Web Desc
Mitochondria, Metabolism and Myocardial Function - Basic Advances to Translational Studies
Organizer(s): Michael N. Sack and Roberta A. Gottlieb
Date: February 03 - 08, 2013
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
The most common causes of heart failure are coronary artery disease, high blood pressure and diabetes. Mitochondrial perturbations have been associated with heart failure itself and with most of the other preceding risk factors. In some cases mitochondrial dysfunction may play a causal role while in others mitochondria are a central target responsible for organ dysfunction. Understanding mitochondrial pathophysiology and identifying ways to ameliorate mitochondrial dysfunction are critical to therapy for cardiovascular disease. The continuous contractile function of the heart is required to sustain blood oxygenation, systemic circulation and nutrient supply to the body. This activity results in an unrelenting demand for energy production that is predominantly supported by mitochondrial oxidative phosphorylation. It is therefore not surprising that the mitochondria comprise about one third of cardiomyocyte volume, exhibit a promiscuous capacity to use energy substrates and possess biologic plasticity to maintain bioenergetic homeostasis. The centrality of mitochondria to sustain cardiac bioenergetics is additionally reflected in the development of cardiac pathology when mitochondria are dysfunctional. To counter this, a myriad of innate adaptive mitochondrial homeostatic programs are being identified. In the last two decades the investigations into mitochondrial biology with ever-increasing discovery technologies have enabled the scientific community to identify many novel programs controlling mitochondrial and metabolic function. The objectives of this conference are to: 1) Highlight the emerging adaptive programs identified in the heart orchestrating optimal mitochondrial homeostasis; 2) Review how the emerging risk factors of obesity and diabetes disrupt mitochondrial and cardiac function; and 3) Explore emerging metabolic targets for therapeutic interventions to modulate mitochondrial and metabolic perturbations associated with cardiac pathology.
Scholarship Deadline: October 3 2012
Discounted Abstract Deadline: October 3 2012
Abstract Deadline: October 31 2012
Discounted Registration Deadline: December 3 2012
Abstacts when book is in proofing process


We gratefully acknowledge additional support for this conference from:
American Heart AssociationSeahorse Bioscience, Inc.


Zhiyong Cheng
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 03 | 4:00PM - 8:00PM
Arrival and Registration
Room: Keystone Lodge Lobby


Monday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Monday, February 04 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 1 of 3
* Michael N. Sack, NHLBI, National Institutes of Health, USA

Monday, February 04 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 2 of 3
* Roberta A. Gottlieb, Cedars-Sinai Medical Center, USA

Monday, February 04 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 3 of 3
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Selective Autophagy and the Cellular Energetic Balance

Monday, February 04 | 9:00AM - 12:00PM
The Biology of Mitochondrial Homeostatic Regulatory Programs
and Cardiac Disease

Room: Grays Peak

Speaker 1 of 7
* E. Dale Abel, University of Iowa, Carver College of Medicine, USA

Monday, February 04 | 9:00AM - 12:00PM
The Biology of Mitochondrial Homeostatic Regulatory Programs
and Cardiac Disease

Room: Grays Peak

Speaker 2 of 7
* Anne A. Knowlton, University of California, Davis, USA

Monday, February 04 | 9:00AM - 12:00PM
The Biology of Mitochondrial Homeostatic Regulatory Programs
and Cardiac Disease

Room: Grays Peak

Speaker 3 of 7
Roberta A. Gottlieb, Cedars-Sinai Medical Center, USA
Mitophagy and Biogenesis

Monday, February 04 | 9:00AM - 12:00PM
The Biology of Mitochondrial Homeostatic Regulatory Programs
and Cardiac Disease

Room: Grays Peak

Speaker 4 of 7
Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Interactions between ER Stress and Mitochondrial Dysfunction in Metabolic Control

Monday, February 04 | 9:00AM - 12:00PM
The Biology of Mitochondrial Homeostatic Regulatory Programs
and Cardiac Disease

Room: Grays Peak

Speaker 5 of 7
Kinya Otsu, UK
Mitochondrial DNA in the Development of Cardiac Inflammation and Dysfunction

Monday, February 04 | 9:00AM - 12:00PM
The Biology of Mitochondrial Homeostatic Regulatory Programs
and Cardiac Disease

Room: Grays Peak

Speaker 6 of 7
Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Autophagy in Cardiac Plasticity

Monday, February 04 | 9:00AM - 12:00PM
The Biology of Mitochondrial Homeostatic Regulatory Programs
and Cardiac Disease

Room: Grays Peak

Speaker 7 of 7
Abhinav Diwan, Washington University School of Medicine, USA
Short Talk: Transcription Factor EB Coordinates Mitochondrial Autophagy with Biogenesis

Monday, February 04 | 9:40AM - 10:00AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 04 | 12:00PM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Monday, February 04 | 12:00PM - 4:30PM
On Own for Lunch and Recreation


Monday, February 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Monday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 04 | 5:00PM - 7:00PM
Regulation of Redox Stress in Cardiovascular Disease
Room: Grays Peak

Speaker 1 of 6
* Lorrie A. Kirshenbaum, University of Manitoba, Canada

Monday, February 04 | 5:00PM - 7:00PM
Regulation of Redox Stress in Cardiovascular Disease
Room: Grays Peak

Speaker 2 of 6
* † Satoaki Matoba, Kyoto Prefectural University of Medicine, Japan

Monday, February 04 | 5:00PM - 7:00PM
Regulation of Redox Stress in Cardiovascular Disease
Room: Grays Peak

Speaker 3 of 6
Junichi Sadoshima, Rutgers New Jersey Medical School, USA
Alternative Autophagy Mediates Mitochondrial Clearance in Response to Energy Stress

Monday, February 04 | 5:00PM - 7:00PM
Regulation of Redox Stress in Cardiovascular Disease
Room: Grays Peak

Speaker 4 of 6
Gerald S. Shadel, The Salk Institute for Biological Studies, USA
Mitochondrial Stress Signaling in Disease and Aging

Monday, February 04 | 5:00PM - 7:00PM
Regulation of Redox Stress in Cardiovascular Disease
Room: Grays Peak

Speaker 5 of 6
John W. Elrod, Lewis Katz School of Medicine at Temple University, USA
Building a Roadmap of Necrotic Cell Death

Monday, February 04 | 5:00PM - 7:00PM
Regulation of Redox Stress in Cardiovascular Disease
Room: Grays Peak

Speaker 6 of 6
Jan Dudek, University of Goettingen, Germany
Short Talk: Cardiolipin Deficiency Affects Respiratory Chain Organization and Function

Monday, February 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Monday, February 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Tuesday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Tuesday, February 05 | 8:00AM - 11:00AM
Metabolic Modulation in the Pathogenesis and Treatment of Ca
rdiac Hypertrophy and Heart Failure

Room: Grays Peak

Speaker 1 of 7
* Jason R. B. Dyck, University of Alberta, Canada

Tuesday, February 05 | 8:00AM - 11:00AM
Metabolic Modulation in the Pathogenesis and Treatment of Ca
rdiac Hypertrophy and Heart Failure

Room: Grays Peak

Speaker 2 of 7
* P. Christian Schulze, Columbia University, USA

Tuesday, February 05 | 8:00AM - 11:00AM
Metabolic Modulation in the Pathogenesis and Treatment of Ca
rdiac Hypertrophy and Heart Failure

Room: Grays Peak

Speaker 3 of 7
Jan F. C. Glatz, Maastricht University, Netherlands
Novel Signaling Pathways Regulating Substrate Switching in the Heart

Tuesday, February 05 | 8:00AM - 11:00AM
Metabolic Modulation in the Pathogenesis and Treatment of Ca
rdiac Hypertrophy and Heart Failure

Room: Grays Peak

Speaker 4 of 7
Martin E. Young, University of Alabama at Birmingham, USA
The Circadian Clock, Metabolic Regulation and Cardiac Pathology

Tuesday, February 05 | 8:00AM - 11:00AM
Metabolic Modulation in the Pathogenesis and Treatment of Ca
rdiac Hypertrophy and Heart Failure

Room: Grays Peak

Speaker 5 of 7
Gary D. Lopaschuk, University of Alberta, Canada
Modulation of Malonyl-CoA and Cardiac Metabolic Consequences

Tuesday, February 05 | 8:00AM - 11:00AM
Metabolic Modulation in the Pathogenesis and Treatment of Ca
rdiac Hypertrophy and Heart Failure

Room: Grays Peak

Speaker 6 of 7
William C. Stanley, University of Sydney, Australia
Mitochondrial Pathology in Heart Failure: Novel Therapeutic Approaches

Tuesday, February 05 | 8:00AM - 11:00AM
Metabolic Modulation in the Pathogenesis and Treatment of Ca
rdiac Hypertrophy and Heart Failure

Room: Grays Peak

Speaker 7 of 7
Konstantinos Drosatos, Temple University School of Medicine, USA
Short Talk: PPARgamma Activation Prevents Cardiac Dysfunction in Sepsis via Stimulation of Energy Production and Prevention of Mitochondrial Loss

Tuesday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 05 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Tuesday, February 05 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Tuesday, February 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Tuesday, February 05 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 05 | 5:00PM - 7:00PM
Emerging Regulatory Programs in the Control of Mitochondria
and Metabolism

Room: Grays Peak

Speaker 1 of 6
* Robert S. Balaban, NHLBI, National Institutes of Health, USA

Tuesday, February 05 | 5:00PM - 7:00PM
Emerging Regulatory Programs in the Control of Mitochondria
and Metabolism

Room: Grays Peak

Speaker 2 of 6
* Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland

Tuesday, February 05 | 5:00PM - 7:00PM
Emerging Regulatory Programs in the Control of Mitochondria
and Metabolism

Room: Grays Peak

Speaker 3 of 6
Elizabeth Murphy, NHLBI, National Institutes of Health, USA
S-Nitrosylation and Regulation of the Mitochondrial Stress Response

Tuesday, February 05 | 5:00PM - 7:00PM
Emerging Regulatory Programs in the Control of Mitochondria
and Metabolism

Room: Grays Peak

Speaker 4 of 6
Michael N. Sack, NHLBI, National Institutes of Health, USA
Acetylation in the Control of Mitochondrial Homeostasis and Mitophagy

Tuesday, February 05 | 5:00PM - 7:00PM
Emerging Regulatory Programs in the Control of Mitochondria
and Metabolism

Room: Grays Peak

Speaker 5 of 6
Eric N. Olson, University of Texas Southwestern Medical Center, USA
A Myocardial Metabolic Axis Controlled by Med13

Tuesday, February 05 | 5:00PM - 7:00PM
Emerging Regulatory Programs in the Control of Mitochondria
and Metabolism

Room: Grays Peak

Speaker 6 of 6
Christoph Koentges, University of Freiburg, Germany
Short Talk: SIRT3 Deficiency Impairs Mitochondrial and Contractile Function But Not Post-Ischemic Contractile Recovery in the Heart

Tuesday, February 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Tuesday, February 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Wednesday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Wednesday, February 06 | 8:00AM - 11:00AM
Nutrient Stressors and the Modulation of Cardiovascular Func
tion

Room: Grays Peak

Speaker 1 of 7
* Michael N. Sack, NHLBI, National Institutes of Health, USA

Wednesday, February 06 | 8:00AM - 11:00AM
Nutrient Stressors and the Modulation of Cardiovascular Func
tion

Room: Grays Peak

Speaker 2 of 7
* Edward Miller, Boston University, USA

Wednesday, February 06 | 8:00AM - 11:00AM
Nutrient Stressors and the Modulation of Cardiovascular Func
tion

Room: Grays Peak

Speaker 3 of 7
Orian S. Shirihai, University of California, Los Angeles, USA
Mitochondrial Dynamics in Quality Control and Bioenergetics

Wednesday, February 06 | 8:00AM - 11:00AM
Nutrient Stressors and the Modulation of Cardiovascular Func
tion

Room: Grays Peak

Speaker 4 of 7
E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Obesity and Fatty Acid-Mediated Disruption of Cardiac Mitochondrial Function and Autophagy

Wednesday, February 06 | 8:00AM - 11:00AM
Nutrient Stressors and the Modulation of Cardiovascular Func
tion

Room: Grays Peak

Speaker 5 of 7
Jason R. B. Dyck, University of Alberta, Canada
Caloric Restriction, Resveratrol and Cardiovascular Function

Wednesday, February 06 | 8:00AM - 11:00AM
Nutrient Stressors and the Modulation of Cardiovascular Func
tion

Room: Grays Peak

Speaker 6 of 7
Daniel P. Kelly, University of Pennsylvania, USA
Myocyte Lipotoxicity Screening to Delineate Mechanisms and Drug Targets

Wednesday, February 06 | 8:00AM - 11:00AM
Nutrient Stressors and the Modulation of Cardiovascular Func
tion

Room: Grays Peak

Speaker 7 of 7
P. Christian Schulze, Columbia University, USA
Short Talk: Inhibition of de novo Ceramide Synthesis Improves Myocardial Function in Chronic Ischemic Cardiomyopathy

Wednesday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 06 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Wednesday, February 06 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Wednesday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Wednesday, February 06 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 06 | 5:00PM - 7:00PM
Emerging Technologies to Characterize Mitochondrial and Meta
bolic Functioning

Room: Grays Peak

Speaker 1 of 6
* Daniel P. Kelly, University of Pennsylvania, USA

Wednesday, February 06 | 5:00PM - 7:00PM
Emerging Technologies to Characterize Mitochondrial and Meta
bolic Functioning

Room: Grays Peak

Speaker 2 of 6
* Elizabeth Murphy, NHLBI, National Institutes of Health, USA

Wednesday, February 06 | 5:00PM - 7:00PM
Emerging Technologies to Characterize Mitochondrial and Meta
bolic Functioning

Room: Grays Peak

Speaker 3 of 6
Robert S. Balaban, NHLBI, National Institutes of Health, USA
Systems Biology of the Mitochondria Coordinated Moldulation of Complex Activity

Wednesday, February 06 | 5:00PM - 7:00PM
Emerging Technologies to Characterize Mitochondrial and Meta
bolic Functioning

Room: Grays Peak

Speaker 4 of 6
Peipei Ping, University of California, Los Angeles, USA
Large-Scale Proteomics Characterization of Cardiac Mitochondria: Molecular Function and Dynamics

Wednesday, February 06 | 5:00PM - 7:00PM
Emerging Technologies to Characterize Mitochondrial and Meta
bolic Functioning

Room: Grays Peak

Speaker 5 of 6
Christopher B. Newgard, Duke University Medical Center, USA
Metabolomics Applied to Mitochondrial Dysfunction in Metabolic Diseases

Wednesday, February 06 | 5:00PM - 7:00PM
Emerging Technologies to Characterize Mitochondrial and Meta
bolic Functioning

Room: Grays Peak

Speaker 6 of 6
Miguel A. Aon, Johns Hopkins University, USA
Short Talk: Metabolomics Unveils the Adverse Metabolic Remodeling Elicited by Hyperglycemia and Mitochondrial Dysfunction, and its Relief by Palmitate in T2DM Heart

Wednesday, February 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Wednesday, February 06 | 7:30PM - 10:00PM
Poster Session 3
Room: Shavano/Torreys


Thursday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Thursday, February 07 | 8:00AM - 11:00AM
Novel Programs Controlling Mitochondria and Metabolism
Room: Grays Peak

Speaker 1 of 7
* Martin E. Young, University of Alabama at Birmingham, USA

Thursday, February 07 | 8:00AM - 11:00AM
Novel Programs Controlling Mitochondria and Metabolism
Room: Grays Peak

Speaker 2 of 7
* Peter A. Crawford, University of Minnesota, USA

Thursday, February 07 | 8:00AM - 11:00AM
Novel Programs Controlling Mitochondria and Metabolism
Room: Grays Peak

Speaker 3 of 7
Jared Rutter, University of Utah, USA
Mitochondrial Pyruvate Metabolism and Human Disease

Thursday, February 07 | 8:00AM - 11:00AM
Novel Programs Controlling Mitochondria and Metabolism
Room: Grays Peak

Speaker 4 of 7
Christine Des Rosiers, Montreal Heart Institute (MHI), Canada
Metabolomics: What Have We Learned from Heart Failure Patients?

Thursday, February 07 | 8:00AM - 11:00AM
Novel Programs Controlling Mitochondria and Metabolism
Room: Grays Peak

Speaker 5 of 7
Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
Mitochondrial Function and Aging

Thursday, February 07 | 8:00AM - 11:00AM
Novel Programs Controlling Mitochondria and Metabolism
Room: Grays Peak

Speaker 6 of 7
Thomas Langer, CECAD Research Center, Germany
Mitochondrial Quality Control and Phospholipid Metabolism

Thursday, February 07 | 8:00AM - 11:00AM
Novel Programs Controlling Mitochondria and Metabolism
Room: Grays Peak

Speaker 7 of 7
Catherine Le, Colorado State University, USA
Short Talk: Integration of Respirometry and Metabo-Proteomic Profiling Reveal an Unexpected Mechanism of Cardiac Mitochondrial Dysfunction in Taz-Deficient Mice

Thursday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 07 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Thursday, February 07 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 07 | 5:00PM - 7:00PM
Clinical Studies to Advance Biological Insight and Therapeut
ic Targets

Room: Grays Peak

Speaker 1 of 6
* Roberta A. Gottlieb, Cedars-Sinai Medical Center, USA

Thursday, February 07 | 5:00PM - 7:00PM
Clinical Studies to Advance Biological Insight and Therapeut
ic Targets

Room: Grays Peak

Speaker 2 of 6
* † Seigo Izumo, Takeda Pharmaceutical Company, Japan

Thursday, February 07 | 5:00PM - 7:00PM
Clinical Studies to Advance Biological Insight and Therapeut
ic Targets

Room: Grays Peak

Speaker 3 of 6
Lawrence H. Young, Yale University, USA
AMPK Regulates Mitochondrial Function during Myocardial Ischemia-Reperfusion

Thursday, February 07 | 5:00PM - 7:00PM
Clinical Studies to Advance Biological Insight and Therapeut
ic Targets

Room: Grays Peak

Speaker 4 of 6
Patrick Schrauwen, Maastricht University, Netherlands
Lipotoxicity, Mitochondria and Cardiac Function: Insight from Human Clinical Intervention Studies

Thursday, February 07 | 5:00PM - 7:00PM
Clinical Studies to Advance Biological Insight and Therapeut
ic Targets

Room: Grays Peak

Speaker 5 of 6
Anthony J. Muslin, Tectonic Therapeutic, Inc., USA
Akt2 Regulates Cardiac Structure and Function

Thursday, February 07 | 5:00PM - 7:00PM
Clinical Studies to Advance Biological Insight and Therapeut
ic Targets

Room: Grays Peak

Speaker 6 of 6
Yan Liu, Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: Discovering Cardioprotective Drugs with Zebrafish

Thursday, February 07 | 7:00PM - 7:15PM
Closing Remarks
Room: Grays Peak

Speaker 1 of 2
Michael N. Sack, NHLBI, National Institutes of Health, USA

Thursday, February 07 | 7:00PM - 7:15PM
Closing Remarks
Room: Grays Peak

Speaker 2 of 2
Roberta A. Gottlieb, Cedars-Sinai Medical Center, USA

Thursday, February 07 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Thursday, February 07 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys


Thursday, February 07 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Friday, February 08 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.