PM
Refreshments
Room: Foyer


Monday, May 07 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: B 1-2

Speaker 1 of 1
Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA
Deciphering Complex Protein Folding Diseases

Tuesday, May 08 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Tuesday, May 08 | 7:30AM - 8:30AM
Poster Setup
Room: B3


Tuesday, May 08 | 8:30AM - 5:00PM
Poster Viewing
Room: B3


Tuesday, May 08 | 8:30AM - 11:30AM
Genomics Meets Proteomics
Room: B 1-2

Speaker 1 of 6
* Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland

Tuesday, May 08 | 8:30AM - 11:30AM
Genomics Meets Proteomics
Room: B 1-2

Speaker 2 of 6
Daniel R. Larson, NCI, National Institutes of Health, USA
Single Cell Observation of Transcription and Implication for the Proteome

Tuesday, May 08 | 8:30AM - 11:30AM
Genomics Meets Proteomics
Room: B 1-2

Speaker 3 of 6
Brenda J. Andrews, University of Toronto, Canada
Global Protein Localization and Flux Maps in Yeast

Tuesday, May 08 | 8:30AM - 11:30AM
Genomics Meets Proteomics
Room: B 1-2

Speaker 4 of 6
Matthias Selbach, Max Delbrück Center for Molecular Medicine, Germany
EMBO Young Investigator Lecture: Investigating mRNA and Protein Dynamics by Parallel Metabolic Pulse Labeling

Tuesday, May 08 | 8:30AM - 11:30AM
Genomics Meets Proteomics
Room: B 1-2

Speaker 5 of 6
Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
Evolutionary Plasticity of the Protein Interaction Network that Regulates mRNA Stability

Tuesday, May 08 | 8:30AM - 11:30AM
Genomics Meets Proteomics
Room: B 1-2

Speaker 6 of 6
Martin Kussmann, Vydiant, Switzerland
Short Talk: Nutrigenomics: Where Proteomics Meets Genomics

Tuesday, May 08 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer/B3


Tuesday, May 08 | 11:30AM - 12:30PM
Lunch
Room: Foyer/B3


Tuesday, May 08 | 12:00PM - 2:30PM
Poster Session 1
Room: B3


Tuesday, May 08 | 2:30PM - 3:00PM
Coffee Available
Room: Foyer/B3


Tuesday, May 08 | 3:00PM - 5:00PM
The Complexity of the Proteome
Room: B 1-2

Speaker 1 of 5
* Mathias Uhlen, KTH Royal Inst of Technology, Sweden

Tuesday, May 08 | 3:00PM - 5:00PM
The Complexity of the Proteome
Room: B 1-2

Speaker 2 of 5
Jonathan S. Weissman, Whitehead Institute and MIT, USA
Defining Mammalian Proteomes though Ribosome Profiling

Tuesday, May 08 | 3:00PM - 5:00PM
The Complexity of the Proteome
Room: B 1-2

Speaker 3 of 5
Pavel A. Pevzner, University of California, San Diego, USA
MS-GF+: From Specialized to Universal Database Search Tools for Mass Spectrometry

Tuesday, May 08 | 3:00PM - 5:00PM
The Complexity of the Proteome
Room: B 1-2

Speaker 4 of 5
Amos Bairoch, University of Geneva, Switzerland
Mapping the Human Proteome Complexity in neXtProt

Tuesday, May 08 | 3:00PM - 5:00PM
The Complexity of the Proteome
Room: B 1-2

Speaker 5 of 5
Sina Ghaemmaghami, University of Rochester, USA
Short Talk: Global Analysis of Protein Turnover in Mice

Tuesday, May 08 | 5:00PM - 5:00PM
On Own for Dinner


Wednesday, May 09 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Wednesday, May 09 | 8:30AM - 11:30AM
Protein Complexes and Interactions
Room: B 1-2

Speaker 1 of 6
* Matthias Selbach, Max Delbrück Center for Molecular Medicine, Germany

Wednesday, May 09 | 8:30AM - 11:30AM
Protein Complexes and Interactions
Room: B 1-2

Speaker 2 of 6
Luis Serrano, Centre for Genomic Regulation, Spain
Mycoplasma pneumoniae Proteome Composition and Dynamics

Wednesday, May 09 | 8:30AM - 11:30AM
Protein Complexes and Interactions
Room: B 1-2

Speaker 3 of 6
Carol V. Robinson, University of Oxford, UK
Mass Spectrometry from Micelles to Motors

Wednesday, May 09 | 8:30AM - 11:30AM
Protein Complexes and Interactions
Room: B 1-2

Speaker 4 of 6
Anne-Claude Gavin, European Molecular Biology Laboratory, Germany
Expanding the Interaction Space: Protein-Metabolite Networks

Wednesday, May 09 | 8:30AM - 11:30AM
Protein Complexes and Interactions
Room: B 1-2

Speaker 5 of 6
Jyoti Choudhary, Institute of Cancer Research, UK
Protein Interaction Studies by Quantitative MS

Wednesday, May 09 | 8:30AM - 11:30AM
Protein Complexes and Interactions
Room: B 1-2

Speaker 6 of 6
Ankur Jain, University of California, San Francisco, USA
Short Talk: Probing Cellular Protein Complexes via Single Molecule Pull-Down

Wednesday, May 09 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer/B3


Wednesday, May 09 | 11:30AM - 1:00PM
Poster Setup
Room: B3


Wednesday, May 09 | 11:30AM - 11:30AM
On Own for Lunch and Recreation


Wednesday, May 09 | 1:00PM - 10:00PM
Poster Viewing
Room: B3


Wednesday, May 09 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer/B3


Wednesday, May 09 | 5:00PM - 7:00PM
The Proteome in Space and Time
Room: B 1-2

Speaker 1 of 5
* Carol V. Robinson, University of Oxford, UK

Wednesday, May 09 | 5:00PM - 7:00PM
The Proteome in Space and Time
Room: B 1-2

Speaker 2 of 5
Mathias Uhlen, KTH Royal Inst of Technology, Sweden
A Human Protein Atlas

Wednesday, May 09 | 5:00PM - 7:00PM
The Proteome in Space and Time
Room: B 1-2

Speaker 3 of 5
Angus I. Lamond, University of Dundee, UK
Molecular and Cellular Proteomics Lecture: Superexperiments and the System-Wide Analysis of Protein Properties in Cell Biology

Wednesday, May 09 | 5:00PM - 7:00PM
The Proteome in Space and Time
Room: B 1-2

Speaker 4 of 5
Kathryn S. Lilley, University of Cambridge, UK
Organelle Proteomics: Tools to Establish a Global Picture of Protein Subcellular Localization

Wednesday, May 09 | 5:00PM - 7:00PM
The Proteome in Space and Time
Room: B 1-2

Speaker 5 of 5
Akira Chiba, University of Miami, USA
Short Talk: The isPIN Project: Imaging-Based Proteomic Maps of Cells in vivo

Wednesday, May 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer/B3


Wednesday, May 09 | 7:30PM - 10:00PM
Poster Session 2
Room: B3


Thursday, May 10 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Thursday, May 10 | 8:30AM - 5:00PM
Poster Viewing
Room: B3


Thursday, May 10 | 8:30AM - 11:30AM
Protein Modification and Activity and Proteomics Technology
Room: B 1-2

Speaker 1 of 6
* Walter Kolch, University College Dublin, Ireland

Thursday, May 10 | 8:30AM - 11:30AM
Protein Modification and Activity and Proteomics Technology
Room: B 1-2

Speaker 2 of 6
Benjamin F. Cravatt III, The Scripps Research Institute, USA
Proteome-Wide Activity Profiling

Thursday, May 10 | 8:30AM - 11:30AM
Protein Modification and Activity and Proteomics Technology
Room: B 1-2

Speaker 3 of 6
Matthias Mann, Max Planck Institute of Biochemistry, Germany
Large-Scale Analysis of Post-Translational Modifications

Thursday, May 10 | 8:30AM - 11:30AM
Protein Modification and Activity and Proteomics Technology
Room: B 1-2

Speaker 4 of 6
Rong Zeng, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Highly-Sensitive Enrichment and Quantification of Islet Phosphoproteome Unveiled Extensive Post-Translational Regulation in Islet Function

Thursday, May 10 | 8:30AM - 11:30AM
Protein Modification and Activity and Proteomics Technology
Room: B 1-2

Speaker 5 of 6
Albert J.R. Heck, Utrecht University, Netherlands
Quantification Methods in MS-Based Proteomics

Thursday, May 10 | 8:30AM - 11:30AM
Protein Modification and Activity and Proteomics Technology
Room: B 1-2

Speaker 6 of 6
Haruna Imamura, Kyoto University, Japan
Short Talk: Toward Comprehensive Analysis of Kinase/Substrate Pairs by in vitro Kinase Assay Coupled with Phosphoproteomics

Thursday, May 10 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer/B3


Thursday, May 10 | 11:30AM - 12:30PM
Lunch
Room: Foyer/B3


Thursday, May 10 | 12:00PM - 2:30PM
Poster Session 3
Room: B3


Thursday, May 10 | 2:30PM - 3:00PM
Coffee Available
Room: Foyer/B3


Thursday, May 10 | 3:00PM - 5:00PM
Cell Signaling Probed by Proteomics
Room: B 1-2

Speaker 1 of 5
* Angus I. Lamond, University of Dundee, UK

Thursday, May 10 | 3:00PM - 5:00PM
Cell Signaling Probed by Proteomics
Room: B 1-2

Speaker 2 of 5
Walter Kolch, University College Dublin, Ireland
Deciphering Signal Transduction Networks by Proteomics and Mathematical Modeling

Thursday, May 10 | 3:00PM - 5:00PM
Cell Signaling Probed by Proteomics
Room: B 1-2

Speaker 3 of 5
Michal Sharon, Weizmann Institute of Science, Israel
Regulating the 20S Proteasome: A Mass Spectrometry Perspective

Thursday, May 10 | 3:00PM - 5:00PM
Cell Signaling Probed by Proteomics
Room: B 1-2

Speaker 4 of 5
Arminja N. Kettenbach, Dartmouth Medical School, USA
Short Talk: Deciphering Polo-Like Kinase Signaling in Mitosis by Interactome and Substratome Studies

Thursday, May 10 | 3:00PM - 5:00PM
Cell Signaling Probed by Proteomics
Room: B 1-2

Speaker 5 of 5
Leonard J. Foster, University of British Columbia, Canada
Short Talk: Monitoring the Response of the Interactome to Bacterial Infection using Size Exclusion Chromatography and SILAC

Thursday, May 10 | 5:00PM - 5:00PM
On Own for Dinner


Friday, May 11 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Friday, May 11 | 8:30AM - 11:30AM
Proteomics of Ubiquitin and Ubiquitin-Like Modifications
Room: B 1-2

Speaker 1 of 5
* Matthias Mann, Max Planck Institute of Biochemistry, Germany

Friday, May 11 | 8:30AM - 11:30AM
Proteomics of Ubiquitin and Ubiquitin-Like Modifications
Room: B 1-2

Speaker 2 of 5
Chunaram Choudhary, University of Copenhagen, Denmark
Quantitative Proteomics of Ubiquitylation and Its Crosstalk with Acetylation

Friday, May 11 | 8:30AM - 11:30AM
Proteomics of Ubiquitin and Ubiquitin-Like Modifications
Room: B 1-2

Speaker 3 of 5
Wolfgang P. Baumeister, Max Planck Institute of Biochemistry, Germany
Molecular Architecture of the 26S Proteasome Holocomplex Determined by an Integrative Approach

Friday, May 11 | 8:30AM - 11:30AM
Proteomics of Ubiquitin and Ubiquitin-Like Modifications
Room: B 1-2

Speaker 4 of 5
Ronald T. Hay, University of Dundee, UK
System Wide Analysis of SUMO Modification in Response to Stress

Friday, May 11 | 8:30AM - 11:30AM
Proteomics of Ubiquitin and Ubiquitin-Like Modifications
Room: B 1-2

Speaker 5 of 5
Veronica G. Anania, Genentech, Inc., USA
Short Talk: Evidence for Unconventional Ubiquitination in ER-Associated Degradation

Friday, May 11 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer/B3


Friday, May 11 | 11:30AM - 11:30AM
On Own for Lunch and Recreation


Friday, May 11 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer/B3


Friday, May 11 | 5:00PM - 7:00PM
Targeted Proteomics
Room: B 1-2

Speaker 1 of 5
* Albert J.R. Heck, Utrecht University, Netherlands

Friday, May 11 | 5:00PM - 7:00PM
Targeted Proteomics
Room: B 1-2

Speaker 2 of 5
Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Measuring Proteomes and Systems Biology

Friday, May 11 | 5:00PM - 7:00PM
Targeted Proteomics
Room: B 1-2

Speaker 3 of 5
Roman A. Zubarev, Karolinska Institutet, Sweden
Proteomics Study of Alzheimer's Disease Mechanism

Friday, May 11 | 5:00PM - 7:00PM
Targeted Proteomics
Room: B 1-2

Speaker 4 of 5
Ulf Landegren, Uppsala University, Sweden
Highly Sensitive Protein Analysis by Proximity Ligation

Friday, May 11 | 5:00PM - 7:00PM
Targeted Proteomics
Room: B 1-2

Speaker 5 of 5
Martin Beck, European Molecular Biology Laboratory, Germany
Short Talk: Investigating Human Nuclear Pore Composition by Targeted Mass Spectrometry

Friday, May 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: B 2-3


Friday, May 11 | 8:00PM - 11:00PM
Entertainment
Room: B 2-3


Friday, May 11 | 8:00PM - 11:00PM
Cash Bar
Room: B 2-3


Saturday, May 12 | 10:25AM - 10:25AM
Departure


*Session Chair.