Web Desc
Viral Immunity and Host Gene Influence
joint with HIV Vaccines
Organizer(s): Laurence C. Eisenlohr, Connie C. Bergmann, Stephen J. Turner and Andrea Lynn Cox
Date: March 21 - 26, 2012
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
This meeting will focus on recent advances in viral immunity and host gene influence that have most excited the scientific community. Systems biology approaches are being increasingly applied to the exploration of host-pathogen interactions, including the impact of viral infection on innate and adaptive immunity. Accordingly, the keynote talk will be on this topic. The first full session on the next day will focus on innate immunity, a field that continues to evolve rapidly and hold great interest in the field. In the evening the audience will hear from others who have successfully applied a systems biology approach to examine virus-host interactions. The second day explores adaptive immunity, a topic that historically has been a centerpiece for this meeting, and an area that continues to move forward rapidly. On the third day, the morning session will focus on immune evasion and subversion and will illustrate how formidable the opposition can be and why vaccine development for a number of important human diseases is so challenging. Talks on persistent and chronic viral infections, a topic with clear relevance to a number of human diseases, will be covered in the evening session. The morning session of the final day will cover immune tailoring in non-lymphoid tissues; talks will illustrate how different host responses can and must be, depending upon anatomical location of the infection. The final session will cover the latest advances in the development of vaccines and therapeutics, the traditional ending for this meeting series and a reminder to attendees of the ultimate objectives. Overall, the objective of the Keystone Symposia meeting on Viral Immunity and Host Gene Influence is to accelerate progress in understanding and manipulating anti-viral immunity to improve human health. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on HIV Vaccines, which will share a keynote address and three plenary sessions with this meeting. We anticipate this pairing will facilitate a wider cross-fertilization of ideas and foster innovative collaborations among scientists working in vaccinology and those studying innate immune mechanisms and other viral diseases.
Scholarship Deadline: November 21 2011
Discounted Abstract Deadline: November 21 2011
Abstract Deadline: December 22 2011
Discounted Registration Deadline: January 20 2012
We gratefully acknowledge additional support for this conference from:
Biogen Idec
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Crucell


Julien Guergnon
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI098254-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, March 21 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Wednesday, March 21 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Wednesday, March 21 | 7:15PM - 7:30PM
Welcome Address by the Organizers (Joint)
Room: Columbine Ballroom

Speaker 1 of 2
Gunilla B. Karlsson Hedestam, Karolinska Institutet, Sweden

Wednesday, March 21 | 7:15PM - 7:30PM
Welcome Address by the Organizers (Joint)
Room: Columbine Ballroom

Speaker 2 of 2
Laurence C. Eisenlohr, Children's Hospital of Philadelphia and University of Pennsylvania, USA

Wednesday, March 21 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 1 of 4
* Naglaa Shoukry, University of Montreal Hospital Research Center, Canada

Wednesday, March 21 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 2 of 4
* Andrew J. McMichael, Oxford University, UK

Wednesday, March 21 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 3 of 4
Stanley M. Lemon, University of North Carolina at Chapel Hill, USA
Divergent Infection Outcomes Marked by Similarities and Differences in Induction and Evasion of Interferon Responses by Hepatotropic RNA Viruses

Wednesday, March 21 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 4 of 4
Joseph G. Sodroski, Dana-Farber Cancer Institute, USA
Structure of the Membrane-Anchored HIV-1 Envelope Glycoprotein Trimer Complex by Cryoelectron Microscopy

Thursday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak


Thursday, March 22 | 8:00AM - 11:15AM
Innate Immune Responses to Virus Infection
Room: Quandary Peak

Speaker 1 of 6
Jae U. Jung, Keck School of Medicine of University of Southern California, USA
IFITM-Mediated Intracellular Anti-Viral Restriction

Thursday, March 22 | 8:00AM - 11:15AM
Innate Immune Responses to Virus Infection
Room: Quandary Peak

Speaker 2 of 6
* Mariapia A. Degli-Esposti, LEI, University of Western Australia, Australia
NK Cell Immune Mechanisms in a Natural Host-Pathogen System

Thursday, March 22 | 8:00AM - 11:15AM
Innate Immune Responses to Virus Infection
Room: Quandary Peak

Speaker 3 of 6
Andrew G. Brooks, University of Melbourne, Australia
Killer Immunoglobulin Receptor 3DL1-Mediated Recognition of HLA-A and –B Allotypes

Thursday, March 22 | 8:00AM - 11:15AM
Innate Immune Responses to Virus Infection
Room: Quandary Peak

Speaker 4 of 6
Luis J. Sigal, Fox Chase Cancer Center, USA
Innate Immunity to Ectromelia Virus

Thursday, March 22 | 8:00AM - 11:15AM
Innate Immune Responses to Virus Infection
Room: Quandary Peak

Speaker 5 of 6
Michael A. Schmid, Humabs – Vir Biotechnology, Switzerland
Short Talk: Dendritic Cells and the Immune Response to Dengue Virus Infection in the Skin

Thursday, March 22 | 8:00AM - 11:15AM
Innate Immune Responses to Virus Infection
Room: Quandary Peak

Speaker 6 of 6
Béhazine Combadiere, Centre d'Immunologie et des Maladies Infectieuses, France
Short Talk: Neutrophils Drag and Drop Antigen from the Dermis to the Bone Marrow Initiating an Alternative Source of Long-Lived Memory CD8+ T Cells

Thursday, March 22 | 8:00AM - 11:00AM
HIV-1/SIV Transmission
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 1 of 7
* Daniel C. Douek, NIAID, National Institutes of Health, USA


Thursday, March 22 | 8:00AM - 11:00AM
HIV-1/SIV Transmission
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 2 of 7
* Barbara L. Shacklett, University of California, Davis, USA


Thursday, March 22 | 8:00AM - 11:00AM
HIV-1/SIV Transmission
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 3 of 7
Beatrice H. Hahn, University of Pennsylvania, USA
Biology of Transmitted/Founder Viruses


Thursday, March 22 | 8:00AM - 11:00AM
HIV-1/SIV Transmission
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 4 of 7
Damien Tully, Ragon Institute of MGH, MIT and Harvard, USA
A Deeper View of Transmitted/Founder Viruses during Acute
HIV-1 Infection using 454 Whole Genome Deep Sequencing


Thursday, March 22 | 8:00AM - 11:00AM
HIV-1/SIV Transmission
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 5 of 7
Thomas J. Hope, Northwestern University, USA
Defining the Mechanisms of Heterosexual HIV Transmission


Thursday, March 22 | 8:00AM - 11:00AM
HIV-1/SIV Transmission
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 6 of 7
Christopher J. Miller, University of California, Davis, USA
Lessons Learned from Recapitulating the Step Trial in NHP


Thursday, March 22 | 8:00AM - 11:00AM
HIV-1/SIV Transmission
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 7 of 7
Kamini Gounder, Doris Duke Medical Research Institute, University of KwaZulu Natal, South Africa
Short Talk: Viral Evolution and Immune Escape in Gag during Acute HIV-1 Subtype C Infection


Thursday, March 22 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 22 | 11:00AM - 12:30PM
Hands On Computer Workshop on Los Alamos SEQUENCE DATABASE a
nd Tools
This session is from HIV Vaccines
Room: Castle Peaks
Maximum attendance: 60. Interested participants must sign up at the meeting on a first-come, first-serve basis.
Instructors: Brian Foley, Bette Korber and Carla Kuiken.


Thursday, March 22 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, March 22 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak


Thursday, March 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 1: HIV-1/SIV Transmission and NHP Protection Studie
s
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 1 of 10
* Eric Hunter, Emory University, USA


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 1: HIV-1/SIV Transmission and NHP Protection Studie
s
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 2 of 10
* Christopher J. Miller, University of California, Davis, USA


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 1: HIV-1/SIV Transmission and NHP Protection Studie
s
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 3 of 10
Debby Basu, Emory University, USA
Intra-Subtype C HIV-1 Superinfection Occurs Prior to Robust Neutralizing Antibody Responses in the Newly Infected Partner


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 1: HIV-1/SIV Transmission and NHP Protection Studie
s
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 4 of 10
Katja Pfafferott, Weatherall Institute of Molecular Medicine, UK
Analysis of Two Clade A Transmission Pairs with Contrasting Clinical Outcomes Suggests Contributions of the Founder Virus and Host CD8 T Cell Response to Set-Point Viremia


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 1: HIV-1/SIV Transmission and NHP Protection Studie
s
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 5 of 10
Rama Rao Amara, Emory University, USA
GM-CSF Expressed by DNA but Not MVA Enhances Prevention of Acquisition by a Heterologous Mucosal Challenge


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 1: HIV-1/SIV Transmission and NHP Protection Studie
s
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 6 of 10
Shari N. Gordon, NCI, National Institutes of Health, USA
Human Papillomavirus Pseudovirion Vaccines Delivering SIV DNA Partially Protects from Mucosal SIVmac251 Infection


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 1: HIV-1/SIV Transmission and NHP Protection Studie
s
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 7 of 10
Brian Moldt, The Scripps Research Institute, USA
Non-Fucosylated b12 has Enhanced FcyRIIIa-Mediated Antiviral Activity in vitro but Not Improved Protection against Mucosal SHIV Challenge in Macaques


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 1: HIV-1/SIV Transmission and NHP Protection Studie
s
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 8 of 10
Amarendra Pegu, NIAID, National Institutes of Health, USA
VRC01 Provides Sterilizing Protection to Non Human Primates from Mucosal SHIV Challenges


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 1: HIV-1/SIV Transmission and NHP Protection Studie
s
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 9 of 10
Adrienne E. Swanstrom, University of Pennsylvania, USA
In vitro and in vivo Characterization of a Novel Variant of SIVmac239 Lacking CD4 Tropism


Thursday, March 22 | 2:30PM - 4:30PM
Workshop 1: HIV-1/SIV Transmission and NHP Protection Studie
s
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 10 of 10
Liang Shang, University of Minnesota, USA
Natural Killer Cells Are Critical to Control Viral Infection in the Female Genital Tract of Rhesus Macaque after SIV Vaginal Challenge


Thursday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 22 | 5:00PM - 7:00PM
Systems Approaches to Virus-Host Interactions
Room: Quandary Peak

Speaker 1 of 4
Alan Aderem, Center for Infectious Disease Research, USA
A Systems Approach to Dissecting Immunity

Thursday, March 22 | 5:00PM - 7:00PM
Systems Approaches to Virus-Host Interactions
Room: Quandary Peak

Speaker 2 of 4
* Ralph S. Baric, University of North Carolina at Chapel Hill, USA
Systems Genetics and Respiratory Virus Pathogenomics

Thursday, March 22 | 5:00PM - 7:00PM
Systems Approaches to Virus-Host Interactions
Room: Quandary Peak

Speaker 3 of 4
Alison Simmons, Weatherall Institute of Molecular Medicine, UK
Early Host Responses to HIV Infection

Thursday, March 22 | 5:00PM - 7:00PM
Systems Approaches to Virus-Host Interactions
Room: Quandary Peak

Speaker 4 of 4
Nathan P. Croft, University of Melbourne, Australia
Short Talk: Quantitative Kinetics of Antigen Presentation during Viral Infection

Thursday, March 22 | 5:00PM - 7:00PM
B Cells and Neutralizing Antibodies
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 1 of 6
* Michel C. Nussenzweig, HHMI/Rockefeller University, USA


Thursday, March 22 | 5:00PM - 7:00PM
B Cells and Neutralizing Antibodies
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 2 of 6
* Michael B. Zwick, The Scripps Research Institute, USA


Thursday, March 22 | 5:00PM - 7:00PM
B Cells and Neutralizing Antibodies
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 3 of 6
David M. Tarlinton, Monash University, Australia
Memory B Cell and Plasma Cell Development in Response to Vaccination


Thursday, March 22 | 5:00PM - 7:00PM
B Cells and Neutralizing Antibodies
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 4 of 6
Dennis R. Burton, The Scripps Research Institute, USA
Neutralizing Antibody Targets on the HIV-1 Spike


Thursday, March 22 | 5:00PM - 7:00PM
B Cells and Neutralizing Antibodies
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 5 of 6
Gary J. Nabel, Sanofi, USA
Generation of Broadly Neutralizing Antibodies in an AIDS Vaccine: The End of the Beginning


Thursday, March 22 | 5:00PM - 7:00PM
B Cells and Neutralizing Antibodies
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 6 of 6
Jinghe Huang, NIAID, National Institutes of Health, USA
Short Talk: Isolation of a Broad, Potent, MPER-Specific Monoclonal Antibody with Novel Binding Characteristics


Thursday, March 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak


Thursday, March 22 | 7:30PM - 10:00PM
Poster Session 1
Room: Torreys Peak


Friday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak


Friday, March 23 | 8:00AM - 11:15AM
Stimulation of Adaptive Immune Responses (Joint)
Room: Columbine Ballroom

Speaker 1 of 8
* Mark Connors, NIAID, National Institutes of Health, USA

Friday, March 23 | 8:00AM - 11:15AM
Stimulation of Adaptive Immune Responses (Joint)
Room: Columbine Ballroom

Speaker 2 of 8
* Kevin L. Legge, University of Iowa Carver College of Medicine, USA

Friday, March 23 | 8:00AM - 11:15AM
Stimulation of Adaptive Immune Responses (Joint)
Room: Columbine Ballroom

Speaker 3 of 8
Laurence C. Eisenlohr, Children's Hospital of Philadelphia and University of Pennsylvania, USA
MHC Class II-Restricted Processing Pathways for Viral Antigens

Friday, March 23 | 8:00AM - 11:15AM
Stimulation of Adaptive Immune Responses (Joint)
Room: Columbine Ballroom

Speaker 4 of 8
Chris C. Norbury, Pennsylvania State University Medical School, USA
Short Talk: Assessing the Role of APC Phenotype and Maturation Status upon the Contribution of Direct and Cross Antigen Presentation during a Natural Virus Infection

Friday, March 23 | 8:00AM - 11:15AM
Stimulation of Adaptive Immune Responses (Joint)
Room: Columbine Ballroom

Speaker 5 of 8
Gunilla B. Karlsson Hedestam, Karolinska Institutet, Sweden
Properties of B Cell Responses Elicited By Soluble HIV-1 Env Trimers

Friday, March 23 | 8:00AM - 11:15AM
Stimulation of Adaptive Immune Responses (Joint)
Room: Columbine Ballroom

Speaker 6 of 8
Laura E. McCoy, University College London, UK
Short Talk: Potent Multi-Clade Neutralization of HIV-1 by a Llama VHH Antibody Induced by Immunization

Friday, March 23 | 8:00AM - 11:15AM
Stimulation of Adaptive Immune Responses (Joint)
Room: Columbine Ballroom

Speaker 7 of 8
Marc K. Jenkins, University of Minnesota Medical School, USA
Maintenance of Protective CD4+ “Memory” T Cells during Persistent Phagosomal Infection

Friday, March 23 | 8:00AM - 11:15AM
Stimulation of Adaptive Immune Responses (Joint)
Room: Columbine Ballroom

Speaker 8 of 8
David Price, Cardiff University School of Medicine, UK
The Clonotypic Basis of Adaptive T Cell Immunity

Friday, March 23 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Friday, March 23 | 11:15AM - 12:45PM
Hands On Computer Workshop on Los Alamos IMMUNOLOGY DATABASE
and Tools
This session is from HIV Vaccines
Room: Castle Peaks
Maximum attendance: 60. Interested participants must sign up at the meeting on a first-come, first-serve basis.
Instructors: Brian Foley, Bette Korber and Carla Kuiken.


Friday, March 23 | 11:45AM - 11:45AM
On Own for Lunch and Recreation


Friday, March 23 | 11:45AM - 1:00PM
Poster Setup
Room: Torreys Peak


Friday, March 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Friday, March 23 | 2:30PM - 4:30PM
Workshop 1
Room: Quandary Peak

Speaker 1 of 8
Sophie Hambleton, Newcastle University, UK
A Defect in Type I Interferon Signaling Causes Severe Susceptibility to Some, but Not All, Viral Infections in Humans

Friday, March 23 | 2:30PM - 4:30PM
Workshop 1
Room: Quandary Peak

Speaker 2 of 8
Tao Peng, University of Washington, USA
System Biology Approaches to Dissect Immune-Surveillance Roles of CD8+ Cells at Mucosal Surface during HSV-2 Reactivation

Friday, March 23 | 2:30PM - 4:30PM
Workshop 1
Room: Quandary Peak

Speaker 3 of 8
Daniela Weiskopf, La Jolla Institute for Immunology, USA
Proteome Wide Mapping of Dengue Virus-Specific T Cell Responses in Human Donors Reveals Antigenic Hot Spots and a Dominance of HLA B Restricted Responses

Friday, March 23 | 2:30PM - 4:30PM
Workshop 1
Room: Quandary Peak

Speaker 4 of 8
* Michelle L. Baker, CSIRO Livestock Industries, Australia
Immunology of an Important Viral Reservoir, the Australian Black Flying Fox

Friday, March 23 | 2:30PM - 4:30PM
Workshop 1
Room: Quandary Peak

Speaker 5 of 8
* Andrew J. Yates, Columbia University, USA
The Race for the Prize – Surveillance Strategies for the Efficient Induction of T Cell Responses

Friday, March 23 | 2:30PM - 4:30PM
Workshop 1
Room: Quandary Peak

Speaker 6 of 8
Allison M. W. Malloy, Uniformed Services University of the Health Sciences, USA
CD8+ T Cell Epitope Hierarchy is Established during the Neonatal Period in Respiratory Syncytial Virus-Infected Mice

Friday, March 23 | 2:30PM - 4:30PM
Workshop 1
Room: Quandary Peak

Speaker 7 of 8
Christopher Lupfer, St. Jude Children's Research Hospital, USA
T Cell Intrinsic Role of Nod2 in Cellular Immunity to Virus Infection

Friday, March 23 | 2:30PM - 4:30PM
Workshop 1
Room: Quandary Peak

Speaker 8 of 8
Shiki Takamura, Kinki University Faculty of Medicine, Japan
CD69 Controls a Balance between S1P- and CXCL16-Induced Chemotaxes during the Process of Memory CD8+ T Cell Recruitment to the Lung Airways

Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cells and Neutralizing Antibodies
This session is from HIV Vaccines

Speaker 1 of 10
* Nicole A. Doria-Rose, NIAID, National Institutes of Health, USA


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cells and Neutralizing Antibodies
This session is from HIV Vaccines

Speaker 2 of 10
* James A. Hoxie, University of Pennsylvania, USA


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cells and Neutralizing Antibodies
This session is from HIV Vaccines

Speaker 3 of 10
Torben Schiffner, The Scripps Research Institute, USA
Modulating Immunogenicity by Chemical Modification of gp140


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cells and Neutralizing Antibodies
This session is from HIV Vaccines

Speaker 4 of 10
Mattias Forsell, Umeå University, Sweden
Targeted Immunosilencing Reveals Independent Regulation of Epitope Specific B Cell Responses to HIV-1 Env


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cells and Neutralizing Antibodies
This session is from HIV Vaccines

Speaker 5 of 10
Elise Landais, International AIDS Vaccine Initiative, USA
Development of Broadly Neutralizing Antibody Responses in a Large Sub-Saharan HIV Primary Infection Cohorts


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cells and Neutralizing Antibodies
This session is from HIV Vaccines

Speaker 6 of 10
Jason S. McLellan, University of Texas at Austin, USA
Structural and Biophysical Studies of Antibodies Isolated from RV144 Vaccinees


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cells and Neutralizing Antibodies
This session is from HIV Vaccines

Speaker 7 of 10
Lawrence S. Shapiro, Columbia University, USA
Deep Sequencing with Longitudinal Sampling of a VRC01-Like-Antibody Response in a Chronically Infected Individual


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cells and Neutralizing Antibodies
This session is from HIV Vaccines

Speaker 8 of 10
Jordan R. Willis, Vanderbilt University, USA
Structure Analysis of Healthy Donor Repertoire Confers Sequences that Match Long Complementary Determining Regions of Broadly Neutralizing Antibodies


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cells and Neutralizing Antibodies
This session is from HIV Vaccines

Speaker 9 of 10
Samantha J. Hoot, Seattle Biomedical Research Institute, USA
Interaction of Germline Precursors to Broadly Neutralizing Anti-CD4 Binding Site Antibodies with HIV-1 Envelope Glycoproteins


Friday, March 23 | 2:30PM - 4:30PM
Workshop 2: B Cells and Neutralizing Antibodies
This session is from HIV Vaccines

Speaker 10 of 10
M. Gordon Joyce, US Military HIV Research Program, USA
Structures of Reverted Germline VRC01-Like Antibodies Guide HIV-1 Immunogen Design


Friday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Friday, March 23 | 5:00PM - 7:00PM
Adaptive Immunity: Regulating T Cell Function at the Levels
of Epigenetics and TCR Activation

Room: Quandary Peak

Speaker 1 of 4
Pedro R. Lowenstein, University of Michigan School of Medicine, USA
CD8 TcR Synapses in vitro and in vivo

Friday, March 23 | 5:00PM - 7:00PM
Adaptive Immunity: Regulating T Cell Function at the Levels
of Epigenetics and TCR Activation

Room: Quandary Peak

Speaker 2 of 4
Heather D. Hickman, NIAID, National Institutes of Health, USA
Intravital Imaging of CD8+ T Cell Activation after Viral Infection

Friday, March 23 | 5:00PM - 7:00PM
Adaptive Immunity: Regulating T Cell Function at the Levels
of Epigenetics and TCR Activation

Room: Quandary Peak

Speaker 3 of 4
* Stephen J. Turner, Monash University, Australia
Epigenetic Regulation of Virus-Specific CD8+ T Cell Responses

Friday, March 23 | 5:00PM - 7:00PM
Adaptive Immunity: Regulating T Cell Function at the Levels
of Epigenetics and TCR Activation

Room: Quandary Peak

Speaker 4 of 4
J. Scott Hale, University of Utah, USA
Short Talk: Distinct Memory CD4 T Cells with Commitment to the T Follicular Helper and Th1 Lineages

Friday, March 23 | 5:00PM - 7:00PM
Cellular Immunity against HIV/SIV - Messages for Vaccines
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 1 of 6
* Nilu Goonetilleke, University of North Carolina at Chapel Hill, USA


Friday, March 23 | 5:00PM - 7:00PM
Cellular Immunity against HIV/SIV - Messages for Vaccines
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 2 of 6
* Guido Ferrari, Duke University Medical Center, USA


Friday, March 23 | 5:00PM - 7:00PM
Cellular Immunity against HIV/SIV - Messages for Vaccines
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 3 of 6
Marcus Altfeld, Heinrich-Pette-Institute, Germany
NK Cell Mediated Immune Pressure in HIV-1 Infection


Friday, March 23 | 5:00PM - 7:00PM
Cellular Immunity against HIV/SIV - Messages for Vaccines
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 4 of 6
Stephen J. Kent, University of Melbourne, Australia
ADCC Activity against HIV


Friday, March 23 | 5:00PM - 7:00PM
Cellular Immunity against HIV/SIV - Messages for Vaccines
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 5 of 6
David I. Watkins, University of Miami, USA
SIV-Specific T Cell Responses


Friday, March 23 | 5:00PM - 7:00PM
Cellular Immunity against HIV/SIV - Messages for Vaccines
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 6 of 6
Alessandra Noto, Lausanne University Hospital, Switzerland
Short Talk: Loss of Id2 during Chronic HIV Infection is Mediated by PD-1 Triggering and is Responsible for HIV-Specific CD8+ T Cell Exhaustion


Friday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak


Friday, March 23 | 7:30PM - 10:00PM
Poster Session 2
Room: Torreys Peak


Saturday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak


Saturday, March 24 | 8:00AM - 11:15AM
Immune Evasion and Subversion (Joint)
Room: Columbine Ballroom

Speaker 1 of 8
* Todd M. Allen, Ragon Institute of MGH, MIT and Harvard, USA

Saturday, March 24 | 8:00AM - 11:15AM
Immune Evasion and Subversion (Joint)
Room: Columbine Ballroom

Speaker 2 of 8
Ted C. Pierson, NIAID, National Institutes of Health, USA
A Dynamic Landscape for Antibody-Mediated Neutralization and Enhancement of Flavivirus Infection

Saturday, March 24 | 8:00AM - 11:15AM
Immune Evasion and Subversion (Joint)
Room: Columbine Ballroom

Speaker 3 of 8
* Klaus Früh, Oregon Health & Science University, USA
Evasion of T Cell Responses by Cytomegalovirus

Saturday, March 24 | 8:00AM - 11:15AM
Immune Evasion and Subversion (Joint)
Room: Columbine Ballroom

Speaker 4 of 8
Hanneke Schuitemaker, Janssen Vaccines & Prevention B.V., Netherlands
HIV-1 Dynamics in Relation to Cross-Reactive Neutralizing Humoral Immunity

Saturday, March 24 | 8:00AM - 11:15AM
Immune Evasion and Subversion (Joint)
Room: Columbine Ballroom

Speaker 5 of 8
Nilu Goonetilleke, University of North Carolina at Chapel Hill, USA
Short Talk: T Cell Immunodominance, Breadth and Epitope Entropy are the Major Determinants of Virus Escape in Acute HIV-1 Infection

Saturday, March 24 | 8:00AM - 11:15AM
Immune Evasion and Subversion (Joint)
Room: Columbine Ballroom

Speaker 6 of 8
Andrew J. McMichael, Oxford University, UK
HIV-1 Escape from CD8+ T Cell Recognition

Saturday, March 24 | 8:00AM - 11:15AM
Immune Evasion and Subversion (Joint)
Room: Columbine Ballroom

Speaker 7 of 8
Timothy E. Dudek, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Accurate Recapitulation of Human Acute-Phase HIV-Specific CD8+ T-Cell Responses and Viral Evolution in Humanized BLT Mice

Saturday, March 24 | 8:00AM - 11:15AM
Immune Evasion and Subversion (Joint)
Room: Columbine Ballroom

Speaker 8 of 8
Kia Katchar, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Adaptation of Hepatitis C Virus (HCV) to KIR-Associated Immune Pressures

Saturday, March 24 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Saturday, March 24 | 11:15AM - 11:45AM
The Grant Submission Process at NIH/NIAID (Joint)
Room: Columbine Ballroom
The presentation will introduce the NIH/NIAID grant submission process and describe some grants available to new investigators.
Speaker 1 of 1
Cheryl Lapham, NIAID, National Institutes of Health, USA

Saturday, March 24 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak


Saturday, March 24 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Saturday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Quandary Peak

Speaker 1 of 8
Christopher Brooke, NIAID, National Institutes of Health, USA
Nine Out of Ten Influenza A Virions Can Be Wrong: The Cost of Segmentation

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Quandary Peak

Speaker 2 of 8
Michael E. Wortzman, University of Toronto, Canada
Role of CD8 T Cell Intrinsic TNF in Enhancing the Contraction of Short-Lived Effector Cells during Respiratory Influenza Virus Infection

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Quandary Peak

Speaker 3 of 8
Matthieu Daugan, INRS-Institut Armand-Frappier, Canada
Mechanisms Implicated in the Late Appearance of Neutralizing Antibodies against Lymphocytic Choriomeningitis Virus

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Quandary Peak

Speaker 4 of 8
* Mario L. Santiago, University of Colorado Denver, USA
A Single Nucleotide Polymorphism in Tetherin Promotes Retrovirus Restriction in vivo

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Quandary Peak

Speaker 5 of 8
Deepak Mittal, University of Queensland Diamantina Institute, Australia
Mechanisms of Local Immune Suppression in HPV E7 Expressing Skin

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Quandary Peak

Speaker 6 of 8
* Pinghui Feng, University of Southern California, USA
A Herpesvirus Selectively Hijacks an Innate Immune Signal Pathway to Enable Viral Transcriptional Activation and Disable Host Antiviral Cytokine Production

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Quandary Peak

Speaker 7 of 8
Amy Haseley, Ohio State University, USA
Secreted ECM Protein CCN1 Limits Oncolytic HSV-1 Efficacy for Glioma

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Quandary Peak

Speaker 8 of 8
Patrick C. Rämer, University of Zürich, Switzerland
Identification of Viral Tumor-Suppressor Using a Humanized Mouse Model of EBV Infection

Saturday, March 24 | 2:30PM - 4:30PM
Workshop 3: Cellular Immunity against SIV/HIV
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 1 of 9
* Richard A. Koup, NIAID, National Institutes of Health, USA


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 3: Cellular Immunity against SIV/HIV
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 2 of 9
* Bette Tina Marie Korber, Los Alamos National Laboratory, USA
A Comparison of Conserved Region versus Full-Length Protein T Cell Vaccines in Rhesus Monkeys Reveals No Evidence for Immunofocusing


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 3: Cellular Immunity against SIV/HIV
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 3 of 9
Karthik Shekhar, Massachusetts Institute of Technology, USA
Collective Evolution in HIV Proteins Reveals Strategies for Rational HIV Vaccine Design


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 3: Cellular Immunity against SIV/HIV
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 4 of 9
Tomas Hanke, University of Oxford, UK
Immunogenicity of a Universal HIV-1 Vaccine Vectored by DNA, MVA and ChAdV-63 in a Phase I/IIa Clinical Trial


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 3: Cellular Immunity against SIV/HIV
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 5 of 9
Daniel Claiborne, Ragon Institute of MGH, MIT, and Harvard, USA
Rare HLA-Associated Gag Polymorphisms Dramatically Reduce Replicative Capacity of Transmitted Founder Viruses and Modulate Set Point Viral Load


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 3: Cellular Immunity against SIV/HIV
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 6 of 9
Sylvie Le Gall, Massachusetts General Hospital, Harvard Medical School, USA
Sequence Signatures Define HIV Antigen Processing Mutations Leading to Immune Escape at the Population Level


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 3: Cellular Immunity against SIV/HIV
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 7 of 9
Lydie Trautmann, US Military HIV Research Program, USA
Dissecting Function, Memory Generation, and TCR Repertoire of Effector CD8 T cells in Primary HIV Infection and other Acute Viral Infections


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 3: Cellular Immunity against SIV/HIV
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 8 of 9
Srinika R. F. Ranasinghe, Ragon Institute of MGH, MIT and Harvard, USA
Promiscuity in Peptide-HLA Class II Interactions Impact HIV Immune Control


Saturday, March 24 | 2:30PM - 4:30PM
Workshop 3: Cellular Immunity against SIV/HIV
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 9 of 9
LaTonya D. Williams, Duke University Medical Center, USA
CD4-Like Immunologic Function by IL-21-Producing CD8 T Cells in HIV-Infected Individuals


Saturday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Saturday, March 24 | 5:00PM - 7:00PM
Immunity to Chronic and Persistent Viral Infections
Room: Quandary Peak

Speaker 1 of 4
Mehrdad Matloubian, University of California, San Francisco, USA
Role of Innate Sensing Pathways in Chronic Viral Infections

Saturday, March 24 | 5:00PM - 7:00PM
Immunity to Chronic and Persistent Viral Infections
Room: Quandary Peak

Speaker 2 of 4
Barbara Rehermann, NIDDK, National Institutes of Health, USA
Natural Killer Cell Function in Hepatitis C Virus Infection

Saturday, March 24 | 5:00PM - 7:00PM
Immunity to Chronic and Persistent Viral Infections
Room: Quandary Peak

Speaker 3 of 4
Christopher M. Snyder, Thomas Jefferson University, USA
Short Talk: Small Populations of Memory-Like CD8+ T Cells Undergo Memory Inflation during MCMV Infection

Saturday, March 24 | 5:00PM - 7:00PM
Immunity to Chronic and Persistent Viral Infections
Room: Quandary Peak

Speaker 4 of 4
* Andrea Lynn Cox, Johns Hopkins University, USA
The Missing Link between Inflammasome Complex Activation and Adaptive Immune Responses in the Transition from Acute to Chronic HCV Infection

Saturday, March 24 | 5:00PM - 7:00PM
Update from Clinical Trials of HIV-1 Vaccines
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 1 of 6
* Lawrence Corey, Fred Hutchinson Cancer Research Center, USA


Saturday, March 24 | 5:00PM - 7:00PM
Update from Clinical Trials of HIV-1 Vaccines
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 2 of 6
* Amapola Manrique, Global HIV Vaccine Enterprise, USA


Saturday, March 24 | 5:00PM - 7:00PM
Update from Clinical Trials of HIV-1 Vaccines
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 3 of 6
Nicole Frahm, Bill & Melinda Gates Medical Research Institute, USA
The HIV Vaccine Landscape after Step and RV144


Saturday, March 24 | 5:00PM - 7:00PM
Update from Clinical Trials of HIV-1 Vaccines
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 4 of 6
Nelson L. Michael, Walter Reed Army Institute of Research, USA
Thai Phase III Update. RV144 Follow-up: Antigenicity, Correlates, and Sieve Analysis


Saturday, March 24 | 5:00PM - 7:00PM
Update from Clinical Trials of HIV-1 Vaccines
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 5 of 6
Susan Zolla-Pazner, Icahn School of Medicine at Mount Sinai, USA
Antibodies, Variable Regions, and the RV144 Vaccine Trial Results


Saturday, March 24 | 5:00PM - 7:00PM
Update from Clinical Trials of HIV-1 Vaccines
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 6 of 6
Amy W. Chung, Ragon Institute of MGH, MIT & Harvard, USA
Short Talk: RV144 Vaccine Induces a Differential Antibody Effector Function Profile in Comparison to VAX003


Saturday, March 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak


Saturday, March 24 | 7:30PM - 10:00PM
Poster Session 3
Room: Torreys Peak


Sunday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Torreys Peak


Sunday, March 25 | 8:00AM - 11:15AM
Immune Tailoring in Non-Lymphoid Tissues
Room: Quandary Peak

Speaker 1 of 6
Mark T. Heise, University of North Carolina at Chapel Hill, USA
Systems Genetics and Regulation of Virus-Induced Inflammatory Responses

Sunday, March 25 | 8:00AM - 11:15AM
Immune Tailoring in Non-Lymphoid Tissues
Room: Quandary Peak

Speaker 2 of 6
David L. Woodland, Keystone Symposia on Molecular and Cellular Biology, USA
Lung Specific Recruitment of Virus-Specific T Cells during Acute Respiratory Infection

Sunday, March 25 | 8:00AM - 11:15AM
Immune Tailoring in Non-Lymphoid Tissues
Room: Quandary Peak

Speaker 3 of 6
Yoshimasa Takahashi, National Institute of Infectious Diseases, Japan
Short Talk: Memory B Cells in the Lung Participate in Protective Humoral Immune Responses to Pulmonary Influenza Virus Reinfection

Sunday, March 25 | 8:00AM - 11:15AM
Immune Tailoring in Non-Lymphoid Tissues
Room: Quandary Peak

Speaker 4 of 6
* Cornelia C. Bergmann, Cleveland Clinic Foundation, USA
Cell Type-Specific Immune Regulation during Viral Encephalomyelitis

Sunday, March 25 | 8:00AM - 11:15AM
Immune Tailoring in Non-Lymphoid Tissues
Room: Quandary Peak

Speaker 5 of 6
Jasmin Herz, University of Virginia, USA
Short Talk: Dynamics of Memory T Cells Clearing a Persistent Infection in the Absence of Severe Tissue Injury

Sunday, March 25 | 8:00AM - 11:15AM
Immune Tailoring in Non-Lymphoid Tissues
Room: Quandary Peak

Speaker 6 of 6
Robert L. Hendricks, University of Pittsburgh, USA
Manipulating HSV-Specific CD8+ T Cell Function to Control Latent Infections in Sensory Gangli

Sunday, March 25 | 8:00AM - 11:00AM
Effective Immune Responses in Animal Models
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 1 of 6
* James E. Robinson, Tulane University Health Sciences Center, USA


Sunday, March 25 | 8:00AM - 11:00AM
Effective Immune Responses in Animal Models
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 2 of 6
* Nancy R. Miller, NIAID, National Institutes of Health, USA


Sunday, March 25 | 8:00AM - 11:00AM
Effective Immune Responses in Animal Models
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 3 of 6
Jason M. Brenchley, NIAID, National Institutes of Health, USA
Microbial Translocation, Immune Activation, and Disease Progression


Sunday, March 25 | 8:00AM - 11:00AM
Effective Immune Responses in Animal Models
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 4 of 6
Poonam Pegu, NCI, National Institutes of Health, USA
Short Talk: Mucosal Transmission of a Limited Number of SIVmac251 Variants in Macaques Recapitulates HIV Vaccine Efficacy in Humans


Sunday, March 25 | 8:00AM - 11:00AM
Effective Immune Responses in Animal Models
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 5 of 6
Richard T. Wyatt, IAVI Neutralizing Antibody Center, The Scripps Research Institute, USA
Analysis of HIV-1 Env and Elicited Antibody Responses for Improved Immunogen Design


Sunday, March 25 | 8:00AM - 11:00AM
Effective Immune Responses in Animal Models
This session is from HIV Vaccines
Room: Longs/Grays Peaks

Speaker 6 of 6
Nancy L. Haigwood, Oregon Health & Science University, USA
Clues to Understanding the Role and Impact of Eliciting Neutralizing Antibodies


Sunday, March 25 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Sunday, March 25 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Sunday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Sunday, March 25 | 5:00PM - 7:00PM
New Concepts Guiding Vaccine Development (Joint)
Room: Columbine Ballroom

Speaker 1 of 5
* Gunilla B. Karlsson Hedestam, Karolinska Institutet, Sweden

Sunday, March 25 | 5:00PM - 7:00PM
New Concepts Guiding Vaccine Development (Joint)
Room: Columbine Ballroom

Speaker 2 of 5
* Laurence C. Eisenlohr, Children's Hospital of Philadelphia and University of Pennsylvania, USA

Sunday, March 25 | 5:00PM - 7:00PM
New Concepts Guiding Vaccine Development (Joint)
Room: Columbine Ballroom

Speaker 3 of 5
Shane Crotty, La Jolla Institute for Immunology, USA
Designing Vaccines: Follicular Helper CD4 T Cells and their Roles in Generating Neutralizing Antibody Responses

Sunday, March 25 | 5:00PM - 7:00PM
New Concepts Guiding Vaccine Development (Joint)
Room: Columbine Ballroom

Speaker 4 of 5
Robert A. Seder, NIAID, National Institutes of Health, USA
Impact of Adjuvants on HIV-Specific Immune Responses

Sunday, March 25 | 5:00PM - 7:00PM
New Concepts Guiding Vaccine Development (Joint)
Room: Columbine Ballroom

Speaker 5 of 5
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Human Antibodies to HIV

Sunday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak


Sunday, March 25 | 8:00PM - 11:00PM
Entertainment
Room: Torreys Peak


Sunday, March 25 | 8:00PM - 11:00PM
Cash Bar
Room: Torreys Peak


Monday, March 26 | 10:25AM - 10:25AM
Departure


*Session Chair.