Web Desc
Mitochondrial Dynamics and Function
joint with Cell Death Pathways: Beyond Apoptosis
Organizer(s): Luca Scorrano and Jodi Nunnari
Date: March 19 - 24, 2012
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by Takeda Pharmaceutical Company Limited
Summary of Meeting:
Mitochondria are no longer considered “only” as the cellular thermodynamic converter: mounting evidence implicates them as key organelles in cell signaling, proliferation, aging, disease and death. Indeed, our view of this organelle was profoundly altered with the discovery that mitochondria function within a connected network that is continuously remodeled by fusion and division events. This reality has sparked and accelerated new scientific discoveries through the intersection of different fields about the functional roles and molecular features of mitochondrial behaviors. The interaction between the cell death and mitochondrial dynamics fields is the best example of such interplay and has led to the discovery that modulators governing cell death and mitochondrial dynamics, respectively, are in fact interacting with one another. This Keystone Symposia meeting uniquely builds on this rich interdisciplinary interaction, which continues to provide novel insights into the mechanisms underlying mitochondrial behavior and mitochondrial-associated diseases. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Cell Death Pathways: Beyond Apoptosis, which will share a keynote address and two plenary sessions with this meeting.
Scholarship Deadline: November 17 2011
Discounted Abstract Deadline: November 17 2011
Abstract Deadline: December 21 2011
Discounted Registration Deadline: January 19 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Takeda Pharmaceutical Company Limited
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
EMBO (European Molecular Biology Organization)
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM100698-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, March 19 | 3:00PM - 7:30PM
Registration
Room: Van Horne Foyer


Monday, March 19 | 6:15PM - 7:15PM
Refreshments
Room: Van Horne Foyer


Monday, March 19 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne A-B

Speaker 1 of 4
* Luca Scorrano, University of Padova, Italy

Monday, March 19 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne A-B

Speaker 2 of 4
Heidi M. McBride, McGill University, Canada
Mitochondrial Dynamics and Quality Control

Monday, March 19 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne A-B

Speaker 3 of 4
Junying Yuan, Harvard Medical School, USA
Programmed Cell Death: From Apoptosis to Necroptosis

Monday, March 19 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne A-B

Speaker 4 of 4
* Serge Przedborski, Columbia University, USA

Tuesday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 1 of 7
* Richard J. Youle, NINDS, National Institutes of Health, USA

Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 2 of 7
Kim McCall, Boston University, USA
Mitochondrial Dynamics and Cell Death in Drosophila Oogenesis

Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 3 of 7
Luca Scorrano, University of Padova, Italy
Integrating Mitochondrial Morphology and Ultrastructure in the Control of Apoptosis: Lessons from Cellular and Mouse Models

Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 4 of 7
Seamus J. Martin, Trinity College Dublin, Ireland
Mitochondrial Quality Control and the Bcl-2 Family

Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 5 of 7
Joseph T. Opferman, St. Jude Children's Research Hospital, USA
Anti-Apoptotic MCL-1 Localizes to the Mitochondrial Matrix and Regulates Mitochondrial Function

Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 6 of 7
Michelangelo Campanella, RVC and UCL Consortium for Mitochondrial Research, UK
Short Talk: The F1FO-ATPsynthase Inhibitor IF1 Controls Apoptosis by Regulating Mitochondrial Dynamics

Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 7 of 7
Nuno Raimundo, University Medical Center Goettingen, Germany
Short Talk: Mitochondrial Stress Triggers E2F1 Apoptotic Signaling to Cause Deafness – Insights into Tissue-Specific Mechanisms

Tuesday, March 20 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Tuesday, March 20 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Tuesday, March 20 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 1 of 7
* Carol M. Troy, Columbia University Medical Center, USA


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 2 of 7
Patrick A. Lewis, University of Reading, UK
The ROC Domain of DAPK1 as a Controller of DAPK1 Function and Cell Death


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 3 of 7
Meera Nanjundan, University of South Florida, USA
Role of SnoN/SkiL in Modulating Cell Death Pathways in the Pathogenesis of Ovarian Cancer


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 4 of 7
Sho Morioka, North Carolina State University, USA
TAK1 Regulates Mitochondrial Integrity, Which Is Important for Preventing TNF-Induced Endothelial Cell Death and Vascular Development


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 5 of 7
Yuxing Zhao, St. Vincent's Institute, Australia
Apoptotic and Non-Apoptotic Pathways Lead to Pancreatic beta Cell Destruction in Type 1 Diabetes


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 6 of 7
Susan E. Brockerhoff, University of Washington, USA
Mechanisms of Photoreceptor Degeneration


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 7 of 7
Jason Karch, Cincinnati Children's Hospital Medical Center, USA
Bax and Bak Are Required For Mitochondrial Permeability Transition Pore-Dependent Programmed Cellular Necrosis


Tuesday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, March 20 | 5:00PM - 7:00PM
Building the Organelle: The Import of Protein and Lipids
Room: Van Horne A-B

Speaker 1 of 5
* Mike Ryan, Monash University, Australia

Tuesday, March 20 | 5:00PM - 7:00PM
Building the Organelle: The Import of Protein and Lipids
Room: Van Horne A-B

Speaker 2 of 5
Jodi Nunnari, University of California, Davis, USA
The Behavior of Mitochondria

Tuesday, March 20 | 5:00PM - 7:00PM
Building the Organelle: The Import of Protein and Lipids
Room: Van Horne A-B

Speaker 3 of 5
Hiromi Sesaki, Johns Hopkins University School of Medicine, USA
Mitochondrial Division Prevents Neurodegeneration

Tuesday, March 20 | 5:00PM - 7:00PM
Building the Organelle: The Import of Protein and Lipids
Room: Van Horne A-B

Speaker 4 of 5
Thomas Langer, CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Membrane Dynamics

Tuesday, March 20 | 5:00PM - 7:00PM
Building the Organelle: The Import of Protein and Lipids
Room: Van Horne A-B

Speaker 5 of 5
Nils-Goran Larsson, Karolinska Institutet, Sweden
Short Talk: Posttranscriptional Regulation of mtDNA Expression in Animals

Tuesday, March 20 | 5:00PM - 7:15PM
Atypical Caspase-Dependent Cell Death Mechanisms
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 1 of 6
* Junying Yuan, Harvard Medical School, USA


Tuesday, March 20 | 5:00PM - 7:15PM
Atypical Caspase-Dependent Cell Death Mechanisms
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 2 of 6
Andreas Villunger, Medical University Innsbruck, Austria
The PIDDosome in Cell Death and Cell Cycle Regulation


Tuesday, March 20 | 5:00PM - 7:15PM
Atypical Caspase-Dependent Cell Death Mechanisms
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 3 of 6
David Wallach, Weizmann Institute of Science, Israel
The ‘Apoptotic’ Caspases as Regulators of Inflammation: New Lessons about Caspase-8 Function


Tuesday, March 20 | 5:00PM - 7:15PM
Atypical Caspase-Dependent Cell Death Mechanisms
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 4 of 6
Douglas R. Green, St. Jude Children's Research Hospital, USA
Cutting Both Ways: Why FADD, FLIP, and Caspase-8 are Required for Embryonic Development


Tuesday, March 20 | 5:00PM - 7:15PM
Atypical Caspase-Dependent Cell Death Mechanisms
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 5 of 6
Kenta Moriwaki, University of Massachusetts Medical School, USA
Short Talk: Molecular Mechanism and Pathophysiological Roles of RIP3-Dependent Necrosis


Tuesday, March 20 | 5:00PM - 7:15PM
Atypical Caspase-Dependent Cell Death Mechanisms
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 6 of 6
Liming Sun, Institute of Biochemistry and Cell Biology, SIBS, CAS, China
Short Talk: MLKL Mediates Necrosis Signaling Downstream of RIP3


Tuesday, March 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Tuesday, March 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Mezzanine 2


Wednesday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
Room: Van Horne A-B

Speaker 1 of 7
* Nils-Goran Larsson, Karolinska Institutet, Sweden

Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
Room: Van Horne A-B

Speaker 2 of 7
Paolo Bernardi, University of Padova Medical School, Italy
Pathophysiology of the Mitochondrial Permeability Transition

Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
Room: Van Horne A-B

Speaker 3 of 7
Rosario Rizzuto, University of Padua, Italy
Identification of the Mitochondrial Calcium Uniporter

Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
Room: Van Horne A-B

Speaker 4 of 7
David C. Chan, California Institute of Technology, USA
Analysis of Mitochondrial Dynamics in Mouse Tissues

Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
Room: Van Horne A-B

Speaker 5 of 7
Anu Suomalainen Wartiovaara, University of Helsinki, Finland
Global and Tissue-Specific Consequences of Mitochondrial Dysfunction

Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
Room: Van Horne A-B

Speaker 6 of 7
Pénélope Andreux, Amazentis, Switzerland
Short Talk: A Multi-Level Screen in Mammals and the Worm C. elegans for the Identification of Compounds Improving Mitochondrial Function

Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
Room: Van Horne A-B

Speaker 7 of 7
Vanessa A. Morais, Katholieke Universiteit Leuven & VIB, Belgium
Short Talk: Parkinson’s Disease: PINK1 Regulates Complex I Activity

Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 1 of 7
* Maya Saleh, McGill University, Canada


Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 2 of 7
Andrea Califano, Columbia University, USA
Interrogating Gene Regulatory Networks to Discover Oncogene and Non-Oncogene Addictions in Cancer


Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 3 of 7
Al L. Burlingame, University of California, San Francisco, USA
Cell Death Pathways: Beyond Apoptosis


Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 4 of 7
Paul J. Muchowski, University of California, San Francisco, USA
Using Yeast to Identify Pathways that Modify Neurodegeneration


Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 5 of 7
Cole M. Haynes, University of Massachusetts Medical School, USA
Retrograde Signaling a Mitochondrial Unfolded Protein Response


Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 6 of 7
Burcin Ikiz, Trustees of Columbia University in the City of New York, USA
Short Talk: Unraveling the Molecular Mechanism Underlying ALS-Linked Astrocyte Toxicity to Motor Neurons


Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 7 of 7
Lars Brichta, Rockefeller University, USA
Short Talk: Comparative Translational Profiling of Dopaminergic Neurons in Mouse Models for Parkinson’s Disease


Wednesday, March 21 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Wednesday, March 21 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Wednesday, March 21 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
Room: Van Horne A-B

Speaker 1 of 9
* David C. Chan, California Institute of Technology, USA

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
Room: Van Horne A-B

Speaker 2 of 9
Maria Bohnert, Weizmann Institute of Science, Israel
MINOS, a Novel Mitochondrial Inner Membrane Organizing System

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
Room: Van Horne A-B

Speaker 3 of 9
Uma Sankar, University of Louisville, USA
Regulation of the Mitochondrial Fission GTPase Drp1 by the Sulfhydryl Oxidase GFER

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
Room: Van Horne A-B

Speaker 4 of 9
Axel Niemann, ETH Zürich, Switzerland
GDAP1-Induced Fission Allows Protection during ROS Stress Conditions

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
Room: Van Horne A-B

Speaker 5 of 9
Julio C. B. Ferreira, Institute of Biomedical Sciences, Brazil
Disruption of Mitochondria Fusion Contributes to Heart Failure; A Role for betaIIPKC

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
Room: Van Horne A-B

Speaker 6 of 9
Adam L. Hughes, University of Utah, USA
A Yeast PINK1/Parkin-Like Mitophagy Pathway

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
Room: Van Horne A-B

Speaker 7 of 9
Jonathon L. Burman, University of Washington, USA
Selective Vulnerability of Mitochondria in Parkin Mutant Dopaminergic Neurons

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
Room: Van Horne A-B

Speaker 8 of 9
Lindsay DeVorkin, Deeley Research Centre, Canada
A Drosophila Effector Caspase Mediates Mitochondrial Dynamics and Autophagy

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
Room: Van Horne A-B

Speaker 9 of 9
John J. Lemasters, Medical University of South Carolina, USA
Different Initiators of Mitochondrial Autophagy in Types 1 and 2 Mitophagy

Wednesday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, March 21 | 5:00PM - 7:00PM
The Interface between Mitochondria and the Endoplasmic Retic
ulum

Room: Van Horne A-B

Speaker 1 of 5
* Jodi Nunnari, University of California, Davis, USA

Wednesday, March 21 | 5:00PM - 7:00PM
The Interface between Mitochondria and the Endoplasmic Retic
ulum

Room: Van Horne A-B

Speaker 2 of 5
Gia K. Voeltz, University of Colorado Boulder, USA
ER Tubules Mark Sites of Mitochondrial Division

Wednesday, March 21 | 5:00PM - 7:00PM
The Interface between Mitochondria and the Endoplasmic Retic
ulum

Room: Van Horne A-B

Speaker 3 of 5
György Hajnóczky, Thomas Jefferson University, USA
Mechanisms of ER-Mitochondrial Local Communication

Wednesday, March 21 | 5:00PM - 7:00PM
The Interface between Mitochondria and the Endoplasmic Retic
ulum

Room: Van Horne A-B

Speaker 4 of 5
Francesco Cecconi, University of Rome Tor Vergata, Italy
ER-Mitochondria Cross-Talk and the Clash between Autophagy and Cell Cycle Progression

Wednesday, March 21 | 5:00PM - 7:00PM
The Interface between Mitochondria and the Endoplasmic Retic
ulum

Room: Van Horne A-B

Speaker 5 of 5
Brendan J. Battersby, University of Helsinki, Finland
Short Talk: Gimap3 Modifying mtDNA Segregation through Autophagy

Wednesday, March 21 | 5:00PM - 7:15PM
Bcl-2 Protein Family
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 1 of 6
* Rajiv R. Ratan, Burke-Cornell Medical Research Institute, USA


Wednesday, March 21 | 5:00PM - 7:15PM
Bcl-2 Protein Family
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 2 of 6
Atan J. Gross, Weizmann Institute of Science, Israel
A Novel Mitochondrial Pathway that Regulates Cell Fate and Function


Wednesday, March 21 | 5:00PM - 7:15PM
Bcl-2 Protein Family
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 3 of 6
Ruth M. Kluck, Walter and Eliza Hall Institute of Medical Research, Australia
How Bak and Bax Permeabilize Mitochondria during Cell Death


Wednesday, March 21 | 5:00PM - 7:15PM
Bcl-2 Protein Family
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 4 of 6
Maya Saleh, McGill University, Canada
The Pro-Apoptotic Protein BID is Required for NOD-Mediated Inflammation and Innate Immunity


Wednesday, March 21 | 5:00PM - 7:15PM
Bcl-2 Protein Family
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 5 of 6
Tomomi Kuwana, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Bax Forms Two Types of Pores in the Mitochondrial Outer Membrane: Slow- and Fast-Release


Wednesday, March 21 | 5:00PM - 7:15PM
Bcl-2 Protein Family
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 6 of 6
Levi J. Beverly, University of Louisville, USA
Short Talk: Combining Mouse Models, Biochemistry and Drug Screens to Understand the Role BCL2-Proteins in Human Cancer Initiation and Therapeutic Interventions


Wednesday, March 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Wednesday, March 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Mezzanine 2


Thursday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
Room: Van Horne A-B

Speaker 1 of 7
* Thomas Langer, CECAD Research Center, Germany

Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
Room: Van Horne A-B

Speaker 2 of 7
Janet M. Shaw, University of Utah, USA
Identification of the Minimal Mitochondrial Fission Machinery in Yeast and Humans

Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
Room: Van Horne A-B

Speaker 3 of 7
Mike Ryan, Monash University, Australia
Novel Mediators of Mitochondrial Morphology

Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
Room: Van Horne A-B

Speaker 4 of 7
Robert A. Screaton, Sunnybrook Research Institute, Canada
Short Talk: Genome-Wide RNAi Screening Identifies Novel Regulators of Mitochondrial Morphology

Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
Room: Van Horne A-B

Speaker 5 of 7
Antonio Zorzano, Institute for Research in Biomedicine, Spain
Mfn2 Links Mitochondrial and ER Function with Insulin Signaling

Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
Room: Van Horne A-B

Speaker 6 of 7
Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA
Cell-Cycle Regulation of Mitochondrial Fusion and Fission

Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
Room: Van Horne A-B

Speaker 7 of 7
Xiaodong Wang, BeiGene, China
Mitochondrial Phosphatase PGAM5 Participates in Necrosis Execution

Thursday, March 22 | 8:00AM - 11:00AM
Non-Cell Autonomous Mechanisms of Death
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 1 of 6
* Kim McCall, Boston University, USA


Thursday, March 22 | 8:00AM - 11:00AM
Non-Cell Autonomous Mechanisms of Death
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 2 of 6
Serge Przedborski, Columbia University, USA
Astrocytes and Motor Neuron Degeneration


Thursday, March 22 | 8:00AM - 11:00AM
Non-Cell Autonomous Mechanisms of Death
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 3 of 6
Gwenn A. Garden, University of Washington, USA
Microglia Mediated Neurotoxicity is Downstream of Reactive Oxygen Species, p53 and microRNAs


Thursday, March 22 | 8:00AM - 11:00AM
Non-Cell Autonomous Mechanisms of Death
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 4 of 6
Christian Münch, Harvard Medical School, The Harper Lab, USA
Prion-Like Propagation of Mutant Superoxide Dismutase-1 Misfolding


Thursday, March 22 | 8:00AM - 11:00AM
Non-Cell Autonomous Mechanisms of Death
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 5 of 6
Beata Jablonska, Children's National Medical Center, USA
FoxO-Dependent Regulation of p27Kip1 Controls Oligodendrocyte Differentiation after Perinatal Hypoxia


Thursday, March 22 | 8:00AM - 11:00AM
Non-Cell Autonomous Mechanisms of Death
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 6 of 6
Takeshi Watanabe, University of Tokyo, Japan
Short Talk: Regulation of NR4A Nuclear Receptors by the ASK-p38 MAP Kinase Pathway-Dependent Phosphorylation


Thursday, March 22 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Thursday, March 22 | 11:30AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Thursday, March 22 | 11:30AM - 11:30AM
On Own for Lunch and Recreation


Thursday, March 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Thursday, March 22 | 2:30PM - 3:30PM
Workshop 2: Mitochondria on the Move
Room: Van Horne A-B

Speaker 1 of 5
* György Hajnóczky, Thomas Jefferson University, USA

Thursday, March 22 | 2:30PM - 3:30PM
Workshop 2: Mitochondria on the Move
Room: Van Horne A-B

Speaker 2 of 5
Konrad E. Zinsmaier, University of Arizona, USA
Miro Controls Mitochondrial Transport, Structure, and Health in Axons through its GTPase or EF-Hand Domains

Thursday, March 22 | 2:30PM - 3:30PM
Workshop 2: Mitochondria on the Move
Room: Van Horne A-B

Speaker 3 of 5
Richard A. Kahn, Emory University School of Medicine, USA
Roles of the ARL2 GTPase at Mitochondria

Thursday, March 22 | 2:30PM - 3:30PM
Workshop 2: Mitochondria on the Move
Room: Van Horne A-B

Speaker 4 of 5
Ghazaleh Ashrafi, Harvard University, USA
Damage to Neuronal Mitochondria Arrests their Motility Prior to Mitophagy

Thursday, March 22 | 2:30PM - 3:30PM
Workshop 2: Mitochondria on the Move
Room: Van Horne A-B

Speaker 5 of 5
Romain Cartoni, Children's Hospital Boston, Harvard Medical School, USA
Co-Deletion of PTEN and SOCS3 Enhance Mitochondrial Transport after Axonal Injury

Thursday, March 22 | 3:30PM - 4:30PM
Workshop 3: Mitochondria and Endoplasmic Reticulum: Structur
al and Functional Interplay
Room: Van Horne A-B

Speaker 1 of 5
* Gia K. Voeltz, University of Colorado Boulder, USA

Thursday, March 22 | 3:30PM - 4:30PM
Workshop 3: Mitochondria and Endoplasmic Reticulum: Structur
al and Functional Interplay
Room: Van Horne A-B

Speaker 2 of 5
Laura L. Lackner, Northwestern University, USA
An ER-Associated Mitochondria-Cortex Tether Functions in the Distribution and Inheritance of Mitochondria

Thursday, March 22 | 3:30PM - 4:30PM
Workshop 3: Mitochondria and Endoplasmic Reticulum: Structur
al and Functional Interplay
Room: Van Horne A-B

Speaker 3 of 5
Valentina Debattisti, Thomas Jefferson University, USA
Marf, the Single Mitofusin of D. Melanogaster, is Selectively Complemented by Mitofusin 2

Thursday, March 22 | 3:30PM - 4:30PM
Workshop 3: Mitochondria and Endoplasmic Reticulum: Structur
al and Functional Interplay
Room: Van Horne A-B

Speaker 4 of 5
Heather M. Lamb, Johns Hopkins Bloomberg School of Public Health, USA
Coexpression of Bax and Bcl-xL in the Secretory Pathway Alters ER Structure

Thursday, March 22 | 3:30PM - 4:30PM
Workshop 3: Mitochondria and Endoplasmic Reticulum: Structur
al and Functional Interplay
Room: Van Horne A-B

Speaker 5 of 5
Clement A. Gautier, Institut du Cerveau et de la moelle Epiniere, France
Novel Role for Parkin in the Regulation of the Physical and Functional Interactions between Mitochondria and the Endoplasmic Reticulum

Thursday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, March 22 | 5:00PM - 7:00PM
The Interface between Mitochondria, Metabolism and Cell Deat
h

Room: Van Horne A-B

Speaker 1 of 5
* Paolo Bernardi, University of Padova Medical School, Italy

Thursday, March 22 | 5:00PM - 7:00PM
The Interface between Mitochondria, Metabolism and Cell Deat
h

Room: Van Horne A-B

Speaker 2 of 5
Vamsi K. Mootha, Massachusetts General Hospital, USA
Discovery of the Mitochondrial Calcium Uniporter via Genomics

Thursday, March 22 | 5:00PM - 7:00PM
The Interface between Mitochondria, Metabolism and Cell Deat
h

Room: Van Horne A-B

Speaker 3 of 5
Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Mitochondrial Control of Autophagy

Thursday, March 22 | 5:00PM - 7:00PM
The Interface between Mitochondria, Metabolism and Cell Deat
h

Room: Van Horne A-B

Speaker 4 of 5
Nika N. Danial, Dana-Farber Cancer Institute, USA
Programming the Mitochondrial Carbon Substrate Utilization: A Role for BAD

Thursday, March 22 | 5:00PM - 7:00PM
The Interface between Mitochondria, Metabolism and Cell Deat
h

Room: Van Horne A-B

Speaker 5 of 5
Christian Frezza, Hutchison/MRC Research Centre, UK
Short Talk: Haem Oxygenase is Synthetically Lethal with the Tumor Suppressor Fumarate Hydratase

Thursday, March 22 | 5:00PM - 7:15PM
Cell Death Therapeutics
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 1 of 6
* Douglas R. Green, St. Jude Children's Research Hospital, USA


Thursday, March 22 | 5:00PM - 7:15PM
Cell Death Therapeutics
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 2 of 6
Carol M. Troy, Columbia University Medical Center, USA
Intranasal Cell Permeant Caspase Inhibitors – Therapeutics for Cerebral Ischemia and other Neurologic Disorders


Thursday, March 22 | 5:00PM - 7:15PM
Cell Death Therapeutics
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 3 of 6
Loren D. Walensky, Dana-Farber Cancer Institute, USA
Mining the Repertoire of BH3 Interaction Sites for Next Generation Pro-Apoptotic Therapies


Thursday, March 22 | 5:00PM - 7:15PM
Cell Death Therapeutics
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 4 of 6
Rajiv R. Ratan, Burke-Cornell Medical Research Institute, USA
Epigenetic Modifiers Prevent Neurodegeneration: HDACs and Beyond


Thursday, March 22 | 5:00PM - 7:15PM
Cell Death Therapeutics
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 5 of 6
Liane Wagner, University Medical Center Ulm, Germany
Short Talk: Smac Mimetic Sensitizes Glioblastoma Cells to Temozolomide-Induced Apoptosis via Ripoptosome Formation


Thursday, March 22 | 5:00PM - 7:15PM
Cell Death Therapeutics
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 6 of 6
Johannes Noack, DKFZ - German Cancer Research Center, Germany
Short Talk: Combination of a Sphingosine Kinase Inhibitor and Temozolomide Results in a Strong Synergistic Cytotoxic Effect which Displays Features of Various Cell Death Pathways


Thursday, March 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Thursday, March 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Mezzanine 2


Friday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 1 of 7
* Heidi M. McBride, McGill University, Canada

Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 2 of 7
Mondira Kundu, St. Jude Children's Hospital, USA
ULK1: Linking Mitophagy with the Cellular Response to Stress

Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 3 of 7
Koji Okamoto, Osaka University, Japan
Molecular Mechanism of Mitochondria-specific Autophagy in Yeast

Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 4 of 7
Paul A. Ney, New York Blood Center, USA
A Single Amino in NIX is Essential for Mitochondrial Clearance in Reticulocytes

Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 5 of 7
Richard J. Youle, NINDS, National Institutes of Health, USA
Damage Control - How the Pink1/Parkin pathway can regulate removal of impaired mitochondria by autophagy

Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 6 of 7
Rudolf J. Wiesner, University of Cologne, Germany
Short Talk: Not the Assembly, the Stability of Respiratory Chain Complexes is Impaired by Nonsense Mutations in mtDNA Encoded Respiratory Chain Subunits

Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 7 of 7
Matthew J. LaVoie, Brigham and Women's Hospital and Harvard Medical School, USA
Short Talk: Parkin Ubiquitinates Bax to Regulate the Apoptotic Response of Mitochondria

Friday, March 23 | 9:00AM - 9:20AM
Coffee Break
Room: Van Horne Foyer


Friday, March 23 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 1 of 8
* John J. Lemasters, Medical University of South Carolina, USA


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 2 of 8
Su-Jeong Kim, University of Southern California, USA
Nuclear Translocation of DJ-1 during Oxidative Stress-Induced Neuronal Cell Death


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 3 of 8
Devrim Gozuacik, Sabanci University, Turkey
MicroRNA Control of Autophagy


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 4 of 8
Charles A. O'Brien, University of Arkansas for Medical Sciences, USA
Osteocyte Autophagy Declines with Age in Mice and Suppression
of Osteocyte Autophagy Decreases Bone Mass and Mimics Skeletal Aging


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 5 of 8
Jennifer Martinez, NIEHS, National Institutes of Health, USA
LC3-Associated Phagocytosis is Required for Efficient Clearance of Dead Cells


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 6 of 8
Babul Moni Ram, National Cancer Institute, USA
Calcineurin Inhibitor Cyclosporine A Induces Endoplasmic Reticulum Stress Mediated Non Apoptotic Cell Death Response


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 7 of 8
Melanie J. Scott, University of Pittsburgh, USA
Caspase-1-Dependent Mitophagy Regulates Liver Damage and Cell Death after Hemorrhagic Shock in Mice


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 8 of 8
Melissa Vos, University of Lübeck, Germany
Vitamin K2 is a Mitochondrial Electron Carrier that Rescues Pink1 Deficiency


Friday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Friday, March 23 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Disease
Room: Van Horne A-B

Speaker 1 of 4
* Anu Suomalainen Wartiovaara, University of Helsinki, Finland

Friday, March 23 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Disease
Room: Van Horne A-B

Speaker 2 of 4
Gerald W. Dorn, II, Washington University School of Medicine, USA
The Varied Roles of Mitofusins in the Heart

Friday, March 23 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Disease
Room: Van Horne A-B

Speaker 3 of 4
Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy: An Immunity Paradigm with Mitochondria as a Centerpiece

Friday, March 23 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Disease
Room: Van Horne A-B

Speaker 4 of 4
Michelle L. Boland, Medimmune, USA
Short Talk: Bnip3 is Required to Prevent Hepatic Steatosis and Deficiencies in Gluconeogensis through Effects at the Mitochondria

Friday, March 23 | 5:00PM - 7:00PM
Use and Interpretation of Assays for Monitoring Mitophagy
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 1 of 3
* Paul A. Ney, New York Blood Center, USA


Friday, March 23 | 5:00PM - 7:00PM
Use and Interpretation of Assays for Monitoring Mitophagy
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 2 of 3
Orian S. Shirihai, University of California, Los Angeles, USA
Live Imaging of Mitophagy in Mammalian Cells


Friday, March 23 | 5:00PM - 7:00PM
Use and Interpretation of Assays for Monitoring Mitophagy
This session is from Cell Death Pathways
Room: Van Horne C

Speaker 3 of 3
Hagai Abeliovich, Hebrew University of Jerusalem, Israel
Mitophagy as a Quality Control Mechanism in Saccharomyces cerevisiae


Friday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Friday, March 23 | 8:00PM - 11:00PM
Entertainment
Room: Mezzanine 2


Friday, March 23 | 8:00PM - 11:00PM
Cash Bar
Room: Mezzanine 2


Saturday, March 24 | 10:25AM - 10:25AM
Departure


*Session Chair.