Web Desc
Advances in Hypoxic Signaling: From Bench to Bedside
joint with Cancer and Metabolism
Organizer(s): Volker H. Haase, Cormac T. Taylor, Johanna Myllyharju and Paul T. Schumacker
Date: February 12 - 17, 2012
Location: Fairmont Banff Springs, Banff, AB, Canada
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Changes in tissue oxygen levels are frequently associated with pathological conditions such as pulmonary, cardiovascular and neoplastic diseases, but also occur physiologically during development. Recent advances in understanding the molecular basis of cellular and systemic hypoxia responses have led to the discovery of novel therapeutic targets that have the potential to impact the treatment of ischemic and neoplastic diseases. This Keystone Symposia meeting on Advances in Hypoxic Signaling: From Bench to Bedside will provide a state-of-the-art overview and critical discussion of hypoxia research and will serve as a superb platform for scientific exchange between senior and junior investigators, including students. This meeting brings together leading experts in the field of hypoxic signaling and will: 1) discuss the most recent advances in the regulation of cellular and systemic hypoxia responses; 2) examine the role of hypoxia response pathways in embryonic development, tumorigenesis, tissue injury and repair, inflammation and metabolism; and 3) highlight the latest developments in therapeutic targeting of hypoxia response pathways. This meeting aims to further our understanding of the biological response to hypoxia and promote use of this information for therapeutic gain. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Cancer and Metabolism, which will share a keynote address and a plenary session with this meeting.
Scholarship Deadline: October 13 2011
Discounted Abstract Deadline: October 13 2011
Abstract Deadline: November 14 2011
Discounted Registration Deadline: December 12 2011
We gratefully acknowledge additional support for this conference from:
Coy Laboratory Products Inc.HypOxygenInQ Biosciences CorporationRuskinn Technology Ltd, a division of the Baker Company, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genzyme Corporation
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL110500-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 12 | 3:00PM - 7:30PM
Registration
Room: Van Horne Foyer


Sunday, February 12 | 6:15PM - 7:15PM
Refreshments
Room: Van Horne Foyer


Sunday, February 12 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne A-B

Speaker 1 of 4
* Volker H. Haase, Vanderbilt University, USA

Sunday, February 12 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne A-B

Speaker 2 of 4
Peter J. Ratcliffe, University of Oxford, UK
Regulation of Hypoxic Signaling: Past and Future

Sunday, February 12 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne A-B

Speaker 3 of 4
* Reuben J. Shaw, The Salk Institute for Biological Studies, USA

Sunday, February 12 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne A-B

Speaker 4 of 4
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Metabolism and Cancer Are Intertwined

Monday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Monday, February 13 | 8:00AM - 11:15AM
Transcriptional and Non-Transcriptional Regulation of Hypoxi
a Responses

Room: Van Horne C

Speaker 1 of 7
* Agnes Görlach, German Heart Center Munich, TU Munich, Germany

Monday, February 13 | 8:00AM - 11:15AM
Transcriptional and Non-Transcriptional Regulation of Hypoxi
a Responses

Room: Van Horne C

Speaker 2 of 7
Johanna Myllyharju, University of Oulu, Finland
Enzymatic Responses to Hypoxia

Monday, February 13 | 8:00AM - 11:15AM
Transcriptional and Non-Transcriptional Regulation of Hypoxi
a Responses

Room: Van Horne C

Speaker 3 of 7
Murray L. Whitelaw, Adelaide University, Australia
Signaling through bHLH/PAS Domain Proteins

Monday, February 13 | 8:00AM - 11:15AM
Transcriptional and Non-Transcriptional Regulation of Hypoxi
a Responses

Room: Van Horne C

Speaker 4 of 7
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Endothelial Metabolism: A Target in Angiogenesis?

Monday, February 13 | 8:00AM - 11:15AM
Transcriptional and Non-Transcriptional Regulation of Hypoxi
a Responses

Room: Van Horne C

Speaker 5 of 7
Peppi Koivunen, University of Oulu, Finland
Short Talk: Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation

Monday, February 13 | 8:00AM - 11:15AM
Transcriptional and Non-Transcriptional Regulation of Hypoxi
a Responses

Room: Van Horne C

Speaker 6 of 7
Roland H. Wenger, University of Zürich, Switzerland
Oxygen-Responsive Transcriptional Networks

Monday, February 13 | 8:00AM - 11:15AM
Transcriptional and Non-Transcriptional Regulation of Hypoxi
a Responses

Room: Van Horne C

Speaker 7 of 7
Florian Riess, German Heart Center Munich, Germany
Short Talk: HIF-3alpha Inhibits HIF-2 in Vascular Endothelial Cells by Dimerization with ARNT

Monday, February 13 | 8:00AM - 11:15AM
Oncogene Control of Metabolism
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 1 of 7
* David M. Sabatini, Whitehead Institute for Biomedical Research, USA


Monday, February 13 | 8:00AM - 11:15AM
Oncogene Control of Metabolism
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 2 of 7
Lewis C. Cantley, Weill Cornell Medicine, USA
PI3K and Mitogenic Signals Control Metabolism


Monday, February 13 | 8:00AM - 11:15AM
Oncogene Control of Metabolism
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 3 of 7
Michael Pollak, Jewish General Hospital, Canada
Actions of Insulin and myc on Cancer Metabolism are Influenced by Metformin


Monday, February 13 | 8:00AM - 11:15AM
Oncogene Control of Metabolism
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 4 of 7
Eileen P. White, Rutgers University, USA
Role of Autophagy and Metabolic Control in Tumorigenesis


Monday, February 13 | 8:00AM - 11:15AM
Oncogene Control of Metabolism
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 5 of 7
Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany
EMBO Young Investigator Lecture: Regulation of Lipogenesis by the Akt/mTORC1 Pathway and Its Role in Cell Growth and Cancer


Monday, February 13 | 8:00AM - 11:15AM
Oncogene Control of Metabolism
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 6 of 7
E. Alejandro Sweet-Cordero, Stanford University, USA
Short Talk: Oncogenic Kras Inhibits Mitochondrial Metabolism by Regulating the Pyruvate Dehydrogenase Complex under Conditions of Nutrient Stress


Monday, February 13 | 8:00AM - 11:15AM
Oncogene Control of Metabolism
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 7 of 7
Taru Muranen, Harvard Medical School, USA
Short Talk: Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells


Monday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Monday, February 13 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Monday, February 13 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Monday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Monday, February 13 | 2:30PM - 4:30PM
Workshop: Health Disparities (Joint). Supported by Novartis
Institutes for BioMedical Research
Room: Van Horne A-B

Speaker 1 of 3
* Timothy R. Rebbeck, University of Pennsylvania School of Medicine, USA
Introduction and Overview

Monday, February 13 | 2:30PM - 4:30PM
Workshop: Health Disparities (Joint). Supported by Novartis
Institutes for BioMedical Research
Room: Van Horne A-B

Speaker 2 of 3
Josef Prchal, University of Utah, USA
Congenital Disorders of Hypoxic Sensing and Tibetan Hypoxic Adaptation

Monday, February 13 | 2:30PM - 4:30PM
Workshop: Health Disparities (Joint). Supported by Novartis
Institutes for BioMedical Research
Room: Van Horne A-B

Speaker 3 of 3
Suzanne D. Conzen, University of Chicago, USA
Effects of Social Stressors on Cancer Progression: Potential Metabolic Mechanisms

Monday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Monday, February 13 | 5:00PM - 7:00PM
HIF Signaling in Cancer (Joint)
Room: Van Horne A-B

Speaker 1 of 5
* Eyal Gottlieb, Technion - Israel Institute of Technology, Israel

Monday, February 13 | 5:00PM - 7:00PM
HIF Signaling in Cancer (Joint)
Room: Van Horne A-B

Speaker 2 of 5
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Cancer Metabolism and 2-Oxoglutarate-dependent Dioxygenases

Monday, February 13 | 5:00PM - 7:00PM
HIF Signaling in Cancer (Joint)
Room: Van Horne A-B

Speaker 3 of 5
M. Celeste Simon, University of Pennsylvania, USA
Genetic Dissection of HIF Function in Cancer and Stem Cells

Monday, February 13 | 5:00PM - 7:00PM
HIF Signaling in Cancer (Joint)
Room: Van Horne A-B

Speaker 4 of 5
Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
Multiple Roles of Hypoxia-Inducible Factors in Breast Cancer Metastasis

Monday, February 13 | 5:00PM - 7:00PM
HIF Signaling in Cancer (Joint)
Room: Van Horne A-B

Speaker 5 of 5
Till Acker, University of Giessen, Germany
Short Talk: Control of Tumor Growth by Prolyl-Hydroxylases

Monday, February 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Monday, February 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Mezzanine 2


Tuesday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Tuesday, February 14 | 8:00AM - 11:15AM
Metabolic Adaptation to Hypoxia
Room: Van Horne C

Speaker 1 of 7
* Dörthe M. Katschinski, Georg August University, Germany

Tuesday, February 14 | 8:00AM - 11:15AM
Metabolic Adaptation to Hypoxia
Room: Van Horne C

Speaker 2 of 7
Randall S. Johnson, University of Cambridge, UK
Hypoxia and Metabolism

Tuesday, February 14 | 8:00AM - 11:15AM
Metabolic Adaptation to Hypoxia
Room: Van Horne C

Speaker 3 of 7
Lorenz Poellinger, Karolinska Institutet, Sweden
Epigenetic Control of Hypoxia Gene Expression and Metabolic Stress

Tuesday, February 14 | 8:00AM - 11:15AM
Metabolic Adaptation to Hypoxia
Room: Van Horne C

Speaker 4 of 7
Jenny E. Gunton, University of Sydney, Australia
HIF-1alpha in the Development of Type 2 Diabetes and Metabolic Syndrome

Tuesday, February 14 | 8:00AM - 11:15AM
Metabolic Adaptation to Hypoxia
Room: Van Horne C

Speaker 5 of 7
Calvin Kuo, Stanford University, USA
Short Talk: Hypoxic Regulation of Hepatic Glucose Metabolism

Tuesday, February 14 | 8:00AM - 11:15AM
Metabolic Adaptation to Hypoxia
Room: Van Horne C

Speaker 6 of 7
Martina U. Muckenthaler, Children's Hospital, University of Heidelberg, Germany
Oxygen-Dependent Regulation of Iron Metabolism

Tuesday, February 14 | 8:00AM - 11:15AM
Metabolic Adaptation to Hypoxia
Room: Van Horne C

Speaker 7 of 7
Julián Aragonés Lopez, Research Institute Princesa, Spain
Short Talk: Essential Role of the HIF1alpha Osygen-Sensing Pathway in Controlling Body Weight

Tuesday, February 14 | 8:00AM - 11:15AM
mTOR Signaling in Growth and Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 1 of 7
* Reuben J. Shaw, The Salk Institute for Biological Studies, USA


Tuesday, February 14 | 8:00AM - 11:15AM
mTOR Signaling in Growth and Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 2 of 7
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Regulation of Growth by the mTOR Pathway


Tuesday, February 14 | 8:00AM - 11:15AM
mTOR Signaling in Growth and Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 3 of 7
John Blenis, Weill Cornell Medical College, USA
mTOR Complex 1, Metabolism and Cell Growth Control


Tuesday, February 14 | 8:00AM - 11:15AM
mTOR Signaling in Growth and Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 4 of 7
Brendan D. Manning, Harvard School of Public Health, USA
mTOR Links Oncogenic Signaling to Tumor Cell Metabolism


Tuesday, February 14 | 8:00AM - 11:15AM
mTOR Signaling in Growth and Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 5 of 7
Kun-Liang Guan, University of California, San Diego, USA
Nutrient and mTOR Signals


Tuesday, February 14 | 8:00AM - 11:15AM
mTOR Signaling in Growth and Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 6 of 7
Camilla Norrmén, ETH Zurich, Switzerland
Short Talk: mTOR Signaling in Myelination of Peripheral Nerves


Tuesday, February 14 | 8:00AM - 11:15AM
mTOR Signaling in Growth and Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 7 of 7
David A. Guertin, University of Massachusetts Medical School, USA
Short Talk: Tissue Growth Control by PI3K-mTOR Signaling


Tuesday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Tuesday, February 14 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Tuesday, February 14 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, February 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Student/Postdoc Workshop
Room: Van Horne C

Speaker 1 of 9
* Pablo Wappner, Fundacion Instituto Leloir, Argentina

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Student/Postdoc Workshop
Room: Van Horne C

Speaker 2 of 9
Brooke M. Emerling, Sanford Burnham Prebys Medical Discovery Institute, USA
Identification of CDCP1 as a HIF-2alpha Target Gene Involved in the Regulation of Cancer Cell Migration and Metastasis

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Student/Postdoc Workshop
Room: Van Horne C

Speaker 3 of 9
Sofie Deschoemaeker, University of Leuven, Belgium
Gene-Targeting of PHD2 Oxygen Sensor Improved Tumor Response to Chemotherapy and Prevents Side-Toxicity in Mice

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Student/Postdoc Workshop
Room: Van Horne C

Speaker 4 of 9
Jung-whan Kim, University of Texas, USA
Deletion of Hypoxia Inducible Factor-1alpha (HIF-1alpha) In Stromal Fibroblasts Accelerates Mammary Tumor Progression through Vascular Normalization

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Student/Postdoc Workshop
Room: Van Horne C

Speaker 5 of 9
Muriel R. Kaufmann, University of Zürich, Switzerland
Presenilin Membrane Proteases as Novel Regulators of HIF via the APP/AICD Cleavage Cascade

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Student/Postdoc Workshop
Room: Van Horne C

Speaker 6 of 9
Pardeep Heir, University of Toronto, Canada
HIFalpha Binding to VHL Cues DCNL1 Recruitment to Trigger CUL2 Neddylation

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Student/Postdoc Workshop
Room: Van Horne C

Speaker 7 of 9
Kirsten Schneider, University Clinic Essen, Germany
Factor Inhibiting HIF-1 Modulates Protein Interactions of ASPP2

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Student/Postdoc Workshop
Room: Van Horne C

Speaker 8 of 9
Yukimi Sakoda, Yamaguchi University, Japan
Regulation of HIF-1alpha Erythropoiesis by HVEM

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Student/Postdoc Workshop
Room: Van Horne C

Speaker 9 of 9
Johannes Schödel, Universitätsklinikum Erlangen, Germany
Common Genetic Variants at the 11q13.3 Renal Cancer Susceptibility Locus Influence Binding of HIF to an Enhancer of Cyclin D1 Expression

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Cancer Metabolism I
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 1 of 9
* Lewis C. Cantley, Weill Cornell Medicine, USA


Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Cancer Metabolism I
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 2 of 9
Jessica J. Howell, Harvard School of Public Health, USA
Mechanisms and Consequences of mTORC1 Inhibition by Pharmacological Doses of Metformin


Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Cancer Metabolism I
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 3 of 9
Alfredo Csibi, Harvard Medical School, USA
The mTORC1 Pathway Regulates Glutamine Metabolism


Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Cancer Metabolism I
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 4 of 9
Peter Rahl, Massachusetts Institute of Technology, USA
c-Myc Overexpression Drives Binding to Distinct Enhancers in Different Cancers


Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Cancer Metabolism I
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 5 of 9
Kevin J. Williams, University of California, Los Angeles, USA
A Critical Role for SREBP1 in the Warburg Effect and Tumor Growth


Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Cancer Metabolism I
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 6 of 9
Kivanc Birsoy, Rockefeller University, USA
Use of Functional Genomic Screens and Nutrostats to Identify Metabolic Liabilities of Cancer Cells under Limiting Glucose and Oxygen Conditions


Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Cancer Metabolism I
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 7 of 9
Katharine V. Brown, University of California, Berkeley, USA
SIRT3 Regulates Hematopoeitic Stem Cell Aging


Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Cancer Metabolism I
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 8 of 9
Lluis Fajas, Université de Lausanne, Switzerland
Cdk4-E2F1 Mediate a Metabolic Switch in Normal and in Cancer Cells and Facilitate Whole Body Metabolic Adaptation to Cancer


Tuesday, February 14 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Cancer Metabolism I
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 9 of 9
Shi Chi Leow, ASTAR Singapore Institute for Clinical Sciences, Singapore
NF-kappaB Controls Energy Homeostasis and Metabolic Adaptation by Upregulating Mitochondrial Respiration


Tuesday, February 14 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, February 14 | 5:00PM - 7:00PM
Systemic Responses to Hypoxia and High Altitude
Room: Van Horne C

Speaker 1 of 5
* Josef Prchal, University of Utah, USA

Tuesday, February 14 | 5:00PM - 7:00PM
Systemic Responses to Hypoxia and High Altitude
Room: Van Horne C

Speaker 2 of 5
Max Gassmann, University of Zürich, Switzerland
Erythropoietin and Exercise Performance

Tuesday, February 14 | 5:00PM - 7:00PM
Systemic Responses to Hypoxia and High Altitude
Room: Van Horne C

Speaker 3 of 5
José López-Barneó, University of Seville, Spain
Contrasting Effects of Chronic Hypoxia on Central and Peripheral Neurogenic Centers

Tuesday, February 14 | 5:00PM - 7:00PM
Systemic Responses to Hypoxia and High Altitude
Room: Van Horne C

Speaker 4 of 5
Cynthia M. Beall, Case Western Reserve University, USA
Human Genetic Adaptation to High Altitude

Tuesday, February 14 | 5:00PM - 7:00PM
Systemic Responses to Hypoxia and High Altitude
Room: Van Horne C

Speaker 5 of 5
Donald A. McClain, University of Utah School of Medicine, USA
Short Talk: Metabolic Consequences of Genetic Adaptation to High Altitude in Tibetans

Tuesday, February 14 | 5:00PM - 7:00PM
Metabolic Stress Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 1 of 5
* Jared Rutter, University of Utah, USA


Tuesday, February 14 | 5:00PM - 7:00PM
Metabolic Stress Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 2 of 5
D. Grahame Hardie, University of Dundee, UK
AMPK – A Metabolic Master Switch Activated by Many Anti-Cancer Drugs


Tuesday, February 14 | 5:00PM - 7:00PM
Metabolic Stress Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 3 of 5
Reuben J. Shaw, The Salk Institute for Biological Studies, USA
LKB1 and AMPK Signaling in Cancer and Metabolism


Tuesday, February 14 | 5:00PM - 7:00PM
Metabolic Stress Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 4 of 5
Kevin Struhl, Harvard Medical School, USA
Anti-Cancer Effects of Metformin


Tuesday, February 14 | 5:00PM - 7:00PM
Metabolic Stress Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 5 of 5
Linda Z. Penn, Princess Margaret Cancer Centre, Canada
Short Talk: Targeting the Mevalonate Pathway in Cancer


Tuesday, February 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Tuesday, February 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Mezzanine 2


Wednesday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Wednesday, February 15 | 8:00AM - 11:15AM
Oxygen Signaling in Tissue Injury, Repair and Inflammation
Room: Van Horne C

Speaker 1 of 7
* Larrisa A. Shimoda, Johns Hopkins School of Medicine, USA

Wednesday, February 15 | 8:00AM - 11:15AM
Oxygen Signaling in Tissue Injury, Repair and Inflammation
Room: Van Horne C

Speaker 2 of 7
Bernhard Brüne, Goethe University Frankfurt, Germany
Oxygen-Dependent Regulation of Macrophage Function

Wednesday, February 15 | 8:00AM - 11:15AM
Oxygen Signaling in Tissue Injury, Repair and Inflammation
Room: Van Horne C

Speaker 3 of 7
Cormac Taylor, University College Dublin, Ireland
Hypoxia and Inflammation

Wednesday, February 15 | 8:00AM - 11:15AM
Oxygen Signaling in Tissue Injury, Repair and Inflammation
Room: Van Horne C

Speaker 4 of 7
Benoit Sebastien Marteyn, Institut Pasteur, France
Short Talk: Hypoxic Response during Pathogenic Enterobacterium Shigella Infection

Wednesday, February 15 | 8:00AM - 11:15AM
Oxygen Signaling in Tissue Injury, Repair and Inflammation
Room: Van Horne C

Speaker 5 of 7
Eric L. Campbell, UK
Short Talk: Transmigrating Neutrophils Induce “Transcriptional Imprinting” within the Epithelium and Reveals a Fundamental Role for Hypoxic Signaling Attributable to Localized Oxygen Depletion

Wednesday, February 15 | 8:00AM - 11:15AM
Oxygen Signaling in Tissue Injury, Repair and Inflammation
Room: Van Horne C

Speaker 6 of 7
Holger K. Eltzschig, University of Texas Health Science Center at Houston, USA
Hypoxia Responses in Acute Ischemia-Reperfusion Injury

Wednesday, February 15 | 8:00AM - 11:15AM
Oxygen Signaling in Tissue Injury, Repair and Inflammation
Room: Van Horne C

Speaker 7 of 7
Volker H. Haase, Vanderbilt University, USA
Tissue Responses to Chronic Hypoxia

Wednesday, February 15 | 8:00AM - 11:15AM
Connecting Metabolic Pathways to Growth Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 1 of 7
* Jeffrey C. Rathmell, Vanderbilt University, USA


Wednesday, February 15 | 8:00AM - 11:15AM
Connecting Metabolic Pathways to Growth Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 2 of 7
Jared Rutter, University of Utah, USA
Good and Bad Growth: The Virtues and Vices of Mitochondria and Metabolism


Wednesday, February 15 | 8:00AM - 11:15AM
Connecting Metabolic Pathways to Growth Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 3 of 7
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Regulation of Metabolic Pathways to Support Anabolic Metabolism


Wednesday, February 15 | 8:00AM - 11:15AM
Connecting Metabolic Pathways to Growth Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 4 of 7
Richard L. Possemato, New York University School of Medicine, USA
Short Talk: Identification of Metabolic Liabilities in Breast Cancer


Wednesday, February 15 | 8:00AM - 11:15AM
Connecting Metabolic Pathways to Growth Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 5 of 7
Heather Christofk, University of California, Los Angeles, USA
Short Talk: Role of MCT1 in Cancer Metabolism


Wednesday, February 15 | 8:00AM - 11:15AM
Connecting Metabolic Pathways to Growth Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 6 of 7
Andrew Mullen, University of Texas Southwestern Medical Center, USA
Short Talk: A Novel Pathway of Glutamine Metabolism Fuels Growth in Cancer Cells with Defective Mitochondria


Wednesday, February 15 | 8:00AM - 11:15AM
Connecting Metabolic Pathways to Growth Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 7 of 7
Christian Metallo, University of California, San Diego, USA
Short Talk: Reductive Tricarboxylic Acid Metabolism of Glutamine Mediates Lipogenesis under Hypoxia


Wednesday, February 15 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Wednesday, February 15 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Wednesday, February 15 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Wednesday, February 15 | 2:30PM - 4:30PM
Workshop 2: Technological Advances in Hypoxia Research
Room: Van Horne C

Speaker 1 of 8
* Frank S. Lee, University of Pennsylvania School of Medicine, USA

Wednesday, February 15 | 2:30PM - 4:30PM
Workshop 2: Technological Advances in Hypoxia Research
Room: Van Horne C

Speaker 2 of 8
David T. Eddington, University of Illinois, Chicago, USA
Microfluidic Oxygenated Substrates for Studying Ischemia Reperfusion and Intermittent Hypoxia

Wednesday, February 15 | 2:30PM - 4:30PM
Workshop 2: Technological Advances in Hypoxia Research
Room: Van Horne C

Speaker 3 of 8
Patrick R. Arsenault, University of Pennsylvania, USA
Effects of Mutations in Mouse Phd2 on Hematological and Physiological Phenotypes

Wednesday, February 15 | 2:30PM - 4:30PM
Workshop 2: Technological Advances in Hypoxia Research
Room: Van Horne C

Speaker 4 of 8
Analía Nuñez O´Mara, Center for Cooperative Research in Biosciences, Spain
The Role of SUMOylation in the Cellular Response to Hypoxia

Wednesday, February 15 | 2:30PM - 4:30PM
Workshop 2: Technological Advances in Hypoxia Research
Room: Van Horne C

Speaker 5 of 8
Violaine Sée, University of Liverpool, UK
Single Cell Imaging and Mathematical Modeling to Depict the Role of the Prolyl Hydroxylase-Negative Feedback Loop on HIF-1alpha Dynamics

Wednesday, February 15 | 2:30PM - 4:30PM
Workshop 2: Technological Advances in Hypoxia Research
Room: Van Horne C

Speaker 6 of 8
Othon Iliopoulos, Massachusetts General Hospital Cancer Center, USA
Regulation of Reductive TCA Cycle Metabolism by Hypoxia-HIF-VHL Signaling: New Opportunities for Therapy of Renal Cell Carcinoma

Wednesday, February 15 | 2:30PM - 4:30PM
Workshop 2: Technological Advances in Hypoxia Research
Room: Van Horne C

Speaker 7 of 8
Antonio Martinez-Ruiz, Hospital Santa Cristina, IIS Princesa, Spain
Differential Redox Proteomics Identify Proteins Reversibly Oxidized in Cysteines in Endothelial Cells in Response to Acute Hypoxia

Wednesday, February 15 | 2:30PM - 4:30PM
Workshop 2: Technological Advances in Hypoxia Research
Room: Van Horne C

Speaker 8 of 8
Ali Tavassoli, University of Southampton, UK
Inhibition of Hypoxia Signalling with Cyclic Peptide Inhibitors of HIF Heterodimerization

Wednesday, February 15 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, February 15 | 5:00PM - 7:00PM
Cellular Stress Responses to Hypoxia
Room: Van Horne C

Speaker 1 of 5
* Joachim Fandrey, University Duisburg-Essen, Germany

Wednesday, February 15 | 5:00PM - 7:00PM
Cellular Stress Responses to Hypoxia
Room: Van Horne C

Speaker 2 of 5
Paul T. Schumacker, Northwestern University, USA
Mitochondrial ROS Signaling under Hypoxic Stress

Wednesday, February 15 | 5:00PM - 7:00PM
Cellular Stress Responses to Hypoxia
Room: Van Horne C

Speaker 3 of 5
Ezra Burstein, University of Texas Southwestern Medical Center, USA
COMMD Proteins and Hypoxic Stress

Wednesday, February 15 | 5:00PM - 7:00PM
Cellular Stress Responses to Hypoxia
Room: Van Horne C

Speaker 4 of 5
Masayuki Yamamoto, Tohoku University Graduate School of Medicine, Japan
Hypoxia-Inducible and Tissue-Specific Erythropoietin Gene Regulation

Wednesday, February 15 | 5:00PM - 7:00PM
Cellular Stress Responses to Hypoxia
Room: Van Horne C

Speaker 5 of 5
Ho Jeong Kwon, Yonsei University, South Korea
Short Talk: Terpestacin and UQCRB, a New Small Molecule and its Target Protein in Hypoxia Signaling

Wednesday, February 15 | 5:00PM - 7:00PM
Lessons from Mouse Models
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 1 of 5
* Kay F. Macleod, University of Chicago, USA


Wednesday, February 15 | 5:00PM - 7:00PM
Lessons from Mouse Models
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 2 of 5
John L. Cleveland, The Scripps Research Institute, USA
Blocking Lactate Export by Inhibiting the Myc target Mct1 Disables Cancer Cell Metabolism and Impairs Tumorigenesis


Wednesday, February 15 | 5:00PM - 7:00PM
Lessons from Mouse Models
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 3 of 5
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Selective Autophagy and Oncogenesis


Wednesday, February 15 | 5:00PM - 7:00PM
Lessons from Mouse Models
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 4 of 5
Karen H. Vousden, Francis Crick Institute, UK
Control of Metabolism by the p53 Pathway


Wednesday, February 15 | 5:00PM - 7:00PM
Lessons from Mouse Models
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 5 of 5
Nada Y. Kalaany, Boston Children's Hospital at Harvard Medical School, USA
Short Talk: Adjacent Tumors Cohabiting the Same Tissue Respond Differentially to Dietary Restriction


Wednesday, February 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Wednesday, February 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Mezzanine 2


Thursday, February 16 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Thursday, February 16 | 8:00AM - 11:15AM
Therapeutic Targeting of Hypoxia Response Pathways
Room: Van Horne C

Speaker 1 of 7
* Roland H. Wenger, University of Zürich, Switzerland

Thursday, February 16 | 8:00AM - 11:15AM
Therapeutic Targeting of Hypoxia Response Pathways
Room: Van Horne C

Speaker 2 of 7
Michael H. Rabinowitz, Akebia Therapeutics, Inc., USA
Drug Development: Targeting Prolyl Hydroxylases

Thursday, February 16 | 8:00AM - 11:15AM
Therapeutic Targeting of Hypoxia Response Pathways
Room: Van Horne C

Speaker 3 of 7
Kai-Uwe Eckardt, University Clinic Erlangen, Germany
Clinical Application of Prolyl-Hydroxylase Inhibition

Thursday, February 16 | 8:00AM - 11:15AM
Therapeutic Targeting of Hypoxia Response Pathways
Room: Van Horne C

Speaker 4 of 7
Karen A. Vincent, Genzyme Corporation, USA
Cardiovascular Gene Therapy: Targeting Hypoxia

Thursday, February 16 | 8:00AM - 11:15AM
Therapeutic Targeting of Hypoxia Response Pathways
Room: Van Horne C

Speaker 5 of 7
Christian Stockmann, University of Zurich, Switzerland
Short Talk: Tuning Tumor Oxygenation and Reshaping the Tumor Microenvironment by Compartmentalized VEGF Expression - Impact on Tumor Relapse

Thursday, February 16 | 8:00AM - 11:15AM
Therapeutic Targeting of Hypoxia Response Pathways
Room: Van Horne C

Speaker 6 of 7
Mark W. Dewhirst, Duke University Medical Center, USA
Aerobic Exercise Training Decreases Tumor Growth Rates in Murine Models of Breast Cancer

Thursday, February 16 | 8:00AM - 11:15AM
Therapeutic Targeting of Hypoxia Response Pathways
Room: Van Horne C

Speaker 7 of 7
Alessio Ciulli, University of Dundee, School of Life Sciences, UK
Short Talk: Targeting the von Hippel-Lindau (pVHL) E3 Ubiquitin Ligase Multisubunit Protein Complex using Small Molecules to Disrupt its Interaction with Hypoxia Inducible Factor 1 alpha (Hif-1a)

Thursday, February 16 | 8:00AM - 11:15AM
Novel Mechanisms in Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 1 of 7
* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA


Thursday, February 16 | 8:00AM - 11:15AM
Novel Mechanisms in Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 2 of 7
Eyal Gottlieb, Technion - Israel Institute of Technology, Israel
The use of Metabolomics to Discover Novel Metabolic Networks and New Targets for Cancer Treatment


Thursday, February 16 | 8:00AM - 11:15AM
Novel Mechanisms in Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 3 of 7
Jeffrey C. Rathmell, Vanderbilt University, USA
Glucose Uptake and Metabolic Links to Cell Death


Thursday, February 16 | 8:00AM - 11:15AM
Novel Mechanisms in Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 4 of 7
Joan S. Brugge, Harvard Medical School, USA
Extracellular Matrix, Growth Factor and Oncogene Control of Cellular Survival and Metabolism


Thursday, February 16 | 8:00AM - 11:15AM
Novel Mechanisms in Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 5 of 7
Kay F. Macleod, University of Chicago, USA
Short Talk: BNip3 Limits HIF-1alpha Stabilization and Metastasis in a Mouse Model of Breast Cancer through Effects on Mitochondrial Integrity and ROS Generation


Thursday, February 16 | 8:00AM - 11:15AM
Novel Mechanisms in Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 6 of 7
Richard A. Cerione, Cornell University, USA
A New Way to Look at Cancer Signaling and Intervention


Thursday, February 16 | 8:00AM - 11:15AM
Novel Mechanisms in Metabolic Control
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 7 of 7
Gerald Hoefler, Medical University of Graz, Austria
Short Talk: Ablation of Triglyceride Lipases Protects from Cancer Associated Cachexia


Thursday, February 16 | 9:00AM - 9:20AM
Coffee Break
Room: Van Horne Foyer


Thursday, February 16 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, February 16 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Cancer Metabolism II
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 1 of 9
* Brendan D. Manning, Harvard School of Public Health, USA


Thursday, February 16 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Cancer Metabolism II
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 2 of 9
Cristina Muñoz-Pinedo, Institut d'Investigacio Biomedica de Bellvitge, Spain
Mechanisms of Tumor Cell Death Induced by Inhibition of Glucose Metabolism


Thursday, February 16 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Cancer Metabolism II
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 3 of 9
Patrick J. Pollard, University of Edinburgh, UK
Candidate Roles for Protein Succination in Altered Cellular Metabolism and Oncogenesis


Thursday, February 16 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Cancer Metabolism II
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 4 of 9
Charles Kung, Agios Pharmaceuticals Inc., USA
Induced Dependency on Amino Acid Metabolism in Proliferating Cancer Cells Upon PKM2 Activation


Thursday, February 16 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Cancer Metabolism II
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 5 of 9
William J. Israelsen, Massachusetts Institute of Technology, USA
Role of PKM2 in Tumor Development


Thursday, February 16 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Cancer Metabolism II
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 6 of 9
Patrick S. Ward, Massachusetts General Hospital, USA
Hypoxia Promotes IDH2-Dependent Carboxylation of alpha-Ketoglutarate to Citrate to Support Cell Growth and Viability


Thursday, February 16 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Cancer Metabolism II
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 7 of 9
David B. Shackelford, University of California, Los Angeles, USA
LKB1/STK11 Deficiency Sensitizes Genetically Engineered Mouse Models of Non Small Cell Lung Cancer to Phenformin Therapy


Thursday, February 16 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Cancer Metabolism II
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 8 of 9
Brandon Faubert, University of Texas Southwestern Medical Center, USA
The Energy Sensor AMP-activated Protein Kinase (AMPK) Mediates a Metabolic Switch to Warburg Metabolism in Cancer


Thursday, February 16 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Cancer Metabolism II
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 9 of 9
Robert E. Lewis, University of Nebraska Medical Center, USA
Coordinate Detection of New Targets and Small Molecules in Cancer Therapy


Thursday, February 16 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, February 16 | 5:00PM - 7:00PM
Hypoxic Signaling in Tumor Development and Progression
Room: Van Horne C

Speaker 1 of 5
* Thomas Kietzmann, University of Oulu, Finland

Thursday, February 16 | 5:00PM - 7:00PM
Hypoxic Signaling in Tumor Development and Progression
Room: Van Horne C

Speaker 2 of 5
Amato J. Giaccia, Stanford University, USA
Hypoxia and Metastasis

Thursday, February 16 | 5:00PM - 7:00PM
Hypoxic Signaling in Tumor Development and Progression
Room: Van Horne C

Speaker 3 of 5
Elizabeth Koch, Princess Margaret Hospital/Ontario Cancer Institute, Canada
Short Talk: Hypoxic Regulation of DICER1, microRNA, and their Influence on the Cancer Phenotype

Thursday, February 16 | 5:00PM - 7:00PM
Hypoxic Signaling in Tumor Development and Progression
Room: Van Horne C

Speaker 4 of 5
Margaret Ashcroft, University of Cambridge, UK
Mitochondrial Protein Regulators of Hypoxia Signaling and Tumour Progression

Thursday, February 16 | 5:00PM - 7:00PM
Hypoxic Signaling in Tumor Development and Progression
Room: Van Horne C

Speaker 5 of 5
Michael Ohh, University of Toronto, Canada
Non-Canonical Regulation of Gene Expression via HIF

Thursday, February 16 | 5:00PM - 7:00PM
Metabolic Drugs as Cancer Therapeutics
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 1 of 5
* David M. Sabatini, Whitehead Institute for Biomedical Research, USA


Thursday, February 16 | 5:00PM - 7:00PM
Metabolic Drugs as Cancer Therapeutics
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 2 of 5
Paul S. Mischel, University of California, San Diego, USA
Targeting Metabolic Pathways in EGFR-Activated Glioblastoma


Thursday, February 16 | 5:00PM - 7:00PM
Metabolic Drugs as Cancer Therapeutics
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 3 of 5
Kevin Marks, Agios Pharmaceuticals, USA
Targeting Metabolic Rewiring in Cancer


Thursday, February 16 | 5:00PM - 7:00PM
Metabolic Drugs as Cancer Therapeutics
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 4 of 5
Beat Nyfeler, Novartis Institutes for BioMedical Research, Switzerland
Targeting mTOR in Cancer


Thursday, February 16 | 5:00PM - 7:00PM
Metabolic Drugs as Cancer Therapeutics
This session is from Cancer and Metabolism
Room: Van Horne A-B

Speaker 5 of 5
Jonathan Mandelbaum, Accelerator Life Science Partners, USA
Short Talk: Generation of Chemical and Genetic Tools for Inhibiting ATG7 Function


Thursday, February 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Thursday, February 16 | 8:00PM - 11:00PM
Entertainment
Room: Mezzanine 2


Thursday, February 16 | 8:00PM - 11:00PM
Cash Bar
Room: Mezzanine 2


Friday, February 17 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.