Web Desc
The Microbiome
joint with Innate Immunity: Sensing the Microbes and Damage Signals
Organizer(s): Andrew T. Gewirtz, Fergus Shanahan and Ruth E. Ley
Date: March 04 - 09, 2012
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
Emerging themes from several traditionally disparate areas of research have begun to coalesce around the concept that the complex microbial communities that inhabit most external human surfaces play a key role in health and disease. Specifically, processes including basic immune system development, host-pathogen interactions, metabolic disease and cancer are all greatly influenced by the composition and bioactivity of the microbiota that live within us. Understanding how mammalian hosts regulate their microbiota and the myriad of ways by which the microbiota can alter susceptibility to a wide range of diseases is a key opportunity to better understand numerous diseases and, subsequently, provide strategies to promote human health. Thus, the goal of the Keystone Symposia meeting on The Microbiome is to facilitate the understanding of mechanisms that maintain a healthy host-microbiota relationship and explore how perturbations in this relationship increase susceptibility to a variety of diseases, especially those associated with chronic inflammation. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Innate Immunity: Sensing the Microbes and Damage Signals, which will share a keynote address and three plenary sessions with this meeting.
Scholarship Deadline: November 3 2011
Discounted Abstract Deadline: November 3 2011
Abstract Deadline: December 8 2011
Discounted Registration Deadline: January 5 2012
We gratefully acknowledge additional support for this conference from:
Biogen IdecCubist Pharmaceuticals, Inc.JDRF
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI098352-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 04 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, March 04 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Sunday, March 04 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 1 of 2
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Damage Control in Host-Pathogen Interactions

Sunday, March 04 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 2 of 2
Jeffrey I. Gordon, Washington University School of Medicine, USA
Dining in with Trillions of Friends: Exploring the Human Gut Microbiome

Monday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak


Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
Room: Quandary Peak

Speaker 1 of 7
* Joseph F. Petrosino, Baylor College of Medicine, USA

Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
Room: Quandary Peak

Speaker 2 of 7
Ruth E. Ley, Max Planck Institute for Developmental Biology, Germany
Host Genetic Control of the Gut Microbiome

Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
Room: Quandary Peak

Speaker 3 of 7
Rob Knight, University of California, San Diego, USA
Defining an Aberrant Microbiota

Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
Room: Quandary Peak

Speaker 4 of 7
Forest Rohwer, San Diego State University, USA
The Human Virome

Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
Room: Quandary Peak

Speaker 5 of 7
Erwin G. Zoetendal, Wageningen University, Netherlands
Functional Metagenomics in the Gut

Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
Room: Quandary Peak

Speaker 6 of 7
Loreto Andrea Abusleme, NIDCR, National Institutes of Health, USA
Short Talk: The Relationship between Clinical Signs of Periodontal Destruction and Inflammation and the Subgingival Microbiome

Monday, March 05 | 8:00AM - 11:15AM
Defining the Normal and Aberrant Microbiotas
Room: Quandary Peak

Speaker 7 of 7
Kenny De Meirleir, University of Brussels, Belgium
Short Talk: Alterations of Intestinal Microflora in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Monday, March 05 | 8:00AM - 11:00AM
Inflammasome Activation by DAMPs and PAMPs
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 1 of 6
* Akiko Iwasaki, HHMI/Yale University School of Medicine, USA


Monday, March 05 | 8:00AM - 11:00AM
Inflammasome Activation by DAMPs and PAMPs
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 2 of 6
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
A Novel Inflammasome Pathway by Gram-Negative Bacteria


Monday, March 05 | 8:00AM - 11:00AM
Inflammasome Activation by DAMPs and PAMPs
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 3 of 6
Gabriel Nuñez, University of Michigan, USA
Sensing Microbes by the Inflammasome


Monday, March 05 | 8:00AM - 11:00AM
Inflammasome Activation by DAMPs and PAMPs
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 4 of 6
Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Regulation of Immune Pathways by the NLRs


Monday, March 05 | 8:00AM - 11:00AM
Inflammasome Activation by DAMPs and PAMPs
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 5 of 6
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs in Infection,Inflammation and Signaling


Monday, March 05 | 8:00AM - 11:00AM
Inflammasome Activation by DAMPs and PAMPs
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 6 of 6
Stephanie C. Eisenbarth, Yale University, USA
Short Talk: A Novel NLR Critical in the Initiation of Adaptive Immunity


Monday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 05 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak


Monday, March 05 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Monday, March 05 | 2:30PM - 4:30PM
Workshop: Microbiota and Your Research: A How-to Guide to De
signing and Executing Studies of the Microbiota in Your Favorite Niche
Room: Quandary Peak

Speaker 1 of 1
* Ruth E. Ley, Max Planck Institute for Developmental Biology, Germany

Monday, March 05 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 05 | 5:00PM - 7:00PM
Viral Sensors and Defense Mechanisms
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 1 of 5
* Caetano Reis e Sousa, Francis Crick Institute, UK


Monday, March 05 | 5:00PM - 7:00PM
Viral Sensors and Defense Mechanisms
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 2 of 5
Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Antiviral Immunity at the Mucosal Surface


Monday, March 05 | 5:00PM - 7:00PM
Viral Sensors and Defense Mechanisms
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 3 of 5
Takashi Fujita, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan
Sensing Viral RNA in Cytoplasm and Activation of Antiviral Innate Immunity


Monday, March 05 | 5:00PM - 7:00PM
Viral Sensors and Defense Mechanisms
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 4 of 5
Michael S. Diamond, Washington University School of Medicine, USA
2'O Methylation of Viral RNA and Antagonism of an Interferon-Induced Antiviral Response


Monday, March 05 | 5:00PM - 7:00PM
Viral Sensors and Defense Mechanisms
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 5 of 5
Yorgo Modis, Yale University, USA
Short Talk: MDA5 Cooperatively Forms Dimers and ATP-Sensitive Filaments upon Binding Double-Stranded RNA


Monday, March 05 | 5:00PM - 7:00PM
Pathogen Microbiota Interactions
Room: Quandary Peak

Speaker 1 of 5
* Jorge A. Giron, Emerging Pathogens Institute, University of Florida, USA

Monday, March 05 | 5:00PM - 7:00PM
Pathogen Microbiota Interactions
Room: Quandary Peak

Speaker 2 of 5
Wendy S. Garrett, Harvard School of Public Health, USA
Disease-Associated and Beneficial Gut Microbiota in Colitis and Colorectal Cancer

Monday, March 05 | 5:00PM - 7:00PM
Pathogen Microbiota Interactions
Room: Quandary Peak

Speaker 3 of 5
Colin Hill, University College Cork, Ireland
Controlling Clostridium difficile without 'Collateral' Damage to the Microbiota

Monday, March 05 | 5:00PM - 7:00PM
Pathogen Microbiota Interactions
Room: Quandary Peak

Speaker 4 of 5
Natalia Shulzhenko, Oregon State University, USA
Microbiota and IgA: Keeping the Metabolism Up

Monday, March 05 | 5:00PM - 7:00PM
Pathogen Microbiota Interactions
Room: Quandary Peak

Speaker 5 of 5
Nobuhiko Kamada, University of Michigan, USA
Short Talk: Virulence Factor Expression Regulates the Interaction Between Enteric Pathogen and the Microbiota and Pathogen Eradication

Monday, March 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak


Monday, March 05 | 7:30PM - 10:00PM
Poster Session 1
Room: Torreys Peak


Tuesday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak


Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
Room: Quandary Peak

Speaker 1 of 7
* Matam Vijay-Kumar, University of Toledo, USA

Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
Room: Quandary Peak

Speaker 2 of 7
Jeremy K. Nicholson, Imperial College London, UK
Systems Approaches to Investigate Host-Microbiota Metabolic Interactions

Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
Room: Quandary Peak

Speaker 3 of 7
Jens Walter, APC Microbiome Ireland. University College Cork, Ireland
Evolutionary Mechanisms That Shape Host-Microbiota Interactions and Their Consequences

Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
Room: Quandary Peak

Speaker 4 of 7
Thaddeus S. Stappenbeck, Cleveland Clinic, USA
Host-Microbe Interactions that Play a Role in the Pathogenesis of Inflammatory Bowel Disease

Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
Room: Quandary Peak

Speaker 5 of 7
Andrew T. Gewirtz, Georgia State University / Frontiers, USA
TLR5: Protecting the Gut from its BFF

Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
Room: Quandary Peak

Speaker 6 of 7
Christopher Power, University of Alberta, Canada
Short Talk: Human Brain Microbiome Diversity and Expression: alpha-Proteobacteria Predominate Independent of Host Immune Status

Tuesday, March 06 | 8:00AM - 11:15AM
Complexity in Microbiota Host Interactions
Room: Quandary Peak

Speaker 7 of 7
Lara M. Bull-Otterson, Baylor College of Medicine, USA
Short Talk: A Preliminary Comparison of the Distal Gut Microbiome from HIV Infected before and after HAART

Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 1 of 7
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA


Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 2 of 7
Gregory M. Barton, University of California, Berkeley, USA
Regulation of Intracellular Toll-Like Receptors


Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 3 of 7
Jonathan C. Kagan, Boston Children's Hospital, USA
Cell Biology Aspect of Innate Immunity


Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 4 of 7
Michael Gale, Jr., University of Washington, USA
Control of RIG-I Signaling in RNA Virus Infection and Immunity


Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 5 of 7
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
MAVS – A Marvelous Mitochondrial Anti-Viral Signaling Protein


Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 6 of 7
Carolyn B. Coyne, University of Pittsburgh, USA
Short Talk: Focal Adhesion Kinase is a Component of RIG-I-like Receptor Antiviral Signaling


Tuesday, March 06 | 8:00AM - 11:15AM
Pattern Recognition Receptor Trafficking and Signaling
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 7 of 7
Tsan Sam Xiao, Case Western Reserve University, USA
Short Talk: Mechanisms of DNA Recognition by the AIM2 and IFI16 Inflammasomes


Tuesday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, March 06 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak


Tuesday, March 06 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress
This session is from Innate Immunity

Speaker 1 of 8
* Koichi S. Kobayashi, Texas A&M Health Science Center, USA


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress
This session is from Innate Immunity

Speaker 2 of 8
Fabianno F. Dutra, Universidade Federal do Rio de Janei, Institute of Microbiology, Brazil
Heme (Iron Protoporphyrin IX) Activates the NLRP3 Inflammasome


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress
This session is from Innate Immunity

Speaker 3 of 8
Jakob H. von Moltke, University of Washington, USA
A Novel Effector Function of the Inflammasome in vivo


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress
This session is from Innate Immunity

Speaker 4 of 8
Naeha Subramanian, Institute for Systems Biology, USA
Mitochondria Play a Central Role in NLRP3 Inflammasome Activation


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress
This session is from Innate Immunity

Speaker 5 of 8
Kenichi Shimada, Cedars-Sinai Medical Center, USA
Activation of the NLRP3 Inflammasome by Oxidized Mitochondrial DNA during Apoptosis


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress
This session is from Innate Immunity

Speaker 6 of 8
Saguna Verma, University of Hawaii at Manoa, USA
Inflammasome Sensor Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC) Restricts West Nile Virus (WNV) Infection and Spread to the Central Nervous System


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress
This session is from Innate Immunity

Speaker 7 of 8
Petr Broz, University of Lausanne, Switzerland
Canonical and Non-Canonical Inflammasomes Coordinate Host Response to Intracellular Salmonella typhimurium


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 1: Inflammasomes Activation by Pathogens and Stress
This session is from Innate Immunity

Speaker 8 of 8
Sammy Bedoui, University of Melbourne, Australia
NLRC4 Inflammasome Activation in Splenic Dendritic Cells Regulates Anti-Bacterial Effector Function by Memory CD8 T Cells


Tuesday, March 06 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, March 06 | 5:00PM - 7:00PM
Innate Immune Protection against Microbiota (Joint)
Room: Columbine Ballroom

Speaker 1 of 5
* Dan R. Littman, HHMI/New York University School of Medicine, USA

Tuesday, March 06 | 5:00PM - 7:00PM
Innate Immune Protection against Microbiota (Joint)
Room: Columbine Ballroom

Speaker 2 of 5
Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Immune Defense of the Intestinal Epithelial Surface

Tuesday, March 06 | 5:00PM - 7:00PM
Innate Immune Protection against Microbiota (Joint)
Room: Columbine Ballroom

Speaker 3 of 5
Gunnar C. Hansson, University of Gothenburg, Sweden
Good Barriers Encourage Appropriate Microbiota

Tuesday, March 06 | 5:00PM - 7:00PM
Innate Immune Protection against Microbiota (Joint)
Room: Columbine Ballroom

Speaker 4 of 5
Dana Philpott, University of Toronto, Canada
Sensing Bacterial Pathogens by NOD Proteins

Tuesday, March 06 | 5:00PM - 7:00PM
Innate Immune Protection against Microbiota (Joint)
Room: Columbine Ballroom

Speaker 5 of 5
Embriette Alicki, Baylor College of Medicine, USA
Short Talk: The Impact of IgA on the Intestinal Microbiome

Tuesday, March 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak


Tuesday, March 06 | 7:30PM - 10:00PM
Poster Session 2
Room: Torreys Peak


Wednesday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak


Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 1 of 7
* Lora V. Hooper, University of Texas Southwestern Medical Center, USA

Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 2 of 7
Andrew J.S. Macpherson, University of Bern, Switzerland
Immune Compartmentalisation in Mutualism with the Intestinal Microbiota

Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 3 of 7
Maria Rescigno, Humanitas University, Italy
Dendritic Cells in Host-Microbe Interactions in the Intestine

Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 4 of 7
Kiyoshi Takeda, Osaka University, Japan
Regulatory Mechanisms of Immune Responses to Intestinal Bacteria

Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 5 of 7
Sarkis K. Mazmanian, California Institute of Technology, USA
Learning to Tolerate our Microbial Self

Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 6 of 7
Gretchen E. Diehl, Baylor College of Medicine, USA
Short Talk: Commensals Limit Trafficking of Antigens from the Lamina Propria to the Mesenteric Lymph Nodes by CX3CR1+ Cells

Wednesday, March 07 | 8:00AM - 11:15AM
Microbiota Regulation of Innate Immunity (Joint)
Room: Columbine Ballroom

Speaker 7 of 7
Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Short Talk: Lethal Inflammasome Activation by a Multi-Drug Resistant Pathobiont upon Antibiotic Disruption of the Microbiota

Wednesday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, March 07 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak


Wednesday, March 07 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, March 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses
This session is from Innate Immunity

Speaker 1 of 7
* Chris C. Norbury, Pennsylvania State University Medical School, USA


Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses
This session is from Innate Immunity

Speaker 2 of 7
Elina I. Zuniga, University of California, San Diego, USA
Regulation of Type I Interferon Production by Plasmacytoid Dendritic Cell


Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses
This session is from Innate Immunity

Speaker 3 of 7
Dmitry M. Shayakhmetov, Emory University, USA
Virus-Misplaced Host Protein Activates Innate Immunity


Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses
This session is from Innate Immunity

Speaker 4 of 7
Aaron R. Everitt, Wellcome Trust Sanger Institute, UK
IFITM3 Restricts the Morbidity and Mortality Associated with Influenza


Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses
This session is from Innate Immunity

Speaker 5 of 7
Gerard E. Kaiko, University of Newcastle, Australia
Early-Life Viral Infection and TLR7 Susceptibility Gene Interaction Predispose Toward the Development of Asthma in Later-Life


Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses
This session is from Innate Immunity

Speaker 6 of 7
Maulik Patel, Vanderbilt University, USA
Functional Dissection of MAVS Evolution


Wednesday, March 07 | 2:30PM - 4:30PM
Workshop 2: Innate Viral Recognition and IFN Responses
This session is from Innate Immunity

Speaker 7 of 7
Yayoi Izu, Pennsylvania State University, Milton S. Hershey College of Medicine, USA
Non-Classical Endocytosis Bypasses Early Endosomes To Deliver Mousepox Virions Directly to TLR9-Containing Lysosomes in Dendritic Cells, a Requisite Step in Protection from Lethal Infection


Wednesday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, March 07 | 5:00PM - 7:00PM
Lymphocyte-Microbiota Interactions (Joint)
Room: Columbine Ballroom

Speaker 1 of 5
* Ifor Williams, Science Immunology, USA

Wednesday, March 07 | 5:00PM - 7:00PM
Lymphocyte-Microbiota Interactions (Joint)
Room: Columbine Ballroom

Speaker 2 of 5
David Artis, Weill Cornell Medical College, USA
Microbial Regulation of Immune Cell Homeostasis

Wednesday, March 07 | 5:00PM - 7:00PM
Lymphocyte-Microbiota Interactions (Joint)
Room: Columbine Ballroom

Speaker 3 of 5
Dan R. Littman, HHMI/New York University School of Medicine, USA
Microbiota Regulation of Intestinal Lymphocytes

Wednesday, March 07 | 5:00PM - 7:00PM
Lymphocyte-Microbiota Interactions (Joint)
Room: Columbine Ballroom

Speaker 4 of 5
Kenya Honda, Keio University School of Medicine, Japan
Intestinal Commensal Bacteria-Mediated Treg Induction

Wednesday, March 07 | 5:00PM - 7:00PM
Lymphocyte-Microbiota Interactions (Joint)
Room: Columbine Ballroom

Speaker 5 of 5
Timothy W. Hand, NIAID, National Institutes of Health, USA
Short Talk: Gastrointestinal Infection Induces Microbiota-Specific B and T Cell Responses

Wednesday, March 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak


Wednesday, March 07 | 7:30PM - 10:00PM
Poster Session 3
Room: Torreys Peak


Thursday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak


Thursday, March 08 | 8:00AM - 11:00AM
Pattern Recognition Receptors in Health and Disease
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 6 of 6
Felix Yarovinsky, University of Rochester Medical Center, USA
Short Talk: B Cell-Intrinsic TLR Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage


Thursday, March 08 | 8:00AM - 11:00AM
Pattern Recognition Receptors in Health and Disease
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 5 of 6
Vishva M. Dixit, Genentech, Inc., USA
The Inflammasome: What Are the NOD Sensors Sensing?


Thursday, March 08 | 8:00AM - 11:00AM
Pattern Recognition Receptors in Health and Disease
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 4 of 6
Alan Sher, NIAID, National Institutes of Health, USA
Critical Role for Mincle/Card9 Signaling in the IL-1beta Dependent Th17 Polarizing Activity of Mycobacterial Adjuvant


Thursday, March 08 | 8:00AM - 11:00AM
Pattern Recognition Receptors in Health and Disease
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 3 of 6
Herbert (Skip) W. Virgin, Vir Biotechnology, USA
Role of the Virome and Autophagy Proteins in Host Defense and Disease Susceptibility


Thursday, March 08 | 8:00AM - 11:00AM
Pattern Recognition Receptors in Health and Disease
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 2 of 6
Robert L. Coffman, Dynavax Technologies, USA
Translating Innate Signals to Clinical Use


Thursday, March 08 | 8:00AM - 11:00AM
Pattern Recognition Receptors in Health and Disease
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 1 of 6
* Gabriel Nuñez, University of Michigan, USA


Thursday, March 08 | 8:00AM - 11:00AM
Microbiota and Metabolism
Room: Quandary Peak

Speaker 6 of 6
Eran Elinav, Weizmann Institute of Science, Israel
Short Talk: Nod-Like Receptor Proteins Regulate the Steady State and Mucosal Damage Response

Thursday, March 08 | 8:00AM - 11:00AM
Microbiota and Metabolism
Room: Quandary Peak

Speaker 5 of 6
Frederic D. Bushman, University of Pennsylvania, USA
Microbiome Dynamics: Diet and Disease

Thursday, March 08 | 8:00AM - 11:00AM
Microbiota and Metabolism
Room: Quandary Peak

Speaker 4 of 6
Martin J. Blaser, New York University School of Medicine, USA
Animal Models of Microbe-Induced Obesity

Thursday, March 08 | 8:00AM - 11:00AM
Microbiota and Metabolism
Room: Quandary Peak

Speaker 3 of 6
Patrice D. Cani, Université Catholique de Louvain, Belgium
Metabolic Endotoxemia Links Low-Grade Inflammation to Metabolic Diseases

Thursday, March 08 | 8:00AM - 11:00AM
Microbiota and Metabolism
Room: Quandary Peak

Speaker 2 of 6
Fredrik Bäckhed, University of Gothenburg, Sweden
The Gut Microbiota as a Novel Modulator of Host Metabolism and Obesity

Thursday, March 08 | 8:00AM - 11:00AM
Microbiota and Metabolism
Room: Quandary Peak

Speaker 1 of 6
* Jens Walter, APC Microbiome Ireland. University College Cork, Ireland

Thursday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 08 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity
This session is from Innate Immunity

Speaker 6 of 7
Malin E. V. Johansson, University of Gothenburg, Sweden
Mucus Barrier Defects are Associated with Intestinal Inflammation both in Murine Spontaneous Colitis Models and Patients with Ulcerative Colitis


Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity
This session is from Innate Immunity

Speaker 5 of 7
Ty D. Troutman, University of California, San Diego, USA
BCAP is a TIR-Domain Containing Signaling Adaptor Linking TLRs to PI3K/AKT


Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity
This session is from Innate Immunity

Speaker 4 of 7
Adriana R. Mantegazza, Children's Hospital of Philadelphia, USA
AP-3 is Required for Phagosome-Intrinsic TLR Signaling and Subsequent MHC-II Presentation in Dendritic Cells


Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity
This session is from Innate Immunity

Speaker 3 of 7
Alison N. Thorburn, Monash University, Australia
Bacterial Metabolite, Acetate, Suppresses Allergic Airways Disease


Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity
This session is from Innate Immunity

Speaker 2 of 7
Carla V. Rothlin, Yale University, USA
T Cell-Derived Protein S Negatively Regulates the Innate Immune Response


Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity
This session is from Innate Immunity

Speaker 1 of 7
* Ken Shortman, Walter and Eliza Hall Institute of Medical Research, Australia


Thursday, March 08 | 2:30PM - 4:30PM
Workshop 3: Innate Control of Inflammation and Adaptive Immu
nity
This session is from Innate Immunity

Speaker 7 of 7
Iliyan D. Iliev, Weill-Cornell Medical College, USA
Dectin-1 Mediated Mucosal Immunity to Commensal Fungi Influences Colitis


Thursday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 08 | 5:00PM - 7:00PM
Therapeutic Manipulation of Microbiota
Room: Quandary Peak

Speaker 1 of 5
* Alexander Khoruts, University of Minnesota, USA

Thursday, March 08 | 5:00PM - 7:00PM
Therapeutic Manipulation of Microbiota
Room: Quandary Peak

Speaker 2 of 5
Fergus Shanahan, National University of Ireland, Ireland
Making Peace: Altering Host-Microbiota Relationship in Chronic Gut Inflammation

Thursday, March 08 | 5:00PM - 7:00PM
Therapeutic Manipulation of Microbiota
Room: Quandary Peak

Speaker 3 of 5
Philip M. Sherman, Hospital for Sick Children, University of Toronto, Canada
Altering the Pediatric Intestinal Microbiota

Thursday, March 08 | 5:00PM - 7:00PM
Therapeutic Manipulation of Microbiota
Room: Quandary Peak

Speaker 4 of 5
James Versalovic, Texas Children's Hospital, USA
Defining Microbial Disease Signatures in Pediatric Gut Microbiomes – and Microbial Modification Strategies as Therapies

Thursday, March 08 | 5:00PM - 7:00PM
Therapeutic Manipulation of Microbiota
Room: Quandary Peak

Speaker 5 of 5
Marie-Christine Simon, University of Bonn, Germany
Short Talk: Probiotics as a Novel Approach to Modulate Gut Hormone Secretion and Insulin Sensitivity and Secretion

Thursday, March 08 | 5:00PM - 7:00PM
Recognition of Cell Death and Immunity
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 1 of 5
* Gregory M. Barton, University of California, Berkeley, USA


Thursday, March 08 | 5:00PM - 7:00PM
Recognition of Cell Death and Immunity
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 2 of 5
Caetano Reis e Sousa, Francis Crick Institute, UK
Recognition of Cell Death and Adaptive Immunity


Thursday, March 08 | 5:00PM - 7:00PM
Recognition of Cell Death and Immunity
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 3 of 5
Rhea M. Sumpter, Jr., University of Texas Southwestern Medical Center, USA


Thursday, March 08 | 5:00PM - 7:00PM
Recognition of Cell Death and Immunity
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 4 of 5
Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Infection and Apoptosis as a Combined Inflammatory Trigger


Thursday, March 08 | 5:00PM - 7:00PM
Recognition of Cell Death and Immunity
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 5 of 5
Thomas Gajewski, University of Chicago, USA
Short Talk: Innate Immune Sensing of Tumors is Driven by a Cytosolic DNA Sensing/STING Pathway that Induces Host IFN-beta Production and DC Activation


Thursday, March 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak


Thursday, March 08 | 8:00PM - 11:00PM
Entertainment
Room: Torreys Peak


Thursday, March 08 | 8:00PM - 11:00PM
Cash Bar
Room: Torreys Peak


Friday, March 09 | 10:25AM - 10:25AM
Departure


*Session Chair.