Web Desc
Frontiers of NMR in Biology
Organizer(s): Gerhard Wagner, Angela M. Gronenborn and Marc Baldus
Date: January 13 - 18, 2013
Location: Snowbird Resort, Snowbird, UT, USA
Supported by the Directors' Fund
Summary of Meeting:
Nuclear magnetic resonance (NMR) spectroscopy has become an important technology in molecular biology and is widely used for elucidating biological mechanisms. It can provide structural information similar and complementary to X-ray crystallography, electron microscopy, mass spectroscopy and small-angle scattering methods. However, NMR can also provide unique insights not obtainable otherwise, such as ones involving weak interactions, enzyme reactions or dynamic states. Thus, the focus of the field is expanding from structure determination to macromolecular interactions, post-translational modifications, functional studies and drug discovery. Unexpected new technologies are constantly emerging suitable to provide new biological insights. Thus, this meeting will include sessions on new enabling technologies and applications to large and challenging systems. Topics will also include membrane protein structures, protein/nucleotide complexes and systems of high biological significance. The symposium will also include presentations on structure-derived function, post-translational modifications studied in whole cells or cell extracts, and drug discovery. The overall goal of the meeting will be to examine recent technological developments and to demonstrate state-of-the-art applications that yield new understanding of biological mechanisms.
Scholarship Deadline: September 13 2012
Discounted Abstract Deadline: September 13 2012
Abstract Deadline: October 15 2012
Discounted Registration Deadline: November 13 2012
We gratefully acknowledge additional support for this conference from:
Agilent TechnologiesBruker BioSpin Corporation
Cambridge Isotope Laboratories
ISOTEC, a member of the Sigma-Aldrich GroupNew Era Enterprises, Inc.NMR-Bio
Suraj Manrao Student Travel Fund
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck & Co., Inc.


Suraj Manrao Student Travel Fund
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 13 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Monday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, January 14 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Ballroom 2-3

Speaker 1 of 2
* Gerhard Wagner, Harvard Medical School, USA

Monday, January 14 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Ballroom 2-3

Speaker 2 of 2
Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
NMR Methods for Large RNAs: Structure of the HIV-1 5'-Leader

Monday, January 14 | 9:00AM - 12:15PM
New Methods in Solid State NMR
Room: Ballroom 2-3

Speaker 1 of 7
* Marc Baldus, Utrecht University, Netherlands

Monday, January 14 | 9:00AM - 12:15PM
New Methods in Solid State NMR
Room: Ballroom 2-3

Speaker 2 of 7
Beat H. Meier, ETH Zürich, Switzerland
Amyloid Structures by Solid State NMR

Monday, January 14 | 9:00AM - 12:15PM
New Methods in Solid State NMR
Room: Ballroom 2-3

Speaker 3 of 7
Lynette Cegelski, Stanford University, USA
Short Talk: Structure and Function of Bacterial Amyloid Fibers and Biofilms

Monday, January 14 | 9:00AM - 12:15PM
New Methods in Solid State NMR
Room: Ballroom 2-3

Speaker 4 of 7
Tatyana Polenova, University of Delaware, USA
Magic Angle Spinning Solid-State NMR Studies of HIV-1 Protein Assemblies

Monday, January 14 | 9:00AM - 12:15PM
New Methods in Solid State NMR
Room: Ballroom 2-3

Speaker 5 of 7
Cody L. Hoop, University of Pittsburgh, USA
Short Talk: Structural and Motional Investigations of Polyglutamine-Containing Amyloid Fibrils by Magic-Angle-Spinning Solid-State NMR

Monday, January 14 | 9:00AM - 12:15PM
New Methods in Solid State NMR
Room: Ballroom 2-3

Speaker 6 of 7
Bernd Reif, Technische Universität München, Germany
Amyloid Aggregates and Large Soluble Protein Complexes

Monday, January 14 | 9:00AM - 12:15PM
New Methods in Solid State NMR
Room: Ballroom 2-3

Speaker 7 of 7
Chad M. Rienstra, University of Illinois at Urbana-Champaign, USA
High-Resolution Protein Structures by Magic-Angle Spinning NMR

Monday, January 14 | 9:40AM - 10:00AM
Coffee Break
Room: Ballroom Lobby


Monday, January 14 | 12:15PM - 1:00PM
Poster Setup
Room: Superior


Monday, January 14 | 12:15PM - 4:30PM
On Own for Lunch and Recreation


Monday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior


Monday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, January 14 | 5:00PM - 7:00PM
NMR in Cells and Cell Extracts
Room: Ballroom 2-3

Speaker 1 of 5
* Mitsu Ikura, University of Toronto, Canada

Monday, January 14 | 5:00PM - 7:00PM
NMR in Cells and Cell Extracts
Room: Ballroom 2-3

Speaker 2 of 5
Philipp Selenko, Leibniz-Institut für Molekulare Pharmakologie (FMP-Berlin), Germany
In-Cell NMR of Post-Translational Protein Modifications

Monday, January 14 | 5:00PM - 7:00PM
NMR in Cells and Cell Extracts
Room: Ballroom 2-3

Speaker 3 of 5
Masahiro Shirakawa, Kyoto University, Japan
In-Cell NMR Spectroscopy of Proteins inside Living Cells

Monday, January 14 | 5:00PM - 7:00PM
NMR in Cells and Cell Extracts
Room: Ballroom 2-3

Speaker 4 of 5
Christopher B. Marshall, University Health Network, Canada
Short Talk: Probing the GTPase Cycle with Real-Time NMR: GAP and GEF Activities in Whole Cell Extracts

Monday, January 14 | 5:00PM - 7:00PM
NMR in Cells and Cell Extracts
Room: Ballroom 2-3

Speaker 5 of 5
Teresa W. M. Fan, University of Kentucky Markey Cancer Center, USA
Stable Isotope-Resolved Metabolomic (SIRM) Approach to Measuring Metabolic Dynamics in Cells and Whole Organisms

Monday, January 14 | 7:00PM - 7:15PM
Lightning Talks
Room: Ballroom 2-3

Speaker 1 of 1
* Gerhard Wagner, Harvard Medical School, USA

Monday, January 14 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby


Monday, January 14 | 7:45PM - 10:00PM
Poster Session 1
Room: Superior


Tuesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, January 15 | 8:00AM - 11:15AM
Elucidating Protein Structure and Function
Room: Ballroom 2-3

Speaker 1 of 7
* John L. Markley, University of Wisconsin-Madison, USA

Tuesday, January 15 | 8:00AM - 11:15AM
Elucidating Protein Structure and Function
Room: Ballroom 2-3

Speaker 2 of 7
Kevin H. Gardner, CUNY Advanced Science Research Center, USA
Natural and Artificial Control of the Mammalian Hypoxia Response

Tuesday, January 15 | 8:00AM - 11:15AM
Elucidating Protein Structure and Function
Room: Ballroom 2-3

Speaker 3 of 7
Mitsu Ikura, University of Toronto, Canada
Dissecting Cancer Cell Signalling and Ion Channel Gating Mechanisms by NMR

Tuesday, January 15 | 8:00AM - 11:15AM
Elucidating Protein Structure and Function
Room: Ballroom 2-3

Speaker 4 of 7
Angela M. Gronenborn, University of Pittsburgh, USA
Interactions between HIV Accessory Proteins and Their Cellular Targets

Tuesday, January 15 | 8:00AM - 11:15AM
Elucidating Protein Structure and Function
Room: Ballroom 2-3

Speaker 5 of 7
Katherine A. Henzler-Wildman, University of Wisconsin-Madison, USA
Asymmetry and Exchange in the Mechanism of Multidrug Efflux by EmrE

Tuesday, January 15 | 8:00AM - 11:15AM
Elucidating Protein Structure and Function
Room: Ballroom 2-3

Speaker 6 of 7
Sharon L. Campbell, University of North Carolina at Chapel Hill, USA
Short Talk: Ras Activity Regulation by Monoubiquitination

Tuesday, January 15 | 8:00AM - 11:15AM
Elucidating Protein Structure and Function
Room: Ballroom 2-3

Speaker 7 of 7
David Fushman, University of Maryland, USA
Short Talk: Deciphering the “Ubiquitin Code”

Tuesday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, January 15 | 11:15AM - 1:00PM
Poster Setup
Room: Superior


Tuesday, January 15 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Tuesday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior


Tuesday, January 15 | 2:30PM - 4:30PM
Workshop: Methods for Sample Production, Labeling and Measur
ing
Room: Ballroom 2-3

Speaker 1 of 7
* Gerhard Wagner, Harvard Medical School, USA

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop: Methods for Sample Production, Labeling and Measur
ing
Room: Ballroom 2-3

Speaker 2 of 7
Scott A. McCallum, Rensselaer Polytechnic Institute, USA
Investigating the Role of Heparin in the Cooperative Assembly of the VEGF Signaling Complex using Novel 13C/15N Enrichment and Spin-Labeling Approaches

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop: Methods for Sample Production, Labeling and Measur
ing
Room: Ballroom 2-3

Speaker 3 of 7
Russell Spencer-Smith, University of Illinois at Chicago, USA
Utilizing Reductive Lysine Methylations in NMR Structural Studies of G-Protein Coupled Receptors

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop: Methods for Sample Production, Labeling and Measur
ing
Room: Ballroom 2-3

Speaker 4 of 7
Franz Hagn, Harvard Medical School, USA, USA
Size-Optimized Phospholipid Bilayer Nanodiscs for the NMR Structure Determination of Membrane Proteins

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop: Methods for Sample Production, Labeling and Measur
ing
Room: Ballroom 2-3

Speaker 5 of 7
Sarah Ann Monti, University of Maryland, Baltimore County, USA
Characterization of the Monomeric Conformation of the HIV-1 RNA 5’-Untranslated Region

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop: Methods for Sample Production, Labeling and Measur
ing
Room: Ballroom 2-3

Speaker 6 of 7
Erik R. P. Zuiderweg, University of Michigan, USA
EZ-ASSIGN: An Algorithm for the Evaluation of Partial Protein Backbone Assignments from Incomplete Triple-Resonance Data

Tuesday, January 15 | 2:30PM - 4:30PM
Workshop: Methods for Sample Production, Labeling and Measur
ing
Room: Ballroom 2-3

Speaker 7 of 7
Brian E. Coggins, Duke University Medical Center, USA
Getting Structures Faster: Putting Sparse Sampling and New Processing Methods to Work in Determining Protein Global Folds

Tuesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, January 15 | 5:00PM - 7:00PM
Nucleotides and Nucleotide/Protein Complexes
Room: Ballroom 2-3

Speaker 1 of 5
* Angela M. Gronenborn, University of Pittsburgh, USA

Tuesday, January 15 | 5:00PM - 7:00PM
Nucleotides and Nucleotide/Protein Complexes
Room: Ballroom 2-3

Speaker 2 of 5
Juli Feigon, University of California, Los Angeles, USA
The Architecture of Telomerase

Tuesday, January 15 | 5:00PM - 7:00PM
Nucleotides and Nucleotide/Protein Complexes
Room: Ballroom 2-3

Speaker 3 of 5
Walter J. Chazin, Vanderbilt University, USA
Architecture and Remodeling of Modular Multi-Domain Proteins in Genome Maintenance Machines

Tuesday, January 15 | 5:00PM - 7:00PM
Nucleotides and Nucleotide/Protein Complexes
Room: Ballroom 2-3

Speaker 4 of 5
Michael A. Durney, Harvard University, USA
Short Talk: Equilibrium-Dependent Ribosomal Recoding Mechanisms in RNA Viruses

Tuesday, January 15 | 5:00PM - 7:00PM
Nucleotides and Nucleotide/Protein Complexes
Room: Ballroom 2-3

Speaker 5 of 5
Michael Sattler, Helmholtz Zentrum München & Technische Universität München, Germany
Regulation of Spliceosome Assembly and Peroxisomal Biogenesis by Posttranslational Modification

Tuesday, January 15 | 7:00PM - 7:15PM
Lightning Talks
Room: Ballroom 2-3

Speaker 1 of 1
* Marc Baldus, Utrecht University, Netherlands

Tuesday, January 15 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby


Tuesday, January 15 | 7:45PM - 10:00PM
Poster Session 2
Room: Superior


Wednesday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, January 16 | 8:00AM - 11:00AM
Membrane Proteins
Room: Ballroom 2-3

Speaker 1 of 6
* Ichio Shimada, University of Tokyo, Japan

Wednesday, January 16 | 8:00AM - 11:00AM
Membrane Proteins
Room: Ballroom 2-3

Speaker 2 of 6
Marc Baldus, Utrecht University, Netherlands
NMR Studies at the Interface of Cellular and Structural Biology

Wednesday, January 16 | 8:00AM - 11:00AM
Membrane Proteins
Room: Ballroom 2-3

Speaker 3 of 6
Linda Columbus, University of Virginia, USA
Structure, Folding and Functional Studies of Opacity-Associated (Opa) Proteins from Neisseria gonorrhoeae

Wednesday, January 16 | 8:00AM - 11:00AM
Membrane Proteins
Room: Ballroom 2-3

Speaker 4 of 6
James Jeiwen Chou, Harvard Medical School, USA
An NMR View of Membrane Transporters and Channels

Wednesday, January 16 | 8:00AM - 11:00AM
Membrane Proteins
Room: Ballroom 2-3

Speaker 5 of 6
Mohammad T. Mazhab-Jafari, University of Toronto, Canada
Short Talk: Structure and Function of Lipidated, Membrane-Tethered Rheb: NMR Studies of a GTPase on Nanodiscs

Wednesday, January 16 | 8:00AM - 11:00AM
Membrane Proteins
Room: Ballroom 2-3

Speaker 6 of 6
Senyon Choe, The Salk Institute, USA
Facile NMR Structure Determination of Human Membrane Proteins

Wednesday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Wednesday, January 16 | 11:00AM - 1:00PM
Poster Setup
Room: Superior


Wednesday, January 16 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Wednesday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior


Wednesday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, January 16 | 5:00PM - 7:00PM
Drug Targets, NMR in Industry
Room: Ballroom 2-3

Speaker 1 of 5
* Erik R. P. Zuiderweg, University of Michigan, USA

Wednesday, January 16 | 5:00PM - 7:00PM
Drug Targets, NMR in Industry
Room: Ballroom 2-3

Speaker 2 of 5
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Cancer Drug Discovery Using Fragment-Based Methods

Wednesday, January 16 | 5:00PM - 7:00PM
Drug Targets, NMR in Industry
Room: Ballroom 2-3

Speaker 3 of 5
Teresa Carlomagno, Universität Hannover, Germany
Structural Mechanisms of Drugs Studied by INPHARMA-NMR: Methodology and Applications

Wednesday, January 16 | 5:00PM - 7:00PM
Drug Targets, NMR in Industry
Room: Ballroom 2-3

Speaker 4 of 5
Maurizio Pellecchia, University of California, Riverside, USA
Short Talk: HTS by NMR for the Design of Inhibitors of Protein-Protein Interactions

Wednesday, January 16 | 5:00PM - 7:00PM
Drug Targets, NMR in Industry
Room: Ballroom 2-3

Speaker 5 of 5
Daniel F. Wyss, Merck Research Laboratories, USA
FBDD on a Tough Target Starts to Yield – Discovery of Orally Active, Brain-Penetrant BACE1 Inhibitors

Wednesday, January 16 | 7:00PM - 7:15PM
Lightning Talks
Room: Ballroom 2-3

Speaker 1 of 1
* Angela M. Gronenborn, University of Pittsburgh, USA

Wednesday, January 16 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby


Wednesday, January 16 | 7:45PM - 10:00PM
Poster Session 3
Room: Superior


Thursday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, January 17 | 8:00AM - 11:15AM
Solution NMR Methods
Room: Ballroom 2-3

Speaker 1 of 7
* Robert Kaptein, University of Utrecht, Netherlands

Thursday, January 17 | 8:00AM - 11:15AM
Solution NMR Methods
Room: Ballroom 2-3

Speaker 2 of 7
Ad Bax, NIDDK, National Institutes of Health, USA
Extending the Empirical Limits of Chemical Shifts

Thursday, January 17 | 8:00AM - 11:15AM
Solution NMR Methods
Room: Ballroom 2-3

Speaker 3 of 7
Gottfried Otting, Australian National University, Australia
Paramagnetic Probes for NMR Studies

Thursday, January 17 | 8:00AM - 11:15AM
Solution NMR Methods
Room: Ballroom 2-3

Speaker 4 of 7
Gerhard Wagner, Harvard Medical School, USA
New NMR Experiments for Challenging Proteins

Thursday, January 17 | 8:00AM - 11:15AM
Solution NMR Methods
Room: Ballroom 2-3

Speaker 5 of 7
Bernhard Brutscher, Institut de Biologie Structurale, France
Fast-Pulsing NMR Techniques: Applications to the Study of Protein Folding and Structural Disorder

Thursday, January 17 | 8:00AM - 11:15AM
Solution NMR Methods
Room: Ballroom 2-3

Speaker 6 of 7
Clemens G. Anklin, Bruker BioSpin Corporation, USA
Short Talk: Continuous Temperature Measurement Inside NMR Samples, the NMR-Thermometer

Thursday, January 17 | 8:00AM - 11:15AM
Solution NMR Methods
Room: Ballroom 2-3

Speaker 7 of 7
G. Marius Clore, NIDDK, National Institutes of Health, USA
Short Talk: Atomic Resolution Dynamics on the Surface of Amyloid beta Protofibrils Probed by Dark State Exchange Saturation Transfer (DEST) Spectroscopy

Thursday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Thursday, January 17 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Thursday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, January 17 | 5:00PM - 7:00PM
Folding and Disease
Room: Ballroom 3

Speaker 1 of 5
* Kevin H. Gardner, CUNY Advanced Science Research Center, USA

Thursday, January 17 | 5:00PM - 7:00PM
Folding and Disease
Room: Ballroom 3

Speaker 2 of 5
Ichio Shimada, University of Tokyo, Japan
Functional Equilibrium of Membrane Proteins

Thursday, January 17 | 5:00PM - 7:00PM
Folding and Disease
Room: Ballroom 3

Speaker 3 of 5
Robert Tycko, NIDDK, National Institutes of Health, USA
Amyloid Fibril Structures, in vitro and ex vivo

Thursday, January 17 | 5:00PM - 7:00PM
Folding and Disease
Room: Ballroom 3

Speaker 4 of 5
Anja Böckmann, CNRS, France
Short Talk: The Whole Is Different from the Sum of the Pieces: Full-Length Prions vs. Isolated Domains

Thursday, January 17 | 5:00PM - 7:00PM
Folding and Disease
Room: Ballroom 3

Speaker 5 of 5
Kurt Wüthrich, ETH Zürich, Switzerland
Solution NMR with G Protein-Coupled Receptors (GPCRs)

Thursday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1-2


Thursday, January 17 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 1-2


Thursday, January 17 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 1-2


Friday, January 18 | 10:25AM - 10:25AM
Departure


*Session Chair.