Web Desc
Ubiquitin Signaling
joint with NF-kappaB Signaling and Biology: From Bench to Bedside
Organizer(s): Ivan Dikic and Raymond J. Deshaies
Date: March 18 - 23, 2012
Location: Whistler Conference Centre, Whistler, BC, Canada
Supported by the Directors' Fund
Summary of Meeting:
Post-translational modifications of cellular proteins by ubiquitin and ubiquitin-like modifiers regulate a variety of functions in the cell. A crucial aspect of signaling through ubiquitin and Ubls is the presence of modular binding domains that recognize particular types of ubiquitin signals. Such molecular coupling creates an attractive “decoding” mechanism for responding to alterations in the cellular microenvironment and regulating physiological and pathophysiological conditions. In this meeting, we will discuss the major challenges in the field including detection of endogenous ubiquitination events, functional aspects of novel types of ubiquitin chains and their recognition by selective binding domains, and high-throughput technologies for comprehensive analysis of Ub modifications. The intersection between the deregulated ubiquitin signaling, pathogenesis of human diseases and therapies targeting the Ub system will be explored. The program offers a possibility for young scientists to present their own work and engage in discussions on the emerging topics in the field. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on NF-kB Signaling and Biology: From Bench to Bedside, which will share a keynote address and three plenary sessions with this meeting.
Scholarship Deadline: November 16 2011
Discounted Abstract Deadline: November 16 2011
Abstract Deadline: December 20 2011
Discounted Registration Deadline: January 18 2012
We gratefully acknowledge additional support for this conference from:
Boston Biochem, an R&D Systems CompanyCell Signaling Technology, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

Millennium Pharmaceuticals, Inc., The Takeda Oncology Company
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 18 | 3:00PM - 7:30PM
Registration
Room: Grand Foyer


Sunday, March 18 | 6:15PM - 7:15PM
Refreshments
Room: Grand Foyer


Sunday, March 18 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 1 of 4
* Michael Karin, University of California, San Diego, USA

Sunday, March 18 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 2 of 4
David Baltimore, California Institute of Technology, USA
25 Years of the NF-kappaB Pathway

Sunday, March 18 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 3 of 4
* Ivan Dikic, Goethe University Medical School, Germany

Sunday, March 18 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 4 of 4
Aaron J. Ciechanover, Technion-Israel Institute of Technology, Israel
The Ubiquitin Proteolytic System: From Basic Mechanisms through Human Diseases and on to Drug Targeting

Monday, March 19 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Monday, March 19 | 8:00AM - 11:15AM
Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint
)

Room: Sea to Sky B/C

Speaker 1 of 8
* Claudio A. P. Joazeiro, University of Heidelberg, Germany

Monday, March 19 | 8:00AM - 11:15AM
Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint
)

Room: Sea to Sky B/C

Speaker 2 of 8
* Henning Walczak, University College London, Cancer Institute, UK

Monday, March 19 | 8:00AM - 11:15AM
Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint
)

Room: Sea to Sky B/C

Speaker 3 of 8
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Ubiquitin Signaling in the RIG-I Antiviral Pathway

Monday, March 19 | 8:00AM - 11:15AM
Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint
)

Room: Sea to Sky B/C

Speaker 4 of 8
Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Structural and Functional Analyses of NF-kappaB and Cell Death Signaling

Monday, March 19 | 8:00AM - 11:15AM
Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint
)

Room: Sea to Sky B/C

Speaker 5 of 8
Domagoj Vucic, Genentech, Inc., USA
Short Talk: IAP Antagonists and TNF Receptors Differentially Regulate C-IAP Ubiquitin Ligase Activity

Monday, March 19 | 8:00AM - 11:15AM
Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint
)

Room: Sea to Sky B/C

Speaker 6 of 8
Ivan Dikic, Goethe University Medical School, Germany
Ubiquitin Networks in Regulation of NF-kappB Activation

Monday, March 19 | 8:00AM - 11:15AM
Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint
)

Room: Sea to Sky B/C

Speaker 7 of 8
Kazuhiro Iwai, Osaka University, Japan
Linear Polyubiquitination: A Crucial Regulator of NF-kappaB Signaling

Monday, March 19 | 8:00AM - 11:15AM
Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint
)

Room: Sea to Sky B/C

Speaker 8 of 8
Katrin E. Rittinger, Francis Crick Institute, UK
Short Talk: Mechanism of Linear Ubiquitin Chain Formation by the E3 Ligase Ccomplex LUBAC

Monday, March 19 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Monday, March 19 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Monday, March 19 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, March 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Monday, March 19 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Monday, March 19 | 5:00PM - 7:00PM
Ubiquitin Conjugation/Deconjugation Machineries
Room: Sea to Sky B

Speaker 1 of 6
* Scott D. Emr, Cornell University, USA

Monday, March 19 | 5:00PM - 7:00PM
Ubiquitin Conjugation/Deconjugation Machineries
Room: Sea to Sky B

Speaker 2 of 6
* Jon Huibregtse, University of Texas at Austin, USA

Monday, March 19 | 5:00PM - 7:00PM
Ubiquitin Conjugation/Deconjugation Machineries
Room: Sea to Sky B

Speaker 3 of 6
Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Structural Biology of E3 Ubiquitin Ligase Enzymes

Monday, March 19 | 5:00PM - 7:00PM
Ubiquitin Conjugation/Deconjugation Machineries
Room: Sea to Sky B

Speaker 4 of 6
Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: CRL4CSA/DDB2 Ubiquitin Ligase Architecture, Targeting to Chromatin and Cop9 Signalosome Mediated Regulation

Monday, March 19 | 5:00PM - 7:00PM
Ubiquitin Conjugation/Deconjugation Machineries
Room: Sea to Sky B

Speaker 5 of 6
Claudio A. P. Joazeiro, University of Heidelberg, Germany
Listerin/Ltn1, an E3 Ligase Implicated in Neurodegeneration, Mediates a Novel Pathway of Cytoplasmic Protein Quality Control

Monday, March 19 | 5:00PM - 7:00PM
Ubiquitin Conjugation/Deconjugation Machineries
Room: Sea to Sky B

Speaker 6 of 6
Keith D. Wilkinson, Emory University, USA
Roles of the BAP1 Deubiquitinating Enzyme in Tumor Suppression

Monday, March 19 | 5:00PM - 7:00PM
NF-kappaB and Transcription
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 1 of 6
* Thomas D. Gilmore, Boston University, USA


Monday, March 19 | 5:00PM - 7:00PM
NF-kappaB and Transcription
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 2 of 6
Alexander Hoffmann, University of California, Los Angeles, USA
NF-kappaB Functions within the Pathogen-Responsive Gene Regulatory Network


Monday, March 19 | 5:00PM - 7:00PM
NF-kappaB and Transcription
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 3 of 6
Stephen T. Smale, University of California, Los Angeles, USA
Transcriptional Specificity of an NF-kappaB Response


Monday, March 19 | 5:00PM - 7:00PM
NF-kappaB and Transcription
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 4 of 6
Ruaidhrí John Carmody, University College Cork, Ireland
Short Talk: De-Ubiquitination of NF-kappaB by Ubiquitin-Specific Protease-7 Promotes Transcription


Monday, March 19 | 5:00PM - 7:00PM
NF-kappaB and Transcription
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 5 of 6
Sulakshana P. Mukherjee, University of California, San Diego, USA
Short Talk: Insights into the RelA:CBP Interaction in Transcription Regulation


Monday, March 19 | 5:00PM - 7:00PM
NF-kappaB and Transcription
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 6 of 6
Matthew E. Pipkin, The Scripps Research Institute, USA
Short Talk: NFAT Transcription Factors Control Transcriptional Elongation in Memory CD8 T Cells


Monday, March 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Monday, March 19 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Tuesday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Tuesday, March 20 | 8:00AM - 11:15AM
Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi
nt)

Room: Sea to Sky B/C

Speaker 1 of 8
* J. Wade Harper, Harvard Medical School, USA

Tuesday, March 20 | 8:00AM - 11:15AM
Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi
nt)

Room: Sea to Sky B/C

Speaker 2 of 8
* Hao Wu, Harvard Medical School, Boston Children's Hospital, USA

Tuesday, March 20 | 8:00AM - 11:15AM
Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi
nt)

Room: Sea to Sky B/C

Speaker 3 of 8
Margot Thome, University of Lausanne, Switzerland
Role of the MALT1 Protease Activity in Adaptive Immunity and Lymphoma

Tuesday, March 20 | 8:00AM - 11:15AM
Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi
nt)

Room: Sea to Sky B/C

Speaker 4 of 8
Sarah Spiegel, Virginia Commonwealth University, USA
Regulation of RING E3 Ubiquitin Ligases by Sphingosine-1-Phosphate

Tuesday, March 20 | 8:00AM - 11:15AM
Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi
nt)

Room: Sea to Sky B/C

Speaker 5 of 8
Kristopher Clark, University of Dundee, UK
Short Talk: Cross-Talk within the IkappaB Kinase Family is Required to Limit NF-kappaB Signaling and Prevent Autoimmunity

Tuesday, March 20 | 8:00AM - 11:15AM
Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi
nt)

Room: Sea to Sky B/C

Speaker 6 of 8
Michael Karin, University of California, San Diego, USA
Ub Cascades in Innate Immunity

Tuesday, March 20 | 8:00AM - 11:15AM
Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi
nt)

Room: Sea to Sky B/C

Speaker 7 of 8
Vishva M. Dixit, Genentech, Inc., USA
Regulation of Pro-Inflammatory Receptor Signaling by Ubiquitin Hydrolases

Tuesday, March 20 | 8:00AM - 11:15AM
Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi
nt)

Room: Sea to Sky B/C

Speaker 8 of 8
Henning Walczak, University College London, Cancer Institute, UK
Short Talk: Linear Ubiquitination in Cell Death, Inflammation and Immunity

Tuesday, March 20 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Tuesday, March 20 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Tuesday, March 20 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 1 of 9
* Manolis Pasparakis, University of Cologne, Germany


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 2 of 9
Dirk Brenner, Luxembourg Institute of Health, Luxembourg
MALT1 is Indispensable for an Inflammatory Th17 Cell Response


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 3 of 9
Thomas D. Gilmore, Boston University, USA
Evolutionary Origins of NF-kappaB Signaling


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 4 of 9
Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
CARD11 Lymphoma Mutations Switch Self-Antigen Induced B Cell Death into Growth


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 5 of 9
Marie Anne O'Donnell, Rockefeller, USA
CASPASE 8 is a Dexterous Killer with a Heart


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 6 of 9
Michael J. May, University of Pennsylvania, USA
A Novel Role for cIAPs in IkappaBepsilon Degradation


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 7 of 9
Fabrice Agou, Institut Pasteur, France
Two-Sided Ubiquitin Binding Explains the EDA-ID-Related Mutations of NEMO ZF


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 8 of 9
Steven C. Ley, Francis Crick Institute, UK
Regulation of Immune Responses by IKK-Induced NF-kappaB1 p105 Proteolysis


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 9 of 9
Carolyn Gray, University of Pennsylvania, USA
A Role for NEMO in the Non-Canonical NF-kappaB Signaling Pathway


Tuesday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Tuesday, March 20 | 5:00PM - 7:00PM
Ubiquitin Chains and Ubiquitin-Binding Domains (UBDs)
Room: Sea to Sky B

Speaker 1 of 6
* Keith D. Wilkinson, Emory University, USA

Tuesday, March 20 | 5:00PM - 7:00PM
Ubiquitin Chains and Ubiquitin-Binding Domains (UBDs)
Room: Sea to Sky B

Speaker 2 of 6
* Eilika Weber-Ban, ETH Zürich, Switzerland

Tuesday, March 20 | 5:00PM - 7:00PM
Ubiquitin Chains and Ubiquitin-Binding Domains (UBDs)
Room: Sea to Sky B

Speaker 3 of 6
Kay Hofmann, University of Cologne, Germany
Bioinformatical Discovery and Characterization of Ubiquitin-Binding Domains

Tuesday, March 20 | 5:00PM - 7:00PM
Ubiquitin Chains and Ubiquitin-Binding Domains (UBDs)
Room: Sea to Sky B

Speaker 4 of 6
Michael Rape, University of California, Berkeley, USA
Function and Assembly of Lysine 11-Linked Ubiquitin Chains

Tuesday, March 20 | 5:00PM - 7:00PM
Ubiquitin Chains and Ubiquitin-Binding Domains (UBDs)
Room: Sea to Sky B

Speaker 5 of 6
Scott D. Emr, Cornell University, USA
Ubiquitin-Mediated Endocytosis and Down-Regulation of PM Proteins

Tuesday, March 20 | 5:00PM - 7:00PM
Ubiquitin Chains and Ubiquitin-Binding Domains (UBDs)
Room: Sea to Sky B

Speaker 6 of 6
Andreas Ernst, University of Toronto, Canada
Short Talk: A General Strategy to Generate Inhibitors of the Ubiquitin System

Tuesday, March 20 | 5:00PM - 7:00PM
NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 1 of 4
* Alexander Hoffmann, University of California, Los Angeles, USA


Tuesday, March 20 | 5:00PM - 7:00PM
NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 2 of 4
Takashi Fujita, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan
Antiviral Innate Immunity: Control of Interferon Production


Tuesday, March 20 | 5:00PM - 7:00PM
NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 3 of 4
Paulina A. Bartuzi, University Medical Center Groningen, Netherlands
Short Talk: Hepatic Depletion of Commd1 Ameliorates Liver Inflammation in a Mouse Model of Non-Alcoholic Steatohepatitis


Tuesday, March 20 | 5:00PM - 7:00PM
NF-kappaB in Inflammation and Immunity
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 4 of 4
Steve D. Gerondakis, Monash University, Australia
Short Talk: c-Rel Controls Multiple Steps in the Development of Thymic CD4 Regulatory T Cells


Tuesday, March 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Tuesday, March 20 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Wednesday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Wednesday, March 21 | 8:00AM - 11:15AM
Ubiquitin Signaling and Diseases
Room: Sea to Sky B

Speaker 1 of 8
* Raymond J. Deshaies, Amgen, Inc., USA

Wednesday, March 21 | 8:00AM - 11:15AM
Ubiquitin Signaling and Diseases
Room: Sea to Sky B

Speaker 2 of 8
* Mary C. Dasso, National Institutes of Health, NICHD, USA

Wednesday, March 21 | 8:00AM - 11:15AM
Ubiquitin Signaling and Diseases
Room: Sea to Sky B

Speaker 3 of 8
Karen H. Vousden, Francis Crick Institute, UK
Ubiquitin Signaling in the Regulation of p53

Wednesday, March 21 | 8:00AM - 11:15AM
Ubiquitin Signaling and Diseases
Room: Sea to Sky B

Speaker 4 of 8
Agata Smogorzewska, Rockefeller University, USA
Ubiquitin Signaling in DNA Damage and Repair

Wednesday, March 21 | 8:00AM - 11:15AM
Ubiquitin Signaling and Diseases
Room: Sea to Sky B

Speaker 5 of 8
Mads Daugaard, University of British Columbia, Canada
Short Talk: The Hace1 E3 Ligase Blocks NADPH Oxidase Generation of Superoxide by Targeting Rac1 for Proteasomal Degradation

Wednesday, March 21 | 8:00AM - 11:15AM
Ubiquitin Signaling and Diseases
Room: Sea to Sky B

Speaker 6 of 8
Pier Paolo Di Fiore, FIRC Institute of Molecular Oncology, Italy
Ubiquitin Pathways in Stem Cells

Wednesday, March 21 | 8:00AM - 11:15AM
Ubiquitin Signaling and Diseases
Room: Sea to Sky B

Speaker 7 of 8
Judith Frydman, Stanford University, USA
Protein Aggregation and Neurodegeneration

Wednesday, March 21 | 8:00AM - 11:15AM
Ubiquitin Signaling and Diseases
Room: Sea to Sky B

Speaker 8 of 8
Andreas Martin, University of California, Berkeley, USA
Short Talk: Complete Subunit Architecture of the 26S Proteasome Reveals Mechanisms of Ubiquitin-Dependent Substrate Degradation

Wednesday, March 21 | 8:00AM - 11:30AM
Cell Death Signaling and Its Regulation by Ubiquitin and NF-
kappaB
This session is from NF-kappaB

Room: Sea to Sky C

Speaker 1 of 8
* Domagoj Vucic, Genentech, Inc., USA


Wednesday, March 21 | 8:00AM - 11:30AM
Cell Death Signaling and Its Regulation by Ubiquitin and NF-
kappaB
This session is from NF-kappaB

Room: Sea to Sky C

Speaker 2 of 8
Francis Ka-Ming Chan, Duke University, USA
Regulation of Cell Death and Cell Survival by the RIP Kinases


Wednesday, March 21 | 8:00AM - 11:30AM
Cell Death Signaling and Its Regulation by Ubiquitin and NF-
kappaB
This session is from NF-kappaB

Room: Sea to Sky C

Speaker 3 of 8
Ingrid E. Wertz, Genentech, Inc., USA
Molecular Mechanisms of NF-kappaB Regulation by the Ubiquitin Editing Enzyme A20


Wednesday, March 21 | 8:00AM - 11:30AM
Cell Death Signaling and Its Regulation by Ubiquitin and NF-
kappaB
This session is from NF-kappaB

Room: Sea to Sky C

Speaker 4 of 8
Genhong Cheng, University of California, Los Angeles, USA
TRAF3 at the Crossroads of Antiviral and Inflammatory Responses


Wednesday, March 21 | 8:00AM - 11:30AM
Cell Death Signaling and Its Regulation by Ubiquitin and NF-
kappaB
This session is from NF-kappaB

Room: Sea to Sky C

Speaker 5 of 8
Zheng gang Liu, NCI, National Institutes of Health, USA
Understanding the Regulation of TNF-Induced Cell Death


Wednesday, March 21 | 8:00AM - 11:30AM
Cell Death Signaling and Its Regulation by Ubiquitin and NF-
kappaB
This session is from NF-kappaB

Room: Sea to Sky C

Speaker 6 of 8
Andrew Oberst, University of Washington, USA
Short Talk: Cooperation of FADD, Caspase-8, and FLIP is Required to Prevent RIPK3-Dependent Programmed Necrosis during Embryonic Development


Wednesday, March 21 | 8:00AM - 11:30AM
Cell Death Signaling and Its Regulation by Ubiquitin and NF-
kappaB
This session is from NF-kappaB

Room: Sea to Sky C

Speaker 7 of 8
Anning Lin, Shanghai Institute of Biochemistry and Cell Biology, China
Short Talk: Novel Signaling by the IKK Complex


Wednesday, March 21 | 8:00AM - 11:30AM
Cell Death Signaling and Its Regulation by Ubiquitin and NF-
kappaB
This session is from NF-kappaB

Room: Sea to Sky C

Speaker 8 of 8
Seda Çöl Arslan, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: TAK1-RIP1 Interplay Determines the Prevalence of TNFalpha-Induced Programmed Necrosis over Apoptosis


Wednesday, March 21 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Wednesday, March 21 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Wednesday, March 21 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Wednesday, March 21 | 1:30PM - 3:00PM
Workshop 1: Novel Techniques to Track Ub Signals
Room: Sea to Sky B

Speaker 1 of 7
* Steven P. Gygi, Harvard Medical School, USA

Wednesday, March 21 | 1:30PM - 3:00PM
Workshop 1: Novel Techniques to Track Ub Signals
Room: Sea to Sky B

Speaker 2 of 7
* Ingrid E. Wertz, Genentech, Inc., USA

Wednesday, March 21 | 1:30PM - 3:00PM
Workshop 1: Novel Techniques to Track Ub Signals
Room: Sea to Sky B

Speaker 3 of 7
Eric J. Bennett, University of California, San Diego, USA
Monitoring Proteome Fidelity through Quantitative Analysis of Endogenous Ubiquitin Targets

Wednesday, March 21 | 1:30PM - 3:00PM
Workshop 1: Novel Techniques to Track Ub Signals
Room: Sea to Sky B

Speaker 4 of 7
Bradley B. Brasher, Boston Biochem, Inc., USA
Non-Hydrolyzable Polyubiquitin Chains: Development and Characterization of New Reagents for Signal Transduction Studies

Wednesday, March 21 | 1:30PM - 3:00PM
Workshop 1: Novel Techniques to Track Ub Signals
Room: Sea to Sky B

Speaker 5 of 7
Arno F. Alpi, University of Dundee, UK
Regulation of Cullin Neddylation by the Ariadne Subfamily of RING-in-between-RING E3 Ubiquitin Ligases

Wednesday, March 21 | 1:30PM - 3:00PM
Workshop 1: Novel Techniques to Track Ub Signals
Room: Sea to Sky B

Speaker 6 of 7
Simon Bekker-Jensen, University of Copenhagen, Denmark
Ubiquitin-Dependent Regulation of PAF15 Promotes Cellular Responses to Replication Blocks

Wednesday, March 21 | 1:30PM - 3:00PM
Workshop 1: Novel Techniques to Track Ub Signals
Room: Sea to Sky B

Speaker 7 of 7
Fumiyo Ikeda, IMBA – Institute of Molecular Biotechnology, Austria
Sharpin-Dependent Linear-Ubiquitination is Required for Cell Survival Pathway

Wednesday, March 21 | 3:00PM - 4:30PM
Workshop 2: Disease Models and Novel Therapies
Room: Sea to Sky B

Speaker 1 of 7
* Karen H. Vousden, Francis Crick Institute, UK

Wednesday, March 21 | 3:00PM - 4:30PM
Workshop 2: Disease Models and Novel Therapies
Room: Sea to Sky B

Speaker 2 of 7
* Teresa Soucy, Millennium Pharmaceuticals, Inc., USA

Wednesday, March 21 | 3:00PM - 4:30PM
Workshop 2: Disease Models and Novel Therapies
Room: Sea to Sky B

Speaker 3 of 7
Valentina Perissi, Boston University School of Medicine, USA
A Protective Strategy against Hyper-Inflammatory Responses Requiring GPS2 Inhibition of TRAF2 Enzymatic Activity

Wednesday, March 21 | 3:00PM - 4:30PM
Workshop 2: Disease Models and Novel Therapies
Room: Sea to Sky B

Speaker 4 of 7
Koraljka Husnjak, Institute of Biochemistry II, Germany
Elucidating the Role of Proteasomal Ubiquitin Receptor Rpn13 in Growth and Development

Wednesday, March 21 | 3:00PM - 4:30PM
Workshop 2: Disease Models and Novel Therapies
Room: Sea to Sky B

Speaker 5 of 7
Lynn Boyden, Yale University School of Medicine, USA
Mutations in Kelch-Like 3 and Cullin 3 Implicate Ubiquitination in Regulation of Electrolyte Homeostasis and Blood Pressure

Wednesday, March 21 | 3:00PM - 4:30PM
Workshop 2: Disease Models and Novel Therapies
Room: Sea to Sky B

Speaker 6 of 7
Mads Gyrd-Hansen, University of Oxford, UK
XIAP Ubiquitylates RIPK2 and Recruits LUBAC to Regulate Innate Immune Signaling

Wednesday, March 21 | 3:00PM - 4:30PM
Workshop 2: Disease Models and Novel Therapies
Room: Sea to Sky B

Speaker 7 of 7
Marene Landstrom, Umeå University, Sweden
The Molecular Mechanisms which Determines how TGF-beta Can Act as a Tumor Promoter

Wednesday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Wednesday, March 21 | 5:00PM - 7:00PM
Proteome Analysis of Ub System
Room: Sea to Sky B

Speaker 1 of 6
* Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany

Wednesday, March 21 | 5:00PM - 7:00PM
Proteome Analysis of Ub System
Room: Sea to Sky B

Speaker 2 of 6
* Pier Paolo Di Fiore, FIRC Institute of Molecular Oncology, Italy

Wednesday, March 21 | 5:00PM - 7:00PM
Proteome Analysis of Ub System
Room: Sea to Sky B

Speaker 3 of 6
Lan Huang, University of California, Irvine, USA
Understanding the Ubiquitin-Proteasome System by Probing Protein-Protein Interactions

Wednesday, March 21 | 5:00PM - 7:00PM
Proteome Analysis of Ub System
Room: Sea to Sky B

Speaker 4 of 6
J. Wade Harper, Harvard Medical School, USA
Proteomic Exploration of the Ubiquitin System

Wednesday, March 21 | 5:00PM - 7:00PM
Proteome Analysis of Ub System
Room: Sea to Sky B

Speaker 5 of 6
Steven P. Gygi, Harvard Medical School, USA
Analyzing the Ubiquitin-Modified Proteome

Wednesday, March 21 | 5:00PM - 7:00PM
Proteome Analysis of Ub System
Room: Sea to Sky B

Speaker 6 of 6
Thibault Mayor, University of British Columbia, Canada
Short Talk: Systems-Wide Analysis Reveals that Low Abundant Disordered Proteins are Prone to Ubiquitylation after Misfolding Stress

Wednesday, March 21 | 5:00PM - 7:15PM
NF-kappaB and Disease
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 1 of 6
* Alain Israël, Institut Pasteur, France


Wednesday, March 21 | 5:00PM - 7:15PM
NF-kappaB and Disease
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 2 of 6
Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
NF-kappaB in Cancer


Wednesday, March 21 | 5:00PM - 7:15PM
NF-kappaB and Disease
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 3 of 6
Manolis Pasparakis, University of Cologne, Germany
IKK/NF-kappaB Signaling in Epithelial Homeostasis and Inflammation


Wednesday, March 21 | 5:00PM - 7:15PM
NF-kappaB and Disease
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 4 of 6
Jean-Laurent Casanova, Rockefeller University, USA
Life-Threatening Infectious Diseases of Childhood: Single-Gene Inborn Errors of Immunity?


Wednesday, March 21 | 5:00PM - 7:15PM
NF-kappaB and Disease
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 5 of 6
Ethel Cesarman, Weill Cornell Medical College, USA
Short Talk: Central Role of vFLIP-Induced NF-kappaB in the Pathobiology of KSHV-Associated Malignancies


Wednesday, March 21 | 5:00PM - 7:15PM
NF-kappaB and Disease
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 6 of 6
Vasant Chellappa, Massachusetts General Hospital, USA
Short Talk: Somatic Mutations of RIPK4/PKK Drive NF-kappaB Dependent Cancers while Germline Variants Compromise NF-kappaB Signaling in an Inherited Syndrome Involving Defective Epidermal Differentiation


Wednesday, March 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Wednesday, March 21 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky A


Thursday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Thursday, March 22 | 8:00AM - 11:15AM
Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th
erapy (Joint)

Room: Sea to Sky B/C

Speaker 1 of 7
* Michael Rape, University of California, Berkeley, USA

Thursday, March 22 | 8:00AM - 11:15AM
Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th
erapy (Joint)

Room: Sea to Sky B/C

Speaker 2 of 7
Raymond J. Deshaies, Amgen, Inc., USA
Prospecting for Drug Targets in the Ubiquitin-Proteasome System

Thursday, March 22 | 8:00AM - 11:15AM
Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th
erapy (Joint)

Room: Sea to Sky B/C

Speaker 3 of 7
Teresa Soucy, Millennium Pharmaceuticals, Inc., USA
Mechanism-Based E1 Inhibitors Offer New Insights into Ubiquitin-Like Protein Conjugation

Thursday, March 22 | 8:00AM - 11:15AM
Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th
erapy (Joint)

Room: Sea to Sky B/C

Speaker 4 of 7
Daniel Krappmann, Helmholtz Zentrum München, Germany
Short Talk: Targeting the NEMO-Ubiquitin Interface with Small Molecules - New Strategy for the Design of Pharmacological NF-kappaB Inhibitors

Thursday, March 22 | 8:00AM - 11:15AM
Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th
erapy (Joint)

Room: Sea to Sky B/C

Speaker 5 of 7
Alain Israël, Institut Pasteur, France
Human Pathology Associated with Deficiency in HOIL-1, One of the Components of the LUBAC Ubiquitin Ligase Complex

Thursday, March 22 | 8:00AM - 11:15AM
Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th
erapy (Joint)

Room: Sea to Sky B/C

Speaker 6 of 7
Philip Cohen, University of Dundee, UK
Novel Cross-Talk within the IKK Family Controls Signaling to NF-kappaB

Thursday, March 22 | 8:00AM - 11:15AM
Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th
erapy (Joint)

Room: Sea to Sky B/C

Speaker 7 of 7
Neal Silverman, University of Massachusetts Medical School, USA
Short Talk: Caspase Mediated Cleavage, IAP Binding and Ubiquitination Drive Drosophila NF-kappaB Signaling

Thursday, March 22 | 9:00AM - 9:20AM
Coffee Break
Room: Grand Foyer


Thursday, March 22 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB in Cancer and Other Diseases
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 1 of 9
* Francis Ka-Ming Chan, Duke University, USA


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB in Cancer and Other Diseases
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 2 of 9
Bernd Baumann, University of Ulm, Germany
beta-Cell Specific Changes in IKK/NF-kappaB Signaling Interfere with beta-Cell Homeostasis and Result in Diabetes-Like Phenotypes


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB in Cancer and Other Diseases
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 3 of 9
Katy Billot, INSERM U1016 Institut Cochin, France
RelB Inhibits Cell Proliferation and Tumor Growth through p53 Transcriptional Activation


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB in Cancer and Other Diseases
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 4 of 9
Brent Cameron, Case Western Reserve University, USA
Loss of IRAK4 Function Alters Microglial Response and Enhances Clearance of Abeta from the Brain in an Alzheimer’s Disease Mouse Model


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB in Cancer and Other Diseases
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 5 of 9
Carter Van Waes, NIDCD, National Institutes of Health, USA
Novel c-REL/RELA Interactions with deltaNp63alpha Dysregulate NF-kappaB and p73 Target Genes in Head and Neck Cancer


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB in Cancer and Other Diseases
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 6 of 9
Bryant G. Darnay, University of Texas MD Anderson Cancer Center, USA
New Genetic Lesion Identified in AML Revealed by a Mouse Model for Myeloid-Specific Deletion of TAK1


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB in Cancer and Other Diseases
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 7 of 9
Jean-Pierre Julien, Université Laval, Canada
TDP-43 Drives NF-kappaB-Mediated Pathogenic Pathways in Amyotrophic Lateral Sclerosis


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB in Cancer and Other Diseases
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 8 of 9
Alessandra Agresti, San Raffaele Scientific Institute, Italy
Smart Drugs to Counteract NF-kappaB Driven Proliferation in Multiple Myeloma


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB in Cancer and Other Diseases
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 9 of 9
Brian C. Schaefer, Uniformed Services University, USA
Selective Autophagy of Bcl10 Modulates T Cell Receptor Activation of NF-kappaB – New Targets for Intervention in Lymphocyte Cancers and Lymphocyte Functional Responses


Thursday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Thursday, March 22 | 5:00PM - 7:00PM
Ubiquitin-Like Modifiers in Signaling
Room: Sea to Sky B

Speaker 1 of 6
* Agata Smogorzewska, Rockefeller University, USA

Thursday, March 22 | 5:00PM - 7:00PM
Ubiquitin-Like Modifiers in Signaling
Room: Sea to Sky B

Speaker 2 of 6
* Kay Hofmann, University of Cologne, Germany

Thursday, March 22 | 5:00PM - 7:00PM
Ubiquitin-Like Modifiers in Signaling
Room: Sea to Sky B

Speaker 3 of 6
Mary C. Dasso, National Institutes of Health, NICHD, USA
Regulation of Ribosome Biogenesis through the deSUMOylating Enzyme SENP3

Thursday, March 22 | 5:00PM - 7:00PM
Ubiquitin-Like Modifiers in Signaling
Room: Sea to Sky B

Speaker 4 of 6
Eilika Weber-Ban, ETH Zürich, Switzerland
Pupylation – Ubiquitin-Like Pathway in Bacteria

Thursday, March 22 | 5:00PM - 7:00PM
Ubiquitin-Like Modifiers in Signaling
Room: Sea to Sky B

Speaker 5 of 6
Jon Huibregtse, University of Texas at Austin, USA
Mechanism and Function of ISG15 Conjugation

Thursday, March 22 | 5:00PM - 7:00PM
Ubiquitin-Like Modifiers in Signaling
Room: Sea to Sky B

Speaker 6 of 6
Minghua Nie, The Scripps Research Institute, USA
Short Talk: A Role for the Cdc48Ufd1-Npl4 Complex in the Function of STUbL

Thursday, March 22 | 5:00PM - 7:30PM
New Facets of NF-kappaB/IKK Signaling
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 1 of 7
* Michael J. Eck, Dana Farber Cancer Institute, USA


Thursday, March 22 | 5:00PM - 7:30PM
New Facets of NF-kappaB/IKK Signaling
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 2 of 7
Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany
NF-kappaB and DNA Damage


Thursday, March 22 | 5:00PM - 7:30PM
New Facets of NF-kappaB/IKK Signaling
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 3 of 7
David Wallach, Weizmann Institute of Science, Israel
The ‘Apoptotic’ Caspases as Regulators of Inflammation: New Lessons about Caspase-8 Function


Thursday, March 22 | 5:00PM - 7:30PM
New Facets of NF-kappaB/IKK Signaling
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 4 of 7
Dongsheng Cai, Albert Einstein College of Medicine, USA
Brain NF-kappaB and Metabolic Diseases


Thursday, March 22 | 5:00PM - 7:30PM
New Facets of NF-kappaB/IKK Signaling
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 5 of 7
Daniel Panne, European Molecular Biology Laboratory, France
Short Talk: Structure and Mechanism of Regulation of IKK Kinases


Thursday, March 22 | 5:00PM - 7:30PM
New Facets of NF-kappaB/IKK Signaling
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 6 of 7
Erin C. Dueber, Genentech, USA
Short Talk: Molecular Basis of TBK1 Activation by Trans-Autophosphorylation


Thursday, March 22 | 5:00PM - 7:30PM
New Facets of NF-kappaB/IKK Signaling
This session is from NF-kappaB
Room: Sea to Sky C

Speaker 7 of 7
Smarajit Polley, University of California, San Diego, USA
Short Talk: X-Ray Crystal Structure of the Human IKK2 in an Active Conformation


Thursday, March 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Thursday, March 22 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A


Thursday, March 22 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Friday, March 23 | 10:25AM - 10:25AM
Departure


*Session Chair.