Web Desc
Metabolic Control of Inflammation and Immunity
Organizer(s): Vishva M. Dixit, Douglas R. Green and Maya Saleh
Date: January 21 - 26, 2013
Location: Beaver Run Resort, Breckenridge, CO, USA
Sponsored by EMD Millipore
Summary of Meeting:
Inflammation and immune responses are energetically costly, as are the infections that elicit them. The interplay of these metabolic demands are complex, and frequently ‘hard-wired’ into the responses. An emerging field is illuminating this interplay of metabolism, inflammation and immunity, and therefore there couldn’t be a better time to have a meeting where scientists who study inflammation and immunity in this context encounter their 'metabolic' counterparts from other fields. IL-1b and IL-18 are potent proinflammatory cytokines that are synthesized as pro-forms and matured by the aspartate-specific cysteine protease, IL-1-converting enzyme (ICE or caspase-1). The caspase-1 activation platform, or inflammasome, contains one of a number of 'sensor' proteins that respond to a bewildering array of inflammatory insults, including the presence of intracellular pathogens, disruption of membrane integrity and mitochondrial reactive oxygen species. Many of these sensors, but not all, are members of the NOD family of intracellular proteins. There are upwards of 30 such proteins encoded in the human genome. This molecular apparatus generates active caspase-1 responsible not only for the proteolytic maturation of IL-1b and IL-18, but also pyroptosis, a pro-inflammatory mode of cell death. While mutations in the NOD sensors have been associated with relatively rare periodic fever syndromes, there is newfound interest in them with the realization that one member (NOD2) is the most commonly mutated gene in inflammatory bowel disease (IBD). Further, there has been the recent insight that mutations in other IBD susceptibility genes, such as ATG16L, lead to activation of the inflammasome, possibly due to a deficit in autophagic efficiency and consequent increase in reactive oxygen species that trigger a NOD sensor. Superimposed on this exciting insight has been the understanding that the NOD sensors also respond to metabolic stress, the hallmark of disease states such as Type 2 diabetes. Inflammasome-mediated inflammation likely drives insulin resistance, as suggested by a recent clinical trial where neutralizing IL-1b led to a decrease in systemic markers of inflammation and improved glycemic control. Other recently emergent data concerns the interplay of metabolism and the innate and adaptive immune responses. Together, these have dramatically underscored the importance of inflammation and immunity in metabolic disease states.
Scholarship Deadline: September 24 2012
Discounted Abstract Deadline: September 24 2012
Abstract Deadline: October 24 2012
Discounted Registration Deadline: November 19 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
EMD Millipore
We gratefully acknowledge additional support for this conference from:
AdipoGen InternationalR&D Systems, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-04
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, January 21 | 4:00PM - 7:30PM
Arrival and Registration
Room: Foyer


Monday, January 21 | 6:15PM - 7:15PM
Refreshments
Room: Foyer


Monday, January 21 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Colorado Ballroom

Speaker 1 of 3
* Vishva M. Dixit, Genentech, Inc., USA

Monday, January 21 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Colorado Ballroom

Speaker 2 of 3
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Monday, January 21 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Colorado Ballroom

Speaker 3 of 3
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Inflammasome, Microbiota and Disease

Tuesday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Tuesday, January 22 | 8:00AM - 11:15AM
Metabolism and Signaling
Room: Colorado Ballroom

Speaker 1 of 7
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Tuesday, January 22 | 8:00AM - 11:15AM
Metabolism and Signaling
Room: Colorado Ballroom

Speaker 2 of 7
Jaemyoung Suh, Korea Advanced Institute of Science & Technology, South Korea
Nuclear Receptor Control of Rhythm and Metabolism

Tuesday, January 22 | 8:00AM - 11:15AM
Metabolism and Signaling
Room: Colorado Ballroom

Speaker 3 of 7
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Regulation of Cell Metabolism to Support Proliferation

Tuesday, January 22 | 8:00AM - 11:15AM
Metabolism and Signaling
Room: Colorado Ballroom

Speaker 4 of 7
Ajay Chawla, Merck Research Labs, USA
Innate Control of Metabolism

Tuesday, January 22 | 8:00AM - 11:15AM
Metabolism and Signaling
Room: Colorado Ballroom

Speaker 5 of 7
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Battle of the Master Regulators PPARgamma and PU.1

Tuesday, January 22 | 8:00AM - 11:15AM
Metabolism and Signaling
Room: Colorado Ballroom

Speaker 6 of 7
Holly Legault, Biogen Idec, USA
Short Talk: IRAK4 Inhibition Results in Amelioration of Disease in Diet-Induced Obesity Model

Tuesday, January 22 | 8:00AM - 11:15AM
Metabolism and Signaling
Room: Colorado Ballroom

Speaker 7 of 7
Shannon M. Reilly, University of Michigan, USA
Short Talk: An Inhibitor of the Protein Kinases TBK1/IKKepsilon Improves Obesity-Related Metabolic Dysfunctions

Tuesday, January 22 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, January 22 | 11:15AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Tuesday, January 22 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Tuesday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Tuesday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, January 22 | 5:00PM - 7:15PM
The Inflammasome and Metabolism I
Room: Colorado Ballroom

Speaker 1 of 5
* Maya Saleh, McGill University, Canada

Tuesday, January 22 | 5:00PM - 7:15PM
The Inflammasome and Metabolism I
Room: Colorado Ballroom

Speaker 2 of 5
Vishva M. Dixit, Genentech, Inc., USA
Non-Canonical Inflammasome Activation Targets Caspase-11

Tuesday, January 22 | 5:00PM - 7:15PM
The Inflammasome and Metabolism I
Room: Colorado Ballroom

Speaker 3 of 5
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Fatty Acid-Induced NLRP3 Inflammasome

Tuesday, January 22 | 5:00PM - 7:15PM
The Inflammasome and Metabolism I
Room: Colorado Ballroom

Speaker 4 of 5
Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Mediators of Inflammatory Responses

Tuesday, January 22 | 5:00PM - 7:15PM
The Inflammasome and Metabolism I
Room: Colorado Ballroom

Speaker 5 of 5
Eicke Latz, University of Bonn, Germany
Inflammasome Activation in Atherosclerosis and Alzheimer's Disease

Tuesday, January 22 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Tuesday, January 22 | 7:30PM - 10:00PM
Poster Session 1
Room: Breckenridge Ballroom


Wednesday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Wednesday, January 23 | 8:00AM - 11:15AM
The Inflammasome and Metabolism II
Room: Colorado Ballroom

Speaker 1 of 7
* Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA

Wednesday, January 23 | 8:00AM - 11:15AM
The Inflammasome and Metabolism II
Room: Colorado Ballroom

Speaker 2 of 7
Charles A. Dinarello, University of Colorado Health Sciences Center, USA
How Does the IL-1 Family Control its Own Members?

Wednesday, January 23 | 8:00AM - 11:15AM
The Inflammasome and Metabolism II
Room: Colorado Ballroom

Speaker 3 of 7
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Metabolic Control of Innate Immunity and Inflammation

Wednesday, January 23 | 8:00AM - 11:15AM
The Inflammasome and Metabolism II
Room: Colorado Ballroom

Speaker 4 of 7
Marc Y. Donath, University Hospital Basel, Switzerland
Islet Inflammation in Type 2 and Diabetes

Wednesday, January 23 | 8:00AM - 11:15AM
The Inflammasome and Metabolism II
Room: Colorado Ballroom

Speaker 5 of 7
Vishwa Deep Dixit, Yale University, USA
Inflammasomes and the Regulation of Healthspan

Wednesday, January 23 | 8:00AM - 11:15AM
The Inflammasome and Metabolism II
Room: Colorado Ballroom

Speaker 6 of 7
Menno P. J. de Winther, Academic Medical Center, Netherlands
Short Talk: Myeloid IL-10R1 Deficiency Attenuates Atherosclerosis in Hyperlipidemic LDLR-/- Mice

Wednesday, January 23 | 8:00AM - 11:15AM
The Inflammasome and Metabolism II
Room: Colorado Ballroom

Speaker 7 of 7
Dov Ben Ballak, Radboud University Medical Centre, Netherlands
Short Talk: A Novel IL-1 Family Member: Anti-Inflammatory Actions of IL-37 Protect Against Obesity-Induced Inflammation and Insulin Resistance

Wednesday, January 23 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, January 23 | 11:15AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Wednesday, January 23 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Wednesday, January 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Wednesday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, January 23 | 5:00PM - 7:15PM
Inflammation and Metabolism
Room: Colorado Ballroom

Speaker 1 of 6
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

Wednesday, January 23 | 5:00PM - 7:15PM
Inflammation and Metabolism
Room: Colorado Ballroom

Speaker 2 of 6
Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Mechanisms of Metabolic Inflammation and ER Dysfunction

Wednesday, January 23 | 5:00PM - 7:15PM
Inflammation and Metabolism
Room: Colorado Ballroom

Speaker 3 of 6
Tiffany Horng, ShanghaiTech University, China
Short Talk: A Critical Role for Calcium Mobilization in Activation of the NLRP3 Inflammasome

Wednesday, January 23 | 5:00PM - 7:15PM
Inflammation and Metabolism
Room: Colorado Ballroom

Speaker 4 of 6
Michael Karin, University of California, San Diego, USA
NF-kappaB, Inflammation and Metabolism

Wednesday, January 23 | 5:00PM - 7:15PM
Inflammation and Metabolism
Room: Colorado Ballroom

Speaker 5 of 6
Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Targeting Inflammation in Insulin Resistance and Diabetes

Wednesday, January 23 | 5:00PM - 7:15PM
Inflammation and Metabolism
Room: Colorado Ballroom

Speaker 6 of 6
Greg Steinberg, McMaster University, Canada
Short Talk: AMP-Activated Protein Kinase (AMPK) Links Lipid Metabolism with Innate Immunity and the Therapeutic Effects of Salicylate

Wednesday, January 23 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Wednesday, January 23 | 7:30PM - 10:00PM
Poster Session 2
Room: Breckenridge Ballroom


Thursday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Thursday, January 24 | 8:00AM - 11:15AM
NOD, Microbiota and Metabolism
Room: Colorado Ballroom

Speaker 1 of 7
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Thursday, January 24 | 8:00AM - 11:15AM
NOD, Microbiota and Metabolism
Room: Colorado Ballroom

Speaker 2 of 7
Maya Saleh, McGill University, Canada
Innate Detection Mechanisms and Inflammation in Obesity and Type 2 Diabetes

Thursday, January 24 | 8:00AM - 11:15AM
NOD, Microbiota and Metabolism
Room: Colorado Ballroom

Speaker 3 of 7
Stephen E. Girardin, University of Toronto, Canada
Invasive Bacteria, mTOR and Amino Acid Starvation

Thursday, January 24 | 8:00AM - 11:15AM
NOD, Microbiota and Metabolism
Room: Colorado Ballroom

Speaker 4 of 7
Herbert (Skip) W. Virgin, Vir Biotechnology, USA
Autophagy Proteins in Inflammation and Disease

Thursday, January 24 | 8:00AM - 11:15AM
NOD, Microbiota and Metabolism
Room: Colorado Ballroom

Speaker 5 of 7
Gabriel Nuñez, University of Michigan, USA
Metabolic Control of Pathogen Eradication by the Gut Microbiota



Thursday, January 24 | 8:00AM - 11:15AM
NOD, Microbiota and Metabolism
Room: Colorado Ballroom

Speaker 6 of 7
Jonathan D. Schertzer, McMaster University, Canada
Short Talk: Immunometabolism of NOD1 and NOD2: Yin and Yang of Insulin Resistance during Obesity

Thursday, January 24 | 8:00AM - 11:15AM
NOD, Microbiota and Metabolism
Room: Colorado Ballroom

Speaker 7 of 7
Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Short Talk: Microbiota Control of Wasting Associated with Inflammation and Infection

Thursday, January 24 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, January 24 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Thursday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, January 24 | 5:00PM - 7:00PM
Mitochondria, Inflammation and Metabolism
Room: Colorado Ballroom

Speaker 1 of 5
* Gabriel Nuñez, University of Michigan, USA

Thursday, January 24 | 5:00PM - 7:00PM
Mitochondria, Inflammation and Metabolism
Room: Colorado Ballroom

Speaker 2 of 5
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Cytosolic Immune Surveillance

Thursday, January 24 | 5:00PM - 7:00PM
Mitochondria, Inflammation and Metabolism
Room: Colorado Ballroom

Speaker 3 of 5
Fraser Soares, Canada
Short Talk: Investigating the Role of NLRX1 in Innate Immunity

Thursday, January 24 | 5:00PM - 7:00PM
Mitochondria, Inflammation and Metabolism
Room: Colorado Ballroom

Speaker 4 of 5
Richard M. Siegel, NIAMS, National Institutes of Health, USA
Mitochondrial ROS: Fuel for the Fire of Autoinflammation

Thursday, January 24 | 5:00PM - 7:00PM
Mitochondria, Inflammation and Metabolism
Room: Colorado Ballroom

Speaker 5 of 5
Chih-hao Chang, Washington University in St. Louis, USA
Short Talk: Specific Control of T Cell Effector Function by Warburg Metabolism

Thursday, January 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Friday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Friday, January 25 | 8:00AM - 11:15AM
Metabolic Control of Adaptive Immunity
Room: Colorado Ballroom

Speaker 1 of 7
* Michael Karin, University of California, San Diego, USA

Friday, January 25 | 8:00AM - 11:15AM
Metabolic Control of Adaptive Immunity
Room: Colorado Ballroom

Speaker 2 of 7
Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
HIF1 in the Treg/Th17 Axis

Friday, January 25 | 8:00AM - 11:15AM
Metabolic Control of Adaptive Immunity
Room: Colorado Ballroom

Speaker 3 of 7
Jonathan D. Powell, Johns Hopkins University School of Medicine, USA
A New Model of T Cell Differentiation based on Metabolism

Friday, January 25 | 8:00AM - 11:15AM
Metabolic Control of Adaptive Immunity
Room: Colorado Ballroom

Speaker 4 of 7
Douglas R. Green, St. Jude Children's Research Hospital, USA
No Free Lunches: LC3-Associated Phagocytosis, a Process that Links Phagocytosis and Autophagy, and its Possible Roles in Inflammation, Innate Immunity, and Homeostasis

Friday, January 25 | 8:00AM - 11:15AM
Metabolic Control of Adaptive Immunity
Room: Colorado Ballroom

Speaker 5 of 7
Jeffrey C. Rathmell, Vanderbilt University, USA
Glucose Metabolism in T Cell Activation and CD4 Subsets

Friday, January 25 | 8:00AM - 11:15AM
Metabolic Control of Adaptive Immunity
Room: Colorado Ballroom

Speaker 6 of 7
Laura J. Dixon, Cleveland Clinic, USA
Short Talk: Role of Caspase-1 in High Fat-Induced Non-Alcoholic Steatohepatitis in Mice

Friday, January 25 | 8:00AM - 11:15AM
Metabolic Control of Adaptive Immunity
Room: Colorado Ballroom

Speaker 7 of 7
Tim Hendrikx, Maastricht University, Netherlands
Short Talk: Caspase-1 as a Novel Target for the Detection and Treatment of Non-Alcoholic Steatohepatitis

Friday, January 25 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, January 25 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Friday, January 25 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, January 25 | 5:00PM - 7:00PM
Cell Death, Immunity and Metabolism
Room: Colorado Ballroom

Speaker 1 of 5
* Drew M. Pardoll, Johns Hopkins University School of Medicine, USA

Friday, January 25 | 5:00PM - 7:00PM
Cell Death, Immunity and Metabolism
Room: Colorado Ballroom

Speaker 2 of 5
Kodi S. Ravichandran, University of Virginia, USA
Apoptotic Cell Clearance and the Phagocyte Metabolism

Friday, January 25 | 5:00PM - 7:00PM
Cell Death, Immunity and Metabolism
Room: Colorado Ballroom

Speaker 3 of 5
Nika N. Danial, Dana-Farber Cancer Institute, USA
A Role for Bcl2 Family Members in Diabetes

Friday, January 25 | 5:00PM - 7:00PM
Cell Death, Immunity and Metabolism
Room: Colorado Ballroom

Speaker 4 of 5
Rachel J. Roth Flach, Pfizer Inc., USA
Short Talk: MAP4K4 Is a Novel Regulator of Vascular Inflammation in Insulin Resistance and Atherosclerosis

Friday, January 25 | 5:00PM - 7:00PM
Cell Death, Immunity and Metabolism
Room: Colorado Ballroom

Speaker 5 of 5
Dayoung Oh, University of Texas Southwestern Medical Center, USA
Short Talk: Differential Role of Kupffer Cell vs. Recruited Hepatic Macrophage on Liver Insulin Resistance

Friday, January 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Friday, January 25 | 8:00PM - 11:00PM
Entertainment
Room: Breckenridge Ballroom


Friday, January 25 | 8:00PM - 11:00PM
Cash Bar
Room: Breckenridge Ballroom


Saturday, January 26 | 10:25AM - 10:25AM
Departure


*Session Chair.