Web Desc
Cell Death Pathways: Beyond Apoptosis
joint with Mitochondrial Dynamics and Function
Organizer(s): Serge Przedborski and Richard J. Youle
Date: March 19 - 24, 2012
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by Abbott Laboratories, Astellas Pharma Inc. and Genentech, Inc.
Summary of Meeting:
Mounting evidence indicates that cell death in diseases results from complex interactions between molecular mechanisms taking place within the degenerating cells (cell-autonomous) and outside the degenerating cells (non-cell autonomous). At the cross roads of these diverse signaling pathways are found the mitochondria which, through proper mitochondrial dynamics and regulated mitochondrial elimination by autophagy (i.e., mitophagy), play a crucial role in maintaining the well-being of the cells. This meeting will focus on the general mechanisms of cell death including the Bcl-2 family and caspase proteases, the role of mitochondrial dynamics and mitophagy, the usefulness of bioinformatics to unravel death-pathways, the contribution of non-cell autonomous mechanisms to cell death and the therapeutic strategies to protect against cell death. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Mitochondrial Dynamics and Function, which will share a keynote address and two plenary sessions with this meeting.
Scholarship Deadline: November 17 2011
Discounted Abstract Deadline: November 17 2011
Abstract Deadline: December 21 2011
Discounted Registration Deadline: January 19 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Abbott LaboratoriesAstellas Pharma Inc.Genentech, Inc.
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS077708-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, March 19 | 3:00PM - 7:30PM
Registration
Room: Van Horne Foyer


Monday, March 19 | 6:15PM - 7:15PM
Refreshments
Room: Van Horne Foyer


Monday, March 19 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne A-B

Speaker 1 of 4
* Luca Scorrano, University of Padova, Italy

Monday, March 19 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne A-B

Speaker 2 of 4
Heidi M. McBride, McGill University, Canada
Mitochondrial Dynamics and Quality Control

Monday, March 19 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne A-B

Speaker 3 of 4
Junying Yuan, Harvard Medical School, USA
Programmed Cell Death: From Apoptosis to Necroptosis

Monday, March 19 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne A-B

Speaker 4 of 4
* Serge Przedborski, Columbia University, USA

Tuesday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 1 of 7
* Richard J. Youle, NINDS, National Institutes of Health, USA

Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 2 of 7
Kim McCall, Boston University, USA
Mitochondrial Dynamics and Cell Death in Drosophila Oogenesis

Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 3 of 7
Luca Scorrano, University of Padova, Italy
Integrating Mitochondrial Morphology and Ultrastructure in the Control of Apoptosis: Lessons from Cellular and Mouse Models

Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 4 of 7
Seamus J. Martin, Trinity College Dublin, Ireland
Mitochondrial Quality Control and the Bcl-2 Family

Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 5 of 7
Joseph T. Opferman, St. Jude Children's Research Hospital, USA
Anti-Apoptotic MCL-1 Localizes to the Mitochondrial Matrix and Regulates Mitochondrial Function

Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 6 of 7
Michelangelo Campanella, RVC and UCL Consortium for Mitochondrial Research, UK
Short Talk: The F1FO-ATPsynthase Inhibitor IF1 Controls Apoptosis by Regulating Mitochondrial Dynamics

Tuesday, March 20 | 8:00AM - 11:15AM
Mitochondrial Dynamics in Cell Death (Joint)
Room: Van Horne A-B

Speaker 7 of 7
Nuno Raimundo, University Medical Center Goettingen, Germany
Short Talk: Mitochondrial Stress Triggers E2F1 Apoptotic Signaling to Cause Deafness – Insights into Tissue-Specific Mechanisms

Tuesday, March 20 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Tuesday, March 20 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Tuesday, March 20 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
Room: Van Horne C

Speaker 1 of 7
* Carol M. Troy, Columbia University Medical Center, USA

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
Room: Van Horne C

Speaker 2 of 7
Patrick A. Lewis, University of Reading, UK
The ROC Domain of DAPK1 as a Controller of DAPK1 Function and Cell Death

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
Room: Van Horne C

Speaker 3 of 7
Meera Nanjundan, University of South Florida, USA
Role of SnoN/SkiL in Modulating Cell Death Pathways in the Pathogenesis of Ovarian Cancer

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
Room: Van Horne C

Speaker 4 of 7
Sho Morioka, North Carolina State University, USA
TAK1 Regulates Mitochondrial Integrity, Which Is Important for Preventing TNF-Induced Endothelial Cell Death and Vascular Development

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
Room: Van Horne C

Speaker 5 of 7
Yuxing Zhao, St. Vincent's Institute, Australia
Apoptotic and Non-Apoptotic Pathways Lead to Pancreatic beta Cell Destruction in Type 1 Diabetes

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
Room: Van Horne C

Speaker 6 of 7
Susan E. Brockerhoff, University of Washington, USA
Mechanisms of Photoreceptor Degeneration

Tuesday, March 20 | 2:30PM - 4:30PM
Workshop 1: Non-Apoptotic Death Pathways: Mechanisms and Con
sequences
Room: Van Horne C

Speaker 7 of 7
Jason Karch, Cincinnati Children's Hospital Medical Center, USA
Bax and Bak Are Required For Mitochondrial Permeability Transition Pore-Dependent Programmed Cellular Necrosis

Tuesday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, March 20 | 5:00PM - 7:15PM
Atypical Caspase-Dependent Cell Death Mechanisms
Room: Van Horne C

Speaker 1 of 6
* Junying Yuan, Harvard Medical School, USA

Tuesday, March 20 | 5:00PM - 7:15PM
Atypical Caspase-Dependent Cell Death Mechanisms
Room: Van Horne C

Speaker 2 of 6
Andreas Villunger, Medical University Innsbruck, Austria
The PIDDosome in Cell Death and Cell Cycle Regulation

Tuesday, March 20 | 5:00PM - 7:15PM
Atypical Caspase-Dependent Cell Death Mechanisms
Room: Van Horne C

Speaker 3 of 6
David Wallach, Weizmann Institute of Science, Israel
The ‘Apoptotic’ Caspases as Regulators of Inflammation: New Lessons about Caspase-8 Function

Tuesday, March 20 | 5:00PM - 7:15PM
Atypical Caspase-Dependent Cell Death Mechanisms
Room: Van Horne C

Speaker 4 of 6
Douglas R. Green, St. Jude Children's Research Hospital, USA
Cutting Both Ways: Why FADD, FLIP, and Caspase-8 are Required for Embryonic Development

Tuesday, March 20 | 5:00PM - 7:15PM
Atypical Caspase-Dependent Cell Death Mechanisms
Room: Van Horne C

Speaker 5 of 6
Kenta Moriwaki, University of Massachusetts Medical School, USA
Short Talk: Molecular Mechanism and Pathophysiological Roles of RIP3-Dependent Necrosis

Tuesday, March 20 | 5:00PM - 7:15PM
Atypical Caspase-Dependent Cell Death Mechanisms
Room: Van Horne C

Speaker 6 of 6
Liming Sun, Institute of Biochemistry and Cell Biology, SIBS, CAS, China
Short Talk: MLKL Mediates Necrosis Signaling Downstream of RIP3

Tuesday, March 20 | 5:00PM - 7:00PM
Building the Organelle: The Import of Protein and Lipids
This session is from Mitochondria
Room: Van Horne A-B

Speaker 1 of 5
* Mike Ryan, Monash University, Australia


Tuesday, March 20 | 5:00PM - 7:00PM
Building the Organelle: The Import of Protein and Lipids
This session is from Mitochondria
Room: Van Horne A-B

Speaker 2 of 5
Jodi Nunnari, University of California, Davis, USA
The Behavior of Mitochondria


Tuesday, March 20 | 5:00PM - 7:00PM
Building the Organelle: The Import of Protein and Lipids
This session is from Mitochondria
Room: Van Horne A-B

Speaker 3 of 5
Hiromi Sesaki, Johns Hopkins University School of Medicine, USA
Mitochondrial Division Prevents Neurodegeneration


Tuesday, March 20 | 5:00PM - 7:00PM
Building the Organelle: The Import of Protein and Lipids
This session is from Mitochondria
Room: Van Horne A-B

Speaker 4 of 5
Thomas Langer, CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Membrane Dynamics


Tuesday, March 20 | 5:00PM - 7:00PM
Building the Organelle: The Import of Protein and Lipids
This session is from Mitochondria
Room: Van Horne A-B

Speaker 5 of 5
Nils-Goran Larsson, Karolinska Institutet, Sweden
Short Talk: Posttranscriptional Regulation of mtDNA Expression in Animals


Tuesday, March 20 | 7:15PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Tuesday, March 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Mezzanine 2


Wednesday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
Room: Van Horne C

Speaker 1 of 7
* Maya Saleh, McGill University, Canada

Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
Room: Van Horne C

Speaker 2 of 7
Andrea Califano, Columbia University, USA
Interrogating Gene Regulatory Networks to Discover Oncogene and Non-Oncogene Addictions in Cancer

Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
Room: Van Horne C

Speaker 3 of 7
Al L. Burlingame, University of California, San Francisco, USA
Cell Death Pathways: Beyond Apoptosis

Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
Room: Van Horne C

Speaker 4 of 7
Paul J. Muchowski, University of California, San Francisco, USA
Using Yeast to Identify Pathways that Modify Neurodegeneration

Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
Room: Van Horne C

Speaker 5 of 7
Cole M. Haynes, University of Massachusetts Medical School, USA
Retrograde Signaling a Mitochondrial Unfolded Protein Response

Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
Room: Van Horne C

Speaker 6 of 7
Burcin Ikiz, Trustees of Columbia University in the City of New York, USA
Short Talk: Unraveling the Molecular Mechanism Underlying ALS-Linked Astrocyte Toxicity to Motor Neurons

Wednesday, March 21 | 8:00AM - 11:15AM
Bioinformatics at the Service of the Death-omes
Room: Van Horne C

Speaker 7 of 7
Lars Brichta, Rockefeller University, USA
Short Talk: Comparative Translational Profiling of Dopaminergic Neurons in Mouse Models for Parkinson’s Disease

Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
This session is from Mitochondria
Room: Van Horne A-B

Speaker 1 of 7
* Nils-Goran Larsson, Karolinska Institutet, Sweden


Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
This session is from Mitochondria
Room: Van Horne A-B

Speaker 2 of 7
Paolo Bernardi, University of Padova Medical School, Italy
Pathophysiology of the Mitochondrial Permeability Transition


Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
This session is from Mitochondria
Room: Van Horne A-B

Speaker 3 of 7
Rosario Rizzuto, University of Padua, Italy
Identification of the Mitochondrial Calcium Uniporter


Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
This session is from Mitochondria
Room: Van Horne A-B

Speaker 4 of 7
David C. Chan, California Institute of Technology, USA
Analysis of Mitochondrial Dynamics in Mouse Tissues


Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
This session is from Mitochondria
Room: Van Horne A-B

Speaker 5 of 7
Anu Suomalainen Wartiovaara, University of Helsinki, Finland
Global and Tissue-Specific Consequences of Mitochondrial Dysfunction


Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
This session is from Mitochondria
Room: Van Horne A-B

Speaker 6 of 7
Pénélope Andreux, Amazentis, Switzerland
Short Talk: A Multi-Level Screen in Mammals and the Worm C. elegans for the Identification of Compounds Improving Mitochondrial Function


Wednesday, March 21 | 8:00AM - 11:15AM
Making the Organelle to Work: From Genetics to (Dys)function
This session is from Mitochondria
Room: Van Horne A-B

Speaker 7 of 7
Vanessa A. Morais, Katholieke Universiteit Leuven & VIB, Belgium
Short Talk: Parkinson’s Disease: PINK1 Regulates Complex I Activity


Wednesday, March 21 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Wednesday, March 21 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Wednesday, March 21 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
This session is from Mitochondria
Room: Van Horne A-B

Speaker 1 of 9
* David C. Chan, California Institute of Technology, USA


Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
This session is from Mitochondria
Room: Van Horne A-B

Speaker 2 of 9
Maria Bohnert, Weizmann Institute of Science, Israel
MINOS, a Novel Mitochondrial Inner Membrane Organizing System


Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
This session is from Mitochondria
Room: Van Horne A-B

Speaker 3 of 9
Uma Sankar, University of Louisville, USA
Regulation of the Mitochondrial Fission GTPase Drp1 by the Sulfhydryl Oxidase GFER


Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
This session is from Mitochondria
Room: Van Horne A-B

Speaker 4 of 9
Axel Niemann, ETH Zürich, Switzerland
GDAP1-Induced Fission Allows Protection during ROS Stress Conditions


Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
This session is from Mitochondria
Room: Van Horne A-B

Speaker 5 of 9
Julio C. B. Ferreira, Institute of Biomedical Sciences, Brazil
Disruption of Mitochondria Fusion Contributes to Heart Failure; A Role for betaIIPKC


Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
This session is from Mitochondria
Room: Van Horne A-B

Speaker 6 of 9
Adam L. Hughes, University of Utah, USA
A Yeast PINK1/Parkin-Like Mitophagy Pathway


Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
This session is from Mitochondria
Room: Van Horne A-B

Speaker 7 of 9
Jonathon L. Burman, University of Washington, USA
Selective Vulnerability of Mitochondria in Parkin Mutant Dopaminergic Neurons


Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
This session is from Mitochondria
Room: Van Horne A-B

Speaker 8 of 9
Lindsay DeVorkin, Deeley Research Centre, Canada
A Drosophila Effector Caspase Mediates Mitochondrial Dynamics and Autophagy


Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Extending Mitochondrial Fusion and Fission: Mech
anisms and Consequences
This session is from Mitochondria
Room: Van Horne A-B

Speaker 9 of 9
John J. Lemasters, Medical University of South Carolina, USA
Different Initiators of Mitochondrial Autophagy in Types 1 and 2 Mitophagy


Wednesday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, March 21 | 5:00PM - 7:15PM
Bcl-2 Protein Family
Room: Van Horne C

Speaker 1 of 6
* Rajiv R. Ratan, Burke-Cornell Medical Research Institute, USA

Wednesday, March 21 | 5:00PM - 7:15PM
Bcl-2 Protein Family
Room: Van Horne C

Speaker 2 of 6
Atan J. Gross, Weizmann Institute of Science, Israel
A Novel Mitochondrial Pathway that Regulates Cell Fate and Function

Wednesday, March 21 | 5:00PM - 7:15PM
Bcl-2 Protein Family
Room: Van Horne C

Speaker 3 of 6
Ruth M. Kluck, Walter and Eliza Hall Institute of Medical Research, Australia
How Bak and Bax Permeabilize Mitochondria during Cell Death

Wednesday, March 21 | 5:00PM - 7:15PM
Bcl-2 Protein Family
Room: Van Horne C

Speaker 4 of 6
Maya Saleh, McGill University, Canada
The Pro-Apoptotic Protein BID is Required for NOD-Mediated Inflammation and Innate Immunity

Wednesday, March 21 | 5:00PM - 7:15PM
Bcl-2 Protein Family
Room: Van Horne C

Speaker 5 of 6
Tomomi Kuwana, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Bax Forms Two Types of Pores in the Mitochondrial Outer Membrane: Slow- and Fast-Release

Wednesday, March 21 | 5:00PM - 7:15PM
Bcl-2 Protein Family
Room: Van Horne C

Speaker 6 of 6
Levi J. Beverly, University of Louisville, USA
Short Talk: Combining Mouse Models, Biochemistry and Drug Screens to Understand the Role BCL2-Proteins in Human Cancer Initiation and Therapeutic Interventions

Wednesday, March 21 | 5:00PM - 7:00PM
The Interface between Mitochondria and the Endoplasmic Retic
ulum
This session is from Mitochondria

Room: Van Horne A-B

Speaker 1 of 5
* Jodi Nunnari, University of California, Davis, USA


Wednesday, March 21 | 5:00PM - 7:00PM
The Interface between Mitochondria and the Endoplasmic Retic
ulum
This session is from Mitochondria

Room: Van Horne A-B

Speaker 2 of 5
Gia K. Voeltz, University of Colorado Boulder, USA
ER Tubules Mark Sites of Mitochondrial Division


Wednesday, March 21 | 5:00PM - 7:00PM
The Interface between Mitochondria and the Endoplasmic Retic
ulum
This session is from Mitochondria

Room: Van Horne A-B

Speaker 3 of 5
György Hajnóczky, Thomas Jefferson University, USA
Mechanisms of ER-Mitochondrial Local Communication


Wednesday, March 21 | 5:00PM - 7:00PM
The Interface between Mitochondria and the Endoplasmic Retic
ulum
This session is from Mitochondria

Room: Van Horne A-B

Speaker 4 of 5
Francesco Cecconi, University of Rome Tor Vergata, Italy
ER-Mitochondria Cross-Talk and the Clash between Autophagy and Cell Cycle Progression


Wednesday, March 21 | 5:00PM - 7:00PM
The Interface between Mitochondria and the Endoplasmic Retic
ulum
This session is from Mitochondria

Room: Van Horne A-B

Speaker 5 of 5
Brendan J. Battersby, University of Helsinki, Finland
Short Talk: Gimap3 Modifying mtDNA Segregation through Autophagy


Wednesday, March 21 | 7:15PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Wednesday, March 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Mezzanine 2


Thursday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Thursday, March 22 | 8:00AM - 11:00AM
Non-Cell Autonomous Mechanisms of Death
Room: Van Horne C

Speaker 1 of 6
* Kim McCall, Boston University, USA

Thursday, March 22 | 8:00AM - 11:00AM
Non-Cell Autonomous Mechanisms of Death
Room: Van Horne C

Speaker 2 of 6
Serge Przedborski, Columbia University, USA
Astrocytes and Motor Neuron Degeneration

Thursday, March 22 | 8:00AM - 11:00AM
Non-Cell Autonomous Mechanisms of Death
Room: Van Horne C

Speaker 3 of 6
Gwenn A. Garden, University of Washington, USA
Microglia Mediated Neurotoxicity is Downstream of Reactive Oxygen Species, p53 and microRNAs

Thursday, March 22 | 8:00AM - 11:00AM
Non-Cell Autonomous Mechanisms of Death
Room: Van Horne C

Speaker 4 of 6
Christian Münch, Harvard Medical School, The Harper Lab, USA
Prion-Like Propagation of Mutant Superoxide Dismutase-1 Misfolding

Thursday, March 22 | 8:00AM - 11:00AM
Non-Cell Autonomous Mechanisms of Death
Room: Van Horne C

Speaker 5 of 6
Beata Jablonska, Children's National Medical Center, USA
FoxO-Dependent Regulation of p27Kip1 Controls Oligodendrocyte Differentiation after Perinatal Hypoxia

Thursday, March 22 | 8:00AM - 11:00AM
Non-Cell Autonomous Mechanisms of Death
Room: Van Horne C

Speaker 6 of 6
Takeshi Watanabe, University of Tokyo, Japan
Short Talk: Regulation of NR4A Nuclear Receptors by the ASK-p38 MAP Kinase Pathway-Dependent Phosphorylation

Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
This session is from Mitochondria
Room: Van Horne A-B

Speaker 1 of 7
* Thomas Langer, CECAD Research Center, Germany


Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
This session is from Mitochondria
Room: Van Horne A-B

Speaker 2 of 7
Janet M. Shaw, University of Utah, USA
Identification of the Minimal Mitochondrial Fission Machinery in Yeast and Humans


Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
This session is from Mitochondria
Room: Van Horne A-B

Speaker 3 of 7
Mike Ryan, Monash University, Australia
Novel Mediators of Mitochondrial Morphology


Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
This session is from Mitochondria
Room: Van Horne A-B

Speaker 4 of 7
Robert A. Screaton, Sunnybrook Research Institute, Canada
Short Talk: Genome-Wide RNAi Screening Identifies Novel Regulators of Mitochondrial Morphology


Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
This session is from Mitochondria
Room: Van Horne A-B

Speaker 5 of 7
Antonio Zorzano, Institute for Research in Biomedicine, Spain
Mfn2 Links Mitochondrial and ER Function with Insulin Signaling


Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
This session is from Mitochondria
Room: Van Horne A-B

Speaker 6 of 7
Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA
Cell-Cycle Regulation of Mitochondrial Fusion and Fission


Thursday, March 22 | 8:00AM - 11:30AM
Mitochondrial Fusion and Fission: Mechanisms and Regulation
This session is from Mitochondria
Room: Van Horne A-B

Speaker 7 of 7
Xiaodong Wang, BeiGene, China
Mitochondrial Phosphatase PGAM5 Participates in Necrosis Execution


Thursday, March 22 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Thursday, March 22 | 11:00AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Thursday, March 22 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, March 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Thursday, March 22 | 2:30PM - 3:30PM
Workshop 2: Mitochondria on the Move
This session is from Mitochondria
Room: Van Horne A-B

Speaker 1 of 5
* György Hajnóczky, Thomas Jefferson University, USA


Thursday, March 22 | 2:30PM - 3:30PM
Workshop 2: Mitochondria on the Move
This session is from Mitochondria
Room: Van Horne A-B

Speaker 2 of 5
Konrad E. Zinsmaier, University of Arizona, USA
Miro Controls Mitochondrial Transport, Structure, and Health in Axons through its GTPase or EF-Hand Domains


Thursday, March 22 | 2:30PM - 3:30PM
Workshop 2: Mitochondria on the Move
This session is from Mitochondria
Room: Van Horne A-B

Speaker 3 of 5
Richard A. Kahn, Emory University School of Medicine, USA
Roles of the ARL2 GTPase at Mitochondria


Thursday, March 22 | 2:30PM - 3:30PM
Workshop 2: Mitochondria on the Move
This session is from Mitochondria
Room: Van Horne A-B

Speaker 4 of 5
Ghazaleh Ashrafi, Harvard University, USA
Damage to Neuronal Mitochondria Arrests their Motility Prior to Mitophagy


Thursday, March 22 | 2:30PM - 3:30PM
Workshop 2: Mitochondria on the Move
This session is from Mitochondria
Room: Van Horne A-B

Speaker 5 of 5
Romain Cartoni, Children's Hospital Boston, Harvard Medical School, USA
Co-Deletion of PTEN and SOCS3 Enhance Mitochondrial Transport after Axonal Injury


Thursday, March 22 | 3:30PM - 4:30PM
Workshop 3: Mitochondria and Endoplasmic Reticulum: Structur
al and Functional Interplay
This session is from Mitochondria
Room: Van Horne A-B

Speaker 1 of 5
* Gia K. Voeltz, University of Colorado Boulder, USA


Thursday, March 22 | 3:30PM - 4:30PM
Workshop 3: Mitochondria and Endoplasmic Reticulum: Structur
al and Functional Interplay
This session is from Mitochondria
Room: Van Horne A-B

Speaker 2 of 5
Laura L. Lackner, Northwestern University, USA
An ER-Associated Mitochondria-Cortex Tether Functions in the Distribution and Inheritance of Mitochondria


Thursday, March 22 | 3:30PM - 4:30PM
Workshop 3: Mitochondria and Endoplasmic Reticulum: Structur
al and Functional Interplay
This session is from Mitochondria
Room: Van Horne A-B

Speaker 3 of 5
Valentina Debattisti, Thomas Jefferson University, USA
Marf, the Single Mitofusin of D. Melanogaster, is Selectively Complemented by Mitofusin 2


Thursday, March 22 | 3:30PM - 4:30PM
Workshop 3: Mitochondria and Endoplasmic Reticulum: Structur
al and Functional Interplay
This session is from Mitochondria
Room: Van Horne A-B

Speaker 4 of 5
Heather M. Lamb, Johns Hopkins Bloomberg School of Public Health, USA
Coexpression of Bax and Bcl-xL in the Secretory Pathway Alters ER Structure


Thursday, March 22 | 3:30PM - 4:30PM
Workshop 3: Mitochondria and Endoplasmic Reticulum: Structur
al and Functional Interplay
This session is from Mitochondria
Room: Van Horne A-B

Speaker 5 of 5
Clement A. Gautier, Institut du Cerveau et de la moelle Epiniere, France
Novel Role for Parkin in the Regulation of the Physical and Functional Interactions between Mitochondria and the Endoplasmic Reticulum


Thursday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, March 22 | 5:00PM - 7:15PM
Cell Death Therapeutics
Room: Van Horne C

Speaker 1 of 6
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Thursday, March 22 | 5:00PM - 7:15PM
Cell Death Therapeutics
Room: Van Horne C

Speaker 2 of 6
Carol M. Troy, Columbia University Medical Center, USA
Intranasal Cell Permeant Caspase Inhibitors – Therapeutics for Cerebral Ischemia and other Neurologic Disorders

Thursday, March 22 | 5:00PM - 7:15PM
Cell Death Therapeutics
Room: Van Horne C

Speaker 3 of 6
Loren D. Walensky, Dana-Farber Cancer Institute, USA
Mining the Repertoire of BH3 Interaction Sites for Next Generation Pro-Apoptotic Therapies

Thursday, March 22 | 5:00PM - 7:15PM
Cell Death Therapeutics
Room: Van Horne C

Speaker 4 of 6
Rajiv R. Ratan, Burke-Cornell Medical Research Institute, USA
Epigenetic Modifiers Prevent Neurodegeneration: HDACs and Beyond

Thursday, March 22 | 5:00PM - 7:15PM
Cell Death Therapeutics
Room: Van Horne C

Speaker 5 of 6
Liane Wagner, University Medical Center Ulm, Germany
Short Talk: Smac Mimetic Sensitizes Glioblastoma Cells to Temozolomide-Induced Apoptosis via Ripoptosome Formation

Thursday, March 22 | 5:00PM - 7:15PM
Cell Death Therapeutics
Room: Van Horne C

Speaker 6 of 6
Johannes Noack, DKFZ - German Cancer Research Center, Germany
Short Talk: Combination of a Sphingosine Kinase Inhibitor and Temozolomide Results in a Strong Synergistic Cytotoxic Effect which Displays Features of Various Cell Death Pathways

Thursday, March 22 | 5:00PM - 7:00PM
The Interface between Mitochondria, Metabolism and Cell Deat
h
This session is from Mitochondria

Room: Van Horne A-B

Speaker 1 of 5
* Paolo Bernardi, University of Padova Medical School, Italy


Thursday, March 22 | 5:00PM - 7:00PM
The Interface between Mitochondria, Metabolism and Cell Deat
h
This session is from Mitochondria

Room: Van Horne A-B

Speaker 2 of 5
Vamsi K. Mootha, Massachusetts General Hospital, USA
Discovery of the Mitochondrial Calcium Uniporter via Genomics


Thursday, March 22 | 5:00PM - 7:00PM
The Interface between Mitochondria, Metabolism and Cell Deat
h
This session is from Mitochondria

Room: Van Horne A-B

Speaker 3 of 5
Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Mitochondrial Control of Autophagy


Thursday, March 22 | 5:00PM - 7:00PM
The Interface between Mitochondria, Metabolism and Cell Deat
h
This session is from Mitochondria

Room: Van Horne A-B

Speaker 4 of 5
Nika N. Danial, Dana-Farber Cancer Institute, USA
Programming the Mitochondrial Carbon Substrate Utilization: A Role for BAD


Thursday, March 22 | 5:00PM - 7:00PM
The Interface between Mitochondria, Metabolism and Cell Deat
h
This session is from Mitochondria

Room: Van Horne A-B

Speaker 5 of 5
Christian Frezza, Hutchison/MRC Research Centre, UK
Short Talk: Haem Oxygenase is Synthetically Lethal with the Tumor Suppressor Fumarate Hydratase


Thursday, March 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Thursday, March 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Mezzanine 2


Friday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 1 of 7
* Heidi M. McBride, McGill University, Canada

Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 2 of 7
Mondira Kundu, St. Jude Children's Hospital, USA
ULK1: Linking Mitophagy with the Cellular Response to Stress

Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 3 of 7
Koji Okamoto, Osaka University, Japan
Molecular Mechanism of Mitochondria-specific Autophagy in Yeast

Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 4 of 7
Paul A. Ney, New York Blood Center, USA
A Single Amino in NIX is Essential for Mitochondrial Clearance in Reticulocytes

Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 5 of 7
Richard J. Youle, NINDS, National Institutes of Health, USA
Damage Control - How the Pink1/Parkin pathway can regulate removal of impaired mitochondria by autophagy

Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 6 of 7
Rudolf J. Wiesner, University of Cologne, Germany
Short Talk: Not the Assembly, the Stability of Respiratory Chain Complexes is Impaired by Nonsense Mutations in mtDNA Encoded Respiratory Chain Subunits

Friday, March 23 | 8:00AM - 11:15AM
Mitophagy/Quality Control (Joint)
Room: Van Horne A-B

Speaker 7 of 7
Matthew J. LaVoie, Brigham and Women's Hospital and Harvard Medical School, USA
Short Talk: Parkin Ubiquitinates Bax to Regulate the Apoptotic Response of Mitochondria

Friday, March 23 | 9:00AM - 9:20AM
Coffee Break
Room: Van Horne Foyer


Friday, March 23 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
Room: Van Horne C

Speaker 1 of 8
* John J. Lemasters, Medical University of South Carolina, USA

Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
Room: Van Horne C

Speaker 2 of 8
Su-Jeong Kim, University of Southern California, USA
Nuclear Translocation of DJ-1 during Oxidative Stress-Induced Neuronal Cell Death

Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
Room: Van Horne C

Speaker 3 of 8
Devrim Gozuacik, Sabanci University, Turkey
MicroRNA Control of Autophagy

Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
Room: Van Horne C

Speaker 4 of 8
Charles A. O'Brien, University of Arkansas for Medical Sciences, USA
Osteocyte Autophagy Declines with Age in Mice and Suppression
of Osteocyte Autophagy Decreases Bone Mass and Mimics Skeletal Aging


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
Room: Van Horne C

Speaker 5 of 8
Jennifer Martinez, NIEHS, National Institutes of Health, USA
LC3-Associated Phagocytosis is Required for Efficient Clearance of Dead Cells

Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
Room: Van Horne C

Speaker 6 of 8
Babul Moni Ram, National Cancer Institute, USA
Calcineurin Inhibitor Cyclosporine A Induces Endoplasmic Reticulum Stress Mediated Non Apoptotic Cell Death Response

Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
Room: Van Horne C

Speaker 7 of 8
Melanie J. Scott, University of Pittsburgh, USA
Caspase-1-Dependent Mitophagy Regulates Liver Damage and Cell Death after Hemorrhagic Shock in Mice

Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: Autophagy in Pathological Conditions
Room: Van Horne C

Speaker 8 of 8
Melissa Vos, University of Lübeck, Germany
Vitamin K2 is a Mitochondrial Electron Carrier that Rescues Pink1 Deficiency

Friday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Friday, March 23 | 5:00PM - 7:00PM
Use and Interpretation of Assays for Monitoring Mitophagy
Room: Van Horne C

Speaker 1 of 3
* Paul A. Ney, New York Blood Center, USA

Friday, March 23 | 5:00PM - 7:00PM
Use and Interpretation of Assays for Monitoring Mitophagy
Room: Van Horne C

Speaker 2 of 3
Orian S. Shirihai, University of California, Los Angeles, USA
Live Imaging of Mitophagy in Mammalian Cells

Friday, March 23 | 5:00PM - 7:00PM
Use and Interpretation of Assays for Monitoring Mitophagy
Room: Van Horne C

Speaker 3 of 3
Hagai Abeliovich, Hebrew University of Jerusalem, Israel
Mitophagy as a Quality Control Mechanism in Saccharomyces cerevisiae

Friday, March 23 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Disease
This session is from Mitochondria
Room: Van Horne A-B

Speaker 1 of 4
* Anu Suomalainen Wartiovaara, University of Helsinki, Finland


Friday, March 23 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Disease
This session is from Mitochondria
Room: Van Horne A-B

Speaker 2 of 4
Gerald W. Dorn, II, Washington University School of Medicine, USA
The Varied Roles of Mitofusins in the Heart


Friday, March 23 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Disease
This session is from Mitochondria
Room: Van Horne A-B

Speaker 3 of 4
Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy: An Immunity Paradigm with Mitochondria as a Centerpiece


Friday, March 23 | 5:00PM - 7:00PM
Mitochondrial Dynamics and Disease
This session is from Mitochondria
Room: Van Horne A-B

Speaker 4 of 4
Michelle L. Boland, Medimmune, USA
Short Talk: Bnip3 is Required to Prevent Hepatic Steatosis and Deficiencies in Gluconeogensis through Effects at the Mitochondria


Friday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Friday, March 23 | 8:00PM - 11:00PM
Entertainment
Room: Mezzanine 2


Friday, March 23 | 8:00PM - 11:00PM
Cash Bar
Room: Mezzanine 2


Saturday, March 24 | 10:25AM - 10:25AM
Departure


*Session Chair.