Sunday, January 22 | 3:00PM - 7:30PM

Sunday, January 22 | 7:15PM - 8:30PM

Welcome and Keynote Address (Joint)
Room: Longs/Grays Peaks

Speaker 1 of 3
* Ian A. Wilson, The Scripps Research Institute, USA

Sunday, January 22 | 7:15PM - 8:30PM

Welcome and Keynote Address (Joint)
Room: Longs/Grays Peaks

Speaker 3 of 3
Wayne A. Hendrickson, Columbia University, USA
Looking into the Future of Structure Biology: Next-Generation Synchrotrons and Applications for Biology

Monday, January 23 | 8:00AM - 11:15AM

Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 1 of 6
* Wayne A. Hendrickson, Columbia University, USA

Monday, January 23 | 8:00AM - 11:15AM

Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 3 of 6
Brian K. Shoichet, University of California, San Francisco, USA
Chemical Networks in Pharmacology

Monday, January 23 | 8:00AM - 11:15AM

Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 5 of 6
Wah Chiu, Baylor College of Medicine, USA
Cryo-Electron Microscopy and Tomography of Viruses and Infected Cells

Monday, January 23 | 9:30AM - 9:50AM

Monday, January 23 | 11:15AM - 11:15AM

Monday, January 23 | 2:15PM - 4:30PM

Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 1 of 10
* Andrej Sali, University of California, San Francisco, USA

Monday, January 23 | 2:15PM - 4:30PM

Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 3 of 10
Franz Herzog, Gene Center Munich, Germany
Probing the Topology of Endogenous Human Protein Complexes by Chemical Cross-Linking and Mass Spectrometry

Monday, January 23 | 2:15PM - 4:30PM

Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 5 of 10
John A. Tainer, The Scripps Research Institute, USA
Efficient Computational Assessments for Accurate Mass, Models and Resolution in Small-Angle Scattering Analyses

Monday, January 23 | 2:15PM - 4:30PM

Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 7 of 10
Gregory L. Warren, OpenEye Scientific Software Inc., USA
Automatic Ligand Conformer, Placement and Refinement Dictionary Generation Using Afitt

Monday, January 23 | 2:15PM - 4:30PM

Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 9 of 10
David Hargreaves, AstraZeneca, UK
A Manual, Low-Cost Protein-Crystallisation Plate jig for in-situ Diffraction in the Home Laboratory

Monday, January 23 | 4:30PM - 5:00PM

Monday, January 23 | 5:00PM - 7:00PM

Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination

Room: Shavano

Speaker 2 of 6
Imre Berger, EMBL Grenoble, France
Complexomics: New Tools and Strategies for Producing Eukaryotic Multiprotein Assemblies

Monday, January 23 | 5:00PM - 7:00PM

Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination

Room: Shavano

Speaker 4 of 6
Christopher G. Tate, MRC Laboratory of Molecular Biology, UK
Conformational Thermostabilization and Engineering of Integral Membrane Proteins for Structural Studies

Monday, January 23 | 5:00PM - 7:00PM

Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination

Room: Shavano

Speaker 6 of 6
José Antonio Márquez, European Molecular Biology Laboratory (EMBL), France
Short Talk: Crystal Direct : A New System for Automated Crystal Harvesting.

Monday, January 23 | 5:00PM - 7:15PM

Monday, January 23 | 5:00PM - 7:15PM

Monday, January 23 | 5:00PM - 7:15PM

Monday, January 23 | 7:30PM - 10:00PM

Tuesday, January 24 | 8:00AM - 11:15AM

Advances in Computational and Hybrid Approaches to Structure
Determination

Room: Shavano

Speaker 1 of 7
* Carol V. Robinson, University of Oxford, UK

Tuesday, January 24 | 8:00AM - 11:15AM

Advances in Computational and Hybrid Approaches to Structure
Determination

Room: Shavano

Speaker 3 of 7
David Baker, University of Washington, USA
Structure Determination using Sparse Experimental Data

Tuesday, January 24 | 8:00AM - 11:15AM

Advances in Computational and Hybrid Approaches to Structure
Determination

Room: Shavano

Speaker 5 of 7
Andrej Sali, University of California, San Francisco, USA
Integrative Structure Determination

Tuesday, January 24 | 8:00AM - 11:15AM

Advances in Computational and Hybrid Approaches to Structure
Determination

Room: Shavano

Speaker 7 of 7
Torsten Schwede, Biozentrum University of Basel & Swiss Institute of Bioinformatics, Switzerland
Short Talk: CAMEO - Continuous Automated Evaluation of Protein Structure Prediction Servers

Tuesday, January 24 | 8:00AM - 11:00AM

Tuesday, January 24 | 8:00AM - 11:00AM

Tuesday, January 24 | 9:20AM - 9:40AM

Tuesday, January 24 | 11:15AM - 11:15AM

Tuesday, January 24 | 2:15PM - 4:30PM

Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 1 of 10
* Cheryl Arrowsmith, University of Toronto, Canada

Tuesday, January 24 | 2:15PM - 4:30PM

Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 3 of 10
Susanne Gräslund, University of Toronto, Canada
A Pipeline to Generate Recombinant Monoclonal Antibodies to Human Target Proteins Linked to Epigenetic Mechanisms

Tuesday, January 24 | 2:15PM - 4:30PM

Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 5 of 10
Dušan Turk, Jozef Stefan Institute, Slovenia
Studies of Endosomal Proteins Involved in Immune Response and Their Targets from Human Pathogens

Tuesday, January 24 | 2:15PM - 4:30PM

Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 7 of 10
Gaetano Thomas Montelione, Rutgers University, USA
Critical Assessment of Automated Protein Structure Determination by NMR

Tuesday, January 24 | 2:15PM - 4:30PM

Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 9 of 10
Juri Rappsilber, Wellcome Trust Centre, University of Edinburgh, UK
Structural Biology by Mass Spectrometry: 3D Proteomics of Supramolecular Assemblies

Tuesday, January 24 | 4:30PM - 5:00PM

Tuesday, January 24 | 5:00PM - 7:05PM

Tuesday, January 24 | 5:00PM - 7:05PM

Tuesday, January 24 | 5:00PM - 7:05PM

Tuesday, January 24 | 5:25PM - 7:15PM

Advances in Membrane Proteins
Room: Shavano

Speaker 2 of 6
Robert M. Stroud, University of California, San Francisco, USA
Structures of Membrane Proteins and Multimeric Membrane Protein Complexes

Tuesday, January 24 | 5:25PM - 7:15PM

Advances in Membrane Proteins
Room: Shavano

Speaker 4 of 6
Raymond Stevens, ShanghaiTech University and University of Southern California, USA
Understanding G-protein Coupled Receptor Molecular Recognition and Structural Diversity

Tuesday, January 24 | 5:25PM - 7:15PM

Advances in Membrane Proteins
Room: Shavano

Speaker 6 of 6
Petra Fromme, Arizona State University, USA
Short talk: Femtosecond Nanocrystallography of Membrane Proteins

Tuesday, January 24 | 7:30PM - 10:00PM

Wednesday, January 25 | 8:00AM - 11:30AM

Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 1 of 7
* Wah Chiu, Baylor College of Medicine, USA

Wednesday, January 25 | 8:00AM - 11:30AM

Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 3 of 7
Carol V. Robinson, University of Oxford, UK
The Flight of Intact V-Type ATPases Provides a New Phase for Exploring Subunit Interactions and the Functional Role of Nucleotide and Lipid Binding

Wednesday, January 25 | 8:00AM - 11:30AM

Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 5 of 7
Lewis E. Kay, University of Toronto, Canada
Seeing the Invisible by Solution - NMR Spectroscopy

Wednesday, January 25 | 8:00AM - 11:30AM

Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 7 of 7
Barry Honig, Columbia University / HHMI, USA
Toward the Integration of Structural and Systems Biology: Structure-Based Prediction of Protein-Protein Interactions on a Genome-Wide Scale

Wednesday, January 25 | 11:15AM - 11:15AM

Wednesday, January 25 | 4:30PM - 6:30PM

Novel Approaches to Decipher Function from Structure
Room: Shavano

Speaker 1 of 5
* Gaetano Thomas Montelione, Rutgers University, USA

Wednesday, January 25 | 4:30PM - 6:30PM

Novel Approaches to Decipher Function from Structure
Room: Shavano

Speaker 3 of 5
John A. Gerlt, University of Illinois at Urbana-Champaign, USA
Discovering and Predicting New Functions in the Enolase Superfamily

Wednesday, January 25 | 4:30PM - 6:30PM

Novel Approaches to Decipher Function from Structure
Room: Shavano

Speaker 5 of 5
William A. McLaughlin, Commonwealth Medical College, USA
Short Talk: KB-Role: An Online Resource for the Identification of Predicted Protein Functions and their Associated Probabilities

Wednesday, January 25 | 4:30PM - 6:10PM

Wednesday, January 25 | 4:30PM - 6:10PM

Wednesday, January 25 | 6:30PM - 7:30PM

Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 1 of 10
* Ian A. Wilson, The Scripps Research Institute, USA

Wednesday, January 25 | 6:30PM - 7:30PM

Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 3 of 10
Gregory A. Petsko, Brandeis University, USA

Wednesday, January 25 | 6:30PM - 7:30PM

Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 5 of 10
Anna Marie Pyle, Yale University, USA

Wednesday, January 25 | 6:30PM - 7:30PM

Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 7 of 10
Robert M. Stroud, University of California, San Francisco, USA

Wednesday, January 25 | 6:30PM - 7:30PM

Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 9 of 10
Brian K. Kobilka, Stanford University School of Medicine, USA

Wednesday, January 25 | 7:15PM - 8:15PM

Thursday, January 26 | 7:00AM - 8:00AM

Thursday, January 26 | 8:00AM - 11:25AM

High-Throughput Structural Biology Applied to Biological Sys
tems

Room: Shavano

Speaker 2 of 7
Udo Oppermann, University of Oxford, UK
Targeting the Histone Demethylome

Thursday, January 26 | 8:00AM - 11:25AM

High-Throughput Structural Biology Applied to Biological Sys
tems

Room: Shavano

Speaker 4 of 7
James R. Williamson, The Scripps Research Institute, USA
Short Talk: Structural Genomics of Ribonucleoprotein Complexes Involved in T-Cell Activation

Thursday, January 26 | 8:00AM - 11:25AM

High-Throughput Structural Biology Applied to Biological Sys
tems

Room: Shavano

Speaker 6 of 7
Ian A. Wilson, The Scripps Research Institute, USA
Exploration of the Human Gut Microbiome

Thursday, January 26 | 8:00AM - 11:15AM

Thursday, January 26 | 8:00AM - 11:15AM

Thursday, January 26 | 8:00AM - 11:15AM

Thursday, January 26 | 8:00AM - 11:15AM

Thursday, January 26 | 10:00AM - 10:00AM

Thursday, January 26 | 4:30PM - 6:15PM

From Drug Targets to High-Throughput Structural Biology to t
he Clinic

Room: Grays Peak

Speaker 1 of 5
* Brian K. Shoichet, University of California, San Francisco, USA

Thursday, January 26 | 4:30PM - 6:15PM

From Drug Targets to High-Throughput Structural Biology to t
he Clinic

Room: Grays Peak

Speaker 3 of 5
Aled M. Edwards, University of Toronto, Canada
Structural Genomics and Drug Discovery

Thursday, January 26 | 4:30PM - 6:15PM

From Drug Targets to High-Throughput Structural Biology to t
he Clinic

Room: Grays Peak

Speaker 5 of 5
Anna Maria Tochowicz, Amgen, USA
Short Talk: New Drug Leads for Chagas’ Disease Identified by Fragment Chemistry and Structural Analysis

Thursday, January 26 | 4:30PM - 6:15PM

Thursday, January 26 | 4:30PM - 6:15PM

Thursday, January 26 | 6:15PM - 7:15PM

Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 2 of 9
Brian K. Shoichet, University of California, San Francisco, USA

Thursday, January 26 | 6:15PM - 7:15PM

Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 4 of 9
Margaret J. Gabanyi, PSI Structural Biology Knowledgebase - Rutgers University, USA

Thursday, January 26 | 6:15PM - 7:15PM

Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 6 of 9
Michael G. Rossmann, Purdue University, USA

Thursday, January 26 | 6:15PM - 7:15PM

Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 8 of 9
Adam Godzik, Sanford-Burnham Medical Research Institute, USA

Thursday, January 26 | 7:15PM - 8:15PM

Thursday, January 26 | 8:30PM - 11:00PM