Web Desc
Fungal Pathogens: From Basic Biology to Drug Discovery
joint with Drug Discovery for Protozoan Parasites
Organizer(s): Joseph Heitman, John Taylor and Leah E. Cowen
Date: January 15 - 20, 2012
Location: Santa Fe Community Convention Center, Santa Fe, NM, USA
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation.
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Summary of Meeting:
The aim of this meeting is to bring together the academic, medical and pharmaceutical communities focused on fungal microbial pathogens of humans and other animals to illustrate common themes, and therapeutic, diagnostic and preventive opportunities. We seek to bridge both basic and physician-scientists working on the pathogenic microbe (via genetics, cell biology, genomics) and the host (immunology, including both innate and adaptive immunity). With respect to therapeutics, the emphasis is on developed as well as novel therapeutics, including both drugs and vaccines. A key aspect is to bridge the communities working on the diversity of fungi that infect humans and those working on the chytrid outbreak causing amphibian decline and extinctions. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Drug Discovery for Protozoan Parasites, which will share the keynote address and two plenary sessions with this meeting.
Global Health Travel Award Deadline: August 16 2011
Scholarship Deadline: September 19 2011
Discounted Abstract Deadline: September 19 2011
Abstract Deadline: October 19 2011
Discounted Registration Deadline: November 15 2011
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates Foundation
We gratefully acknowledge additional support for this conference from:
Amplyx Pharmaceuticals, Inc.
Department of Molecular Genetics and Microbiology, Duke University Medical Center
OneWorld HealthProcter & Gamble Company
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Anacor Pharmaceuticals, Inc.

Scynexis, Inc.


Joseph Heitman

Adriana Secatto Sarti
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI098158-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 15 | 3:00PM - 7:30PM
Registration
Room: Sweeney Ballroom Foyer


Sunday, January 15 | 6:15PM - 7:15PM
Refreshments
Room: Sweeney Ballroom F


Sunday, January 15 | 7:15PM - 7:30PM
Welcoming Remarks (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 6
Norman C. Waters, United States Military Academy, USA

Sunday, January 15 | 7:15PM - 7:30PM
Welcoming Remarks (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 6
Frederick S. Buckner, University of Washington, USA

Sunday, January 15 | 7:15PM - 7:30PM
Welcoming Remarks (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 6
* Vicky M. Avery, Griffith University, Australia

Sunday, January 15 | 7:15PM - 7:30PM
Welcoming Remarks (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 6
Joseph Heitman, Duke University, USA

Sunday, January 15 | 7:15PM - 7:30PM
Welcoming Remarks (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 6
John Taylor, University of California, Berkeley, USA

Sunday, January 15 | 7:15PM - 7:30PM
Welcoming Remarks (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 6
Leah E. Cowen, University of Toronto, Canada

Sunday, January 15 | 7:30PM - 9:00PM
Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 4
* Norman C. Waters, United States Military Academy, USA

Sunday, January 15 | 7:30PM - 9:00PM
Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 4
Dennis E. Kyle, University of Georgia, USA
Managing Risk and Exploiting Success in Antiprotozoan Drug Development

Sunday, January 15 | 7:30PM - 9:00PM
Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 4
* John Taylor, University of California, Berkeley, USA

Sunday, January 15 | 7:30PM - 9:00PM
Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 4
Arturo Casadevall, Albert Einstein College of Medicine, USA
On Fungal Virulence

Monday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney Ballroom F


Monday, January 16 | 7:30AM - 8:00AM
Poster Setup
Room: Sweeney Ballroom F


Monday, January 16 | 8:00AM - 5:00PM
Poster Viewing
Room: Sweeney Ballroom F


Monday, January 16 | 8:00AM - 11:15AM
Mechanisms of Virulence
Room: Sweeney Ballroom C-E

Speaker 1 of 7
* Arturo Casadevall, Albert Einstein College of Medicine, USA

Monday, January 16 | 8:00AM - 11:15AM
Mechanisms of Virulence
Room: Sweeney Ballroom C-E

Speaker 2 of 7
Robin C. May, University of Birmingham, UK
Fungus-Phagocyte Interactions: Understanding Fungal Virulence in vitro, in vivo and in Fish-o

Monday, January 16 | 8:00AM - 11:15AM
Mechanisms of Virulence
Room: Sweeney Ballroom C-E

Speaker 3 of 7
Kirsten Nielsen, University of Minnesota, USA
Short Talk: Cryptococcal Titan Cell Formation Affects Interactions with the Host and Subsequent Pathogenesis

Monday, January 16 | 8:00AM - 11:15AM
Mechanisms of Virulence
Room: Sweeney Ballroom C-E

Speaker 4 of 7
William E. Goldman, University of North Carolina at Chapel Hill, USA
Intracellular Survival Strategies of Histoplasma capsulatum

Monday, January 16 | 8:00AM - 11:15AM
Mechanisms of Virulence
Room: Sweeney Ballroom C-E

Speaker 5 of 7
Nuri Rodriguez Del Val, University of Puerto Rico, USA
An RNAi and Yeast Two-Hybrid Study of Calcium/Calmodulin Kinase1 and its Relationship to Thermotolerance and HSP90 in Sporothrix schencki

Monday, January 16 | 8:00AM - 11:15AM
Mechanisms of Virulence
Room: Sweeney Ballroom C-E

Speaker 6 of 7
Melanie T. Cushion, University of Cincinnati College of Medicine, USA
Stealth and Opportunism: Strategies for Survival of Pneumocystis within the Mammalian Lung

Monday, January 16 | 8:00AM - 11:15AM
Mechanisms of Virulence
Room: Sweeney Ballroom C-E

Speaker 7 of 7
Robert A. Cramer, Montana State University, USA
Short Talk: Defining the Hypoxia Response of Aspergillus fumigatus: Implications for Fungal Pathogenesis and Antifungal Drugs

Monday, January 16 | 8:00AM - 11:15AM
Drug Resistance I
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 1 of 7
* Pradipsinh K. Rathod, University of Washington, USA


Monday, January 16 | 8:00AM - 11:15AM
Drug Resistance I
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 2 of 7
Philip J. Rosenthal, University of California, San Francisco, USA
Selection for Decreased Sensitivity to Artemisinin Partner Drugs


Monday, January 16 | 8:00AM - 11:15AM
Drug Resistance I
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 3 of 7
Qin Cheng, Australian Army Malaria Institute, Australia
Artemisinin Induced Dormancy and Resistance in Plasmodium falciparum in vitro


Monday, January 16 | 8:00AM - 11:15AM
Drug Resistance I
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 4 of 7
David A. Fidock, Columbia University Medical Center, USA
Balancing Drug Resistance and Fitness via Compensatory Mutations in the Plasmodium falciparum Chloroquine Resistance Transporter


Monday, January 16 | 8:00AM - 11:15AM
Drug Resistance I
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 5 of 7
Rentala Madhubala, Jawaharlal Nehru University, India
A Comparative Proteomics Approach to Understand the Mode of Action and Mechanism of Drug Resistance in Leishmania donovani


Monday, January 16 | 8:00AM - 11:15AM
Drug Resistance I
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 6 of 7
Leann M. Tilley, University of Melbourne, Australia
Short Talk: Potent Artemisinin Activity against Plasmodium falciparum Requires Hemoglobin Uptake and Digestion


Monday, January 16 | 8:00AM - 11:15AM
Drug Resistance I
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 7 of 7
Dylan R. Pillai, University of Calgary, Canada
Short Talk: Reversing Antimalarial Resistance by Targeting Plasmodium falciparum Heat Shock Protein (PfHsp)90


Monday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney Ballroom F


Monday, January 16 | 11:15AM - 12:00PM
Lunch
Room: Sweeney Ballroom F


Monday, January 16 | 12:00PM - 2:30PM
Poster Session 1
Room: Sweeney Ballroom F


Monday, January 16 | 2:30PM - 4:30PM
Workshop 1: NIH Funding Opportunities (Joint)
Room: Sweeney Ballroom C-E


Monday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom F


Monday, January 16 | 5:00PM - 7:00PM
Host Responses to Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Annika E. Scheynius, Karolinska Institutet, Sweden

Monday, January 16 | 5:00PM - 7:00PM
Host Responses to Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Aimee K. Zaas, Duke University Medical Center, USA
Host Gene Expression Response to Fungal Infection

Monday, January 16 | 5:00PM - 7:00PM
Host Responses to Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Gordon D. Brown, University of Aberdeen, UK
Immunity to Fungal Infections, Innate and Adaptive?

Monday, January 16 | 5:00PM - 7:00PM
Host Responses to Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Paul L. Fidel, Jr., Louisiana State University Health Science Center, USA
Host Defense Against Mucosal Candida Infections: Opportunities for New Immunotherapeutics

Monday, January 16 | 5:00PM - 7:00PM
Host Responses to Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Kimberly Gerik, Washington University School of Medicine, USA
Short Talk: Chitinases – Pathogen Signaling and Host Response to C. neoformans

Monday, January 16 | 5:00PM - 7:15PM
Drug Target Identification, Validation and Screening
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 1 of 6
* Don L. Gardiner, Queensland Institute of Medical Research, Australia


Monday, January 16 | 5:00PM - 7:15PM
Drug Target Identification, Validation and Screening
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 2 of 6
Geoffrey Ian McFadden, University of Melbourne, Australia
Life Cycle Studies to Identify When and Where Malaria Parasites are Vulnerable


Monday, January 16 | 5:00PM - 7:15PM
Drug Target Identification, Validation and Screening
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 3 of 6
Emily Derbyshire, Duke University, USA
Efforts to Target and Disrupt Liver Stage Development of the Malarial Parasite


Monday, January 16 | 5:00PM - 7:15PM
Drug Target Identification, Validation and Screening
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 4 of 6
William A. Petri, Jr., University of Virginia, USA
Transmembrane Kinases of Entamoeba histolytica


Monday, January 16 | 5:00PM - 7:15PM
Drug Target Identification, Validation and Screening
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 5 of 6
Norman C. Waters, United States Military Academy, USA
Short Talk: Targeting the Cell Cycle Machinery of Plasmodium falciparum


Monday, January 16 | 5:00PM - 7:15PM
Drug Target Identification, Validation and Screening
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 6 of 6
Audrey R. Odom, Washington University School of Medicine, USA
Short Talk: Targeting Methylerythritol Cytidyltransferase (IspD) for Antimalarial Drug Discovery


Monday, January 16 | 7:00PM - 7:00PM
On Own for Dinner


Tuesday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney Ballroom F


Tuesday, January 17 | 8:00AM - 11:30AM
Drug Discovery for Eukaryotic Pathogens and Parasites (Joint
)

Room: Sweeney Ballroom A-E

Speaker 1 of 9
* Meg Phillips, University of Texas Southwestern Medical Center, USA

Tuesday, January 17 | 8:00AM - 11:30AM
Drug Discovery for Eukaryotic Pathogens and Parasites (Joint
)

Room: Sweeney Ballroom A-E

Speaker 2 of 9
* Audrey R. Odom, Washington University School of Medicine, USA

Tuesday, January 17 | 8:00AM - 11:30AM
Drug Discovery for Eukaryotic Pathogens and Parasites (Joint
)

Room: Sweeney Ballroom A-E

Speaker 3 of 9
Leah E. Cowen, University of Toronto, Canada
New Therapeutic Strategies for Fungal Disease Based on Combinatorial Control

Tuesday, January 17 | 8:00AM - 11:30AM
Drug Discovery for Eukaryotic Pathogens and Parasites (Joint
)

Room: Sweeney Ballroom A-E

Speaker 4 of 9
Dickon Alley, Anacor Pharmaceuticals, Inc., USA
Boron-based Agents for Fungal and Protozoan Infections

Tuesday, January 17 | 8:00AM - 11:30AM
Drug Discovery for Eukaryotic Pathogens and Parasites (Joint
)

Room: Sweeney Ballroom A-E

Speaker 5 of 9
Xuewen Pan, Baylor College of Medicine, USA
Short Talk: Novel Functional Genomics Approaches for Drug Target Identification and Validation

Tuesday, January 17 | 8:00AM - 11:30AM
Drug Discovery for Eukaryotic Pathogens and Parasites (Joint
)

Room: Sweeney Ballroom A-E

Speaker 6 of 9
Frederick S. Buckner, University of Washington, USA
Sterol 14-Demethylase Inhibitors for Chagas Disease

Tuesday, January 17 | 8:00AM - 11:30AM
Drug Discovery for Eukaryotic Pathogens and Parasites (Joint
)

Room: Sweeney Ballroom A-E

Speaker 7 of 9
Andrew P. Waters, University of Glasgow, UK
Commitment to sexual development – towards an understanding of a molecular mechanism.

Tuesday, January 17 | 8:00AM - 11:30AM
Drug Discovery for Eukaryotic Pathogens and Parasites (Joint
)

Room: Sweeney Ballroom A-E

Speaker 8 of 9
Dominic Hoepfner, Novartis Institutes for BioMedical Research, Switzerland
Short Talk: Cladosporin, a Natural Product with Antifungal and Antimalarial Activity Targets lysyl-tRNA Synthetase

Tuesday, January 17 | 8:00AM - 11:30AM
Drug Discovery for Eukaryotic Pathogens and Parasites (Joint
)

Room: Sweeney Ballroom A-E

Speaker 9 of 9
Doron C. Greenbaum, University of Pennsylvania, USA
Short Talk: Small Molecule Mimics of Antimicrobial Peptides as Antimalarials

Tuesday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney Ballroom F


Tuesday, January 17 | 11:30AM - 1:00PM
Poster Setup
Room: Sweeney Ballroom F


Tuesday, January 17 | 11:30AM - 11:30AM
On Own for Lunch and Recreation


Tuesday, January 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney Ballroom F


Tuesday, January 17 | 2:30PM - 4:30PM
Workshop 2: Publishing (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 11
Lakshmi Goyal, Cell Press, USA

Tuesday, January 17 | 2:30PM - 4:30PM
Workshop 2: Publishing (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 11
Arturo Casadevall, Albert Einstein College of Medicine, USA

Tuesday, January 17 | 2:30PM - 4:30PM
Workshop 2: Publishing (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 11
Aaron P. Mitchell, Carnegie Mellon University, USA

Tuesday, January 17 | 2:30PM - 4:30PM
Workshop 2: Publishing (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 11
Meg Phillips, University of Texas Southwestern Medical Center, USA

Tuesday, January 17 | 2:30PM - 4:30PM
Workshop 2: Publishing (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 11
Kevin J. Saliba, Australian National University, Australia

Tuesday, January 17 | 2:30PM - 4:30PM
Workshop 2: Publishing (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 11
Joseph Heitman, Duke University, USA

Tuesday, January 17 | 2:30PM - 4:30PM
Workshop 2: Publishing (Joint)
Room: Sweeney Ballroom A-E

Speaker 7 of 11
Alexander D. Johnson, University of California, San Francisco, USA

Tuesday, January 17 | 2:30PM - 4:30PM
Workshop 2: Publishing (Joint)
Room: Sweeney Ballroom A-E

Speaker 8 of 11
Tamara L. Doering, Washington University Medical School, USA

Tuesday, January 17 | 2:30PM - 4:30PM
Workshop 2: Publishing (Joint)
Room: Sweeney Ballroom A-E

Speaker 9 of 11
Judith G. Berman, University of Minnesota, USA

Tuesday, January 17 | 2:30PM - 4:30PM
Workshop 2: Publishing (Joint)
Room: Sweeney Ballroom A-E

Speaker 10 of 11
Tom Edlind, Drexel University College of Medicine, USA

Tuesday, January 17 | 2:30PM - 4:30PM
Workshop 2: Publishing (Joint)
Room: Sweeney Ballroom A-E

Speaker 11 of 11
Leah E. Cowen, University of Toronto, Canada

Tuesday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom F


Tuesday, January 17 | 5:00PM - 7:00PM
Evolution and Comparative Genomics of Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Charles W. Saunders, USA

Tuesday, January 17 | 5:00PM - 7:00PM
Evolution and Comparative Genomics of Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Jim Kronstad, University of British Columbia, Canada
Pathogenic Basidiomycetes: Metabolic Adaptation and Virulence Factor Expression

Tuesday, January 17 | 5:00PM - 7:00PM
Evolution and Comparative Genomics of Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Emily Troemel, University of California, San Diego, USA
Non-lytic Escape of Microsporidia from C. elegans Intestinal Cells

Tuesday, January 17 | 5:00PM - 7:00PM
Evolution and Comparative Genomics of Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Axel A. Brakhage, Friedrich Schiller University, Germany
Dermatophyte Genomics and Secondary Metabolites Involved in Fungal Pathogenicity

Tuesday, January 17 | 5:00PM - 7:00PM
Evolution and Comparative Genomics of Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Annika E. Scheynius, Karolinska Institutet, Sweden
Short Talk: The Basidiomycete Malassezia Species Complex – A Genomic Platform to Elucidate Host-Fungal Interactions Involved in Common Skin Disorders

Tuesday, January 17 | 5:00PM - 7:15PM
Hit to Lead Identification
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 1 of 6
* Paul G. Wyatt, University of Dundee, UK


Tuesday, January 17 | 5:00PM - 7:15PM
Hit to Lead Identification
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 2 of 6
Michael Riscoe, Oregon Health & Science University, USA
Revisiting Historical Leads for Clues to the Design of Future Antimalarial Drugs.


Tuesday, January 17 | 5:00PM - 7:15PM
Hit to Lead Identification
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 3 of 6
Bakela Nare, SCYNEXIS, Inc., USA
Development of Oxaborole Compounds for Human African Trypanosomiasis


Tuesday, January 17 | 5:00PM - 7:15PM
Hit to Lead Identification
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 4 of 6
Richard Glynne, Genomics Institute of the Novartis Research Foundation, USA
High-Throughput Whole-Cell Screening against Trypanosomatids


Tuesday, January 17 | 5:00PM - 7:15PM
Hit to Lead Identification
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 5 of 6
Richard W. Heidebrecht, Jr., Broad Institute, USA
Short Talk: Identification of a Novel Lead for the Treatment of Malaria via Diversity Oriented Synthesis


Tuesday, January 17 | 5:00PM - 7:15PM
Hit to Lead Identification
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 6 of 6
Mark E. Drew, Ohio State University College of Medicine, USA
Short Talk: Potent Antiprotozoal Activity of a Novel Semi-Synthetic Berberine Derivative


Tuesday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney Ballroom F


Tuesday, January 17 | 7:30PM - 10:00PM
Poster Session 2
Room: Sweeney Ballroom F


Wednesday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney Ballroom F


Wednesday, January 18 | 8:00AM - 11:15AM
Cell Circuitry and Adaptive Responses
Room: Sweeney Ballroom C-E

Speaker 1 of 6
Alexander D. Johnson, University of California, San Francisco, USA
Evolution of Gene Regulation in Fungi

Wednesday, January 18 | 8:00AM - 11:15AM
Cell Circuitry and Adaptive Responses
Room: Sweeney Ballroom C-E

Speaker 2 of 6
Aaron P. Mitchell, Carnegie Mellon University, USA
Portrait of Candida albicans Adherence Regulators

Wednesday, January 18 | 8:00AM - 11:15AM
Cell Circuitry and Adaptive Responses
Room: Sweeney Ballroom C-E

Speaker 3 of 6
Hiten D. Madhani, University of California, San Francisco, USA
Using a Gene Deletion Collection to Understand how Cryptococcus neoformans Causes Disease and Responds to Chemicals

Wednesday, January 18 | 8:00AM - 11:15AM
Cell Circuitry and Adaptive Responses
Room: Sweeney Ballroom C-E

Speaker 4 of 6
Maurizio Del Poeta, Medical University of South Carolina, USA
Short Talk: Identification of New Compounds Targeting the Fungal Sphingolipid Pathway

Wednesday, January 18 | 8:00AM - 11:15AM
Cell Circuitry and Adaptive Responses
Room: Sweeney Ballroom C-E

Speaker 5 of 6
* Tamara L. Doering, Washington University Medical School, USA
Short Talk: Toward an Integrated Model of Capsule Regulation in Cryptococcus neoformans

Wednesday, January 18 | 8:00AM - 11:15AM
Cell Circuitry and Adaptive Responses
Room: Sweeney Ballroom C-E

Speaker 6 of 6
Anita Sil, University of California, San Francisco, USA
Regulation of Histoplasma Cell Shape and Virulence by Temperature

Wednesday, January 18 | 8:00AM - 11:00AM
Pre-Clinical Development
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 1 of 6
* Thierry T. Diagana, Novartis Institute for Tropical Diseases, USA


Wednesday, January 18 | 8:00AM - 11:00AM
Pre-Clinical Development
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 2 of 6
Susan A. Charman, Monash University, Australia
Genesis of OZ439: From Preclinical Studies to Clinical Trials


Wednesday, January 18 | 8:00AM - 11:00AM
Pre-Clinical Development
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 3 of 6
Julio A. Urbina, Venezuelan Institute for Science Research, USA
Ergosterol Biosynthesis Inhibitors for the Specific Treatment of Chagas Disease: From Basic Science to Clinical Trials


Wednesday, January 18 | 8:00AM - 11:00AM
Pre-Clinical Development
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 4 of 6
Michael Zhuo Wang, University of Kansas, USA
Evaluation of Novel Anti-Trypanosomal Benzofuran Derivatives: Pharmacokinetics, Toxicity, and Efficacy


Wednesday, January 18 | 8:00AM - 11:00AM
Pre-Clinical Development
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 5 of 6
Rosa M. Andrade, University of California, San Diego, USA
Short Talk: A Reprofiled Drug, Auranofin, Targets the Thioredoxin Reductase of Entamoeba histolytica and is Cysticidal


Wednesday, January 18 | 8:00AM - 11:00AM
Pre-Clinical Development
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 6 of 6
Maria Jose Lafuente, GlaxoSmithKline, Spain
Short Talk: Open Source to Drug Discovery for Malaria: Sharing TCAMS


Wednesday, January 18 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney Ballroom F


Wednesday, January 18 | 11:15AM - 12:15PM
Workshop 3: Fungal Genome Databases
Room: Sweeney Ballroom C-E

Speaker 1 of 1
* Jason E. Stajich, University of California, Riverside, USA

Wednesday, January 18 | 11:15AM - 1:00PM
Poster Setup
Room: Sweeney Ballroom F


Wednesday, January 18 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, January 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney Ballroom F


Wednesday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom F


Wednesday, January 18 | 5:00PM - 7:00PM
Population Genetics and Genomics of Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Fred S. Dietrich, Duke University, USA

Wednesday, January 18 | 5:00PM - 7:00PM
Population Genetics and Genomics of Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Matthew C. Fisher, Imperial College, London, UK
Why Fungi Cause Species Extinctions: Evolutionary Insights from Population Genetics and Genomics

Wednesday, January 18 | 5:00PM - 7:00PM
Population Genetics and Genomics of Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Timothy Y. James, University of Michigan, USA
Pathogen Recombination during the Amphibian Chytridiomycosis Pandemic - Why Change What's Working?

Wednesday, January 18 | 5:00PM - 7:00PM
Population Genetics and Genomics of Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Geraldine Butler, University College Dublin, Ireland
Beyond the Candida albicans Paradigm: Evolution of the Hypoxic Response in Fungal Species

Wednesday, January 18 | 5:00PM - 7:00PM
Population Genetics and Genomics of Fungal Pathogens
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Guilhem Janbon, Institut Pasteur, France
Short Talk: Regulation of Gene Expression by Intron in Cryptococcus Neoformans

Wednesday, January 18 | 5:00PM - 7:00PM
Lead Optimization
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Susan A. Charman, Monash University, Australia


Wednesday, January 18 | 5:00PM - 7:00PM
Lead Optimization
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 2 of 5
Meg Phillips, University of Texas Southwestern Medical Center, USA
Targeting Malaria Dihydroorotate Dehydrogenase


Wednesday, January 18 | 5:00PM - 7:00PM
Lead Optimization
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 3 of 5
Geoffrey S. Dow, United States Army Medical & Material Development Activity, USA
Lead Optimization and Development of Next Generation Quinoline Methanols for Malaria Treatment and Prevention


Wednesday, January 18 | 5:00PM - 7:00PM
Lead Optimization
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Paul G. Wyatt, University of Dundee, UK
Validation of N-Myristoyltransferase as a Drug Target


Wednesday, January 18 | 5:00PM - 7:00PM
Lead Optimization
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 5 of 5
Michael P. Pollastri, Northeastern University, USA
Short Talk: Optimization of a Human Aurora Kinase Inhibitor Chemotype for Selective Anti-Trypanosomal Activity


Wednesday, January 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney Ballroom F


Wednesday, January 18 | 7:30PM - 10:00PM
Poster Session 3
Room: Sweeney Ballroom F


Thursday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney Ballroom F


Thursday, January 19 | 8:00AM - 11:15AM
Drug Resistance II/Antifungal Strategies and Resistance Mech
anisms (Joint)

Room: Sweeney Ballroom A-E

Speaker 1 of 8
* Michael T. Ferdig, University of Notre Dame, USA

Thursday, January 19 | 8:00AM - 11:15AM
Drug Resistance II/Antifungal Strategies and Resistance Mech
anisms (Joint)

Room: Sweeney Ballroom A-E

Speaker 2 of 8
* Mitchell Mutz, Roche Venture Fund, USA

Thursday, January 19 | 8:00AM - 11:15AM
Drug Resistance II/Antifungal Strategies and Resistance Mech
anisms (Joint)

Room: Sweeney Ballroom A-E

Speaker 3 of 8
Judith G. Berman, University of Minnesota, USA
Aneuploidy and Drug Resistance in Pathogenic Fungi

Thursday, January 19 | 8:00AM - 11:15AM
Drug Resistance II/Antifungal Strategies and Resistance Mech
anisms (Joint)

Room: Sweeney Ballroom A-E

Speaker 4 of 8
Pradipsinh K. Rathod, University of Washington, USA
Accelerated Acquisition of Drug Resistance in Malaria: The Problem and a Possible New Solution

Thursday, January 19 | 8:00AM - 11:15AM
Drug Resistance II/Antifungal Strategies and Resistance Mech
anisms (Joint)

Room: Sweeney Ballroom A-E

Speaker 5 of 8
Thomas E. Wellems, NIAID, National Institutes of Health, USA
Drug-Resistant Malaria: Determinants of Treatment Outcome and Prospects for Control

Thursday, January 19 | 8:00AM - 11:15AM
Drug Resistance II/Antifungal Strategies and Resistance Mech
anisms (Joint)

Room: Sweeney Ballroom A-E

Speaker 6 of 8
Geoffrey H. Siwo, University of Notre Dame, USA
Short Talk: Rewired Gene Networks Predict Differential Chemosensitivities of Multi-Drug Resistant Malaria Parasites

Thursday, January 19 | 8:00AM - 11:15AM
Drug Resistance II/Antifungal Strategies and Resistance Mech
anisms (Joint)

Room: Sweeney Ballroom A-E

Speaker 7 of 8
Damian Krysan, University of Rochester, USA
Short Talk: Protein Kinase Inhibitors as Antifungal Molecules: HTS Identification, Evaluation and Mechanism of Action

Thursday, January 19 | 8:00AM - 11:15AM
Drug Resistance II/Antifungal Strategies and Resistance Mech
anisms (Joint)

Room: Sweeney Ballroom A-E

Speaker 8 of 8
Bruce Klein, University of Wisconsin-Madison, USA
Fungi Subvert Vaccine T-Cell Priming at the Respiratory Mucosa by Inducing MMP2 and Retarding CCL7-Mediated Influx of Inflammatory Monocytes

Thursday, January 19 | 9:00AM - 9:20AM
Coffee Break
Room: Sweeney Ballroom F


Thursday, January 19 | 11:15AM - 12:15PM
Workshop 4: Career Development
Room: Sweeney Ballroom A-E


Thursday, January 19 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, January 19 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom F


Thursday, January 19 | 5:00PM - 7:00PM
Sex, Cell Identity and Virulence
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Haoping Liu, University of California, Irvine, USA

Thursday, January 19 | 5:00PM - 7:00PM
Sex, Cell Identity and Virulence
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Richard Bennett, Brown University, USA
Phenotypic Switching and Sexual Reproduction in Candida Species

Thursday, January 19 | 5:00PM - 7:00PM
Sex, Cell Identity and Virulence
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Paul Dyer, University of Nottingham, UK
Cryptic Sex in Aspergillus

Thursday, January 19 | 5:00PM - 7:00PM
Sex, Cell Identity and Virulence
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Christina M. Hull, University of Wisconsin, Madison, USA
When Sex is Hazardous to Your Health: Pathogenesis of Cryptococcus Spores


Thursday, January 19 | 5:00PM - 7:00PM
Sex, Cell Identity and Virulence
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Xiaorong Lin, Texas A&M University, USA
Short Talk: A Link in Disguise: Sex-Independent Fungal Morphogenesis and Virulence

Thursday, January 19 | 5:00PM - 7:00PM
Clinical Development
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Vicky M. Avery, Griffith University, Australia


Thursday, January 19 | 5:00PM - 7:00PM
Clinical Development
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 2 of 5
J. Kevin Baird, Eijkman Institute for Molecular Biology, Indonesia
Severe Morbidity and Mortality in Vivax Malaria and Chemotherapeutics Challenges in Coping with that Threat


Thursday, January 19 | 5:00PM - 7:00PM
Clinical Development
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 3 of 5
Anjan Debnath, University of California, San Francisco, USA
Short Talk: Drug Discovery for Naegleria


Thursday, January 19 | 5:00PM - 7:00PM
Clinical Development
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Alison Webster, GlaxoSmithKline, UK
Tafenoquine: Lessons Learned


Thursday, January 19 | 5:00PM - 7:00PM
Clinical Development
This session is from Protozoan Parasites
Room: Sweeney Ballroom A-B

Speaker 5 of 5
Thierry T. Diagana, Novartis Institute for Tropical Diseases, USA
Discovery and Development of Novel Antimalarial Drugs for the Treatment of P. falciparum and P. vivax Malaria


Thursday, January 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney Ballroom F


Thursday, January 19 | 8:00PM - 11:00PM
Entertainment
Room: Sweeney Ballroom F


Thursday, January 19 | 8:00PM - 11:00PM
Cash Bar
Room: Sweeney Ballroom F


Friday, January 20 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.