Web Desc
Innate Immunity: Sensing the Microbes and Damage Signals
joint with The Microbiome
Organizer(s): Gabriel Nuñez and Akiko Iwasaki
Date: March 04 - 09, 2012
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Gilead Sciences, Inc. Supported by an educational donation provided by Amgen.
For important information on the coronavirus, please click here
Summary of Meeting:
In recent years there have been major advances in our understanding of the mechanisms that are involved in the recognition of microbes and subsequent activation of host immune defenses. Several classes of membrane-bound and cytosolic pattern recognition receptors (PRRs) have been identified and partially characterized. These include the Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs). Activation of PRRs leads to the production of a large array of pro-inflammatory and anti-microbial molecules that are critical for the elimination of invading pathogens, and activation of adaptive immune responses. A class of cytosolic PRRs is involved in the assembly of the inflammasome, a molecular platform that mediates activation of caspase-1 and secretion of mature IL-1beta and IL-18. Importantly, activation of the inflammasome is also induced by non-microbial mechanisms including endogenous molecules involved in the pathogenesis of metabolic and inflammatory diseases. In addition, there is evidence that autophagy, a cellular process that mediates recycling of intracellular components, is involved in microbial recognition and plays a key role in host defense. The initial sensing of microbes often occurs at mucosal surfaces, but the interplay between recognition of commensal vs. pathogenic microbes on the host immune system is only beginning to be uncovered. The goal of the Keystone Symposia meeting on Innate Immunity: Sensing the Microbes and Damage Signals is to gather scientists working on innate immunity to discuss cutting edge research on the mechanisms that regulate the activation of the immune system by microbes as well as by endogenous damage signals, and to integrate such knowledge in the context of inflammation, homeostasis, host defense, and disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on The Microbiome, which will share a keynote address and three plenary sessions with this meeting.
Scholarship Deadline: November 3 2011
Discounted Abstract Deadline: November 3 2011
Abstract Deadline: December 8 2011
Discounted Registration Deadline: January 5 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Educational donation provided by AmgenGilead Sciences, Inc.
We gratefully acknowledge additional support for this conference from:
Biogen IdecLandes Bioscience
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Dynavax Technologies Corporation

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
EMBO (European Molecular Biology Organization)S. Karger AG - Journal of Innate Immunity
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI098256-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 04 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, March 04 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Sunday, March 04 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 1 of 2
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Damage Control in Host-Pathogen Interactions

Sunday, March 04 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 2 of 2
Jeffrey I. Gordon, Washington University School of Medicine, USA
Dining in with Trillions of Friends: Exploring the Human Gut Microbiome

Monday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak


Monday, March 05 | 8:00AM - 11:00AM
Inflammasome Activation by DAMPs and PAMPs
Room: Longs/Grays Peaks

Speaker 1 of 6
* Akiko Iwasaki, HHMI/Yale University School of Medicine, USA

Monday, March 05 | 8:00AM - 11:00AM
Inflammasome Activation by DAMPs and PAMPs
Room: Longs/Grays Peaks

Speaker 2 of 6
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
A Novel Inflammasome Pathway by Gram-Negative Bacteria

Monday, March 05 | 8:00AM - 11:00AM
Inflammasome Activation by DAMPs and PAMPs
Room: Longs/Grays Peaks

Speaker 3 of 6
Gabriel Nuñez, University of Michigan, USA
Sensing Microbes by the Inflammasome

Monday, March 05 | 8:00AM - 11:00AM
Inflammasome Activation by DAMPs and PAMPs
Room: Longs/Grays Peaks

Speaker 4 of 6
Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Regulation of Immune Pathways by the NLRs

Monday, March 05 | 8:00AM - 11:00AM
Inflammasome Activation by DAMPs and PAMPs
Room: Longs/Grays Peaks

Speaker 5 of 6
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs in Infection,Inflammation and Signaling

Monday, March 05 | 8:00AM - 11:00AM
Inflammasome Activation by DAMPs and PAMPs
Room: Longs/Grays Peaks

Speaker 6 of 6
Stephanie C. Eisenbarth, Yale University, USA
Short Talk: A Novel NLR Critical in the Initiation of Adaptive Immunity

Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
This session is from Microbiome
Room: Quandary Peak

Speaker 1 of 7
* Joseph F. Petrosino, Baylor College of Medicine, USA


Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
This session is from Microbiome
Room: Quandary Peak

Speaker 2 of 7
Ruth E. Ley, Max Planck Institute for Developmental Biology, Germany
Host Genetic Control of the Gut Microbiome


Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
This session is from Microbiome
Room: Quandary Peak

Speaker 3 of 7
Rob Knight, University of California, San Diego, USA
Defining an Aberrant Microbiota


Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
This session is from Microbiome
Room: Quandary Peak

Speaker 4 of 7
Forest Rohwer, San Diego State University, USA
The Human Virome


Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
This session is from Microbiome
Room: Quandary Peak

Speaker 5 of 7
Erwin G. Zoetendal, Wageningen University, Netherlands
Functional Metagenomics in the Gut


Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
This session is from Microbiome
Room: Quandary Peak

Speaker 6 of 7
Loreto Andrea Abusleme, NIDCR, National Institutes of Health, USA
Short Talk: The Relationship between Clinical Signs of Periodontal Destruction and Inflammation and the Subgingival Microbiome


Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
This session is from Microbiome
Room: Quandary Peak

Speaker 7 of 7
Kenny De Meirleir, University of Brussels, Belgium
Short Talk: Alterations of Intestinal Microflora in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients


Monday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 05 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys Peak


Monday, March 05 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Monday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Monday, March 05 | 2:30PM - 4:30PM
Workshop: Microbiota and Your Research: A How-to Guide to De
signing and Executing Studies of the Microbiota in Your Favorite Niche
This session is from Microbiome
Room: Quandary Peak

Speaker 1 of 1
* Ruth E. Ley, Max Planck Institute for Developmental Biology, Germany


Monday, March 05 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 05 | 5:00PM - 7:00PM
Viral Sensors and Defense Mechanisms
Room: Longs/Grays Peaks

Speaker 1 of 5
* Caetano Reis e Sousa, Francis Crick Institute, UK

Monday, March 05 | 5:00PM - 7:00PM
Viral Sensors and Defense Mechanisms
Room: Longs/Grays Peaks

Speaker 2 of 5
Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Antiviral Immunity at the Mucosal Surface

Monday, March 05 | 5:00PM - 7:00PM
Viral Sensors and Defense Mechanisms
Room: Longs/Grays Peaks

Speaker 3 of 5
Takashi Fujita, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan
Sensing Viral RNA in Cytoplasm and Activation of Antiviral Innate Immunity

Monday, March 05 | 5:00PM - 7:00PM
Viral Sensors and Defense Mechanisms
Room: Longs/Grays Peaks

Speaker 4 of 5
Michael S. Diamond, Washington University School of Medicine, USA
2'O Methylation of Viral RNA and Antagonism of an Interferon-Induced Antiviral Response

Monday, March 05 | 5:00PM - 7:00PM
Viral Sensors and Defense Mechanisms
Room: Longs/Grays Peaks

Speaker 5 of 5
Yorgo Modis, Yale University, USA
Short Talk: MDA5 Cooperatively Forms Dimers and ATP-Sensitive Filaments upon Binding Double-Stranded RNA

Monday, March 05 | 5:00PM - 7:00PM
Pathogen Microbiota Interactions
This session is from Microbiome
Room: Quandary Peak

Speaker 1 of 5
* Jorge A. Giron, Emerging Pathogens Institute, University of Florida, USA


Monday, March 05 | 5:00PM - 7:00PM
Pathogen Microbiota Interactions
This session is from Microbiome
Room: Quandary Peak

Speaker 2 of 5
Wendy S. Garrett, Harvard School of Public Health, USA
Disease-Associated and Beneficial Gut Microbiota in Colitis and Colorectal Cancer


Monday, March 05 | 5:00PM - 7:00PM
Pathogen Microbiota Interactions
This session is from Microbiome
Room: Quandary Peak

Speaker 3 of 5
Colin Hill, University College Cork, Ireland
Controlling Clostridium difficile without 'Collateral' Damage to the Microbiota


Monday, March 05 | 5:00PM - 7:00PM
Pathogen Microbiota Interactions
This session is from Microbiome
Room: Quandary Peak

Speaker 4 of 5
Natalia Shulzhenko, Oregon State University, USA
Microbiota and IgA: Keeping the Metabolism Up


Monday, March 05 | 5:00PM - 7:00PM
Pathogen Microbiota Interactions
This session is from Microbiome
Room: Quandary Peak

Speaker 5 of 5
Nobuhiko Kamada, University of Michigan, USA
Short Talk: Virulence Factor Expression Regulates the Interaction Between Enteric Pathogen and the Microbiota and Pathogen Eradication


Monday, March 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak


Monday, March 05 | 7:30PM - 10:00PM
Poster Session 1
Room: Torreys Peak


Tuesday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak


Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
Room: Longs/Grays Peaks

Speaker 1 of 7
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
Room: Longs/Grays Peaks

Speaker 2 of 7
Gregory M. Barton, University of California, Berkeley, USA
Regulation of Intracellular Toll-Like Receptors

Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
Room: Longs/Grays Peaks

Speaker 3 of 7
Jonathan C. Kagan, Boston Children's Hospital, USA
Cell Biology Aspect of Innate Immunity

Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
Room: Longs/Grays Peaks

Speaker 4 of 7
Michael Gale, Jr., University of Washington, USA
Control of RIG-I Signaling in RNA Virus Infection and Immunity

Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
Room: Longs/Grays Peaks

Speaker 5 of 7
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
MAVS – A Marvelous Mitochondrial Anti-Viral Signaling Protein

Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
Room: Longs/Grays Peaks

Speaker 6 of 7
Carolyn B. Coyne, University of Pittsburgh, USA
Short Talk: Focal Adhesion Kinase is a Component of RIG-I-like Receptor Antiviral Signaling

Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
Room: Longs/Grays Peaks

Speaker 7 of 7
T. Sam Xiao, Case Western Reserve University, USA
Short Talk: Mechanisms of DNA Recognition by the AIM2 and IFI16 Inflammasomes

Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
This session is from Microbiome
Room: Quandary Peak

Speaker 1 of 7
* Matam Vijay-Kumar, University of Toledo, USA


Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
This session is from Microbiome
Room: Quandary Peak

Speaker 2 of 7
Jeremy K. Nicholson, Imperial College London, UK
Systems Approaches to Investigate Host-Microbiota Metabolic Interactions


Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
This session is from Microbiome
Room: Quandary Peak

Speaker 3 of 7
Jens Walter, University of Alberta, Canada
Evolutionary Mechanisms That Shape Host-Microbiota Interactions and Their Consequences


Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
This session is from Microbiome
Room: Quandary Peak

Speaker 4 of 7
Thaddeus S. Stappenbeck, Cleveland Clinic, USA
Host-Microbe Interactions that Play a Role in the Pathogenesis of Inflammatory Bowel Disease


Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
This session is from Microbiome
Room: Quandary Peak

Speaker 5 of 7
Andrew T. Gewirtz, Georgia State University, USA
TLR5: Protecting the Gut from its BFF


Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
This session is from Microbiome
Room: Quandary Peak

Speaker 6 of 7
Christopher Power, University of Alberta, Canada
Short Talk: Human Brain Microbiome Diversity and Expression: alpha-Proteobacteria Predominate Independent of Host Immune Status


Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
This session is from Microbiome
Room: Quandary Peak

Speaker 7 of 7
Lara M. Bull-Otterson, Baylor College of Medicine, USA
Short Talk: A Preliminary Comparison of the Distal Gut Microbiome from HIV Infected before and after HAART


Tuesday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, March 06 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak


Tuesday, March 06 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress

Speaker 1 of 8
* Koichi S. Kobayashi, Texas A&M Health Science Center, USA

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress

Speaker 2 of 8
Fabianno F. Dutra, Universidade Federal do Rio de Janei, Institute of Microbiology, Brazil
Heme (Iron Protoporphyrin IX) Activates the NLRP3 Inflammasome

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress

Speaker 3 of 8
Jakob H. von Moltke, University of Washington, USA
A Novel Effector Function of the Inflammasome in vivo

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress

Speaker 4 of 8
Naeha Subramanian, Institute for Systems Biology, USA
Mitochondria Play a Central Role in NLRP3 Inflammasome Activation

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress

Speaker 5 of 8
Kenichi Shimada, Cedars-Sinai Medical Center, USA
Activation of the NLRP3 Inflammasome by Oxidized Mitochondrial DNA during Apoptosis

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress

Speaker 6 of 8
Saguna Verma, University of Hawaii at Manoa, USA
Inflammasome Sensor Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC) Restricts West Nile Virus (WNV) Infection and Spread to the Central Nervous System

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress

Speaker 7 of 8
Petr Broz, University of Lausanne, Switzerland
Canonical and Non-Canonical Inflammasomes Coordinate Host Response to Intracellular Salmonella typhimurium

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress

Speaker 8 of 8
Sammy Bedoui, University of Melbourne, Australia
NLRC4 Inflammasome Activation in Splenic Dendritic Cells Regulates Anti-Bacterial Effector Function by Memory CD8 T Cells

Tuesday, March 06 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, March 06 | 5:00PM - 7:00PM
Innate Immune Protection against Microbiota (Joint)
Room: Columbine Ballroom

Speaker 1 of 5
* Dan R. Littman, HHMI/New York University School of Medicine, USA

Tuesday, March 06 | 5:00PM - 7:00PM
Innate Immune Protection against Microbiota (Joint)
Room: Columbine Ballroom

Speaker 2 of 5
Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Immune Defense of the Intestinal Epithelial Surface

Tuesday, March 06 | 5:00PM - 7:00PM
Innate Immune Protection against Microbiota (Joint)
Room: Columbine Ballroom

Speaker 3 of 5
Gunnar C. Hansson, University of Gothenburg, Sweden
Good Barriers Encourage Appropriate Microbiota

Tuesday, March 06 | 5:00PM - 7:00PM
Innate Immune Protection against Microbiota (Joint)
Room: Columbine Ballroom

Speaker 4 of 5
Dana Philpott, University of Toronto, Canada
Sensing Bacterial Pathogens by NOD Proteins

Tuesday, March 06 | 5:00PM - 7:00PM
Innate Immune Protection against Microbiota (Joint)
Room: Columbine Ballroom

Speaker 5 of 5
Embriette Alicki, Baylor College of Medicine, USA
Short Talk: The Impact of IgA on the Intestinal Microbiome

Tuesday, March 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak


Tuesday, March 06 | 7:30PM - 10:00PM
Poster Session 2
Room: Torreys Peak


Wednesday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak


Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 1 of 7
* Lora V. Hooper, University of Texas Southwestern Medical Center, USA

Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 2 of 7
Andrew J.S. Macpherson, University of Bern, Switzerland
Immune Compartmentalisation in Mutualism with the Intestinal Microbiota

Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 3 of 7
Maria Rescigno, Humanitas University, Italy
Dendritic Cells in Host-Microbe Interactions in the Intestine

Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 4 of 7
Kiyoshi Takeda, Osaka University, Japan
Regulatory Mechanisms of Immune Responses to Intestinal Bacteria

Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 5 of 7
Sarkis K. Mazmanian, California Institute of Technology, USA
Learning to Tolerate our Microbial Self

Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 6 of 7
Gretchen E. Diehl, Baylor College of Medicine, USA
Short Talk: Commensals Limit Trafficking of Antigens from the Lamina Propria to the Mesenteric Lymph Nodes by CX3CR1+ Cells

Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 7 of 7
Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Short Talk: Lethal Inflammasome Activation by a Multi-Drug Resistant Pathobiont upon Antibiotic Disruption of the Microbiota

Wednesday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, March 07 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak


Wednesday, March 07 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, March 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses

Speaker 1 of 7
* Chris C. Norbury, Pennsylvania State University Medical School, USA

Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses

Speaker 2 of 7
Elina I. Zuniga, University of California, San Diego, USA
Regulation of Type I Interferon Production by Plasmacytoid Dendritic Cell

Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses

Speaker 3 of 7
Dmitry M. Shayakhmetov, Emory University, USA
Virus-Misplaced Host Protein Activates Innate Immunity

Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses

Speaker 4 of 7
Aaron R. Everitt, Wellcome Trust Sanger Institute, UK
IFITM3 Restricts the Morbidity and Mortality Associated with Influenza

Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses

Speaker 5 of 7
Gerard E. Kaiko, University of Newcastle, Australia
Early-Life Viral Infection and TLR7 Susceptibility Gene Interaction Predispose Toward the Development of Asthma in Later-Life

Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses

Speaker 6 of 7
Maulik Patel, Vanderbilt University, USA
Functional Dissection of MAVS Evolution

Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses

Speaker 7 of 7
Yayoi Izu, Pennsylvania State University, Milton S. Hershey College of Medicine, USA
Non-Classical Endocytosis Bypasses Early Endosomes To Deliver Mousepox Virions Directly to TLR9-Containing Lysosomes in Dendritic Cells, a Requisite Step in Protection from Lethal Infection

Wednesday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, March 07 | 5:00PM - 7:00PM
Lymphocyte-Microbiota Interactions (Joint)
Room: Columbine Ballroom

Speaker 1 of 5
* Ifor Williams, Science Immunology, USA

Wednesday, March 07 | 5:00PM - 7:00PM
Lymphocyte-Microbiota Interactions (Joint)
Room: Columbine Ballroom

Speaker 2 of 5
David Artis, Weill Cornell Medical College, USA
Microbial Regulation of Immune Cell Homeostasis

Wednesday, March 07 | 5:00PM - 7:00PM
Lymphocyte-Microbiota Interactions (Joint)
Room: Columbine Ballroom

Speaker 3 of 5
Dan R. Littman, HHMI/New York University School of Medicine, USA
Microbiota Regulation of Intestinal Lymphocytes

Wednesday, March 07 | 5:00PM - 7:00PM
Lymphocyte-Microbiota Interactions (Joint)
Room: Columbine Ballroom

Speaker 4 of 5
Kenya Honda, School of Medicine, Keio University, Japan
Intestinal Commensal Bacteria-Mediated Treg Induction

Wednesday, March 07 | 5:00PM - 7:00PM
Lymphocyte-Microbiota Interactions (Joint)
Room: Columbine Ballroom

Speaker 5 of 5
Timothy W. Hand, NIAID, National Institutes of Health, USA
Short Talk: Gastrointestinal Infection Induces Microbiota-Specific B and T Cell Responses

Wednesday, March 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak


Wednesday, March 07 | 7:30PM - 10:00PM
Poster Session 3
Room: Torreys Peak


Thursday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak


Thursday, March 08 | 8:00AM - 11:00AM
Pattern Recognition Receptors in Health and Disease
Room: Longs/Grays Peaks

Speaker 1 of 6
* Gabriel Nuñez, University of Michigan, USA

Thursday, March 08 | 8:00AM - 11:00AM
Pattern Recognition Receptors in Health and Disease
Room: Longs/Grays Peaks

Speaker 2 of 6
Robert L. Coffman, Dynavax Technologies, USA
Translating Innate Signals to Clinical Use

Thursday, March 08 | 8:00AM - 11:00AM
Pattern Recognition Receptors in Health and Disease
Room: Longs/Grays Peaks

Speaker 3 of 6
Herbert (Skip) W. Virgin, Vir Biotechnology, USA
Role of the Virome and Autophagy Proteins in Host Defense and Disease Susceptibility

Thursday, March 08 | 8:00AM - 11:00AM
Pattern Recognition Receptors in Health and Disease
Room: Longs/Grays Peaks

Speaker 4 of 6
Alan Sher, NIAID, National Institutes of Health, USA
Critical Role for Mincle/Card9 Signaling in the IL-1beta Dependent Th17 Polarizing Activity of Mycobacterial Adjuvant

Thursday, March 08 | 8:00AM - 11:00AM
Pattern Recognition Receptors in Health and Disease
Room: Longs/Grays Peaks

Speaker 5 of 6
Vishva M. Dixit, Genentech, Inc., USA
The Inflammasome: What Are the NOD Sensors Sensing?

Thursday, March 08 | 8:00AM - 11:00AM
Pattern Recognition Receptors in Health and Disease
Room: Longs/Grays Peaks

Speaker 6 of 6
Felix Yarovinsky, University of Rochester Medical Center, USA
Short Talk: B Cell-Intrinsic TLR Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage

Thursday, March 08 | 8:00AM - 11:00AM
Microbiota and Metabolism
This session is from Microbiome
Room: Quandary Peak

Speaker 1 of 6
* Jens Walter, University of Alberta, Canada


Thursday, March 08 | 8:00AM - 11:00AM
Microbiota and Metabolism
This session is from Microbiome
Room: Quandary Peak

Speaker 2 of 6
Fredrik Bäckhed, University of Gothenburg, Sweden
The Gut Microbiota as a Novel Modulator of Host Metabolism and Obesity


Thursday, March 08 | 8:00AM - 11:00AM
Microbiota and Metabolism
This session is from Microbiome
Room: Quandary Peak

Speaker 3 of 6
Patrice D. Cani, Université Catholique de Louvain, Belgium
Metabolic Endotoxemia Links Low-Grade Inflammation to Metabolic Diseases


Thursday, March 08 | 8:00AM - 11:00AM
Microbiota and Metabolism
This session is from Microbiome
Room: Quandary Peak

Speaker 4 of 6
Martin J. Blaser, New York University School of Medicine, USA
Animal Models of Microbe-Induced Obesity


Thursday, March 08 | 8:00AM - 11:00AM
Microbiota and Metabolism
This session is from Microbiome
Room: Quandary Peak

Speaker 5 of 6
Frederic D. Bushman, University of Pennsylvania, USA
Microbiome Dynamics: Diet and Disease


Thursday, March 08 | 8:00AM - 11:00AM
Microbiota and Metabolism
This session is from Microbiome
Room: Quandary Peak

Speaker 6 of 6
Eran Elinav, Weizmann Institute of Science, Israel
Short Talk: Nod-Like Receptor Proteins Regulate the Steady State and Mucosal Damage Response


Thursday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 08 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity

Speaker 1 of 7
* Ken Shortman, Walter and Eliza Hall Institute of Medical Research, Australia

Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity

Speaker 2 of 7
Carla V. Rothlin, Yale University, USA
T Cell-Derived Protein S Negatively Regulates the Innate Immune Response

Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity

Speaker 3 of 7
Alison N. Thorburn, Monash University, Australia
Bacterial Metabolite, Acetate, Suppresses Allergic Airways Disease

Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity

Speaker 4 of 7
Adriana R. Mantegazza, Children's Hospital of Philadelphia, USA
AP-3 is Required for Phagosome-Intrinsic TLR Signaling and Subsequent MHC-II Presentation in Dendritic Cells

Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity

Speaker 5 of 7
Ty D. Troutman, University of California, San Diego, USA
BCAP is a TIR-Domain Containing Signaling Adaptor Linking TLRs to PI3K/AKT

Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity

Speaker 6 of 7
Malin E. V. Johansson, University of Gothenburg, Sweden
Mucus Barrier Defects are Associated with Intestinal Inflammation both in Murine Spontaneous Colitis Models and Patients with Ulcerative Colitis

Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity

Speaker 7 of 7
Iliyan D. Iliev, Weill-Cornell Medical College, USA
Dectin-1 Mediated Mucosal Immunity to Commensal Fungi Influences Colitis

Thursday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 08 | 5:00PM - 7:00PM
Recognition of Cell Death and Immunity
Room: Longs/Grays Peaks

Speaker 1 of 5
* Gregory M. Barton, University of California, Berkeley, USA

Thursday, March 08 | 5:00PM - 7:00PM
Recognition of Cell Death and Immunity
Room: Longs/Grays Peaks

Speaker 2 of 5
Caetano Reis e Sousa, Francis Crick Institute, UK
Recognition of Cell Death and Adaptive Immunity

Thursday, March 08 | 5:00PM - 7:00PM
Recognition of Cell Death and Immunity
Room: Longs/Grays Peaks

Speaker 3 of 5
Rhea M. Sumpter, Jr., University of Texas Southwestern Medical Center, USA

Thursday, March 08 | 5:00PM - 7:00PM
Recognition of Cell Death and Immunity
Room: Longs/Grays Peaks

Speaker 4 of 5
Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Infection and Apoptosis as a Combined Inflammatory Trigger

Thursday, March 08 | 5:00PM - 7:00PM
Recognition of Cell Death and Immunity
Room: Longs/Grays Peaks

Speaker 5 of 5
Thomas Gajewski, University of Chicago, USA
Short Talk: Innate Immune Sensing of Tumors is Driven by a Cytosolic DNA Sensing/STING Pathway that Induces Host IFN-beta Production and DC Activation

Thursday, March 08 | 5:00PM - 7:00PM
Therapeutic Manipulation of Microbiota
This session is from Microbiome
Room: Quandary Peak

Speaker 1 of 5
* Alexander Khoruts, University of Minnesota, USA


Thursday, March 08 | 5:00PM - 7:00PM
Therapeutic Manipulation of Microbiota
This session is from Microbiome
Room: Quandary Peak

Speaker 2 of 5
Fergus Shanahan, National University of Ireland, Ireland
Making Peace: Altering Host-Microbiota Relationship in Chronic Gut Inflammation


Thursday, March 08 | 5:00PM - 7:00PM
Therapeutic Manipulation of Microbiota
This session is from Microbiome
Room: Quandary Peak

Speaker 3 of 5
Philip M. Sherman, Hospital for Sick Children, University of Toronto, Canada
Altering the Pediatric Intestinal Microbiota


Thursday, March 08 | 5:00PM - 7:00PM
Therapeutic Manipulation of Microbiota
This session is from Microbiome
Room: Quandary Peak

Speaker 4 of 5
James Versalovic, Texas Children's Hospital, USA
Defining Microbial Disease Signatures in Pediatric Gut Microbiomes – and Microbial Modification Strategies as Therapies


Thursday, March 08 | 5:00PM - 7:00PM
Therapeutic Manipulation of Microbiota
This session is from Microbiome
Room: Quandary Peak

Speaker 5 of 5
Marie-Christine Simon, University of Bonn, Germany
Short Talk: Probiotics as a Novel Approach to Modulate Gut Hormone Secretion and Insulin Sensitivity and Secretion


Thursday, March 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak


Thursday, March 08 | 8:00PM - 11:00PM
Entertainment
Room: Torreys Peak


Thursday, March 08 | 8:00PM - 11:00PM
Cash Bar
Room: Torreys Peak


Friday, March 09 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.