Web Desc
Growing to Extremes: Cell Biology and Pathology of Axons
Organizer(s): Valeria Cavalli, Michael Fainzilber and Jeffery L. Twiss
Date: March 10 - 15, 2013
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by the Directors' Fund
Summary of Meeting:
Neuronal communication is essential for every movement, sensation and thought in motile animals, and the axonal extensions of neurons provide all long-range communication to, from, and within the brain and spinal cord. Axons extend distances ranging from hundreds of microns to more than a meter in humans, lengths that both require specialized mechanisms for formation and maintenance, and increase the risk of degeneration and dysfunction upon injury or disease. Thus, diverse communities of basic researchers and clinicians must address problems rooted in axonal cell biology, but to date there is no meeting that serves as a central venue for this field. Axon biology meetings in the past have focused on specific sub-topics such as axon guidance, trophic factors, or neurodegeneration. This meeting will bring together the multiple disciplines required for accelerating progress in the field of axonal biology and pathology, providing a unique venue to bring together basic research on molecular and cellular biology of axons with clinical needs and industry interest. The conference will cover a broad spectrum of the latest developments in molecular and cellular axonal research, from development and maintenance, through to survival and repair, in both the central and peripheral nervous systems. Additional topics and late-breaking developments will be incorporated via talks selected from abstracts, specifically encouraging participation of junior researchers and those new to the field. The multidisciplinary theme and shared focus will facilitate communication across the entire continuum from basic to clinical neuroscience.
Scholarship Deadline: November 8 2012
Discounted Abstract Deadline: November 8 2012
Abstract Deadline: December 10 2012
Discounted Registration Deadline: January 10 2013
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS082038-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 10 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function


Sunday, March 10 | 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall


Sunday, March 10 | 6:00PM - 9:00PM
Welcome Mixer
Room: Granhall
Drinks available for purchase.

Monday, March 11 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, March 11 | 8:00AM - 11:15AM
Axonal Specification, Cytoskeleton and Compartmentalization
Room: Mountain/Lake

Speaker 1 of 8
* Valeria Cavalli, Washington University, USA

Monday, March 11 | 8:00AM - 11:15AM
Axonal Specification, Cytoskeleton and Compartmentalization
Room: Mountain/Lake

Speaker 2 of 8
Frank Bradke, German Center for Neurodegenerative Diseases, Germany
Brain Penetrant Epothilone Reduces Scarring and Induces Axon Growth after Spinal Cord Injury

Monday, March 11 | 8:00AM - 11:15AM
Axonal Specification, Cytoskeleton and Compartmentalization
Room: Mountain/Lake

Speaker 3 of 8
Matthew N. Rasband, Baylor College of Medicine, USA
The Axon Initial Segment (AIS) and Nodes of Ranvier are Essential for Action Potential Initiation and Propagation

Monday, March 11 | 8:00AM - 11:15AM
Axonal Specification, Cytoskeleton and Compartmentalization
Room: Mountain/Lake

Speaker 4 of 8
Caterina Tomba, Institut Néel - CNRS, France
Short Talk: Actin Waves in Developing Neurons: Shapes, Mechanical Regulations and Axonal Polarization

Monday, March 11 | 8:00AM - 11:15AM
Axonal Specification, Cytoskeleton and Compartmentalization
Room: Mountain/Lake

Speaker 5 of 8
* Niels Galjart, Erasmus MC, Netherlands

Monday, March 11 | 8:00AM - 11:15AM
Axonal Specification, Cytoskeleton and Compartmentalization
Room: Mountain/Lake

Speaker 6 of 8
Franck Polleux, Columbia University, Mortimer B. Zuckerman Mind Brain Behavior Institute, USA
LKB1-NUAK1 Kinase Pathway Controls Axon Branching in vivo through Regulation of Presynaptic Mitochondrial Capture

Monday, March 11 | 8:00AM - 11:15AM
Axonal Specification, Cytoskeleton and Compartmentalization
Room: Mountain/Lake

Speaker 7 of 8
Kozo Kaibuchi, Nagoya University Graduate School of Medicine, Japan
Neuronal Polarity in vitro and in vivo

Monday, March 11 | 8:00AM - 11:15AM
Axonal Specification, Cytoskeleton and Compartmentalization
Room: Mountain/Lake

Speaker 8 of 8
Pei-Lin Cheng, Academia Sinica, Taiwan
Short Talk: Directional Axoplasmic Transport of Proteasome in Neuronal Polarization

Monday, March 11 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Monday, March 11 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Monday, March 11 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, March 11 | 5:00PM - 7:00PM
Axonal Growth Modalities
Room: Mountain/Lake

Speaker 1 of 5
* Nathalie Lamarche-Vane, McGill University-RI-MUHC, Canada

Monday, March 11 | 5:00PM - 7:00PM
Axonal Growth Modalities
Room: Mountain/Lake

Speaker 2 of 5
Michael Fainzilber, Weizmann Institute of Science, Israel
Intrinsic Mechanisms of Axon Growth Control

Monday, March 11 | 5:00PM - 7:00PM
Axonal Growth Modalities
Room: Mountain/Lake

Speaker 3 of 5
Douglas H. Smith, University of Pennsylvania, USA
Tension is Good for your Nerves

Monday, March 11 | 5:00PM - 7:00PM
Axonal Growth Modalities
Room: Mountain/Lake

Speaker 4 of 5
Giampietro Schiavo, University College London, UK
BICD1 Regulates the Intracellular Sorting and Signaling of Neurotrophin Receptors

Monday, March 11 | 5:00PM - 7:00PM
Axonal Growth Modalities
Room: Mountain/Lake

Speaker 5 of 5
Mónica M. Sousa, i3S, Portugal
Short Talk: Increased Axonal Transport following Conditioning Lesion Underlies Gain of Axonal Regenerative Capacity

Monday, March 11 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, March 11 | 7:00PM - 8:00PM
Social Hour
Room: Granhall


Tuesday, March 12 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, March 12 | 8:00AM - 11:15AM
Molecular Motors and Axonal Transport Regulation
Room: Mountain/Lake

Speaker 1 of 8
* Viki J. Allan, University of Manchester, UK

Tuesday, March 12 | 8:00AM - 11:15AM
Molecular Motors and Axonal Transport Regulation
Room: Mountain/Lake

Speaker 2 of 8
Richard Vallee, Columbia University, USA
Regulation of Cytoplasmic Dynein Transport

Tuesday, March 12 | 8:00AM - 11:15AM
Molecular Motors and Axonal Transport Regulation
Room: Mountain/Lake

Speaker 3 of 8
Erika L. F. Holzbaur, University of Pennsylvania, USA
Initiation and Regulation of Axonal Transport: Mechanisms of Motor Engagement and Motor Coordination

Tuesday, March 12 | 8:00AM - 11:15AM
Molecular Motors and Axonal Transport Regulation
Room: Mountain/Lake

Speaker 4 of 8
Chen Gu, Ohio State University, USA
Short Talk: Activation of Conventional Kinesin Motors in Clusters by Shaw Voltage-Gated Potassium Channels

Tuesday, March 12 | 8:00AM - 11:15AM
Molecular Motors and Axonal Transport Regulation
Room: Mountain/Lake

Speaker 5 of 8
* Caitlin E. Hill, Weill Medical College of Cornell University, USA

Tuesday, March 12 | 8:00AM - 11:15AM
Molecular Motors and Axonal Transport Regulation
Room: Mountain/Lake

Speaker 6 of 8
Valeria Cavalli, Washington University, USA
Dual Role of HDAC5 in the Regulation of Axon Growth and Regeneration


Tuesday, March 12 | 8:00AM - 11:15AM
Molecular Motors and Axonal Transport Regulation
Room: Mountain/Lake

Speaker 7 of 8
Frédéric Saudou, Institut Curie, France
Axonal Transport, Energy Supply and…Huntingtin

Tuesday, March 12 | 8:00AM - 11:15AM
Molecular Motors and Axonal Transport Regulation
Room: Mountain/Lake

Speaker 8 of 8
Glenn F. Rall, Fox Chase Cancer Center, USA
Short Talk: Inter-Neuronal Trafficking of Measles Virus

Tuesday, March 12 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, March 12 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Tuesday, March 12 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, March 12 | 11:30AM - 12:15PM
Round Table Discussions with NIH/NINDS Program Directors
Room: Mountain/Lake

Speaker 1 of 2
Laura Mamounas, NINDS, National Institutes of Health, USA

Tuesday, March 12 | 11:30AM - 12:15PM
Round Table Discussions with NIH/NINDS Program Directors
Room: Mountain/Lake

Speaker 2 of 2
Robert D. Riddle, NINDS, National Institutes of Health, USA

Tuesday, March 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, March 12 | 2:30PM - 4:30PM
Workshop
Room: Mountain/Lake

Speaker 1 of 9
* Jeffery L. Twiss, University of South Carolina, USA

Tuesday, March 12 | 2:30PM - 4:30PM
Workshop
Room: Mountain/Lake

Speaker 2 of 9
Bradley T. Lang, Athersys, USA
Unlocking Spinal Regeneration and Plasticity: Subcutaneous Injections of a Peptide Inhibitor of PTP-sigma Release CSPG Mediated Axonal Entrapment and Promote Robust Behavioral Recovery following Severe Contusive Spinal Cord Injury

Tuesday, March 12 | 2:30PM - 4:30PM
Workshop
Room: Mountain/Lake

Speaker 3 of 9
Richard E. Zigmond, Case Western Reserve University, USA
A New Phenotype for the Well Studied Wallerian Degeneration Slow Mouse

Tuesday, March 12 | 2:30PM - 4:30PM
Workshop
Room: Mountain/Lake

Speaker 4 of 9
Rachel J. Allison, Cambridge Institute for Medical Research, UK
Loss of the Hereditary Spastic Paraplegia Protein Spastin Alters Endosomal Morphology and Trafficking in Non-Polarized Cells and Axons

Tuesday, March 12 | 2:30PM - 4:30PM
Workshop
Room: Mountain/Lake

Speaker 5 of 9
Nicolas Unsain, Montreal Neurological Institute, Canada
XIAP-Dependent Regulation of Caspase Activity in Degenerating Axons

Tuesday, March 12 | 2:30PM - 4:30PM
Workshop
Room: Mountain/Lake

Speaker 6 of 9
Biliana O. Veleva-Rotse, Oregon Health & Science University, USA
Pseudokinases Contribute to Axogenesis in the Developing Cerebral Cortex

Tuesday, March 12 | 2:30PM - 4:30PM
Workshop
Room: Mountain/Lake

Speaker 7 of 9
Bianxiao Cui, Stanford University, USA
The Role of Rab7 in NGF/TrkA Retrograde Signaling

Tuesday, March 12 | 2:30PM - 4:30PM
Workshop
Room: Mountain/Lake

Speaker 8 of 9
Jung Eun Shin, Washington University, USA
Analysis of SCG10 during Axon Degeneration and Regeneration

Tuesday, March 12 | 2:30PM - 4:30PM
Workshop
Room: Mountain/Lake

Speaker 9 of 9
Thomas W. Gould, University of Nevada at Reno, USA
Axon Degeneration Induced by Schwann Cell Ablation is Mediated by Activity-Regulated, Muscle-Derived Thrombin

Tuesday, March 12 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, March 12 | 5:00PM - 7:00PM
Axonal Membrane Dynamics and Organelle Transport
Room: Mountain/Lake

Speaker 1 of 5
* Eran Perlson, Tel Aviv University, Israel

Tuesday, March 12 | 5:00PM - 7:00PM
Axonal Membrane Dynamics and Organelle Transport
Room: Mountain/Lake

Speaker 2 of 5
Britta J. Eickholt, Charité – Universitätsmedizin Berlin, Germany
Spatial and Temporal Control of Neuronal PTEN and Associated Signaling Systems

Tuesday, March 12 | 5:00PM - 7:00PM
Axonal Membrane Dynamics and Organelle Transport
Room: Mountain/Lake

Speaker 3 of 5
Rejji Kuruvilla, Johns Hopkins University, USA
Neurotrophin Trafficking in Neuronal Development

Tuesday, March 12 | 5:00PM - 7:00PM
Axonal Membrane Dynamics and Organelle Transport
Room: Mountain/Lake

Speaker 4 of 5
Thomas L. Schwarz, Children's Hospital Boston and Harvard Medical School, USA
How Mitochondria Move and Why it Matters to a Neuron

Tuesday, March 12 | 5:00PM - 7:00PM
Axonal Membrane Dynamics and Organelle Transport
Room: Mountain/Lake

Speaker 5 of 5
Paul L. McNeil, Georgia Health Sciences University, USA
Short Talk: Promotion of Plasma Membrane Repair by Curcumin: Implications for TBI Therapy

Tuesday, March 12 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, March 12 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay


Tuesday, March 12 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Wednesday, March 13 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, March 13 | 8:00AM - 11:15AM
RNA Targeting and Local Translation
Room: Mountain/Lake

Speaker 1 of 9
* John Houle, Drexel University College of Medicine, USA

Wednesday, March 13 | 8:00AM - 11:15AM
RNA Targeting and Local Translation
Room: Mountain/Lake

Speaker 2 of 9
Jeffery L. Twiss, University of South Carolina, USA
mRNAs Compete for Limited Quantities of Axonal Transport Machinery

Wednesday, March 13 | 8:00AM - 11:15AM
RNA Targeting and Local Translation
Room: Mountain/Lake

Speaker 3 of 9
James Fawcett, University of Cambridge, UK
Why Do CNS Axons Lose the Ability to Regenerate?

Wednesday, March 13 | 8:00AM - 11:15AM
RNA Targeting and Local Translation
Room: Mountain/Lake

Speaker 4 of 9
Chang-Mei Liu, Johns Hopkins University, USA
Short Talk: SIRT1 and MicroRNA-138 Form a Mutual Negative Feedback Loop to Control Axon Regeneration

Wednesday, March 13 | 8:00AM - 11:15AM
RNA Targeting and Local Translation
Room: Mountain/Lake

Speaker 5 of 9
* Dianna E. Willis, Burke-Cornell Medical Research Institute, USA

Wednesday, March 13 | 8:00AM - 11:15AM
RNA Targeting and Local Translation
Room: Mountain/Lake

Speaker 6 of 9
Mustafa Sahin, Boston Children's Hospital, USA
TSC-mTOR Signaling Regulates Axonal mRNA Translation

Wednesday, March 13 | 8:00AM - 11:15AM
RNA Targeting and Local Translation
Room: Mountain/Lake

Speaker 7 of 9
Gianluca Gallo, Temple University, USA
Short Talk: Embryonic Sensory Axons Exhibit Sites of Preferential mRNA Translation

Wednesday, March 13 | 8:00AM - 11:15AM
RNA Targeting and Local Translation
Room: Mountain/Lake

Speaker 8 of 9
Ulrich Hengst, Columbia University, USA
Short Talk: A Novel Role for Intra-Axonal Translation in Alzheimer’s Disease

Wednesday, March 13 | 8:00AM - 11:15AM
RNA Targeting and Local Translation
Room: Mountain/Lake

Speaker 9 of 9
Anne Marion Taylor, University of North Carolina at Chapel Hill, USA
Short Talk: Local Translation of beta-Catenin Regulates Synaptic Vesicle Release Dynamics

Wednesday, March 13 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, March 13 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, March 13 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Wednesday, March 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Wednesday, March 13 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, March 13 | 5:00PM - 7:00PM
Axonal Signaling
Room: Mountain/Lake

Speaker 1 of 5
* Uwe Drescher, King's College London, UK

Wednesday, March 13 | 5:00PM - 7:00PM
Axonal Signaling
Room: Mountain/Lake

Speaker 2 of 5
David D. Ginty, HHMI/Harvard Medical School, USA
The Organization of Neurons that Underlie the Sense of Touch

Wednesday, March 13 | 5:00PM - 7:00PM
Axonal Signaling
Room: Mountain/Lake

Speaker 3 of 5
Gary R. Lewin, Max Delbrück Center for Molecular Medicine, Germany
A Transducosome for the Delivery of Pre-Assembled Mechanotransduction Components for Touch?

Wednesday, March 13 | 5:00PM - 7:00PM
Axonal Signaling
Room: Mountain/Lake

Speaker 4 of 5
Mark H. Tuszynski, University of California, San Diego, USA
Axonal Sprouting and Regeneration in the Central Nervous System

Wednesday, March 13 | 5:00PM - 7:00PM
Axonal Signaling
Room: Mountain/Lake

Speaker 5 of 5
Naoya Yamashita, Johns Hopkins University, USA
Short Talk: A Retrograde Axonal Transport Elicited by Semaphorin3A Drives AMPA Receptor Subunit GluA2 to Dendrites

Wednesday, March 13 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Wednesday, March 13 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay


Wednesday, March 13 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Thursday, March 14 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, March 14 | 8:00AM - 11:15AM
Axonal Maintenance
Room: Mountain/Lake

Speaker 1 of 8
* Andres Couve, Universidad de Chile, Chile

Thursday, March 14 | 8:00AM - 11:15AM
Axonal Maintenance
Room: Mountain/Lake

Speaker 2 of 8
Christine E. Beattie, Ohio State University, USA
The Function of the Survival Motor Neuron (SMN) Protein in Motor Axon Development

Thursday, March 14 | 8:00AM - 11:15AM
Axonal Maintenance
Room: Mountain/Lake

Speaker 3 of 8
Avraham Yaron, Weizmann Institute of Science, Israel
Mechanisms of Axonal Maintenance and Degeneration

Thursday, March 14 | 8:00AM - 11:15AM
Axonal Maintenance
Room: Mountain/Lake

Speaker 4 of 8
Takeshi Fujiwara, Osaka University Graduate School of Medicine, Japan
Short Talk: Axonal Transport Proteins Implicated in the Pathology of Alzheimer’s Disease

Thursday, March 14 | 8:00AM - 11:15AM
Axonal Maintenance
Room: Mountain/Lake

Speaker 5 of 8
* Anthony Paul Barnes, Oregon Health & Science University, USA

Thursday, March 14 | 8:00AM - 11:15AM
Axonal Maintenance
Room: Mountain/Lake

Speaker 6 of 8
Joseph W. Lewcock, Denali Therapeutics, USA
Intracellular Pathways that Underlie Axon Degeneration in Development and Disease

Thursday, March 14 | 8:00AM - 11:15AM
Axonal Maintenance
Room: Mountain/Lake

Speaker 7 of 8
Guo-li Ming, University of Pennsylvania, USA
Epigenetic Regulation of Axonal Growth

Thursday, March 14 | 8:00AM - 11:15AM
Axonal Maintenance
Room: Mountain/Lake

Speaker 8 of 8
Patrick Lüningschrör, University of Wuerzburg, Germany
Short Talk: Functional Characterization of Plekhgh5 in the Nervous System

Thursday, March 14 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Thursday, March 14 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, March 14 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Thursday, March 14 | 5:00PM - 6:15PM
Axon-Glia Interactions
Room: Mountain/Lake

Speaker 1 of 4
* Michael Fainzilber, Weizmann Institute of Science, Israel

Thursday, March 14 | 5:00PM - 6:15PM
Axon-Glia Interactions
Room: Mountain/Lake

Speaker 2 of 4
Klaus-Armin Nave, Max Planck Institute of Experimental Medicine, Germany
Glial Support of Axon Function and Survival

Thursday, March 14 | 5:00PM - 6:15PM
Axon-Glia Interactions
Room: Mountain/Lake

Speaker 3 of 4
Bruce D. Carter, Vanderbilt University School of Medicine, USA
Mechanisms Regulating Schwann Cell Differentiation and their Pathological Dysregulation

Thursday, March 14 | 5:00PM - 6:15PM
Axon-Glia Interactions
Room: Mountain/Lake

Speaker 4 of 4
Kelly Monk, Oregon Health & Science University, USA
Short Talk: Adhesion-G Protein-Coupled Receptor Signaling in Myelination

Thursday, March 14 | 6:15PM - 7:15PM
Closing Keynote Address
Room: Mountain/Lake

Speaker 1 of 1
Martin E. Schwab, University of Zürich, Switzerland
Axon Growth and Regeneration: From Basics to Clinic

Thursday, March 14 | 7:15PM - 8:15PM
Dinner
Room: Granhall


Thursday, March 14 | 7:15PM - 8:15PM
Social Hour
Room: Granhall


Thursday, March 14 | 8:00PM - 11:00PM
Entertainment
Room: Granhall


Thursday, March 14 | 8:15PM - 11:00PM
Cash Bar
Room: Granhall


Friday, March 15 | 10:25AM - 10:25AM
Departure


*Session Chair.