Web Desc
Autophagy, Inflammation and Immunity
Organizer(s): Herbert (Skip) W. Virgin, Beth Levine and Gökhan S. Hotamisligil
Date: February 17 - 22, 2013
Location: Fairmont The Queen Elizabeth, Montreal, QC, Canada
Sponsored by AbbVie Inc., Cell Research, EMD Millipore, Shire Human Genetic Therapies and Vertex Pharmaceuticals Incorporated
Summary of Meeting:
Autophagy is a lysosomal degradation pathway by which eukaryotic cells break down their own components to adapt to nutrient deprivation. In multicellular organisms, autophagy and autophagy proteins also play a key role in the orchestration of diverse aspects of cellular and organismal responses to multiple dangerous stimuli, including infection. Thus, autophagy and autophagy proteins represent a key nexus within the cell through which multiple cellular and organismal stresses are integrated. This emerging understanding has led to exciting recent advances that, together, begin to paint a picture of how autophagy and autophagy proteins are involved in multiple diseases. Of particular interest, recent studies reveal a crucial role for autophagy pathways and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune, and inflammatory diseases. The time is therefore ripe for a Keystone Symposia meeting that brings together researchers from a variety of fields to focus on emerging themes and concepts in 'Autophagy, Inflammation, and Immunity'. Key advances in this area include the identification of signaling pathways that regulate autophagy, inflammation, and immunity and the finding that inflammation, immunity and autophagy are tightly, and reciprocally, intertwined. The goal of this meeting is to relate the cell biology and signaling pathways that regulate autophagy and autophagy proteins to fundamental aspects of immunity and inflammation, as well as to diseases associated with alterations in these processes such as autoimmunity, infection, cancer, diabetes, the metabolic syndrome, and cardiovascular disease.
Scholarship Deadline: October 16 2012
Discounted Abstract Deadline: October 16 2012
Abstract Deadline: November 15 2012
Discounted Registration Deadline: December 13 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AbbVie Inc.Cell ResearchEMD MilliporeShire Human Genetic TherapiesVertex Pharmaceuticals Incorporated
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Tourisme Montréal
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Tokyo Metropolitan Institute of Medical Science
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-04
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 17 | 4:00PM - 8:00PM
Arrival and Registration
Room: Alcove


Monday, February 18 | 7:30AM - 8:30AM
Breakfast
Room: Hochelaga 1-3


Monday, February 18 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Le Grand Salon

Speaker 1 of 1
Douglas R. Green, St. Jude Children's Research Hospital, USA
Autophagy and the Immunological Impact of Dying Cells

Monday, February 18 | 9:30AM - 11:45AM
Mechanisms of Autophagy
Room: Le Grand Salon

Speaker 1 of 5
* Beth Levine, University of Texas Southwestern Medical Center, USA

Monday, February 18 | 9:30AM - 11:45AM
Mechanisms of Autophagy
Room: Le Grand Salon

Speaker 2 of 5
Noboru Mizushima, University of Tokyo, Japan
Molecular Mechanisms of Formation of the Autophagosome and its Fusion with the Lysosome

Monday, February 18 | 9:30AM - 11:45AM
Mechanisms of Autophagy
Room: Le Grand Salon

Speaker 3 of 5
Sharon A. Tooze, Francis Crick Institute, UK
Initiation of the Autophagosome Membrane

Monday, February 18 | 9:30AM - 11:45AM
Mechanisms of Autophagy
Room: Le Grand Salon

Speaker 4 of 5
Mark J. Daly, Harvard Medical School, USA
Autophagy Genes in Human Disease

Monday, February 18 | 9:30AM - 11:45AM
Mechanisms of Autophagy
Room: Le Grand Salon

Speaker 5 of 5
Takanori Otomo, The Scripps Research Institute, USA
Short Talk: Structure of the Human ATG12~ATG5 Conjugate Required for LC3 Lipidation in Autophagy

Monday, February 18 | 10:10AM - 10:30AM
Coffee Break
Room: Hochelaga 1-3


Monday, February 18 | 11:45AM - 1:00PM
Poster Setup
Room: Hochelaga 1-3


Monday, February 18 | 11:45AM - 4:30PM
On Own for Lunch and Recreation


Monday, February 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Hochelaga 1-3


Monday, February 18 | 2:30PM - 4:30PM
Workshop
Room: Le Grand Salon

Speaker 1 of 10
* Ken H. Cadwell, New York University School of Medicine, USA

Monday, February 18 | 2:30PM - 4:30PM
Workshop
Room: Le Grand Salon

Speaker 2 of 10
* Eun-Kyeong Jo, Chungnam National University, South Korea

Monday, February 18 | 2:30PM - 4:30PM
Workshop
Room: Le Grand Salon

Speaker 3 of 10
Jamaal Benjamin, University of Texas Southwestern Medical Center, USA
Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine

Monday, February 18 | 2:30PM - 4:30PM
Workshop
Room: Le Grand Salon

Speaker 4 of 10
Juliane Becher, Santa Lucia Foundation, Italy
AMBRA1 is Upregulated during T Cell Stimulation to Avoid Excessive Proliferation and Stabilizes the Regulatory T Cell Phenotype

Monday, February 18 | 2:30PM - 4:30PM
Workshop
Room: Le Grand Salon

Speaker 5 of 10
Tiffany Horng, ShanghaiTech University, China
A Critical Role for Calcium Mobilization in Activation of the NLRP3 Inflammasome

Monday, February 18 | 2:30PM - 4:30PM
Workshop
Room: Le Grand Salon

Speaker 6 of 10
Rhea M. Sumpter, Jr., University of Texas Southwestern Medical Center, USA
FANCC Is a Novel Selective Autophagy Factor

Monday, February 18 | 2:30PM - 4:30PM
Workshop
Room: Le Grand Salon

Speaker 7 of 10
Audrey Esclatine, INSERM, France
A Viral Protein Represses Autophagy by Interacting with the Protein Kinase PKR

Monday, February 18 | 2:30PM - 4:30PM
Workshop
Room: Le Grand Salon

Speaker 8 of 10
You-Wen He, Duke University Medical Center, USA
Inositol Phosphatases and Class I PI3K Synergize to Induce Autophagy in T Cells

Monday, February 18 | 2:30PM - 4:30PM
Workshop
Room: Le Grand Salon

Speaker 9 of 10
Jane Symington, Washington University in St. Louis, USA
ATG16L1 Regulates Host Defense to Uropathogenic Escherichia coli Infection by Controlling Macrophage-Mediated Bacterial Clearance

Monday, February 18 | 2:30PM - 4:30PM
Workshop
Room: Le Grand Salon

Speaker 10 of 10
Ingo Schmitz, Otto von Guericke University Magdeburg, Germany
The Gadd45beta-MEKK4-p38 Pathway Mediates Phosphorylation of Atg5 and Autophagy Inhibition

Monday, February 18 | 4:30PM - 5:00PM
Coffee Available
Room: Hochelaga 1-3


Monday, February 18 | 5:00PM - 7:00PM
Selective Autophagy and Infection
Room: Le Grand Salon

Speaker 1 of 5
* Sharon A. Tooze, Francis Crick Institute, UK

Monday, February 18 | 5:00PM - 7:00PM
Selective Autophagy and Infection
Room: Le Grand Salon

Speaker 2 of 5
Michael J. Ragusa, Dartmouth College, USA
Short Talk: Architecture of the Atg17 Complex as a Scaffold for Autophagosome Biogenesis

Monday, February 18 | 5:00PM - 7:00PM
Selective Autophagy and Infection
Room: Le Grand Salon

Speaker 3 of 5
Ivan Dikic, Goethe University Medical School, Germany
Structure-Function Analysis of Selective Autophagy Receptors

Monday, February 18 | 5:00PM - 7:00PM
Selective Autophagy and Infection
Room: Le Grand Salon

Speaker 4 of 5
Jeffery S. Cox, University of California, Berkeley, USA
The Ubiquitin Ligase PARKIN Is Required for Autophagy and Host Resistance to Intracellular Pathogens

Monday, February 18 | 5:00PM - 7:00PM
Selective Autophagy and Infection
Room: Le Grand Salon

Speaker 5 of 5
Yuuki Fujiwara, National Institute of Neuroscience, NCNP, Japan
Short Talk: A Novel Type of Autophagy that Targets RNA

Monday, February 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Hochelaga 1-3


Monday, February 18 | 7:30PM - 10:00PM
Poster Session 1
Room: Hochelaga 1-3


Tuesday, February 19 | 7:30AM - 8:30AM
Breakfast
Room: Hochelaga 1-3


Tuesday, February 19 | 8:00AM - 8:30AM
Poster Setup
Room: Hochelaga 1-3


Tuesday, February 19 | 8:30AM - 5:00PM
Poster Viewing
Room: Hochelaga 1-3


Tuesday, February 19 | 8:30AM - 11:45AM
Autophagy and Infection
Room: Le Grand Salon

Speaker 1 of 7
* Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA

Tuesday, February 19 | 8:30AM - 11:45AM
Autophagy and Infection
Room: Le Grand Salon

Speaker 2 of 7
Pascale Cossart, Institut Pasteur, France
Autophagy and the Cytoskeleton: Links Revealed by Cytosolic Bacteria

Tuesday, February 19 | 8:30AM - 11:45AM
Autophagy and Infection
Room: Le Grand Salon

Speaker 3 of 7
Robert L. Modlin, University of California, Los Angeles, USA
Vitamin D, Autophagy and Tuberculosis

Tuesday, February 19 | 8:30AM - 11:45AM
Autophagy and Infection
Room: Le Grand Salon

Speaker 4 of 7
Beth Levine, University of Texas Southwestern Medical Center, USA
A Candidate Therapeutic Autophagy-Inducing Peptide for Viral Infections

Tuesday, February 19 | 8:30AM - 11:45AM
Autophagy and Infection
Room: Le Grand Salon

Speaker 5 of 7
Fulvio Reggiori, University Medical Centre Groningen, Netherlands
Coronaviruses Hijack LC3-I-Positive EDEMosome Membranes for Replication

Tuesday, February 19 | 8:30AM - 11:45AM
Autophagy and Infection
Room: Le Grand Salon

Speaker 6 of 7
Augustine H. Choy, Yale University, USA
Short Talk: The Legionella Effector RavZ Inhibits Host Autophagy through Irreversible Atg8 Deconjugation

Tuesday, February 19 | 8:30AM - 11:45AM
Autophagy and Infection
Room: Le Grand Salon

Speaker 7 of 7
Eun-Kyeong Jo, Chungnam National University, South Korea
Short Talk: AMP-Activated Protein Kinase Activator AICAR Activates Innate Host Defense through Antibacterial Autophagy and Mitochondrial Biogenesis

Tuesday, February 19 | 9:50AM - 10:10AM
Coffee Break
Room: Hochelaga 1-3


Tuesday, February 19 | 11:45AM - 12:30PM
Lunch
Room: Hochelaga 1-3


Tuesday, February 19 | 12:30PM - 3:00PM
Poster Session 2
Room: Hochelaga 1-3


Tuesday, February 19 | 3:00PM - 3:30PM
Coffee Available
Room: Hochelaga 1-3


Tuesday, February 19 | 3:30PM - 5:30PM
Autophagy and Immunity
Room: Le Grand Salon

Speaker 1 of 5
* Augustine Choi, Harvard Medical School, USA

Tuesday, February 19 | 3:30PM - 5:30PM
Autophagy and Immunity
Room: Le Grand Salon

Speaker 2 of 5
Herbert (Skip) W. Virgin, Vir Biotechnology, USA
Autophagy Proteins and Macrophage-Based Immunity to Infection

Tuesday, February 19 | 3:30PM - 5:30PM
Autophagy and Immunity
Room: Le Grand Salon

Speaker 3 of 5
Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy Protects Against Active Tuberculosis by Suppressing Bacterial Burden and Inflammation

Tuesday, February 19 | 3:30PM - 5:30PM
Autophagy and Immunity
Room: Le Grand Salon

Speaker 4 of 5
Tatsuya Saitoh, Osaka University, Japan
Regulation of Inflammatory Innate Immune Response by Autophagy-Related Protein

Tuesday, February 19 | 3:30PM - 5:30PM
Autophagy and Immunity
Room: Le Grand Salon

Speaker 5 of 5
Amanda Marchiando, New York University School of Medicine, USA
Short Talk: Atg16L1 Mutation Protects Against Bacterial Gastroenteritis

Tuesday, February 19 | 5:30PM - 5:30PM
On Own for Dinner


Wednesday, February 20 | 7:30AM - 8:30AM
Breakfast
Room: Hochelaga 1-3


Wednesday, February 20 | 8:30AM - 11:45AM
Autophagy and the Inflammasome
Room: Le Grand Salon

Speaker 1 of 7
* Lora V. Hooper, University of Texas Southwestern Medical Center, USA

Wednesday, February 20 | 8:30AM - 11:45AM
Autophagy and the Inflammasome
Room: Le Grand Salon

Speaker 2 of 7
Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Metabolic Inflammasome and Mechanisms of Immunometabolic Integration

Wednesday, February 20 | 8:30AM - 11:45AM
Autophagy and the Inflammasome
Room: Le Grand Salon

Speaker 3 of 7
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs, Inflammasome and Autophagy

Wednesday, February 20 | 8:30AM - 11:45AM
Autophagy and the Inflammasome
Room: Le Grand Salon

Speaker 4 of 7
Augustine Choi, Harvard Medical School, USA
Mitophagy, Mitochondria and the Inflammasome

Wednesday, February 20 | 8:30AM - 11:45AM
Autophagy and the Inflammasome
Room: Le Grand Salon

Speaker 5 of 7
Nobuhiko Kayagaki, Genentech, Inc., USA
The Non-Canonical Inflammasome and Caspase 11

Wednesday, February 20 | 8:30AM - 11:45AM
Autophagy and the Inflammasome
Room: Le Grand Salon

Speaker 6 of 7
Catherine Gidley Weindel, Tufts University Sackler School of Biomedical Sciences, USA
Short Talk: Autophagy: A Dichotomous Player in TLR7-Mediated Autoimmunity

Wednesday, February 20 | 8:30AM - 11:45AM
Autophagy and the Inflammasome
Room: Le Grand Salon

Speaker 7 of 7
Miguel A. Sanjuan, Bristol-Myers Squibb Co., USA
Short Talk: LC3-Associated Phagocytosis Mediates IFN-alpha Secretion in Response to DNA-Immune Complexes

Wednesday, February 20 | 9:50AM - 10:10AM
Coffee Break
Room: Hochelaga 1-3


Wednesday, February 20 | 11:45AM - 1:00PM
Poster Setup
Room: Hochelaga 1-3


Wednesday, February 20 | 11:45AM - 4:30PM
On Own for Lunch and Recreation


Wednesday, February 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Hochelaga 1-3


Wednesday, February 20 | 4:30PM - 5:00PM
Coffee Available
Room: Hochelaga 1-3


Wednesday, February 20 | 5:00PM - 7:00PM
Autophagy and Inflammatory Signaling
Room: Le Grand Salon

Speaker 1 of 5
* Eileen P. White, Rutgers Cancer Institute of New Jersey, USA

Wednesday, February 20 | 5:00PM - 7:00PM
Autophagy and Inflammatory Signaling
Room: Le Grand Salon

Speaker 2 of 5
Masaaki Komatsu, Juntendo University School of Medicine, Japan
Selective Autophagy Is Coupled to Nrf2-Keap1 Pathway

Wednesday, February 20 | 5:00PM - 7:00PM
Autophagy and Inflammatory Signaling
Room: Le Grand Salon

Speaker 3 of 5
Jorge Moscat, Sanford Burnham Prebys Institute, USA
p62: A Multifunctional Signaling Molecule in Inflammation and Metabolism

Wednesday, February 20 | 5:00PM - 7:00PM
Autophagy and Inflammatory Signaling
Room: Le Grand Salon

Speaker 4 of 5
Sergio Grinstein, Hospital for Sick Children, Canada
Phospholipids Mediate Immune Surveillance by Macrophages and Dendritic Cells

Wednesday, February 20 | 5:00PM - 7:00PM
Autophagy and Inflammatory Signaling
Room: Le Grand Salon

Speaker 5 of 5
Christina Bell, Université de Montréal, Canada
Short Talk: Quantitative Proteomics Reveals the Specific Autophagic Elimination of Mitochondria in TNF-alpha Activated Macrophages

Wednesday, February 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Hochelaga 1-3


Wednesday, February 20 | 7:30PM - 10:00PM
Poster Session 3
Room: Hochelaga 1-3


Thursday, February 21 | 7:30AM - 8:30AM
Breakfast
Room: Hochelaga 1-3


Thursday, February 21 | 8:30AM - 11:45AM
Autophagy in Metabolic and Inflammatory Disease
Room: Le Grand Salon

Speaker 1 of 7
* Vojo Deretic, University of New Mexico Health Sciences Center, USA

Thursday, February 21 | 8:30AM - 11:45AM
Autophagy in Metabolic and Inflammatory Disease
Room: Le Grand Salon

Speaker 2 of 7
Mark J. Czaja, Albert Einstein College of Medicine, USA
Autophagy and Lipid Metabolism

Thursday, February 21 | 8:30AM - 11:45AM
Autophagy in Metabolic and Inflammatory Disease
Room: Le Grand Salon

Speaker 3 of 7
Clay F. Semenkovich, Washington University School of Medicine, USA
Autophagy, Atherosclerosis, and the Metabolic Syndrome

Thursday, February 21 | 8:30AM - 11:45AM
Autophagy in Metabolic and Inflammatory Disease
Room: Le Grand Salon

Speaker 4 of 7
Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Intestinal Epithelial Cell Autophagy and the Microbiota

Thursday, February 21 | 8:30AM - 11:45AM
Autophagy in Metabolic and Inflammatory Disease
Room: Le Grand Salon

Speaker 5 of 7
Thaddeus S. Stappenbeck, Cleveland Clinic, USA
Autophagy Proteins and Regulation of Intestinal Homeostasis

Thursday, February 21 | 8:30AM - 11:45AM
Autophagy in Metabolic and Inflammatory Disease
Room: Le Grand Salon

Speaker 6 of 7
Assaf Rudich, Ben-Gurion University, Israel
Short Talk: Transcriptional Basis for Inflammatory Activation of Adipose Tissue Autophagy in Obesity

Thursday, February 21 | 8:30AM - 11:45AM
Autophagy in Metabolic and Inflammatory Disease
Room: Le Grand Salon

Speaker 7 of 7
Donna M. Conlon, Columbia University, USA
Short Talk: Inhibition of VLDL Secretion by Apolipoprotein B Antisense Oligonucleotides Stimulates Autophagy of Endoplasmic Reticulum in the Liver, Preventing Steatosis

Thursday, February 21 | 9:50AM - 10:10AM
Coffee Break
Room: Hochelaga 1-3


Thursday, February 21 | 11:45AM - 4:30PM
On Own for Lunch and Recreation


Thursday, February 21 | 4:30PM - 5:00PM
Coffee Available
Room: Hochelaga 1-3


Thursday, February 21 | 5:00PM - 7:15PM
Autophagy in Inflammatory Disease and Cancer
Room: Le Grand Salon

Speaker 1 of 5
* Noboru Mizushima, University of Tokyo, Japan

Thursday, February 21 | 5:00PM - 7:15PM
Autophagy in Inflammatory Disease and Cancer
Room: Le Grand Salon

Speaker 2 of 5
Ramnik Xavier, Massachusetts General Hospital, USA
Autophagy Genes and Inflammatory Bowel Disease

Thursday, February 21 | 5:00PM - 7:15PM
Autophagy in Inflammatory Disease and Cancer
Room: Le Grand Salon

Speaker 3 of 5
Heinz Jungbluth, Newcomen Centre at St. Thomas', St. Thomas' Hospital, UK
Vici Syndrome, a Novel Multisystem Disorder Associated with Defective Autophagy

Thursday, February 21 | 5:00PM - 7:15PM
Autophagy in Inflammatory Disease and Cancer
Room: Le Grand Salon

Speaker 4 of 5
Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Autophagy in Tumor Cell Survival

Thursday, February 21 | 5:00PM - 7:15PM
Autophagy in Inflammatory Disease and Cancer
Room: Le Grand Salon

Speaker 5 of 5
Guido Kroemer, Cordeliers Research Center, France
Autophagy-Dependent Anti-Tumor Immunity

Thursday, February 21 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Hochelaga 1-3


Thursday, February 21 | 8:00PM - 11:00PM
Entertainment
Room: Hochelaga 1-3


Thursday, February 21 | 8:15PM - 11:00PM
Cash Bar
Room: Hochelaga 1-3


Friday, February 22 | 10:25AM - 10:25AM
Departure


*Session Chair.