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Web Desc
New Frontiers in Cardiovascular Genetics Beyond GWAS Organizer(s): Jennifer L. Hall and Stephen S. Rich Date: January 13 - 18, 2013 Location: Granlibakken Tahoe, Tahoe City, CA, USA Supported by an educational donation provided by Amgen Summary of Meeting: This meeting will highlight the latest advances in the field and new approaches in genomics and genetics applied to cardiovascular disease and risk factors. Research in the areas of DNA and RNA sequencing and bioinformatics, as it relates to heart failure, sudden cardiac death and coronary artery disease, will be presented from the perspectives of academia and industry around the world. Challenges in the pursuit of translating genetic findings into diagnostic tests and therapies will be discussed by leading experts who have identified new strategies. The sessions feature state-of-the-art talks in genome biology and genome sequencing for guiding medicine decisions, clinical trial designs and tailored medical treatments. This meeting offers a rare and unique opportunity to explore the most current breakthroughs in genetics and personalized medicine from within and outside the field of cardiovascular biology. Scholarship Deadline: September 12 2012 Discounted Abstract Deadline: September 12 2012 Abstract Deadline: October 25 2012 Discounted Registration Deadline: November 12 2012 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: American Heart Association's Council on Functional Genomics and Translational Biology $2,500 - $9,999 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Heart, Lung, and Blood Institute (NHLBI) Grant No. 1R13HL115913-01 The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

New Frontiers in Cardiovascular Genetics Beyond GWAS

Organizer(s): Jennifer L. Hall and Stephen S. Rich

Date: January 13 - 18, 2013
Location: Granlibakken Tahoe, Tahoe City, CA, USA

Supported by an educational donation provided by Amgen

Summary of Meeting:

This meeting will highlight the latest advances in the field and new approaches in genomics and genetics applied to cardiovascular disease and risk factors. Research in the areas of DNA and RNA sequencing and bioinformatics, as it relates to heart failure, sudden cardiac death and coronary artery disease, will be presented from the perspectives of academia and industry around the world. Challenges in the pursuit of translating genetic findings into diagnostic tests and therapies will be discussed by leading experts who have identified new strategies. The sessions feature state-of-the-art talks in genome biology and genome sequencing for guiding medicine decisions, clinical trial designs and tailored medical treatments. This meeting offers a rare and unique opportunity to explore the most current breakthroughs in genetics and personalized medicine from within and outside the field of cardiovascular biology.

Scholarship Deadline: September 12 2012

Discounted Abstract Deadline: September 12 2012

Abstract Deadline: October 25 2012

Discounted Registration Deadline: November 12 2012

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support for this conference from:

American Heart Association's Council on Functional Genomics and Translational Biology

$2,500 - $9,999

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL115913-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, January 13 \| 4:00PM - 8:00PM Arrival and Registration Room: Pre Function
Sunday, January 13 \| 6:00PM - 8:00PM Light Meal - Provided by Granlibakken Room: Granhall
Monday, January 14 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Monday, January 14 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Mountain/Lake Speaker 1 of 3 * Jennifer L. Hall, University of Minnesota, USA
Monday, January 14 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Mountain/Lake Speaker 2 of 3 * Stephen S. Rich, University of Virginia, USA
Monday, January 14 \| 8:00AM - 9:00AM Welcome and Keynote Address Room: Mountain/Lake Speaker 3 of 3 Eric D. Green, NHGRI, National Institutes of Health, USA Entering the Era of Genomic Medicine: Research Opportunities and Challenges
Monday, January 14 \| 9:00AM - 11:30AM Breakthroughs in Sequencing and New Approaches in Applicatio ns Room: Mountain/Lake Speaker 1 of 4 Leroy E. Hood, Institute for Systems Biology, USA Systems Medicine and a Systems Approach to Diseases
Monday, January 14 \| 9:00AM - 11:30AM Breakthroughs in Sequencing and New Approaches in Applicatio ns Room: Mountain/Lake Speaker 2 of 4 Deborah A. Nickerson, University of Washington, USA The Next Steps in Sequencing
Monday, January 14 \| 9:00AM - 11:30AM Breakthroughs in Sequencing and New Approaches in Applicatio ns Room: Mountain/Lake Speaker 3 of 4 Nathan Pearson, Knome, Inc., USA Sharing-Enabled Genome Interpretation for Disease at Ingenuity
Monday, January 14 \| 9:00AM - 11:30AM Breakthroughs in Sequencing and New Approaches in Applicatio ns Room: Mountain/Lake Speaker 4 of 4 David R. Bentley, Illumina Cambridge, Ltd., UK Genomes in Medicine
Monday, January 14 \| 9:40AM - 10:00AM Coffee Break Room: Pre Function
Monday, January 14 \| 11:30AM - 1:00PM Poster Setup Room: Bay
Monday, January 14 \| 11:30AM - 4:30PM On Own for Lunch and Recreation
Monday, January 14 \| 1:00PM - 10:00PM Poster Viewing Room: Bay
Monday, January 14 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Monday, January 14 \| 5:00PM - 6:15PM Discovering Genes, Networks and Function Room: Mountain/Lake Speaker 1 of 4 * Emelia J. Benjamin, Boston University, USA
Monday, January 14 \| 5:00PM - 6:15PM Discovering Genes, Networks and Function Room: Mountain/Lake Speaker 2 of 4 Bruce D. Gelb, Mount Sinai Medical Center, USA Genetic Discovery for Congenital Heart Disease
Monday, January 14 \| 5:00PM - 6:15PM Discovering Genes, Networks and Function Room: Mountain/Lake Speaker 3 of 4 Richard Bonneau, New York University, USA Learning Dynamic Genome-Scale Models of Hematopoietic Stem Cell Differentiation and Function
Monday, January 14 \| 5:00PM - 6:15PM Discovering Genes, Networks and Function Room: Mountain/Lake Speaker 4 of 4 Michael J. Flister, AbbVie, Inc., USA Short Talk: Role of SH2B3 in Genetic Susceptibility to Heart Failure
Monday, January 14 \| 6:15PM - 7:00PM RoundTable Discussion (NIH) Room: Mountain/Lake
Monday, January 14 \| 7:00PM - 8:00PM Dinner Room: Granhall
Monday, January 14 \| 7:30PM - 10:00PM Poster Session 1 Room: Bay
Monday, January 14 \| 8:00PM - 9:00PM Social Hour Room: Bay
Tuesday, January 15 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Tuesday, January 15 \| 8:00AM - 9:00AM Keynote Address Room: Mountain/Lake Speaker 1 of 1 Gary H. Gibbons, NHLBI, National Institutes of Health, USA Opportunities in Genomic Science and Genomic Medicine at the National Heart, Lung, and Blood Institute (NHLBI): From Discovery Science to Clinical and Public Health Impact
Tuesday, January 15 \| 9:00AM - 11:30AM Genetics of Coronary Artery Disease Room: Mountain/Lake Speaker 1 of 4 Daniel J. Rader, University of Pennsylvania, USA Novel Biological Pathways and Therapeutic Targets in Atherosclerosis Revealed through Human Genetics
Tuesday, January 15 \| 9:00AM - 11:30AM Genetics of Coronary Artery Disease Room: Mountain/Lake Speaker 2 of 4 Thomas Quertermous, Stanford University School of Medicine, USA Mechanisms Underlying the GWAS Coronary Heart Disease loci
Tuesday, January 15 \| 9:00AM - 11:30AM Genetics of Coronary Artery Disease Room: Mountain/Lake Speaker 3 of 4 Kelly A. Frazer, University of California San Diego School of Medicine, USA Identifying and Characterizing Risk Loci for Coronary Artery Disease
Tuesday, January 15 \| 9:00AM - 11:30AM Genetics of Coronary Artery Disease Room: Mountain/Lake Speaker 4 of 4 * Geoffrey S. Ginsburg, Duke University, USA Advances in Genome Based Cardiovascular Biomarkers
Tuesday, January 15 \| 9:20AM - 9:40AM Coffee Break Room: Pre Function
Tuesday, January 15 \| 11:30AM - 4:30PM On Own for Lunch and Recreation
Tuesday, January 15 \| 1:00PM - 10:00PM Poster Viewing Room: Bay
Tuesday, January 15 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Tuesday, January 15 \| 5:00PM - 7:00PM Structural Variation Room: Mountain/Lake Speaker 1 of 3 * Stephen S. Rich, University of Virginia, USA Structural Variants and Risk in Human Disease
Tuesday, January 15 \| 5:00PM - 7:00PM Structural Variation Room: Mountain/Lake Speaker 2 of 3 Marcelo Nobrega, University of Chicago, USA Regulatory Networks in Heart Development and Heart Disease
Tuesday, January 15 \| 5:00PM - 7:00PM Structural Variation Room: Mountain/Lake Speaker 3 of 3 Evan E. Eichler, HHMI/University of Washington, USA Human Genome Structural Variation and Disease
Tuesday, January 15 \| 7:00PM - 8:00PM Dinner Room: Granhall
Tuesday, January 15 \| 8:00PM - 9:00PM Social Hour Room: Bay
Wednesday, January 16 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Wednesday, January 16 \| 8:00AM - 8:40AM State of the Art in Heart Failure (Bench to Bedside) Room: Mountain/Lake Speaker 1 of 1 * Jennifer L. Hall, University of Minnesota, USA Heart Failure: Bench to Bedside
Wednesday, January 16 \| 8:40AM - 11:00AM State of the Art in Genetics Room: Mountain/Lake Speaker 1 of 5 Christopher J. O'Donnell, NHLBI, National Institutes of Health, USA Translating Genomic Discoveries in Populations towards Understanding, Treating and Preventing Atherosclerotic Cardiovascular Disease
Wednesday, January 16 \| 8:40AM - 11:00AM State of the Art in Genetics Room: Mountain/Lake Speaker 2 of 5 Gerald W. Dorn, II, Washington University School of Medicine, USA MicroRNAs, Mutations, and the Butterfly Effect
Wednesday, January 16 \| 8:40AM - 11:00AM State of the Art in Genetics Room: Mountain/Lake Speaker 3 of 5 Muredach P. Reilly, Columbia University, USA Transcriptomics of Evoked Inflammation
Wednesday, January 16 \| 8:40AM - 11:00AM State of the Art in Genetics Room: Mountain/Lake Speaker 4 of 5 Bijal Vyas, Sir Ganga Ram Hospital, India Short Talk: Molecular Genetic Studies in Families with Life Threatening Cardiac Arrhythmias
Wednesday, January 16 \| 8:40AM - 11:00AM State of the Art in Genetics Room: Mountain/Lake Speaker 5 of 5 Daniel Steven Herman, Harvard Medical School, USA Short Talk: Truncations of the Sarcomere Protein Titin in the General Population
Wednesday, January 16 \| 9:20AM - 9:40AM Coffee Break Room: Pre Function
Wednesday, January 16 \| 11:00AM - 4:30PM On Own for Lunch and Recreation
Wednesday, January 16 \| 1:00PM - 10:00PM Poster Viewing Room: Bay
Wednesday, January 16 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Wednesday, January 16 \| 5:00PM - 7:00PM Current Updates on DNA, microRNA, and Model Organisms in Hea rt Disease Room: Mountain/Lake Speaker 1 of 4 * Emelia J. Benjamin, Boston University, USA The Genetics of Atrial Fibrillation
Wednesday, January 16 \| 5:00PM - 7:00PM Current Updates on DNA, microRNA, and Model Organisms in Hea rt Disease Room: Mountain/Lake Speaker 2 of 4 Calum A. MacRae, Brigham & Women's Hospital, USA High-Throughput in vivo Exploration of Disease Networks in Zebrafish
Wednesday, January 16 \| 5:00PM - 7:00PM Current Updates on DNA, microRNA, and Model Organisms in Hea rt Disease Room: Mountain/Lake Speaker 3 of 4 Manuel Mayr, King's College, University of London, UK MicroRNAs within the Continuum of Postgenomics Biomarker Discovery
Wednesday, January 16 \| 5:00PM - 7:00PM Current Updates on DNA, microRNA, and Model Organisms in Hea rt Disease Room: Mountain/Lake Speaker 4 of 4 Jose R. Perez, C4 Therapeutics, Inc., USA Short Talk: TRIB1 Inducers and LDL Metabolism
Wednesday, January 16 \| 7:00PM - 8:00PM Dinner Room: Granhall
Wednesday, January 16 \| 8:00PM - 9:00PM Social Hour Room: Bay
Thursday, January 17 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Thursday, January 17 \| 8:00AM - 11:00AM Breakthroughs in Genomics and Personalized Medicine Room: Mountain/Lake Speaker 1 of 6 * Howard J. Jacob, HudsonAlpha Institute for Bioltechnology, USA Whole Genome Sequencing: Just Another Clinical Lab Diagnostic?
Thursday, January 17 \| 8:00AM - 11:00AM Breakthroughs in Genomics and Personalized Medicine Room: Mountain/Lake Speaker 2 of 6 Nola Masterson, Science Futures, Inc., USA and
Thursday, January 17 \| 8:00AM - 11:00AM Breakthroughs in Genomics and Personalized Medicine Room: Mountain/Lake Speaker 3 of 6 Martin G. Reese, Fabric Genomics, USA What is Next? Interpreting Genomes at Scale for Clinical Relevance
Thursday, January 17 \| 8:00AM - 11:00AM Breakthroughs in Genomics and Personalized Medicine Room: Mountain/Lake Speaker 4 of 6 Michael R. Bristow, University of Colorado Anschutz Medical Campus, USA Pharmacogenetic Targeting of Cardiovascular Drugs
Thursday, January 17 \| 8:00AM - 11:00AM Breakthroughs in Genomics and Personalized Medicine Room: Mountain/Lake Speaker 5 of 6 Euan A. Ashley, Stanford University, USA Short Talk: Systems Approach Identifies the Orphan Receptor Tyrosine Kinase Ros1 as a Mediator of Human Vascular Remodeling
Thursday, January 17 \| 8:00AM - 11:00AM Breakthroughs in Genomics and Personalized Medicine Room: Mountain/Lake Speaker 6 of 6 Janina M. Jeff, Mount Sinai School of Medicine, USA Short Talk: Fine Mapping the SCN10A Gene Identifies Novel Associations with PR Interval in African Americans
Thursday, January 17 \| 9:20AM - 9:40AM Coffee Break Room: Pre Function
Thursday, January 17 \| 11:00AM - 4:30PM On Own for Lunch and Recreation
Thursday, January 17 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Thursday, January 17 \| 5:00PM - 7:00PM Difficulties in Going from Genotype to Phenotype Room: Mountain/Lake Speaker 1 of 3 * Eric A. Boerwinkle, University of Texas, USA Genotype to Phenotype with Hypertension: The Challenges
Thursday, January 17 \| 5:00PM - 7:00PM Difficulties in Going from Genotype to Phenotype Room: Mountain/Lake Speaker 2 of 3 Aravinda Chakravarti, Johns Hopkins University School of Medicine, USA From Genome to Function
Thursday, January 17 \| 5:00PM - 7:00PM Difficulties in Going from Genotype to Phenotype Room: Mountain/Lake Speaker 3 of 3 Nicole Soranzo, Wellcome Trust Sanger Institute, UK Next Generation Association Studies
Thursday, January 17 \| 7:00PM - 8:00PM Dinner Room: Granhall
Thursday, January 17 \| 7:00PM - 8:00PM Social Hour Room: Granhall
Thursday, January 17 \| 8:00PM - 11:00PM Entertainment Room: Granhall
Thursday, January 17 \| 8:00PM - 11:00PM Cash Bar Room: Granhall
Friday, January 18 \| 10:25AM - 10:25AM Departure *Session Chair.