Web Desc
Structural Analysis of Supramolecular Assemblies by Hybrid Methods
Organizer(s): Andrej Sali, Brian T. Chait and David Baker
Date: March 03 - 07, 2013
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by the Directors' Fund
Summary of Meeting:
In order to understand the workings of a living cell, we need to know the structures and dynamics of individual biological macromolecules, their complexes and networks, organelles and whole cells, thus interfacing structural biology with cell biology, systems biology, proteomics, chemical biology and biophysics. The accuracy, precision, completeness and efficiency of structural characterization are maximized by hybrid or integrative approaches that combine data from multiple types of experimental methods through the use of computational analysis and modeling methods. These experimental methods include X-ray crystallography, NMR spectroscopy, electron microscopy, small angle X-ray scattering, mass spectrometry, chemical cross-linking, super-high resolution optical microscopy, optical microscopy and others. The goal of this meeting is to highlight the strengths and limitations of the current hybrid approaches as well as to identify promising new advances in experimental methods for collecting the data and computational methods for converting the data to models. Finally, hybrid approaches will be demonstrated by their applications to important and challenging biological problems, spanning a wide range of length and time scales, from atomic structures of individual proteins to low-resolution representations of whole cells.
Scholarship Deadline: November 5 2012
Discounted Abstract Deadline: November 5 2012
Abstract Deadline: December 3 2012
Discounted Registration Deadline: December 19 2012
We gratefully acknowledge additional support for this conference from:
Landes Bioscience
Rigaku Americas Corporation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Max Planck Institute of Biochemistry

University of California, San Francisco
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM105010-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 03 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function


Sunday, March 03 | 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall


Monday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, March 04 | 8:00AM - 9:00AM
Opening Remarks and Keynote Address
Room: Mountain/Lake

Speaker 1 of 4
* Andrej Sali, University of California, San Francisco, USA

Monday, March 04 | 8:00AM - 9:00AM
Opening Remarks and Keynote Address
Room: Mountain/Lake

Speaker 2 of 4
* David Baker, University of Washington, USA

Monday, March 04 | 8:00AM - 9:00AM
Opening Remarks and Keynote Address
Room: Mountain/Lake

Speaker 3 of 4
* Brian T. Chait, Rockefeller University, USA

Monday, March 04 | 8:00AM - 9:00AM
Opening Remarks and Keynote Address
Room: Mountain/Lake

Speaker 4 of 4
Peter Walter, HHMI/University of California, San Francisco, USA
The Unfolded Protein Response in Health and Disease

Monday, March 04 | 9:00AM - 12:00PM
Computation for Hybrid Approaches
Room: Mountain/Lake
This session will introduce major challenges in structural modeling of biological systems at different resolutions, from atomic to cellular, based on varied experimental datasets. Such challenges include representing the system, converting data into scoring functions, finding good scoring solutions, and analysing the results.
Speaker 1 of 6
* Ian A. Wilson, The Scripps Research Institute, USA

Monday, March 04 | 9:00AM - 12:00PM
Computation for Hybrid Approaches
Room: Mountain/Lake
This session will introduce major challenges in structural modeling of biological systems at different resolutions, from atomic to cellular, based on varied experimental datasets. Such challenges include representing the system, converting data into scoring functions, finding good scoring solutions, and analysing the results.
Speaker 2 of 6
Andrej Sali, University of California, San Francisco, USA
Integrative Structure Determination of Macromolecular Assemblies

Monday, March 04 | 9:00AM - 12:00PM
Computation for Hybrid Approaches
Room: Mountain/Lake
This session will introduce major challenges in structural modeling of biological systems at different resolutions, from atomic to cellular, based on varied experimental datasets. Such challenges include representing the system, converting data into scoring functions, finding good scoring solutions, and analysing the results.
Speaker 3 of 6
David Baker, University of Washington, USA
Computation of Protein Structures from Sparse NMR Data and Low Resolution X-Ray Data

Monday, March 04 | 9:00AM - 12:00PM
Computation for Hybrid Approaches
Room: Mountain/Lake
This session will introduce major challenges in structural modeling of biological systems at different resolutions, from atomic to cellular, based on varied experimental datasets. Such challenges include representing the system, converting data into scoring functions, finding good scoring solutions, and analysing the results.
Speaker 4 of 6
Nikolaos G. Sgourakis, University of California, Santa Cruz, USA
Short Talk: Advances in Structure Determination of Multimeric Protein Assemblies using NMR and cryoEM Data

Monday, March 04 | 9:00AM - 12:00PM
Computation for Hybrid Approaches
Room: Mountain/Lake
This session will introduce major challenges in structural modeling of biological systems at different resolutions, from atomic to cellular, based on varied experimental datasets. Such challenges include representing the system, converting data into scoring functions, finding good scoring solutions, and analysing the results.
Speaker 5 of 6
Gregory A. Voth, University of Chicago, USA
Hybrid Multiscale Modeling of Biological Macromolecules and Macromolecular Assemblies

Monday, March 04 | 9:00AM - 12:00PM
Computation for Hybrid Approaches
Room: Mountain/Lake
This session will introduce major challenges in structural modeling of biological systems at different resolutions, from atomic to cellular, based on varied experimental datasets. Such challenges include representing the system, converting data into scoring functions, finding good scoring solutions, and analysing the results.
Speaker 6 of 6
Zaida (Zan) Luthey-Schulten, University of Illinois at Urbana-Champaign, USA
Whole Cell Simulations

Monday, March 04 | 9:40AM - 10:00AM
Coffee Break
Room: Pre Function


Monday, March 04 | 12:00PM - 1:00PM
Poster Setup
Room: Bay


Monday, March 04 | 12:00PM - 4:30PM
On Own for Lunch and Recreation


Monday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, March 04 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, March 04 | 5:00PM - 7:00PM
Hybrid Approaches to Studying Dynamic Systems
Room: Mountain/Lake
This session will highlight successes and challenges in using hybrid methods to describe the dynamics of individual macromolecules and their assemblies. Presentations will motivate further method development by the needs of structural biologists interested in specific systems.
Speaker 1 of 5
* Alasdair C. Steven, NIAMS, National Institutes of Health, USA

Monday, March 04 | 5:00PM - 7:00PM
Hybrid Approaches to Studying Dynamic Systems
Room: Mountain/Lake
This session will highlight successes and challenges in using hybrid methods to describe the dynamics of individual macromolecules and their assemblies. Presentations will motivate further method development by the needs of structural biologists interested in specific systems.
Speaker 2 of 5
James R. Williamson, The Scripps Research Institute, USA
Hybrid Methods for Study of Ribosome Assembly in Bacterial Cells

Monday, March 04 | 5:00PM - 7:00PM
Hybrid Approaches to Studying Dynamic Systems
Room: Mountain/Lake
This session will highlight successes and challenges in using hybrid methods to describe the dynamics of individual macromolecules and their assemblies. Presentations will motivate further method development by the needs of structural biologists interested in specific systems.
Speaker 3 of 5
Bo Huang, University of California, San Francisco, USA
Dissecting Molecular Complex Architecture by Super-Resolution Microscopy

Monday, March 04 | 5:00PM - 7:00PM
Hybrid Approaches to Studying Dynamic Systems
Room: Mountain/Lake
This session will highlight successes and challenges in using hybrid methods to describe the dynamics of individual macromolecules and their assemblies. Presentations will motivate further method development by the needs of structural biologists interested in specific systems.
Speaker 4 of 5
Timothy O. Street, University of California, San Francisco, USA
Short Talk: The Mechanism of the Hsp90 Chaperonin Revealed by Hybrid Methods

Monday, March 04 | 5:00PM - 7:00PM
Hybrid Approaches to Studying Dynamic Systems
Room: Mountain/Lake
This session will highlight successes and challenges in using hybrid methods to describe the dynamics of individual macromolecules and their assemblies. Presentations will motivate further method development by the needs of structural biologists interested in specific systems.
Speaker 5 of 5
Klaus J. Schulten, University of Illinois at Urbana-Champaign, USA
Solving Large Structures by Molecular Dynamics Flexible Fitting

Monday, March 04 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, March 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay


Monday, March 04 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Tuesday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, March 05 | 8:00AM - 11:15AM
Hybrid Approaches to Studying Macromolecular Structures
Room: Mountain/Lake
This session will highlight successes and challenges in using hybrid methods to describe the structures of individual macromolecules and their assemblies. Presentations will motivate further method development by the needs of structural biologists interested in specific systems.
Speaker 1 of 7
* David Baker, University of Washington, USA

Tuesday, March 05 | 8:00AM - 11:15AM
Hybrid Approaches to Studying Macromolecular Structures
Room: Mountain/Lake
This session will highlight successes and challenges in using hybrid methods to describe the structures of individual macromolecules and their assemblies. Presentations will motivate further method development by the needs of structural biologists interested in specific systems.
Speaker 2 of 7
Ian A. Wilson, The Scripps Research Institute, USA
Hybrid Approaches to Antibody-Virus Systems

Tuesday, March 05 | 8:00AM - 11:15AM
Hybrid Approaches to Studying Macromolecular Structures
Room: Mountain/Lake
This session will highlight successes and challenges in using hybrid methods to describe the structures of individual macromolecules and their assemblies. Presentations will motivate further method development by the needs of structural biologists interested in specific systems.
Speaker 3 of 7
Holger Stark, Max Planck Institute for Biophysical Chemistry, Germany
Combining Cryo-EM, X-Ray and MD Simulations to Study Dynamic Macromolecular Complexes

Tuesday, March 05 | 8:00AM - 11:15AM
Hybrid Approaches to Studying Macromolecular Structures
Room: Mountain/Lake
This session will highlight successes and challenges in using hybrid methods to describe the structures of individual macromolecules and their assemblies. Presentations will motivate further method development by the needs of structural biologists interested in specific systems.
Speaker 4 of 7
Alasdair C. Steven, NIAMS, National Institutes of Health, USA
Novel Fold and Maturation Dynamics of a dsRNA Virus Capsid Protein

Tuesday, March 05 | 8:00AM - 11:15AM
Hybrid Approaches to Studying Macromolecular Structures
Room: Mountain/Lake
This session will highlight successes and challenges in using hybrid methods to describe the structures of individual macromolecules and their assemblies. Presentations will motivate further method development by the needs of structural biologists interested in specific systems.
Speaker 5 of 7
Eva Nogales, University of California, Berkeley, USA
Cryo-EM and Computation toward a Mechanistic Understanding of Microtubule Dynamic Instability

Tuesday, March 05 | 8:00AM - 11:15AM
Hybrid Approaches to Studying Macromolecular Structures
Room: Mountain/Lake
This session will highlight successes and challenges in using hybrid methods to describe the structures of individual macromolecules and their assemblies. Presentations will motivate further method development by the needs of structural biologists interested in specific systems.
Speaker 6 of 7
Mary E. Matyskiela, University of California, Berkeley, USA
Short Talk: Molecular Mechanisms of Substrate Degradation by the 26S Proteasome Revealed by CryoEM

Tuesday, March 05 | 8:00AM - 11:15AM
Hybrid Approaches to Studying Macromolecular Structures
Room: Mountain/Lake
This session will highlight successes and challenges in using hybrid methods to describe the structures of individual macromolecules and their assemblies. Presentations will motivate further method development by the needs of structural biologists interested in specific systems.
Speaker 7 of 7
Helen M. Berman, Rutgers University, Center for Proteomics Research, USA
Short Talk: The Protein Model Portal – A Comprehensive Web Resource For Protein Structure Information

Tuesday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, March 05 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, March 05 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Tuesday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, March 05 | 2:30PM - 3:30PM
Panel 1: Key Issues in Measuring, Computing, Analyzing, Visu
alizing, Archiving, and Disseminating Hybrid Models
Room: Mountain/Lake
The panel members will be asked to discuss their key issues in hybrid methods (e.g., key issues and challenges in collecting and interpreting structural data; hybrid model computation; reproducibility of computing hybrid models; representations for data and hybrid models; visualization of hybrid models; role of the PDB in hybrid models; role of journals / funding agencies in hybrid models). If useful conclusions emerge, they will be included in the commentary on the meeting to be published in the journal Structure.
Speaker 1 of 6
* Andrej Sali, University of California, San Francisco, USA

Tuesday, March 05 | 2:30PM - 3:30PM
Panel 1: Key Issues in Measuring, Computing, Analyzing, Visu
alizing, Archiving, and Disseminating Hybrid Models
Room: Mountain/Lake
The panel members will be asked to discuss their key issues in hybrid methods (e.g., key issues and challenges in collecting and interpreting structural data; hybrid model computation; reproducibility of computing hybrid models; representations for data and hybrid models; visualization of hybrid models; role of the PDB in hybrid models; role of journals / funding agencies in hybrid models). If useful conclusions emerge, they will be included in the commentary on the meeting to be published in the journal Structure.
Speaker 2 of 6
Frank Alber, University California, Los Angeles, USA

Tuesday, March 05 | 2:30PM - 3:30PM
Panel 1: Key Issues in Measuring, Computing, Analyzing, Visu
alizing, Archiving, and Disseminating Hybrid Models
Room: Mountain/Lake
The panel members will be asked to discuss their key issues in hybrid methods (e.g., key issues and challenges in collecting and interpreting structural data; hybrid model computation; reproducibility of computing hybrid models; representations for data and hybrid models; visualization of hybrid models; role of the PDB in hybrid models; role of journals / funding agencies in hybrid models). If useful conclusions emerge, they will be included in the commentary on the meeting to be published in the journal Structure.
Speaker 3 of 6
David Baker, University of Washington, USA

Tuesday, March 05 | 2:30PM - 3:30PM
Panel 1: Key Issues in Measuring, Computing, Analyzing, Visu
alizing, Archiving, and Disseminating Hybrid Models
Room: Mountain/Lake
The panel members will be asked to discuss their key issues in hybrid methods (e.g., key issues and challenges in collecting and interpreting structural data; hybrid model computation; reproducibility of computing hybrid models; representations for data and hybrid models; visualization of hybrid models; role of the PDB in hybrid models; role of journals / funding agencies in hybrid models). If useful conclusions emerge, they will be included in the commentary on the meeting to be published in the journal Structure.
Speaker 4 of 6
Alasdair C. Steven, NIAMS, National Institutes of Health, USA

Tuesday, March 05 | 2:30PM - 3:30PM
Panel 1: Key Issues in Measuring, Computing, Analyzing, Visu
alizing, Archiving, and Disseminating Hybrid Models
Room: Mountain/Lake
The panel members will be asked to discuss their key issues in hybrid methods (e.g., key issues and challenges in collecting and interpreting structural data; hybrid model computation; reproducibility of computing hybrid models; representations for data and hybrid models; visualization of hybrid models; role of the PDB in hybrid models; role of journals / funding agencies in hybrid models). If useful conclusions emerge, they will be included in the commentary on the meeting to be published in the journal Structure.
Speaker 5 of 6
Gregory A. Voth, University of Chicago, USA

Tuesday, March 05 | 2:30PM - 3:30PM
Panel 1: Key Issues in Measuring, Computing, Analyzing, Visu
alizing, Archiving, and Disseminating Hybrid Models
Room: Mountain/Lake
The panel members will be asked to discuss their key issues in hybrid methods (e.g., key issues and challenges in collecting and interpreting structural data; hybrid model computation; reproducibility of computing hybrid models; representations for data and hybrid models; visualization of hybrid models; role of the PDB in hybrid models; role of journals / funding agencies in hybrid models). If useful conclusions emerge, they will be included in the commentary on the meeting to be published in the journal Structure.
Speaker 6 of 6
Ian A. Wilson, The Scripps Research Institute, USA

Tuesday, March 05 | 3:30PM - 4:30PM
Panel 2: Reproducibility and Publishing of Hybrid Models
Room: Mountain/Lake
The goal of the workshop panel is to present and discuss guidelines and principles for publishing reproducible hybrid-computational protocols and workflows. Current standards and practices for publishing complex hybrid-computational workflows are insufficient to ensure reproducibility of published findings and promote adoption and adaption of hybrid-computational methods among scientists. Authors, publishers, funders and developers each have an important role to play in helping ensure the reproducibility, widespread adoption and utility of hybrid-computational methods.
Speaker 1 of 5
* Andrew Morin, Harvard Medical School, USA

Tuesday, March 05 | 3:30PM - 4:30PM
Panel 2: Reproducibility and Publishing of Hybrid Models
Room: Mountain/Lake
The goal of the workshop panel is to present and discuss guidelines and principles for publishing reproducible hybrid-computational protocols and workflows. Current standards and practices for publishing complex hybrid-computational workflows are insufficient to ensure reproducibility of published findings and promote adoption and adaption of hybrid-computational methods among scientists. Authors, publishers, funders and developers each have an important role to play in helping ensure the reproducibility, widespread adoption and utility of hybrid-computational methods.
Speaker 2 of 5
Helen M. Berman, Rutgers University, Center for Proteomics Research, USA

Tuesday, March 05 | 3:30PM - 4:30PM
Panel 2: Reproducibility and Publishing of Hybrid Models
Room: Mountain/Lake
The goal of the workshop panel is to present and discuss guidelines and principles for publishing reproducible hybrid-computational protocols and workflows. Current standards and practices for publishing complex hybrid-computational workflows are insufficient to ensure reproducibility of published findings and promote adoption and adaption of hybrid-computational methods among scientists. Authors, publishers, funders and developers each have an important role to play in helping ensure the reproducibility, widespread adoption and utility of hybrid-computational methods.
Speaker 3 of 5
Ines Chen, Springer Nature, USA

Tuesday, March 05 | 3:30PM - 4:30PM
Panel 2: Reproducibility and Publishing of Hybrid Models
Room: Mountain/Lake
The goal of the workshop panel is to present and discuss guidelines and principles for publishing reproducible hybrid-computational protocols and workflows. Current standards and practices for publishing complex hybrid-computational workflows are insufficient to ensure reproducibility of published findings and promote adoption and adaption of hybrid-computational methods among scientists. Authors, publishers, funders and developers each have an important role to play in helping ensure the reproducibility, widespread adoption and utility of hybrid-computational methods.
Speaker 4 of 5
Daniel Russel, University of California, San Francisco, USA

Tuesday, March 05 | 3:30PM - 4:30PM
Panel 2: Reproducibility and Publishing of Hybrid Models
Room: Mountain/Lake
The goal of the workshop panel is to present and discuss guidelines and principles for publishing reproducible hybrid-computational protocols and workflows. Current standards and practices for publishing complex hybrid-computational workflows are insufficient to ensure reproducibility of published findings and promote adoption and adaption of hybrid-computational methods among scientists. Authors, publishers, funders and developers each have an important role to play in helping ensure the reproducibility, widespread adoption and utility of hybrid-computational methods.
Speaker 5 of 5
Klaus J. Schulten, University of Illinois at Urbana-Champaign, USA

Tuesday, March 05 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, March 05 | 5:00PM - 7:15PM
Hybrid Approaches to Studying Cellular Organization
Room: Mountain/Lake
This session will highlight approaches, tools, successes and challenges in using hybrid methods to describe the organization of whole cells.
Speaker 1 of 5
* James R. Williamson, The Scripps Research Institute, USA

Tuesday, March 05 | 5:00PM - 7:15PM
Hybrid Approaches to Studying Cellular Organization
Room: Mountain/Lake
This session will highlight approaches, tools, successes and challenges in using hybrid methods to describe the organization of whole cells.
Speaker 2 of 5
Benjamin Geiger, Weizmann Institute of Science, Israel
Supramolecular Structures Involved in the Scaffolding and Signaling Processes in Focal Adhesions

Tuesday, March 05 | 5:00PM - 7:15PM
Hybrid Approaches to Studying Cellular Organization
Room: Mountain/Lake
This session will highlight approaches, tools, successes and challenges in using hybrid methods to describe the organization of whole cells.
Speaker 3 of 5
Frank Alber, University California, Los Angeles, USA
Exploring Parallel Genome Universes

Tuesday, March 05 | 5:00PM - 7:15PM
Hybrid Approaches to Studying Cellular Organization
Room: Mountain/Lake
This session will highlight approaches, tools, successes and challenges in using hybrid methods to describe the organization of whole cells.
Speaker 4 of 5
Graham T. Johnson, University of California, San Francisco, USA
cellPack: A Virtual Mesoscope to Model and Visualize Structural Systems Biology

Tuesday, March 05 | 5:00PM - 7:15PM
Hybrid Approaches to Studying Cellular Organization
Room: Mountain/Lake
This session will highlight approaches, tools, successes and challenges in using hybrid methods to describe the organization of whole cells.
Speaker 5 of 5
Wolfgang P. Baumeister, Max Planck Institute of Biochemistry, Germany
Structure of the 26S Proteasome Holocomplex Determined by an Integrative Approach

Tuesday, March 05 | 7:15PM - 8:15PM
Dinner
Room: Granhall


Tuesday, March 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay


Tuesday, March 05 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Wednesday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, March 06 | 8:00AM - 11:15AM
Single Molecule Methods
Room: Mountain/Lake
This session will focus on computational and experimental methods for studying single molecules, to localize them in the cell, position them with respect to other structures in the cell, and in particular to describe their dynamics. The methods will be illustrated by their application to specific biological systems.
Speaker 1 of 7
* Eva Nogales, University of California, Berkeley, USA

Wednesday, March 06 | 8:00AM - 11:15AM
Single Molecule Methods
Room: Mountain/Lake
This session will focus on computational and experimental methods for studying single molecules, to localize them in the cell, position them with respect to other structures in the cell, and in particular to describe their dynamics. The methods will be illustrated by their application to specific biological systems.
Speaker 2 of 7
Stefan W. Hell, Max Planck Institute for Biophysical Chemistry, Germany
Nanoscopy with Focused Light

Wednesday, March 06 | 8:00AM - 11:15AM
Single Molecule Methods
Room: Mountain/Lake
This session will focus on computational and experimental methods for studying single molecules, to localize them in the cell, position them with respect to other structures in the cell, and in particular to describe their dynamics. The methods will be illustrated by their application to specific biological systems.
Speaker 3 of 7
Joseph D. Puglisi, Stanford University, USA
Hybrid Studies of the Ribosome Function

Wednesday, March 06 | 8:00AM - 11:15AM
Single Molecule Methods
Room: Mountain/Lake
This session will focus on computational and experimental methods for studying single molecules, to localize them in the cell, position them with respect to other structures in the cell, and in particular to describe their dynamics. The methods will be illustrated by their application to specific biological systems.
Speaker 4 of 7
Scott C. Blanchard, Weill Cornell Medicine, USA
Allosteric Control of the Ribosome by Small-Molecule Antibiotics

Wednesday, March 06 | 8:00AM - 11:15AM
Single Molecule Methods
Room: Mountain/Lake
This session will focus on computational and experimental methods for studying single molecules, to localize them in the cell, position them with respect to other structures in the cell, and in particular to describe their dynamics. The methods will be illustrated by their application to specific biological systems.
Speaker 5 of 7
Yujie Sun, Biodynamic Optical Imaging Center, China
Allostery Revisited

Wednesday, March 06 | 8:00AM - 11:15AM
Single Molecule Methods
Room: Mountain/Lake
This session will focus on computational and experimental methods for studying single molecules, to localize them in the cell, position them with respect to other structures in the cell, and in particular to describe their dynamics. The methods will be illustrated by their application to specific biological systems.
Speaker 6 of 7
Alexander Leitner, ETH Zurich, Switzerland
Short Talk: Generating Spatial Restraints with an Integrated Chemical Cross-Linking-Mass Spectrometry Platform and their Use in Hybrid Methods

Wednesday, March 06 | 8:00AM - 11:15AM
Single Molecule Methods
Room: Mountain/Lake
This session will focus on computational and experimental methods for studying single molecules, to localize them in the cell, position them with respect to other structures in the cell, and in particular to describe their dynamics. The methods will be illustrated by their application to specific biological systems.
Speaker 7 of 7
Robin E. Stanley, NIEHS, National Institutes of Health, USA
Short Talk: Architecture of the Atg17 Complex as a Scaffold for Autophagosome Biogenesis

Wednesday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, March 06 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Wednesday, March 06 | 2:30PM - 4:30PM
Workshop: Software for Integrative Structure Determination
Room: Mountain/Lake
This workshop will include brief tutorials of software packages useful in building hybrid models. The functionality and scope of the packages will be outlined.
Speaker 1 of 6
* Klaus J. Schulten, University of Illinois at Urbana-Champaign, USA

Wednesday, March 06 | 2:30PM - 4:30PM
Workshop: Software for Integrative Structure Determination
Room: Mountain/Lake
This workshop will include brief tutorials of software packages useful in building hybrid models. The functionality and scope of the packages will be outlined.
Speaker 2 of 6
Yifan Song, University of Washington, USA
High-Resolution Comparative Modeling with RosettaCM

Wednesday, March 06 | 2:30PM - 4:30PM
Workshop: Software for Integrative Structure Determination
Room: Mountain/Lake
This workshop will include brief tutorials of software packages useful in building hybrid models. The functionality and scope of the packages will be outlined.
Speaker 3 of 6
Corey F. Hryc, Baylor College of Medicine, USA
EMAN and Pathwalker

Wednesday, March 06 | 2:30PM - 4:30PM
Workshop: Software for Integrative Structure Determination
Room: Mountain/Lake
This workshop will include brief tutorials of software packages useful in building hybrid models. The functionality and scope of the packages will be outlined.
Speaker 4 of 6
Robert Paul Rambo, Lawrence Berkeley National Laboratory, USA
SAXS Suite at LBNL

Wednesday, March 06 | 2:30PM - 4:30PM
Workshop: Software for Integrative Structure Determination
Room: Mountain/Lake
This workshop will include brief tutorials of software packages useful in building hybrid models. The functionality and scope of the packages will be outlined.
Speaker 5 of 6
Juan R. Perilla, University of Illinois Urbana-Champaign, USA
VMD

Wednesday, March 06 | 2:30PM - 4:30PM
Workshop: Software for Integrative Structure Determination
Room: Mountain/Lake
This workshop will include brief tutorials of software packages useful in building hybrid models. The functionality and scope of the packages will be outlined.
Speaker 6 of 6
Daniel Russel, University of California, San Francisco, USA
IMP

Wednesday, March 06 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, March 06 | 5:00PM - 7:00PM
Latest Advances in Hybrid Methods
Room: Mountain/Lake
This session will present recent methodological advances in hybrid approaches as well as in individual methods for structure and dynamics characterization that can be incorporated into hybrid approaches.
Speaker 1 of 4
* Brian T. Chait, Rockefeller University, USA
Mass Spectrometry and Proteomics for Hybrid Structure Determination

Wednesday, March 06 | 5:00PM - 7:00PM
Latest Advances in Hybrid Methods
Room: Mountain/Lake
This session will present recent methodological advances in hybrid approaches as well as in individual methods for structure and dynamics characterization that can be incorporated into hybrid approaches.
Speaker 2 of 4
Carolyn A. Larabell, University of California, San Francisco, USA
Correlated Fluorescence and X-Ray Tomography of Intact Cells

Wednesday, March 06 | 5:00PM - 7:00PM
Latest Advances in Hybrid Methods
Room: Mountain/Lake
This session will present recent methodological advances in hybrid approaches as well as in individual methods for structure and dynamics characterization that can be incorporated into hybrid approaches.
Speaker 3 of 4
Yifan Cheng, University of California, San Francisco, USA
Short Talk: A New Electron Counting CMOS Camera Enables Routine Near Atomic Resolution Single Particle cryoEM

Wednesday, March 06 | 5:00PM - 7:00PM
Latest Advances in Hybrid Methods
Room: Mountain/Lake
This session will present recent methodological advances in hybrid approaches as well as in individual methods for structure and dynamics characterization that can be incorporated into hybrid approaches.
Speaker 4 of 4
Michael Nilges, Institut Pasteur, France
Inferential Structure Determination from Hybrid Data

Wednesday, March 06 | 7:00PM - 7:15PM
Closing Remarks

Speaker 1 of 3
Andrej Sali, University of California, San Francisco, USA

Wednesday, March 06 | 7:00PM - 7:15PM
Closing Remarks

Speaker 2 of 3
David Baker, University of Washington, USA

Wednesday, March 06 | 7:00PM - 7:15PM
Closing Remarks

Speaker 3 of 3
Brian T. Chait, Rockefeller University, USA

Wednesday, March 06 | 7:15PM - 8:15PM
Dinner
Room: Granhall


Wednesday, March 06 | 7:15PM - 8:15PM
Social Hour
Room: Granhall


Wednesday, March 06 | 8:00PM - 11:00PM
Entertainment
Room: Granhall


Wednesday, March 06 | 8:15PM - 11:00PM
Cash Bar
Room: Granhall


Thursday, March 07 | 10:25AM - 10:25AM
Departure


*Session Chair.