Web Desc
High-Throughput Structural Biology
joint with Structural Biology of Cellular Processes: From Atoms to Cells
Organizer(s): Ian A. Wilson, Aled M. Edwards, Tracy M. Handel and Andrej Sali
Date: January 22 - 27, 2012
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Bayer USA Foundation
Summary of Meeting:
Structural biology continues to be one of the most prolific and informative ways to make biological and biomedical discoveries, and provides fundamental molecular insights into biological systems. The rapidly expanding numbers of sequenced genomes is providing structural biologists with a wealth of new opportunities and challenges to explore the enormous diversity of biological macromolecules and their relationships to function, evolution and disease. The goal of this meeting is to explore current advances and frontiers in structural biology and illustrate how high-throughput approaches in X-Ray Crystallography and NMR – in combination with hybrid methods using computational and other biophysical techniques (including CryoEM, Xray and Electron Tomography, SAXS, Mass Spectometry, Proteomics) – can be used to tackle topical and challenging problems in molecular, cellular and chemical biology. This symposium will focus on the variety of approaches and methodologies that are available to both structural biologists and biologists for investigation of biological systems and their component macromolecules and complexes. Two open debates will address topical issues of great relevance to the field. The attendees will also have an opportunity to broaden their appreciation of the complex biological systems that can benefit from these current advances in structural biology via the sister meeting on Structural Biology of Cellular Processes: From Atoms to Cells, which will share a keynote address and two plenary sessions with this meeting.
Scholarship Deadline: September 22 2011
Discounted Abstract Deadline: September 22 2011
Abstract Deadline: October 25 2011
Discounted Registration Deadline: November 22 2011
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer USA Foundation
We gratefully acknowledge additional support for this conference from:
Agilent TechnologiesBruker BioSpin Corp.Chroma Technology CorporationGenScript USA Inc.ISOTEC, a member of the Sigma-Aldrich Group
Rigaku Americas Corporation
Takeda California


Robert Griffin
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM099331-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 22 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, January 22 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Sunday, January 22 | 7:15PM - 8:30PM
Welcome and Keynote Address (Joint)
Room: Longs/Grays Peaks

Speaker 1 of 3
* Ian A. Wilson, The Scripps Research Institute, USA

Sunday, January 22 | 7:15PM - 8:30PM
Welcome and Keynote Address (Joint)
Room: Longs/Grays Peaks

Speaker 2 of 3
* Steven C. Almo, Albert Einstein College of Medicine, USA

Sunday, January 22 | 7:15PM - 8:30PM
Welcome and Keynote Address (Joint)
Room: Longs/Grays Peaks

Speaker 3 of 3
Wayne A. Hendrickson, Columbia University, USA
Looking into the Future of Structure Biology: Next-Generation Synchrotrons and Applications for Biology

Monday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Monday, January 23 | 8:00AM - 11:15AM
Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 1 of 6
* Wayne A. Hendrickson, Columbia University, USA

Monday, January 23 | 8:00AM - 11:15AM
Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 2 of 6
Bo Huang, University of California, San Francisco, USA
Molecular Complexes under the Light Microscope

Monday, January 23 | 8:00AM - 11:15AM
Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 3 of 6
Brian K. Shoichet, University of California, San Francisco, USA
Chemical Networks in Pharmacology

Monday, January 23 | 8:00AM - 11:15AM
Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 4 of 6
Kurt Wüthrich, ETH Zürich, Switzerland
Solution NMR Studies of GPCR Structure and Function

Monday, January 23 | 8:00AM - 11:15AM
Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 5 of 6
Wah Chiu, Baylor College of Medicine, USA
Cryo-Electron Microscopy and Tomography of Viruses and Infected Cells

Monday, January 23 | 8:00AM - 11:15AM
Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 6 of 6
Graham T. Johnson, University of California, San Francisco, USA
Short Talk: Applications of Mesoscale Modeling and Visualization Software

Monday, January 23 | 9:30AM - 9:50AM
Coffee Break
Room: Longs Peak Foyer


Monday, January 23 | 11:15AM - 1:00PM
Poster Setup
Room: Grays


Monday, January 23 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, January 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays


Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 1 of 10
* Andrej Sali, University of California, San Francisco, USA

Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 2 of 10
Martin Beck, European Molecular Biology Laboratory, Germany
Investigating Human Nuclear Pore Composition by Targeted Mass Spectrometry

Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 3 of 10
Franz Herzog, Gene Center Munich, Germany
Probing the Topology of Endogenous Human Protein Complexes by Chemical Cross-Linking and Mass Spectrometry

Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 4 of 10
Nikolaos G. Sgourakis, University of California, Santa Cruz, USA
Advances in Structure Determination of Monomeric Proteins and Protein Complexes using Sparse NMR Data

Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 5 of 10
John A. Tainer, The Scripps Research Institute, USA
Efficient Computational Assessments for Accurate Mass, Models and Resolution in Small-Angle Scattering Analyses

Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 6 of 10
Charles H. Greenberg, University of California, San Francisco, USA
Threading a Protein Sequence onto its CryoEM Density Map

Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 7 of 10
Gregory L. Warren, OpenEye Scientific Software Inc., USA
Automatic Ligand Conformer, Placement and Refinement Dictionary Generation Using Afitt

Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 8 of 10
Ezgi Karaca, Utrecht University, Netherlands
A Flexible Multi-Domain Docking Approach to Deal with Large Conformational Changes in the Modeling of Biomolecular Complexes

Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 9 of 10
David Hargreaves, AstraZeneca, UK
A Manual, Low-Cost Protein-Crystallisation Plate jig for in-situ Diffraction in the Home Laboratory

Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Shavano

Speaker 10 of 10
M.Y. Heidari Khajehpour, Institut de Biologie Structurale, France
G-Rob with Crystal Listing Function for a New High Throughput in situ X-Ray Diffraction

Monday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 23 | 5:00PM - 7:00PM
Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination

Room: Shavano

Speaker 1 of 6
* Andrzej Joachimiak, Argonne National Laboratory, USA

Monday, January 23 | 5:00PM - 7:00PM
Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination

Room: Shavano

Speaker 2 of 6
Imre Berger, EMBL Grenoble, France
Complexomics: New Tools and Strategies for Producing Eukaryotic Multiprotein Assemblies

Monday, January 23 | 5:00PM - 7:00PM
Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination

Room: Shavano

Speaker 3 of 6
Shohei Koide, New York University Langone Health, USA
Designer Binding Proteins for Controlling Biology

Monday, January 23 | 5:00PM - 7:00PM
Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination

Room: Shavano

Speaker 4 of 6
Christopher G. Tate, MRC Laboratory of Molecular Biology, UK
Conformational Thermostabilization and Engineering of Integral Membrane Proteins for Structural Studies

Monday, January 23 | 5:00PM - 7:00PM
Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination

Room: Shavano

Speaker 5 of 6
Shin-ichi Makino, University of Wisconson, Madison / CESG, USA
Short Talk: Strategies for Membrane Protein Preparation at the Transmembrane Protein Center Utilizing Cell-Free and Cell-based Systems

Monday, January 23 | 5:00PM - 7:00PM
Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination

Room: Shavano

Speaker 6 of 6
José Antonio Márquez, European Molecular Biology Laboratory (EMBL), France
Short Talk: Crystal Direct : A New System for Automated Crystal Harvesting.

Monday, January 23 | 5:00PM - 7:15PM
Neurodegenerative and Misfolding Diseases
This session is from Structural Biology
Room: Red Cloud

Speaker 1 of 6
* Kurt Wüthrich, ETH Zürich, Switzerland


Monday, January 23 | 5:00PM - 7:15PM
Neurodegenerative and Misfolding Diseases
This session is from Structural Biology
Room: Red Cloud

Speaker 2 of 6
Gregory A. Petsko, Brandeis University, USA
Structural and Genetic Basis of Neurodegenerative Diseases


Monday, January 23 | 5:00PM - 7:15PM
Neurodegenerative and Misfolding Diseases
This session is from Structural Biology
Room: Red Cloud

Speaker 3 of 6
Raquel L. Lieberman, Georgia Institute of Technology, USA
Structural and Biophysical Insights into the Olfactomedin Domain of Myocilin: Implications for Glaucoma


Monday, January 23 | 5:00PM - 7:15PM
Neurodegenerative and Misfolding Diseases
This session is from Structural Biology
Room: Red Cloud

Speaker 4 of 6
Robert G. Griffin, Massachusetts Institute of Technology, USA
Atomic Resolution Structures of Amyloid Fibrils


Monday, January 23 | 5:00PM - 7:15PM
Neurodegenerative and Misfolding Diseases
This session is from Structural Biology
Room: Red Cloud

Speaker 5 of 6
Andy Baldwin, University of Toronto, Canada
Short Talk: NMR Spectroscopy, Mass Spectrometry and Electron Microscopy Elucidate the Structure and Dynamics of alphaB-Crystallin Oligomers


Monday, January 23 | 5:00PM - 7:15PM
Neurodegenerative and Misfolding Diseases
This session is from Structural Biology
Room: Red Cloud

Speaker 6 of 6
David E. Timm, Eli Lilly and Company, USA
Short Talk: Fragment-Based Design and Clinical Translation of BACE Inhibitors


Monday, January 23 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grays


Monday, January 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Grays


Tuesday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination

Room: Shavano

Speaker 1 of 7
* Carol V. Robinson, University of Oxford, UK

Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination

Room: Shavano

Speaker 2 of 7
Michael G. Rossmann, Purdue University, USA
Electron Microscopy, X-Ray Crystallography and Molecular Modeling for Structural Determination

Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination

Room: Shavano

Speaker 3 of 7
David Baker, University of Washington, USA
Structure Determination using Sparse Experimental Data

Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination

Room: Shavano

Speaker 4 of 7
Jianpeng Ma, Baylor College of Medicine, USA
Normal-Mode Refinement of Highly-Mobile X-Ray Structures at Lower Resolutions

Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination

Room: Shavano

Speaker 5 of 7
Andrej Sali, University of California, San Francisco, USA
Integrative Structure Determination

Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination

Room: Shavano

Speaker 6 of 7
Debora Marks, Harvard Medical School, USA
Short Talk: 3D Protein Structure Predicted de novo from Evolutionary Sequence Variation

Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination

Room: Shavano

Speaker 7 of 7
Torsten Schwede, Biozentrum University of Basel & Swiss Institute of Bioinformatics, Switzerland
Short Talk: CAMEO - Continuous Automated Evaluation of Protein Structure Prediction Servers

Tuesday, January 24 | 8:00AM - 11:00AM
Dynamical Machines in RNA Metabolism
This session is from Structural Biology
Room: Red Cloud

Speaker 1 of 5
Leemor Joshua-Tor, HHMI/Cold Spring Harbor Laboratory, USA
Coupling RNAi to Heterochromatin: Insights into the Structural Core of the RITS Complex


Tuesday, January 24 | 8:00AM - 11:00AM
Dynamical Machines in RNA Metabolism
This session is from Structural Biology
Room: Red Cloud

Speaker 2 of 5
* Anna Marie Pyle, Yale University, USA
Determinants of Splicing


Tuesday, January 24 | 8:00AM - 11:00AM
Dynamical Machines in RNA Metabolism
This session is from Structural Biology
Room: Red Cloud

Speaker 3 of 5
Holger Stark, Max Planck Institute for Biophysical Chemistry, Germany
Biochemical Stabilization and 3D Structure Determination of Dynamic Macromolecular Complexes


Tuesday, January 24 | 8:00AM - 11:00AM
Dynamical Machines in RNA Metabolism
This session is from Structural Biology
Room: Red Cloud

Speaker 4 of 5
Alfonso Mondragón, Northwestern University, USA
Structure and Mechanism of Bacterial RNase P


Tuesday, January 24 | 8:00AM - 11:00AM
Dynamical Machines in RNA Metabolism
This session is from Structural Biology
Room: Red Cloud

Speaker 5 of 5
John P. Marino, National Institute of Standards and Technology, USA
Short Talk: Structural Determinants of the Dimerization and Maturation of the HIV-1 Genomic RNA Dimerization Initiation Site


Tuesday, January 24 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, January 24 | 11:15AM - 1:00PM
Poster Setup
Room: Grays


Tuesday, January 24 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, January 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays


Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 1 of 10
* Cheryl Arrowsmith, University of Toronto, Canada

Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 2 of 10
Andrew B. Ward, The Scripps Research Institute, USA
Using Electron Microscopy to Rapidly Characterize the Interaction of Neutralizing Antibodies with Viral Envelope Proteins

Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 3 of 10
Susanne Gräslund, University of Toronto, Canada
A Pipeline to Generate Recombinant Monoclonal Antibodies to Human Target Proteins Linked to Epigenetic Mechanisms

Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 4 of 10
John L. Markley, University of Wisconsin-Madison, USA
PSI:Biology Mitochondrial Protein Partnership - Mission and Progress

Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 5 of 10
Dušan Turk, Jozef Stefan Institute, Slovenia
Studies of Endosomal Proteins Involved in Immune Response and Their Targets from Human Pathogens

Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 6 of 10
Andrzej Joachimiak, Argonne National Laboratory, USA
Glycoside Hydrolases from the Human Gut Microbiome

Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 7 of 10
Gaetano Thomas Montelione, Rutgers University, USA
Critical Assessment of Automated Protein Structure Determination by NMR

Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 8 of 10
Kevin S. Keating, Yale University, USA
Semi-Automated Model Building for RNA Crystallography

Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 9 of 10
Juri Rappsilber, Wellcome Trust Centre, University of Edinburgh, UK
Structural Biology by Mass Spectrometry: 3D Proteomics of Supramolecular Assemblies

Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
Room: Shavano

Speaker 10 of 10
Margaret J. Gabanyi, PSI Structural Biology Knowledgebase - Rutgers University, USA
The PSI SBKB: A One-Stop Shop for Protein, Models, Functions, Methods and More

Tuesday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 24 | 5:00PM - 7:05PM
Cytoskeletal Organization and Function
This session is from Structural Biology
Room: Red Cloud

Speaker 1 of 6
* Michael K. Rosen, University of Texas Southwestern Medical Center, USA


Tuesday, January 24 | 5:00PM - 7:05PM
Cytoskeletal Organization and Function
This session is from Structural Biology
Room: Red Cloud

Speaker 2 of 6
Neil Q. McDonald, Cancer Research UK, UK
Molecular Analysis of a G-Actin Sensor


Tuesday, January 24 | 5:00PM - 7:05PM
Cytoskeletal Organization and Function
This session is from Structural Biology
Room: Red Cloud

Speaker 3 of 6
Ohad Medalia, Zurich University, Switzerland
Structural Study on Cell Adhesion by Cryo-Electron Tomography


Tuesday, January 24 | 5:00PM - 7:05PM
Cytoskeletal Organization and Function
This session is from Structural Biology
Room: Red Cloud

Speaker 4 of 6
Anne Houdusse, Institut Curie, France
How Myosin Motors Powers Cellular Functions: New Insights from Coupling Structural and Functional Insights


Tuesday, January 24 | 5:00PM - 7:05PM
Cytoskeletal Organization and Function
This session is from Structural Biology
Room: Red Cloud

Speaker 5 of 6
Nathaniel L. Elsen, AbbVie, Inc., USA
Short Talk: Biochemical and Structural Basis for the Abolition of S. aureus FtsZ Polymerization Cooperativity by the Cell-Division Inhibitor PC190723


Tuesday, January 24 | 5:00PM - 7:05PM
Cytoskeletal Organization and Function
This session is from Structural Biology
Room: Red Cloud


Short Talk Chosen from Abstracts


Tuesday, January 24 | 5:25PM - 7:15PM
Advances in Membrane Proteins
Room: Shavano

Speaker 1 of 6
* Andrew B. Ward, The Scripps Research Institute, USA

Tuesday, January 24 | 5:25PM - 7:15PM
Advances in Membrane Proteins
Room: Shavano

Speaker 2 of 6
Robert M. Stroud, University of California, San Francisco, USA
Structures of Membrane Proteins and Multimeric Membrane Protein Complexes

Tuesday, January 24 | 5:25PM - 7:15PM
Advances in Membrane Proteins
Room: Shavano

Speaker 3 of 6
Brian K. Kobilka, Stanford University School of Medicine, USA
Structural Insights into the Dynamic Process of G Protein Coupled Receptor Activation

Tuesday, January 24 | 5:25PM - 7:15PM
Advances in Membrane Proteins
Room: Shavano

Speaker 4 of 6
Raymond Stevens, ShanghaiTech University and University of Southern California, USA
Understanding G-protein Coupled Receptor Molecular Recognition and Structural Diversity

Tuesday, January 24 | 5:25PM - 7:15PM
Advances in Membrane Proteins
Room: Shavano

Speaker 5 of 6
Tracy M. Handel, University of California, San Diego, USA
Short Talk: Chemokine Receptors in Cell Signaling and Movement

Tuesday, January 24 | 5:25PM - 7:15PM
Advances in Membrane Proteins
Room: Shavano

Speaker 6 of 6
Petra Fromme, Arizona State University, USA
Short talk: Femtosecond Nanocrystallography of Membrane Proteins

Tuesday, January 24 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grays


Tuesday, January 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Grays


Wednesday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 1 of 7
* Wah Chiu, Baylor College of Medicine, USA

Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 2 of 7
Carolyn A. Larabell, University of California, San Francisco, USA
X-Ray Tomography of Organisms and Organelles

Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 3 of 7
Carol V. Robinson, University of Oxford, UK
The Flight of Intact V-Type ATPases Provides a New Phase for Exploring Subunit Interactions and the Functional Role of Nucleotide and Lipid Binding

Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 4 of 7
Timothy O. Street, University of California, San Francisco, USA
Short Talk: Extracting Mechanistic Information about the Hsp90 Molecular Chaperone with a Model Unfolded Protein Substrate

Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 5 of 7
Lewis E. Kay, University of Toronto, Canada
Seeing the Invisible by Solution - NMR Spectroscopy

Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 6 of 7
A. Joshua Wand, University of Pennsylvania, USA
Short Talk: Walking on Water: Enabling Site-Resolved Measurement of Hydration Dynamics with Solution NMR

Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 7 of 7
Barry Honig, Columbia University / HHMI, USA
Toward the Integration of Structural and Systems Biology: Structure-Based Prediction of Protein-Protein Interactions on a Genome-Wide Scale

Wednesday, January 25 | 9:15AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, January 25 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, January 25 | 4:00PM - 4:30PM
Coffee Available
Room: Foyer


Wednesday, January 25 | 4:30PM - 6:30PM
Novel Approaches to Decipher Function from Structure
Room: Shavano

Speaker 1 of 5
* Gaetano Thomas Montelione, Rutgers University, USA

Wednesday, January 25 | 4:30PM - 6:30PM
Novel Approaches to Decipher Function from Structure
Room: Shavano

Speaker 2 of 5
Nevan J. Krogan, University of California, San Francisco, USA
Advances in Characterization of Protein-Protein Interaction Networks

Wednesday, January 25 | 4:30PM - 6:30PM
Novel Approaches to Decipher Function from Structure
Room: Shavano

Speaker 3 of 5
John A. Gerlt, University of Illinois at Urbana-Champaign, USA
Discovering and Predicting New Functions in the Enolase Superfamily

Wednesday, January 25 | 4:30PM - 6:30PM
Novel Approaches to Decipher Function from Structure
Room: Shavano

Speaker 4 of 5
Adam Godzik, Sanford-Burnham Medical Research Institute, USA
Inferring Function from Structure and Genome Context

Wednesday, January 25 | 4:30PM - 6:30PM
Novel Approaches to Decipher Function from Structure
Room: Shavano

Speaker 5 of 5
William A. McLaughlin, Commonwealth Medical College, USA
Short Talk: KB-Role: An Online Resource for the Identification of Predicted Protein Functions and their Associated Probabilities

Wednesday, January 25 | 4:30PM - 6:10PM
Signaling and Switches
This session is from Structural Biology
Room: Red Cloud

Speaker 1 of 5
* Gregory A. Petsko, Brandeis University, USA


Wednesday, January 25 | 4:30PM - 6:10PM
Signaling and Switches
This session is from Structural Biology
Room: Red Cloud

Speaker 2 of 5
Robert T. Batey, University of Colorado, Boulder, USA
Structure and Function of Riboswitches


Wednesday, January 25 | 4:30PM - 6:10PM
Signaling and Switches
This session is from Structural Biology
Room: Red Cloud

Speaker 3 of 5
Michael K. Rosen, University of Texas Southwestern Medical Center, USA
Regulation of Actin Assembly from Angstroms to Microns


Wednesday, January 25 | 4:30PM - 6:10PM
Signaling and Switches
This session is from Structural Biology
Room: Red Cloud

Speaker 4 of 5
Mark A. Lemmon, University of Pennsylvania Perelman School of Medicine, USA
Structural Basis for Ligand Regulation of Growth Factor Receptors


Wednesday, January 25 | 4:30PM - 6:10PM
Signaling and Switches
This session is from Structural Biology
Room: Red Cloud

Speaker 5 of 5
Oliver Hantschel, Swiss Federal Institute of Technology Lausanne, Switzerland
Short Talk: Structural and Functional Analysis of the Regulation of the c-Abl and Bcr-Abl Tyrosine Kinases


Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 1 of 10
* Ian A. Wilson, The Scripps Research Institute, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 2 of 10
Aled M. Edwards, University of Toronto, Canada

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 3 of 10
Gregory A. Petsko, Brandeis University, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 4 of 10
Wayne A. Hendrickson, Columbia University, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 5 of 10
Anna Marie Pyle, Yale University, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 6 of 10
Abby F. Dernburg, University of California, Berkeley, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 7 of 10
Robert M. Stroud, University of California, San Francisco, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 8 of 10
Andrzej Joachimiak, Argonne National Laboratory, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 9 of 10
Brian K. Kobilka, Stanford University School of Medicine, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 10 of 10
James R. Williamson, The Scripps Research Institute, USA

Wednesday, January 25 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grays


Wednesday, January 25 | 7:45PM - 10:00PM
Workshop 3: Mega Poster Session on World-Wide Structural Bio
logy and Biology Center/Consortia and Large-Scale Databases and Repositories
Room: Grays
Structural biology centers and consortia highlight the platforms, new methods, technologies, databases, and computational tools that that have been developed to advance protein production and macromolecular structure determination for all classes of targets from bacterial to human and on challenging macromolecules, such as membrane proteins, eukaryotic proteins and protein complexes. Likewise, Biology centers will illustrate how they are using high throughput approaches to tackle challenging biological problems. Emphasis will be placed on what is applicable to the entire community, including single investigator laboratories to increase success and throughput in the study of biological macromolecules, complexes, and biological systems.

Thursday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems

Room: Shavano

Speaker 1 of 7
* Aled M. Edwards, University of Toronto, Canada

Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems

Room: Shavano

Speaker 2 of 7
Udo Oppermann, University of Oxford, UK
Targeting the Histone Demethylome

Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems

Room: Shavano

Speaker 3 of 7
Cheryl Arrowsmith, University of Toronto, Canada
Structural and Chemical Biology of the Readers of the Histone Code

Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems

Room: Shavano

Speaker 4 of 7
James R. Williamson, The Scripps Research Institute, USA
Short Talk: Structural Genomics of Ribonucleoprotein Complexes Involved in T-Cell Activation

Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems

Room: Shavano

Speaker 5 of 7
Steven C. Almo, Albert Einstein College of Medicine, USA
Challenges and Opportunities for High-Throughput Structural Biology of Eukaryotic Systems

Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems

Room: Shavano

Speaker 6 of 7
Ian A. Wilson, The Scripps Research Institute, USA
Exploration of the Human Gut Microbiome

Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems

Room: Shavano

Speaker 7 of 7
Lance Stewart, Institute for Protein Design at University of Washington, USA
Short Talk: SGCID: Four Hundred Protein Structures from Microbial Pathogens

Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
This session is from Structural Biology
Room: Red Cloud

Speaker 1 of 7
* Anna Marie Pyle, Yale University, USA


Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
This session is from Structural Biology
Room: Red Cloud

Speaker 2 of 7
Dylan J. Taatjes, University of Colorado Boulder, USA
Structure and Mechanism of the human Transcription Initiation Machinery


Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
This session is from Structural Biology
Room: Red Cloud

Speaker 3 of 7
Abby F. Dernburg, University of California, Berkeley, USA
Imaging Chromosome Dynamics in Living Animals: Technical Challenges and Recent Advances


Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
This session is from Structural Biology
Room: Red Cloud

Speaker 4 of 7
Antonina Roll-Mecak, DHHS/NINDS, National Institutes of Health, USA
Tales of Tubulin Tails: Insights into Tubulin Post-Translational Modifications


Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
This session is from Structural Biology
Room: Red Cloud

Speaker 5 of 7
Sheena D'Arcy, HHMI/Colorado State University, USA
Conformation and Dynamics of Histone Proteins


Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
This session is from Structural Biology
Room: Red Cloud

Speaker 6 of 7
Hal A. Lewis, Bristol-Myers Squibb, USA
Short Talk: Crystal Structure of Inhibitor-Bound H1N1 Influenza Nucleoprotein Reveals Mode of Higher-Order Oligomerization


Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
This session is from Structural Biology
Room: Red Cloud

Speaker 7 of 7
Ryan Rochat, Baylor College of Medicine, USA
Short Talk: Zernike Phase Contrast Cryo-Em Reveals the Structure of the Genome Packaging Apparatus in Herpes Simplex Virus


Thursday, January 26 | 9:15AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, January 26 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, January 26 | 4:00PM - 4:30PM
Coffee Available
Room: Foyer


Thursday, January 26 | 4:30PM - 6:15PM
From Drug Targets to High-Throughput Structural Biology to t
he Clinic

Room: Grays Peak

Speaker 1 of 5
* Brian K. Shoichet, University of California, San Francisco, USA

Thursday, January 26 | 4:30PM - 6:15PM
From Drug Targets to High-Throughput Structural Biology to t
he Clinic

Room: Grays Peak

Speaker 2 of 5
James C. Sacchettini, Texas A & M University, USA
New Approaches to Identifying Antibacterial Drug Targets and Drug Discovery

Thursday, January 26 | 4:30PM - 6:15PM
From Drug Targets to High-Throughput Structural Biology to t
he Clinic

Room: Grays Peak

Speaker 3 of 5
Aled M. Edwards, University of Toronto, Canada
Structural Genomics and Drug Discovery

Thursday, January 26 | 4:30PM - 6:15PM
From Drug Targets to High-Throughput Structural Biology to t
he Clinic

Room: Grays Peak

Speaker 4 of 5
Jonathan M. Moore, Vertex Pharmaceuticals Incorporated, USA
Short Talk: The Ectodomain Complex of the CGRP Receptor: Insights into Antagonism of a Class B GPRC

Thursday, January 26 | 4:30PM - 6:15PM
From Drug Targets to High-Throughput Structural Biology to t
he Clinic

Room: Grays Peak

Speaker 5 of 5
Anna Maria Tochowicz, Amgen, USA
Short Talk: New Drug Leads for Chagas’ Disease Identified by Fragment Chemistry and Structural Analysis

Thursday, January 26 | 4:30PM - 6:15PM
Cellular Organization of Membrane Systems
This session is from Structural Biology
Room: Red Cloud

Speaker 1 of 4
* Axel T. Brunger, Stanford University, USA


Thursday, January 26 | 4:30PM - 6:15PM
Cellular Organization of Membrane Systems
This session is from Structural Biology
Room: Red Cloud

Speaker 2 of 4
Irina Serysheva, University of Texas-Houston Medical School, USA
Visualizing Transmembrane Helices in Calcium Release Channels by Single Particle Cryo-EM


Thursday, January 26 | 4:30PM - 6:15PM
Cellular Organization of Membrane Systems
This session is from Structural Biology
Room: Red Cloud

Speaker 3 of 4
Vinzenz M. Unger, Northwestern University, USA
Bending Boundaries - BAR Domain-Mediated Membrane Remodeling


Thursday, January 26 | 4:30PM - 6:15PM
Cellular Organization of Membrane Systems
This session is from Structural Biology
Room: Red Cloud

Speaker 4 of 4
Axel T. Brunger, Stanford University, USA
New Insights into the Mechanism of Calcium-Triggered Synaptic Vesicle Fusion by Single-Vesicle Content Mixing Microscopy and Single-Molecule Studies


Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 1 of 9
* Andrej Sali, University of California, San Francisco, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 2 of 9
Brian K. Shoichet, University of California, San Francisco, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 3 of 9
Barry Honig, Columbia University / HHMI, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 4 of 9
Margaret J. Gabanyi, PSI Structural Biology Knowledgebase - Rutgers University, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 5 of 9
Gaetano Thomas Montelione, Rutgers University, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 6 of 9
Michael G. Rossmann, Purdue University, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 7 of 9
David Baker, University of Washington, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 8 of 9
Adam Godzik, Sanford-Burnham Medical Research Institute, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them?
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 9 of 9
Cheryl Arrowsmith, University of Toronto, Canada

Thursday, January 26 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grays


Thursday, January 26 | 8:15PM - 11:00PM
Entertainment
Room: Grays


Thursday, January 26 | 8:30PM - 11:00PM
Cash Bar
Room: Quandary Peak


Friday, January 27 | 10:25AM - 10:25AM
Departure


*Session Chair.