Web Desc
Myeloid Cells: Regulation and Inflammation
Organizer(s): Vincenzo Cerundolo, Gwendalyn J. Randolph and David M. Mosser
Date: February 19 - 24, 2013
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Novo Nordisk A/S
Summary of Meeting:
Recent results have shown that during inflammatory processes, myeloid cells exhibit extensive plasticity of their phenotype in response to numerous stimuli. This characteristic directly affects lymphocyte polarization and activity and is controlled by changes both at transcriptional and translational level. This previously unanticipated degree of epigenetic control of myeloid cells, which affects both innate and adaptive immune responses, is likely to impact several aspects of future studies in human immunology and to inform on immunotherapeutic strategies. This Keystone Symposia meeting will cover topical aspects of basic myeloid cell biology and their interface with clinical research, bringing together scientists and clinicians working on all the subtypes of myeloid cells in health and disease, from neutrophils and monocytes to macrophages and dendritic cells. The speakers will provide an overview of myeloid cell ontogeny, role of different myeloid cell subtypes in the modulation of innate and adaptive immunity, antigen capture and presentation, mobilization from the bone marrow and trafficking during inflammatory responses. The symposium will touch on multiple areas central to contemporary immunology and cell biology, including the interface between innate and adaptive immunity, as well as the mechanisms enforcing immunosuppression in cancer and infectious diseases.
Scholarship Deadline: October 18 2012
Discounted Abstract Deadline: October 18 2012
Abstract Deadline: November 19 2012
Discounted Registration Deadline: December 17 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Novo Nordisk A/S
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI104221-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Keystone Lodge Lobby


Wednesday, February 20 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Wednesday, February 20 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 1 of 2
* Vincenzo Cerundolo, University of Oxford, UK

Wednesday, February 20 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 2 of 2
Siamon Gordon, Chang Gung University / University of Oxford, UK
The Versatile Macrophage: Immune Receptors and Novel Functions

Wednesday, February 20 | 9:00AM - 12:15PM
Myeloid Lineage Differentiation
Room: Grays Peak

Speaker 1 of 7
* Christopher K. Glass, University of California, San Diego, USA

Wednesday, February 20 | 9:00AM - 12:15PM
Myeloid Lineage Differentiation
Room: Grays Peak

Speaker 2 of 7
Irving L. Weissman, Stanford University, USA
Normal and Neoplastic Stem Cells

Wednesday, February 20 | 9:00AM - 12:15PM
Myeloid Lineage Differentiation
Room: Grays Peak

Speaker 3 of 7
Paul S. Frenette, Albert Einstein College of Medicine, USA
Myeloid Cell-Induced Migration and Function in the Stem Cell Niche

Wednesday, February 20 | 9:00AM - 12:15PM
Myeloid Lineage Differentiation
Room: Grays Peak

Speaker 4 of 7
Paresh Vyas, University of Oxford, UK
Lineage Differentiation of AML

Wednesday, February 20 | 9:00AM - 12:15PM
Myeloid Lineage Differentiation
Room: Grays Peak

Speaker 5 of 7
Michael H. Sieweke, Technische Universitaet Dresden, Germany
Transcriptional Control of Macrophage Activity and Self-Renewal

Wednesday, February 20 | 9:00AM - 12:15PM
Myeloid Lineage Differentiation
Room: Grays Peak

Speaker 6 of 7
Florent Ginhoux, Singapore Immunology Network, Singapore
Short Talk: Revisiting the Ontogeny of the Mononuclear Phagocyte System: Embryonic and Adult Hematopoietic Contributions

Wednesday, February 20 | 9:00AM - 12:15PM
Myeloid Lineage Differentiation
Room: Grays Peak

Speaker 7 of 7
Craig Smuda, Feinberg School of Medicine, Northwestern University, USA
Short Talk: Ikaros Regulates Basophil and Mast Cell Development

Wednesday, February 20 | 9:40AM - 10:00AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 20 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, February 20 | 12:15PM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Wednesday, February 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Wednesday, February 20 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 20 | 5:00PM - 7:00PM
Plasticity of Myeloid Cells
Room: Grays Peak

Speaker 1 of 5
* Gwendalyn J. Randolph, Washington University, USA

Wednesday, February 20 | 5:00PM - 7:00PM
Plasticity of Myeloid Cells
Room: Grays Peak

Speaker 2 of 5
David M. Mosser, University of Maryland, USA
Macrophage Plasticity and Intrinsic Control of the Activation Response

Wednesday, February 20 | 5:00PM - 7:00PM
Plasticity of Myeloid Cells
Room: Grays Peak

Speaker 3 of 5
Vincenzo Cerundolo, University of Oxford, UK
Ability of Invariant NKT Cells to Modulate the Phenotype and Function of Myeloid Cells

Wednesday, February 20 | 5:00PM - 7:00PM
Plasticity of Myeloid Cells
Room: Grays Peak

Speaker 4 of 5
Judith E. Allen, University of Manchester, UK
Local Macrophage Proliferation in Type 2 Immunity

Wednesday, February 20 | 5:00PM - 7:00PM
Plasticity of Myeloid Cells
Room: Grays Peak

Speaker 5 of 5
Dmitry Ostanin, Bristol Myers Squibb, USA
Short Talk: Reprogramming of Myeloid Cells to Treat Inflammatory Bowel Diseases

Wednesday, February 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Wednesday, February 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Thursday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Thursday, February 21 | 8:00AM - 11:00AM
Myeloid Cells during Inflammation
Room: Grays Peak

Speaker 1 of 7
* David M. Mosser, University of Maryland, USA

Thursday, February 21 | 8:00AM - 11:00AM
Myeloid Cells during Inflammation
Room: Grays Peak

Speaker 2 of 7
Eric G. Pamer, University of Chicago, USA
Ly6Chi Monocytes and Immune Defense Against Mycobacterium Tuberculosis Infection

Thursday, February 21 | 8:00AM - 11:00AM
Myeloid Cells during Inflammation
Room: Grays Peak

Speaker 3 of 7
Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Macrophages and Tumor Progression

Thursday, February 21 | 8:00AM - 11:00AM
Myeloid Cells during Inflammation
Room: Grays Peak

Speaker 4 of 7
Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany
NETs – From Infection to Autoimmunity

Thursday, February 21 | 8:00AM - 11:00AM
Myeloid Cells during Inflammation
Room: Grays Peak

Speaker 5 of 7
John Robert Grainger, University of Manchester, UK
Short Talk: Inflammatory Monocytes Regulate Pathologic Responses to Commensals during Acute Gastrointestinal Infection

Thursday, February 21 | 8:00AM - 11:00AM
Myeloid Cells during Inflammation
Room: Grays Peak

Speaker 6 of 7
Jing Wang, Augusta University, USA
Short Talk: Neutrophil Infiltration during Inflammation is Regulated by PILRalpha via Modulation of Integrin Activation

Thursday, February 21 | 8:00AM - 11:00AM
Myeloid Cells during Inflammation
Room: Grays Peak

Speaker 7 of 7
Romain Olekhnovitch, Pasteur Institute, France
Short Talk: The Control of an Intracellular Parasite by iNOS Is Regulated at the Tissue Level Rather than in a Cell-Intrinsic Manner

Thursday, February 21 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 21 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, February 21 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Thursday, February 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Thursday, February 21 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Chemokine Receptors
Room: Grays Peak

Speaker 1 of 7
* Eric G. Pamer, University of Chicago, USA

Thursday, February 21 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Chemokine Receptors
Room: Grays Peak

Speaker 2 of 7
Ludovic Arnold, Pierre and Marie Curie University-UPMC, France
CCR2/CCL2 and CX3CL1/CX3CR1 Chemokine Pathways Play Opposing Roles during Muscle Regeneration

Thursday, February 21 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Chemokine Receptors
Room: Grays Peak

Speaker 3 of 7
Junjie Mei, Children's Hospital of Philadelphia, USA
Platelet CXCL7 and CXCL4 Inhibit Chemokine Scavenging and Increase Neutrophil transmigration

Thursday, February 21 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Chemokine Receptors
Room: Grays Peak

Speaker 4 of 7
Melody Wei-Ning Chang, University of Melbourne, Australia
Interferon Regulatory Factor 4 and Inflammation

Thursday, February 21 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Chemokine Receptors
Room: Grays Peak

Speaker 5 of 7
Boaz van Driel, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Role Slamf1 in Colitis

Thursday, February 21 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Chemokine Receptors
Room: Grays Peak

Speaker 6 of 7
Eva Van Overmeire, VIB-Vrije Universiteit Brussel, Belgium
Assessment of the CCL17/CCR4 Axis, Regulated by the MHC II(high) Tumor-Associated Macrophage Subset, in Shaping the Inflammatory Tumor Infiltrate

Thursday, February 21 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Chemokine Receptors
Room: Grays Peak

Speaker 7 of 7
Kavitha Subramanian, University of Cincinnati, USA
Sequestration of Zinc in Macrophages Is Essential to Restrict Survival of an Intracellular Pathogen

Thursday, February 21 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 21 | 5:00PM - 7:00PM
Myeloid Cell Migration and Trafficking
Room: Grays Peak

Speaker 1 of 5
* Matteo Iannacone, Fondazione Centro San Raffaele, Italy

Thursday, February 21 | 5:00PM - 7:00PM
Myeloid Cell Migration and Trafficking
Room: Grays Peak

Speaker 2 of 5
Miriam Merad, Mount Sinai School of Medicine, USA
Myeloid Cell Control of Hematopoietic Cell Transplant Outcome

Thursday, February 21 | 5:00PM - 7:00PM
Myeloid Cell Migration and Trafficking
Room: Grays Peak

Speaker 3 of 5
Paul Kubes, University of Calgary, Canada
Neutrophil Trafficking in vivo in Different Vascular Beds and to Different Stimuli

Thursday, February 21 | 5:00PM - 7:00PM
Myeloid Cell Migration and Trafficking
Room: Grays Peak

Speaker 4 of 5
Leo M. Carlin, Imperial College London, UK
Inflammatory Monocytes

Thursday, February 21 | 5:00PM - 7:00PM
Myeloid Cell Migration and Trafficking
Room: Grays Peak

Speaker 5 of 5
Ricardo A. Luz, Federal University of Rio de Janeiro, Brazil
Short Talk: 5-Lipoxygenase-Dependent Recruitment of Neutrophils by Eotaxin-Stimulated Murine Eosinophils

Thursday, February 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Thursday, February 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Friday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Friday, February 22 | 8:00AM - 11:15AM
Signaling Events
Room: Grays Peak

Speaker 1 of 7
* Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA

Friday, February 22 | 8:00AM - 11:15AM
Signaling Events
Room: Grays Peak

Speaker 2 of 7
Mikael J. Pittet, Massachusetts General Hospital, USA, USA
Control of Macrophage Production by Cancer

Friday, February 22 | 8:00AM - 11:15AM
Signaling Events
Room: Grays Peak

Speaker 3 of 7
Caetano Reis e Sousa, Francis Crick Institute, UK
Innate Immune Recognition of Cell Death

Friday, February 22 | 8:00AM - 11:15AM
Signaling Events
Room: Grays Peak

Speaker 4 of 7
Alan Aderem, Center for Infectious Disease Research, USA
A Systems Approach to Dissecting Immunity

Friday, February 22 | 8:00AM - 11:15AM
Signaling Events
Room: Grays Peak

Speaker 5 of 7
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
The NLR Proteins and Myeloid-Macrophage Functions

Friday, February 22 | 8:00AM - 11:15AM
Signaling Events
Room: Grays Peak

Speaker 6 of 7
John J. Seeley, Columbia University, USA
Short Talk: miR-222 Suppresses Inflammation during Macrophage LPS Tolerance by Targeting Tnfa and the Chromatin Remodeler Brg1

Friday, February 22 | 8:00AM - 11:15AM
Signaling Events
Room: Grays Peak

Speaker 7 of 7
Steven C. Ley, Francis Crick Institute, UK
Short Talk: Regulation of Tpl-2 Signaling by IkappaB Kinase

Friday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Friday, February 22 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Friday, February 22 | 11:15AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Friday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Friday, February 22 | 2:30PM - 4:30PM
Workshop 2: Myeloid Regulatory Cells
Room: Grays Peak

Speaker 1 of 7
* Siamon Gordon, Chang Gung University / University of Oxford, UK

Friday, February 22 | 2:30PM - 4:30PM
Workshop 2: Myeloid Regulatory Cells
Room: Grays Peak

Speaker 2 of 7
Sidney M. Morris, Jr., University of Pittsburgh, USA
Tuning the Murine Macrophage M2 Phenotype: IL-4 and cAMP Synergistically Activate the Arginase I Promoter

Friday, February 22 | 2:30PM - 4:30PM
Workshop 2: Myeloid Regulatory Cells
Room: Grays Peak

Speaker 3 of 7
Andreas Alber, Roslin Institute, University of Edinburgh, UK
PHD Inhibition Induces M2 Macrophage Polarization and Has Differential Effects on Lung Fibrosis

Friday, February 22 | 2:30PM - 4:30PM
Workshop 2: Myeloid Regulatory Cells
Room: Grays Peak

Speaker 4 of 7
Erik Thiele Orberg, University Clinic Rechts der Isar, Technical University Munich, Germany
Hif-1alpha and the Regulation of Pro-Tumoral Function of MDSC in Colitis-Induced Colon Cancer

Friday, February 22 | 2:30PM - 4:30PM
Workshop 2: Myeloid Regulatory Cells
Room: Grays Peak

Speaker 5 of 7
Richard N. Hanna, MedImmune, USA
NR4A1 (Nur77) Dependent Monocytes Patrol the Lung Vasculature and Inhibit Tumor Cell Invasion

Friday, February 22 | 2:30PM - 4:30PM
Workshop 2: Myeloid Regulatory Cells
Room: Grays Peak

Speaker 6 of 7
Elio Schouppe, Vrije Universiteit Brussel, VIB, Belgium
Distinct Tumor-Induced Myeloid-Derived Suppressor Cell Subsets Differentially Affect Multiple Aspects of CD8+ T-Cell Activation

Friday, February 22 | 2:30PM - 4:30PM
Workshop 2: Myeloid Regulatory Cells
Room: Grays Peak

Speaker 7 of 7
Ruth A. Franklin, Harvard University, USA
Tumor Growth Induces the Differentiation of a Novel Subset of Tumor-Associated Macrophages from CCR2+ Monocytes

Friday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Friday, February 22 | 5:00PM - 7:15PM
Myeloid Cells during Pathogen Infections
Room: Grays Peak

Speaker 1 of 5
* Judith E. Allen, University of Manchester, UK

Friday, February 22 | 5:00PM - 7:15PM
Myeloid Cells during Pathogen Infections
Room: Grays Peak

Speaker 2 of 5
Alan Sher, NIAID, National Institutes of Health, USA
Regulation of Myeloid Cell Differentiation and Function in the Innate Response to Toxoplasma gondii

Friday, February 22 | 5:00PM - 7:15PM
Myeloid Cells during Pathogen Infections
Room: Grays Peak

Speaker 3 of 5
Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA

Friday, February 22 | 5:00PM - 7:15PM
Myeloid Cells during Pathogen Infections
Room: Grays Peak

Speaker 4 of 5
John W. Schoggins, University of Texas Southwestern Medical Center, USA
Dengue Virus-Host Interactions and the Antiviral Interferon Response

Friday, February 22 | 5:00PM - 7:15PM
Myeloid Cells during Pathogen Infections
Room: Grays Peak

Speaker 5 of 5
Denise M. Monack, Stanford University, USA
The Battle within Macrophages: Mechanisms of Intracellular Salmonella Recognition and Evasion

Friday, February 22 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Friday, February 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Shavano/Torreys


Saturday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Saturday, February 23 | 8:00AM - 11:00AM
Myeloid Cells Modulating Adaptive Immune Responses
Room: Grays Peak

Speaker 1 of 7
* Vincenzo Cerundolo, University of Oxford, UK

Saturday, February 23 | 8:00AM - 11:00AM
Myeloid Cells Modulating Adaptive Immune Responses
Room: Grays Peak

Speaker 2 of 7
Gwendalyn J. Randolph, Washington University, USA
Monocyte Emigration and Differentiation in the Steady State versus Acute Inflammatory Responses

Saturday, February 23 | 8:00AM - 11:00AM
Myeloid Cells Modulating Adaptive Immune Responses
Room: Grays Peak

Speaker 3 of 7
Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging Myeloid Cell Dynamics, Tissue Positioning, and Function

Saturday, February 23 | 8:00AM - 11:00AM
Myeloid Cells Modulating Adaptive Immune Responses
Room: Grays Peak

Speaker 4 of 7
Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
DC and Adaptive Immune Response

Saturday, February 23 | 8:00AM - 11:00AM
Myeloid Cells Modulating Adaptive Immune Responses
Room: Grays Peak

Speaker 5 of 7
Matteo Iannacone, Fondazione Centro San Raffaele, Italy
Lymph Node Macrophages and Antiviral Immune Responses

Saturday, February 23 | 8:00AM - 11:00AM
Myeloid Cells Modulating Adaptive Immune Responses
Room: Grays Peak

Speaker 6 of 7
Astrid E. Cardona, University of Texas at San Antonio, USA
Short Talk: Regulation of Adaptive Immunity by the Fractalkine Receptor during Autoimmune Inflammation

Saturday, February 23 | 8:00AM - 11:00AM
Myeloid Cells Modulating Adaptive Immune Responses
Room: Grays Peak

Speaker 7 of 7
Olga Barreiro, National Center of Cardiovascular Research, Spain
Short Talk: A Novel Subset of Skin Extramedullary Blood-Auditor Macrophages Able to Generate CD8 Memory T Cells Specific for Circulating Antigens

Saturday, February 23 | 9:00AM - 9:20AM
Coffee Break
Room: Longs Peak Foyer


Saturday, February 23 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Saturday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Saturday, February 23 | 5:00PM - 7:00PM
Myeloid Cells in Pathologies and in the Clinic
Room: Grays Peak

Speaker 1 of 5
* Ronald N. Germain, NIAID, National Institutes of Health, USA

Saturday, February 23 | 5:00PM - 7:00PM
Myeloid Cells in Pathologies and in the Clinic
Room: Grays Peak

Speaker 2 of 5
Virginia Pascual, Cornell University, USA
Neutrophils and SLE

Saturday, February 23 | 5:00PM - 7:00PM
Myeloid Cells in Pathologies and in the Clinic
Room: Grays Peak

Speaker 3 of 5
Christopher K. Glass, University of California, San Diego, USA
A Genome-Wide View of Macrophage Activation

Saturday, February 23 | 5:00PM - 7:00PM
Myeloid Cells in Pathologies and in the Clinic
Room: Grays Peak

Speaker 4 of 5
Ajay Chawla, Merck Research Labs, USA
Monocyte Subsets and Metabolic Disease

Saturday, February 23 | 5:00PM - 7:00PM
Myeloid Cells in Pathologies and in the Clinic
Room: Grays Peak

Speaker 5 of 5
Lai Guan Ng, Singapore Immunology Network, Singapore
Short Talk: G-CSF and AMD 3100 Induce Mobilization of Neutrophils to the Blood from Different Neutrophil Pools through Distinct Cellular Mechanisms

Saturday, February 23 | 7:00PM - 7:15PM
Concluding Remarks
Room: Grays Peak

Speaker 1 of 1
Gwendalyn J. Randolph, Washington University, USA

Saturday, February 23 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Saturday, February 23 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys


Saturday, February 23 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Sunday, February 24 | 10:25AM - 10:25AM
Departure


*Session Chair.