Web Desc
RNA Silencing
Organizer(s): David C. Baulcombe and Irene Bozzoni
Date: March 19 - 24, 2013
Location: Whistler Conference Centre, Whistler, BC, Canada
Sponsored by Cell Research
Summary of Meeting:
RNA silencing systems are now well established as key components of regulation and control in many eukaryotes including animals and plants. The first flush of discoveries was focused around post-transcriptional regulation. It was anticipated that the small RNA specificity determinants of these silencing systems could be negative switches acting alongside transcription factors control of gene expression during growth, development and responses to external stimuli. More recently, the emphasis has shifted. In terms of post-transcriptional regulation, it is now recognized that there are only a few examples in plants and worms in which sRNAs are simple switches. These RNAs are now seen as modulators or fine tuners of post-transcriptional regulation that are often components of negative feedback loops or of control networks in which there are long RNA negative regulators of the sRNAs and secondary sRNAs. The sRNAs can be transported or secreted out of cells and so the RNA mediated control networks may extend beyond one cell. The anticipated potential of sRNA therapeutics has yet to be delivered but they are proving to be a powerful diagnostic tool in cancer and other diseases. A second emerging area is in the link between sRNAs and epigenetic regulation. This link was revealed first from plant work but it is now known in animals in connection with piwi-associated RNAs or piRNAs. These epigenetic sRNAs and piRNAs are certainly important in defense against transposable elements, but it is possible that they also influence genetic or epigenetic regulation in other cell types. In this complex array of sRNA functions, growing interest is now devoted also to the crucial role of long noncoding RNAs in processes of gene expression control both at the transcriptional and post-transcriptional levels. This Keystone Symposia meeting on RNA Silencing will focus on these emerging topics of network control systems and epigenetic regulation by various types of sRNA. The focus on RNA silencing in general provides an umbrella under which speakers from different areas of research (e.g., transcriptional regulation, cancer biology, development, epigenetics and virology) are being brought together in an environment that is highly conducive to cross-talk. Emphasis has also be placed on showcasing early stage investigators presenting on the program with a view to promoting the next generation of scientists in the RNA silencing field.
Scholarship Deadline: November 15 2012
Discounted Abstract Deadline: November 15 2012
Abstract Deadline: December 20 2012
Discounted Registration Deadline: January 18 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Cell Research
We gratefully acknowledge additional support for this conference from:
Exiqon A/SIntegrated DNA Technologies
We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1R13HD075439-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Foyer


Wednesday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Wednesday, March 20 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky B

Speaker 1 of 2
* David C. Baulcombe, University of Cambridge, UK

Wednesday, March 20 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Sea to Sky B

Speaker 2 of 2
Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
New Small RNA Pathway Genes from Functional Genomics and Phylogenetic Profiling

Wednesday, March 20 | 9:00AM - 12:15PM
Posttranscriptional RNA Silencing Pathways in Diverse Organi
sms

Room: Sea to Sky B

Speaker 1 of 7
* Irene Bozzoni, University La Sapienza, Rome, Italy

Wednesday, March 20 | 9:00AM - 12:15PM
Posttranscriptional RNA Silencing Pathways in Diverse Organi
sms

Room: Sea to Sky B

Speaker 2 of 7
Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
The Interactions of GW182 Proteins with PABP and Deadenylases are Required for Both Translational Repression and Degradation of miRNA Targets

Wednesday, March 20 | 9:00AM - 12:15PM
Posttranscriptional RNA Silencing Pathways in Diverse Organi
sms

Room: Sea to Sky B

Speaker 3 of 7
Annick Harel-Bellan, Commissariat à l'Energie Atomique (CEA), Saclay, France
Argonaute Proteins Couple Chromatin Silencing to Alternative Splicing

Wednesday, March 20 | 9:00AM - 12:15PM
Posttranscriptional RNA Silencing Pathways in Diverse Organi
sms

Room: Sea to Sky B

Speaker 4 of 7
Craig P. Hunter, Harvard University, USA
Mobile Silencing RNA in C. elegans

Wednesday, March 20 | 9:00AM - 12:15PM
Posttranscriptional RNA Silencing Pathways in Diverse Organi
sms

Room: Sea to Sky B

Speaker 5 of 7
Olivier Voinnet, Swiss Federal Institute of Technology, Zürich, Switzerland
Antiviral RNA Interference in Mammalian Cells

Wednesday, March 20 | 9:00AM - 12:15PM
Posttranscriptional RNA Silencing Pathways in Diverse Organi
sms

Room: Sea to Sky B

Speaker 6 of 7
Jennifer A. Broderick, University of Massachusetts Medical School, USA
Short Talk: Silencing Gene Expression by Recruiting RISC

Wednesday, March 20 | 9:00AM - 12:15PM
Posttranscriptional RNA Silencing Pathways in Diverse Organi
sms

Room: Sea to Sky B

Speaker 7 of 7
Alla Grishok, Columbia University Medical Center, USA
Short Talk: Positive Regulation of Gene Expression by CSR-1 RNAi Pathway in C. elegans

Wednesday, March 20 | 9:40AM - 10:00AM
Coffee Break
Room: Grand Foyer


Wednesday, March 20 | 12:15PM - 4:30PM
On Own for Lunch and Recreation


Wednesday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Wednesday, March 20 | 5:00PM - 7:00PM
piRNAs and RNA-Mediated Epigenetic Modification I
Room: Sea to Sky B

Speaker 1 of 5
* Eric A. Miska, University of Cambridge, UK

Wednesday, March 20 | 5:00PM - 7:00PM
piRNAs and RNA-Mediated Epigenetic Modification I
Room: Sea to Sky B

Speaker 2 of 5
Phillip D. Zamore, University of Massachusetts Medical School, USA
What Fruit Flies Teach Us About RNA Silencing

Wednesday, March 20 | 5:00PM - 7:00PM
piRNAs and RNA-Mediated Epigenetic Modification I
Room: Sea to Sky B

Speaker 3 of 5
Haifan Lin, Yale University, USA
A Major Epigenetic Programming Mechanism Guided by piRNAs

Wednesday, March 20 | 5:00PM - 7:00PM
piRNAs and RNA-Mediated Epigenetic Modification I
Room: Sea to Sky B

Speaker 4 of 5
René F. Ketting, Institute for Molecular Biology, Germany
piRNA and mRNA Inheritance in Zebrafish

Wednesday, March 20 | 5:00PM - 7:00PM
piRNAs and RNA-Mediated Epigenetic Modification I
Room: Sea to Sky B

Speaker 5 of 5
Alex Bortvin, Carnegie Institution of Washington, USA
Short Talk: Mouse MAELSTROM Associates with piRNA Precursors

Wednesday, March 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Thursday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Thursday, March 21 | 8:00AM - 11:00AM
piRNAs and RNA-Mediated Epigenetic Modification II
Room: Sea to Sky B

Speaker 1 of 6
* Phillip D. Zamore, University of Massachusetts Medical School, USA

Thursday, March 21 | 8:00AM - 11:00AM
piRNAs and RNA-Mediated Epigenetic Modification II
Room: Sea to Sky B

Speaker 2 of 6
Eric A. Miska, University of Cambridge, UK
Small RNAs: From Genome Maintenance to Innate Immunity

Thursday, March 21 | 8:00AM - 11:00AM
piRNAs and RNA-Mediated Epigenetic Modification II
Room: Sea to Sky B

Speaker 3 of 6
David C. Baulcombe, University of Cambridge, UK
Engineering Epigenetically Modified Plants

Thursday, March 21 | 8:00AM - 11:00AM
piRNAs and RNA-Mediated Epigenetic Modification II
Room: Sea to Sky B

Speaker 4 of 6
Hiten D. Madhani, University of California, San Francisco, USA
Short Talk: Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense

Thursday, March 21 | 8:00AM - 11:00AM
piRNAs and RNA-Mediated Epigenetic Modification II
Room: Sea to Sky B

Speaker 5 of 6
Nicholas J. Proudfoot, University of Oxford, UK
Nuclear RNA Interference Acts on Mammalian Genes

Thursday, March 21 | 8:00AM - 11:00AM
piRNAs and RNA-Mediated Epigenetic Modification II
Room: Sea to Sky B

Speaker 6 of 6
Steven E. Jacobsen, University of California, Los Angeles, USA
RNA Directed DNA Methylation

Thursday, March 21 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Thursday, March 21 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Thursday, March 21 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Thursday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Thursday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Thursday, March 21 | 5:00PM - 7:00PM
Long ncRNA
Room: Sea to Sky B

Speaker 1 of 5
* Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

Thursday, March 21 | 5:00PM - 7:00PM
Long ncRNA
Room: Sea to Sky B

Speaker 2 of 5
John L. Rinn, University of Colorado Boulder, USA
Linking RNA to Human Health and Disease

Thursday, March 21 | 5:00PM - 7:00PM
Long ncRNA
Room: Sea to Sky B

Speaker 3 of 5
Gordon G. Simpson, University of Dundee, UK
Aberrant Read-Through Transcription and Chimeric RNA Formation Is Controlled
by Arabidopsis thaliana FPA and DICER-LIKE 1


Thursday, March 21 | 5:00PM - 7:00PM
Long ncRNA
Room: Sea to Sky B

Speaker 4 of 5
Sundeep Kalantry, University of Michigan Medical School, USA
Short Talk: Dynamic Requirement of the Tsix Long Noncoding RNA in Regulating Mouse Imprinted and Random X-Inactivation

Thursday, March 21 | 5:00PM - 7:00PM
Long ncRNA
Room: Sea to Sky B

Speaker 5 of 5
Ursula E. Schoeberl, Institute of Molecular Biotechnology of the Austrian Academy of Science, Austria
Short Talk: Regulation of Noncoding RNA Transcription Involved in DNA Elimination in Tetrahymena

Thursday, March 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Thursday, March 21 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Friday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Friday, March 22 | 8:00AM - 11:15AM
ncRNA in Development and Disease I
Room: Sea to Sky B

Speaker 1 of 7
* John L. Rinn, University of Colorado Boulder, USA

Friday, March 22 | 8:00AM - 11:15AM
ncRNA in Development and Disease I
Room: Sea to Sky B

Speaker 2 of 7
Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Defining the ceRNA Rules: From Mathematical Modeling to in vivo Validation

Friday, March 22 | 8:00AM - 11:15AM
ncRNA in Development and Disease I
Room: Sea to Sky B

Speaker 3 of 7
Irene Bozzoni, University La Sapienza, Rome, Italy
Role of Noncoding RNAs in Muscle Differentiation and in Neuromuscular Disorders

Friday, March 22 | 8:00AM - 11:15AM
ncRNA in Development and Disease I
Room: Sea to Sky B

Speaker 4 of 7
Xavier Estivill, Sidra Medical and Research Center, Qatar
Different Roles of Noncoding RNAs in Neurodegenerative Diseases

Friday, March 22 | 8:00AM - 11:15AM
ncRNA in Development and Disease I
Room: Sea to Sky B

Speaker 5 of 7
Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
circRNAs

Friday, March 22 | 8:00AM - 11:15AM
ncRNA in Development and Disease I
Room: Sea to Sky B

Speaker 6 of 7
Pavel Sumazin, Columbia University, USA
Short Talk: ceRNA Regulatory Interactions Cooperate with Genomic Variability to Modulate Drivers of Tumorigenesis

Friday, March 22 | 8:00AM - 11:15AM
ncRNA in Development and Disease I
Room: Sea to Sky B

Speaker 7 of 7
Hervé Seitz, CNRS, France
Short Talk: Every Predicted miRNA Target Is Not Functionally Targeted: Revisiting the Nature of miRNA/mRNA Interaction

Friday, March 22 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Friday, March 22 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Friday, March 22 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Friday, March 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Friday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Friday, March 22 | 5:00PM - 7:00PM
ncRNA in Development and Disease II
Room: Sea to Sky B

Speaker 1 of 6
* Valerio Orlando, King Abdullah University of Science and Technology, Saudi Arabia

Friday, March 22 | 5:00PM - 7:00PM
ncRNA in Development and Disease II
Room: Sea to Sky B

Speaker 2 of 6
Yijun Qi, Tsinghua University, China
DiRNAs: Discovery and Mechanism

Friday, March 22 | 5:00PM - 7:00PM
ncRNA in Development and Disease II
Room: Sea to Sky B

Speaker 3 of 6
Erik Larsson, University of Gothenburg, Sweden
Short Talk: A Long Noncoding RNA Specifically Activated by Somatic DNA Amplification in Cancer

Friday, March 22 | 5:00PM - 7:00PM
ncRNA in Development and Disease II
Room: Sea to Sky B

Speaker 4 of 6
Charles E. Rogler, Albert Einstein College of Medicine, USA
Short Talk: Two Small RNAs Derived from ncRNA, RMRP, Have Gene Regulatory Activity Relevant to Human Cartilage Hair Hypoplasia (CHH) Syndromes

Friday, March 22 | 5:00PM - 7:00PM
ncRNA in Development and Disease II
Room: Sea to Sky B

Speaker 5 of 6
Gracjan P. Michlewski, University of Edinburgh, UK
Short Talk: Tissue-Specific Control of MiRNA Biogenesis

Friday, March 22 | 5:00PM - 7:00PM
ncRNA in Development and Disease II
Room: Sea to Sky B

Speaker 6 of 6
Heidi Schwarzenbach, University Medical Center Hamburg-Eppendorf, Germany
Circulating microRNAs as Biomarkers in Cancer Patients

Friday, March 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Friday, March 22 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Saturday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Saturday, March 23 | 8:00AM - 11:15AM
ncRNA in Development and Disease III
Room: Sea to Sky B

Speaker 1 of 7
* Xavier Estivill, Sidra Medical and Research Center, Qatar

Saturday, March 23 | 8:00AM - 11:15AM
ncRNA in Development and Disease III
Room: Sea to Sky B

Speaker 2 of 7
Valerio Orlando, King Abdullah University of Science and Technology, Saudi Arabia
A Genome-Wide Role for Nuclear Dicer1 and Ago1 in Transcriptional Regulation in Human Cells

Saturday, March 23 | 8:00AM - 11:15AM
ncRNA in Development and Disease III
Room: Sea to Sky B

Speaker 3 of 7
Lin He, University of California, Berkeley, USA
A Polycistronic miRNA Oncogene mir17-92 Confers Balance between Proliferation and Apoptosis

Saturday, March 23 | 8:00AM - 11:15AM
ncRNA in Development and Disease III
Room: Sea to Sky B

Speaker 4 of 7
Jørgen Kjems, Aarhus University, Denmark
Circular miRNA Sponges - Implications in Human Diseases

Saturday, March 23 | 8:00AM - 11:15AM
ncRNA in Development and Disease III
Room: Sea to Sky B

Speaker 5 of 7
Reuven Agami, Netherlands Cancer Institute, Netherlands
Alternative Cleavage and Polyadenylation of mRNAs in Genetic Diseases

Saturday, March 23 | 8:00AM - 11:15AM
ncRNA in Development and Disease III
Room: Sea to Sky B

Speaker 6 of 7
Keith T. Gagnon, Southern Illinois University, USA
Short Talk: Argonaute and RNAi in the Mammalian Cell Nucleus

Saturday, March 23 | 8:00AM - 11:15AM
ncRNA in Development and Disease III
Room: Sea to Sky B

Speaker 7 of 7
Gabrielle Haas, Institut de Biologie Moléculaire et Cellulaire (IBMC), France
Short Talk: Molecular Features Involved in miRNA Destabilization by Mouse Cytomegalovirus

Saturday, March 23 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Saturday, March 23 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Saturday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Saturday, March 23 | 5:00PM - 7:00PM
RNA Silencing in Virus Disease
Room: Sea to Sky B

Speaker 1 of 5
* David C. Baulcombe, University of Cambridge, UK

Saturday, March 23 | 5:00PM - 7:00PM
RNA Silencing in Virus Disease
Room: Sea to Sky B

Speaker 2 of 5
Shou-Wei Ding, University of California, Riverside, USA
Induction and Suppression of RNA Silencing during Mammalian Virus Infection

Saturday, March 23 | 5:00PM - 7:00PM
RNA Silencing in Virus Disease
Room: Sea to Sky B

Speaker 3 of 5
Eva H. Gottwein, Northwestern University, USA
Viral Mimics of Cellular microRNAs

Saturday, March 23 | 5:00PM - 7:00PM
RNA Silencing in Virus Disease
Room: Sea to Sky B

Speaker 4 of 5
John C. Burnett, Beckman Research Institute at the City of Hope, USA
Small Noncoding RNA Therapies for HIV-1

Saturday, March 23 | 5:00PM - 7:00PM
RNA Silencing in Virus Disease
Room: Sea to Sky B

Speaker 5 of 5
Juan Alberto Mondotte, Institut Pasteur, France
Short Talk: The RNAi Pathway Is a Key Factor Controlling Virus-Host Specificity in Drosophila melanogaster

Saturday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Saturday, March 23 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A


Saturday, March 23 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Sunday, March 24 | 10:25AM - 10:25AM
Departure


*Session Chair.