Web Desc
Malnutrition, Gut-Microbial Interactions and Mucosal Immunity to Vaccines
Organizer(s): Cecil Czerkinsky, William Petri Jr., Yasmine Belkaid, Gagandeep Kang and Maharaj Kishan Bhan
Date: November 07 - 11, 2011
Location: Le Meridien New Delhi, New Delhi, India
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation.
Summary of Meeting:
Malnutrition is among the most devastating health conditions worldwide, affecting one of three children in developing countries and contributing more than ten million deaths annually. The relationship between nutrition and immunity has been a topic of study for more than five decades. Seminal developments in our understanding of the organization and regulation of the immune system have indicated a close relationship between host nutritional status and systemic immunity. However, surprisingly little is known regarding the impact of nutrition on the mucosal immune system of the digestive tract, a system that functions almost independently from the systemic immune apparatus. Recent research also suggests that the composition and metabolic activity of the gut microbiota modulates intestinal barrier function and immune responsiveness (and vice-versa), and can be affected by specific nutrients or lack of these. This meeting will focus on understanding the role of nutrition in modulating gut immunity to vaccines in order to formulate strategies for improving the performance of enteric vaccines in malnourished children. The objective of this symposium is to formulate innovative hypotheses regarding specific mechanisms by which nutrients and defined microbiota affect gut immunity. A better understanding of the links between nutrients, the gut microbiome and the intestinal immune system is likely to pave the way to the development of innovative approaches that target activation of specific immunological pathways for promoting host’s gut defense. Such knowledge should impact on the development of vaccine formulations and intervention strategies for improved control of enteric infections in developing countries. The Keystone Symposia meeting on Malnutrition, Gut-Microbial Interactions and Mucosal Immunity to Vaccines will benefit from a partnership with the Bill & Melinda Gates Foundation (BMGF), whereby the 2011 business meeting of the BMGF Grand Challenges in Global Health awardees will be held in conjunction with the Keystone Symposia meeting.
Global Health Travel Award Deadline: June 7 2011
Scholarship Deadline: July 11 2011
Discounted Abstract Deadline: July 11 2011
Abstract Deadline: August 10 2011
Discounted Registration Deadline: September 23 2011
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates Foundation
We gratefully acknowledge additional support for this conference from:
Landes Bioscience


Shabirul Haque
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI096802-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, November 07 | 12:00PM - 4:00PM
Registration
Room: Sovereign Foyer


Monday, November 07 | 4:30PM - 4:35PM
Welcoming Remarks (Joint Session with Grand Challenges in Gl
obal Health)
Room: Taj Palace Hotel

Speaker 1 of 1
Chris Wilson, Bill & Melinda Gates Foundation, USA
Innovation and Partnership in India

Monday, November 07 | 4:35PM - 5:20PM
Round Table Discussion on Family Health Research Agenda, Cha
llenges and Funding Opportunities (Joint Session with Grand Challenges in Global Health)

Speaker 1 of 2
Andrew C. Serazin, Bill & Melinda Gates Foundation, USA
GC Healthy Growth

Monday, November 07 | 4:35PM - 5:20PM
Round Table Discussion on Family Health Research Agenda, Cha
llenges and Funding Opportunities (Joint Session with Grand Challenges in Global Health)

Speaker 2 of 2
Yiwu He, Bill & Melinda Gates Foundation, USA
Gut Function and Health Biomarkers

Monday, November 07 | 5:20PM - 6:00PM
Opening Remarks (Joint Session with Grand Challenges in Glob
al Health)

Speaker 1 of 3
Gagandeep Kang, Christian Medical College/Translational Health Science and Technology Institute, India
Introduction to Keystone Meeting Goals

Monday, November 07 | 5:20PM - 6:00PM
Opening Remarks (Joint Session with Grand Challenges in Glob
al Health)

Speaker 2 of 3
Chris Wilson, Bill & Melinda Gates Foundation, USA
Innovation and Partnership in Family Health and Vaccine Science

Monday, November 07 | 5:20PM - 6:00PM
Opening Remarks (Joint Session with Grand Challenges in Glob
al Health)

Speaker 3 of 3
Maharaj Kishan Bhan, Ministry of Science and Technology, Government of India, India
Family Health Innovation and Innovation in India, Sam Pitroda Introduction

Monday, November 07 | 6:00PM - 6:30PM
Keynote Address (Joint Session with Grand Challenges in Glob
al Health)
Room: The Taj Palace Hotel, Shahjehan Hall


Monday, November 07 | 6:30PM - 7:30PM
Joint Reception with GCGH
Room: Raja Bagh Lawn


Monday, November 07 | 7:30PM - 9:00PM
Informal Informational Sessions: Grant Opportunities (Joint
Session with Grand Challenges in Global Health)
Room: B 1-2


Tuesday, November 08 | 7:30AM - 8:30AM
Breakfast
Room: Sovereign


Tuesday, November 08 | 8:30AM - 11:45AM
Epidemiology of Malnutrition
Room: Sovereign

Speaker 1 of 7
Cecil Czerkinsky, International Vaccine Institute, South Korea
Introductory Remarks

Tuesday, November 08 | 8:30AM - 11:45AM
Epidemiology of Malnutrition
Room: Sovereign

Speaker 2 of 7
* Robert E. Black, Johns Hopkins University, Bloomberg School of Public Health, USA
The Global Burden of Malnutrition

Tuesday, November 08 | 8:30AM - 11:45AM
Epidemiology of Malnutrition
Room: Sovereign

Speaker 3 of 7
Andrew M. Prentice, London School of Hygiene and Tropical Medicine, UK
Nutrition-Disease Interactions in the Developing World

Tuesday, November 08 | 8:30AM - 11:45AM
Epidemiology of Malnutrition
Room: Sovereign

Speaker 4 of 7
Mark Manary, Medical College of Malawi, Malawi
The Role of Gut Function and Inflammation in Growth Faltering in Rural Sub-Saharan Africa

Tuesday, November 08 | 8:30AM - 11:45AM
Epidemiology of Malnutrition
Room: Sovereign

Speaker 5 of 7
William A. Petri, Jr., University of Virginia, USA
Genetic Basis of Malnutrition

Tuesday, November 08 | 8:30AM - 11:45AM
Epidemiology of Malnutrition
Room: Sovereign

Speaker 6 of 7
James A. Berkley, KEMRI/Wellcome Trust, Kenya
Short Talk: Severe Acute Malnutrition in Infants Less Than Six Months Old

Tuesday, November 08 | 8:30AM - 11:45AM
Epidemiology of Malnutrition
Room: Sovereign

Speaker 7 of 7
Dilruba Nasrin, University of Maryland, USA
Short Talk: Effect of Moderate to Severe Diarrhea on Linear Growth of Children in Developing Countries

Tuesday, November 08 | 9:40AM - 10:00AM
Coffee Break
Room: Sovereign 1


Tuesday, November 08 | 9:40AM - 10:00AM
Poster Setup
Room: Sovereign 1


Tuesday, November 08 | 11:45AM - 12:30PM
Lunch
Room: Sovereign 1


Tuesday, November 08 | 12:00PM - 3:00PM
Poster Session 1
Room: Sovereign 1


Tuesday, November 08 | 2:30PM - 3:00PM
Coffee Available
Room: Sovereign 1


Tuesday, November 08 | 3:00PM - 5:00PM
Intestinal Barriers
Room: Sovereign

Speaker 1 of 4
* Gail Hecht, University of Illinois at Chicago, USA

Tuesday, November 08 | 3:00PM - 5:00PM
Intestinal Barriers
Room: Sovereign

Speaker 2 of 4
Jerrold R. Turner, University of Chicago, USA
Molecular Basis of Intestinal Barrier Function: Implications for Immune-Mediated Disease

Tuesday, November 08 | 3:00PM - 5:00PM
Intestinal Barriers
Room: Sovereign

Speaker 3 of 4
Gunnar C. Hansson, University of Gothenburg, Sweden
Intestinal Mucus and Host-Microbial Interactions

Tuesday, November 08 | 3:00PM - 5:00PM
Intestinal Barriers
Room: Sovereign

Speaker 4 of 4
Kim E. Barrett, University of California, San Diego, USA
Modulation of Epithelial Barrier and Transport Functions by 'Good' and 'Bad' Bacteria

Tuesday, November 08 | 5:00PM - 5:00PM
On Own for Dinner


Wednesday, November 09 | 7:30AM - 8:30AM
Breakfast
Room: Sovereign


Wednesday, November 09 | 7:30AM - 8:30AM
Poster Setup
Room: Sovereign 1


Wednesday, November 09 | 8:30AM - 11:45AM
Nutrition and the Gut Microbiota
Room: Sovereign

Speaker 1 of 9
* William A. Petri, Jr., University of Virginia, USA

Wednesday, November 09 | 8:30AM - 11:45AM
Nutrition and the Gut Microbiota
Room: Sovereign

Speaker 2 of 9
G. Balakrish Nair, National Institute of Cholera and Enteric Diseases (NICED), India
The Inside Story of the Impoverished Gut

Wednesday, November 09 | 8:30AM - 11:45AM
Nutrition and the Gut Microbiota
Room: Sovereign

Speaker 3 of 9
Elizabeth K. Costello, Stanford University, USA
Assembly of the Human Microbiome during the First Two Years of Life

Wednesday, November 09 | 8:30AM - 11:45AM
Nutrition and the Gut Microbiota
Room: Sovereign

Speaker 4 of 9
Tanya Yatsunenko, Kaleido Biosciences, USA
Short Talk: Human Gut Microbiome in Children with Severe Malnutrition: A Comparative Metagenomic Study of Malawian Twins

Wednesday, November 09 | 8:30AM - 11:45AM
Nutrition and the Gut Microbiota
Room: Sovereign

Speaker 5 of 9
Honorine D. Ward, Tufts Medical Center, USA
Short Talk: The Intestinal Microbiota of Children from Urban and Rural Sites in Pakistan

Wednesday, November 09 | 8:30AM - 11:45AM
Nutrition and the Gut Microbiota
Room: Sovereign

Speaker 6 of 9
Shinji Fukuda, Keio University, Japan
Short Talk: Bifidobacteria can Protect from Enteropathogenic Infection through Production of Acetate

Wednesday, November 09 | 8:30AM - 11:45AM
Nutrition and the Gut Microbiota
Room: Sovereign

Speaker 7 of 9
Ajay Kumar, Colorado State University, USA
Short Talk: Dietary Supplementation with Rice Bran Reduces Susceptibility to Salmonella enterica Typhimurium Infection in Mice via Changes in Gut Microbiota

Wednesday, November 09 | 8:30AM - 11:45AM
Nutrition and the Gut Microbiota
Room: Sovereign

Speaker 8 of 9
Michelle I. Smith, Washington University, St. Louis, USA
Short Talk: Metagenomic Studies of Humanized Gnotobiotic Mice Harboring the Gut Microbiomes of Malawian Twins Discordant for Kwashiorkor

Wednesday, November 09 | 8:30AM - 11:45AM
Nutrition and the Gut Microbiota
Room: Sovereign

Speaker 9 of 9
Beth D. Kirkpatrick, University of Vermont College of Medicine, USA
Short Talk: Exploration of the Biologic Basis for Underperformance of Enteric Vaccines

Wednesday, November 09 | 9:40AM - 10:00AM
Coffee Break
Room: Sovereign 1


Wednesday, November 09 | 11:45AM - 12:30PM
Lunch
Room: Sovereign 1


Wednesday, November 09 | 12:00PM - 3:00PM
Poster Session 2
Room: Sovereign 1


Wednesday, November 09 | 2:30PM - 3:00PM
Coffee Available
Room: Sovereign 1


Wednesday, November 09 | 3:00PM - 5:00PM
Host-Microbial Interactions and Gut Immunity
Room: Sovereign

Speaker 1 of 3
* Yasmine Belkaid, NIAID, National Institutes of Health, USA

Wednesday, November 09 | 3:00PM - 5:00PM
Host-Microbial Interactions and Gut Immunity
Room: Sovereign

Speaker 2 of 3
Gail Hecht, University of Illinois at Chicago, USA
Intestinal Epithelial Responses to Pathogens

Wednesday, November 09 | 3:00PM - 5:00PM
Host-Microbial Interactions and Gut Immunity
Room: Sovereign

Speaker 3 of 3
Wendy S. Garrett, Harvard School of Public Health, USA
Interplay between the Immune System and the Gut Microbiota

Wednesday, November 09 | 5:00PM - 5:00PM
On Own for Dinner


Thursday, November 10 | 7:30AM - 8:30AM
Breakfast
Room: Sovereign


Thursday, November 10 | 7:30AM - 8:30AM
Poster Setup
Room: Sovereign 1


Thursday, November 10 | 8:30AM - 11:30AM
Gut Immunobiology
Room: Sovereign

Speaker 1 of 7
* Cecil Czerkinsky, International Vaccine Institute, South Korea

Thursday, November 10 | 8:30AM - 11:30AM
Gut Immunobiology
Room: Sovereign

Speaker 2 of 7
Per Brandtzaeg, University of Oslo, Norway
Structure and Function of the Human Intestinal Immune System

Thursday, November 10 | 8:30AM - 11:30AM
Gut Immunobiology
Room: Sovereign

Speaker 3 of 7
Martine Heyman, INSERM U989, France
Antigen Handling by the Gut Epithelium for Interaction with the Immune System

Thursday, November 10 | 8:30AM - 11:30AM
Gut Immunobiology
Room: Sovereign

Speaker 4 of 7
Odilia Wijburg, University of Melbourne, Australia
Role of Secretory IgA in Protection and Herd Immunity

Thursday, November 10 | 8:30AM - 11:30AM
Gut Immunobiology
Room: Sovereign

Speaker 5 of 7
Swantje Hammerschmidt, Medical School Hannover, Germany
Short Talk: Retinoic Acid as Adjuvant Induces Homing of Protective T and B Cells to the Gut After Subcutaneous Immunization in Mice

Thursday, November 10 | 8:30AM - 11:30AM
Gut Immunobiology
Room: Sovereign

Speaker 6 of 7
David Haym Schwartz, Hackensack University Medical Center, USA
Short Talk: Induction of Gut IgA after Peripheral Immunization by Manipulation of Vitamins A and D at Sites of Injection

Thursday, November 10 | 8:30AM - 11:30AM
Gut Immunobiology
Room: Sovereign

Speaker 7 of 7
Sean Spencer, University of Pennsylvania, USA
Short Talk: Gastrointestinal Eosinophils Regulate Mucosal CD4+ T Cell Responses and are Controlled by the Dietary Metabolite Retinoic Acid

Thursday, November 10 | 9:40AM - 10:00AM
Coffee Break
Room: Sovereign 1


Thursday, November 10 | 11:30AM - 12:30PM
Lunch
Room: Sovereign 1


Thursday, November 10 | 12:00PM - 3:00PM
Poster Session 3
Room: Sovereign 1


Thursday, November 10 | 2:30PM - 3:00PM
Coffee Available
Room: Sovereign 1


Thursday, November 10 | 3:00PM - 5:00PM
Nutrients, Infectious Diseases and Gut Immunity
Room: Sovereign

Speaker 1 of 4
* Pearay L. Ogra, University of Buffalo, USA

Thursday, November 10 | 3:00PM - 5:00PM
Nutrients, Infectious Diseases and Gut Immunity
Room: Sovereign

Speaker 2 of 4
Charles B. Stephensen, US Department of Agriculture, USA
Nutrition, Infection and Immunity

Thursday, November 10 | 3:00PM - 5:00PM
Nutrients, Infectious Diseases and Gut Immunity
Room: Sovereign

Speaker 3 of 4
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Roles of Vitamin A in Mucosal Immune Responses

Thursday, November 10 | 3:00PM - 5:00PM
Nutrients, Infectious Diseases and Gut Immunity
Room: Sovereign

Speaker 4 of 4
Erika Isolauri, University of Turku, Finland
Modulation of Gut Immunity by Probiotics

Thursday, November 10 | 5:00PM - 5:00PM
On Own for Dinner


Friday, November 11 | 7:30AM - 8:30AM
Breakfast
Room: Sovereign


Friday, November 11 | 8:30AM - 11:30AM
Underperformance of Enteric Vaccines in Developing Countries
Room: Sovereign

Speaker 1 of 4
* Maharaj Kishan Bhan, Ministry of Science and Technology, Government of India, India
Improving the Performance of Vaccines in the Developing World

Friday, November 11 | 8:30AM - 11:30AM
Underperformance of Enteric Vaccines in Developing Countries
Room: Sovereign

Speaker 2 of 4
T. Jacob John, Christian Medical College, India
Improving the Performance of Enteric Vaccines in Developing Countries: Oral Polio Vaccine

Friday, November 11 | 8:30AM - 11:30AM
Underperformance of Enteric Vaccines in Developing Countries
Room: Sovereign

Speaker 3 of 4
Gagandeep Kang, Christian Medical College/Translational Health Science and Technology Institute, India
Rotavirus Vaccines

Friday, November 11 | 8:30AM - 11:30AM
Underperformance of Enteric Vaccines in Developing Countries
Room: Sovereign

Speaker 4 of 4
Richard Walker, PATH, USA
Developing ETEC and Shigella Vaccines for Children in Developing Countries

Friday, November 11 | 9:40AM - 10:00AM
Coffee Break
Room: Sovereign 1


Friday, November 11 | 10:25AM - 10:25AM
Departure


*Session Chair.

Friday, November 11 | 11:30AM - 2:30PM
On Own for Lunch and Recreation


Friday, November 11 | 2:30PM - 3:00PM
Coffee Available
Room: Sovereign 1


Friday, November 11 | 3:00PM - 5:00PM
Strategies for Improving the Immunogenicity of Enteric Vacci
nes

Room: Sovereign

Speaker 1 of 4
* Richard Walker, PATH, USA

Friday, November 11 | 3:00PM - 5:00PM
Strategies for Improving the Immunogenicity of Enteric Vacci
nes

Room: Sovereign

Speaker 2 of 4
Gregory M. Glenn, Novavax, USA
Transcutaneous Immunization

Friday, November 11 | 3:00PM - 5:00PM
Strategies for Improving the Immunogenicity of Enteric Vacci
nes

Room: Sovereign

Speaker 3 of 4
Firdausi Qadri, International Centre for Diarrhoeal Disease Research, Bangladesh
Supplementation with Micronutrients and Withdrawal from Breast Feeding: Effects on the Immunogenicity of Enteric Vaccines

Friday, November 11 | 3:00PM - 5:00PM
Strategies for Improving the Immunogenicity of Enteric Vacci
nes

Room: Sovereign

Speaker 4 of 4
Cecil Czerkinsky, International Vaccine Institute, South Korea
Alternative Routes of Vaccine Delivery

Friday, November 11 | 5:00PM - 6:30PM
Social Hour with Lite Bites
Room: Allure/Pre Function