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Web Desc
Molecular Clockworks and the Regulation of Cardio-Metabolic Function
Organizer(s): Garret A. FitzGerald and Joseph S. Takahashi
Date: April 03 - 07, 2013
Location: Snowbird Resort, Snowbird, UT, USA
Supported by the Directors' Fund
Summary of Meeting:
Several discoveries point to the importance of the molecular clockworks as an integrative system in biology. The molecular clock is highly conserved and remarkably robust in resisting disruption; it is highly regulated and is placed centrally amongst biological networks that communicate between tissues. In recent years it has become apparent that peripheral clocks, widely distributed, retain the capacity for independence as well as operating under the direction of the master clock in the supracharismatic nucleus (SCN). Indeed, evidence has begun to emerge that peripheral clocks talk to each other and back to the SCN. As we begin to understand the impact of major environmental influences, such as food restriction and fluctuations in body temperature, on clock integration and behavior, so we will begin to elucidate the roles of fine adjusters, such as hormones, physical forces and nutritional ingredients, all of which can impact asymmetrically individual peripheral clocks and potentially signal between them. Much remains to be learned about the multiple levels of regulation of clockworks at the transcriptional, translational, post translational and epigenomic levels, information that lends itself to systems wide analysis. Indeed, increasing insight into the systems biology of the molecular clock promises to rationalize selection of drug targets whereby we might modulate clock function. High throughput screens have already yielded novel approaches to regulating the phase and amplitude of molecular clocks. Evocation of clock dependent phenotypes in humans has come of age with recognition that the oscillatory nature of the metabolome and the ability to track gene oscillations in several tissues ex vivo will complement increasingly sophisticated approaches to segregating endogenous rhythms from tracking time dependent changes in tissue function in humans. Experiments in a range of model systems have pointed to the importance of the molecular clock in carbohydrate and lipid metabolism, cardiovascular function and aging. This program will assemble investigators who work in multiple model systems, including humans to share information on the multiple ways in which the molecular clock is regulated, how its systems are integrated and how that knowledge might be harvested to enhance our understanding of human physiology and to yield novel treatments for human disease.
Scholarship Deadline: December 3 2012
Discounted Abstract Deadline: December 3 2012
Abstract Deadline: January 3 2013
Discounted Registration Deadline: January 28 2013
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-04
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Wednesday, April 03 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Thursday, April 04 | 12:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby


Thursday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff


Thursday, April 04 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Ballroom 3

Speaker 1 of 3
* Garret A. FitzGerald, University of Pennsylvania, USA

Thursday, April 04 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Ballroom 3

Speaker 2 of 3
* Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical Center, USA

Thursday, April 04 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Ballroom 3

Speaker 3 of 3
Eric Schadt, Mount Sinai School of Medicine, USA
Systems Integration by the Molecular Clock

Thursday, April 04 | 9:00AM - 11:00AM
Clockworks I
Room: Ballroom 3

Speaker 1 of 4
* Garret A. FitzGerald, University of Pennsylvania, USA

Thursday, April 04 | 9:00AM - 11:00AM
Clockworks I
Room: Ballroom 3

Speaker 2 of 4
Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical Center, USA
Transcriptional Architecture and Chromatin Dynamics of the Circadian Clock

Thursday, April 04 | 9:00AM - 11:00AM
Clockworks I
Room: Ballroom 3

Speaker 3 of 4
John Hogenesch, University of Pennsylvania School of Medicine, USA
A Transcriptional Map of Mouse Circadian Time and Space

Thursday, April 04 | 9:00AM - 11:00AM
Clockworks I
Room: Ballroom 3

Speaker 4 of 4
Jerome Menet, Brandeis University, USA
Mechanistic Insights from Genome-Wide Circadian Regulation of Chromatin

Thursday, April 04 | 9:40AM - 10:00AM
Coffee Break
Room: Ballroom Lobby


Thursday, April 04 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, April 04 | 11:00AM - 12:00PM
Workshop: Program Tips from NIDDK
Room: Ballroom 3

Speaker 1 of 1
* Corinne M. Silva, NIDDK, National Institutes of Health, USA

Thursday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby


Thursday, April 04 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, April 04 | 5:00PM - 7:00PM
Clockworks II
Room: Ballroom 3

Speaker 1 of 5
* Carla B. Green, University of Texas Southwestern Medical Center, USA

Thursday, April 04 | 5:00PM - 7:00PM
Clockworks II
Room: Ballroom 3

Speaker 2 of 5
Ueli Schibler, University of Geneva, Switzerland
Signaling to Peripheral Clocks

Thursday, April 04 | 5:00PM - 7:00PM
Clockworks II
Room: Ballroom 3

Speaker 3 of 5
Thomas P. Burris, Washington University School of Medicine, USA
Chemical Biology of the Clock

Thursday, April 04 | 5:00PM - 7:00PM
Clockworks II
Room: Ballroom 3

Speaker 4 of 5
Martha Merrow, Ludwig-Maximilians-Universität München, Germany
Rhythms from Molecules to Behavior in C. elegans

Thursday, April 04 | 5:00PM - 7:00PM
Clockworks II
Room: Ballroom 3

Speaker 5 of 5
Immanuel Lerner, Hebrew University, Israel
Short Talk: Clk mRNA Turnover de-Noises Circadian Transcription and Behavior in Time and Space

Thursday, April 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby


Thursday, April 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby


Friday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff


Friday, April 05 | 8:00AM - 11:00AM
Cardio-Metabolic I
Room: Ballroom 3

Speaker 1 of 6
* Ueli Schibler, University of Geneva, Switzerland

Friday, April 05 | 8:00AM - 11:00AM
Cardio-Metabolic I
Room: Ballroom 3

Speaker 2 of 6
Mukesh K. Jain, Case Western Reserve University, USA
KLF15 Links Circadian Rhythms to Cardiometabolic Function

Friday, April 05 | 8:00AM - 11:00AM
Cardio-Metabolic I
Room: Ballroom 3

Speaker 3 of 6
Hitoshi Okamura, Kyoto University, Japan
Clock Gene, Aldosterone and Hypertension

Friday, April 05 | 8:00AM - 11:00AM
Cardio-Metabolic I
Room: Ballroom 3

Speaker 4 of 6
David Rotter, University of Texas Southwestern Medical Center, USA
Short Talk: Regulator of Calcineurin 1 (Rcan1) Confers Time-of-Day Protection to the Heart from Ischemia/Reperfusion Damage

Friday, April 05 | 8:00AM - 11:00AM
Cardio-Metabolic I
Room: Ballroom 3

Speaker 5 of 6
Felix Naef, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Mechanisms of Phase-Specific Circadian Transcription in Mouse Liver

Friday, April 05 | 8:00AM - 11:00AM
Cardio-Metabolic I
Room: Ballroom 3

Speaker 6 of 6
Carla B. Green, University of Texas Southwestern Medical Center, USA
Circadian Post-Transcriptional Regulation of Metabolic Pathways

Friday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Friday, April 05 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Friday, April 05 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby


Friday, April 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby


Friday, April 05 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Friday, April 05 | 5:00PM - 7:00PM
Clockworks III
Room: Ballroom 3

Speaker 1 of 5
* Martha Merrow, Ludwig-Maximilians-Universität München, Germany

Friday, April 05 | 5:00PM - 7:00PM
Clockworks III
Room: Ballroom 3

Speaker 2 of 5
Susan S. Golden, University of California, San Diego, USA
Regulation of and by the Circadian Oscillator in the Cyanobacterial Cell

Friday, April 05 | 5:00PM - 7:00PM
Clockworks III
Room: Ballroom 3

Speaker 3 of 5
Akhilesh B. Reddy, University of Cambridge, UK
EMBO Young Investigator Lecture: Redox Oscillations and the Clockwork

Friday, April 05 | 5:00PM - 7:00PM
Clockworks III
Room: Ballroom 3

Speaker 4 of 5
Hiroki R. Ueda, Center for Developmental Biology, Japan
Light-Response Program in the Mammalian Circadian Clocks

Friday, April 05 | 5:00PM - 7:00PM
Clockworks III
Room: Ballroom 3

Speaker 5 of 5
Pagkapol Y. Pongsawakul, University of California, San Diego, USA
Short Talk: The Role of Cytoplasmic CRYPTOCHROME in Regulating the cAMP Signaling Pathway

Friday, April 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby


Friday, April 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby


Saturday, April 06 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff


Saturday, April 06 | 8:00AM - 11:00AM
Cardio-Metabolic II
Room: Ballroom 3

Speaker 1 of 6
* John Hogenesch, University of Pennsylvania School of Medicine, USA

Saturday, April 06 | 8:00AM - 11:00AM
Cardio-Metabolic II
Room: Ballroom 3

Speaker 2 of 6
R. Daniel Rudic, Georgia Regents University, USA
The Vascular Biology of the Circadian Clock

Saturday, April 06 | 8:00AM - 11:00AM
Cardio-Metabolic II
Room: Ballroom 3

Speaker 3 of 6
Satchidananda Panda, The Salk Institute for Biological Studies, USA
Time-Restricted Feeding Protects Against Nutrition Challenges

Saturday, April 06 | 8:00AM - 11:00AM
Cardio-Metabolic II
Room: Ballroom 3

Speaker 4 of 6
Martin E. Young, University of Alabama at Birmingham, USA
Clock Control of Cardiac Metabolism and Function

Saturday, April 06 | 8:00AM - 11:00AM
Cardio-Metabolic II
Room: Ballroom 3

Speaker 5 of 6
Frank A.J.L. Scheer, Harvard Medical School, USA
Endogenous Biological Rhythms of Cardiovascular and Metabolic Function in Humans

Saturday, April 06 | 8:00AM - 11:00AM
Cardio-Metabolic II
Room: Ballroom 3

Speaker 6 of 6
Hélène Duez, INSERM Institut Pasteur Lille, University of Lille, France
Short Talk: The Clock Component Rev-erbalpha Modulates Skeletal Muscle Oxidative Capacity by Regulating Mitochondrial Biogenesis and Autophagy

Saturday, April 06 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Saturday, April 06 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Saturday, April 06 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Saturday, April 06 | 5:00PM - 7:00PM
Cardio-Metabolic III
Room: Ballroom 3

Speaker 1 of 5
* Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical Center, USA

Saturday, April 06 | 5:00PM - 7:00PM
Cardio-Metabolic III
Room: Ballroom 3

Speaker 2 of 5
Joseph T. Bass, Northwestern University, USA
Metabolic Consequences and Bioenergetic Basis of Clock Dysfunction

Saturday, April 06 | 5:00PM - 7:00PM
Cardio-Metabolic III
Room: Ballroom 3

Speaker 3 of 5
Amita Sehgal, University of Pennsylvania Perelman School of Medicine, USA
Role of Steriod Signaling and a Nuclear Receptor in the Drosophila Clock

Saturday, April 06 | 5:00PM - 7:00PM
Cardio-Metabolic III
Room: Ballroom 3

Speaker 4 of 5
Annie Lee Hsieh, University of Pennsylvania, USA
Short Talk: Oncogenic c- and N-Myc Disrupt Circadian Rhythm

Saturday, April 06 | 5:00PM - 7:00PM
Cardio-Metabolic III
Room: Ballroom 3

Speaker 5 of 5
Garret A. FitzGerald, University of Pennsylvania, USA
Peripheral Clocks in Cardiometabolic and Central Function; Integration of the Inflammatory Response

Saturday, April 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 2


Saturday, April 06 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2


Saturday, April 06 | 9:00PM - 11:00PM
Cash Bar
Room: Ballroom 2


Sunday, April 07 | 10:25AM - 10:25AM
Departure


*Session Chair.