Web Desc
Pathogenesis of Diabetes: Emerging Insights into Molecular Mechanisms
joint with Genetic and Molecular Basis of Obesity and Body Weight Regulation
Organizer(s): Alan D. Attie, Christopher B. Newgard and Philipp E. Scherer
Date: January 29 - February 03, 2012
Location: Santa Fe Community Convention Center, Santa Fe, NM, USA
Sponsored by Pfizer Inc. and MedImmune
Summary of Meeting:
This meeting will focus on genetic, epigenetic and biochemical mechanisms underlying the pathogenesis of diabetes. New methods, particularly proteomics and the ability to interrogate protein modifications (phosphorylation, acetylation, methylation) on a large scale, are providing a new window into the pathological processes in type 2 diabetes. Other emerging themes are the CNS control of metabolism, the role of the microbiome in regulating metabolism, and transdifferentiation of cells in the endocrine pancreas in the adaptive response to obesity and insulin resistance. The strength of this meeting lies in the interdisciplinary nature of these topics. Pathogenesis of Diabetes: Emerging Insights into Molecular Mechanisms is held jointly with a the Keystone Symposia meeting on Genetic and Molecular Basis of Obesity and Body Weight Regulation, an obvious match with any conference devoted to type 2 diabetes; for example, adipose tissue function is dramatically changed in obesity, and adipocytes and adipose tissue immune cells produce proteins that modulate insulin signaling.
Scholarship Deadline: September 29 2011
Discounted Abstract Deadline: September 29 2011
Abstract Deadline: November 1 2011
Discounted Registration Deadline: November 29 2011
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
MedImmunePfizer Inc.
We gratefully acknowledge additional support for this conference from:
CEDARLANECell Signaling Technology, Inc.
Journal of Lipid Research
Mercodia, Inc.Novartis Institutes for BioMedical ResearchSeahorse Bioscience, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Bristol-Myers Squibb Company

Eli Lilly and Company

Metabolic Solutions Development Company, LLC.


Marc Prentki
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-03
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 29 | 3:00PM - 7:30PM
Registration
Room: Sweeney Ballroom Foyer


Sunday, January 29 | 6:15PM - 7:15PM
Refreshments
Room: Sweeney F, Main Level Breakout Rooms


Sunday, January 29 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 4
* Alan D. Attie, University of Wisconsin-Madison, USA

Sunday, January 29 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 4
* Evan D. Rosen, Harvard University, USA

Sunday, January 29 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 4
Aldons J. Lusis, University of California, Los Angeles, USA
Systems Genetics Analysis of Complex Interactions in Cardiometabolic Traits

Sunday, January 29 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 4
Daniel J. Rader, University of Pennsylvania, USA
From GWAS to Gene Function: Genetics and Physiology of Lipid and Lipoprotein Metabolism

Monday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakout Rooms


Monday, January 30 | 8:00AM - 11:15AM
Inflammation, ER Stress, Insulin Resistance (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 7
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Monday, January 30 | 8:00AM - 11:15AM
Inflammation, ER Stress, Insulin Resistance (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 7
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Novel Aspects of Insulin Action and their Role in Development of Insulin Resistance

Monday, January 30 | 8:00AM - 11:15AM
Inflammation, ER Stress, Insulin Resistance (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 7
Jeffrey M. Friedman, Rockefeller University, USA
Leptin: From Production to Pathways

Monday, January 30 | 8:00AM - 11:15AM
Inflammation, ER Stress, Insulin Resistance (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 7
Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Inflammation and ER Stress in Obesity and Diabetes

Monday, January 30 | 8:00AM - 11:15AM
Inflammation, ER Stress, Insulin Resistance (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 7
Bruce M. Spiegelman, Harvard Medical School, USA
Irisin, a Novel Myokine that Browns Adipose Tissues and Ameliorates Metabolic Disease

Monday, January 30 | 8:00AM - 11:15AM
Inflammation, ER Stress, Insulin Resistance (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 7
Alexander Rauch, University of Southern Denmark, Denmark
Short Talk: Glucocorticoids Dampen Insulin Sensitivity via the Dimerisation of the Glucocorticoid Receptor in Peripheral Organs

Monday, January 30 | 8:00AM - 11:15AM
Inflammation, ER Stress, Insulin Resistance (Joint)
Room: Sweeney Ballroom A-E

Speaker 7 of 7
Susan J. Gray, University of Massachusetts Medical School, USA
Short Talk: KLF15: A Critical Link between Insulin Resistance and ER Stress

Monday, January 30 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakout Rooms


Monday, January 30 | 11:15AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakout Rooms


Monday, January 30 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakout Rooms


Monday, January 30 | 2:30PM - 4:30PM
Workshop 1: Health Disparities (Joint). Supported by Novart
is Institutes for BioMedical Research
Room: Sweeney Ballroom A-B

Speaker 1 of 3
* William C. Hsu, Harvard Medical School, Joslin Diabetes Center, USA
Biology and Clinical Implications of Diabetes in Asian Americans

Monday, January 30 | 2:30PM - 4:30PM
Workshop 1: Health Disparities (Joint). Supported by Novart
is Institutes for BioMedical Research
Room: Sweeney Ballroom A-B

Speaker 2 of 3
Charles N. Rotimi, NHGRI, National Institutes of Health, USA
Genetics, Environment and Health Disparities in Diabetes among African Americans

Monday, January 30 | 2:30PM - 4:30PM
Workshop 1: Health Disparities (Joint). Supported by Novart
is Institutes for BioMedical Research
Room: Sweeney Ballroom A-B

Speaker 3 of 3
Struan F. A. Grant, Children’s Hospital of Philadelphia Research Institute, USA
Genome Wide Studies of Pediatric Metabolic Traits in Multi-Ethnic Settings

Monday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakout Rooms


Monday, January 30 | 5:00PM - 7:00PM
Islet Biology
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Christopher B. Newgard, Duke University Medical Center, USA

Monday, January 30 | 5:00PM - 7:00PM
Islet Biology
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Debbie C. Thurmond, Indiana University School of Medicine, USA
Molecular Regulators of Insulin Exocytosis

Monday, January 30 | 5:00PM - 7:00PM
Islet Biology
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Anil Bhushan, University of California, San Francisco, USA
Epigenetics Control of Islet Formation and Regeneration

Monday, January 30 | 5:00PM - 7:00PM
Islet Biology
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
Growth Factor Signaling in the Regulation of Islet Function and Proliferation

Monday, January 30 | 5:00PM - 7:00PM
Islet Biology
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Wook Kim, Ajou University, South Korea
Short Talk: Cannabinoids Induce Pancreatic Beta-Cell Death by Directly Inhibiting Insulin Receptor Activation

Monday, January 30 | 5:00PM - 7:00PM
Lipid Droplets and Lipid Handling
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Deborah M. Muoio, Duke University Medical Center, USA


Monday, January 30 | 5:00PM - 7:00PM
Lipid Droplets and Lipid Handling
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 2 of 5
Dawn L. Brasaemle, Rutgers University, USA
Control of Lipolysis by Perilipins


Monday, January 30 | 5:00PM - 7:00PM
Lipid Droplets and Lipid Handling
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 3 of 5
Rudolf Zechner, University of Graz, Austria
Mouse Models of Altered Lipolysis


Monday, January 30 | 5:00PM - 7:00PM
Lipid Droplets and Lipid Handling
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Tobias C. Walther, Harvard School of Public Health, USA
Mechanisms of Lipid Droplet Growth


Monday, January 30 | 5:00PM - 7:00PM
Lipid Droplets and Lipid Handling
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 5 of 5
Sheila Collins, Vanderbilt University Medical Center, USA
Short Talk: Cardiac Natriuretic Peptides Act via p38 MAPK to Induce the Brown Fat Thermogenic Program in Mouse and Human Adipocytes


Monday, January 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakout Rooms


Monday, January 30 | 7:30PM - 10:00PM
Poster Session 1
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, January 31 | 8:00AM - 11:15AM
Genetics (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 7
* Aldons J. Lusis, University of California, Los Angeles, USA

Tuesday, January 31 | 8:00AM - 11:15AM
Genetics (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 7
Alan D. Attie, University of Wisconsin-Madison, USA
Genes for Type 2 Diabetes from Genetics and Genomics

Tuesday, January 31 | 8:00AM - 11:15AM
Genetics (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 7
Joseph H. Nadeau, Maine Medical Center Research Institute, USA
Epistasis, Fractal Genetics and Systems Properties of Metabolic Traits

Tuesday, January 31 | 8:00AM - 11:15AM
Genetics (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 7
Sadaf Farooqi, University of Cambridge, UK
Genetics of Human Obesity-Monogenic Disorders

Tuesday, January 31 | 8:00AM - 11:15AM
Genetics (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 7
Joel N. Hirschhorn, Children's Hospital, Boston, USA
Genome-Wide Association Studies and Genetics of Human Obesity

Tuesday, January 31 | 8:00AM - 11:15AM
Genetics (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 7
Nuno Rocha, Institute of Metabolic Science, University of Cambridge, UK
Short Talk: ARL15: A Novel Player in Metabolic Disease

Tuesday, January 31 | 8:00AM - 11:15AM
Genetics (Joint)
Room: Sweeney Ballroom A-E

Speaker 7 of 7
Carl S. Thummel, University of Utah School of Medicine, USA
Short Talk: MPC1 Plays an Essential Role in Pyruvate Metabolism in Yeast, Drosophila, and Human Disease

Tuesday, January 31 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, January 31 | 11:15AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, January 31 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, January 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, January 31 | 5:00PM - 7:00PM
Novel Regulatory Pathways in Metabolism
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Steven A. Kliewer, University of Texas Southwestern Medical Center, USA

Tuesday, January 31 | 5:00PM - 7:00PM
Novel Regulatory Pathways in Metabolism
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Rana K. Gupta, University of Texas Southwestern Medical Center, USA
Developmental Origin and Molecular Control of Adipose Progenitors

Tuesday, January 31 | 5:00PM - 7:00PM
Novel Regulatory Pathways in Metabolism
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Matthias Hebrok, University of California, San Francisco, USA
Hypoxia and Beta-Cell Dysfunction

Tuesday, January 31 | 5:00PM - 7:00PM
Novel Regulatory Pathways in Metabolism
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Ajay Chawla, Merck Research Labs, USA
Innate Immune Cells Regulate Adipose Tissue Metabolism

Tuesday, January 31 | 5:00PM - 7:00PM
Novel Regulatory Pathways in Metabolism
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Ron F. Morrison, University of North Carolina, Greensboro, USA
Short Talk: Novel Mechanism of Golgi-Mediated TNFalpha-Induced
Inflammatory Gene Expression in Adipocytes


Tuesday, January 31 | 5:00PM - 7:00PM
Novel Aspects of Adipocyte Biology
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Sheila Collins, Vanderbilt University Medical Center, USA


Tuesday, January 31 | 5:00PM - 7:00PM
Novel Aspects of Adipocyte Biology
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 2 of 5
Juleen R. Zierath, Karolinska Institutet, Sweden
Genetic and Environmental Modulators of Insulin Sensitivity


Tuesday, January 31 | 5:00PM - 7:00PM
Novel Aspects of Adipocyte Biology
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 3 of 5
Barbara Cannon, Stockholm University, Sweden
Brown and Brite Adipose Tissues: Characteristics and Significance


Tuesday, January 31 | 5:00PM - 7:00PM
Novel Aspects of Adipocyte Biology
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Bart Staels, Institut Pasteur de Lille, Université Lille, France
Macrophage Polarization in Obesity and Atherosclerosis


Tuesday, January 31 | 5:00PM - 7:00PM
Novel Aspects of Adipocyte Biology
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 5 of 5
J. Andrew Pospisilik, Van Andel Institute, USA
Short Talk: Rapid Rewiring of Adipocyte Metabolism by a Novel Hedgehog-Ampk Axis


Tuesday, January 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, January 31 | 7:30PM - 10:00PM
Poster Session 2
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 01 | 8:00AM - 11:15AM
Integration of -Omics Data in Diabetes Research (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 7
* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

Wednesday, February 01 | 8:00AM - 11:15AM
Integration of -Omics Data in Diabetes Research (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 7
Christopher B. Newgard, Duke University Medical Center, USA
Metabolomics and Metabolic Disease

Wednesday, February 01 | 8:00AM - 11:15AM
Integration of -Omics Data in Diabetes Research (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 7
Christopher K. Glass, University of California, San Diego, USA
Genomics and Lipidomics of Macrophage Activation

Wednesday, February 01 | 8:00AM - 11:15AM
Integration of -Omics Data in Diabetes Research (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 7
Markus Stoffel, ETH Zürich, Switzerland
Exploring the beta Cell Surface Proteome and Secretome

Wednesday, February 01 | 8:00AM - 11:15AM
Integration of -Omics Data in Diabetes Research (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 7
Elaine Holmes, Imperial College London, UK
Systems Biology of the Gut Microbiome and Mammalian Metabolism

Wednesday, February 01 | 8:00AM - 11:15AM
Integration of -Omics Data in Diabetes Research (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 7
Cole Trapnell, University of Washington, USA
Short Talk: Long Noncoding RNAs Regulate Adipogenesis

Wednesday, February 01 | 8:00AM - 11:15AM
Integration of -Omics Data in Diabetes Research (Joint)
Room: Sweeney Ballroom A-E

Speaker 7 of 7
Ryan Berry, Yale University, USA
Short Talk: Analysis of Gene Networks in White Adipose Tissue Development Reveals a Role for ETS2 in Adipogenesis

Wednesday, February 01 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 01 | 11:15AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 01 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 01 | 1:00PM - 4:30PM
Workshop 2: New Therapeutic Targets and Challenges (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 10
* David E. Moller, Eli Lilly and Company, USA

Wednesday, February 01 | 1:00PM - 4:30PM
Workshop 2: New Therapeutic Targets and Challenges (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 10
Richard D. DiMarchi, Indiana University and Novo Nordisk, USA
Keynote Address: Multi-Functional Peptides Targeting Metabolic Disease

Wednesday, February 01 | 1:00PM - 4:30PM
Workshop 2: New Therapeutic Targets and Challenges (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 10
Simeon Taylor, University of Maryland School of Medicine, USA
SGLT2 Inhibition - Target to Clinical Proof-of-Concept - Lessons Learned

Wednesday, February 01 | 1:00PM - 4:30PM
Workshop 2: New Therapeutic Targets and Challenges (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 10
Dominic P. Behan, Sentia Medical Sciences, Inc., USA
GPR 119 Agonists for the Treatment of Diabetes

Wednesday, February 01 | 1:00PM - 4:30PM
Workshop 2: New Therapeutic Targets and Challenges (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 10
Thomas Kjeldsen, Novo Nordisk, Denmark
Engineering of Next Generation Insulin Analogues

Wednesday, February 01 | 1:00PM - 4:30PM
Workshop 2: New Therapeutic Targets and Challenges (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 10
David E. Kelley, Merck & Co., Inc., USA
Glucokinase Activators - Target Validation to In-Depth Clinical Testing

Wednesday, February 01 | 1:00PM - 4:30PM
Workshop 2: New Therapeutic Targets and Challenges (Joint)
Room: Sweeney Ballroom A-E

Speaker 7 of 10
Paul Emmerson, Eli Lilly and Company, USA
Short talk: Metabolic Actions through Modulation of FGF Receptor 1c Signaling

Wednesday, February 01 | 1:00PM - 4:30PM
Workshop 2: New Therapeutic Targets and Challenges (Joint)
Room: Sweeney Ballroom A-E

Speaker 8 of 10
Yang Li, Amgen Inc., USA
Short Talk: Novel Approaches to Targeting the FGF21 Pathway

Wednesday, February 01 | 1:00PM - 4:30PM
Workshop 2: New Therapeutic Targets and Challenges (Joint)
Room: Sweeney Ballroom A-E

Speaker 9 of 10
Patrick R. Griffin, The Scripps Research Institute, USA
Short Talk: PPARG Non-Agonists

Wednesday, February 01 | 1:00PM - 4:30PM
Workshop 2: New Therapeutic Targets and Challenges (Joint)
Room: Sweeney Ballroom A-E

Speaker 10 of 10
Rolf F. Kletzien, Metabolic Solutions Development, Inc., USA
Short Talk: Insulin Sensitization Through a Mitochondrial Metabolic Switch that Modulates Wnt Signaling

Wednesday, February 01 | 2:40PM - 3:00PM
Coffee Break
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 01 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 01 | 5:00PM - 7:00PM
New Concepts in Glucose Metabolism
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Morris F. White, Boston Children's Hospital, Harvard Medical School, USA

Wednesday, February 01 | 5:00PM - 7:00PM
New Concepts in Glucose Metabolism
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Regulation of Metabolic Pathways to Support Cell Proliferation

Wednesday, February 01 | 5:00PM - 7:00PM
New Concepts in Glucose Metabolism
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Donald A. McClain, University of Utah School of Medicine, USA
O-Glycosylation and Diabetes

Wednesday, February 01 | 5:00PM - 7:00PM
New Concepts in Glucose Metabolism
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Domenico Accili, Columbia University, USA
Identification of New Drug Targets to Treat Insulin Resistance in the CNS, Liver, and Pancreatic Beta-Cells

Wednesday, February 01 | 5:00PM - 7:00PM
New Concepts in Glucose Metabolism
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Nigel Beaton, Institute of Food, Nutrition and Health, Switzerland
Short Talk: Tusc5 Controls Insulin Mediated Glucose Uptake by Facilitating Glut4 Membrane Fusion

Wednesday, February 01 | 5:00PM - 7:00PM
Epigenetics
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Juleen R. Zierath, Karolinska Institutet, Sweden


Wednesday, February 01 | 5:00PM - 7:00PM
Epigenetics
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 2 of 5
Evan D. Rosen, Harvard University, USA
Epigenomics of Metabolic Dysfunction


Wednesday, February 01 | 5:00PM - 7:00PM
Epigenetics
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 3 of 5
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Cistromes and the Tissue-Specific Physiology of HDAC3


Wednesday, February 01 | 5:00PM - 7:00PM
Epigenetics
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Susanne Mandrup, University of Southern Denmark, Denmark
Hotspots Orchestrating Adipocyte Differentiation


Wednesday, February 01 | 5:00PM - 7:00PM
Epigenetics
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 5 of 5
Hironori Waki, University of Tokyo, Japan
Short Talk: Global Mapping of Cell-Type-Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte Differentiation


Wednesday, February 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 01 | 7:30PM - 10:00PM
Poster Session 3
Room: Sweeney F, Main Level Breakout Rooms


Thursday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakout Rooms


Thursday, February 02 | 7:30AM - 8:00AM
Poster Setup
Room: Sweeney F, Main Level Breakout Rooms


Thursday, February 02 | 8:00AM - 11:15AM
Hormones that Modulate Metabolism and Insulin Sensitivity (J
oint)

Room: Sweeney Ballroom A-E

Speaker 1 of 7
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Thursday, February 02 | 8:00AM - 11:15AM
Hormones that Modulate Metabolism and Insulin Sensitivity (J
oint)

Room: Sweeney Ballroom A-E

Speaker 2 of 7
Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA
FGF21: A New Player in Metabolic Homeostasis and Disease

Thursday, February 02 | 8:00AM - 11:15AM
Hormones that Modulate Metabolism and Insulin Sensitivity (J
oint)

Room: Sweeney Ballroom A-E

Speaker 3 of 7
Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
FGF21: From Feast to Famine

Thursday, February 02 | 8:00AM - 11:15AM
Hormones that Modulate Metabolism and Insulin Sensitivity (J
oint)

Room: Sweeney Ballroom A-E

Speaker 4 of 7
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Mechanistic Insights into Adipose Tissue and Hepatic Insulin Sensitivity

Thursday, February 02 | 8:00AM - 11:15AM
Hormones that Modulate Metabolism and Insulin Sensitivity (J
oint)

Room: Sweeney Ballroom A-E

Speaker 5 of 7
Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Novel Mechanisms by which Adipocytes Regulate Systemic Insulin Sensitivity

Thursday, February 02 | 8:00AM - 11:15AM
Hormones that Modulate Metabolism and Insulin Sensitivity (J
oint)

Room: Sweeney Ballroom A-E

Speaker 6 of 7
Lei Cao, Ohio State University, USA
Short Talk: White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Sympathoneural-Adipocyte Axis

Thursday, February 02 | 8:00AM - 11:15AM
Hormones that Modulate Metabolism and Insulin Sensitivity (J
oint)

Room: Sweeney Ballroom A-E

Speaker 7 of 7
Stephanie E. Simonds, Monash University, Australia
Short Talk: Hypertension in Obesity, is Leptin the Culprit?

Thursday, February 02 | 8:00AM - 7:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakout Rooms


Thursday, February 02 | 9:00AM - 9:20AM
Coffee Break
Room: Sweeney F, Main Level Breakout Rooms


Thursday, February 02 | 11:15AM - 12:00PM
Lunch
Room: Sweeney F, Main Level Breakout Rooms


Thursday, February 02 | 12:00PM - 2:30PM
Poster Session 4
Room: Sweeney F, Main Level Breakout Rooms


Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
Room: Sweeney Ballroom C-E

Speaker 1 of 8
* Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA

Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
Room: Sweeney Ballroom C-E

Speaker 2 of 8
Ahmed Kablan, National Institutes of Health, USA
Gs-alpha Deficiency in POMC Neurons Leads to Hyperglycemia with Reduced Serum Insulin Levels and Impaired Counterregulation to Hypoglycemia

Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
Room: Sweeney Ballroom C-E

Speaker 3 of 8
Craig Hammond, Eli Lilly and Company, USA
A Novel Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor Increases Plasma GLP-1 Levels and Reduces Body Weight Gain

Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
Room: Sweeney Ballroom C-E

Speaker 4 of 8
Shirly Pinto, Kallyope, USA
Mechanisms Underlying Diacylglycerol Acyltransferase 1 Inhibition – Potential insight into Modulation of Gut Peptides Release

Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
Room: Sweeney Ballroom C-E

Speaker 5 of 8
Sharon M. Blättler, Genomics Institute of the Novartis Research Foundation, USA
Yin Yang 1 Deficiency in Skeletal Muscle Protects Against Rapamycin-induced Diabetic-like Symptoms through Activation of Insulin/IGF Signaling

Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
Room: Sweeney Ballroom C-E

Speaker 6 of 8
Zheng Sun, Baylor College of Medicine, USA
Dissociation of Fatty Liver and Insulin Resistance in Mice Lacking Hepatic HDAC3

Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
Room: Sweeney Ballroom C-E

Speaker 7 of 8
Lale Ozcan, Columbia University, USA
Inhibition of Hepatic Calcium/Calmodulin-Dependent Protein Kinase II Protects against Obesity-Induced Insulin Resistance and Fatty Liver Formation

Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
Room: Sweeney Ballroom C-E

Speaker 8 of 8
Jose M. Irimia-Dominguez, Indiana University, USA
Inability to Synthesize Glycogen in Liver Leads to Enhanced Lipid Synthesis and Liver Insulin Resistance

Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 1 of 8
* Mary-Elizabeth Patti, Joslin Diabetes Center, USA


Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 2 of 8
Marin Gantner, Lowy Medical Research Institute, USA
Identification of a Novel Energy Expenditure Regulatory Pathway in Brown Adipose Tissue


Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 3 of 8
Wen Kong, Joslin Diabetes Center, USA
STARS Regulates AMPK Phosphorylation and Oxidative Capacity


Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 4 of 8
Susana Rodriguez, Johns Hopkins University School of Medicine, USA
Targeted Chemical-Genetic Metabolic Regulation in vivo


Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 5 of 8
Michael Lutter, University of Texas Southwestern Medical Center, USA
Melanocortin 4 Receptor Signaling in Habit/Procedural Memory Learning


Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 6 of 8
Kristy L. Townsend, University of Maine, USA
Deletion of Bone Morphogenetic Protein Receptor 1a (BMPR1a) in POMC Neurons Results in Hyperphagia and Increased Sympathetic Outflow to Brown and White Adipose Tissues


Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 7 of 8
Florian W. Kiefer, Brigham and Women's Hospital, Harvard Medical School, USA
Retinaldehyde Dehydrogenase 1 Determines a Thermogenic Program in White Adipose Tissue


Thursday, February 02 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Developments
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 8 of 8
James E. Minchin, Duke University, USA
Longitudinal in vivo Imaging in Zebrafish Reveals Oscillatory Hyperplastic and Hypertrophic Adipose Tissue Growth is Regulated by a Pre-Patterned Vascular Network


Thursday, February 02 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakout Rooms


Thursday, February 02 | 5:00PM - 7:00PM
Insulin Action
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

Thursday, February 02 | 5:00PM - 7:00PM
Insulin Action
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Michael P. Czech, University of Massachusetts Medical School, USA
New Insights into the Insulin Signaling Pathway

Thursday, February 02 | 5:00PM - 7:00PM
Insulin Action
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
The Regulation of Insulin Signaling by Serine/Threonine Phosphorylation of Irs1

Thursday, February 02 | 5:00PM - 7:00PM
Insulin Action
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Deborah M. Muoio, Duke University Medical Center, USA
Journal of Lipid Research Lectureship: Mechanisms of Fatty Acid-Induced Insulin Resistance

Thursday, February 02 | 5:00PM - 7:00PM
Insulin Action
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Min Lu, Merck Research Laboroatory, USA
Short Talk: Neuronal SIRT1 Deficiency Causes Central and Whole-Body Insulin Sensitivity

Thursday, February 02 | 5:00PM - 7:00PM
CNS Control of Metabolism
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 1 of 4
* Martin G. Myers, Jr., University of Michigan, USA
Leptin Signaling in the Brain


Thursday, February 02 | 5:00PM - 7:00PM
CNS Control of Metabolism
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 2 of 4
Allison W. Xu, University of California, San Francisco, USA
Adaptive Regulation of Energy Balance by Central Melanocortinergic Neurons


Thursday, February 02 | 5:00PM - 7:00PM
CNS Control of Metabolism
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 3 of 4
Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
CNS Control of Metabolism


Thursday, February 02 | 5:00PM - 7:00PM
CNS Control of Metabolism
This session is from Obesity
Room: Sweeney Ballroom A-B

Speaker 4 of 4
Yong Xu, Baylor College of Medicine, USA
Short Talk: CNS Circuitry Mediating Estrogenic Effects on Energy Homeostasis


Thursday, February 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakout Rooms


Thursday, February 02 | 8:00PM - 11:00PM
Entertainment
Room: Sweeney F, Main Level Breakout Rooms


Thursday, February 02 | 8:00PM - 11:00PM
Cash Bar
Room: Sweeney F, Main Level Breakout Rooms


Friday, February 03 | 10:25AM - 10:25AM
Departure


*Session Chair.