Web Desc
Multiple Sclerosis
Organizer(s): Trevor J. Kilpatrick, Brenda Banwell and Hartmut Wekerle
Date: January 11 - 16, 2013
Location: Big Sky Resort, Big Sky, MT, USA
Sponsored by Biogen Idec and the National Multiple Sclerosis Society
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Summary of Meeting:
Multiple sclerosis (MS) is a complex disease in which genetic, environmental and stochastic factors all play a part to induce aberrant interactions between the immune system and neural cells, ultimately transforming into progressive neurological disability. Our understanding of MS is rapidly evolving, and multiple areas of research are showing great promise of future treatment or cure. However, further progress will depend on establishing a deep understanding of the underlying disease mechanisms. With this in mind, this meeting aims to: 1) Define integrated approaches by which to study disease pathogenesis, which represents a critical barrier to progress in the field; 2) Provide an up-to-date perspective on molecular pathogenesis and how this might be used to optimize patient management; 3) Define state-of-the-art technologies by which to quantitate disease burden; 4) Discuss key elements concerning the concept of disease heterogeneity and how emergent approaches to disease stratification can optimize management strategies; and 5) Provide perspectives concerning the potential therapeutic applications of neuroprotective, regenerative and bioengineering-based strategies, and how these might complement immunotherapy. Speakers have been carefully selected on the basis that, independent of whether they are basic scientists or clinician researchers, they each have a track record in adopting a multi-disciplinary approach that has enabled the application of discoveries in one area of endeavor to seed advances in another. We anticipate that participants will gain an understanding of how a systems biology-based approach can accelerate our knowledge base of multiple sclerosis and how that knowledge base can be successfully applied to novel clinical research and development, as well as potentiated patient care.
Scholarship Deadline: September 12 2012
Discounted Abstract Deadline: September 12 2012
Abstract Deadline: October 11 2012
Discounted Registration Deadline: November 12 2012
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Biogen IdecNational Multiple Sclerosis Society
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS080288-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, January 11 | 4:00PM - 8:00PM
Arrival and Registration
Room: Lower Atrium


Saturday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Saturday, January 12 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Jefferson/Madison

Speaker 1 of 2
* Trevor J. Kilpatrick, University of Melbourne, Australia

Saturday, January 12 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Jefferson/Madison

Speaker 2 of 2
Lawrence Steinman, Stanford University, USA
When Bad is Good: Amyloid Molecules as Guardians of the Brain. An Unexpected Role of Amloidogenic Molecules in Multiple Sclerosis and Ischemic Diseases: aB Crystalline, Amyloid-beta, tau, Prion Protein and other Amyloids

Saturday, January 12 | 9:00AM - 11:15AM
Nature and Nurture: Insights Beyond GWAS and Epidemiological
Studies

Room: Jefferson/Madison

Speaker 1 of 4
Patrizia Casaccia, Advanced Science Research Center, USA
Genome-Wide Study of DNA Methylation Reveals Epigenetic Alterations in Normal Appearing White Matter of MS Brains

Saturday, January 12 | 9:00AM - 11:15AM
Nature and Nurture: Insights Beyond GWAS and Epidemiological
Studies

Room: Jefferson/Madison

Speaker 2 of 4
Justin P. Rubio, GlaxoSmithKline R&D, UK
Realizing the Promise of Pharmacogenomics

Saturday, January 12 | 9:00AM - 11:15AM
Nature and Nurture: Insights Beyond GWAS and Epidemiological
Studies

Room: Jefferson/Madison

Speaker 3 of 4
Tomas Olsson, Karolinska Institutet, Sweden
Genes and Lifestyle/Environmental Factors in Multiple Sclerosis

Saturday, January 12 | 9:00AM - 11:15AM
Nature and Nurture: Insights Beyond GWAS and Epidemiological
Studies

Room: Jefferson/Madison

Speaker 4 of 4
Judith Field, University of Melbourne, Australia
Short Talk: Gene Expression in Immune Cell Subsets: A Risk Gene Study for Multiple Sclerosis

Saturday, January 12 | 9:40AM - 10:00AM
Coffee Break
Room: Lower Atrium


Saturday, January 12 | 11:15AM - 1:00PM
Poster Setup
Room: Gallatin


Saturday, January 12 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Saturday, January 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Saturday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Saturday, January 12 | 5:00PM - 7:15PM
Cellular and Molecular Profiling: The Road to an Integrated
Approach

Room: Jefferson/Madison

Speaker 1 of 5
* Hartmut Wekerle, Max Planck Institute, Germany
From Gut to Brain: The Complex Build-Up of Experimental Autoimmune Encephalomyelitis

Saturday, January 12 | 5:00PM - 7:15PM
Cellular and Molecular Profiling: The Road to an Integrated
Approach

Room: Jefferson/Madison

Speaker 2 of 5
William H. Robinson, Stanford University School of Medicine, USA
From Tissue to Proteomics and Lipidomics

Saturday, January 12 | 5:00PM - 7:15PM
Cellular and Molecular Profiling: The Road to an Integrated
Approach

Room: Jefferson/Madison

Speaker 3 of 5
Ronald N. Germain, NIAID, National Institutes of Health, USA
Using Highly Multiplexed Data Collection and Computational Biology to Probe the Human Immune System

Saturday, January 12 | 5:00PM - 7:15PM
Cellular and Molecular Profiling: The Road to an Integrated
Approach

Room: Jefferson/Madison

Speaker 4 of 5
Simone C. Wuest, NINDS, National Institutes of Health, USA
Short Talk: Investigation of Cellular Intrathecal and Peripheral Immune Responses in Patients with Multiple Sclerosis

Saturday, January 12 | 5:00PM - 7:15PM
Cellular and Molecular Profiling: The Road to an Integrated
Approach

Room: Jefferson/Madison

Speaker 5 of 5
Peter Kosa, NIAID, National Institutes of Health, USA
Short Talk: Exosomes – A Potential Source of Biomarkers in Multiple Sclerosis

Saturday, January 12 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Gallatin


Saturday, January 12 | 7:30PM - 10:00PM
Poster Session 1
Room: Gallatin


Sunday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Sunday, January 13 | 8:00AM - 11:00AM
Paraclinical Measures of Structural and Functional Change
Room: Jefferson/Madison

Speaker 1 of 7
* Catherine Lubetzki, INSERM and University Pierre et Marie Curie (UPMC), France

Sunday, January 13 | 8:00AM - 11:00AM
Paraclinical Measures of Structural and Functional Change
Room: Jefferson/Madison

Speaker 2 of 7
Elliot M. Frohman, University of Texas Southwestern Medical Center, USA
Eye-ing a Window of Neuroprotection in the Visual System for MS

Sunday, January 13 | 8:00AM - 11:00AM
Paraclinical Measures of Structural and Functional Change
Room: Jefferson/Madison

Speaker 3 of 7
John C. Gore, Vanderbilt University, USA
Recent Developments in MRI

Sunday, January 13 | 8:00AM - 11:00AM
Paraclinical Measures of Structural and Functional Change
Room: Jefferson/Madison

Speaker 4 of 7
Adrienne N. Dula, Vanderbilt University, USA
Short Talk: Molecular MRI of Multiple Sclerosis Using 7 Tesla Chemical Exchange Saturation Transfer (CEST)

Sunday, January 13 | 8:00AM - 11:00AM
Paraclinical Measures of Structural and Functional Change
Room: Jefferson/Madison

Speaker 5 of 7
Paul M. Matthews, Imperial College London, UK
Short Talk: Towards Imaging Dynamics of the Innate Immune Response in Multiple Sclerosis

Sunday, January 13 | 8:00AM - 11:00AM
Paraclinical Measures of Structural and Functional Change
Room: Jefferson/Madison

Speaker 6 of 7
Frauke Zipp, Johannes-Gutenberg-Universität Mainz, Germany
Crosstalk of the Immune and Nervous Systems

Sunday, January 13 | 8:00AM - 11:00AM
Paraclinical Measures of Structural and Functional Change
Room: Jefferson/Madison

Speaker 7 of 7
Martin Kerschensteiner, Ludwig Maximilians University Munich, Germany
Harnessing the Potential of Cellular and Molecular in vivo Imaging Techniques

Sunday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Sunday, January 13 | 11:00AM - 1:00PM
Poster Setup
Room: Gallatin


Sunday, January 13 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Sunday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Sunday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Sunday, January 13 | 5:00PM - 7:00PM
Immunopathogenesis
Room: Jefferson/Madison

Speaker 1 of 5
* Lawrence Steinman, Stanford University, USA

Sunday, January 13 | 5:00PM - 7:00PM
Immunopathogenesis
Room: Jefferson/Madison

Speaker 2 of 5
Stephen M. Anderton, University of Edinburgh, UK
Immune-Mediated Autoaggression and Regulation

Sunday, January 13 | 5:00PM - 7:00PM
Immunopathogenesis
Room: Jefferson/Madison

Speaker 3 of 5
Takashi Yamamura, National Institute of Neuroscience, NCNP, Japan
Integrating Innate Immunity and Key Environmental Interactions

Sunday, January 13 | 5:00PM - 7:00PM
Immunopathogenesis
Room: Jefferson/Madison

Speaker 4 of 5
Bahareh Ajami, Stanford University School of Medicine, USA
Short Talk: Pathological Differences in Th1 and Th17 Mediated Experimental Autoimmune Encephalomyelitis (EAE)

Sunday, January 13 | 5:00PM - 7:00PM
Immunopathogenesis
Room: Jefferson/Madison

Speaker 5 of 5
Stephen D. Miller, Northwestern University Medical School, USA
Tolerance Induction Using Myeline Peptide Coupled Apoptotic Cells and Biodegradable Nanparticles for MS Therapy

Sunday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Gallatin


Sunday, January 13 | 7:30PM - 10:00PM
Poster Session 2
Room: Gallatin


Monday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Monday, January 14 | 8:00AM - 11:00AM
Clinical Controversies
Room: Jefferson/Madison

Speaker 1 of 5
Helen Tremlett, University of British Columbia, Canada
Disease Heterogeneity: Emerging Concepts in MS

Monday, January 14 | 8:00AM - 11:00AM
Clinical Controversies
Room: Jefferson/Madison

Speaker 2 of 5
Jun-ichi Kira, Kyushu University, Japan
Cutting Edges of Multiple Sclerosis and Neuromyelitis Optica

Monday, January 14 | 8:00AM - 11:00AM
Clinical Controversies
Room: Jefferson/Madison

Speaker 3 of 5
* Brenda Banwell, University of Pennsylvania, USA
Negotiating Between ADEM, CIS and MS: An Age-Specific Roadmap

Monday, January 14 | 8:00AM - 11:00AM
Clinical Controversies
Room: Jefferson/Madison

Speaker 4 of 5
Judith M. Greer, University of Queenland, Australia
Short Talk: HLA Alleles Play a Role in Determining the Disease Course and Distribution of Lesions in MS

Monday, January 14 | 8:00AM - 11:00AM
Clinical Controversies
Room: Jefferson/Madison

Speaker 5 of 5
Timothy Coetzee, National Multiple Sclerosis Society, USA
CCSVI – Lessons for Funders and the Research Community

Monday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Monday, January 14 | 11:00AM - 1:00PM
Poster Setup
Room: Gallatin


Monday, January 14 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Monday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Monday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Monday, January 14 | 5:00PM - 7:00PM
Clinical Developments
Room: Jefferson/Madison

Speaker 1 of 4
Richard K. Burt, Northwestern University, USA
Hematopoietic Stem Cell Transplantation for Multiple Sclerosis

Monday, January 14 | 5:00PM - 7:00PM
Clinical Developments
Room: Jefferson/Madison

Speaker 2 of 4
* Richard A. Rudick, Cleveland Clinic Foundation, USA
Design Issues for Clinical Trials in Progressive MS

Monday, January 14 | 5:00PM - 7:00PM
Clinical Developments
Room: Jefferson/Madison

Speaker 3 of 4
Paul M. Matthews, Imperial College London, UK
Treatment Stratification for MS: Opportunities and Challenges

Monday, January 14 | 5:00PM - 7:00PM
Clinical Developments
Room: Jefferson/Madison

Speaker 4 of 4
Zongqi Xia, University of Pittsburgh, USA
Short Talk: Leveraging Electronic Health Records for Research in Multiple Sclerosis

Monday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Gallatin


Monday, January 14 | 7:30PM - 10:00PM
Poster Session 3
Room: Gallatin


Tuesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Tuesday, January 15 | 8:00AM - 11:00AM
Neurobiology
Room: Jefferson/Madison

Speaker 1 of 6
Peter K. Stys, University of Calgary, Canada
Axon-Glial Interactions in MS and AD

Tuesday, January 15 | 8:00AM - 11:00AM
Neurobiology
Room: Jefferson/Madison

Speaker 2 of 6
* Trevor J. Kilpatrick, University of Melbourne, Australia
Targeting the Oligodendrocyte Lineage in Demyelinative Disease

Tuesday, January 15 | 8:00AM - 11:00AM
Neurobiology
Room: Jefferson/Madison

Speaker 3 of 6
Patrick Kuery, University of Duesseldorf, Germany
Short Talk: Nucleocytoplasmic Translocation of p57kip2 Promotes Oligodendroglial Differentiation

Tuesday, January 15 | 8:00AM - 11:00AM
Neurobiology
Room: Jefferson/Madison

Speaker 4 of 6
Hedwich F. Kuipers, Stanford University, USA
Short Talk: Differential Roles for the Small Heat Shock Protein Alpha B-Crystallin in Cuprizone-Induced De- and Remyelination

Tuesday, January 15 | 8:00AM - 11:00AM
Neurobiology
Room: Jefferson/Madison

Speaker 5 of 6
Catherine Lubetzki, INSERM and University Pierre et Marie Curie (UPMC), France
Remyelination in MS: The New Frontier?

Tuesday, January 15 | 8:00AM - 11:00AM
Neurobiology
Room: Jefferson/Madison

Speaker 6 of 6
Peter I. Jukkola, Ohio State University, USA
Short Talk: K+ Channel Alterations in the Progression of Experimental Autoimmune Encephalomyelitis

Tuesday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Tuesday, January 15 | 11:30AM - 4:30PM
On Own for Lunch and Recreation


Tuesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Tuesday, January 15 | 5:00PM - 7:00PM
Cellular Dynamics Underpinning Pathogenesis and Repair
Room: Jefferson/Madison

Speaker 1 of 3
* Amit Bar-Or, University of Pennsylvania, USA
Immune:Glial Interactions in MS: Implication during CNS Injury and Repair

Tuesday, January 15 | 5:00PM - 7:00PM
Cellular Dynamics Underpinning Pathogenesis and Repair
Room: Jefferson/Madison

Speaker 2 of 3
Shannon Dunn, University of Maryland, Baltimore, USA
Sex Differences in Multiple Sclerosis: Role for Male and Female Pubertal Factors

Tuesday, January 15 | 5:00PM - 7:00PM
Cellular Dynamics Underpinning Pathogenesis and Repair
Room: Jefferson/Madison

Speaker 3 of 3
Gianvito Martino, San Raffaele Scientific Institute, Italy
The Role of Neural Stem Cells in Brain Regeneration: Where we are and Where we go in Multiple Sclerosis

Tuesday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Gallatin


Tuesday, January 15 | 8:00PM - 11:00PM
Entertainment
Room: Gallatin


Tuesday, January 15 | 8:00PM - 11:00PM
Cash Bar
Room: Gallatin


Wednesday, January 16 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.