Web Desc
Emerging Topics in Immune System Plasticity
Organizer(s): Steven L. Reiner, Erika L. Pearce and Yasmine Belkaid
Date: January 15 - 20, 2013
Location: Santa Fe Community Convention Center, Santa Fe, NM, USA
Sponsored by Takeda Pharmaceutical Company Limited
For important information on the coronavirus, please click here
Summary of Meeting:
The immune system is a multi-cellular network that adapts to external threats. Immune cells cooperate with other defenses, such as barriers, to prevent breach and to reject invaders by selecting the right responses while inflicting minimal damage to the host. A key feature of the immune system is its fluidity and ability to traverse temporal and spatial boundaries. Furthermore, immune system dynamics involve cellular expansion, provisional cellular niches, altered transcription and balancing differentiation with regeneration. This meeting will bring together diverse researchers to better understand how immune reactions are orchestrated to contend with the extrinsic information and metabolic demands of cellular differentiation, function and homeostasis. The aims of the meeting are to: 1) Unveil the nature of cell-to-cell communication that occurs during different stages of the immune response; 2) Reveal the latest understanding of extrinsic and intrinsic signaling networks that dictate lymphocyte and other immune cell fates; 3) Increase awareness of metabolic control of immune cell fate and function; and 4) Provide a format for the training and mentoring of new investigators and pre- and post-doctoral students. We anticipate that this meeting will alter the field's view of immune mobilization and execution, and will help to break barriers between immunology and other disciplines.
Scholarship Deadline: September 18 2012
Discounted Abstract Deadline: September 18 2012
Abstract Deadline: October 31 2012
Discounted Registration Deadline: November 14 2012
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Takeda Pharmaceutical Company Limited
We gratefully acknowledge additional support for this conference from:
BioLegendSeahorse Bioscience, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI102514-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 15 | 4:00PM - 8:00PM
Arrival and Registration
Room: Lobby


Wednesday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney Ballroom C-E


Wednesday, January 16 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sweeney Ballroom F

Speaker 1 of 4
* Steven L. Reiner, Columbia University, USA

Wednesday, January 16 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sweeney Ballroom F

Speaker 2 of 4
* Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany

Wednesday, January 16 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sweeney Ballroom F

Speaker 3 of 4
* Yasmine Belkaid, NIAID, National Institutes of Health, USA

Wednesday, January 16 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sweeney Ballroom F

Speaker 4 of 4
Douglas R. Green, St. Jude Children's Research Hospital, USA
No Free Lunches: LC3-Associated Phagocytosis, a Process that Links Phagocytosis and Autophagy, and its Possible Roles in Inflammation, Innate Immunity, and Homeostasis

Wednesday, January 16 | 9:00AM - 11:15AM
Novel Innate and Adaptive Cell Types
Room: Sweeney Ballroom F

Speaker 1 of 5
* Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA

Wednesday, January 16 | 9:00AM - 11:15AM
Novel Innate and Adaptive Cell Types
Room: Sweeney Ballroom F

Speaker 2 of 5
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Signaling Innate Immunity and Inflammation

Wednesday, January 16 | 9:00AM - 11:15AM
Novel Innate and Adaptive Cell Types
Room: Sweeney Ballroom F

Speaker 3 of 5
Brigitta Stockinger, Francis Crick Institute, UK
Th17 Cell Plasticity: For Better or for Worse

Wednesday, January 16 | 9:00AM - 11:15AM
Novel Innate and Adaptive Cell Types
Room: Sweeney Ballroom F

Speaker 4 of 5
Thomas Hoyler, Institute of Medical Microbiology and Hygiene, Germany
Short Talk: The Transcription Factor GATA3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells

Wednesday, January 16 | 9:00AM - 11:15AM
Novel Innate and Adaptive Cell Types
Room: Sweeney Ballroom F

Speaker 5 of 5
David Artis, Weill Cornell Medical College, USA
Mechanisms of Immune Regulation at Barrier Surfaces

Wednesday, January 16 | 9:40AM - 10:00AM
Coffee Break
Room: Sweeney Ballroom C-E


Wednesday, January 16 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Wednesday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom C-E


Wednesday, January 16 | 5:00PM - 7:00PM
Metabolic Regulation of the Immune Response
Room: Sweeney Ballroom F

Speaker 1 of 5
* Igor E. Brodsky, University of Pennsylvania, USA

Wednesday, January 16 | 5:00PM - 7:00PM
Metabolic Regulation of the Immune Response
Room: Sweeney Ballroom F

Speaker 2 of 5
Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Control of T Cell Function

Wednesday, January 16 | 5:00PM - 7:00PM
Metabolic Regulation of the Immune Response
Room: Sweeney Ballroom F

Speaker 3 of 5
Madhusudhanan Sukumar, NCI, National Institutes of Health, USA
Short Talk: Glycolytic Flux Limits the Generation of Memory CD8+ T Cells

Wednesday, January 16 | 5:00PM - 7:00PM
Metabolic Regulation of the Immune Response
Room: Sweeney Ballroom F

Speaker 4 of 5
Russell G. Jones, Van Andel Research Institute, USA
Short Talk: Regulation of Metabolic Plasticity and T Cell Function by Cellular Energy Sensors

Wednesday, January 16 | 5:00PM - 7:00PM
Metabolic Regulation of the Immune Response
Room: Sweeney Ballroom F

Speaker 5 of 5
Andrew N. Macintyre, Duke University Medical Center, USA
Short Talk: The Role of GLUT1 Mediated Glucose Metabolism in T Cell Development, Differentiation and Function

Wednesday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney Ballroom C-E


Thursday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney Ballroom C-E


Thursday, January 17 | 8:00AM - 11:15AM
Targeted Control of Immune Responses
Room: Sweeney Ballroom F

Speaker 1 of 7
* Steven L. Reiner, Columbia University, USA

Thursday, January 17 | 8:00AM - 11:15AM
Targeted Control of Immune Responses
Room: Sweeney Ballroom F

Speaker 2 of 7
John J. O'Shea, NIAMS, National Institutes of Health, USA
Therapeutic Application of Jak/Stat Inhibition

Thursday, January 17 | 8:00AM - 11:15AM
Targeted Control of Immune Responses
Room: Sweeney Ballroom F

Speaker 3 of 7
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
FoxP3 Function in Regulatory T Cells

Thursday, January 17 | 8:00AM - 11:15AM
Targeted Control of Immune Responses
Room: Sweeney Ballroom F

Speaker 4 of 7
Ming O. Li, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Novel Foxo1-Dependent Transcriptional Programs Control Treg Cell Function

Thursday, January 17 | 8:00AM - 11:15AM
Targeted Control of Immune Responses
Room: Sweeney Ballroom F

Speaker 5 of 7
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Commensal-Pathogen Interactions at Barrier Sites

Thursday, January 17 | 8:00AM - 11:15AM
Targeted Control of Immune Responses
Room: Sweeney Ballroom F

Speaker 6 of 7
Maria Ciofani, Skirball Institute of Biomolecular Medicine, USA
Short Talk: The Global Th17 Regulatory Network Uncovers Mechanisms of Helper Cell Plasticity

Thursday, January 17 | 8:00AM - 11:15AM
Targeted Control of Immune Responses
Room: Sweeney Ballroom F

Speaker 7 of 7
John T. Chang, University of California, San Diego, USA
Specifiying T Lymphocyte Fates

Thursday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney Ballroom C-E


Thursday, January 17 | 11:15AM - 1:00PM
Poster Setup
Room: Sweeney Ballroom C-E


Thursday, January 17 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Thursday, January 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney Ballroom C-E


Thursday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom C-E


Thursday, January 17 | 5:00PM - 7:00PM
Orchestrating Humoral Immunity
Room: Sweeney Ballroom F

Speaker 1 of 5
* John J. O'Shea, NIAMS, National Institutes of Health, USA

Thursday, January 17 | 5:00PM - 7:00PM
Orchestrating Humoral Immunity
Room: Sweeney Ballroom F

Speaker 2 of 5
Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
Plasticity of Dendritic Cells during Pathogen Response

Thursday, January 17 | 5:00PM - 7:00PM
Orchestrating Humoral Immunity
Room: Sweeney Ballroom F

Speaker 3 of 5
Jason G. Cyster, HHMI/University of California, San Francisco, USA
Emergence of a gamma/delta T Cell Subsetand iIs Role in Barrier Immunity

Thursday, January 17 | 5:00PM - 7:00PM
Orchestrating Humoral Immunity
Room: Sweeney Ballroom F

Speaker 4 of 5
Burton E. Barnett, Genomics Institute of the Novartis Research Foundation, USA
Short Talk: Asymmetric Division of Germinal Center B Cells

Thursday, January 17 | 5:00PM - 7:00PM
Orchestrating Humoral Immunity
Room: Sweeney Ballroom F

Speaker 5 of 5
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Human B Cell Memory

Thursday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney Ballroom C-E


Thursday, January 17 | 7:30PM - 10:00PM
Poster Session 1
Room: Sweeney Ballroom C-E


Friday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney Ballroom C-E


Friday, January 18 | 8:00AM - 11:00AM
Host-Microbe Interface in the Immune Response
Room: Sweeney Ballroom F

Speaker 1 of 6
* Christopher A. Hunter, University of Pennsylvania, USA

Friday, January 18 | 8:00AM - 11:00AM
Host-Microbe Interface in the Immune Response
Room: Sweeney Ballroom F

Speaker 2 of 6
Eric G. Pamer, University of Chicago, USA
Innate Immune Responses to Intestinal Bacteria

Friday, January 18 | 8:00AM - 11:00AM
Host-Microbe Interface in the Immune Response
Room: Sweeney Ballroom F

Speaker 3 of 6
Shipra Vaishnava, University of Texas Southwestern Medical Center, USA
Short Talk: Bacteria-Regulated Vitamin A Metabolism in the Intestine

Friday, January 18 | 8:00AM - 11:00AM
Host-Microbe Interface in the Immune Response
Room: Sweeney Ballroom F

Speaker 4 of 6
Akihiko Yoshimura, Keio University, Japan
Suppression of Intestinal Inflammation by Signals of IL-10, TGF-beta and Novel Factors

Friday, January 18 | 8:00AM - 11:00AM
Host-Microbe Interface in the Immune Response
Room: Sweeney Ballroom F

Speaker 5 of 6
Lisa L. Korn, University of Pennsylvania, USA
Short Talk: CD4 T Cells Regulate Intestinal Innate Lymphoid Cells Homeostasis

Friday, January 18 | 8:00AM - 11:00AM
Host-Microbe Interface in the Immune Response
Room: Sweeney Ballroom F

Speaker 6 of 6
Igor E. Brodsky, University of Pennsylvania, USA
Short Talk: Oxidative Metabolism Mediates NLRP3 Inflammasome Evasion by Intracellular Salmonella

Friday, January 18 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney Ballroom C-E


Friday, January 18 | 11:00AM - 1:00PM
Poster Setup
Room: Sweeney Ballroom C-E


Friday, January 18 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Friday, January 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney Ballroom C-E


Friday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom C-E


Friday, January 18 | 5:00PM - 7:00PM
Plasticity of the Microenvironment
Room: Sweeney Ballroom F

Speaker 1 of 7
* Eric G. Pamer, University of Chicago, USA

Friday, January 18 | 5:00PM - 7:00PM
Plasticity of the Microenvironment
Room: Sweeney Ballroom F

Speaker 2 of 7
Shannon J. Turley, Genentech, Inc., USA
Regulation of Leukocyte Function by Lymph Node Stroma

Friday, January 18 | 5:00PM - 7:00PM
Plasticity of the Microenvironment
Room: Sweeney Ballroom F

Speaker 3 of 7
Li Wang, Medical College of Wisconsin, USA
Short Talk: Manipulating the Tumor Microenvironment by Targeting VISTA

Friday, January 18 | 5:00PM - 7:00PM
Plasticity of the Microenvironment
Room: Sweeney Ballroom F

Speaker 4 of 7
Chengcheng Jin, Massachusetts Institute of Technology, USA
Short Talk: Inflammasomes Regulate Metabolism through Modulation of Intestinal Microbiota

Friday, January 18 | 5:00PM - 7:00PM
Plasticity of the Microenvironment
Room: Sweeney Ballroom F

Speaker 5 of 7
Mandy J. McGeachy, University of Pittsburgh, USA
Short Talk: IL-23 Drives Memory Th17 Expansion and Plasticity in vivo

Friday, January 18 | 5:00PM - 7:00PM
Plasticity of the Microenvironment
Room: Sweeney Ballroom F

Speaker 6 of 7
Eric T. Clambey, University of Colorado Denver, USA
Short Talk: Hypoxia via Hypoxia Inducible Factor (HIF)-1 alpha Promotes the Generation of IL-10 Producing T Cells

Friday, January 18 | 5:00PM - 7:00PM
Plasticity of the Microenvironment
Room: Sweeney Ballroom F

Speaker 7 of 7
Grégoire Lauvau, Albert Einstein College of Medicine, USA
Short Talk: Switching on Memory CD8+ T Cells

Friday, January 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney Ballroom C-E


Friday, January 18 | 7:30PM - 10:00PM
Poster Session 2
Room: Sweeney Ballroom C-E


Saturday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney Ballroom C-E


Saturday, January 19 | 8:00AM - 11:15AM
Cell Fate Specification of Lymphocytes
Room: Sweeney Ballroom F

Speaker 1 of 8
* Shannon J. Turley, Genentech, Inc., USA

Saturday, January 19 | 8:00AM - 11:15AM
Cell Fate Specification of Lymphocytes
Room: Sweeney Ballroom F

Speaker 2 of 8
Amy J. Wagers, Harvard University, USA
Plasticity in the Regulation of Tissue Homeostasis and Repair with Age

Saturday, January 19 | 8:00AM - 11:15AM
Cell Fate Specification of Lymphocytes
Room: Sweeney Ballroom F

Speaker 3 of 8
Steven L. Reiner, Columbia University, USA
Generating and Regenerating Immunity

Saturday, January 19 | 8:00AM - 11:15AM
Cell Fate Specification of Lymphocytes
Room: Sweeney Ballroom F

Speaker 4 of 8
Luca Gattinoni, NCI, National Institutes of Health, USA
Short Talk: T Memory Stem Cells Sustain the Long-Term Maintenance of T Cell Memory

Saturday, January 19 | 8:00AM - 11:15AM
Cell Fate Specification of Lymphocytes
Room: Sweeney Ballroom F

Speaker 5 of 8
Alexander Tarakhovsky, Rockefeller University, USA
Signalling Control of Epigenetic Fitness

Saturday, January 19 | 8:00AM - 11:15AM
Cell Fate Specification of Lymphocytes
Room: Sweeney Ballroom F

Speaker 6 of 8
Rebecca Mathew, University of Chicago, USA
Short Talk: BTB-ZF Factors Recruit the E3 Ligase Cullin 3 to Regulate Lymphoid Effector Programs

Saturday, January 19 | 8:00AM - 11:15AM
Cell Fate Specification of Lymphocytes
Room: Sweeney Ballroom F

Speaker 7 of 8
Ananda W. Goldrath, University of California, San Diego, USA
Short Talk: Hypoxia Inducible Factors Override CD8+ T Cell Exhaustion in Chronic Infection

Saturday, January 19 | 8:00AM - 11:15AM
Cell Fate Specification of Lymphocytes
Room: Sweeney Ballroom F

Speaker 8 of 8
Taiga Tamiya, Teijin Limited, Japan
Short Talk: Smad2/3 Signaling Is Essential for TGF-beta-Mediated Th9 Development

Saturday, January 19 | 9:00AM - 9:20AM
Coffee Break
Room: Sweeney Ballroom C-E


Saturday, January 19 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Saturday, January 19 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom C-E


Saturday, January 19 | 5:00PM - 5:45PM
Dynamics of Cellular Plasticity in vivo
Room: Sweeney Ballroom F

Speaker 1 of 2
* Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany

Saturday, January 19 | 5:00PM - 5:45PM
Dynamics of Cellular Plasticity in vivo
Room: Sweeney Ballroom F

Speaker 2 of 2
Christopher A. Hunter, University of Pennsylvania, USA
Imaging Plasticity in T Cell Behavior

Saturday, January 19 | 5:45PM - 6:45PM
Closing Keynote Address
Room: Sweeney Ballroom F

Speaker 1 of 1
Elaine V. Fuchs, Rockefeller University, USA
Crosstalk between Stem Cells and their Microenvironment

Saturday, January 19 | 6:45PM - 7:45PM
Social Hour with Lite Bites
Room: Sweeney Ballroom C-E


Saturday, January 19 | 8:00PM - 11:00PM
Entertainment
Room: Sweeney Ballroom C-E


Saturday, January 19 | 8:00PM - 11:00PM
Cash Bar
Room: Sweeney Ballroom C-E


Sunday, January 20 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.