Web Desc
New Frontiers in Cardiovascular Genetics Beyond GWAS
Organizer(s): Jennifer L. Hall and Stephen S. Rich
Date: January 13 - 18, 2013
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by an educational donation provided by Amgen
Summary of Meeting:
This meeting will highlight the latest advances in the field and new approaches in genomics and genetics applied to cardiovascular disease and risk factors. Research in the areas of DNA and RNA sequencing and bioinformatics, as it relates to heart failure, sudden cardiac death and coronary artery disease, will be presented from the perspectives of academia and industry around the world. Challenges in the pursuit of translating genetic findings into diagnostic tests and therapies will be discussed by leading experts who have identified new strategies. The sessions feature state-of-the-art talks in genome biology and genome sequencing for guiding medicine decisions, clinical trial designs and tailored medical treatments. This meeting offers a rare and unique opportunity to explore the most current breakthroughs in genetics and personalized medicine from within and outside the field of cardiovascular biology.
Scholarship Deadline: September 12 2012
Discounted Abstract Deadline: September 12 2012
Abstract Deadline: October 25 2012
Discounted Registration Deadline: November 12 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Educational donation provided by Amgen
We gratefully acknowledge additional support for this conference from:
American Heart Association
American Heart Association's Council on Functional Genomics and Translational Biology
Landes Bioscience
$2,500 - $9,999
S. Karger AG - Cardiology
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
S. Karger AG - Cardiology
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL115913-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 13 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function


Sunday, January 13 | 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall


Monday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, January 14 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Mountain/Lake

Speaker 1 of 3
* Jennifer L. Hall, University of Minnesota, USA

Monday, January 14 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Mountain/Lake

Speaker 2 of 3
* Stephen S. Rich, University of Virginia, USA

Monday, January 14 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Mountain/Lake

Speaker 3 of 3
Eric D. Green, NHGRI, National Institutes of Health, USA
Entering the Era of Genomic Medicine: Research Opportunities and Challenges

Monday, January 14 | 9:00AM - 11:30AM
Breakthroughs in Sequencing and New Approaches in Applicatio
ns

Room: Mountain/Lake

Speaker 1 of 4
Leroy E. Hood, Institute for Systems Biology, USA
Systems Medicine and a Systems Approach to Diseases

Monday, January 14 | 9:00AM - 11:30AM
Breakthroughs in Sequencing and New Approaches in Applicatio
ns

Room: Mountain/Lake

Speaker 2 of 4
Deborah A. Nickerson, University of Washington, USA
The Next Steps in Sequencing

Monday, January 14 | 9:00AM - 11:30AM
Breakthroughs in Sequencing and New Approaches in Applicatio
ns

Room: Mountain/Lake

Speaker 3 of 4
Nathan Pearson, Knome, Inc., USA
Sharing-Enabled Genome Interpretation for Disease at Ingenuity

Monday, January 14 | 9:00AM - 11:30AM
Breakthroughs in Sequencing and New Approaches in Applicatio
ns

Room: Mountain/Lake

Speaker 4 of 4
David R. Bentley, Illumina Cambridge, Ltd., UK
Genomes in Medicine

Monday, January 14 | 9:40AM - 10:00AM
Coffee Break
Room: Pre Function


Monday, January 14 | 11:30AM - 1:00PM
Poster Setup
Room: Bay


Monday, January 14 | 11:30AM - 4:30PM
On Own for Lunch and Recreation


Monday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, January 14 | 5:00PM - 6:15PM
Discovering Genes, Networks and Function
Room: Mountain/Lake

Speaker 1 of 4
* Emelia J. Benjamin, Boston University, USA

Monday, January 14 | 5:00PM - 6:15PM
Discovering Genes, Networks and Function
Room: Mountain/Lake

Speaker 2 of 4
Bruce D. Gelb, Mount Sinai Medical Center, USA
Genetic Discovery for Congenital Heart Disease

Monday, January 14 | 5:00PM - 6:15PM
Discovering Genes, Networks and Function
Room: Mountain/Lake

Speaker 3 of 4
Richard Bonneau, New York University, USA
Learning Dynamic Genome-Scale Models of Hematopoietic Stem Cell Differentiation and Function

Monday, January 14 | 5:00PM - 6:15PM
Discovering Genes, Networks and Function
Room: Mountain/Lake

Speaker 4 of 4
Michael J. Flister, AbbVie, Inc., USA
Short Talk: Role of SH2B3 in Genetic Susceptibility to Heart Failure

Monday, January 14 | 6:15PM - 7:00PM
RoundTable Discussion (NIH)
Room: Mountain/Lake


Monday, January 14 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, January 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay


Monday, January 14 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Tuesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, January 15 | 8:00AM - 9:00AM
Keynote Address
Room: Mountain/Lake

Speaker 1 of 1
Gary H. Gibbons, NHLBI, National Institutes of Health, USA
Opportunities in Genomic Science and Genomic Medicine at the National Heart, Lung, and Blood Institute (NHLBI): From Discovery Science to Clinical and Public Health Impact

Tuesday, January 15 | 9:00AM - 11:30AM
Genetics of Coronary Artery Disease
Room: Mountain/Lake

Speaker 1 of 4
Daniel J. Rader, University of Pennsylvania, USA
Novel Biological Pathways and Therapeutic Targets in Atherosclerosis Revealed through Human Genetics

Tuesday, January 15 | 9:00AM - 11:30AM
Genetics of Coronary Artery Disease
Room: Mountain/Lake

Speaker 2 of 4
Thomas Quertermous, Stanford University School of Medicine, USA
Mechanisms Underlying the GWAS Coronary Heart Disease loci

Tuesday, January 15 | 9:00AM - 11:30AM
Genetics of Coronary Artery Disease
Room: Mountain/Lake

Speaker 3 of 4
Kelly A. Frazer, University of California San Diego School of Medicine, USA
Identifying and Characterizing Risk Loci for Coronary Artery Disease

Tuesday, January 15 | 9:00AM - 11:30AM
Genetics of Coronary Artery Disease
Room: Mountain/Lake

Speaker 4 of 4
* Geoffrey S. Ginsburg, Duke University, USA
Advances in Genome Based Cardiovascular Biomarkers

Tuesday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, January 15 | 11:30AM - 4:30PM
On Own for Lunch and Recreation


Tuesday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, January 15 | 5:00PM - 7:00PM
Structural Variation
Room: Mountain/Lake

Speaker 1 of 3
* Stephen S. Rich, University of Virginia, USA
Structural Variants and Risk in Human Disease

Tuesday, January 15 | 5:00PM - 7:00PM
Structural Variation
Room: Mountain/Lake

Speaker 2 of 3
Marcelo Nobrega, University of Chicago, USA
Regulatory Networks in Heart Development and Heart Disease

Tuesday, January 15 | 5:00PM - 7:00PM
Structural Variation
Room: Mountain/Lake

Speaker 3 of 3
Evan E. Eichler, HHMI/University of Washington, USA
Human Genome Structural Variation and Disease

Tuesday, January 15 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, January 15 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Wednesday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, January 16 | 8:00AM - 8:40AM
State of the Art in Heart Failure (Bench to Bedside)
Room: Mountain/Lake

Speaker 1 of 1
* Jennifer L. Hall, University of Minnesota, USA
Heart Failure: Bench to Bedside

Wednesday, January 16 | 8:40AM - 11:00AM
State of the Art in Genetics
Room: Mountain/Lake

Speaker 1 of 5
Christopher J. O'Donnell, NHLBI, National Institutes of Health, USA
Translating Genomic Discoveries in Populations towards Understanding, Treating and Preventing Atherosclerotic Cardiovascular Disease

Wednesday, January 16 | 8:40AM - 11:00AM
State of the Art in Genetics
Room: Mountain/Lake

Speaker 2 of 5
Gerald W. Dorn, II, Washington University School of Medicine, USA
MicroRNAs, Mutations, and the Butterfly Effect

Wednesday, January 16 | 8:40AM - 11:00AM
State of the Art in Genetics
Room: Mountain/Lake

Speaker 3 of 5
Muredach P. Reilly, Columbia University, USA
Transcriptomics of Evoked Inflammation

Wednesday, January 16 | 8:40AM - 11:00AM
State of the Art in Genetics
Room: Mountain/Lake

Speaker 4 of 5
Bijal Vyas, Sir Ganga Ram Hospital, India
Short Talk: Molecular Genetic Studies in Families with Life Threatening Cardiac Arrhythmias

Wednesday, January 16 | 8:40AM - 11:00AM
State of the Art in Genetics
Room: Mountain/Lake

Speaker 5 of 5
Daniel Steven Herman, Harvard Medical School, USA
Short Talk: Truncations of the Sarcomere Protein Titin in the General Population

Wednesday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, January 16 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Wednesday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Wednesday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, January 16 | 5:00PM - 7:00PM
Current Updates on DNA, microRNA, and Model Organisms in Hea
rt Disease

Room: Mountain/Lake

Speaker 1 of 4
* Emelia J. Benjamin, Boston University, USA
The Genetics of Atrial Fibrillation

Wednesday, January 16 | 5:00PM - 7:00PM
Current Updates on DNA, microRNA, and Model Organisms in Hea
rt Disease

Room: Mountain/Lake

Speaker 2 of 4
Calum A. MacRae, Brigham & Women's Hospital, USA
High-Throughput in vivo Exploration of Disease Networks in Zebrafish

Wednesday, January 16 | 5:00PM - 7:00PM
Current Updates on DNA, microRNA, and Model Organisms in Hea
rt Disease

Room: Mountain/Lake

Speaker 3 of 4
Manuel Mayr, King's College, University of London, UK
MicroRNAs within the Continuum of Postgenomics Biomarker Discovery

Wednesday, January 16 | 5:00PM - 7:00PM
Current Updates on DNA, microRNA, and Model Organisms in Hea
rt Disease

Room: Mountain/Lake

Speaker 4 of 4
Jose R. Perez, C4 Therapeutics, Inc., USA
Short Talk: TRIB1 Inducers and LDL Metabolism

Wednesday, January 16 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Wednesday, January 16 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Thursday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, January 17 | 8:00AM - 11:00AM
Breakthroughs in Genomics and Personalized Medicine
Room: Mountain/Lake

Speaker 1 of 6
* Howard J. Jacob, HudsonAlpha Institute for Bioltechnology, USA
Whole Genome Sequencing: Just Another Clinical Lab Diagnostic?

Thursday, January 17 | 8:00AM - 11:00AM
Breakthroughs in Genomics and Personalized Medicine
Room: Mountain/Lake

Speaker 2 of 6
Nola Masterson, Science Futures, Inc., USA
and

Thursday, January 17 | 8:00AM - 11:00AM
Breakthroughs in Genomics and Personalized Medicine
Room: Mountain/Lake

Speaker 3 of 6
Martin G. Reese, Fabric Genomics, USA
What is Next? Interpreting Genomes at Scale for Clinical Relevance

Thursday, January 17 | 8:00AM - 11:00AM
Breakthroughs in Genomics and Personalized Medicine
Room: Mountain/Lake

Speaker 4 of 6
Michael R. Bristow, University of Colorado Anschutz Medical Campus, USA
Pharmacogenetic Targeting of Cardiovascular Drugs

Thursday, January 17 | 8:00AM - 11:00AM
Breakthroughs in Genomics and Personalized Medicine
Room: Mountain/Lake

Speaker 5 of 6
Euan A. Ashley, Stanford University, USA
Short Talk: Systems Approach Identifies the Orphan Receptor Tyrosine Kinase Ros1 as a Mediator of Human Vascular Remodeling

Thursday, January 17 | 8:00AM - 11:00AM
Breakthroughs in Genomics and Personalized Medicine
Room: Mountain/Lake

Speaker 6 of 6
Janina M. Jeff, Mount Sinai School of Medicine, USA
Short Talk: Fine Mapping the SCN10A Gene Identifies Novel Associations with PR Interval in African Americans

Thursday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Thursday, January 17 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Thursday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Thursday, January 17 | 5:00PM - 7:00PM
Difficulties in Going from Genotype to Phenotype
Room: Mountain/Lake

Speaker 1 of 3
* Eric A. Boerwinkle, University of Texas, USA
Genotype to Phenotype with Hypertension: The Challenges

Thursday, January 17 | 5:00PM - 7:00PM
Difficulties in Going from Genotype to Phenotype
Room: Mountain/Lake

Speaker 2 of 3
Aravinda Chakravarti, Johns Hopkins University School of Medicine, USA
From Genome to Function

Thursday, January 17 | 5:00PM - 7:00PM
Difficulties in Going from Genotype to Phenotype
Room: Mountain/Lake

Speaker 3 of 3
Nicole Soranzo, Wellcome Trust Sanger Institute, UK
Next Generation Association Studies

Thursday, January 17 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Thursday, January 17 | 7:00PM - 8:00PM
Social Hour
Room: Granhall


Thursday, January 17 | 8:00PM - 11:00PM
Entertainment
Room: Granhall


Thursday, January 17 | 8:00PM - 11:00PM
Cash Bar
Room: Granhall


Friday, January 18 | 10:25AM - 10:25AM
Departure


*Session Chair.