Web Desc
Cell Biology of Virus Entry, Replication and Pathogenesis
joint with Frontiers in HIV Pathogenesis, Therapy and Eradication
Organizer(s): Michael Farzan, Benhur Lee and Judith M. White
Date: March 26 - 31, 2012
Location: Whistler Conference Centre, Whistler, BC, Canada
Sponsored by Gilead Sciences, Inc. and MedImmune
For important information on the coronavirus, please click here
Summary of Meeting:
This meeting will highlight recent advances in virus infection pathways, and in the cellular responses to viral infection. The meeting features multiple stages of the viral lifecycle analyzed using a broad array of techniques and levels of analysis. A novel feature of this meeting is that it will be held concurrently with the Keystone Symposia meeting on Frontiers in HIV Pathogenesis, Therapy and Eradication and will, therefore, focus on maximizing exchange between the HIV community and the broader community of virologists. An explicit goal is to bring together and promote potential synergies among researchers who might not otherwise interact in more specialized meetings. A classic, almost paradigmatic, example of the power of this cross-talk is the contribution of studies of influenza A virus hemagglutinin to our understanding of the HIV-1 entry process, and the subsequent contribution of both systems to our understanding of type I fusion, type II fusion and the entry processes of non-enveloped viruses. Accordingly, two common sessions will focus on the retroviral entry process and its inhibition, followed by talks featuring a broader survey of viral entry, replication, structural and systems approaches to virology, host immune evasion and therapeutics.
Scholarship Deadline: November 29 2011
Discounted Abstract Deadline: November 29 2011
Abstract Deadline: January 4 2012
Discounted Registration Deadline: January 26 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Gilead Sciences, Inc.MedImmune
We gratefully acknowledge additional support for this conference from:
ImQuest BioSciences
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

MedImmune

Merck Research Laboratories


Wen Chang, in memory of Frank Fenner
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI098314-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, March 26 | 3:00PM - 7:30PM
Registration
Room: Grand Foyer


Monday, March 26 | 6:15PM - 7:15PM
Refreshments
Room: Grand Foyer


Monday, March 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 1 of 4
* Alan N. Engelman, Dana-Farber Cancer Institute, USA

Monday, March 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 2 of 4
* Michael Farzan, The Scripps Research Institute, USA

Monday, March 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 3 of 4
Robert F. Siliciano, Johns Hopkins University School of Medicine, USA
Understanding How Antiretroviral Therapy for HIV Infection Really Works

Monday, March 26 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 4 of 4
Stephen C. Harrison, Harvard Medical School, USA
Mechanisms of Virus Entry

Tuesday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A, Garibaldi B/C


Tuesday, March 27 | 8:00AM - 11:15AM
Retroviral Entry Mechanisms (Joint)
Room: Sea to Sky B/C

Speaker 1 of 7
* Peter D. Kwong, NIAID, National Institutes of Health, USA

Tuesday, March 27 | 8:00AM - 11:15AM
Retroviral Entry Mechanisms (Joint)
Room: Sea to Sky B/C

Speaker 2 of 7
Sriram Subramaniam, University of British Columbia, Canada
Structure of HIV and SIV Envelope Glycoproteins and Mechanisms of Viral Entry

Tuesday, March 27 | 8:00AM - 11:15AM
Retroviral Entry Mechanisms (Joint)
Room: Sea to Sky B/C

Speaker 3 of 7
Kelly K. Lee, University of Washington, USA
Short Talk: Solution Structure and Conformational Dynamics in Full-Length, Glycosylated HIV Gp120

Tuesday, March 27 | 8:00AM - 11:15AM
Retroviral Entry Mechanisms (Joint)
Room: Sea to Sky B/C

Speaker 4 of 7
Thomas J. Hope, Northwestern University, USA
HIV in the Cytoplasm: How Can Early Events Influence Late Outcomes?

Tuesday, March 27 | 8:00AM - 11:15AM
Retroviral Entry Mechanisms (Joint)
Room: Sea to Sky B/C

Speaker 5 of 7
Michael J. Root, Thomas Jefferson University, USA
HIV-1 gp41 Structural Changes Associated with Viral Membrane Fusion

Tuesday, March 27 | 8:00AM - 11:15AM
Retroviral Entry Mechanisms (Joint)
Room: Sea to Sky B/C

Speaker 6 of 7
Clare Jolly, University College London, UK
Cell-Cell Transfer of HIV-1

Tuesday, March 27 | 8:00AM - 11:15AM
Retroviral Entry Mechanisms (Joint)
Room: Sea to Sky B/C

Speaker 7 of 7
Kelechi C. Chikere, University of California, Los Angeles, USA
Short Talk: High Throughput Receptor Affinity Profiling Reveals Distinct Entry Efficiency Patterns amongst HIV-1 Isolates that Correlate with Pathogenic and Biological Phenotypes

Tuesday, March 27 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Tuesday, March 27 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Tuesday, March 27 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 1: New Approaches to the Study of Treatment of Vira
l Infections
Room: Sea to Sky C

Speaker 1 of 9
* Benhur Lee, University of California, Los Angeles, USA

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 1: New Approaches to the Study of Treatment of Vira
l Infections
Room: Sea to Sky C

Speaker 2 of 9
Aaron J. Arvey, Gilead, USA
Profiling the Genome-Wide Regulatory Network of a Tumor Virus and Its Human Host

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 1: New Approaches to the Study of Treatment of Vira
l Infections
Room: Sea to Sky C

Speaker 3 of 9
Benjamin K. Chen, Mount Sinai School of Medicine, USA
Coupled HIV-1 Endocytosis and Maturation-Induced Viral Fusion during Cell-Cell Infection

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 1: New Approaches to the Study of Treatment of Vira
l Infections
Room: Sea to Sky C

Speaker 4 of 9
Daniel C. DiMaio, Yale University School of Medicine, USA
Artificial Transmembrane Proteins that Inhibit CCR5 Expression and HIV Co-Receptor Activity

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 1: New Approaches to the Study of Treatment of Vira
l Infections
Room: Sea to Sky C

Speaker 5 of 9
J. Nicholas Francis, University of Utah, USA
Membrane Localization of D-Peptide HIV Entry Inhibitors

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 1: New Approaches to the Study of Treatment of Vira
l Infections
Room: Sea to Sky C

Speaker 6 of 9
Tijana Ivanovic, Harvard Medical School, USA
Dissecting Conformational Rearrangements in Influenza-Virus Hemagglutinin through a Single-Virion Membrane-Fusion Assay

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 1: New Approaches to the Study of Treatment of Vira
l Infections
Room: Sea to Sky C

Speaker 7 of 9
Jason Kindrachuk, National Institutes of Health, USA
Temporal Systems Kinomics Analysis of Host Cell Responses to Ebola

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 1: New Approaches to the Study of Treatment of Vira
l Infections
Room: Sea to Sky C

Speaker 8 of 9
Emma-Kate Loveday, University of British Columbia, Canada
Temporal and Strain-Specific Host MicroRNA Molecular Signatures Associated with Swine-Origin H1N1 and Avian-Origin H7N7 Influenza A Virus Infection

Tuesday, March 27 | 2:30PM - 4:30PM
Workshop 1: New Approaches to the Study of Treatment of Vira
l Infections
Room: Sea to Sky C

Speaker 9 of 9
Jason A. Wojcechowskyj, University of Pennsylvania, USA
How HIV Reprograms Cells - Quantitative Phosphoproteomics during HIV Entry

Tuesday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Tuesday, March 27 | 5:00PM - 7:00PM
Inhibition of Virus Entry (Joint)
Room: Sea to Sky B/C

Speaker 1 of 5
* Amy Jacobs, State University of New York at Buffalo, USA

Tuesday, March 27 | 5:00PM - 7:00PM
Inhibition of Virus Entry (Joint)
Room: Sea to Sky B/C

Speaker 2 of 5
Peter D. Kwong, NIAID, National Institutes of Health, USA
Effective Antibody-Mediated Inhibition of HIV-1 Entry

Tuesday, March 27 | 5:00PM - 7:00PM
Inhibition of Virus Entry (Joint)
Room: Sea to Sky B/C

Speaker 3 of 5
Peter S. Kim, Stanford University, USA
Vaccine Candidates that Mimic the HIV-1 gp41 Pre-Hairpin Intermediate

Tuesday, March 27 | 5:00PM - 7:00PM
Inhibition of Virus Entry (Joint)
Room: Sea to Sky B/C

Speaker 4 of 5
Michael Farzan, The Scripps Research Institute, USA
The Sulfotyrosine-Binding Pockets of gp120 as a Therapeutic Target

Tuesday, March 27 | 5:00PM - 7:00PM
Inhibition of Virus Entry (Joint)
Room: Sea to Sky B/C

Speaker 5 of 5
Jie Xue, Stanford University, USA
Short Talk: Biochemical Investigation of the Mechanism of Griffithsin: Dimer Structure Plays an Essential Role in Griffithsin Function

Tuesday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Tuesday, March 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Wednesday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A, Garibaldi B/C


Wednesday, March 28 | 8:00AM - 11:00AM
Anti-Viral Therapeutics: New and Old Paradigms
Room: Sea to Sky C

Speaker 1 of 5
* Kartik Chandran, Albert Einstein College of Medicine, USA

Wednesday, March 28 | 8:00AM - 11:00AM
Anti-Viral Therapeutics: New and Old Paradigms
Room: Sea to Sky C

Speaker 2 of 5
Benhur Lee, University of California, Los Angeles, USA
Mechanistic Basis of Broad Spectrum Antivirals that Target Virus-Cell Fusion

Wednesday, March 28 | 8:00AM - 11:00AM
Anti-Viral Therapeutics: New and Old Paradigms
Room: Sea to Sky C

Speaker 3 of 5
Benjamin R. TenOever, Icahn School of Medicine at Mount Sinai, USA
miRNA-Mediated Control of Virus Infection

Wednesday, March 28 | 8:00AM - 11:00AM
Anti-Viral Therapeutics: New and Old Paradigms
Room: Sea to Sky C

Speaker 4 of 5
JoAnn A. Suzich, AstraZeneca, USA
Treating Respiratory Syncytial Virus Infections

Wednesday, March 28 | 8:00AM - 11:00AM
Anti-Viral Therapeutics: New and Old Paradigms
Room: Sea to Sky C

Speaker 5 of 5
Phoebe L. Stewart, Case Western Reserve University, USA
Defensin Neutralization of Adenovirus

Wednesday, March 28 | 8:00AM - 11:15AM
Mechanisms of HIV Latency
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 1 of 7
* David M. Margolis, University of North Carolina at Chapel Hill, USA


Wednesday, March 28 | 8:00AM - 11:15AM
Mechanisms of HIV Latency
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 2 of 7
Eric M. Verdin, Buck Institute for Research on Aging, USA
Roles of Proviral Integration Sites


Wednesday, March 28 | 8:00AM - 11:15AM
Mechanisms of HIV Latency
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 3 of 7
Melanie M. Ott, Gladstone Institutes, USA
Regulation of HIV-1 Transcription by Tat Posttranslational Modifications


Wednesday, March 28 | 8:00AM - 11:15AM
Mechanisms of HIV Latency
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 4 of 7
Matthew J. Pace, University of Oxford, UK
Short Talk: Direct Infection of Resting CD4+ T Cells with HIV Leads to Not Only Integration but also Expression of Gag Proteins without Efficient Viral Spread in a Model of HIV Latency


Wednesday, March 28 | 8:00AM - 11:15AM
Mechanisms of HIV Latency
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 5 of 7
Jonathan Karn, Case Western Reserve University, USA
Control of HIV Latency by Epigenetic and Non-Epigenetic Silencing


Wednesday, March 28 | 8:00AM - 11:15AM
Mechanisms of HIV Latency
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 6 of 7
Mario Stevenson, University of Miami, Leonard M. Miller School of Medicine, USA
Tissue Analysis of Viral Reservoirs in Patients on ART


Wednesday, March 28 | 8:00AM - 11:15AM
Mechanisms of HIV Latency
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 7 of 7
Sharon Schlesinger, Columbia University, College of Physicians and Surgeons, USA
Short Talk: Proviral Silencing in Embryonic Cells: Why YY1?


Wednesday, March 28 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Wednesday, March 28 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Wednesday, March 28 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Wednesday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Wednesday, March 28 | 2:30PM - 4:30PM
Workshop 1: New Pharmacologies/Intervention
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 1 of 7
* Andrew J. Henderson, Boston University School of Medicine, USA


Wednesday, March 28 | 2:30PM - 4:30PM
Workshop 1: New Pharmacologies/Intervention
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 2 of 7
Ramesh K. Akkina, Colorado State University, USA
Topical Gel Formulation of Broadly Neutralizing Anti-HIV-1 Monoclonal Antibody VRC01 Protects against HIV-1 Vaginal Challenge in a Humanized Mouse Model


Wednesday, March 28 | 2:30PM - 4:30PM
Workshop 1: New Pharmacologies/Intervention
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 3 of 7
Li Liu, NIAID, National Institutes of Health, USA
Neutralization Epitope Masking within the Native HIV-1 Env Trimer: Intraprotomer Rather than Interprotomer Masking of V3 Epitopes by V1V2


Wednesday, March 28 | 2:30PM - 4:30PM
Workshop 1: New Pharmacologies/Intervention
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 4 of 7
Eugenio Montini, Fondazione Telethon, Italy
Assessing the Impact of Lentiviral Vector Integration on Splicing of Cellular Genes at the Genome-Wide Level


Wednesday, March 28 | 2:30PM - 4:30PM
Workshop 1: New Pharmacologies/Intervention
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 5 of 7
Webster L. Santos, Virginia Tech, USA
Inhibiting RNA-Protein Interactions: Cell Permeable Branched Peptide Boronic Acids Inhibit Tat-TAR and Rev-RRE Interactions


Wednesday, March 28 | 2:30PM - 4:30PM
Workshop 1: New Pharmacologies/Intervention
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 6 of 7
Kayoko Waki, NCI, National Institutes of Health, USA
A Tale of Two HIV-1 Maturation Inhibitors – Bevirimat (BVM) and PF-46396: Insights into Gag Assembly and Virion Maturation


Wednesday, March 28 | 2:30PM - 4:30PM
Workshop 1: New Pharmacologies/Intervention
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 7 of 7
Keith R. Jerome, Fred Hutchinson Cancer Research Center, USA
Pharmacodynamic Considerations in Targeted Endonuclease Therapy for HIV


Wednesday, March 28 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Wednesday, March 28 | 5:00PM - 7:00PM
Viral Entry Processes
Room: Sea to Sky C

Speaker 1 of 5
* Sean P. Whelan, Harvard Medical School, USA

Wednesday, March 28 | 5:00PM - 7:00PM
Viral Entry Processes
Room: Sea to Sky C

Speaker 2 of 5
Judith M. White, University of Virginia Health Sciences Center, USA
Roles for Cathepsin Priming of the Ebola Virus Glycoprotein for Cellular Entry

Wednesday, March 28 | 5:00PM - 7:00PM
Viral Entry Processes
Room: Sea to Sky C

Speaker 3 of 5
Lucas Pelkmans, University of Zürich, Switzerland
Cell-to-Cell Variability Modeling of Virus Infection Reveals Complex Population-Determined RNAi Phenotypes

Wednesday, March 28 | 5:00PM - 7:00PM
Viral Entry Processes
Room: Sea to Sky C

Speaker 4 of 5
Roselyn J. Eisenberg, University of Pennsylvania, USA
Herpes Virus Fusion and Entry: A Story with Many Characters

Wednesday, March 28 | 5:00PM - 7:00PM
Viral Entry Processes
Room: Sea to Sky C

Speaker 5 of 5
Mathieu Mateo, Mayo Clinic, USA
Short Talk: Nectin-4 is the Measles Virus Host Exit Receptor

Wednesday, March 28 | 5:00PM - 7:00PM
HIV Therapy: State of the Art
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 1 of 5
* Celia A. Schiffer, University of Massachusetts Medical School, USA


Wednesday, March 28 | 5:00PM - 7:00PM
HIV Therapy: State of the Art
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 2 of 5
Douglas D. Richman, University of California, San Diego, USA
Measuring the Latent Reservoir


Wednesday, March 28 | 5:00PM - 7:00PM
HIV Therapy: State of the Art
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 3 of 5
Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
TCR Clonotypes Modulate the Protective Effect of HLA Class I Alleles in HIV-1 Infection


Wednesday, March 28 | 5:00PM - 7:00PM
HIV Therapy: State of the Art
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 4 of 5
Tae-Wook Chun, NIAID, National Institutes of Health, USA
Cellular Reservoirs of HIV: Perspectives for Eradication and Development of Therapeutic Strategies


Wednesday, March 28 | 5:00PM - 7:00PM
HIV Therapy: State of the Art
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 5 of 5
Mathias Lichterfeld, Brigham and Women's Hospital, USA
Short Talk: Treatment of Early HIV-1 Infection Reduces Viral Reservoirs in CD4 T Cells to Levels Found in Elite Controllers


Wednesday, March 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Wednesday, March 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Thursday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A, Garibaldi B/C


Thursday, March 29 | 8:00AM - 11:00AM
Structural Approaches to Virology
Room: Sea to Sky C

Speaker 1 of 7
* Stephen C. Harrison, Harvard Medical School, USA

Thursday, March 29 | 8:00AM - 11:00AM
Structural Approaches to Virology
Room: Sea to Sky C

Speaker 2 of 7
Z. Hong Zhou, University of California, Los Angeles, USA
Atomic Structures by cryoEM Suggest Divergent Mechanisms of Entry by dsRNA Viruses

Thursday, March 29 | 8:00AM - 11:00AM
Structural Approaches to Virology
Room: Sea to Sky C

Speaker 3 of 7
Glen R. Nemerow, The Scripps Research Institute, USA
Adenovirus Structure

Thursday, March 29 | 8:00AM - 11:00AM
Structural Approaches to Virology
Room: Sea to Sky C

Speaker 4 of 7
Félix Rey, Institut Pasteur, France
The First Snapshot of a Cell-Cell Fusion Protein Reveals Unanticipated Links with Viruses

Thursday, March 29 | 8:00AM - 11:00AM
Structural Approaches to Virology
Room: Sea to Sky C

Speaker 5 of 7
Timothy F. Booth, Public Health Agency of Canada, Canada
Short Talk: Three-Dimensional Structure of Ebola Virus Determined by Cryo-Electron Microscopy and Cryo-Electron Tomography

Thursday, March 29 | 8:00AM - 11:00AM
Structural Approaches to Virology
Room: Sea to Sky C

Speaker 6 of 7
Kai Xu, National Institutes of Health, USA
Short Talk: Crystal Structure of the Nipah Virus Fusion Glycoprotein Reveals a Functionally Essential Hexameric Assembly

Thursday, March 29 | 8:00AM - 11:00AM
Structural Approaches to Virology
Room: Sea to Sky C

Speaker 7 of 7
Robin Löving, Karolinska Institutet, Sweden
Short Talk: Maturation Cleavage of the Retrovirus Mo-MLV Spike Precursor Splays the Transmembrane Subunits to Prime it for Receptor Triggering

Thursday, March 29 | 8:00AM - 11:15AM
Targeting Latency for Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 1 of 7
* Carol D. Weiss, US Food and Drug Administration, USA


Thursday, March 29 | 8:00AM - 11:15AM
Targeting Latency for Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 2 of 7
David M. Margolis, University of North Carolina at Chapel Hill, USA
Targeting Latency for Eradication: State of the Art


Thursday, March 29 | 8:00AM - 11:15AM
Targeting Latency for Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 3 of 7
Daria J. Hazuda, Merck Research Laboratories, USA
The HIV-1 Eradication Pipeline: Challenges and Opportunities


Thursday, March 29 | 8:00AM - 11:15AM
Targeting Latency for Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 4 of 7
Jan Chemnitz, Heinrich Pette Institute, Germany
Short Talk: Excision of Proviral DNA by Tre-Recombinase in HIV-Infected Humanized Mice


Thursday, March 29 | 8:00AM - 11:15AM
Targeting Latency for Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 5 of 7
John W. Mellors, University of Pittsburgh School of Medicine, USA
Clinical Trials of Strategies to Cure HIV-1 Infection


Thursday, March 29 | 8:00AM - 11:15AM
Targeting Latency for Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 6 of 7
Sharon R. Lewin, University of Melbourne, Australia
Understanding Infection of Resting T-Cells and Maintenance of Latency: The Role of Myeloid Dendritic Cells


Thursday, March 29 | 8:00AM - 11:15AM
Targeting Latency for Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 7 of 7
Kathryn Miller-Jensen, Yale University, USA
Short Talk: Chromatin Accessibility at the HIV-1 LTR Promoter Sets a Threshold for NF-kappaB-Mediated Viral Gene Expression


Thursday, March 29 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Thursday, March 29 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Thursday, March 29 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, March 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Virus Host Interactions
Room: Sea to Sky C

Speaker 1 of 7
* Judith M. White, University of Virginia Health Sciences Center, USA

Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Virus Host Interactions
Room: Sea to Sky C

Speaker 2 of 7
Susanna Ruth Bidgood, MRC Laboratory of Molecular Biology, UK
Mechanism of Antibody-Dependent Intracellular Neutralization Mediated by TRIM21

Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Virus Host Interactions
Room: Sea to Sky C

Speaker 3 of 7
Chengyu Liang, University of Southern California, USA
Autophagic Tumor Suppressor UVRAG Controls Viral Endosomal Transport and Release

Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Virus Host Interactions
Room: Sea to Sky C

Speaker 4 of 7
Emily Happy Miller, Albert Einstein College of Medicine, USA
Host-Programmed Recognition of an Intracellular Entry Receptor by Ebola Virus

Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Virus Host Interactions
Room: Sea to Sky C

Speaker 5 of 7
Frank Neipel, Universitaet Erlangen, Germany
The Ephrin Receptor Tyrosine Kinase A2 is a Cellular Receptor for Kaposi’s Sarcoma-Associated Herpesvirus

Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Virus Host Interactions
Room: Sea to Sky C

Speaker 6 of 7
Ryan S. Noyce, Dalhousie University, Canada
Tumor Cell Marker PVRL4 (NECTIN 4) is an Epithelial Cell Receptor for Measles Virus

Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Virus Host Interactions
Room: Sea to Sky C

Speaker 7 of 7
Christopher M. Robinson, Indiana University, USA
Virus-Microbiota Interactions in the Gut: The Role of Bacterial Polysaccharides

Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Cell Biology of HIV Infection
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 1 of 9
* Thomas J. Hope, Northwestern University, USA


Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Cell Biology of HIV Infection
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 2 of 9
Lars-Anders Carlson, NIDDK, National Institutes of Health, USA
Towards an in vitro Reconstitution of HIV-1 Assembly and Release


Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Cell Biology of HIV Infection
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 3 of 9
Tonya Kueck, King's College London, UK
A Trafficking Determinant in HIV-1 VPU is Essential to Counteract Type 1 Interferon-Induced Levels of Tetherin in CD4+ T Cells


Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Cell Biology of HIV Infection
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 4 of 9
Kyeongeun Lee, NCI, National Institutes of Health, USA
CPSF6 and TNPO3 Interactions Regulate HIV-1 Infection


Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Cell Biology of HIV Infection
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 5 of 9
Quentin J. Sattentau, Sir William Dunn School of Pathology, UK
Efficient Macrophage Infection by Uptake of Dying HIV-1-Infected T Cells


Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Cell Biology of HIV Infection
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 6 of 9
Nicholas Francella, University of Pennsylvania, USA
Emergence of CD4-Independent SIV Variants during in vivo SIV Adaptation to a Lack of CD4


Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Cell Biology of HIV Infection
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 7 of 9
Anna Christina Kajaste-Rudnitski, San Raffaele Scientific Institute, Italy
Molecular Insights Into TRIM22-Mediated HIV-1 Transcriptional Repression


Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Cell Biology of HIV Infection
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 8 of 9
Felipe DiazGriffero, Einstein, USA
RING Domain Mutations Uncouple TRIM5alpha Restriction of HIV-1 from Inhibition of Reverse Transcription and Acceleration of Uncoating


Thursday, March 29 | 2:30PM - 4:30PM
Workshop 2: Cell Biology of HIV Infection
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 9 of 9
Angela M. Gronenborn, University of Pittsburgh, USA
Structures of Vpr and Vpx in DDB1-DCAF1 Complexes - Unique Surfaces for Substrate Recruitment


Thursday, March 29 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Thursday, March 29 | 5:00PM - 7:00PM
Systems Approaches to Virology
Room: Sea to Sky C

Speaker 1 of 5
* Nir Hacohen, Massachusetts General Hospital, USA

Thursday, March 29 | 5:00PM - 7:00PM
Systems Approaches to Virology
Room: Sea to Sky C

Speaker 2 of 5
Andrew Fire, Stanford University, USA
Evolution of Effector Repertoire in Response to Viral Infection

Thursday, March 29 | 5:00PM - 7:00PM
Systems Approaches to Virology
Room: Sea to Sky C

Speaker 3 of 5
Abraham L. Brass, University of Massachusetts Medical School, USA
Genetic Strategies to Investigate Host-Virus Interactions

Thursday, March 29 | 5:00PM - 7:00PM
Systems Approaches to Virology
Room: Sea to Sky C

Speaker 4 of 5
Bruce M. McManus, University of British Columbia, Canada
Host Signaling Response to Coxsackievirus B3

Thursday, March 29 | 5:00PM - 7:00PM
Systems Approaches to Virology
Room: Sea to Sky C

Speaker 5 of 5
Gilad Sivan, NIAID, National Institutes of Health, USA
Short Talk: Human Genome-Wide siRNA Screen Reveals the Importance of the Nuclear Pores for the Cytoplasmic Life Cycle of Vaccinia Virus

Thursday, March 29 | 5:00PM - 7:00PM
New Approaches to Antiviral Treatment
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 1 of 5
* Douglas D. Richman, University of California, San Diego, USA


Thursday, March 29 | 5:00PM - 7:00PM
New Approaches to Antiviral Treatment
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 2 of 5
Zeger Debyser, KU Leuven, Belgium
LEDGINs Potently Inhibit HIV Replication and Block Multiple Functions during Integration


Thursday, March 29 | 5:00PM - 7:00PM
New Approaches to Antiviral Treatment
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 3 of 5
Paula M. Cannon, University of Southern California, Keck School of Medicine, USA
Engineering Cells to Resist HIV Infection by CCR5 Knockout


Thursday, March 29 | 5:00PM - 7:00PM
New Approaches to Antiviral Treatment
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 4 of 5
Sarah E. Palmer, University of Sydney, Australia
Characterizing and Targeting Latent HIV Reservoirs


Thursday, March 29 | 5:00PM - 7:00PM
New Approaches to Antiviral Treatment
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 5 of 5
Patrick M. Younan, Fred Hutchinson Cancer Research Center, USA
Short Talk: Immune Response Promotes Recovery of Unmodified CD4+ T-Cells in the SHIV-Macaque Model after Hematopoietic Stem Cell Gene Therapy


Thursday, March 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Thursday, March 29 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky A


Friday, March 30 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A, Garibaldi B/C


Friday, March 30 | 8:00AM - 11:00AM
Immunity and Viral Evasion
Room: Sea to Sky C

Speaker 1 of 5
* Michael Farzan, The Scripps Research Institute, USA

Friday, March 30 | 8:00AM - 11:00AM
Immunity and Viral Evasion
Room: Sea to Sky C

Speaker 2 of 5
Dan R. Littman, HHMI/New York University School of Medicine, USA
Dendritic Cell Sensing

Friday, March 30 | 8:00AM - 11:00AM
Immunity and Viral Evasion
Room: Sea to Sky C

Speaker 3 of 5
Jonathan C. Kagan, Boston Children's Hospital, USA
Peroxisomes, MAVS and Innate Immunity

Friday, March 30 | 8:00AM - 11:00AM
Immunity and Viral Evasion
Room: Sea to Sky C

Speaker 4 of 5
Diane E. Griffin, Johns Hopkins Bloomberg School of Public Health, USA
Measles: Determinants of Virus Clearance and Protective Immunity

Friday, March 30 | 8:00AM - 11:00AM
Immunity and Viral Evasion
Room: Sea to Sky C

Speaker 5 of 5
Nir Hacohen, Massachusetts General Hospital, USA
Innate Responses to Influenza A Virus

Friday, March 30 | 8:00AM - 11:00AM
Models for Therapy and Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 1 of 6
* Melanie M. Ott, Gladstone Institutes, USA


Friday, March 30 | 8:00AM - 11:00AM
Models for Therapy and Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 2 of 6
J. Victor Garcia-Martinez, University of North Carolina at Chapel Hill, USA
The Humanized BLT Mouse Model


Friday, March 30 | 8:00AM - 11:00AM
Models for Therapy and Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 3 of 6
Zandrea Ambrose, University of Pittsburgh, USA
Using Macaque Models to Study HIV Persistence and Eradication Strategies


Friday, March 30 | 8:00AM - 11:00AM
Models for Therapy and Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 4 of 6
Binhua Ling, Tulane National Primate Research Center, USA
Short Talk: The Effect of Antiretroviral Therapy on SIV Gut Mucosal Reservoirs in Chinese Rhesus macaques of SIV Infection – New Non-Human Primate Model for Identification and Eradication of HIV Tissue Reservoirs


Friday, March 30 | 8:00AM - 11:00AM
Models for Therapy and Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 5 of 6
Kathleen L. Collins, University of Michigan Medical Center, USA
HIV-1 Infection of Hematopoietic Progenitor Cells


Friday, March 30 | 8:00AM - 11:00AM
Models for Therapy and Eradication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 6 of 6
Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Short Talk: Strategies for Evaluation of Residual Virus and Viral Eradication Approaches in Antiretroviral Drug Suppressed, SIV-Infected Rhesus macaques


Friday, March 30 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Friday, March 30 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Friday, March 30 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Friday, March 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Friday, March 30 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Friday, March 30 | 5:00PM - 7:00PM
Viral Assembly and Replication
Room: Sea to Sky C

Speaker 1 of 6
* Andrew Mehle, University of Wisconsin, Madison, USA

Friday, March 30 | 5:00PM - 7:00PM
Viral Assembly and Replication
Room: Sea to Sky C

Speaker 2 of 6
Sean P. Whelan, Harvard Medical School, USA
Control of Polymerase Activity during Replication and Assembly of Negative-Sense RNA Viruses

Friday, March 30 | 5:00PM - 7:00PM
Viral Assembly and Replication
Room: Sea to Sky C

Speaker 3 of 6
Barbara Müller, Heidelberg University Hospital, Germany
HIV Assembly and Maturation

Friday, March 30 | 5:00PM - 7:00PM
Viral Assembly and Replication
Room: Sea to Sky C

Speaker 4 of 6
Emily Bruce, University of Cambridge, UK
Short Talk: Rab11 and its Effector Myosin Vb are Involved in Late Stages of Influenza Virus Assembly and Budding

Friday, March 30 | 5:00PM - 7:00PM
Viral Assembly and Replication
Room: Sea to Sky C

Speaker 5 of 6
Mickey J. Pentecost, David Geffen School of Medicine at University of California, Los Angeles, USA
Short Talk: SUMO and Ubiquitin Modifications in the Subnuclear Trafficking and Function of Nipah Virus Matrix

Friday, March 30 | 5:00PM - 7:00PM
Viral Assembly and Replication
Room: Sea to Sky C

Speaker 6 of 6
Roland Schwarzer, Humboldt University, Germany
Short Talk: The Role of Lipid Rafts in Virus Assembly

Friday, March 30 | 5:00PM - 7:00PM
Host Factors and HIV Replication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 1 of 5
* Angela M. Gronenborn, University of Pittsburgh, USA


Friday, March 30 | 5:00PM - 7:00PM
Host Factors and HIV Replication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 2 of 5
Alan N. Engelman, Dana-Farber Cancer Institute, USA
HIV-Host Interactions in Nuclear Import and Integration


Friday, March 30 | 5:00PM - 7:00PM
Host Factors and HIV Replication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 3 of 5
Eric O. Freed, NCI, National Institutes of Health, USA
Host Cell Factors in Retrovirus Assembly and Release


Friday, March 30 | 5:00PM - 7:00PM
Host Factors and HIV Replication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 4 of 5
Jonathan P. Stoye, Francis Crick Institute, UK
SAMHD1 and HIV-1 Replication


Friday, March 30 | 5:00PM - 7:00PM
Host Factors and HIV Replication
This session is from HIV Pathogenesis
Room: Sea to Sky B

Speaker 5 of 5
Schuyler Van Engelenburg, NICHD, National Institutes of Health, USA
Short Talk: Characterization of HIV-1 Gag Assembly and Particle Production


Friday, March 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Friday, March 30 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A


Friday, March 30 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Saturday, March 31 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.