Web Desc
Structural Biology of Cellular Processes: From Atoms to Cells
joint with High-Throughput Structural Biology
Organizer(s): Steven C. Almo, Anna Marie Pyle and Wah Chiu
Date: January 22 - 27, 2012
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
Cellular function requires the spatial and temporal coordination of complex processes over a remarkable range of length and time scales. Structural biology — including X-ray, EM and NMR approaches — has been instrumental in contributing to our mechanistic understanding of catalysis, molecular recognition and regulation, as well as in providing unique insights into modulating these processes to support therapeutic intervention. As these structural approaches have continued to mature, they have moved out of the realm of the specialist and are now an essential and indispensible part of modern biological discovery. The future promise of structural biology rests on our ability to integrate atomic resolution knowledge with results derived from cutting-edge microscopies and spectroscopies, as well as complementary genetic, biochemical and chemical biological methodologies. This symposium will highlight the power of multi-disciplinary, multi-scale integrative approaches for understanding and manipulating fundamental biological processes, including cell motility, chromosome maintence, gene regulation and membrane-associated phenomena. Participants will also have an opportunity to broaden their appreciation of advances in structural biology that can be used for studying complex cellular systems via the concurrent meeting on High-Throughput Structural Biology, which will share a keynote address and two plenary sessions with this meeting.
Scholarship Deadline: September 22 2011
Discounted Abstract Deadline: September 22 2011
Abstract Deadline: October 25 2011
Discounted Registration Deadline: November 22 2011


Shigeyuki Yokoyama
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM099406-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 22 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, January 22 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Sunday, January 22 | 7:15PM - 8:30PM
Welcome and Keynote Address (Joint)
Room: Longs/Grays Peaks

Speaker 1 of 3
* Ian A. Wilson, The Scripps Research Institute, USA

Sunday, January 22 | 7:15PM - 8:30PM
Welcome and Keynote Address (Joint)
Room: Longs/Grays Peaks

Speaker 2 of 3
* Steven C. Almo, Albert Einstein College of Medicine, USA

Sunday, January 22 | 7:15PM - 8:30PM
Welcome and Keynote Address (Joint)
Room: Longs/Grays Peaks

Speaker 3 of 3
Wayne A. Hendrickson, Columbia University, USA
Looking into the Future of Structure Biology: Next-Generation Synchrotrons and Applications for Biology

Monday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Monday, January 23 | 8:00AM - 11:15AM
Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 1 of 6
* Wayne A. Hendrickson, Columbia University, USA

Monday, January 23 | 8:00AM - 11:15AM
Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 2 of 6
Bo Huang, University of California, San Francisco, USA
Molecular Complexes under the Light Microscope

Monday, January 23 | 8:00AM - 11:15AM
Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 3 of 6
Brian K. Shoichet, University of California, San Francisco, USA
Chemical Networks in Pharmacology

Monday, January 23 | 8:00AM - 11:15AM
Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 4 of 6
Kurt Wüthrich, ETH Zürich, Switzerland
Solution NMR Studies of GPCR Structure and Function

Monday, January 23 | 8:00AM - 11:15AM
Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 5 of 6
Wah Chiu, Baylor College of Medicine, USA
Cryo-Electron Microscopy and Tomography of Viruses and Infected Cells

Monday, January 23 | 8:00AM - 11:15AM
Pushing the Limits of Structural Biology I: Innovative Metho
ds (Joint)

Room: Shavano/Red Cloud

Speaker 6 of 6
Graham T. Johnson, University of California, San Francisco, USA
Short Talk: Applications of Mesoscale Modeling and Visualization Software

Monday, January 23 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, January 23 | 11:15AM - 1:00PM
Poster Setup
Room: Grays


Monday, January 23 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, January 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays


Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Genomics
Room: Shavano

Speaker 1 of 10
* Andrej Sali, University of California, San Francisco, USA


Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Genomics
Room: Shavano

Speaker 2 of 10
Martin Beck, European Molecular Biology Laboratory, Germany
Investigating Human Nuclear Pore Composition by Targeted Mass Spectrometry


Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Genomics
Room: Shavano

Speaker 3 of 10
Franz Herzog, Gene Center Munich, Germany
Probing the Topology of Endogenous Human Protein Complexes by Chemical Cross-Linking and Mass Spectrometry


Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Genomics
Room: Shavano

Speaker 4 of 10
Nikolaos G. Sgourakis, University of California, Santa Cruz, USA
Advances in Structure Determination of Monomeric Proteins and Protein Complexes using Sparse NMR Data


Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Genomics
Room: Shavano

Speaker 5 of 10
John A. Tainer, The Scripps Research Institute, USA
Efficient Computational Assessments for Accurate Mass, Models and Resolution in Small-Angle Scattering Analyses


Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Genomics
Room: Shavano

Speaker 6 of 10
Charles H. Greenberg, University of California, San Francisco, USA
Threading a Protein Sequence onto its CryoEM Density Map


Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Genomics
Room: Shavano

Speaker 7 of 10
Gregory L. Warren, OpenEye Scientific Software Inc., USA
Automatic Ligand Conformer, Placement and Refinement Dictionary Generation Using Afitt


Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Genomics
Room: Shavano

Speaker 8 of 10
Ezgi Karaca, Utrecht University, Netherlands
A Flexible Multi-Domain Docking Approach to Deal with Large Conformational Changes in the Modeling of Biomolecular Complexes


Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Genomics
Room: Shavano

Speaker 9 of 10
David Hargreaves, AstraZeneca, UK
A Manual, Low-Cost Protein-Crystallisation Plate jig for in-situ Diffraction in the Home Laboratory


Monday, January 23 | 2:15PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Genomics
Room: Shavano

Speaker 10 of 10
M.Y. Heidari Khajehpour, Institut de Biologie Structurale, France
G-Rob with Crystal Listing Function for a New High Throughput in situ X-Ray Diffraction


Monday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 23 | 5:00PM - 7:15PM
Neurodegenerative and Misfolding Diseases
Room: Red Cloud

Speaker 1 of 6
* Kurt Wüthrich, ETH Zürich, Switzerland

Monday, January 23 | 5:00PM - 7:15PM
Neurodegenerative and Misfolding Diseases
Room: Red Cloud

Speaker 2 of 6
Gregory A. Petsko, Brandeis University, USA
Structural and Genetic Basis of Neurodegenerative Diseases

Monday, January 23 | 5:00PM - 7:15PM
Neurodegenerative and Misfolding Diseases
Room: Red Cloud

Speaker 3 of 6
Raquel L. Lieberman, Georgia Institute of Technology, USA
Structural and Biophysical Insights into the Olfactomedin Domain of Myocilin: Implications for Glaucoma

Monday, January 23 | 5:00PM - 7:15PM
Neurodegenerative and Misfolding Diseases
Room: Red Cloud

Speaker 4 of 6
Robert G. Griffin, Massachusetts Institute of Technology, USA
Atomic Resolution Structures of Amyloid Fibrils

Monday, January 23 | 5:00PM - 7:15PM
Neurodegenerative and Misfolding Diseases
Room: Red Cloud

Speaker 5 of 6
Andy Baldwin, University of Toronto, Canada
Short Talk: NMR Spectroscopy, Mass Spectrometry and Electron Microscopy Elucidate the Structure and Dynamics of alphaB-Crystallin Oligomers

Monday, January 23 | 5:00PM - 7:15PM
Neurodegenerative and Misfolding Diseases
Room: Red Cloud

Speaker 6 of 6
David E. Timm, Eli Lilly and Company, USA
Short Talk: Fragment-Based Design and Clinical Translation of BACE Inhibitors

Monday, January 23 | 5:00PM - 7:00PM
Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination
This session is from Structural Genomics

Room: Shavano

Speaker 1 of 6
* Andrzej Joachimiak, Argonne National Laboratory, USA


Monday, January 23 | 5:00PM - 7:00PM
Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination
This session is from Structural Genomics

Room: Shavano

Speaker 2 of 6
Imre Berger, EMBL Grenoble, France
Complexomics: New Tools and Strategies for Producing Eukaryotic Multiprotein Assemblies


Monday, January 23 | 5:00PM - 7:00PM
Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination
This session is from Structural Genomics

Room: Shavano

Speaker 3 of 6
Shohei Koide, New York University Langone Health, USA
Designer Binding Proteins for Controlling Biology


Monday, January 23 | 5:00PM - 7:00PM
Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination
This session is from Structural Genomics

Room: Shavano

Speaker 4 of 6
Christopher G. Tate, MRC Laboratory of Molecular Biology, UK
Conformational Thermostabilization and Engineering of Integral Membrane Proteins for Structural Studies


Monday, January 23 | 5:00PM - 7:00PM
Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination
This session is from Structural Genomics

Room: Shavano

Speaker 5 of 6
Shin-ichi Makino, University of Wisconson, Madison / CESG, USA
Short Talk: Strategies for Membrane Protein Preparation at the Transmembrane Protein Center Utilizing Cell-Free and Cell-based Systems


Monday, January 23 | 5:00PM - 7:00PM
Advances in Protein Expression, Engineering and Crystallizat
ion for Structure Determination
This session is from Structural Genomics

Room: Shavano

Speaker 6 of 6
José Antonio Márquez, European Molecular Biology Laboratory (EMBL), France
Short Talk: Crystal Direct : A New System for Automated Crystal Harvesting.


Monday, January 23 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grays


Monday, January 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Grays


Tuesday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Tuesday, January 24 | 8:00AM - 11:00AM
Dynamical Machines in RNA Metabolism
Room: Red Cloud

Speaker 1 of 5
Leemor Joshua-Tor, HHMI/Cold Spring Harbor Laboratory, USA
Coupling RNAi to Heterochromatin: Insights into the Structural Core of the RITS Complex

Tuesday, January 24 | 8:00AM - 11:00AM
Dynamical Machines in RNA Metabolism
Room: Red Cloud

Speaker 2 of 5
* Anna Marie Pyle, Yale University, USA
Determinants of Splicing

Tuesday, January 24 | 8:00AM - 11:00AM
Dynamical Machines in RNA Metabolism
Room: Red Cloud

Speaker 3 of 5
Holger Stark, Max Planck Institute for Biophysical Chemistry, Germany
Biochemical Stabilization and 3D Structure Determination of Dynamic Macromolecular Complexes

Tuesday, January 24 | 8:00AM - 11:00AM
Dynamical Machines in RNA Metabolism
Room: Red Cloud

Speaker 4 of 5
Alfonso Mondragón, Northwestern University, USA
Structure and Mechanism of Bacterial RNase P

Tuesday, January 24 | 8:00AM - 11:00AM
Dynamical Machines in RNA Metabolism
Room: Red Cloud

Speaker 5 of 5
John P. Marino, National Institute of Standards and Technology, USA
Short Talk: Structural Determinants of the Dimerization and Maturation of the HIV-1 Genomic RNA Dimerization Initiation Site

Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination
This session is from Structural Genomics

Room: Shavano

Speaker 1 of 7
* Carol V. Robinson, University of Oxford, UK


Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination
This session is from Structural Genomics

Room: Shavano

Speaker 2 of 7
Michael G. Rossmann, Purdue University, USA
Electron Microscopy, X-Ray Crystallography and Molecular Modeling for Structural Determination


Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination
This session is from Structural Genomics

Room: Shavano

Speaker 3 of 7
David Baker, University of Washington, USA
Structure Determination using Sparse Experimental Data


Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination
This session is from Structural Genomics

Room: Shavano

Speaker 4 of 7
Jianpeng Ma, Baylor College of Medicine, USA
Normal-Mode Refinement of Highly-Mobile X-Ray Structures at Lower Resolutions


Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination
This session is from Structural Genomics

Room: Shavano

Speaker 5 of 7
Andrej Sali, University of California, San Francisco, USA
Integrative Structure Determination


Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination
This session is from Structural Genomics

Room: Shavano

Speaker 6 of 7
Debora Marks, Harvard Medical School, USA
Short Talk: 3D Protein Structure Predicted de novo from Evolutionary Sequence Variation


Tuesday, January 24 | 8:00AM - 11:15AM
Advances in Computational and Hybrid Approaches to Structure
Determination
This session is from Structural Genomics

Room: Shavano

Speaker 7 of 7
Torsten Schwede, Biozentrum University of Basel & Swiss Institute of Bioinformatics, Switzerland
Short Talk: CAMEO - Continuous Automated Evaluation of Protein Structure Prediction Servers


Tuesday, January 24 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, January 24 | 11:00AM - 1:00PM
Poster Setup
Room: Grays


Tuesday, January 24 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, January 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays


Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
This session is from Structural Genomics
Room: Shavano

Speaker 1 of 10
* Cheryl Arrowsmith, University of Toronto, Canada


Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
This session is from Structural Genomics
Room: Shavano

Speaker 2 of 10
Andrew B. Ward, The Scripps Research Institute, USA
Using Electron Microscopy to Rapidly Characterize the Interaction of Neutralizing Antibodies with Viral Envelope Proteins


Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
This session is from Structural Genomics
Room: Shavano

Speaker 3 of 10
Susanne Gräslund, University of Toronto, Canada
A Pipeline to Generate Recombinant Monoclonal Antibodies to Human Target Proteins Linked to Epigenetic Mechanisms


Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
This session is from Structural Genomics
Room: Shavano

Speaker 4 of 10
John L. Markley, University of Wisconsin-Madison, USA
PSI:Biology Mitochondrial Protein Partnership - Mission and Progress


Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
This session is from Structural Genomics
Room: Shavano

Speaker 5 of 10
Dušan Turk, Jozef Stefan Institute, Slovenia
Studies of Endosomal Proteins Involved in Immune Response and Their Targets from Human Pathogens


Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
This session is from Structural Genomics
Room: Shavano

Speaker 6 of 10
Andrzej Joachimiak, Argonne National Laboratory, USA
Glycoside Hydrolases from the Human Gut Microbiome


Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
This session is from Structural Genomics
Room: Shavano

Speaker 7 of 10
Gaetano Thomas Montelione, Rutgers University, USA
Critical Assessment of Automated Protein Structure Determination by NMR


Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
This session is from Structural Genomics
Room: Shavano

Speaker 8 of 10
Kevin S. Keating, Yale University, USA
Semi-Automated Model Building for RNA Crystallography


Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
This session is from Structural Genomics
Room: Shavano

Speaker 9 of 10
Juri Rappsilber, Wellcome Trust Centre, University of Edinburgh, UK
Structural Biology by Mass Spectrometry: 3D Proteomics of Supramolecular Assemblies


Tuesday, January 24 | 2:15PM - 4:30PM
Workshop 2: High-Throughput Approaches to the Structure and
Function of Macromolecules and Biological Systems
This session is from Structural Genomics
Room: Shavano

Speaker 10 of 10
Margaret J. Gabanyi, PSI Structural Biology Knowledgebase - Rutgers University, USA
The PSI SBKB: A One-Stop Shop for Protein, Models, Functions, Methods and More


Tuesday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, January 24 | 5:00PM - 7:05PM
Cytoskeletal Organization and Function
Room: Red Cloud

Speaker 1 of 6
* Michael K. Rosen, University of Texas Southwestern Medical Center, USA

Tuesday, January 24 | 5:00PM - 7:05PM
Cytoskeletal Organization and Function
Room: Red Cloud

Speaker 2 of 6
Neil Q. McDonald, Cancer Research UK, UK
Molecular Analysis of a G-Actin Sensor

Tuesday, January 24 | 5:00PM - 7:05PM
Cytoskeletal Organization and Function
Room: Red Cloud

Speaker 3 of 6
Ohad Medalia, Zurich University, Switzerland
Structural Study on Cell Adhesion by Cryo-Electron Tomography

Tuesday, January 24 | 5:00PM - 7:05PM
Cytoskeletal Organization and Function
Room: Red Cloud

Speaker 4 of 6
Anne Houdusse, Institut Curie, France
How Myosin Motors Powers Cellular Functions: New Insights from Coupling Structural and Functional Insights

Tuesday, January 24 | 5:00PM - 7:05PM
Cytoskeletal Organization and Function
Room: Red Cloud

Speaker 5 of 6
Nathaniel L. Elsen, AbbVie, Inc., USA
Short Talk: Biochemical and Structural Basis for the Abolition of S. aureus FtsZ Polymerization Cooperativity by the Cell-Division Inhibitor PC190723

Tuesday, January 24 | 5:00PM - 7:05PM
Cytoskeletal Organization and Function
Room: Red Cloud


Short Talk Chosen from Abstracts

Tuesday, January 24 | 5:25PM - 7:15PM
Advances in Membrane Proteins
This session is from Structural Genomics
Room: Shavano

Speaker 1 of 6
* Andrew B. Ward, The Scripps Research Institute, USA


Tuesday, January 24 | 5:25PM - 7:15PM
Advances in Membrane Proteins
This session is from Structural Genomics
Room: Shavano

Speaker 2 of 6
Robert M. Stroud, University of California, San Francisco, USA
Structures of Membrane Proteins and Multimeric Membrane Protein Complexes


Tuesday, January 24 | 5:25PM - 7:15PM
Advances in Membrane Proteins
This session is from Structural Genomics
Room: Shavano

Speaker 3 of 6
Brian K. Kobilka, Stanford University School of Medicine, USA
Structural Insights into the Dynamic Process of G Protein Coupled Receptor Activation


Tuesday, January 24 | 5:25PM - 7:15PM
Advances in Membrane Proteins
This session is from Structural Genomics
Room: Shavano

Speaker 4 of 6
Raymond Stevens, ShanghaiTech University and University of Southern California, USA
Understanding G-protein Coupled Receptor Molecular Recognition and Structural Diversity


Tuesday, January 24 | 5:25PM - 7:15PM
Advances in Membrane Proteins
This session is from Structural Genomics
Room: Shavano

Speaker 5 of 6
Tracy M. Handel, University of California, San Diego, USA
Short Talk: Chemokine Receptors in Cell Signaling and Movement


Tuesday, January 24 | 5:25PM - 7:15PM
Advances in Membrane Proteins
This session is from Structural Genomics
Room: Shavano

Speaker 6 of 6
Petra Fromme, Arizona State University, USA
Short talk: Femtosecond Nanocrystallography of Membrane Proteins


Tuesday, January 24 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grays


Tuesday, January 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Grays


Wednesday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 1 of 7
* Wah Chiu, Baylor College of Medicine, USA

Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 2 of 7
Carolyn A. Larabell, University of California, San Francisco, USA
X-Ray Tomography of Organisms and Organelles

Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 3 of 7
Carol V. Robinson, University of Oxford, UK
The Flight of Intact V-Type ATPases Provides a New Phase for Exploring Subunit Interactions and the Functional Role of Nucleotide and Lipid Binding

Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 4 of 7
Timothy O. Street, University of California, San Francisco, USA
Short Talk: Extracting Mechanistic Information about the Hsp90 Molecular Chaperone with a Model Unfolded Protein Substrate

Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 5 of 7
Lewis E. Kay, University of Toronto, Canada
Seeing the Invisible by Solution - NMR Spectroscopy

Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 6 of 7
A. Joshua Wand, University of Pennsylvania, USA
Short Talk: Walking on Water: Enabling Site-Resolved Measurement of Hydration Dynamics with Solution NMR

Wednesday, January 25 | 8:00AM - 11:30AM
Pushing the Limits of Structural Biology II: Applications to
Biological Systems (Joint)

Room: Shavano/Red Cloud

Speaker 7 of 7
Barry Honig, Columbia University / HHMI, USA
Toward the Integration of Structural and Systems Biology: Structure-Based Prediction of Protein-Protein Interactions on a Genome-Wide Scale

Wednesday, January 25 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, January 25 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, January 25 | 4:00PM - 4:30PM
Coffee Available
Room: Foyer


Wednesday, January 25 | 4:30PM - 6:10PM
Signaling and Switches
Room: Red Cloud

Speaker 1 of 5
* Gregory A. Petsko, Brandeis University, USA

Wednesday, January 25 | 4:30PM - 6:10PM
Signaling and Switches
Room: Red Cloud

Speaker 2 of 5
Robert T. Batey, University of Colorado, Boulder, USA
Structure and Function of Riboswitches

Wednesday, January 25 | 4:30PM - 6:10PM
Signaling and Switches
Room: Red Cloud

Speaker 3 of 5
Michael K. Rosen, University of Texas Southwestern Medical Center, USA
Regulation of Actin Assembly from Angstroms to Microns

Wednesday, January 25 | 4:30PM - 6:10PM
Signaling and Switches
Room: Red Cloud

Speaker 4 of 5
Mark A. Lemmon, University of Pennsylvania Perelman School of Medicine, USA
Structural Basis for Ligand Regulation of Growth Factor Receptors

Wednesday, January 25 | 4:30PM - 6:10PM
Signaling and Switches
Room: Red Cloud

Speaker 5 of 5
Oliver Hantschel, Swiss Federal Institute of Technology Lausanne, Switzerland
Short Talk: Structural and Functional Analysis of the Regulation of the c-Abl and Bcr-Abl Tyrosine Kinases

Wednesday, January 25 | 4:30PM - 6:30PM
Novel Approaches to Decipher Function from Structure
This session is from Structural Genomics
Room: Shavano

Speaker 1 of 5
* Gaetano Thomas Montelione, Rutgers University, USA


Wednesday, January 25 | 4:30PM - 6:30PM
Novel Approaches to Decipher Function from Structure
This session is from Structural Genomics
Room: Shavano

Speaker 2 of 5
Nevan J. Krogan, University of California, San Francisco, USA
Advances in Characterization of Protein-Protein Interaction Networks


Wednesday, January 25 | 4:30PM - 6:30PM
Novel Approaches to Decipher Function from Structure
This session is from Structural Genomics
Room: Shavano

Speaker 3 of 5
John A. Gerlt, University of Illinois at Urbana-Champaign, USA
Discovering and Predicting New Functions in the Enolase Superfamily


Wednesday, January 25 | 4:30PM - 6:30PM
Novel Approaches to Decipher Function from Structure
This session is from Structural Genomics
Room: Shavano

Speaker 4 of 5
Adam Godzik, Sanford-Burnham Medical Research Institute, USA
Inferring Function from Structure and Genome Context


Wednesday, January 25 | 4:30PM - 6:30PM
Novel Approaches to Decipher Function from Structure
This session is from Structural Genomics
Room: Shavano

Speaker 5 of 5
William A. McLaughlin, Commonwealth Medical College, USA
Short Talk: KB-Role: An Online Resource for the Identification of Predicted Protein Functions and their Associated Probabilities


Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 1 of 10
* Ian A. Wilson, The Scripps Research Institute, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 2 of 10
Aled M. Edwards, University of Toronto, Canada

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 3 of 10
Gregory A. Petsko, Brandeis University, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 4 of 10
Wayne A. Hendrickson, Columbia University, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 5 of 10
Anna Marie Pyle, Yale University, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 6 of 10
Abby F. Dernburg, University of California, Berkeley, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 7 of 10
Robert M. Stroud, University of California, San Francisco, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 8 of 10
Andrzej Joachimiak, Argonne National Laboratory, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 9 of 10
Brian K. Kobilka, Stanford University School of Medicine, USA

Wednesday, January 25 | 6:30PM - 7:30PM
Debate 1: Is Structural Biology Being Hindered by Undue Defe
rence to Biology? (Joint)
Room: Shavano
Structure biology traditionally has focused on macromolecules and systems that have been well-characterized biochemically and biologically. As a result, extraordinary progress has been made on selected systems where structure has given many insights into function. However, with the advent or high throughput sequencing from the genomic sequencing centers, only a tiny fraction of the possible proteins in the protein universe are associated with structures. Many proteins are designated as hypothetical proteins or domains of unknown function (DUF) - to some that seems to mean that structural pursuit of these proteins is waste of time until their biology is known and akin to stamp collecting. Even in systems such as protein kinases where the family and function are well understood, only relatively few structures are in the PDB of the over 500 kinases predicted in the human genome. Furthermore, it is now difficult to publish a paper in a high profile journal without substantial supporting biological data, and it is even more unlikely that one will get funding for structures without function unless specifically earmarked by NIH and other agencies. Hence, in many ways, structural biologists could be considered as subservient to 'biologists' and should only pursue macromolecules where the biology is known. This pervading notion assumes that we will learn nothing from determining a structure first and then pursuing the biology later, or that these collections of structures by themselves teaches one little about the biology or have no other inherent value. Should structural biologists then continue to by and large work only on a few well chosen systems, or should they be allowed to break free of these biological shackles to be able to take a more Darwinian approach and explore the wonders of the protein universe all by themselves?
Speaker 10 of 10
James R. Williamson, The Scripps Research Institute, USA

Wednesday, January 25 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grays


Wednesday, January 25 | 7:45PM - 10:00PM
Workshop 3: Mega Poster Session on World-Wide Structural Bio
logy and Biology Center/Consortia and Large-Scale Databases and Repositories
This session is from Structural Genomics
Room: Grays
Structural biology centers and consortia highlight the platforms, new methods, technologies, databases, and computational tools that that have been developed to advance protein production and macromolecular structure determination for all classes of targets from bacterial to human and on challenging macromolecules, such as membrane proteins, eukaryotic proteins and protein complexes. Likewise, Biology centers will illustrate how they are using high throughput approaches to tackle challenging biological problems. Emphasis will be placed on what is applicable to the entire community, including single investigator laboratories to increase success and throughput in the study of biological macromolecules, complexes, and biological systems.


Thursday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
Room: Red Cloud

Speaker 1 of 7
* Anna Marie Pyle, Yale University, USA

Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
Room: Red Cloud

Speaker 2 of 7
Dylan J. Taatjes, University of Colorado Boulder, USA
Structure and Mechanism of the human Transcription Initiation Machinery

Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
Room: Red Cloud

Speaker 3 of 7
Abby F. Dernburg, University of California, Berkeley, USA
Imaging Chromosome Dynamics in Living Animals: Technical Challenges and Recent Advances

Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
Room: Red Cloud

Speaker 4 of 7
Antonina Roll-Mecak, DHHS/NINDS, National Institutes of Health, USA
Tales of Tubulin Tails: Insights into Tubulin Post-Translational Modifications

Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
Room: Red Cloud

Speaker 5 of 7
Sheena D'Arcy, HHMI/Colorado State University, USA
Conformation and Dynamics of Histone Proteins

Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
Room: Red Cloud

Speaker 6 of 7
Hal A. Lewis, Bristol-Myers Squibb, USA
Short Talk: Crystal Structure of Inhibitor-Bound H1N1 Influenza Nucleoprotein Reveals Mode of Higher-Order Oligomerization

Thursday, January 26 | 8:00AM - 11:15AM
Chromosome Organization and Function
Room: Red Cloud

Speaker 7 of 7
Ryan Rochat, Baylor College of Medicine, USA
Short Talk: Zernike Phase Contrast Cryo-Em Reveals the Structure of the Genome Packaging Apparatus in Herpes Simplex Virus

Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems
This session is from Structural Genomics

Room: Shavano

Speaker 1 of 7
* Aled M. Edwards, University of Toronto, Canada


Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems
This session is from Structural Genomics

Room: Shavano

Speaker 2 of 7
Udo Oppermann, University of Oxford, UK
Targeting the Histone Demethylome


Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems
This session is from Structural Genomics

Room: Shavano

Speaker 3 of 7
Cheryl Arrowsmith, University of Toronto, Canada
Structural and Chemical Biology of the Readers of the Histone Code


Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems
This session is from Structural Genomics

Room: Shavano

Speaker 4 of 7
James R. Williamson, The Scripps Research Institute, USA
Short Talk: Structural Genomics of Ribonucleoprotein Complexes Involved in T-Cell Activation


Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems
This session is from Structural Genomics

Room: Shavano

Speaker 5 of 7
Steven C. Almo, Albert Einstein College of Medicine, USA
Challenges and Opportunities for High-Throughput Structural Biology of Eukaryotic Systems


Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems
This session is from Structural Genomics

Room: Shavano

Speaker 6 of 7
Ian A. Wilson, The Scripps Research Institute, USA
Exploration of the Human Gut Microbiome


Thursday, January 26 | 8:00AM - 11:25AM
High-Throughput Structural Biology Applied to Biological Sys
tems
This session is from Structural Genomics

Room: Shavano

Speaker 7 of 7
Lance Stewart, Institute for Protein Design at University of Washington, USA
Short Talk: SGCID: Four Hundred Protein Structures from Microbial Pathogens


Thursday, January 26 | 9:00AM - 9:20AM
Coffee Break
Room: Foyer


Thursday, January 26 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, January 26 | 4:00PM - 4:30PM
Coffee Available
Room: Foyer


Thursday, January 26 | 4:30PM - 6:15PM
Cellular Organization of Membrane Systems
Room: Red Cloud

Speaker 1 of 4
* Axel T. Brunger, Stanford University, USA

Thursday, January 26 | 4:30PM - 6:15PM
Cellular Organization of Membrane Systems
Room: Red Cloud

Speaker 2 of 4
Irina Serysheva, University of Texas-Houston Medical School, USA
Visualizing Transmembrane Helices in Calcium Release Channels by Single Particle Cryo-EM

Thursday, January 26 | 4:30PM - 6:15PM
Cellular Organization of Membrane Systems
Room: Red Cloud

Speaker 3 of 4
Vinzenz M. Unger, Northwestern University, USA
Bending Boundaries - BAR Domain-Mediated Membrane Remodeling

Thursday, January 26 | 4:30PM - 6:15PM
Cellular Organization of Membrane Systems
Room: Red Cloud

Speaker 4 of 4
Axel T. Brunger, Stanford University, USA
New Insights into the Mechanism of Calcium-Triggered Synaptic Vesicle Fusion by Single-Vesicle Content Mixing Microscopy and Single-Molecule Studies


Thursday, January 26 | 4:30PM - 6:15PM
From Drug Targets to High-Throughput Structural Biology to t
he Clinic
This session is from Structural Genomics

Room: Grays Peak

Speaker 1 of 5
* Brian K. Shoichet, University of California, San Francisco, USA


Thursday, January 26 | 4:30PM - 6:15PM
From Drug Targets to High-Throughput Structural Biology to t
he Clinic
This session is from Structural Genomics

Room: Grays Peak

Speaker 2 of 5
James C. Sacchettini, Texas A & M University, USA
New Approaches to Identifying Antibacterial Drug Targets and Drug Discovery


Thursday, January 26 | 4:30PM - 6:15PM
From Drug Targets to High-Throughput Structural Biology to t
he Clinic
This session is from Structural Genomics

Room: Grays Peak

Speaker 3 of 5
Aled M. Edwards, University of Toronto, Canada
Structural Genomics and Drug Discovery


Thursday, January 26 | 4:30PM - 6:15PM
From Drug Targets to High-Throughput Structural Biology to t
he Clinic
This session is from Structural Genomics

Room: Grays Peak

Speaker 4 of 5
Jonathan M. Moore, Vertex Pharmaceuticals Incorporated, USA
Short Talk: The Ectodomain Complex of the CGRP Receptor: Insights into Antagonism of a Class B GPRC


Thursday, January 26 | 4:30PM - 6:15PM
From Drug Targets to High-Throughput Structural Biology to t
he Clinic
This session is from Structural Genomics

Room: Grays Peak

Speaker 5 of 5
Anna Maria Tochowicz, Amgen, USA
Short Talk: New Drug Leads for Chagas’ Disease Identified by Fragment Chemistry and Structural Analysis


Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them? (Joint)
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 1 of 9
* Andrej Sali, University of California, San Francisco, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them? (Joint)
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 2 of 9
Brian K. Shoichet, University of California, San Francisco, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them? (Joint)
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 3 of 9
Barry Honig, Columbia University / HHMI, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them? (Joint)
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 4 of 9
Margaret J. Gabanyi, PSI Structural Biology Knowledgebase - Rutgers University, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them? (Joint)
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 5 of 9
Gaetano Thomas Montelione, Rutgers University, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them? (Joint)
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 6 of 9
Michael G. Rossmann, Purdue University, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them? (Joint)
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 7 of 9
David Baker, University of Washington, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them? (Joint)
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 8 of 9
Adam Godzik, Sanford-Burnham Medical Research Institute, USA

Thursday, January 26 | 6:15PM - 7:15PM
Debate 2: What Use Are the Ever-Accumulating Mountains of St
ructures and Associated Data, If It Takes Years, If Ever, to Use and Appreciate Them? (Joint)
Room: Shavano
Structural genomics and high-throughput structural biology have been criticized in the past for determining atomic-level macromolecular structures without accompanying functional characterization. But most of us contribute to some extent to this mountain of structures often with little associated biology. This issue will be revisited in light of the design of PSI:Biology and other world-wide HTP centers. Panelists will consider various applications of these experimentally determined structures and associated datasets by experimental and computational biologists alike. Panelists will also discuss the immediate and mid-term impact of structures of macromolecules and their assemblies at atomic as well as at lower resolutions. A key question then is how to maximize the impact of structural biology on biology.
Speaker 9 of 9
Cheryl Arrowsmith, University of Toronto, Canada

Thursday, January 26 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grays


Thursday, January 26 | 8:00PM - 11:00PM
Cash Bar
Room: Quandary Peak


Thursday, January 26 | 8:15PM - 11:00PM
Entertainment
Room: Grays


Friday, January 27 | 10:25AM - 10:25AM
Departure


*Session Chair.