Web Desc
Nutrition, Epigenetics and Human Disease
Organizer(s): Robert A. Waterland, David S. Rosenblatt and Patrick J. Stover
Date: February 19 - 24, 2013
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Sponsored by Cell Research, Nestlé Institute of Health Sciences and Takeda Pharmaceutical Company Limited
Summary of Meeting:
Transient nutritional exposures during critical developmental periods can induce permanent alterations in epigenetic regulation which program metabolic and other biological networks, with lifelong consequences. During other life stages nutrition can dynamically regulate epigenetic processes. There is increasing evidence that gene-nutrient interactions underlie susceptibility to various human diseases, through mechanisms that include interindividual variation in epigenomic profiles. The interaction of nutrition, epigenetics, and human disease is a rapidly evolving area of research with many fundamental outstanding questions and abundant opportunities to translate basic science discoveries to clinical and public health application. A meeting that brings together leaders in human nutrition, human genetics and epigenetics, clinical and animal studies of disease pathogenesis, inborn errors of metabolism, methyl metabolism, stem cell programming, genome stability, transcription, and developmental biology will accelerate and potentially transform research in this field.
Scholarship Deadline: October 17 2012
Discounted Abstract Deadline: October 17 2012
Abstract Deadline: November 19 2012
Discounted Registration Deadline: December 17 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Cell ResearchNestlé Institute of Health SciencesTakeda Pharmaceutical Company Limited
We gratefully acknowledge additional support for this conference from:
Abcam plcMarch of Dimes Foundation Grant No. 4-FY12-556Zymo Research Corporation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-04
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Promenade


Wednesday, February 20 | 8:00AM - 9:00AM
Breakfast
Room: Chamisa/Ortiz


Wednesday, February 20 | 9:00AM - 11:45AM
Nutrition and Epigenetics in Development and Disease of the
CNS

Room: Mesa A-B
Disruption of methyl metabolism resulting from vitamin B12 and folate deficiencies and aging are associated with neurodegenerative disorders ranging from peripheral neuropathies to subacute combined degeneration of the spinal cord. This session will focus on the interaction of nutrition and metabolism and epigenetic processes in diseases of the CNS, and its role in neurogenesis and aging.
Speaker 1 of 7
* David S. Rosenblatt, McGill University, Canada

Wednesday, February 20 | 9:00AM - 11:45AM
Nutrition and Epigenetics in Development and Disease of the
CNS

Room: Mesa A-B
Disruption of methyl metabolism resulting from vitamin B12 and folate deficiencies and aging are associated with neurodegenerative disorders ranging from peripheral neuropathies to subacute combined degeneration of the spinal cord. This session will focus on the interaction of nutrition and metabolism and epigenetic processes in diseases of the CNS, and its role in neurogenesis and aging.
Speaker 2 of 7
Robert A. Waterland, Baylor College of Medicine, USA
Welcome Remarks

Wednesday, February 20 | 9:00AM - 11:45AM
Nutrition and Epigenetics in Development and Disease of the
CNS

Room: Mesa A-B
Disruption of methyl metabolism resulting from vitamin B12 and folate deficiencies and aging are associated with neurodegenerative disorders ranging from peripheral neuropathies to subacute combined degeneration of the spinal cord. This session will focus on the interaction of nutrition and metabolism and epigenetic processes in diseases of the CNS, and its role in neurogenesis and aging.
Speaker 3 of 7
Arthur L. Beaudet, Baylor College of Medicine, USA
A Neuronal Carnitine Deficiency Hypothesis for Autism

Wednesday, February 20 | 9:00AM - 11:45AM
Nutrition and Epigenetics in Development and Disease of the
CNS

Room: Mesa A-B
Disruption of methyl metabolism resulting from vitamin B12 and folate deficiencies and aging are associated with neurodegenerative disorders ranging from peripheral neuropathies to subacute combined degeneration of the spinal cord. This session will focus on the interaction of nutrition and metabolism and epigenetic processes in diseases of the CNS, and its role in neurogenesis and aging.
Speaker 4 of 7
Peng Jin, Emory University School of Medicine, USA
Cytosine Modifications in Neurodevelopment and Diseases

Wednesday, February 20 | 9:00AM - 11:45AM
Nutrition and Epigenetics in Development and Disease of the
CNS

Room: Mesa A-B
Disruption of methyl metabolism resulting from vitamin B12 and folate deficiencies and aging are associated with neurodegenerative disorders ranging from peripheral neuropathies to subacute combined degeneration of the spinal cord. This session will focus on the interaction of nutrition and metabolism and epigenetic processes in diseases of the CNS, and its role in neurogenesis and aging.
Speaker 5 of 7
Steven H. Zeisel, University of North Carolina at Chapel Hill, USA
Diet Variation and Metabolic Inefficiencies in Choline and 1-Carbon Metabolism: Important Modifiers of Epigenetic Marks?

Wednesday, February 20 | 9:00AM - 11:45AM
Nutrition and Epigenetics in Development and Disease of the
CNS

Room: Mesa A-B
Disruption of methyl metabolism resulting from vitamin B12 and folate deficiencies and aging are associated with neurodegenerative disorders ranging from peripheral neuropathies to subacute combined degeneration of the spinal cord. This session will focus on the interaction of nutrition and metabolism and epigenetic processes in diseases of the CNS, and its role in neurogenesis and aging.
Speaker 6 of 7
Sivan Vadakkadath Meethal, University of Wisconsin-Madison, USA
Short Talk: Methylation/Demethylation Mechanisms Are Key to Folate-Induced Axon Regeneration in the Injured Central Nervous System

Wednesday, February 20 | 9:00AM - 11:45AM
Nutrition and Epigenetics in Development and Disease of the
CNS

Room: Mesa A-B
Disruption of methyl metabolism resulting from vitamin B12 and folate deficiencies and aging are associated with neurodegenerative disorders ranging from peripheral neuropathies to subacute combined degeneration of the spinal cord. This session will focus on the interaction of nutrition and metabolism and epigenetic processes in diseases of the CNS, and its role in neurogenesis and aging.
Speaker 7 of 7
Koji Hayakawa, University of Tokyo, Japan
Short Talk: Epigenetic Switching by Nutrition-Sensing Factor Ogt, Sirt1 and Mgea5 in Generation of Orexin Neurons from Mouse ES Cells and Human iPS Cells

Wednesday, February 20 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, February 20 | 10:15AM - 10:35AM
Coffee Break
Room: Promenade


Wednesday, February 20 | 11:45AM - 1:00PM
Poster Setup
Room: Mesa C


Wednesday, February 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Wednesday, February 20 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Wednesday, February 20 | 5:00PM - 7:00PM
Nutrient Regulation of the Epigenetic Machinery
Room: Mesa A-B
The establishment and maintenance of chromatin methylation is influenced by the total cellular methylation capacity. This capacity is determined by the expression level of DNA and histone methyltransferases, demethylases and the availability of the methyl donor S-adenosylmethionine.` There is increasing evidence that the expression of DNA and histone methyltransferases are responsive to dietary methionine, choline and other nutrients, and modest changes in methyltransferase expression levels have profound impact on chromatin methylation and gene expression. This session will investigate the mechanisms underlying the regulation of methyltransferase expression by nutrients, and its effect on chromatin methylation, gene expression and stem cell programming.
Speaker 1 of 5
* Patrick J. Stover, Cornell University, USA

Wednesday, February 20 | 5:00PM - 7:00PM
Nutrient Regulation of the Epigenetic Machinery
Room: Mesa A-B
The establishment and maintenance of chromatin methylation is influenced by the total cellular methylation capacity. This capacity is determined by the expression level of DNA and histone methyltransferases, demethylases and the availability of the methyl donor S-adenosylmethionine.` There is increasing evidence that the expression of DNA and histone methyltransferases are responsive to dietary methionine, choline and other nutrients, and modest changes in methyltransferase expression levels have profound impact on chromatin methylation and gene expression. This session will investigate the mechanisms underlying the regulation of methyltransferase expression by nutrients, and its effect on chromatin methylation, gene expression and stem cell programming.
Speaker 2 of 5
Roderick Dashwood, Oregon State University, USA
Mechanisms Underlying Bioactive Food Components and Histone Modifications

Wednesday, February 20 | 5:00PM - 7:00PM
Nutrient Regulation of the Epigenetic Machinery
Room: Mesa A-B
The establishment and maintenance of chromatin methylation is influenced by the total cellular methylation capacity. This capacity is determined by the expression level of DNA and histone methyltransferases, demethylases and the availability of the methyl donor S-adenosylmethionine.` There is increasing evidence that the expression of DNA and histone methyltransferases are responsive to dietary methionine, choline and other nutrients, and modest changes in methyltransferase expression levels have profound impact on chromatin methylation and gene expression. This session will investigate the mechanisms underlying the regulation of methyltransferase expression by nutrients, and its effect on chromatin methylation, gene expression and stem cell programming.
Speaker 3 of 5
Paolo Sassone-Corsi, University of California, Irvine, USA
Joining the Dots: Epigenetics, Metabolism and the Circadian Clock

Wednesday, February 20 | 5:00PM - 7:00PM
Nutrient Regulation of the Epigenetic Machinery
Room: Mesa A-B
The establishment and maintenance of chromatin methylation is influenced by the total cellular methylation capacity. This capacity is determined by the expression level of DNA and histone methyltransferases, demethylases and the availability of the methyl donor S-adenosylmethionine.` There is increasing evidence that the expression of DNA and histone methyltransferases are responsive to dietary methionine, choline and other nutrients, and modest changes in methyltransferase expression levels have profound impact on chromatin methylation and gene expression. This session will investigate the mechanisms underlying the regulation of methyltransferase expression by nutrients, and its effect on chromatin methylation, gene expression and stem cell programming.
Speaker 4 of 5
Andrea Fuso, Universita' di Roma, La Sapienza, Italy
Nutrient Regulation of One-Carbon Metabolism Modulates Gene-Specific Methylation: The Alzheimer’s Disease Model

Wednesday, February 20 | 5:00PM - 7:00PM
Nutrient Regulation of the Epigenetic Machinery
Room: Mesa A-B
The establishment and maintenance of chromatin methylation is influenced by the total cellular methylation capacity. This capacity is determined by the expression level of DNA and histone methyltransferases, demethylases and the availability of the methyl donor S-adenosylmethionine.` There is increasing evidence that the expression of DNA and histone methyltransferases are responsive to dietary methionine, choline and other nutrients, and modest changes in methyltransferase expression levels have profound impact on chromatin methylation and gene expression. This session will investigate the mechanisms underlying the regulation of methyltransferase expression by nutrients, and its effect on chromatin methylation, gene expression and stem cell programming.
Speaker 5 of 5
Joeva Jade Barrow, Harvard/Dana Farber Cancer Institute, USA
Short Talk: Artificial Zinc Finger DNA-Binding Domains Can Be Effective Tools to Identify Nutrient-Dependent Functional cis Elements in vivo

Wednesday, February 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Wednesday, February 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Mesa C


Thursday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Thursday, February 21 | 7:30AM - 8:00AM
Poster Setup
Room: Mesa C


Thursday, February 21 | 8:00AM - 5:00PM
Poster Viewing
Room: Mesa C


Thursday, February 21 | 8:00AM - 11:15AM
Nutrition and Epigenetics in Obesity
Room: Mesa A-B
Epigenetic mechanisms are likely to play an important role in body weight regulation. Animal models and emerging human data indicate that early environmental exposures (e.g. high-calorie diets, maternal obesity, etc.) can influence the development of body weight regulatory mechanisms, and thereby affect risk of obesity throughout life. The role of epigenetics in central and peripheral body weight regulatory mechanisms is attracting extensive attention. This session will cover the latest advances in clinical studies and animal models of 'nutritional programming' of obesity, and epigenetic mechanisms in central and peripheral body weight regulation.
Speaker 1 of 7
* Miguel Constância, University of Cambridge, UK

Thursday, February 21 | 8:00AM - 11:15AM
Nutrition and Epigenetics in Obesity
Room: Mesa A-B
Epigenetic mechanisms are likely to play an important role in body weight regulation. Animal models and emerging human data indicate that early environmental exposures (e.g. high-calorie diets, maternal obesity, etc.) can influence the development of body weight regulatory mechanisms, and thereby affect risk of obesity throughout life. The role of epigenetics in central and peripheral body weight regulatory mechanisms is attracting extensive attention. This session will cover the latest advances in clinical studies and animal models of 'nutritional programming' of obesity, and epigenetic mechanisms in central and peripheral body weight regulation.
Speaker 2 of 7
Richard B. Simerly, Vanderbilt University, USA
Nutritional-Endocrine Interactions in Postnatal Hypothalamic Development

Thursday, February 21 | 8:00AM - 11:15AM
Nutrition and Epigenetics in Obesity
Room: Mesa A-B
Epigenetic mechanisms are likely to play an important role in body weight regulation. Animal models and emerging human data indicate that early environmental exposures (e.g. high-calorie diets, maternal obesity, etc.) can influence the development of body weight regulatory mechanisms, and thereby affect risk of obesity throughout life. The role of epigenetics in central and peripheral body weight regulatory mechanisms is attracting extensive attention. This session will cover the latest advances in clinical studies and animal models of 'nutritional programming' of obesity, and epigenetic mechanisms in central and peripheral body weight regulation.
Speaker 3 of 7
Peter Kuehnen, Charité – Universitätsmedizin Berlin, Germany
A POMC Methylation Variant Associated with Childhood Obesity

Thursday, February 21 | 8:00AM - 11:15AM
Nutrition and Epigenetics in Obesity
Room: Mesa A-B
Epigenetic mechanisms are likely to play an important role in body weight regulation. Animal models and emerging human data indicate that early environmental exposures (e.g. high-calorie diets, maternal obesity, etc.) can influence the development of body weight regulatory mechanisms, and thereby affect risk of obesity throughout life. The role of epigenetics in central and peripheral body weight regulatory mechanisms is attracting extensive attention. This session will cover the latest advances in clinical studies and animal models of 'nutritional programming' of obesity, and epigenetic mechanisms in central and peripheral body weight regulation.
Speaker 4 of 7
Matthew V. Cannon, Cleveland Clinic Lerner Research Institute, USA
Short Talk: Genome-Wide Gene Expression and Epigenetic Analyses of Mice Born From Lean and Obese Mothers

Thursday, February 21 | 8:00AM - 11:15AM
Nutrition and Epigenetics in Obesity
Room: Mesa A-B
Epigenetic mechanisms are likely to play an important role in body weight regulation. Animal models and emerging human data indicate that early environmental exposures (e.g. high-calorie diets, maternal obesity, etc.) can influence the development of body weight regulatory mechanisms, and thereby affect risk of obesity throughout life. The role of epigenetics in central and peripheral body weight regulatory mechanisms is attracting extensive attention. This session will cover the latest advances in clinical studies and animal models of 'nutritional programming' of obesity, and epigenetic mechanisms in central and peripheral body weight regulation.
Speaker 5 of 7
Stephen T. Bradford, CSIRO/Garvan Institute of Medical Research, Australia
Short Talk: Analysis of the Methylome of Purified Visceral and Subcutaneous Adipocytes, Visceral Adipose Tissue and Blood from Three Lean Humans

Thursday, February 21 | 8:00AM - 11:15AM
Nutrition and Epigenetics in Obesity
Room: Mesa A-B
Epigenetic mechanisms are likely to play an important role in body weight regulation. Animal models and emerging human data indicate that early environmental exposures (e.g. high-calorie diets, maternal obesity, etc.) can influence the development of body weight regulatory mechanisms, and thereby affect risk of obesity throughout life. The role of epigenetics in central and peripheral body weight regulatory mechanisms is attracting extensive attention. This session will cover the latest advances in clinical studies and animal models of 'nutritional programming' of obesity, and epigenetic mechanisms in central and peripheral body weight regulation.
Speaker 6 of 7
Robert A. Waterland, Baylor College of Medicine, USA
Developmental Epigenetics and Obesity

Thursday, February 21 | 8:00AM - 11:15AM
Nutrition and Epigenetics in Obesity
Room: Mesa A-B
Epigenetic mechanisms are likely to play an important role in body weight regulation. Animal models and emerging human data indicate that early environmental exposures (e.g. high-calorie diets, maternal obesity, etc.) can influence the development of body weight regulatory mechanisms, and thereby affect risk of obesity throughout life. The role of epigenetics in central and peripheral body weight regulatory mechanisms is attracting extensive attention. This session will cover the latest advances in clinical studies and animal models of 'nutritional programming' of obesity, and epigenetic mechanisms in central and peripheral body weight regulation.
Speaker 7 of 7
Evan D. Rosen, Harvard University, USA
Epigenomic Analysis of Adipose Biology

Thursday, February 21 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Thursday, February 21 | 11:15AM - 12:00PM
Lunch
Room: Chamisa/Ortiz


Thursday, February 21 | 12:00PM - 2:30PM
Poster Session 2
Room: Mesa C


Thursday, February 21 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Thursday, February 21 | 5:00PM - 7:00PM
Nutrient, Methyl Metabolism and Epigenetic Interactions
Room: Mesa A-B
S-adenosylmethionine (SAM) is the universal methyl donor for chromatin methylation. S-adenosylhomocysteine (SAH) is the product of methylation reactions, and is a potent inhibitor of both DNA and histone methyltransferases. Therefore, the SAM/SAH ratio has been described as the cellular metabolic methylation potential. The SAM/SAH ratio is regulated over a broad dynamic range, and is sensitive and responsive to multiple nutrients. This session will cover recent advances in our understanding of nutrient regulation of the SAM/SAH ratio in the cell, and its impact on genome methylation, stem cell programming and transcription.
Speaker 1 of 5
* Jasper D. Rine, University of California, Berkeley, USA

Thursday, February 21 | 5:00PM - 7:00PM
Nutrient, Methyl Metabolism and Epigenetic Interactions
Room: Mesa A-B
S-adenosylmethionine (SAM) is the universal methyl donor for chromatin methylation. S-adenosylhomocysteine (SAH) is the product of methylation reactions, and is a potent inhibitor of both DNA and histone methyltransferases. Therefore, the SAM/SAH ratio has been described as the cellular metabolic methylation potential. The SAM/SAH ratio is regulated over a broad dynamic range, and is sensitive and responsive to multiple nutrients. This session will cover recent advances in our understanding of nutrient regulation of the SAM/SAH ratio in the cell, and its impact on genome methylation, stem cell programming and transcription.
Speaker 2 of 5
David S. Rosenblatt, McGill University, Canada
Discovering New Genes in the One Carbon Pathway Using Exome Sequencing-a RaDiCAL Approach

Thursday, February 21 | 5:00PM - 7:00PM
Nutrient, Methyl Metabolism and Epigenetic Interactions
Room: Mesa A-B
S-adenosylmethionine (SAM) is the universal methyl donor for chromatin methylation. S-adenosylhomocysteine (SAH) is the product of methylation reactions, and is a potent inhibitor of both DNA and histone methyltransferases. Therefore, the SAM/SAH ratio has been described as the cellular metabolic methylation potential. The SAM/SAH ratio is regulated over a broad dynamic range, and is sensitive and responsive to multiple nutrients. This session will cover recent advances in our understanding of nutrient regulation of the SAM/SAH ratio in the cell, and its impact on genome methylation, stem cell programming and transcription.
Speaker 3 of 5
Patrick J. Stover, Cornell University, USA
Nuclear One-Carbon Metabolism and Neural Tube Defects

Thursday, February 21 | 5:00PM - 7:00PM
Nutrient, Methyl Metabolism and Epigenetic Interactions
Room: Mesa A-B
S-adenosylmethionine (SAM) is the universal methyl donor for chromatin methylation. S-adenosylhomocysteine (SAH) is the product of methylation reactions, and is a potent inhibitor of both DNA and histone methyltransferases. Therefore, the SAM/SAH ratio has been described as the cellular metabolic methylation potential. The SAM/SAH ratio is regulated over a broad dynamic range, and is sensitive and responsive to multiple nutrients. This session will cover recent advances in our understanding of nutrient regulation of the SAM/SAH ratio in the cell, and its impact on genome methylation, stem cell programming and transcription.
Speaker 4 of 5
Rima Rozen, McGill University, Canada
Impact of Genetic and Nutritional Variation in Folate Metabolism on Cellular Methylation Capacity

Thursday, February 21 | 5:00PM - 7:00PM
Nutrient, Methyl Metabolism and Epigenetic Interactions
Room: Mesa A-B
S-adenosylmethionine (SAM) is the universal methyl donor for chromatin methylation. S-adenosylhomocysteine (SAH) is the product of methylation reactions, and is a potent inhibitor of both DNA and histone methyltransferases. Therefore, the SAM/SAH ratio has been described as the cellular metabolic methylation potential. The SAM/SAH ratio is regulated over a broad dynamic range, and is sensitive and responsive to multiple nutrients. This session will cover recent advances in our understanding of nutrient regulation of the SAM/SAH ratio in the cell, and its impact on genome methylation, stem cell programming and transcription.
Speaker 5 of 5
Erica D. Watson, University of Cambridge, UK
Short Talk: Transgenerational Epigenetic Effects of Folate Metabolism on Fetal and Placental Development

Thursday, February 21 | 7:00PM - 7:00PM
On Own for Dinner


Friday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Friday, February 22 | 8:00AM - 11:15AM
Nutrition and Developmental Epigenetics in the Endocrine Pan
creas

Room: Mesa A-B
The vast majority of type 2 diabetes is associated with obesity, a nutritionally-induced disease. Understanding epigenetic regulation in the endocrine pancreas could open the door to effective approaches to preventing or treating type 2 diabetes. This session will highlight recent mechanistic insights obtained by epigenomic profiling of human endocrine pancreas cell-types, epigenetic hallmarks of endocrine pancreas dysfunction, and epigenetic mechanisms of nutritional programming of impaired glucose homeostasis.
Speaker 1 of 7
* Robert A. Waterland, Baylor College of Medicine, USA

Friday, February 22 | 8:00AM - 11:15AM
Nutrition and Developmental Epigenetics in the Endocrine Pan
creas

Room: Mesa A-B
The vast majority of type 2 diabetes is associated with obesity, a nutritionally-induced disease. Understanding epigenetic regulation in the endocrine pancreas could open the door to effective approaches to preventing or treating type 2 diabetes. This session will highlight recent mechanistic insights obtained by epigenomic profiling of human endocrine pancreas cell-types, epigenetic hallmarks of endocrine pancreas dysfunction, and epigenetic mechanisms of nutritional programming of impaired glucose homeostasis.
Speaker 2 of 7
Miguel Constância, University of Cambridge, UK
Epigenetic Programming of Metabolic Health across the Life-Course

Friday, February 22 | 8:00AM - 11:15AM
Nutrition and Developmental Epigenetics in the Endocrine Pan
creas

Room: Mesa A-B
The vast majority of type 2 diabetes is associated with obesity, a nutritionally-induced disease. Understanding epigenetic regulation in the endocrine pancreas could open the door to effective approaches to preventing or treating type 2 diabetes. This session will highlight recent mechanistic insights obtained by epigenomic profiling of human endocrine pancreas cell-types, epigenetic hallmarks of endocrine pancreas dysfunction, and epigenetic mechanisms of nutritional programming of impaired glucose homeostasis.
Speaker 3 of 7
Frans C. Schuit, Katholieke Universiteit Leuven, Belgium
Beta-Cell Specific Repression of Disallowed Genes: Implications for Development and Disease

Friday, February 22 | 8:00AM - 11:15AM
Nutrition and Developmental Epigenetics in the Endocrine Pan
creas

Room: Mesa A-B
The vast majority of type 2 diabetes is associated with obesity, a nutritionally-induced disease. Understanding epigenetic regulation in the endocrine pancreas could open the door to effective approaches to preventing or treating type 2 diabetes. This session will highlight recent mechanistic insights obtained by epigenomic profiling of human endocrine pancreas cell-types, epigenetic hallmarks of endocrine pancreas dysfunction, and epigenetic mechanisms of nutritional programming of impaired glucose homeostasis.
Speaker 4 of 7
Ge Li, Baylor College of Medicine, USA
Short Talk: Early Postnatal Overnutrition Persistently Alters DNA Methylation in Pancreatic Islets

Friday, February 22 | 8:00AM - 11:15AM
Nutrition and Developmental Epigenetics in the Endocrine Pan
creas

Room: Mesa A-B
The vast majority of type 2 diabetes is associated with obesity, a nutritionally-induced disease. Understanding epigenetic regulation in the endocrine pancreas could open the door to effective approaches to preventing or treating type 2 diabetes. This session will highlight recent mechanistic insights obtained by epigenomic profiling of human endocrine pancreas cell-types, epigenetic hallmarks of endocrine pancreas dysfunction, and epigenetic mechanisms of nutritional programming of impaired glucose homeostasis.
Speaker 5 of 7
Stephanie-May Ruchat, Université de Sherbrooke, Canada
Short Talk: Genome-Wide DNA Methylation Profile Analyses in Placenta and Cord Blood Exposed or Not to Gestational Diabetes Mellitus

Friday, February 22 | 8:00AM - 11:15AM
Nutrition and Developmental Epigenetics in the Endocrine Pan
creas

Room: Mesa A-B
The vast majority of type 2 diabetes is associated with obesity, a nutritionally-induced disease. Understanding epigenetic regulation in the endocrine pancreas could open the door to effective approaches to preventing or treating type 2 diabetes. This session will highlight recent mechanistic insights obtained by epigenomic profiling of human endocrine pancreas cell-types, epigenetic hallmarks of endocrine pancreas dysfunction, and epigenetic mechanisms of nutritional programming of impaired glucose homeostasis.
Speaker 7 of 7
Jorge Ferrer, Imperial College London, UK
Charting the Genomic Dark Matter in Human Beta Cells

Friday, February 22 | 8:00AM - 11:15AM
Nutrition and Developmental Epigenetics in the Endocrine Pan
creas

Room: Mesa A-B
The vast majority of type 2 diabetes is associated with obesity, a nutritionally-induced disease. Understanding epigenetic regulation in the endocrine pancreas could open the door to effective approaches to preventing or treating type 2 diabetes. This session will highlight recent mechanistic insights obtained by epigenomic profiling of human endocrine pancreas cell-types, epigenetic hallmarks of endocrine pancreas dysfunction, and epigenetic mechanisms of nutritional programming of impaired glucose homeostasis.
Speaker 6 of 7
François Fuks, Université Libre de Bruxelles, Belgium
The Epigenome of Pancreatic Islets from T2D Patients

Friday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Friday, February 22 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Friday, February 22 | 11:15AM - 1:00PM
Poster Setup
Room: Mesa C


Friday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Friday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Friday, February 22 | 5:00PM - 7:00PM
Nutrients and Allelic Targeting of Epigenetic Signatures
Room: Mesa A-B
Various nutrient exposures can influence the expression of discrete genes and pathways by altering methylation patterns at specific genetic loci. Nutrients target specific loci for alterations in chromatin methylation and/or demethylation through nuclear receptors, signal transduction pathways and nuclear import processes. This session will focus on the fundamental mechanisms whereby nutrients regulate gene expression by targeted alterations in chromatin methylation, and its role in physiological adaptation maintaining cellular homeostasis.
Speaker 5 of 5
Elin Grundberg, McGill University and Genome Quebec Innovation Centre, Canada
Short Talk: Global DNA Methylation Patterns in Adipose Tissue from Twins and its Effect on Gene Expression and Disease

Friday, February 22 | 5:00PM - 7:00PM
Nutrients and Allelic Targeting of Epigenetic Signatures
Room: Mesa A-B
Various nutrient exposures can influence the expression of discrete genes and pathways by altering methylation patterns at specific genetic loci. Nutrients target specific loci for alterations in chromatin methylation and/or demethylation through nuclear receptors, signal transduction pathways and nuclear import processes. This session will focus on the fundamental mechanisms whereby nutrients regulate gene expression by targeted alterations in chromatin methylation, and its role in physiological adaptation maintaining cellular homeostasis.
Speaker 4 of 5
Tomi Pastinen, McGill University, Canada
Integrated Analysis of Genetic and Epigenetic Variation in Humans

Friday, February 22 | 5:00PM - 7:00PM
Nutrients and Allelic Targeting of Epigenetic Signatures
Room: Mesa A-B
Various nutrient exposures can influence the expression of discrete genes and pathways by altering methylation patterns at specific genetic loci. Nutrients target specific loci for alterations in chromatin methylation and/or demethylation through nuclear receptors, signal transduction pathways and nuclear import processes. This session will focus on the fundamental mechanisms whereby nutrients regulate gene expression by targeted alterations in chromatin methylation, and its role in physiological adaptation maintaining cellular homeostasis.
Speaker 3 of 5
Chen-Yu Zhang, Nanjing University, China
Extracellular microRNA: Function and Mechanism of Action

Friday, February 22 | 5:00PM - 7:00PM
Nutrients and Allelic Targeting of Epigenetic Signatures
Room: Mesa A-B
Various nutrient exposures can influence the expression of discrete genes and pathways by altering methylation patterns at specific genetic loci. Nutrients target specific loci for alterations in chromatin methylation and/or demethylation through nuclear receptors, signal transduction pathways and nuclear import processes. This session will focus on the fundamental mechanisms whereby nutrients regulate gene expression by targeted alterations in chromatin methylation, and its role in physiological adaptation maintaining cellular homeostasis.
Speaker 2 of 5
Kim Jongsook Kemper, University of Illinois at Urbana-Champaign, USA
The Role of PTMS of SHP in Transmitting Bile Acid Signaling to Epigenomic Regulation of Liver Metabolism

Friday, February 22 | 5:00PM - 7:00PM
Nutrients and Allelic Targeting of Epigenetic Signatures
Room: Mesa A-B
Various nutrient exposures can influence the expression of discrete genes and pathways by altering methylation patterns at specific genetic loci. Nutrients target specific loci for alterations in chromatin methylation and/or demethylation through nuclear receptors, signal transduction pathways and nuclear import processes. This session will focus on the fundamental mechanisms whereby nutrients regulate gene expression by targeted alterations in chromatin methylation, and its role in physiological adaptation maintaining cellular homeostasis.
Speaker 1 of 5
* Evan D. Rosen, Harvard University, USA

Friday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Friday, February 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Mesa C


Saturday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Saturday, February 23 | 8:00AM - 11:15AM
Nutritional Modulation of Stem Cell Programming
Room: Mesa A-B
Stem cells have the capacity to both self-renew and differentiate into specific cell types. In contrast to the pluripotent stem cells found only in the early embryo, lineage-restricted stem cells such as hematopoietic stem cells and neural stem cells persist into adulthood, and have the ability to differentiate into limited specific cell types. Embryonic and lineage-restricted stem cells offer excellent opportunities to understand fundamental mechanisms underlying nutritional influences on differentiation. Moreover, in cell types that are continuously replaced throughout life (like blood and intestinal epithelium) persistent effects of early nutrition must occur at the stem cell level. This session will focus on developmental epigenetics in embryonic and lineage-restricted stem cells, and nutritional influences on these processes.
Speaker 7 of 7
Chad A. Cowan, Beth Israel Deaconess Medical Center, USA
Genome Editing to Generate Human Cellular Models of Metabolic Disease

Saturday, February 23 | 8:00AM - 11:15AM
Nutritional Modulation of Stem Cell Programming
Room: Mesa A-B
Stem cells have the capacity to both self-renew and differentiate into specific cell types. In contrast to the pluripotent stem cells found only in the early embryo, lineage-restricted stem cells such as hematopoietic stem cells and neural stem cells persist into adulthood, and have the ability to differentiate into limited specific cell types. Embryonic and lineage-restricted stem cells offer excellent opportunities to understand fundamental mechanisms underlying nutritional influences on differentiation. Moreover, in cell types that are continuously replaced throughout life (like blood and intestinal epithelium) persistent effects of early nutrition must occur at the stem cell level. This session will focus on developmental epigenetics in embryonic and lineage-restricted stem cells, and nutritional influences on these processes.
Speaker 6 of 7
Lanlan Shen, Baylor College of Medicine, USA
Nutritional Influences on Stem Cell Developmental Epigenetics in the Colonic Crypt

Saturday, February 23 | 8:00AM - 11:15AM
Nutritional Modulation of Stem Cell Programming
Room: Mesa A-B
Stem cells have the capacity to both self-renew and differentiate into specific cell types. In contrast to the pluripotent stem cells found only in the early embryo, lineage-restricted stem cells such as hematopoietic stem cells and neural stem cells persist into adulthood, and have the ability to differentiate into limited specific cell types. Embryonic and lineage-restricted stem cells offer excellent opportunities to understand fundamental mechanisms underlying nutritional influences on differentiation. Moreover, in cell types that are continuously replaced throughout life (like blood and intestinal epithelium) persistent effects of early nutrition must occur at the stem cell level. This session will focus on developmental epigenetics in embryonic and lineage-restricted stem cells, and nutritional influences on these processes.
Speaker 5 of 7
Philippe Collas, University of Oslo, Norway
Short Talk: Repositioning of Lamin A/C-Associated Genes after Adipogenic Differentiation

Saturday, February 23 | 8:00AM - 11:15AM
Nutritional Modulation of Stem Cell Programming
Room: Mesa A-B
Stem cells have the capacity to both self-renew and differentiate into specific cell types. In contrast to the pluripotent stem cells found only in the early embryo, lineage-restricted stem cells such as hematopoietic stem cells and neural stem cells persist into adulthood, and have the ability to differentiate into limited specific cell types. Embryonic and lineage-restricted stem cells offer excellent opportunities to understand fundamental mechanisms underlying nutritional influences on differentiation. Moreover, in cell types that are continuously replaced throughout life (like blood and intestinal epithelium) persistent effects of early nutrition must occur at the stem cell level. This session will focus on developmental epigenetics in embryonic and lineage-restricted stem cells, and nutritional influences on these processes.
Speaker 4 of 7
Elizabeth Radford, University of Cambridge, UK
Short Talk: Paternal Intergenerational Transmission of an in utero Nutrition Induced Phenotype Is Associated with Altered DNA Methylation in Adult Germ Cells

Saturday, February 23 | 8:00AM - 11:15AM
Nutritional Modulation of Stem Cell Programming
Room: Mesa A-B
Stem cells have the capacity to both self-renew and differentiate into specific cell types. In contrast to the pluripotent stem cells found only in the early embryo, lineage-restricted stem cells such as hematopoietic stem cells and neural stem cells persist into adulthood, and have the ability to differentiate into limited specific cell types. Embryonic and lineage-restricted stem cells offer excellent opportunities to understand fundamental mechanisms underlying nutritional influences on differentiation. Moreover, in cell types that are continuously replaced throughout life (like blood and intestinal epithelium) persistent effects of early nutrition must occur at the stem cell level. This session will focus on developmental epigenetics in embryonic and lineage-restricted stem cells, and nutritional influences on these processes.
Speaker 3 of 7
Yi Eve Sun, University of California, Los Angeles, USA
Epigenetic Regulation of Stem Cell Differentiation

Saturday, February 23 | 8:00AM - 11:15AM
Nutritional Modulation of Stem Cell Programming
Room: Mesa A-B
Stem cells have the capacity to both self-renew and differentiate into specific cell types. In contrast to the pluripotent stem cells found only in the early embryo, lineage-restricted stem cells such as hematopoietic stem cells and neural stem cells persist into adulthood, and have the ability to differentiate into limited specific cell types. Embryonic and lineage-restricted stem cells offer excellent opportunities to understand fundamental mechanisms underlying nutritional influences on differentiation. Moreover, in cell types that are continuously replaced throughout life (like blood and intestinal epithelium) persistent effects of early nutrition must occur at the stem cell level. This session will focus on developmental epigenetics in embryonic and lineage-restricted stem cells, and nutritional influences on these processes.
Speaker 2 of 7
Guoliang Xu, Chinese Academy of Sciences, China
DNA Oxidation towards Totipotency in Mammalian Development

Saturday, February 23 | 8:00AM - 11:15AM
Nutritional Modulation of Stem Cell Programming
Room: Mesa A-B
Stem cells have the capacity to both self-renew and differentiate into specific cell types. In contrast to the pluripotent stem cells found only in the early embryo, lineage-restricted stem cells such as hematopoietic stem cells and neural stem cells persist into adulthood, and have the ability to differentiate into limited specific cell types. Embryonic and lineage-restricted stem cells offer excellent opportunities to understand fundamental mechanisms underlying nutritional influences on differentiation. Moreover, in cell types that are continuously replaced throughout life (like blood and intestinal epithelium) persistent effects of early nutrition must occur at the stem cell level. This session will focus on developmental epigenetics in embryonic and lineage-restricted stem cells, and nutritional influences on these processes.
Speaker 1 of 7
* Jean-Pierre Issa, Temple University School of Medicine, USA

Saturday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Saturday, February 23 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Saturday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Saturday, February 23 | 5:00PM - 7:00PM
Present and Future: Pressing Issues in Environmental Epigene
tics

Room: Mesa A-B

Speaker 1 of 5
* Dennis M. Bier, Baylor College of Medicine, USA

Saturday, February 23 | 5:00PM - 7:00PM
Present and Future: Pressing Issues in Environmental Epigene
tics

Room: Mesa A-B

Speaker 2 of 5
Jean-Pierre Issa, Temple University School of Medicine, USA
Epigenetic Drift

Saturday, February 23 | 5:00PM - 7:00PM
Present and Future: Pressing Issues in Environmental Epigene
tics

Room: Mesa A-B

Speaker 3 of 5
Andrew M. Prentice, London School of Hygiene and Tropical Medicine, UK
Long-Term Consequences of Maternal and Child (Mal)-Nutrition in Developing Countries

Saturday, February 23 | 5:00PM - 7:00PM
Present and Future: Pressing Issues in Environmental Epigene
tics

Room: Mesa A-B

Speaker 4 of 5
Sarah Finer, Queen Mary, University of London, UK
Short Talk: Epigenetic Variants Are Detectable in Young Adult Offspring Exposed to Famine in Early Development

Saturday, February 23 | 5:00PM - 7:00PM
Present and Future: Pressing Issues in Environmental Epigene
tics

Room: Mesa A-B

Speaker 5 of 5
Scott F. Gilbert, Swarthmore College, USA
The Global Environment and Ecological Developmental Biology: The Holobiont Perspective

Saturday, February 23 | 7:00PM - 7:15PM
Closing Remarks and Future Directions
Room: Mesa A-B

Speaker 1 of 2
David S. Rosenblatt, McGill University, Canada

Saturday, February 23 | 7:00PM - 7:15PM
Closing Remarks and Future Directions
Room: Mesa A-B

Speaker 2 of 2
Patrick J. Stover, Cornell University, USA

Saturday, February 23 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Promenade/Mesa Ballroom


Saturday, February 23 | 8:00PM - 11:00PM
Entertainment
Room: Mesa Ballroom


Saturday, February 23 | 9:00PM - 11:00PM
Cash Bar
Room: Mesa Ballroom


Sunday, February 24 | 10:25AM - 10:25AM
Departure


*Session Chair.