Web Desc
Lung Development, Cancer and Disease
Organizer(s): Brigid L.M. Hogan, Jeffrey A. Whitsett and Christine Kim Garcia
Date: February 05 - 10, 2013
Location: Sagebrush Inn & Suites, Taos, NM, USA
Sponsored by Infinity Pharmaceuticals and Pfizer Inc.
Summary of Meeting:
Respiratory pathologies, including asthma, chronic obstructive pulmonary disease, lung cancer and fibrosis, impose significant healthcare burdens on populations throughout the world. The goal of this meeting is to bring together basic and clinical scientists studying a range of topics including: mechanisms underlying the embryonic development and maturation of the normal lung, endogenous stem cells and their role in repair and regeneration, the genetics of human lung diseases, and the cells-of-origin and progression of cancer and fibrosis. The format will be designed to promote critical discussion and debate and collaboration among participants who do not traditionally go to the same scientific meetings. The emphasis will be to stimulate new ways of thinking about old problems and new ideas about potential therapies. A common theme will be the question of how the different cell types in the lung – the epithelium, vasculature, mesenchyme and immune cells – interact during development and how these mechanisms may be disrupted or re-activated in association with disease initiation and progression. Based on participant feedback from the 2011 Keystone Symposia meeting on Lung Development and Repair, there will be more workshop-style sessions in which specific technical issues will be critically discussed, and junior clinician scientists and trainees can learn about different models of lung development, lung injury and repair, and lung stem cells. Other sessions will address emerging issues in lung biology, including new cellular therapies, the effect of environmental factors and the identification of genes and pathways associated with rare lung diseases that have the potential to throw light on broader issues of lung biology.
Scholarship Deadline: October 8 2012
Discounted Abstract Deadline: October 8 2012
Abstract Deadline: November 5 2012
Discounted Registration Deadline: December 5 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Infinity PharmaceuticalsPfizer Inc.
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.March of Dimes Foundation Grant No. 4-FY12-556
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

FibroGen Incorporated
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 05 | 4:00PM - 8:00PM
Arrival and Registration
Room: Chamisa Lobby


Wednesday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, February 06 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 3
* Brigid L. M. Hogan, Duke University Medical Center, USA

Wednesday, February 06 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Chamisa Ballroom 1

Speaker 2 of 3
* Christine Kim Garcia, Columbia University Medical Center, USA

Wednesday, February 06 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Chamisa Ballroom 1

Speaker 3 of 3
Anton J. M. Berns, Netherlands Cancer Institute, Netherlands
Mouse Models for Small Cell and Non-Small Cell Lung Cancer

Wednesday, February 06 | 9:00AM - 12:00PM
Lung Development
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Brigid L. M. Hogan, Duke University Medical Center, USA

Wednesday, February 06 | 9:00AM - 12:00PM
Lung Development
Room: Chamisa Ballroom 1

Speaker 2 of 6
Mark A. Krasnow, Stanford University School of Medicine, USA
Genetic Dissection of Lung Development and Disease

Wednesday, February 06 | 9:00AM - 12:00PM
Lung Development
Room: Chamisa Ballroom 1

Speaker 3 of 6
James M. Wells, Cincinnati Children's Hospital Research Foundation, USA
Deriving Complex Endodermal Organ Tissues from Human Pluripotent Stem Cell for Disease Research

Wednesday, February 06 | 9:00AM - 12:00PM
Lung Development
Room: Chamisa Ballroom 1

Speaker 4 of 6
Xin Sun, University of California, San Diego, USA
Branching Morphogenesis of the Lung

Wednesday, February 06 | 9:00AM - 12:00PM
Lung Development
Room: Chamisa Ballroom 1

Speaker 5 of 6
Yi Wang, University of Pennsylvania, USA
Development and Regeneration of Sox2+ Endoderm Progenitors Is Regulated by a Hdac1/2-Bmp4/Rb1 Regulatory Pathway

Wednesday, February 06 | 9:00AM - 12:00PM
Lung Development
Room: Chamisa Ballroom 1

Speaker 6 of 6
Marie-Liesse Asselin-Labat, Walter and Eliza Hall Institute, Australia
Short Talk: LMO4 in the Lung: Roles in Development, Repair and Tumorigenesis

Wednesday, February 06 | 9:40AM - 10:00AM
Coffee Break
Room: Chamisa Lobby


Wednesday, February 06 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, February 06 | 12:00PM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, February 06 | 3:00PM - 4:30PM
Workshop 1: Lung Cell Replacement
Room: Chamisa Ballroom 1
Topics to include differentiation of iPSCs into lung endoderm and derivation of iPSCs from diseased lung, making artificial airways, and synthetic biopolymers as scaffolds for building new airways.
Speaker 1 of 4
* James M. Wells, Cincinnati Children's Hospital Research Foundation, USA

Wednesday, February 06 | 3:00PM - 4:30PM
Workshop 1: Lung Cell Replacement
Room: Chamisa Ballroom 1
Topics to include differentiation of iPSCs into lung endoderm and derivation of iPSCs from diseased lung, making artificial airways, and synthetic biopolymers as scaffolds for building new airways.
Speaker 2 of 4
Michael J. Riedel, STEMCELL Technologies, Canada
Highly Efficient Differentiation of Human Pluripotent Stem Cells to Definitive Endoderm Using a Novel Animal Component-Free Medium

Wednesday, February 06 | 3:00PM - 4:30PM
Workshop 1: Lung Cell Replacement
Room: Chamisa Ballroom 1
Topics to include differentiation of iPSCs into lung endoderm and derivation of iPSCs from diseased lung, making artificial airways, and synthetic biopolymers as scaffolds for building new airways.
Speaker 3 of 4
Christina Mauritz, Hannover Medical School, Germany
Dexamethasone Plus cAMP-Elevating Agents Support Airway Epithelial Differentiation of Embryonic and Induced Pluripotent Stem Cells

Wednesday, February 06 | 3:00PM - 4:30PM
Workshop 1: Lung Cell Replacement
Room: Chamisa Ballroom 1
Topics to include differentiation of iPSCs into lung endoderm and derivation of iPSCs from diseased lung, making artificial airways, and synthetic biopolymers as scaffolds for building new airways.
Speaker 4 of 4
Samuel J. Wadsworth, University of British Columbia, Canada
Bio-Airway Research Offering New Concepts in Health (BRONCH) Partnership – Building a Bio-Engineered Airway

Wednesday, February 06 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, February 06 | 5:00PM - 7:00PM
Specification, Differentiation and Patterning of Airway Epit
helial Cell Lineages

Room: Chamisa Ballroom 1

Speaker 1 of 5
* Mark A. Krasnow, Stanford University School of Medicine, USA

Wednesday, February 06 | 5:00PM - 7:00PM
Specification, Differentiation and Patterning of Airway Epit
helial Cell Lineages

Room: Chamisa Ballroom 1

Speaker 2 of 5
Mitsuru Morimoto, RIKEN, Center for Developmental Biology, Japan
Two Types of Notch Signaling Coordinate the Distribution of the Major Bronchial Clara, Ciliated and Neuroendocrine Cells

Wednesday, February 06 | 5:00PM - 7:00PM
Specification, Differentiation and Patterning of Airway Epit
helial Cell Lineages

Room: Chamisa Ballroom 1

Speaker 3 of 5
Eszter K. Vladar, Stanford University School of Medicine, USA
Mechanisms Regulating Epithelial Planar Cell Polarity in the Developing Lung

Wednesday, February 06 | 5:00PM - 7:00PM
Specification, Differentiation and Patterning of Airway Epit
helial Cell Lineages

Room: Chamisa Ballroom 1

Speaker 4 of 5
John F. Engelhardt, University of Iowa, USA
Development and Maintenance of the Submucosal Gland Stem/Progenitor Cell Niche

Wednesday, February 06 | 5:00PM - 7:00PM
Specification, Differentiation and Patterning of Airway Epit
helial Cell Lineages

Room: Chamisa Ballroom 1

Speaker 5 of 5
Nicholas Manzo, Duke University, USA
Short Talk: Epithelial-Stromal Interactions in the Adult Murine Lung

Wednesday, February 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Wednesday, February 06 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Thursday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, February 07 | 8:00AM - 11:15AM
Lung Cancer and COPD
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Tushar J. Desai, Stanford University, USA

Thursday, February 07 | 8:00AM - 11:15AM
Lung Cancer and COPD
Room: Chamisa Ballroom 1

Speaker 2 of 6
David M. Ornitz, Washington University School of Medicine, USA
Multiple Roles for FGF9 in Lung Development and the Pathogenesis of Cancer

Thursday, February 07 | 8:00AM - 11:15AM
Lung Cancer and COPD
Room: Chamisa Ballroom 1

Speaker 3 of 6
Christin S. Kuo, Stanford University, USA
Cellular and Genetic Dissection of Pulmonary Neuroepithelial Body (NEB) Development

Thursday, February 07 | 8:00AM - 11:15AM
Lung Cancer and COPD
Room: Chamisa Ballroom 1

Speaker 4 of 6
Mary Armanios, Johns Hopkins University School of Medicine, USA
Telomerase and its Role in Emphysema-Fibrosis Pathogenesis

Thursday, February 07 | 8:00AM - 11:15AM
Lung Cancer and COPD
Room: Chamisa Ballroom 1

Speaker 5 of 6
Avrum Spira, Boston University, USA
The Airway Field of Injury in Lung Cancer and COPD

Thursday, February 07 | 8:00AM - 11:15AM
Lung Cancer and COPD
Room: Chamisa Ballroom 1

Speaker 6 of 6
Jichao Chen, University of Texas MD Anderson Cancer Center, USA
Short Talk: Sox-Dependent Kras Signaling Network in Lung Development and Cancer

Thursday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, February 07 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, February 07 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Thursday, February 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Thursday, February 07 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Thursday, February 07 | 5:00PM - 7:15PM
Lung Mesodermal Lineages and Vascularization
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Xin Sun, University of California, San Diego, USA

Thursday, February 07 | 5:00PM - 7:15PM
Lung Mesodermal Lineages and Vascularization
Room: Chamisa Ballroom 1

Speaker 2 of 6
Anne-Karina T. Perl, Cincinnati Children's Hospital, USA
Regulation of Contractile and Synthetic Fibroblast Phenotypes during Realveolarization

Thursday, February 07 | 5:00PM - 7:15PM
Lung Mesodermal Lineages and Vascularization
Room: Chamisa Ballroom 1

Speaker 3 of 6
Bruce C. Trapnell, University of Cincinnati College of Medicine, USA
GM-CSF, Lung Macrophages, and Pulmonary Alveolar Proteinosis

Thursday, February 07 | 5:00PM - 7:15PM
Lung Mesodermal Lineages and Vascularization
Room: Chamisa Ballroom 1

Speaker 4 of 6
Tien Peng, University of Pennsylvania, USA
Multipotent Wnt2+/Gli1+ Posterior Second Heart Field Progenitors Give Rise to the Pulmonary Vasculature through a Hedgehog Mediated Pathway

Thursday, February 07 | 5:00PM - 7:15PM
Lung Mesodermal Lineages and Vascularization
Room: Chamisa Ballroom 1

Speaker 5 of 6
Joo-Hyeon Lee, Children's Hospital Boston, USA
Short Talk: TSP-1 Mediated TGF-beta Signaling from Endothelial Cells Drives Lung Stem Cell Differentiation

Thursday, February 07 | 5:00PM - 7:15PM
Lung Mesodermal Lineages and Vascularization
Room: Chamisa Ballroom 1

Speaker 6 of 6
Trudy G. Oliver, Huntsman Cancer Institute, USA
Short Talk: Using Mouse Models of Lung Cancer to Identify Pathways Involved in Chemotherapy Resistance

Thursday, February 07 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Thursday, February 07 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Friday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Friday, February 08 | 8:00AM - 11:00AM
Alveolar Development, Vascular Remodeling and Alveolar Disea
se

Room: Chamisa Ballroom 1

Speaker 1 of 5
* Lynn Y. Sakai, Shriner's Hospital and Oregon Health & Science University, USA

Friday, February 08 | 8:00AM - 11:00AM
Alveolar Development, Vascular Remodeling and Alveolar Disea
se

Room: Chamisa Ballroom 1

Speaker 2 of 5
Tushar J. Desai, Stanford University, USA
Alveolar Epithelial Progenitor Cells in Maintenance and Disease

Friday, February 08 | 8:00AM - 11:00AM
Alveolar Development, Vascular Remodeling and Alveolar Disea
se

Room: Chamisa Ballroom 1

Speaker 3 of 5
Daniel B. Rifkin, New York University, USA
The Role of TGF-beta Binding Proteins in Lung Development

Friday, February 08 | 8:00AM - 11:00AM
Alveolar Development, Vascular Remodeling and Alveolar Disea
se

Room: Chamisa Ballroom 1

Speaker 4 of 5
Mark R. Looney, University of California, San Francisco, USA
Real-Time Imaging of Cell Trafficking in Lung Alveoli

Friday, February 08 | 8:00AM - 11:00AM
Alveolar Development, Vascular Remodeling and Alveolar Disea
se

Room: Chamisa Ballroom 1

Speaker 5 of 5
Vladimir V. Kalinichenko, Cincinnati Children's Hospital Medical Center, USA
Transcriptional Regulation of Endothelial Cells during Lung Development and Alveolar Disease

Friday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Friday, February 08 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Friday, February 08 | 3:00PM - 4:00PM
Workshop 2: Models of Injury and Repair in the Lung: Basic S
cience and Novel Therapeutics
Room: Chamisa Ballroom 1
Topics to include chemical induced injury and screens for small molecules promoting repair.
Speaker 1 of 4
* Aron B. Jaffe, Third Rock Ventures, USA

Friday, February 08 | 3:00PM - 4:00PM
Workshop 2: Models of Injury and Repair in the Lung: Basic S
cience and Novel Therapeutics
Room: Chamisa Ballroom 1
Topics to include chemical induced injury and screens for small molecules promoting repair.
Speaker 2 of 4
Jenni S. P. Lahtela, Institution for Molecular Medicine Finland, Finland
Identification of EPHA3 as a Candidate Tumor Suppressor in a Screen for Cellular Senescence

Friday, February 08 | 3:00PM - 4:00PM
Workshop 2: Models of Injury and Repair in the Lung: Basic S
cience and Novel Therapeutics
Room: Chamisa Ballroom 1
Topics to include chemical induced injury and screens for small molecules promoting repair.
Speaker 3 of 4
Geraldine A. Strasser, Genentech, Inc., USA
Chemical Genetics ex vivo Reveals that Lkb1 Regulates Lung Branching and Pancreatic Morhpogenesis along AMPK-Dependent and -Independent Pathways

Friday, February 08 | 3:00PM - 4:00PM
Workshop 2: Models of Injury and Repair in the Lung: Basic S
cience and Novel Therapeutics
Room: Chamisa Ballroom 1
Topics to include chemical induced injury and screens for small molecules promoting repair.
Speaker 4 of 4
Kimberly Walter, Genentech, USA
Quantitative DNA Methylation Analysis Reveals Consistent Epigenetic Changes during an Induced Mesenchymal Transition of Lung Epithelial Cells

Friday, February 08 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Friday, February 08 | 5:00PM - 7:15PM
Lung Progenitor Cells and Lung Disease
Room: Chamisa Ballroom 1

Speaker 1 of 6
* John F. Engelhardt, University of Iowa, USA

Friday, February 08 | 5:00PM - 7:15PM
Lung Progenitor Cells and Lung Disease
Room: Chamisa Ballroom 1

Speaker 2 of 6
Brigid L. M. Hogan, Duke University Medical Center, USA
Stem Cells of the Adult Lung

Friday, February 08 | 5:00PM - 7:15PM
Lung Progenitor Cells and Lung Disease
Room: Chamisa Ballroom 1

Speaker 3 of 6
Frank McKeon, The Jackson Laboratory for Genomic Medicine, USA
Regiospecific Stem Cells of the Human Upper and Lower Airways and their Role in Lung Regeneration

Friday, February 08 | 5:00PM - 7:15PM
Lung Progenitor Cells and Lung Disease
Room: Chamisa Ballroom 1

Speaker 4 of 6
Aron B. Jaffe, Third Rock Ventures, USA
Regulation of Cell Fate Decisions in the Airway

Friday, February 08 | 5:00PM - 7:15PM
Lung Progenitor Cells and Lung Disease
Room: Chamisa Ballroom 1

Speaker 5 of 6
Jayakar V. Nayak, Stanford University School of Medicine, USA
Short Talk: Basal Progenitor Cell Dynamics of the Nasal Cavity and Sinuses

Friday, February 08 | 5:00PM - 7:15PM
Lung Progenitor Cells and Lung Disease
Room: Chamisa Ballroom 1

Speaker 6 of 6
Matthew Walters, Weill Cornell Medical College, USA
Short Talk: Endothelial Expressed Matrix Metallopeptidase 14 Is Required for Endothelial Dependent Growth Support of Human Airway Basal Cells

Friday, February 08 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Saturday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Saturday, February 09 | 8:00AM - 11:00AM
Lung and Tissue Fibrosis
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Mary Armanios, Johns Hopkins University School of Medicine, USA

Saturday, February 09 | 8:00AM - 11:00AM
Lung and Tissue Fibrosis
Room: Chamisa Ballroom 1

Speaker 2 of 6
Christine Kim Garcia, Columbia University Medical Center, USA
Genetics and Pathways of Lung Fibrosis

Saturday, February 09 | 8:00AM - 11:00AM
Lung and Tissue Fibrosis
Room: Chamisa Ballroom 1

Speaker 3 of 6
Andreas Günther, University Hospital Giessen, Germany
Signaling Mechanisms in Lung Fibrosis

Saturday, February 09 | 8:00AM - 11:00AM
Lung and Tissue Fibrosis
Room: Chamisa Ballroom 1

Speaker 4 of 6
Nick Hutchison, University of Washington, USA
Pericytes in Tissue Fibrosis and Disease

Saturday, February 09 | 8:00AM - 11:00AM
Lung and Tissue Fibrosis
Room: Chamisa Ballroom 1

Speaker 5 of 6
Kenneth E. Lipson, Fibrogen, USA
Inhibition of CTGF Prevents and Reverses Lung Remodeling in a Mouse Model of Radiation-Induced Fibrosis

Saturday, February 09 | 8:00AM - 11:00AM
Lung and Tissue Fibrosis
Room: Chamisa Ballroom 1

Speaker 6 of 6
Ari Jon Arason, University of Iceland, Iceland
Short Talk: Human Bronchial Basal Epithelial Cells as Candidate EMT Precursors in Idiopathic Pulmonary Fibrosis

Saturday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Saturday, February 09 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Saturday, February 09 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Saturday, February 09 | 5:00PM - 7:00PM
New Insights from Genetic Analysis of Rare Lung Diseases
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Christine Kim Garcia, Columbia University Medical Center, USA

Saturday, February 09 | 5:00PM - 7:00PM
New Insights from Genetic Analysis of Rare Lung Diseases
Room: Chamisa Ballroom 1

Speaker 2 of 4
Enid R. Neptune, Johns Hopkins University, USA
The Active Matrix in Airspace Disorders

Saturday, February 09 | 5:00PM - 7:00PM
New Insights from Genetic Analysis of Rare Lung Diseases
Room: Chamisa Ballroom 1

Speaker 3 of 4
Rachael M. Andrie, Oregon Health & Science University, USA
Emphysema in a Mouse Model of Marfan Syndrome

Saturday, February 09 | 5:00PM - 7:00PM
New Insights from Genetic Analysis of Rare Lung Diseases
Room: Chamisa Ballroom 1

Speaker 4 of 4
Esteban C. Dell'Angelica, University of California, Los Angeles, USA
Molecular Basis of Hermansky-Pudlak Syndrome

Saturday, February 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Saturday, February 09 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Saturday, February 09 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Sunday, February 10 | 10:25AM - 10:25AM
Departure


*Session Chair.