Web Desc
Stem Cell Regulation in Homeostasis and Disease
Organizer(s): Sean J. Morrison, Iannis Aifantis and Yukiko M. Yamashita
Date: February 24 - March 01, 2013
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by Cell Research, EMD Millipore and Life Technologies Corporation
Summary of Meeting:
Stem cell regulation is critical for tissue development and maintenance. Defects in stem cell regulatory mechanisms are thought to contribute to many diseases, including congenital diseases, cancer and diseases of aging; therefore, these mechanisms are of interest to a diverse audience. Recent stem cell meetings have tended to focus on the interface of stem cells and cancer, or on reprogramming. This has left the majority of stem cell biologists with fewer forums that focus on the basic mechanisms that regulate stem cell function. And yet critical advances are occurring that give glimpses of new molecular mechanisms that regulate stem cell and tissue homeostasis. The goal of this Keystone Symposia meeting is to identify new and common mechanisms governing stem cell function and differentiation across tissues and across species. To address this, the meeting is organized into sessions according to distinct modes of stem cell regulation, without regard to species, in a way that might highlight novel paradigms of regulation. Speakers were chosen, first and foremost, based on research quality, and then to cover broad areas of stem cell research. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact. The focus on stem cell regulation in general provides an umbrella under which speakers from different areas of research (e.g., developmental biology, tissue growth and homeostasis, regeneration, cancer and aging) are being brought together in an environment that is highly conducive to cross-talk.
Scholarship Deadline: October 24 2012
Discounted Abstract Deadline: October 24 2012
Abstract Deadline: November 27 2012
Discounted Registration Deadline: December 18 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Cell ResearchEMD MilliporeLife Technologies Corporation
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.The Company of Biologists LtdMarch of Dimes Foundation Grant No. 4-FY12-556Thermo Fisher Scientific, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1R13HD075474-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 24 | 4:00PM - 8:00PM
Arrival and Registration
Room: Van Horne Foyer


Monday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne A/B


Monday, February 25 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Van Horne C

Speaker 1 of 2
* Sean J. Morrison, University of Texas Southwestern Medical Center, USA

Monday, February 25 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Van Horne C

Speaker 2 of 2
George Q. Daley, HHMI/Boston Children's Hospital, USA
Disease Modeling with iPS Cells

Monday, February 25 | 9:00AM - 11:45AM
Pluripotency and Disease Modeling
Room: Van Horne C

Speaker 1 of 6
Alysson R. Muotri, University of California, San Diego, USA
Modeling Autism Spectrum Disorders Using Human Neurons

Monday, February 25 | 9:00AM - 11:45AM
Pluripotency and Disease Modeling
Room: Van Horne C

Speaker 2 of 6
Evangelos Kiskinis, Northwestern University Feinberg School of Medicine, USA
Short Talk: Motor Neurons Generated from ALS Patient-Specific iPS Cells Recapitulate Key Aspects of the Disease

Monday, February 25 | 9:00AM - 11:45AM
Pluripotency and Disease Modeling
Room: Van Horne C

Speaker 3 of 6
Deepak Srivastava, Gladstone Institutes, USA
Direct Reprogamming of Fibroblasts to Cardiomyocyte-Like Cells

Monday, February 25 | 9:00AM - 11:45AM
Pluripotency and Disease Modeling
Room: Van Horne C

Speaker 4 of 6
Danwei Huangfu, Memorial Sloan Kettering Cancer Institute, USA
Short Talk: Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State

Monday, February 25 | 9:00AM - 11:45AM
Pluripotency and Disease Modeling
Room: Van Horne C

Speaker 5 of 6
Kathrin Plath, University of California, Los Angeles, USA
Understanding Mechanisms of Reprogramming

Monday, February 25 | 9:00AM - 11:45AM
Pluripotency and Disease Modeling
Room: Van Horne C

Speaker 6 of 6
Thea D. Tlsty, University of California, San Francisco, USA
Extensive Plasticity in Rare Somatic Cells Found in Adult Human Tissue

Monday, February 25 | 9:40AM - 10:00AM
Coffee Break
Room: Van Horne Foyer


Monday, February 25 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Monday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Monday, February 25 | 5:00PM - 7:00PM
Stem Cells and Regeneration
Room: Van Horne C

Speaker 1 of 5
* Allan C. Spradling, HHMI/Carnegie Institute, USA

Monday, February 25 | 5:00PM - 7:00PM
Stem Cells and Regeneration
Room: Van Horne C

Speaker 2 of 5
Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA
The Developmental Biology of a Totipotent, Adult Stem Cell Population

Monday, February 25 | 5:00PM - 7:00PM
Stem Cells and Regeneration
Room: Van Horne C

Speaker 3 of 5
Trista E. North, Beth Israel Deaconess Medical Center, USA
Metabolic Regulation of Hematopoietic Stem Cell Formation and Function

Monday, February 25 | 5:00PM - 7:00PM
Stem Cells and Regeneration
Room: Van Horne C

Speaker 4 of 5
Bruce M. Wang, Stanford University, USA
Short Talk: Wnt Signaling and the Stem Cell Niche in Progenitor Cell Mediated Liver Regeneration

Monday, February 25 | 5:00PM - 7:00PM
Stem Cells and Regeneration
Room: Van Horne C

Speaker 5 of 5
David T. Scadden, Massachusetts General Hospital and Harvard University, USA
The Pysiological Function of Mesenchymal Stem Cells

Monday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne A/B


Tuesday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne A/B


Tuesday, February 26 | 8:00AM - 11:15AM
Niche Regulation of Stem Cell Function. Session sponsored b
y Development.

Room: Van Horne C
Support for these organized-selected speakers generously provided by this journal.
Speaker 1 of 7
* David T. Scadden, Massachusetts General Hospital and Harvard University, USA

Tuesday, February 26 | 8:00AM - 11:15AM
Niche Regulation of Stem Cell Function. Session sponsored b
y Development.

Room: Van Horne C
Support for these organized-selected speakers generously provided by this journal.
Speaker 2 of 7
Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Hematopoietic Stem Cells and Lymphoid Progenitors Occupy Distinct Niches in the Bone Marrow

Tuesday, February 26 | 8:00AM - 11:15AM
Niche Regulation of Stem Cell Function. Session sponsored b
y Development.

Room: Van Horne C
Support for these organized-selected speakers generously provided by this journal.
Speaker 3 of 7
Miriam Grunewald, Hebrew University, Israel
Short Talk: The Vascular Endothelial Growth Factor Generates a Fully Functional Hematopoietic Stem Cells Niche in the Spleen

Tuesday, February 26 | 8:00AM - 11:15AM
Niche Regulation of Stem Cell Function. Session sponsored b
y Development.

Room: Van Horne C
Support for these organized-selected speakers generously provided by this journal.
Speaker 4 of 7
Fiona Doetsch, University of Basel, Switzerland
Stem Cells and their Niche in the Adult Mammalian Brain

Tuesday, February 26 | 8:00AM - 11:15AM
Niche Regulation of Stem Cell Function. Session sponsored b
y Development.

Room: Van Horne C
Support for these organized-selected speakers generously provided by this journal.
Speaker 5 of 7
Brett Shook, Yale University, USA
Extrinsic Regulation of Skin Stem Cells

Tuesday, February 26 | 8:00AM - 11:15AM
Niche Regulation of Stem Cell Function. Session sponsored b
y Development.

Room: Van Horne C
Support for these organized-selected speakers generously provided by this journal.
Speaker 6 of 7
Peter Andersen, Johns Hopkins University School of Medicine, USA
Short Talk: Lineage-Specific Mosaicism Identifies Renewing Cardiac Progenitor Cells and their Niche

Tuesday, February 26 | 8:00AM - 11:15AM
Niche Regulation of Stem Cell Function. Session sponsored b
y Development.

Room: Van Horne C
Support for these organized-selected speakers generously provided by this journal.
Speaker 7 of 7
Allan C. Spradling, HHMI/Carnegie Institute, USA
Stem Cells and Tissue Homeostasis

Tuesday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Tuesday, February 26 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Tuesday, February 26 | 11:15AM - 1:00PM
Poster Setup
Room: Van Horne A/B


Tuesday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Van Horne A/B


Tuesday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, February 26 | 5:00PM - 7:00PM
Emerging Regulatory Mechanisms
Room: Van Horne C

Speaker 1 of 5
* Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA

Tuesday, February 26 | 5:00PM - 7:00PM
Emerging Regulatory Mechanisms
Room: Van Horne C

Speaker 2 of 5
Iannis Aifantis, New York University School of Medicine, USA
Regulation of Stem Cell Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System

Tuesday, February 26 | 5:00PM - 7:00PM
Emerging Regulatory Mechanisms
Room: Van Horne C

Speaker 3 of 5
Ketan J. Patel, MRC Laboratory of Molecular Biology, UK
Mechanisms to Prevent DNA Damage by Metabolites in Stem Cells

Tuesday, February 26 | 5:00PM - 7:00PM
Emerging Regulatory Mechanisms
Room: Van Horne C

Speaker 4 of 5
Yukiko M. Yamashita, University of Michigan, Ann Arbor, USA
Asymmetric Chromosome Segregation during Stem Cell Division in Drosophila Male Germline

Tuesday, February 26 | 5:00PM - 7:00PM
Emerging Regulatory Mechanisms
Room: Van Horne C

Speaker 5 of 5
Jean-Pierre Etchegaray, Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: The Histone Deacetylase SIRT6 Plays a Critical Role in Mouse Embryonic Stem Cell Differentiation

Tuesday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne A/B


Tuesday, February 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Van Horne A/B


Wednesday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne A/B


Wednesday, February 27 | 8:00AM - 11:15AM
RNA Regulation and Stem Cells
Room: Van Horne C

Speaker 1 of 7
* Yukiko M. Yamashita, University of Michigan, Ann Arbor, USA

Wednesday, February 27 | 8:00AM - 11:15AM
RNA Regulation and Stem Cells
Room: Van Horne C

Speaker 2 of 7
Haifan Lin, Yale University, USA
The Yb Body, a Novel Organelle Involved in Niche Signaling of Germline Stem Cell Self-Renewal

Wednesday, February 27 | 8:00AM - 11:15AM
RNA Regulation and Stem Cells
Room: Van Horne C

Speaker 3 of 7
Robert H. Blelloch, University of California, San Francisco, USA
MicroRNA Regulation of Pluripotency

Wednesday, February 27 | 8:00AM - 11:15AM
RNA Regulation and Stem Cells
Room: Van Horne C

Speaker 4 of 7
Richard I. Gregory, Harvard Medical School, USA
Lin28, Let-7 and Stem Cells

Wednesday, February 27 | 8:00AM - 11:15AM
RNA Regulation and Stem Cells
Room: Van Horne C

Speaker 5 of 7
Robert A.J. Signer, University of California, San Diego, USA
Short Talk: The Rate of Protein Translation Regulates Hematopoietic Stem Cell Self-Renewal

Wednesday, February 27 | 8:00AM - 11:15AM
RNA Regulation and Stem Cells
Room: Van Horne C

Speaker 6 of 7
Noelia Urban, Institute of Molecular Biotechnology Austria, Austria
Short Talk: Degradation of Ascl1 by Huwe1 Is Essential for Stem Cells Maintenance and Neurogenesis in the Adult Hippocampus

Wednesday, February 27 | 8:00AM - 11:15AM
RNA Regulation and Stem Cells
Room: Van Horne C

Speaker 7 of 7
Judith E. Kimble, University of Wisconsin, Madison, USA
Notch Signaling and an RNA Regulatory Network Control C. elegans Germline Stem Cells

Wednesday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Wednesday, February 27 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, February 27 | 11:15AM - 1:00PM
Poster Setup
Room: Van Horne A/B


Wednesday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Van Horne A/B


Wednesday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, February 27 | 5:00PM - 7:00PM
Stem Cells and Cancer
Room: Van Horne C

Speaker 1 of 5
* Iannis Aifantis, New York University School of Medicine, USA

Wednesday, February 27 | 5:00PM - 7:00PM
Stem Cells and Cancer
Room: Van Horne C

Speaker 2 of 5
Richard J. Gilbertson, University of Cambridge, UK
Organism-Wide Mapping of Stem Cells and Cancer Origins

Wednesday, February 27 | 5:00PM - 7:00PM
Stem Cells and Cancer
Room: Van Horne C

Speaker 3 of 5
Austin Gurney, Napa Biotechnology Consulting, USA
Targeting Stem Cell Pathways in Cancer

Wednesday, February 27 | 5:00PM - 7:00PM
Stem Cells and Cancer
Room: Van Horne C

Speaker 4 of 5
Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
A Defined Subpopulation of Glioblastoma Cells Is Responsible for Tumor Recurrence following Chemotherapy

Wednesday, February 27 | 5:00PM - 7:00PM
Stem Cells and Cancer
Room: Van Horne C

Speaker 5 of 5
Hans-Guido Wendel, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Differential MYC Requirement in Healthy and Malignant Tissues Derived from Induced-Pluripotent Stem (iPS) Cells

Wednesday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne A/B


Wednesday, February 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Van Horne A/B


Thursday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Van Horne A/B


Thursday, February 28 | 8:00AM - 11:15AM
The Aging of Mitotic Cells
Room: Van Horne C

Speaker 1 of 7
* Alexandra Joyner, Memorial Sloan-Kettering Cancer Center, USA

Thursday, February 28 | 8:00AM - 11:15AM
The Aging of Mitotic Cells
Room: Van Horne C

Speaker 2 of 7
Andrew G. Dillin, University of California, Berkeley, USA
Protein Quality Control in Stem Cells and Aging

Thursday, February 28 | 8:00AM - 11:15AM
The Aging of Mitotic Cells
Room: Van Horne C

Speaker 3 of 7
Anne Brunet, Stanford University, USA
The Regulation of Stem Cell Aging

Thursday, February 28 | 8:00AM - 11:15AM
The Aging of Mitotic Cells
Room: Van Horne C

Speaker 4 of 7
Jan M. van Deursen, Mayo Clinic, USA
Stem and Progenitor Cell Senescence in Aging

Thursday, February 28 | 8:00AM - 11:15AM
The Aging of Mitotic Cells
Room: Van Horne C

Speaker 5 of 7
Norman E. Sharpless, NCI, National Institutes of Health, USA
Expression of Markers of Senescence, Aging and Self-Renewal

Thursday, February 28 | 8:00AM - 11:15AM
The Aging of Mitotic Cells
Room: Van Horne C

Speaker 6 of 7
Elizabeth A. Pollina, USA
Short Talk: Discovering Novel Regulators of Adult Neural Stem Cell Aging Using a Chromatin Signature

Thursday, February 28 | 8:00AM - 11:15AM
The Aging of Mitotic Cells
Room: Van Horne C

Speaker 7 of 7
Tohru Itoh, IMCB, University of Tokyo, Japan
Short Talk: FGF7 Is a Functional Niche Signal Required for Stimulation of Adult Liver Progenitor Cells that Support Liver Regeneration

Thursday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Thursday, February 28 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, February 28 | 3:00PM - 4:30PM
Workshop: Emerging Insights into Stem Cells and Niches

Speaker 1 of 5
* Iannis Aifantis, New York University School of Medicine, USA

Thursday, February 28 | 3:00PM - 4:30PM
Workshop: Emerging Insights into Stem Cells and Niches

Speaker 2 of 5
Eirini P. Papapetrou, Icahn School of Medicine at Mount Sinai, USA
Modeling Myelodysplasia Using Human Pluripotent Stem Cells

Thursday, February 28 | 3:00PM - 4:30PM
Workshop: Emerging Insights into Stem Cells and Niches

Speaker 3 of 5
Gabrielle Kardon, University of Utah, USA
Wnt/beta-Catenin Signaling Is Active, But Not Required for Stem Cell Function during Muscle Regeneration

Thursday, February 28 | 3:00PM - 4:30PM
Workshop: Emerging Insights into Stem Cells and Niches

Speaker 4 of 5
E. Camilla Forsberg, University of California, Santa Cruz, USA
Robo4-Mediated Vascular Integrity Promotes Hematopoietic Stem Cell Engraftment

Thursday, February 28 | 3:00PM - 4:30PM
Workshop: Emerging Insights into Stem Cells and Niches

Speaker 5 of 5
Valentina Greco, Yale School of Medicine, USA
Cellular and Signaling Mechanisms that Regulate
Hair Follicle Stem Cells by Live Imaging


Thursday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, February 28 | 5:00PM - 7:00PM
Self-Renewal Pathways and Disease
Room: Van Horne C

Speaker 1 of 5
* Norman E. Sharpless, NCI, National Institutes of Health, USA

Thursday, February 28 | 5:00PM - 7:00PM
Self-Renewal Pathways and Disease
Room: Van Horne C

Speaker 2 of 5
Alexandra Joyner, Memorial Sloan-Kettering Cancer Center, USA
Differential Regulation of Adult Stem Cells by Sonic Hedgehog Signaling

Thursday, February 28 | 5:00PM - 7:00PM
Self-Renewal Pathways and Disease
Room: Van Horne C

Speaker 3 of 5
Fernando D. Camargo, Boston Children's Hospital, USA
Hippo/YAP Signaling in Stem Cells, Regeneration and Cancer

Thursday, February 28 | 5:00PM - 7:00PM
Self-Renewal Pathways and Disease
Room: Van Horne C

Speaker 4 of 5
Kai Kessenbrock, University of California, Irvine, USA
Short Talk: A Novel Role for Matrix Metalloproteinases In Regulating Mammary Stem Cell Function via the Wnt Signaling Pathway

Thursday, February 28 | 5:00PM - 7:00PM
Self-Renewal Pathways and Disease
Room: Van Horne C

Speaker 5 of 5
Ulrich Steidl, Albert Einstein College of Medicine, USA
Short Talk: Special AT-Rich Sequence-Binding Protein 1 (Satb1) Regulates Hematopoietic Stem Cell Fate

Thursday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Van Horne A/B


Thursday, February 28 | 8:00PM - 11:00PM
Entertainment
Room: Van Horne A/B


Thursday, February 28 | 8:00PM - 11:00PM
Cash Bar
Room: Van Horne A/B


Friday, March 01 | 10:25AM - 10:25AM
Departure


*Session Chair.