Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
	Ubiquitin Signaling (2018A8)
Ubiquitin Signaling (2016X3)
The Ubiquitin System: From Basic Science to Drug Discovery (2014A2)

Web Desc
Ubiquitin Signaling joint with NF-kappaB Signaling and Biology: From Bench to Bedside Organizer(s): Ivan Dikic and Raymond J. Deshaies Date: March 18 - 23, 2012 Location: Whistler Conference Centre, Whistler, BC, Canada Supported by the Directors' Fund Summary of Meeting: Post-translational modifications of cellular proteins by ubiquitin and ubiquitin-like modifiers regulate a variety of functions in the cell. A crucial aspect of signaling through ubiquitin and Ubls is the presence of modular binding domains that recognize particular types of ubiquitin signals. Such molecular coupling creates an attractive “decoding” mechanism for responding to alterations in the cellular microenvironment and regulating physiological and pathophysiological conditions. In this meeting, we will discuss the major challenges in the field including detection of endogenous ubiquitination events, functional aspects of novel types of ubiquitin chains and their recognition by selective binding domains, and high-throughput technologies for comprehensive analysis of Ub modifications. The intersection between the deregulated ubiquitin signaling, pathogenesis of human diseases and therapies targeting the Ub system will be explored. The program offers a possibility for young scientists to present their own work and engage in discussions on the emerging topics in the field. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on NF-kB Signaling and Biology: From Bench to Bedside, which will share a keynote address and three plenary sessions with this meeting. Scholarship Deadline: November 16 2011 Discounted Abstract Deadline: November 16 2011 Abstract Deadline: December 20 2011 Discounted Registration Deadline: January 18 2012 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Genentech, Inc. Millennium Pharmaceuticals, Inc., The Takeda Oncology Company We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Ubiquitin Signaling

joint with NF-kappaB Signaling and Biology: From Bench to Bedside

Organizer(s): Ivan Dikic and Raymond J. Deshaies

Date: March 18 - 23, 2012
Location: Whistler Conference Centre, Whistler, BC, Canada

Supported by the Directors' Fund

Summary of Meeting:

Post-translational modifications of cellular proteins by ubiquitin and ubiquitin-like modifiers regulate a variety of functions in the cell. A crucial aspect of signaling through ubiquitin and Ubls is the presence of modular binding domains that recognize particular types of ubiquitin signals. Such molecular coupling creates an attractive “decoding” mechanism for responding to alterations in the cellular microenvironment and regulating physiological and pathophysiological conditions. In this meeting, we will discuss the major challenges in the field including detection of endogenous ubiquitination events, functional aspects of novel types of ubiquitin chains and their recognition by selective binding domains, and high-throughput technologies for comprehensive analysis of Ub modifications. The intersection between the deregulated ubiquitin signaling, pathogenesis of human diseases and therapies targeting the Ub system will be explored. The program offers a possibility for young scientists to present their own work and engage in discussions on the emerging topics in the field. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on NF-kB Signaling and Biology: From Bench to Bedside, which will share a keynote address and three plenary sessions with this meeting.

Scholarship Deadline: November 16 2011

Discounted Abstract Deadline: November 16 2011

Abstract Deadline: December 20 2011

Discounted Registration Deadline: January 18 2012

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

Millennium Pharmaceuticals, Inc., The Takeda Oncology Company

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 18 \| 3:00PM - 7:30PM Registration Room: Grand Foyer
Sunday, March 18 \| 6:15PM - 7:15PM Refreshments Room: Grand Foyer
Sunday, March 18 \| 7:15PM - 9:30PM Welcome and Keynote Session (Joint) Room: Sea to Sky B/C Speaker 1 of 4 * Michael Karin, University of California, San Diego, USA
Sunday, March 18 \| 7:15PM - 9:30PM Welcome and Keynote Session (Joint) Room: Sea to Sky B/C Speaker 2 of 4 David Baltimore, California Institute of Technology, USA 25 Years of the NF-kappaB Pathway
Sunday, March 18 \| 7:15PM - 9:30PM Welcome and Keynote Session (Joint) Room: Sea to Sky B/C Speaker 3 of 4 * Ivan Dikic, Goethe University Medical School, Germany
Sunday, March 18 \| 7:15PM - 9:30PM Welcome and Keynote Session (Joint) Room: Sea to Sky B/C Speaker 4 of 4 Aaron J. Ciechanover, Technion-Israel Institute of Technology, Israel The Ubiquitin Proteolytic System: From Basic Mechanisms through Human Diseases and on to Drug Targeting
Monday, March 19 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky A
Monday, March 19 \| 8:00AM - 11:15AM Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint ) Room: Sea to Sky B/C Speaker 1 of 8 * Claudio A. P. Joazeiro, University of Heidelberg, Germany
Monday, March 19 \| 8:00AM - 11:15AM Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint ) Room: Sea to Sky B/C Speaker 2 of 8 * Henning Walczak, University College London, Cancer Institute, UK
Monday, March 19 \| 8:00AM - 11:15AM Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint ) Room: Sea to Sky B/C Speaker 3 of 8 Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA Ubiquitin Signaling in the RIG-I Antiviral Pathway
Monday, March 19 \| 8:00AM - 11:15AM Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint ) Room: Sea to Sky B/C Speaker 4 of 8 Hao Wu, Harvard Medical School, Boston Children's Hospital, USA Structural and Functional Analyses of NF-kappaB and Cell Death Signaling
Monday, March 19 \| 8:00AM - 11:15AM Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint ) Room: Sea to Sky B/C Speaker 5 of 8 Domagoj Vucic, Genentech, Inc., USA Short Talk: IAP Antagonists and TNF Receptors Differentially Regulate C-IAP Ubiquitin Ligase Activity
Monday, March 19 \| 8:00AM - 11:15AM Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint ) Room: Sea to Sky B/C Speaker 6 of 8 Ivan Dikic, Goethe University Medical School, Germany Ubiquitin Networks in Regulation of NF-kappB Activation
Monday, March 19 \| 8:00AM - 11:15AM Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint ) Room: Sea to Sky B/C Speaker 7 of 8 Kazuhiro Iwai, Osaka University, Japan Linear Polyubiquitination: A Crucial Regulator of NF-kappaB Signaling
Monday, March 19 \| 8:00AM - 11:15AM Ubiquitin-Dependent Signaling in NF-kappaB Activation (Joint ) Room: Sea to Sky B/C Speaker 8 of 8 Katrin E. Rittinger, Francis Crick Institute, UK Short Talk: Mechanism of Linear Ubiquitin Chain Formation by the E3 Ligase Ccomplex LUBAC
Monday, March 19 \| 9:20AM - 9:40AM Coffee Break Room: Grand Foyer
Monday, March 19 \| 11:15AM - 1:00PM Poster Setup Room: Sea to Sky A
Monday, March 19 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Monday, March 19 \| 1:00PM - 10:00PM Poster Viewing Room: Sea to Sky A
Monday, March 19 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Monday, March 19 \| 5:00PM - 7:00PM Ubiquitin Conjugation/Deconjugation Machineries Room: Sea to Sky B Speaker 1 of 6 * Scott D. Emr, Cornell University, USA
Monday, March 19 \| 5:00PM - 7:00PM Ubiquitin Conjugation/Deconjugation Machineries Room: Sea to Sky B Speaker 2 of 6 * Jon Huibregtse, University of Texas at Austin, USA
Monday, March 19 \| 5:00PM - 7:00PM Ubiquitin Conjugation/Deconjugation Machineries Room: Sea to Sky B Speaker 3 of 6 Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany Structural Biology of E3 Ubiquitin Ligase Enzymes
Monday, March 19 \| 5:00PM - 7:00PM Ubiquitin Conjugation/Deconjugation Machineries Room: Sea to Sky B Speaker 4 of 6 Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research, Switzerland Short Talk: CRL4CSA/DDB2 Ubiquitin Ligase Architecture, Targeting to Chromatin and Cop9 Signalosome Mediated Regulation
Monday, March 19 \| 5:00PM - 7:00PM Ubiquitin Conjugation/Deconjugation Machineries Room: Sea to Sky B Speaker 5 of 6 Claudio A. P. Joazeiro, University of Heidelberg, Germany Listerin/Ltn1, an E3 Ligase Implicated in Neurodegeneration, Mediates a Novel Pathway of Cytoplasmic Protein Quality Control
Monday, March 19 \| 5:00PM - 7:00PM Ubiquitin Conjugation/Deconjugation Machineries Room: Sea to Sky B Speaker 6 of 6 Keith D. Wilkinson, Emory University, USA Roles of the BAP1 Deubiquitinating Enzyme in Tumor Suppression
Monday, March 19 \| 5:00PM - 7:00PM NF-kappaB and Transcription This session is from NF-kappaB Room: Sea to Sky C Speaker 1 of 6 * Thomas D. Gilmore, Boston University, USA
Monday, March 19 \| 5:00PM - 7:00PM NF-kappaB and Transcription This session is from NF-kappaB Room: Sea to Sky C Speaker 2 of 6 Alexander Hoffmann, University of California, Los Angeles, USA NF-kappaB Functions within the Pathogen-Responsive Gene Regulatory Network
Monday, March 19 \| 5:00PM - 7:00PM NF-kappaB and Transcription This session is from NF-kappaB Room: Sea to Sky C Speaker 3 of 6 Stephen T. Smale, University of California, Los Angeles, USA Transcriptional Specificity of an NF-kappaB Response
Monday, March 19 \| 5:00PM - 7:00PM NF-kappaB and Transcription This session is from NF-kappaB Room: Sea to Sky C Speaker 4 of 6 Ruaidhrí John Carmody, University College Cork, Ireland Short Talk: De-Ubiquitination of NF-kappaB by Ubiquitin-Specific Protease-7 Promotes Transcription
Monday, March 19 \| 5:00PM - 7:00PM NF-kappaB and Transcription This session is from NF-kappaB Room: Sea to Sky C Speaker 5 of 6 Sulakshana P. Mukherjee, University of California, San Diego, USA Short Talk: Insights into the RelA:CBP Interaction in Transcription Regulation
Monday, March 19 \| 5:00PM - 7:00PM NF-kappaB and Transcription This session is from NF-kappaB Room: Sea to Sky C Speaker 6 of 6 Matthew E. Pipkin, The Scripps Research Institute, USA Short Talk: NFAT Transcription Factors Control Transcriptional Elongation in Memory CD8 T Cells
Monday, March 19 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Sea to Sky A
Monday, March 19 \| 7:30PM - 10:00PM Poster Session 1 Room: Sea to Sky A
Tuesday, March 20 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky A
Tuesday, March 20 \| 8:00AM - 11:15AM Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi nt) Room: Sea to Sky B/C Speaker 1 of 8 * J. Wade Harper, Harvard Medical School, USA
Tuesday, March 20 \| 8:00AM - 11:15AM Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi nt) Room: Sea to Sky B/C Speaker 2 of 8 * Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Tuesday, March 20 \| 8:00AM - 11:15AM Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi nt) Room: Sea to Sky B/C Speaker 3 of 8 Margot Thome, University of Lausanne, Switzerland Role of the MALT1 Protease Activity in Adaptive Immunity and Lymphoma
Tuesday, March 20 \| 8:00AM - 11:15AM Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi nt) Room: Sea to Sky B/C Speaker 4 of 8 Sarah Spiegel, Virginia Commonwealth University, USA Regulation of RING E3 Ubiquitin Ligases by Sphingosine-1-Phosphate
Tuesday, March 20 \| 8:00AM - 11:15AM Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi nt) Room: Sea to Sky B/C Speaker 5 of 8 Kristopher Clark, University of Dundee, UK Short Talk: Cross-Talk within the IkappaB Kinase Family is Required to Limit NF-kappaB Signaling and Prevent Autoimmunity
Tuesday, March 20 \| 8:00AM - 11:15AM Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi nt) Room: Sea to Sky B/C Speaker 6 of 8 Michael Karin, University of California, San Diego, USA Ub Cascades in Innate Immunity
Tuesday, March 20 \| 8:00AM - 11:15AM Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi nt) Room: Sea to Sky B/C Speaker 7 of 8 Vishva M. Dixit, Genentech, Inc., USA Regulation of Pro-Inflammatory Receptor Signaling by Ubiquitin Hydrolases
Tuesday, March 20 \| 8:00AM - 11:15AM Innate and Adaptive Immunity and Ub-Dependent Signaling (Joi nt) Room: Sea to Sky B/C Speaker 8 of 8 Henning Walczak, University College London, Cancer Institute, UK Short Talk: Linear Ubiquitination in Cell Death, Inflammation and Immunity
Tuesday, March 20 \| 9:20AM - 9:40AM Coffee Break Room: Grand Foyer
Tuesday, March 20 \| 11:15AM - 1:00PM Poster Setup Room: Sea to Sky A
Tuesday, March 20 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Tuesday, March 20 \| 1:00PM - 10:00PM Poster Viewing Room: Sea to Sky A
Tuesday, March 20 \| 2:30PM - 4:30PM Workshop 1: NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 1 of 9 * Manolis Pasparakis, University of Cologne, Germany
Tuesday, March 20 \| 2:30PM - 4:30PM Workshop 1: NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 2 of 9 Dirk Brenner, Luxembourg Institute of Health, Luxembourg MALT1 is Indispensable for an Inflammatory Th17 Cell Response
Tuesday, March 20 \| 2:30PM - 4:30PM Workshop 1: NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 3 of 9 Thomas D. Gilmore, Boston University, USA Evolutionary Origins of NF-kappaB Signaling
Tuesday, March 20 \| 2:30PM - 4:30PM Workshop 1: NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 4 of 9 Christopher C. Goodnow, Garvan Institute of Medical Research, Australia CARD11 Lymphoma Mutations Switch Self-Antigen Induced B Cell Death into Growth
Tuesday, March 20 \| 2:30PM - 4:30PM Workshop 1: NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 5 of 9 Marie Anne O'Donnell, Rockefeller, USA CASPASE 8 is a Dexterous Killer with a Heart
Tuesday, March 20 \| 2:30PM - 4:30PM Workshop 1: NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 6 of 9 Michael J. May, University of Pennsylvania, USA A Novel Role for cIAPs in IkappaBepsilon Degradation
Tuesday, March 20 \| 2:30PM - 4:30PM Workshop 1: NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 7 of 9 Fabrice Agou, Institut Pasteur, France Two-Sided Ubiquitin Binding Explains the EDA-ID-Related Mutations of NEMO ZF
Tuesday, March 20 \| 2:30PM - 4:30PM Workshop 1: NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 8 of 9 Steven C. Ley, Francis Crick Institute, UK Regulation of Immune Responses by IKK-Induced NF-kappaB1 p105 Proteolysis
Tuesday, March 20 \| 2:30PM - 4:30PM Workshop 1: NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 9 of 9 Carolyn Gray, University of Pennsylvania, USA A Role for NEMO in the Non-Canonical NF-kappaB Signaling Pathway
Tuesday, March 20 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Tuesday, March 20 \| 5:00PM - 7:00PM Ubiquitin Chains and Ubiquitin-Binding Domains (UBDs) Room: Sea to Sky B Speaker 1 of 6 * Keith D. Wilkinson, Emory University, USA
Tuesday, March 20 \| 5:00PM - 7:00PM Ubiquitin Chains and Ubiquitin-Binding Domains (UBDs) Room: Sea to Sky B Speaker 2 of 6 * Eilika Weber-Ban, ETH Zürich, Switzerland
Tuesday, March 20 \| 5:00PM - 7:00PM Ubiquitin Chains and Ubiquitin-Binding Domains (UBDs) Room: Sea to Sky B Speaker 3 of 6 Kay Hofmann, University of Cologne, Germany Bioinformatical Discovery and Characterization of Ubiquitin-Binding Domains
Tuesday, March 20 \| 5:00PM - 7:00PM Ubiquitin Chains and Ubiquitin-Binding Domains (UBDs) Room: Sea to Sky B Speaker 4 of 6 Michael Rape, University of California, Berkeley, USA Function and Assembly of Lysine 11-Linked Ubiquitin Chains
Tuesday, March 20 \| 5:00PM - 7:00PM Ubiquitin Chains and Ubiquitin-Binding Domains (UBDs) Room: Sea to Sky B Speaker 5 of 6 Scott D. Emr, Cornell University, USA Ubiquitin-Mediated Endocytosis and Down-Regulation of PM Proteins
Tuesday, March 20 \| 5:00PM - 7:00PM Ubiquitin Chains and Ubiquitin-Binding Domains (UBDs) Room: Sea to Sky B Speaker 6 of 6 Andreas Ernst, University of Toronto, Canada Short Talk: A General Strategy to Generate Inhibitors of the Ubiquitin System
Tuesday, March 20 \| 5:00PM - 7:00PM NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 1 of 4 * Alexander Hoffmann, University of California, Los Angeles, USA
Tuesday, March 20 \| 5:00PM - 7:00PM NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 2 of 4 Takashi Fujita, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan Antiviral Innate Immunity: Control of Interferon Production
Tuesday, March 20 \| 5:00PM - 7:00PM NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 3 of 4 Paulina A. Bartuzi, University Medical Center Groningen, Netherlands Short Talk: Hepatic Depletion of Commd1 Ameliorates Liver Inflammation in a Mouse Model of Non-Alcoholic Steatohepatitis
Tuesday, March 20 \| 5:00PM - 7:00PM NF-kappaB in Inflammation and Immunity This session is from NF-kappaB Room: Sea to Sky C Speaker 4 of 4 Steve D. Gerondakis, Monash University, Australia Short Talk: c-Rel Controls Multiple Steps in the Development of Thymic CD4 Regulatory T Cells
Tuesday, March 20 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Sea to Sky A
Tuesday, March 20 \| 7:30PM - 10:00PM Poster Session 2 Room: Sea to Sky A
Wednesday, March 21 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky A
Wednesday, March 21 \| 8:00AM - 11:15AM Ubiquitin Signaling and Diseases Room: Sea to Sky B Speaker 1 of 8 * Raymond J. Deshaies, Amgen, Inc., USA
Wednesday, March 21 \| 8:00AM - 11:15AM Ubiquitin Signaling and Diseases Room: Sea to Sky B Speaker 2 of 8 * Mary C. Dasso, National Institutes of Health, NICHD, USA
Wednesday, March 21 \| 8:00AM - 11:15AM Ubiquitin Signaling and Diseases Room: Sea to Sky B Speaker 3 of 8 Karen H. Vousden, Francis Crick Institute, UK Ubiquitin Signaling in the Regulation of p53
Wednesday, March 21 \| 8:00AM - 11:15AM Ubiquitin Signaling and Diseases Room: Sea to Sky B Speaker 4 of 8 Agata Smogorzewska, Rockefeller University, USA Ubiquitin Signaling in DNA Damage and Repair
Wednesday, March 21 \| 8:00AM - 11:15AM Ubiquitin Signaling and Diseases Room: Sea to Sky B Speaker 5 of 8 Mads Daugaard, University of British Columbia, Canada Short Talk: The Hace1 E3 Ligase Blocks NADPH Oxidase Generation of Superoxide by Targeting Rac1 for Proteasomal Degradation
Wednesday, March 21 \| 8:00AM - 11:15AM Ubiquitin Signaling and Diseases Room: Sea to Sky B Speaker 6 of 8 Pier Paolo Di Fiore, FIRC Institute of Molecular Oncology, Italy Ubiquitin Pathways in Stem Cells
Wednesday, March 21 \| 8:00AM - 11:15AM Ubiquitin Signaling and Diseases Room: Sea to Sky B Speaker 7 of 8 Judith Frydman, Stanford University, USA Protein Aggregation and Neurodegeneration
Wednesday, March 21 \| 8:00AM - 11:15AM Ubiquitin Signaling and Diseases Room: Sea to Sky B Speaker 8 of 8 Andreas Martin, University of California, Berkeley, USA Short Talk: Complete Subunit Architecture of the 26S Proteasome Reveals Mechanisms of Ubiquitin-Dependent Substrate Degradation
Wednesday, March 21 \| 8:00AM - 11:30AM Cell Death Signaling and Its Regulation by Ubiquitin and NF- kappaB This session is from NF-kappaB Room: Sea to Sky C Speaker 1 of 8 * Domagoj Vucic, Genentech, Inc., USA
Wednesday, March 21 \| 8:00AM - 11:30AM Cell Death Signaling and Its Regulation by Ubiquitin and NF- kappaB This session is from NF-kappaB Room: Sea to Sky C Speaker 2 of 8 Francis Ka-Ming Chan, Duke University, USA Regulation of Cell Death and Cell Survival by the RIP Kinases
Wednesday, March 21 \| 8:00AM - 11:30AM Cell Death Signaling and Its Regulation by Ubiquitin and NF- kappaB This session is from NF-kappaB Room: Sea to Sky C Speaker 3 of 8 Ingrid E. Wertz, Genentech, Inc., USA Molecular Mechanisms of NF-kappaB Regulation by the Ubiquitin Editing Enzyme A20
Wednesday, March 21 \| 8:00AM - 11:30AM Cell Death Signaling and Its Regulation by Ubiquitin and NF- kappaB This session is from NF-kappaB Room: Sea to Sky C Speaker 4 of 8 Genhong Cheng, University of California, Los Angeles, USA TRAF3 at the Crossroads of Antiviral and Inflammatory Responses
Wednesday, March 21 \| 8:00AM - 11:30AM Cell Death Signaling and Its Regulation by Ubiquitin and NF- kappaB This session is from NF-kappaB Room: Sea to Sky C Speaker 5 of 8 Zheng gang Liu, NCI, National Institutes of Health, USA Understanding the Regulation of TNF-Induced Cell Death
Wednesday, March 21 \| 8:00AM - 11:30AM Cell Death Signaling and Its Regulation by Ubiquitin and NF- kappaB This session is from NF-kappaB Room: Sea to Sky C Speaker 6 of 8 Andrew Oberst, University of Washington, USA Short Talk: Cooperation of FADD, Caspase-8, and FLIP is Required to Prevent RIPK3-Dependent Programmed Necrosis during Embryonic Development
Wednesday, March 21 \| 8:00AM - 11:30AM Cell Death Signaling and Its Regulation by Ubiquitin and NF- kappaB This session is from NF-kappaB Room: Sea to Sky C Speaker 7 of 8 Anning Lin, Shanghai Institute of Biochemistry and Cell Biology, China Short Talk: Novel Signaling by the IKK Complex
Wednesday, March 21 \| 8:00AM - 11:30AM Cell Death Signaling and Its Regulation by Ubiquitin and NF- kappaB This session is from NF-kappaB Room: Sea to Sky C Speaker 8 of 8 Seda Çöl Arslan, Max Delbrück Center for Molecular Medicine, Germany Short Talk: TAK1-RIP1 Interplay Determines the Prevalence of TNFalpha-Induced Programmed Necrosis over Apoptosis
Wednesday, March 21 \| 9:20AM - 9:40AM Coffee Break Room: Grand Foyer
Wednesday, March 21 \| 11:15AM - 1:00PM Poster Setup Room: Sea to Sky A
Wednesday, March 21 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Wednesday, March 21 \| 1:00PM - 10:00PM Poster Viewing Room: Sea to Sky A
Wednesday, March 21 \| 1:30PM - 3:00PM Workshop 1: Novel Techniques to Track Ub Signals Room: Sea to Sky B Speaker 1 of 7 * Steven P. Gygi, Harvard Medical School, USA
Wednesday, March 21 \| 1:30PM - 3:00PM Workshop 1: Novel Techniques to Track Ub Signals Room: Sea to Sky B Speaker 2 of 7 * Ingrid E. Wertz, Genentech, Inc., USA
Wednesday, March 21 \| 1:30PM - 3:00PM Workshop 1: Novel Techniques to Track Ub Signals Room: Sea to Sky B Speaker 3 of 7 Eric J. Bennett, University of California, San Diego, USA Monitoring Proteome Fidelity through Quantitative Analysis of Endogenous Ubiquitin Targets
Wednesday, March 21 \| 1:30PM - 3:00PM Workshop 1: Novel Techniques to Track Ub Signals Room: Sea to Sky B Speaker 4 of 7 Bradley B. Brasher, Boston Biochem, Inc., USA Non-Hydrolyzable Polyubiquitin Chains: Development and Characterization of New Reagents for Signal Transduction Studies
Wednesday, March 21 \| 1:30PM - 3:00PM Workshop 1: Novel Techniques to Track Ub Signals Room: Sea to Sky B Speaker 5 of 7 Arno F. Alpi, University of Dundee, UK Regulation of Cullin Neddylation by the Ariadne Subfamily of RING-in-between-RING E3 Ubiquitin Ligases
Wednesday, March 21 \| 1:30PM - 3:00PM Workshop 1: Novel Techniques to Track Ub Signals Room: Sea to Sky B Speaker 6 of 7 Simon Bekker-Jensen, University of Copenhagen, Denmark Ubiquitin-Dependent Regulation of PAF15 Promotes Cellular Responses to Replication Blocks
Wednesday, March 21 \| 1:30PM - 3:00PM Workshop 1: Novel Techniques to Track Ub Signals Room: Sea to Sky B Speaker 7 of 7 Fumiyo Ikeda, IMBA – Institute of Molecular Biotechnology, Austria Sharpin-Dependent Linear-Ubiquitination is Required for Cell Survival Pathway
Wednesday, March 21 \| 3:00PM - 4:30PM Workshop 2: Disease Models and Novel Therapies Room: Sea to Sky B Speaker 1 of 7 * Karen H. Vousden, Francis Crick Institute, UK
Wednesday, March 21 \| 3:00PM - 4:30PM Workshop 2: Disease Models and Novel Therapies Room: Sea to Sky B Speaker 2 of 7 * Teresa Soucy, Millennium Pharmaceuticals, Inc., USA
Wednesday, March 21 \| 3:00PM - 4:30PM Workshop 2: Disease Models and Novel Therapies Room: Sea to Sky B Speaker 3 of 7 Valentina Perissi, Boston University School of Medicine, USA A Protective Strategy against Hyper-Inflammatory Responses Requiring GPS2 Inhibition of TRAF2 Enzymatic Activity
Wednesday, March 21 \| 3:00PM - 4:30PM Workshop 2: Disease Models and Novel Therapies Room: Sea to Sky B Speaker 4 of 7 Koraljka Husnjak, Institute of Biochemistry II, Germany Elucidating the Role of Proteasomal Ubiquitin Receptor Rpn13 in Growth and Development
Wednesday, March 21 \| 3:00PM - 4:30PM Workshop 2: Disease Models and Novel Therapies Room: Sea to Sky B Speaker 5 of 7 Lynn Boyden, Yale University School of Medicine, USA Mutations in Kelch-Like 3 and Cullin 3 Implicate Ubiquitination in Regulation of Electrolyte Homeostasis and Blood Pressure
Wednesday, March 21 \| 3:00PM - 4:30PM Workshop 2: Disease Models and Novel Therapies Room: Sea to Sky B Speaker 6 of 7 Mads Gyrd-Hansen, University of Oxford, UK XIAP Ubiquitylates RIPK2 and Recruits LUBAC to Regulate Innate Immune Signaling
Wednesday, March 21 \| 3:00PM - 4:30PM Workshop 2: Disease Models and Novel Therapies Room: Sea to Sky B Speaker 7 of 7 Marene Landstrom, Umeå University, Sweden The Molecular Mechanisms which Determines how TGF-beta Can Act as a Tumor Promoter
Wednesday, March 21 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Wednesday, March 21 \| 5:00PM - 7:00PM Proteome Analysis of Ub System Room: Sea to Sky B Speaker 1 of 6 * Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Wednesday, March 21 \| 5:00PM - 7:00PM Proteome Analysis of Ub System Room: Sea to Sky B Speaker 2 of 6 * Pier Paolo Di Fiore, FIRC Institute of Molecular Oncology, Italy
Wednesday, March 21 \| 5:00PM - 7:00PM Proteome Analysis of Ub System Room: Sea to Sky B Speaker 3 of 6 Lan Huang, University of California, Irvine, USA Understanding the Ubiquitin-Proteasome System by Probing Protein-Protein Interactions
Wednesday, March 21 \| 5:00PM - 7:00PM Proteome Analysis of Ub System Room: Sea to Sky B Speaker 4 of 6 J. Wade Harper, Harvard Medical School, USA Proteomic Exploration of the Ubiquitin System
Wednesday, March 21 \| 5:00PM - 7:00PM Proteome Analysis of Ub System Room: Sea to Sky B Speaker 5 of 6 Steven P. Gygi, Harvard Medical School, USA Analyzing the Ubiquitin-Modified Proteome
Wednesday, March 21 \| 5:00PM - 7:00PM Proteome Analysis of Ub System Room: Sea to Sky B Speaker 6 of 6 Thibault Mayor, University of British Columbia, Canada Short Talk: Systems-Wide Analysis Reveals that Low Abundant Disordered Proteins are Prone to Ubiquitylation after Misfolding Stress
Wednesday, March 21 \| 5:00PM - 7:15PM NF-kappaB and Disease This session is from NF-kappaB Room: Sea to Sky C Speaker 1 of 6 * Alain Israël, Institut Pasteur, France
Wednesday, March 21 \| 5:00PM - 7:15PM NF-kappaB and Disease This session is from NF-kappaB Room: Sea to Sky C Speaker 2 of 6 Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel NF-kappaB in Cancer
Wednesday, March 21 \| 5:00PM - 7:15PM NF-kappaB and Disease This session is from NF-kappaB Room: Sea to Sky C Speaker 3 of 6 Manolis Pasparakis, University of Cologne, Germany IKK/NF-kappaB Signaling in Epithelial Homeostasis and Inflammation
Wednesday, March 21 \| 5:00PM - 7:15PM NF-kappaB and Disease This session is from NF-kappaB Room: Sea to Sky C Speaker 4 of 6 Jean-Laurent Casanova, Rockefeller University, USA Life-Threatening Infectious Diseases of Childhood: Single-Gene Inborn Errors of Immunity?
Wednesday, March 21 \| 5:00PM - 7:15PM NF-kappaB and Disease This session is from NF-kappaB Room: Sea to Sky C Speaker 5 of 6 Ethel Cesarman, Weill Cornell Medical College, USA Short Talk: Central Role of vFLIP-Induced NF-kappaB in the Pathobiology of KSHV-Associated Malignancies
Wednesday, March 21 \| 5:00PM - 7:15PM NF-kappaB and Disease This session is from NF-kappaB Room: Sea to Sky C Speaker 6 of 6 Vasant Chellappa, Massachusetts General Hospital, USA Short Talk: Somatic Mutations of RIPK4/PKK Drive NF-kappaB Dependent Cancers while Germline Variants Compromise NF-kappaB Signaling in an Inherited Syndrome Involving Defective Epidermal Differentiation
Wednesday, March 21 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Sea to Sky A
Wednesday, March 21 \| 7:30PM - 10:00PM Poster Session 3 Room: Sea to Sky A
Thursday, March 22 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky A
Thursday, March 22 \| 8:00AM - 11:15AM Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th erapy (Joint) Room: Sea to Sky B/C Speaker 1 of 7 * Michael Rape, University of California, Berkeley, USA
Thursday, March 22 \| 8:00AM - 11:15AM Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th erapy (Joint) Room: Sea to Sky B/C Speaker 2 of 7 Raymond J. Deshaies, Amgen, Inc., USA Prospecting for Drug Targets in the Ubiquitin-Proteasome System
Thursday, March 22 \| 8:00AM - 11:15AM Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th erapy (Joint) Room: Sea to Sky B/C Speaker 3 of 7 Teresa Soucy, Millennium Pharmaceuticals, Inc., USA Mechanism-Based E1 Inhibitors Offer New Insights into Ubiquitin-Like Protein Conjugation
Thursday, March 22 \| 8:00AM - 11:15AM Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th erapy (Joint) Room: Sea to Sky B/C Speaker 4 of 7 Daniel Krappmann, Helmholtz Zentrum München, Germany Short Talk: Targeting the NEMO-Ubiquitin Interface with Small Molecules - New Strategy for the Design of Pharmacological NF-kappaB Inhibitors
Thursday, March 22 \| 8:00AM - 11:15AM Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th erapy (Joint) Room: Sea to Sky B/C Speaker 5 of 7 Alain Israël, Institut Pasteur, France Human Pathology Associated with Deficiency in HOIL-1, One of the Components of the LUBAC Ubiquitin Ligase Complex
Thursday, March 22 \| 8:00AM - 11:15AM Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th erapy (Joint) Room: Sea to Sky B/C Speaker 6 of 7 Philip Cohen, University of Dundee, UK Novel Cross-Talk within the IKK Family Controls Signaling to NF-kappaB
Thursday, March 22 \| 8:00AM - 11:15AM Ubiquitin Dependent Signaling to NF-kappaB in Disease and Th erapy (Joint) Room: Sea to Sky B/C Speaker 7 of 7 Neal Silverman, University of Massachusetts Medical School, USA Short Talk: Caspase Mediated Cleavage, IAP Binding and Ubiquitination Drive Drosophila NF-kappaB Signaling
Thursday, March 22 \| 9:00AM - 9:20AM Coffee Break Room: Grand Foyer
Thursday, March 22 \| 11:00AM - 11:00AM On Own for Lunch and Recreation
Thursday, March 22 \| 2:30PM - 4:30PM Workshop 2: NF-kappaB in Cancer and Other Diseases This session is from NF-kappaB Room: Sea to Sky C Speaker 1 of 9 * Francis Ka-Ming Chan, Duke University, USA
Thursday, March 22 \| 2:30PM - 4:30PM Workshop 2: NF-kappaB in Cancer and Other Diseases This session is from NF-kappaB Room: Sea to Sky C Speaker 2 of 9 Bernd Baumann, University of Ulm, Germany beta-Cell Specific Changes in IKK/NF-kappaB Signaling Interfere with beta-Cell Homeostasis and Result in Diabetes-Like Phenotypes
Thursday, March 22 \| 2:30PM - 4:30PM Workshop 2: NF-kappaB in Cancer and Other Diseases This session is from NF-kappaB Room: Sea to Sky C Speaker 3 of 9 Katy Billot, INSERM U1016 Institut Cochin, France RelB Inhibits Cell Proliferation and Tumor Growth through p53 Transcriptional Activation
Thursday, March 22 \| 2:30PM - 4:30PM Workshop 2: NF-kappaB in Cancer and Other Diseases This session is from NF-kappaB Room: Sea to Sky C Speaker 4 of 9 Brent Cameron, Case Western Reserve University, USA Loss of IRAK4 Function Alters Microglial Response and Enhances Clearance of Abeta from the Brain in an Alzheimer’s Disease Mouse Model
Thursday, March 22 \| 2:30PM - 4:30PM Workshop 2: NF-kappaB in Cancer and Other Diseases This session is from NF-kappaB Room: Sea to Sky C Speaker 5 of 9 Carter Van Waes, NIDCD, National Institutes of Health, USA Novel c-REL/RELA Interactions with deltaNp63alpha Dysregulate NF-kappaB and p73 Target Genes in Head and Neck Cancer
Thursday, March 22 \| 2:30PM - 4:30PM Workshop 2: NF-kappaB in Cancer and Other Diseases This session is from NF-kappaB Room: Sea to Sky C Speaker 6 of 9 Bryant G. Darnay, University of Texas MD Anderson Cancer Center, USA New Genetic Lesion Identified in AML Revealed by a Mouse Model for Myeloid-Specific Deletion of TAK1
Thursday, March 22 \| 2:30PM - 4:30PM Workshop 2: NF-kappaB in Cancer and Other Diseases This session is from NF-kappaB Room: Sea to Sky C Speaker 7 of 9 Jean-Pierre Julien, Université Laval, Canada TDP-43 Drives NF-kappaB-Mediated Pathogenic Pathways in Amyotrophic Lateral Sclerosis
Thursday, March 22 \| 2:30PM - 4:30PM Workshop 2: NF-kappaB in Cancer and Other Diseases This session is from NF-kappaB Room: Sea to Sky C Speaker 8 of 9 Alessandra Agresti, San Raffaele Scientific Institute, Italy Smart Drugs to Counteract NF-kappaB Driven Proliferation in Multiple Myeloma
Thursday, March 22 \| 2:30PM - 4:30PM Workshop 2: NF-kappaB in Cancer and Other Diseases This session is from NF-kappaB Room: Sea to Sky C Speaker 9 of 9 Brian C. Schaefer, Uniformed Services University, USA Selective Autophagy of Bcl10 Modulates T Cell Receptor Activation of NF-kappaB – New Targets for Intervention in Lymphocyte Cancers and Lymphocyte Functional Responses
Thursday, March 22 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Thursday, March 22 \| 5:00PM - 7:00PM Ubiquitin-Like Modifiers in Signaling Room: Sea to Sky B Speaker 1 of 6 * Agata Smogorzewska, Rockefeller University, USA
Thursday, March 22 \| 5:00PM - 7:00PM Ubiquitin-Like Modifiers in Signaling Room: Sea to Sky B Speaker 2 of 6 * Kay Hofmann, University of Cologne, Germany
Thursday, March 22 \| 5:00PM - 7:00PM Ubiquitin-Like Modifiers in Signaling Room: Sea to Sky B Speaker 3 of 6 Mary C. Dasso, National Institutes of Health, NICHD, USA Regulation of Ribosome Biogenesis through the deSUMOylating Enzyme SENP3
Thursday, March 22 \| 5:00PM - 7:00PM Ubiquitin-Like Modifiers in Signaling Room: Sea to Sky B Speaker 4 of 6 Eilika Weber-Ban, ETH Zürich, Switzerland Pupylation – Ubiquitin-Like Pathway in Bacteria
Thursday, March 22 \| 5:00PM - 7:00PM Ubiquitin-Like Modifiers in Signaling Room: Sea to Sky B Speaker 5 of 6 Jon Huibregtse, University of Texas at Austin, USA Mechanism and Function of ISG15 Conjugation
Thursday, March 22 \| 5:00PM - 7:00PM Ubiquitin-Like Modifiers in Signaling Room: Sea to Sky B Speaker 6 of 6 Minghua Nie, The Scripps Research Institute, USA Short Talk: A Role for the Cdc48Ufd1-Npl4 Complex in the Function of STUbL
Thursday, March 22 \| 5:00PM - 7:30PM New Facets of NF-kappaB/IKK Signaling This session is from NF-kappaB Room: Sea to Sky C Speaker 1 of 7 * Michael J. Eck, Dana Farber Cancer Institute, USA
Thursday, March 22 \| 5:00PM - 7:30PM New Facets of NF-kappaB/IKK Signaling This session is from NF-kappaB Room: Sea to Sky C Speaker 2 of 7 Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany NF-kappaB and DNA Damage
Thursday, March 22 \| 5:00PM - 7:30PM New Facets of NF-kappaB/IKK Signaling This session is from NF-kappaB Room: Sea to Sky C Speaker 3 of 7 David Wallach, Weizmann Institute of Science, Israel The ‘Apoptotic’ Caspases as Regulators of Inflammation: New Lessons about Caspase-8 Function
Thursday, March 22 \| 5:00PM - 7:30PM New Facets of NF-kappaB/IKK Signaling This session is from NF-kappaB Room: Sea to Sky C Speaker 4 of 7 Dongsheng Cai, Albert Einstein College of Medicine, USA Brain NF-kappaB and Metabolic Diseases
Thursday, March 22 \| 5:00PM - 7:30PM New Facets of NF-kappaB/IKK Signaling This session is from NF-kappaB Room: Sea to Sky C Speaker 5 of 7 Daniel Panne, European Molecular Biology Laboratory, France Short Talk: Structure and Mechanism of Regulation of IKK Kinases
Thursday, March 22 \| 5:00PM - 7:30PM New Facets of NF-kappaB/IKK Signaling This session is from NF-kappaB Room: Sea to Sky C Speaker 6 of 7 Erin C. Dueber, Genentech, USA Short Talk: Molecular Basis of TBK1 Activation by Trans-Autophosphorylation
Thursday, March 22 \| 5:00PM - 7:30PM New Facets of NF-kappaB/IKK Signaling This session is from NF-kappaB Room: Sea to Sky C Speaker 7 of 7 Smarajit Polley, University of California, San Diego, USA Short Talk: X-Ray Crystal Structure of the Human IKK2 in an Active Conformation
Thursday, March 22 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Sea to Sky A
Thursday, March 22 \| 8:00PM - 11:00PM Entertainment Room: Sea to Sky A
Thursday, March 22 \| 8:00PM - 11:00PM Cash Bar Room: Sea to Sky A
Friday, March 23 \| 10:25AM - 10:25AM Departure *Session Chair.