Web Desc
ApoE, Alzheimer's and Lipoprotein Biology
joint with Clinical and Molecular Biology of Acute and Chronic Traumatic Encephalopathies
Organizer(s): Joachim Herz, David M. Holtzman and Eric M. Parker
Date: February 26 - March 02, 2012
Location: Keystone Resort, Keystone, CO, USA
Sponsored by AstraZeneca Pharmaceuticals, L.P., Biogen Idec and Merck & Co., Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
Apolipoprotein E4 (ApoE4) genotype is the primary risk factor for late-onset Alzheimer’s Disease. Approximately one fifth of the human population are ApoE4 carriers, yet more than 17 years after its discovery, the molecular basis by which this common allele causes neurodegeneration is still not understood. One major reason is the lack of effective communication between lipid researchers who have investigated the role of ApoE as a plasma lipid transport protein, and neuroscientists who are unfamiliar with the complex biochemistry of lipid metabolism and the cell biology of ApoE receptors. This is confounded by the methodological difficulty of studying lipid metabolism and lipoprotein transport in the brain and the paucity of pioneering work tackling this problem. Yet, the solution to one of the most pressing socioeconomic problems of our times, the looming Alzheimer’s Disease epidemic, depends on our ability to dissect and understand the molecular mechanism by which ApoE4 is causing this disease. The purpose of this highly interdisciplinary meeting on ApoE, Alzheimer’s and lipoprotein biology is to bring together a critical mass of experts with complementary expertise from these different fields, but who do not normally collaborate or attend the same conferences. In this manner, we envisage this meeting serving as the main catalyst for communication and collaboration between lipid and lipoprotein researchers, neurogeneticists, cell biologists and synaptic neurophysiologists. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent conference on Clinical and Molecular Biology of Acute and Chronic Traumatic Encephalopathies, which will share opening keynote addresses and a fourth day of sessions with this meeting.
Scholarship Deadline: October 26 2011
Discounted Abstract Deadline: October 26 2011
Abstract Deadline: December 2 2011
Discounted Registration Deadline: January 4 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZeneca Pharmaceuticals, L.P.Biogen IdecMerck & Co., Inc.
We gratefully acknowledge additional support for this conference from:
AlzheimerAvanti Polar Lipids, Inc.Boehringer Ingelheim StiftungLabome
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Avid Radiopharmaceuticals, Inc.

Eli Lilly and Company

Merck & Co., Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1R13AG041542-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 26 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, February 26 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak


Sunday, February 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Grays Peak

Speaker 1 of 5
* Joachim Herz, University of Texas Southwestern Medical Center, USA

Sunday, February 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Grays Peak

Speaker 2 of 5
* David M. Holtzman, Washington University, USA

Sunday, February 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Grays Peak

Speaker 3 of 5
* Eric M. Parker, Synergy Partners R&D Solutions, USA

Sunday, February 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Grays Peak

Speaker 4 of 5
Robert W. Mahley, J. David Gladstone Institutes, USA
Neurobiology of Apolipoprotein E in Alzheimer’s Disease and Traumatic Brain Injury

Sunday, February 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Grays Peak

Speaker 5 of 5
Robert C. Malenka, Stanford University School of Medicine, USA
Molecular Mechanisms of Synaptic Plasticity

Monday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
Room: Grays II & III

Speaker 1 of 7
* Robert W. Mahley, J. David Gladstone Institutes, USA

Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
Room: Grays II & III

Speaker 2 of 7
Yadong Huang, Gladstone Institutes/UCSF, USA
ApoE4 Structure–Related Detrimental Effects and Structure Correctors

Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
Room: Grays II & III

Speaker 3 of 7
Guojun Bu, Mayo Clinic, USA
ApoE Receptor LRP1 in Brain Lipid Metabolism, Synaptic Functions and Abeta Clearance

Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
Room: Grays II & III

Speaker 4 of 7
Carlos Cruchaga, Washington University School of Medicine, USA
What Do Genetic Studies Tell Us about the Role of APP and APOE in Risk for AD?

Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
Room: Grays II & III

Speaker 5 of 7
Eric Reiman, Banner Alzheimer's Institute, USA
Brain Imaging and ApoE4 in the Presymptomatic Study and Treatment of Alzheimer's Disease


Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
Room: Grays II & III

Speaker 6 of 7
Thomas L. Kukar, Emory University, USA
Short Talk: Lysine 624 of the Amyloid Precursor Protein (APP) is a Critical Determinant of Amyloid-beta Peptide Length

Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
Room: Grays II & III

Speaker 7 of 7
Huntington Potter, University of Colorado Denver, USA
Short Talk: Use of Parabiosis to Investigate the Role of Apolipoprotein E as Amyloid Catalyst and Peripheral Sink in Alzheimer’s Disease

Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 1 of 8
* Sam Gandy, Mount Sinai Medical Center, USA


Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 2 of 8
Steven T. DeKosky, University of Virginia, USA
Traumatic Brain Injury: Multiple Causes, and Short and Long-Term Consequences


Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 3 of 8
Andrew I. R. Maas, Antwerp University Hospital - UZA, Belgium
Definition and Epidemiology in TBI


Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 4 of 8
Kevin M. Guskiewicz, University of North Carolina, USA
Clinical Spectrum of Sports TBI


Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 5 of 8
Victoria E. Johnson, University of Pennsylvania, USA
Short Talk: Persistent Inflammation in the Corpus Callosum for Many Years following a Single TBI in Humans


Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 6 of 8
Jenna M. Ziebell, University of Arizona, USA
Short Talk: Morphological Alignment of Microglia across Cortical Layers after Experimental Diffuse Brain Injury


Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 7 of 8
Ramesh C. Nayak, MSDx Inc, USA
Short Talk: Recirculating Phagocytes are a Novel Source of Biomarkers for Brain Injury


Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 8 of 8
Sarah C. Hellewell, National Trauma Research Institute, Monash University, Australia
Short Talk: EPO Ameliorates Axonal Damage, Attenuates Macrophage Infiltration and Restores Motor Function in a Combined Model of TAI and Hypoxia


Monday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 27 | 11:15AM - 1:00PM
Poster Setup
Room: Longs Peak
Poster Set up for both sessions

Monday, February 27 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Monday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 27 | 5:00PM - 7:00PM
ApoE, APP and Tau - Physiology and Pathophysiology
Room: Grays II & III

Speaker 1 of 5
* Ryan J. Watts, Denali Therapeutics Inc, USA

Monday, February 27 | 5:00PM - 7:00PM
ApoE, APP and Tau - Physiology and Pathophysiology
Room: Grays II & III

Speaker 2 of 5
David M. Holtzman, Washington University, USA
ApoE and apoE Receptors: Influence on Abeta Metabolism

Monday, February 27 | 5:00PM - 7:00PM
ApoE, APP and Tau - Physiology and Pathophysiology
Room: Grays II & III

Speaker 3 of 5
Irene Knuesel, Roche Innovation Center Basel, Switzerland
Modulation of Amyloid and Tau Pathology by the ApoE Receptor Ligand, Reelin

Monday, February 27 | 5:00PM - 7:00PM
ApoE, APP and Tau - Physiology and Pathophysiology
Room: Grays II & III

Speaker 4 of 5
Jürgen M. Götz, University of Queensland, Australia
The Various Modes of Tau Toxicity

Monday, February 27 | 5:00PM - 7:00PM
ApoE, APP and Tau - Physiology and Pathophysiology
Room: Grays II & III

Speaker 5 of 5
Ina Caesar, Mount Sinai Medical Center, USA
Short Talk: Molecular Imaging of ApoE Isoform-Related Protein Conformation Changes in Human Alzheimer Brain

Monday, February 27 | 5:00PM - 7:00PM
Sports-Related TBI and CTE
This session is from Traumatic Brain Injury
Room: Grays I

Speaker 1 of 3
Thomas M. Talavage, Purdue University, USA
Neuroimaging of Concussive and Subconcussive Injury: Potential Clinical Application


Monday, February 27 | 5:00PM - 7:00PM
Sports-Related TBI and CTE
This session is from Traumatic Brain Injury
Room: Grays I

Speaker 2 of 3
* Jeffrey T. Barth, University of Virginia Health System, USA
Neuropsychological Assessment of Sports Concussion and CTE: From Dings to Dementia


Monday, February 27 | 5:00PM - 7:00PM
Sports-Related TBI and CTE
This session is from Traumatic Brain Injury
Room: Grays I

Speaker 3 of 3
Ann C. McKee, Boston University / VA Boston Healthcare System, USA
Molecular Neuropathology of Chronic Traumatic Encephalopathy and Encephalomyelopathy


Monday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Monday, February 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Longs Peak


Tuesday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature

Room: Grays II & III

Speaker 1 of 7
* David M. Holtzman, Washington University, USA

Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature

Room: Grays II & III

Speaker 2 of 7
Cheryl Wellington, University of British Columbia, Canada
From Concussion to Dementia: A Key Role for Apolipoprotein E

Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature

Room: Grays II & III

Speaker 3 of 7
Peter Tontonoz, University of California, Los Angeles, USA
Control of Brain Metabolism and LDLR Family Expression by LXRs

Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature

Room: Grays II & III

Speaker 4 of 7
Gary E. Landreth, Case Western Reserve University, USA
Retinoid X Receptors as Therapeutic Targets in Alzheimer's Disease

Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature

Room: Grays II & III

Speaker 5 of 7
Anders Nykjaer, Aarhus University, Denmark
Sortilins in Neuronal Plasticity and Degeneration

Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature

Room: Grays II & III

Speaker 6 of 7
Stephanie J. Soscia, Massachusetts General Hospital, USA
Short Talk: Analysis of the ABCA7 Transporter, Brain Lipids, and Alzheimer’s Disease

Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature

Room: Grays II & III

Speaker 7 of 7
Celina Zerbinatti, Merck Research Laboratories, USA
Short Talk: Cholesterol Ester Transfer Protein Deficient Polymorphisms Alter CSF Biomarkers and Reduce Alzheimer's Disease-Related Cognitive Impairment in Apolipoprotein E4 Carriers

Tuesday, February 28 | 8:00AM - 10:40AM
Classical Approaches to TBI: Metabolic and Axonal Dysfunctio
n
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 1 of 5
* Steven T. DeKosky, University of Virginia, USA


Tuesday, February 28 | 8:00AM - 10:40AM
Classical Approaches to TBI: Metabolic and Axonal Dysfunctio
n
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 2 of 5
Nick Tustison, University of Pennsylvania School of Medicine, USA
Understanding the Inside of the Black Box: Optimizing Approaches for the Analysis of Diffusion Tensor Imaging and Cortical Maps in TBI


Tuesday, February 28 | 8:00AM - 10:40AM
Classical Approaches to TBI: Metabolic and Axonal Dysfunctio
n
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 3 of 5
Stephen T. Ahlers, Naval Medical Research Center, USA
Considerations of Long-Term Sequalae in an Animal Model of Blast-Induced Mild Traumatic Brain Injury


Tuesday, February 28 | 8:00AM - 10:40AM
Classical Approaches to TBI: Metabolic and Axonal Dysfunctio
n
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 4 of 5
Sam Gandy, Mount Sinai Medical Center, USA
Novel Drugs Enhance Cognition and Stimulate Neurogenesis While Reducing Synaptic Generation of Abeta42


Tuesday, February 28 | 8:00AM - 10:40AM
Classical Approaches to TBI: Metabolic and Axonal Dysfunctio
n
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 5 of 5
Christopher Giza, University of California, Los Angeles, USA
Metabolism, Neural Activation and Plasticity after TBI: A Developmental Perspective


Tuesday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 28 | 10:40AM - 11:15AM
Molecular Biomarker Approach to TBI and CTE I
This session is from Traumatic Brain Injury
Room: Grays I

Speaker 1 of 2
Kaj Blennow, University of Gothenburg, Sweden
CSF Biomarkers of TBI


Tuesday, February 28 | 10:40AM - 11:15AM
Molecular Biomarker Approach to TBI and CTE I
This session is from Traumatic Brain Injury
Room: Grays I

Speaker 2 of 2
Theresa Currier Thomas, University of Kentucky, USA
Short Talk: Diffuse Brain Injury Causes Up-Regulation of Thrombospondins in the Rat Thalamus; Implications for a Role in Post-Traumatic Circuit Reorganization?


Tuesday, February 28 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, February 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Tuesday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 28 | 5:00PM - 7:00PM
Cell Biology and Development
Room: Grays II & III

Speaker 1 of 5
* Joachim Herz, University of Texas Southwestern Medical Center, USA

Tuesday, February 28 | 5:00PM - 7:00PM
Cell Biology and Development
Room: Grays II & III

Speaker 2 of 5
Steven J. Burden, New York University Medical Center, USA
An Lrp4-Centric View of Neuromuscular Synapse Formation

Tuesday, February 28 | 5:00PM - 7:00PM
Cell Biology and Development
Room: Grays II & III

Speaker 3 of 5
Weichun Lin, University of Texas Southwestern Medical Center, USA
Regulation of Synapse Formation and Maturation by ApoE Receptors and Amyloid Precursor Protein

Tuesday, February 28 | 5:00PM - 7:00PM
Cell Biology and Development
Room: Grays II & III

Speaker 4 of 5
Graham Collingridge, Lunenfeld-Tanenbaum Research Institute, Canada
Just Another Kinase Involved in Hippocampal Long-Term Depression: Implications for AD

Tuesday, February 28 | 5:00PM - 7:00PM
Cell Biology and Development
Room: Grays II & III

Speaker 5 of 5
Junichi Takagi, Osaka University, Japan
Short Talk: Structural Basis for Peptide Ligand Recognition by LR11/sorLA Vps10p Domain

Tuesday, February 28 | 5:00PM - 5:35PM
Molecular Biomarker Approach to TBI and CTE II
This session is from Traumatic Brain Injury
Room: Grays I

Speaker 1 of 2
* Ann C. McKee, Boston University / VA Boston Healthcare System, USA


Tuesday, February 28 | 5:00PM - 5:35PM
Molecular Biomarker Approach to TBI and CTE II
This session is from Traumatic Brain Injury
Room: Grays I

Speaker 2 of 2
Kevin K. W. Wang, University of Florida, McKnight Brain Institute, USA
Biomarkers for Traumatic Brain Injury, Potential Relevance to Chronic Traumatic Encephalopathy Development


Tuesday, February 28 | 5:35PM - 7:00PM
Animal Models of Blast TBI
This session is from Traumatic Brain Injury
Room: Grays I

Speaker 1 of 3
Kevin Kit Parker, Harvard University, USA
Integrin and Rho Signaling in Blast-Induced Brain Injury


Tuesday, February 28 | 5:35PM - 7:00PM
Animal Models of Blast TBI
This session is from Traumatic Brain Injury
Room: Grays I

Speaker 2 of 3
Lee E. Goldstein, Boston University, USA
Injury Mechanisms, Neuropathology, and Sequelae in a Murine Blast Neurotrauma Model


Tuesday, February 28 | 5:35PM - 7:00PM
Animal Models of Blast TBI
This session is from Traumatic Brain Injury
Room: Grays I

Speaker 3 of 3
Andrew R. Mayer, Mind Research Network, USA
Short Talk: Biomarkers of Increased Diffusion Anisotropy in Semi-Acute Mild Traumatic Brain Injury: A Longitudinal Perspective in Humans


Tuesday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Tuesday, February 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Longs Peak


Wednesday, February 29 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Wednesday, February 29 | 8:00AM - 11:00AM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport I

Room: Grays II & III

Speaker 1 of 6
* Eric M. Parker, Synergy Partners R&D Solutions, USA

Wednesday, February 29 | 8:00AM - 11:00AM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport I

Room: Grays II & III

Speaker 2 of 6
Ryan J. Watts, Denali Therapeutics Inc, USA
Are ApoE Receptors Viable 'Ski Lifts' to the Brain?

Wednesday, February 29 | 8:00AM - 11:00AM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport I

Room: Grays II & III

Speaker 3 of 6
Gabriella D'Arcangelo, Rutgers University, USA
Regulation of Dendritogenesis and Spine Formation by Reelin

Wednesday, February 29 | 8:00AM - 11:00AM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport I

Room: Grays II & III

Speaker 4 of 6
Joachim Herz, University of Texas Southwestern Medical Center, USA
A Molecular Basis for the Role of ApoE4 in Alzheimer’s Disease

Wednesday, February 29 | 8:00AM - 11:00AM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport I

Room: Grays II & III

Speaker 5 of 6
Steve W. Barger, University of Arkansas for Medical Sciences, USA
Short Talk: ApoE/Reelin Receptors are a Point of Convergence for Three Paths to Alzheimer’s Disease

Wednesday, February 29 | 8:00AM - 11:00AM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport I

Room: Grays II & III

Speaker 6 of 6
Justin Howard Trotter, University of South Florida Health, USA
Short Talk: Coordinated Regulation of Dab1 by Fyn and Cdk5

Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 1 of 8
* Lee E. Goldstein, Boston University, USA


Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 2 of 8
Kathryn E. Saatman, University of Kentucky, USA
The Calpain/Calpastatin System in TBI and Chronic Neurodegeneration


Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 3 of 8
David L. Brody, Washington University School of Medicine, USA
Changes in Amyloid Beta Protein Correlate with Neurological Status after TBI


Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 4 of 8
Douglas H. Smith, University of Pennsylvania, USA
TBI: Weapons of a Slow Killer


Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 5 of 8
David K. Menon, University of Cambridge, UK
Short Talk: PiB PET in TBI: Preliminary Results and Neuropathological Correlates


Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 6 of 8
Rachel Bennett, Massachusetts General Hospital, USA
Short Talk: Human Apolipoprotein E4 Accelerates Tau Pathology following TBI in 3xTg-AD Mice


Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 7 of 8
Andrei Irimia, University of California, Los Angeles, USA
Short Talk: Patient-Tailored Longitudinal Quantification of Brain Atrophy in Chronic Traumatic Encephalopathy using Multimodal Neuroimaging


Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 8 of 8
Linda J. Van Eldik, University of Kentucky, USA
Short Talk: A Novel Class of CNS Drugs Administered Hours Post-Injury Alters Pathology Progression and Improves Neurologic Outcomes in Closed Head Injury Models


Wednesday, February 29 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 29 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 29 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 29 | 5:00PM - 7:00PM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport II

Room: Grays II & III

Speaker 1 of 5
* Guojun Bu, Mayo Clinic, USA

Wednesday, February 29 | 5:00PM - 7:00PM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport II

Room: Grays II & III

Speaker 2 of 5
John R. Cirrito, Washington University, USA
Synaptic-Dependent Regulation of Abeta Metabolism and APP Processing in Vivo

Wednesday, February 29 | 5:00PM - 7:00PM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport II

Room: Grays II & III

Speaker 3 of 5
Jorge J. Palop, University of California, San Francisco, USA
Neuronal Rhythms, Network Hypersynchrony, and Cognitive Dysfunction in Alzheimer’s Disease

Wednesday, February 29 | 5:00PM - 7:00PM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport II

Room: Grays II & III

Speaker 4 of 5
Thomas E. Willnow, Max-Delbrueck-Center for Molecular Medicine, Germany
Role of SORLA/SORL1 in APP Sorting and Alzheimer's Disease

Wednesday, February 29 | 5:00PM - 7:00PM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport II

Room: Grays II & III

Speaker 5 of 5
Claus U. Pietrzik, University Medical Center of the Johannes Gutenberg-University, Germany
Short Talk: Genetic Evidence for LRP1 and PrPc Mediated Amyloid-beta Transcytosis Across the Blood-Brain Barrier

Wednesday, February 29 | 5:00PM - 7:00PM
Experimental Therapeutic Approaches to TBI/CTE Based on Insi
ghts from Recent Advances in Molecular Pathology of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 1 of 5
* Stephen T. Ahlers, Naval Medical Research Center, USA


Wednesday, February 29 | 5:00PM - 7:00PM
Experimental Therapeutic Approaches to TBI/CTE Based on Insi
ghts from Recent Advances in Molecular Pathology of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 2 of 5
Milos D. Ikonomovic, University of Pittsburgh, USA
Statin Therapy in Experimental TBI


Wednesday, February 29 | 5:00PM - 7:00PM
Experimental Therapeutic Approaches to TBI/CTE Based on Insi
ghts from Recent Advances in Molecular Pathology of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 3 of 5
Mark P. Burns, Georgetown University, USA
Gamma Secretase Inhibitor Therapy in Experimental TBI


Wednesday, February 29 | 5:00PM - 7:00PM
Experimental Therapeutic Approaches to TBI/CTE Based on Insi
ghts from Recent Advances in Molecular Pathology of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 4 of 5
Fernando Gomez-Pinilla, University of California at Los Angeles, USA
Diet and Exercise Therapy Against Brain Trauma


Wednesday, February 29 | 5:00PM - 7:00PM
Experimental Therapeutic Approaches to TBI/CTE Based on Insi
ghts from Recent Advances in Molecular Pathology of Neurodegenerative Diseases
This session is from Traumatic Brain Injury

Room: Grays I

Speaker 5 of 5
Effie Mitsis, James J. Peters VAMC, USA
Short Talk: Resting State Functional Connectivity in Blast-Related Mild Traumatic Brain Injury in OIF/OEF Combat Veterans with and without PTSD


Wednesday, February 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Thursday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Thursday, March 01 | 8:00AM - 11:00AM
Therapeutic and Diagnostic Approaches to Neurodegeneration a
nd Metabolism I (Joint)

Room: Grays Peak

Speaker 1 of 5
* Kelly R. Bales, F. Hoffmann-La Roche AG, Switzerland

Thursday, March 01 | 8:00AM - 11:00AM
Therapeutic and Diagnostic Approaches to Neurodegeneration a
nd Metabolism I (Joint)

Room: Grays Peak

Speaker 2 of 5
Eric M. Parker, Synergy Partners R&D Solutions, USA
Physiologic and Therapeutic Roles of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

Thursday, March 01 | 8:00AM - 11:00AM
Therapeutic and Diagnostic Approaches to Neurodegeneration a
nd Metabolism I (Joint)

Room: Grays Peak

Speaker 3 of 5
Edwin J. Weeber, University of South Florida, USA
Cognition Enhancement by ApoE Receptor Activators

Thursday, March 01 | 8:00AM - 11:00AM
Therapeutic and Diagnostic Approaches to Neurodegeneration a
nd Metabolism I (Joint)

Room: Grays Peak

Speaker 4 of 5
Michael P. Vitek, Duke University Medical Center and Cognosci, Inc., USA
Neuroprotective and Anti-Inflammatory Therapeutics for Traumatic Brain Injury and Alzheimer’s Disease Based Upon Apolipoprotein-E

Thursday, March 01 | 8:00AM - 11:00AM
Therapeutic and Diagnostic Approaches to Neurodegeneration a
nd Metabolism I (Joint)

Room: Grays Peak

Speaker 5 of 5
Mark A. Mintun, Avid Radiopharmaceuticals, Inc., USA
Interaction of Aging, ApoE Genotype and Amyloid Deposition as Revealed by Amyloid Imaging

Thursday, March 01 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 01 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 01 | 5:00PM - 7:00PM
Therapeutic and Diagnostic Approaches to Neurodegeneration a
nd Metabolism II (Joint)

Room: Grays Peak

Speaker 1 of 4
* Eric Reiman, Banner Alzheimer's Institute, USA

Thursday, March 01 | 5:00PM - 7:00PM
Therapeutic and Diagnostic Approaches to Neurodegeneration a
nd Metabolism II (Joint)

Room: Grays Peak

Speaker 2 of 4
Suzanne Craft, Wake Forest University School of Medicine, USA
Insulin Resistance and AD Pathology: Interactions with Apolipoprotein E

Thursday, March 01 | 5:00PM - 7:00PM
Therapeutic and Diagnostic Approaches to Neurodegeneration a
nd Metabolism II (Joint)

Room: Grays Peak

Speaker 3 of 4
Eric R. Siemers, Eli Lilly and Company, USA
Clinical Efficacy of Novel Amyloid-Lowering Therapies

Thursday, March 01 | 5:00PM - 7:00PM
Therapeutic and Diagnostic Approaches to Neurodegeneration a
nd Metabolism II (Joint)

Room: Grays Peak

Speaker 4 of 4
Kelly R. Bales, F. Hoffmann-La Roche AG, Switzerland
HDAC Inhibition: A Novel Pathway for Modulating Apolipoprotein E Levels

Thursday, March 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Thursday, March 01 | 8:00PM - 11:00PM
Entertainment
Room: Longs Peak


Thursday, March 01 | 8:00PM - 11:00PM
Cash Bar
Room: Longs Peak


Friday, March 02 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.