Web Desc
Clinical and Molecular Biology of Acute and Chronic Traumatic Encephalopathies
joint with ApoE, Alzheimer's and Lipoprotein Biology
Organizer(s): Sam Gandy, Steven T. DeKosky and Ann C. McKee
Date: February 26 - March 02, 2012
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
Acute traumatic brain injury (TBI) and its long-term neurodegenerative complications (known collectively as chronic traumatic encephalopathy, or CTE) are increasingly recognized as major public health issues, especially in the context of sports-related head injury and battlefield blast (military) exposure. Awareness of these issues has risen as neurological, psychiatric and neurodegenerative phenomena are associated with professional athletes and with veterans returning from Iraqi and Afghan theaters. The physics of head injury, as well as the epidemiological and neuropsychiatric aspects of sports-related and blast-related syndromes, will be reviewed in the initial sessions of this three-day meeting. Advances in functional neuroimaging and in the rapid and convenient determination of peptides and proteins in the cerebrospinal fluid and plasma will be reviewed in terms of their possible pathobiological significance as well as their identities as possible biomarkers. Later sessions will focus on the overlap between CTE and major neurodegenerative diseases, such as Alzheimer’s Disease (AD), frontotemporal dementia and amyotrophic lateral sclerosis. CTE is associated with accumulation of aggregated proteins or protein fragments, including tau, TDP-43, the Alzheimer’s amyloid precursor protein (APP) and the APP metabolite, amyloid-b. New experimental therapeutics research targets the roles these abnormal protein structures play in injury severity and subsequent outcome. Ab-lowering medications, currently in clinical trials for AD, improve outcome following acute brain trauma in rodent models, suggesting a pathway toward potential therapeutic interventions. Because apolipoprotein E (ApoE) isotype is an important determinant of outcome from acute severe as well as mild repetitive TBI, this meeting coincides in time and venue with the Keystone Symposia meeting on ApoE, Alzheimer’s and Lipoprotein Biology. Opening plenary sessions and an optional fourth day of sessions are available for those interested in learning more about basic biology and/or clinical interventions related to APOE.
Scholarship Deadline: October 26 2011
Discounted Abstract Deadline: October 26 2011
Abstract Deadline: December 2 2011
Discounted Registration Deadline: January 4 2012
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Avid Radiopharmaceuticals, Inc.

Eli Lilly and Company

Merck & Co., Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS077709-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 26 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, February 26 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak


Sunday, February 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Grays Peak

Speaker 1 of 5
* Joachim Herz, University of Texas Southwestern Medical Center, USA

Sunday, February 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Grays Peak

Speaker 2 of 5
* David M. Holtzman, Washington University, USA

Sunday, February 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Grays Peak

Speaker 3 of 5
* Eric M. Parker, Synergy Partners R&D Solutions, USA

Sunday, February 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Grays Peak

Speaker 4 of 5
Robert W. Mahley, J. David Gladstone Institutes, USA
Neurobiology of Apolipoprotein E in Alzheimer’s Disease and Traumatic Brain Injury

Sunday, February 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Grays Peak

Speaker 5 of 5
Robert C. Malenka, Stanford University School of Medicine, USA
Molecular Mechanisms of Synaptic Plasticity

Monday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Monday, February 27 | 8:00AM - 8:15AM
Welcoming Remarks
Room: Grays I

Speaker 1 of 3
* Sam Gandy, Mount Sinai Medical Center, USA

Monday, February 27 | 8:00AM - 8:15AM
Welcoming Remarks
Room: Grays I

Speaker 2 of 3
* Steven T. DeKosky, University of Virginia, USA

Monday, February 27 | 8:00AM - 8:15AM
Welcoming Remarks
Room: Grays I

Speaker 3 of 3
* Ann C. McKee, Boston University / VA Boston Healthcare System, USA

Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 1 of 7
* Robert W. Mahley, J. David Gladstone Institutes, USA


Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 2 of 7
Yadong Huang, Gladstone Institutes/UCSF, USA
ApoE4 Structure–Related Detrimental Effects and Structure Correctors


Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 3 of 7
Guojun Bu, Mayo Clinic, USA
ApoE Receptor LRP1 in Brain Lipid Metabolism, Synaptic Functions and Abeta Clearance


Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 4 of 7
Carlos Cruchaga, Washington University School of Medicine, USA
What Do Genetic Studies Tell Us about the Role of APP and APOE in Risk for AD?


Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 5 of 7
Eric Reiman, Banner Alzheimer's Institute, USA
Brain Imaging and ApoE4 in the Presymptomatic Study and Treatment of Alzheimer's Disease


Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 6 of 7
Thomas L. Kukar, Emory University, USA
Short Talk: Lysine 624 of the Amyloid Precursor Protein (APP) is a Critical Determinant of Amyloid-beta Peptide Length


Monday, February 27 | 8:00AM - 11:15AM
ApoE and ApoE Receptors - Structure, Function and Genetics
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 7 of 7
Huntington Potter, University of Colorado Denver, USA
Short Talk: Use of Parabiosis to Investigate the Role of Apolipoprotein E as Amyloid Catalyst and Peripheral Sink in Alzheimer’s Disease


Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI

Room: Grays I

Speaker 1 of 8
* Sam Gandy, Mount Sinai Medical Center, USA

Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI

Room: Grays I

Speaker 2 of 8
Steven T. DeKosky, University of Virginia, USA
Traumatic Brain Injury: Multiple Causes, and Short and Long-Term Consequences

Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI

Room: Grays I

Speaker 3 of 8
Andrew I. R. Maas, Antwerp University Hospital - UZA, Belgium
Definition and Epidemiology in TBI

Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI

Room: Grays I

Speaker 4 of 8
Kevin M. Guskiewicz, University of North Carolina, USA
Clinical Spectrum of Sports TBI

Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI

Room: Grays I

Speaker 5 of 8
Victoria E. Johnson, University of Pennsylvania, USA
Short Talk: Persistent Inflammation in the Corpus Callosum for Many Years following a Single TBI in Humans

Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI

Room: Grays I

Speaker 6 of 8
Jenna M. Ziebell, University of Arizona, USA
Short Talk: Morphological Alignment of Microglia across Cortical Layers after Experimental Diffuse Brain Injury

Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI

Room: Grays I

Speaker 7 of 8
Ramesh C. Nayak, MSDx Inc, USA
Short Talk: Recirculating Phagocytes are a Novel Source of Biomarkers for Brain Injury

Monday, February 27 | 8:15AM - 11:30AM
Definition of the Problem: Epidemiology of Sports and Milita
ry TBI

Room: Grays I

Speaker 8 of 8
Sarah C. Hellewell, National Trauma Research Institute, Monash University, Australia
Short Talk: EPO Ameliorates Axonal Damage, Attenuates Macrophage Infiltration and Restores Motor Function in a Combined Model of TAI and Hypoxia

Monday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 27 | 11:30AM - 1:00PM
Poster Setup
Room: Longs Peak


Monday, February 27 | 11:30AM - 11:30AM
On Own for Lunch and Recreation


Monday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Monday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 27 | 5:00PM - 7:00PM
Sports-Related TBI and CTE
Room: Grays I

Speaker 1 of 3
Thomas M. Talavage, Purdue University, USA
Neuroimaging of Concussive and Subconcussive Injury: Potential Clinical Application

Monday, February 27 | 5:00PM - 7:00PM
Sports-Related TBI and CTE
Room: Grays I

Speaker 2 of 3
* Jeffrey T. Barth, University of Virginia Health System, USA
Neuropsychological Assessment of Sports Concussion and CTE: From Dings to Dementia

Monday, February 27 | 5:00PM - 7:00PM
Sports-Related TBI and CTE
Room: Grays I

Speaker 3 of 3
Ann C. McKee, Boston University / VA Boston Healthcare System, USA
Molecular Neuropathology of Chronic Traumatic Encephalopathy and Encephalomyelopathy

Monday, February 27 | 5:00PM - 7:00PM
ApoE, APP and Tau - Physiology and Pathophysiology
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 1 of 5
* Ryan J. Watts, Denali Therapeutics Inc, USA


Monday, February 27 | 5:00PM - 7:00PM
ApoE, APP and Tau - Physiology and Pathophysiology
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 2 of 5
David M. Holtzman, Washington University, USA
ApoE and apoE Receptors: Influence on Abeta Metabolism


Monday, February 27 | 5:00PM - 7:00PM
ApoE, APP and Tau - Physiology and Pathophysiology
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 3 of 5
Irene Knuesel, Roche Innovation Center Basel, Switzerland
Modulation of Amyloid and Tau Pathology by the ApoE Receptor Ligand, Reelin


Monday, February 27 | 5:00PM - 7:00PM
ApoE, APP and Tau - Physiology and Pathophysiology
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 4 of 5
Jürgen M. Götz, University of Queensland, Australia
The Various Modes of Tau Toxicity


Monday, February 27 | 5:00PM - 7:00PM
ApoE, APP and Tau - Physiology and Pathophysiology
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 5 of 5
Ina Caesar, Mount Sinai Medical Center, USA
Short Talk: Molecular Imaging of ApoE Isoform-Related Protein Conformation Changes in Human Alzheimer Brain


Monday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Monday, February 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Longs Peak


Tuesday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Tuesday, February 28 | 8:00AM - 10:40AM
Classical Approaches to TBI: Metabolic and Axonal Dysfunctio
n

Room: Grays I

Speaker 1 of 5
* Steven T. DeKosky, University of Virginia, USA

Tuesday, February 28 | 8:00AM - 10:40AM
Classical Approaches to TBI: Metabolic and Axonal Dysfunctio
n

Room: Grays I

Speaker 2 of 5
Nick Tustison, University of Pennsylvania School of Medicine, USA
Understanding the Inside of the Black Box: Optimizing Approaches for the Analysis of Diffusion Tensor Imaging and Cortical Maps in TBI

Tuesday, February 28 | 8:00AM - 10:40AM
Classical Approaches to TBI: Metabolic and Axonal Dysfunctio
n

Room: Grays I

Speaker 3 of 5
Stephen T. Ahlers, Naval Medical Research Center, USA
Considerations of Long-Term Sequalae in an Animal Model of Blast-Induced Mild Traumatic Brain Injury

Tuesday, February 28 | 8:00AM - 10:40AM
Classical Approaches to TBI: Metabolic and Axonal Dysfunctio
n

Room: Grays I

Speaker 4 of 5
Sam Gandy, Mount Sinai Medical Center, USA
Novel Drugs Enhance Cognition and Stimulate Neurogenesis While Reducing Synaptic Generation of Abeta42

Tuesday, February 28 | 8:00AM - 10:40AM
Classical Approaches to TBI: Metabolic and Axonal Dysfunctio
n

Room: Grays I

Speaker 5 of 5
Christopher Giza, University of California, Los Angeles, USA
Metabolism, Neural Activation and Plasticity after TBI: A Developmental Perspective

Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 1 of 7
* David M. Holtzman, Washington University, USA


Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 2 of 7
Cheryl Wellington, University of British Columbia, Canada
From Concussion to Dementia: A Key Role for Apolipoprotein E


Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 3 of 7
Peter Tontonoz, University of California, Los Angeles, USA
Control of Brain Metabolism and LDLR Family Expression by LXRs


Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 4 of 7
Gary E. Landreth, Case Western Reserve University, USA
Retinoid X Receptors as Therapeutic Targets in Alzheimer's Disease


Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 5 of 7
Anders Nykjaer, Aarhus University, Denmark
Sortilins in Neuronal Plasticity and Degeneration


Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 6 of 7
Stephanie J. Soscia, Massachusetts General Hospital, USA
Short Talk: Analysis of the ABCA7 Transporter, Brain Lipids, and Alzheimer’s Disease


Tuesday, February 28 | 8:00AM - 11:15AM
Lipid Transport and Metabolism in the Brain and in the Vascu
lature
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 7 of 7
Celina Zerbinatti, Merck Research Laboratories, USA
Short Talk: Cholesterol Ester Transfer Protein Deficient Polymorphisms Alter CSF Biomarkers and Reduce Alzheimer's Disease-Related Cognitive Impairment in Apolipoprotein E4 Carriers


Tuesday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 28 | 10:40AM - 11:15AM
Molecular Biomarker Approach to TBI and CTE I
Room: Grays I

Speaker 1 of 2
Kaj Blennow, University of Gothenburg, Sweden
CSF Biomarkers of TBI

Tuesday, February 28 | 10:40AM - 11:15AM
Molecular Biomarker Approach to TBI and CTE I
Room: Grays I

Speaker 2 of 2
Theresa Currier Thomas, University of Kentucky, USA
Short Talk: Diffuse Brain Injury Causes Up-Regulation of Thrombospondins in the Rat Thalamus; Implications for a Role in Post-Traumatic Circuit Reorganization?

Tuesday, February 28 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, February 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Tuesday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 28 | 5:00PM - 5:35PM
Molecular Biomarker Approach to TBI and CTE II
Room: Grays I

Speaker 1 of 2
* Ann C. McKee, Boston University / VA Boston Healthcare System, USA

Tuesday, February 28 | 5:00PM - 5:35PM
Molecular Biomarker Approach to TBI and CTE II
Room: Grays I

Speaker 2 of 2
Kevin K. W. Wang, University of Florida, McKnight Brain Institute, USA
Biomarkers for Traumatic Brain Injury, Potential Relevance to Chronic Traumatic Encephalopathy Development

Tuesday, February 28 | 5:00PM - 7:00PM
Cell Biology and Development
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 1 of 5
* Joachim Herz, University of Texas Southwestern Medical Center, USA


Tuesday, February 28 | 5:00PM - 7:00PM
Cell Biology and Development
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 2 of 5
Steven J. Burden, New York University Medical Center, USA
An Lrp4-Centric View of Neuromuscular Synapse Formation


Tuesday, February 28 | 5:00PM - 7:00PM
Cell Biology and Development
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 3 of 5
Weichun Lin, University of Texas Southwestern Medical Center, USA
Regulation of Synapse Formation and Maturation by ApoE Receptors and Amyloid Precursor Protein


Tuesday, February 28 | 5:00PM - 7:00PM
Cell Biology and Development
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 4 of 5
Graham Collingridge, Lunenfeld-Tanenbaum Research Institute, Canada
Just Another Kinase Involved in Hippocampal Long-Term Depression: Implications for AD


Tuesday, February 28 | 5:00PM - 7:00PM
Cell Biology and Development
This session is from ApoE & Alzheimer's
Room: Grays II & III

Speaker 5 of 5
Junichi Takagi, Osaka University, Japan
Short Talk: Structural Basis for Peptide Ligand Recognition by LR11/sorLA Vps10p Domain


Tuesday, February 28 | 5:35PM - 7:00PM
Animal Models of Blast TBI
Room: Grays I

Speaker 1 of 3
Kevin Kit Parker, Harvard University, USA
Integrin and Rho Signaling in Blast-Induced Brain Injury

Tuesday, February 28 | 5:35PM - 7:00PM
Animal Models of Blast TBI
Room: Grays I

Speaker 2 of 3
Lee E. Goldstein, Boston University, USA
Injury Mechanisms, Neuropathology, and Sequelae in a Murine Blast Neurotrauma Model

Tuesday, February 28 | 5:35PM - 7:00PM
Animal Models of Blast TBI
Room: Grays I

Speaker 3 of 3
Andrew R. Mayer, Mind Research Network, USA
Short Talk: Biomarkers of Increased Diffusion Anisotropy in Semi-Acute Mild Traumatic Brain Injury: A Longitudinal Perspective in Humans

Tuesday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Tuesday, February 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Longs Peak


Wednesday, February 29 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases

Room: Grays I

Speaker 1 of 8
* Lee E. Goldstein, Boston University, USA

Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases

Room: Grays I

Speaker 2 of 8
Kathryn E. Saatman, University of Kentucky, USA
The Calpain/Calpastatin System in TBI and Chronic Neurodegeneration

Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases

Room: Grays I

Speaker 3 of 8
David L. Brody, Washington University School of Medicine, USA
Changes in Amyloid Beta Protein Correlate with Neurological Status after TBI

Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases

Room: Grays I

Speaker 4 of 8
Douglas H. Smith, University of Pennsylvania, USA
TBI: Weapons of a Slow Killer

Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases

Room: Grays I

Speaker 5 of 8
David K. Menon, University of Cambridge, UK
Short Talk: PiB PET in TBI: Preliminary Results and Neuropathological Correlates

Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases

Room: Grays I

Speaker 6 of 8
Rachel Bennett, Massachusetts General Hospital, USA
Short Talk: Human Apolipoprotein E4 Accelerates Tau Pathology following TBI in 3xTg-AD Mice

Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases

Room: Grays I

Speaker 7 of 8
Andrei Irimia, University of California, Los Angeles, USA
Short Talk: Patient-Tailored Longitudinal Quantification of Brain Atrophy in Chronic Traumatic Encephalopathy using Multimodal Neuroimaging

Wednesday, February 29 | 8:00AM - 11:00AM
Insights into CTE from Recent Advances in Molecular Patholog
y of Neurodegenerative Diseases

Room: Grays I

Speaker 8 of 8
Linda J. Van Eldik, University of Kentucky, USA
Short Talk: A Novel Class of CNS Drugs Administered Hours Post-Injury Alters Pathology Progression and Improves Neurologic Outcomes in Closed Head Injury Models

Wednesday, February 29 | 8:00AM - 11:00AM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport I
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 1 of 6
* Eric M. Parker, Synergy Partners R&D Solutions, USA


Wednesday, February 29 | 8:00AM - 11:00AM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport I
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 2 of 6
Ryan J. Watts, Denali Therapeutics Inc, USA
Are ApoE Receptors Viable 'Ski Lifts' to the Brain?


Wednesday, February 29 | 8:00AM - 11:00AM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport I
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 3 of 6
Gabriella D'Arcangelo, Rutgers University, USA
Regulation of Dendritogenesis and Spine Formation by Reelin


Wednesday, February 29 | 8:00AM - 11:00AM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport I
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 4 of 6
Joachim Herz, University of Texas Southwestern Medical Center, USA
A Molecular Basis for the Role of ApoE4 in Alzheimer’s Disease


Wednesday, February 29 | 8:00AM - 11:00AM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport I
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 5 of 6
Steve W. Barger, University of Arkansas for Medical Sciences, USA
Short Talk: ApoE/Reelin Receptors are a Point of Convergence for Three Paths to Alzheimer’s Disease


Wednesday, February 29 | 8:00AM - 11:00AM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport I
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 6 of 6
Justin Howard Trotter, University of South Florida Health, USA
Short Talk: Coordinated Regulation of Dab1 by Fyn and Cdk5


Wednesday, February 29 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 29 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 29 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 29 | 5:00PM - 7:00PM
Experimental Therapeutic Approaches to TBI/CTE Based on Insi
ghts from Recent Advances in Molecular Pathology of Neurodegenerative Diseases

Room: Grays I

Speaker 1 of 5
* Stephen T. Ahlers, Naval Medical Research Center, USA

Wednesday, February 29 | 5:00PM - 7:00PM
Experimental Therapeutic Approaches to TBI/CTE Based on Insi
ghts from Recent Advances in Molecular Pathology of Neurodegenerative Diseases

Room: Grays I

Speaker 2 of 5
Milos D. Ikonomovic, University of Pittsburgh, USA
Statin Therapy in Experimental TBI

Wednesday, February 29 | 5:00PM - 7:00PM
Experimental Therapeutic Approaches to TBI/CTE Based on Insi
ghts from Recent Advances in Molecular Pathology of Neurodegenerative Diseases

Room: Grays I

Speaker 3 of 5
Mark P. Burns, Georgetown University, USA
Gamma Secretase Inhibitor Therapy in Experimental TBI

Wednesday, February 29 | 5:00PM - 7:00PM
Experimental Therapeutic Approaches to TBI/CTE Based on Insi
ghts from Recent Advances in Molecular Pathology of Neurodegenerative Diseases

Room: Grays I

Speaker 4 of 5
Fernando Gomez-Pinilla, University of California at Los Angeles, USA
Diet and Exercise Therapy Against Brain Trauma

Wednesday, February 29 | 5:00PM - 7:00PM
Experimental Therapeutic Approaches to TBI/CTE Based on Insi
ghts from Recent Advances in Molecular Pathology of Neurodegenerative Diseases

Room: Grays I

Speaker 5 of 5
Effie Mitsis, James J. Peters VAMC, USA
Short Talk: Resting State Functional Connectivity in Blast-Related Mild Traumatic Brain Injury in OIF/OEF Combat Veterans with and without PTSD

Wednesday, February 29 | 5:00PM - 7:00PM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport II
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 1 of 5
* Guojun Bu, Mayo Clinic, USA


Wednesday, February 29 | 5:00PM - 7:00PM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport II
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 2 of 5
John R. Cirrito, Washington University, USA
Synaptic-Dependent Regulation of Abeta Metabolism and APP Processing in Vivo


Wednesday, February 29 | 5:00PM - 7:00PM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport II
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 3 of 5
Jorge J. Palop, University of California, San Francisco, USA
Neuronal Rhythms, Network Hypersynchrony, and Cognitive Dysfunction in Alzheimer’s Disease


Wednesday, February 29 | 5:00PM - 7:00PM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport II
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 4 of 5
Thomas E. Willnow, Max-Delbrueck-Center for Molecular Medicine, Germany
Role of SORLA/SORL1 in APP Sorting and Alzheimer's Disease


Wednesday, February 29 | 5:00PM - 7:00PM
ApoE, ApoE Receptors and Abeta - Synaptic Modulation, Proces
sing and Transport II
This session is from ApoE & Alzheimer's

Room: Grays II & III

Speaker 5 of 5
Claus U. Pietrzik, University Medical Center of the Johannes Gutenberg-University, Germany
Short Talk: Genetic Evidence for LRP1 and PrPc Mediated Amyloid-beta Transcytosis Across the Blood-Brain Barrier


Wednesday, February 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Thursday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Thursday, March 01 | 8:00AM - 11:00AM
ApoE and Alzheimer's Disease Session Open to both Meeting At
tendees. Therapeutic and Diagnostic Approaches to Neurodegeneration and Metabolism I (Joint)

Room: Grays Peak

Speaker 1 of 5
* Kelly R. Bales, F. Hoffmann-La Roche AG, Switzerland

Thursday, March 01 | 8:00AM - 11:00AM
ApoE and Alzheimer's Disease Session Open to both Meeting At
tendees. Therapeutic and Diagnostic Approaches to Neurodegeneration and Metabolism I (Joint)

Room: Grays Peak

Speaker 2 of 5
Eric M. Parker, Synergy Partners R&D Solutions, USA
Physiologic and Therapeutic Roles of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

Thursday, March 01 | 8:00AM - 11:00AM
ApoE and Alzheimer's Disease Session Open to both Meeting At
tendees. Therapeutic and Diagnostic Approaches to Neurodegeneration and Metabolism I (Joint)

Room: Grays Peak

Speaker 3 of 5
Edwin J. Weeber, University of South Florida, USA
Cognition Enhancement by ApoE Receptor Activators

Thursday, March 01 | 8:00AM - 11:00AM
ApoE and Alzheimer's Disease Session Open to both Meeting At
tendees. Therapeutic and Diagnostic Approaches to Neurodegeneration and Metabolism I (Joint)

Room: Grays Peak

Speaker 4 of 5
Michael P. Vitek, Duke University Medical Center and Cognosci, Inc., USA
Neuroprotective and Anti-Inflammatory Therapeutics for Traumatic Brain Injury and Alzheimer’s Disease Based Upon Apolipoprotein-E

Thursday, March 01 | 8:00AM - 11:00AM
ApoE and Alzheimer's Disease Session Open to both Meeting At
tendees. Therapeutic and Diagnostic Approaches to Neurodegeneration and Metabolism I (Joint)

Room: Grays Peak

Speaker 5 of 5
Mark A. Mintun, Avid Radiopharmaceuticals, Inc., USA
Interaction of Aging, ApoE Genotype and Amyloid Deposition as Revealed by Amyloid Imaging

Thursday, March 01 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 01 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 01 | 5:00PM - 7:00PM
ApoE and Alzheimer's Disease Session Open to both Meeting At
tendees. Therapeutic and Diagnostic Approaches to Neurodegeneration and Metabolism II (Joint)

Room: Grays Peak

Speaker 1 of 4
* Eric Reiman, Banner Alzheimer's Institute, USA

Thursday, March 01 | 5:00PM - 7:00PM
ApoE and Alzheimer's Disease Session Open to both Meeting At
tendees. Therapeutic and Diagnostic Approaches to Neurodegeneration and Metabolism II (Joint)

Room: Grays Peak

Speaker 2 of 4
Suzanne Craft, Wake Forest University School of Medicine, USA
Insulin Resistance and AD Pathology: Interactions with Apolipoprotein E

Thursday, March 01 | 5:00PM - 7:00PM
ApoE and Alzheimer's Disease Session Open to both Meeting At
tendees. Therapeutic and Diagnostic Approaches to Neurodegeneration and Metabolism II (Joint)

Room: Grays Peak

Speaker 3 of 4
Eric R. Siemers, Eli Lilly and Company, USA
Clinical Efficacy of Novel Amyloid-Lowering Therapies

Thursday, March 01 | 5:00PM - 7:00PM
ApoE and Alzheimer's Disease Session Open to both Meeting At
tendees. Therapeutic and Diagnostic Approaches to Neurodegeneration and Metabolism II (Joint)

Room: Grays Peak

Speaker 4 of 4
Kelly R. Bales, F. Hoffmann-La Roche AG, Switzerland
HDAC Inhibition: A Novel Pathway for Modulating Apolipoprotein E Levels

Thursday, March 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Thursday, March 01 | 8:00PM - 11:00PM
Entertainment
Room: Longs Peak


Thursday, March 01 | 8:00PM - 11:00PM
Cash Bar
Room: Longs Peak


Friday, March 02 | 10:25AM - 10:25AM
Departure


*Session Chair.