Web Desc
Immune Activation in HIV Infection: Basic Mechanisms and Clinical Implications
Organizer(s): Irini Sereti, Michaela Müller-Trutwin, Damian F.J. Purcell and Mauro Schechter
Date: April 03 - 08, 2013
Location: Beaver Run Resort, Breckenridge, CO, USA
Sponsored by Sangamo BioSciences, Inc. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
For important information on the coronavirus, please click here
Summary of Meeting:
One major hallmark of HIV infection is chronic immune activation that promotes viral replication and drives CD4+ T cell depletion. The mechanisms leading to Immune activation are not well understood, and strategies to dampen it are urgently needed. Immune activation in HIV infection can stem from foreign antigen stimulation, including HIV, microbial products and co-infections as well as compensatory homeostatic mechanisms. Continuous immune stimulation most likely creates a permissive environment for further viral replication, while temporarily allowing successful replenishment of the T-cell pool. Type I interferon, microbial translocation, activated (but ineffective) effector T cells, dysfunctional regulatory T cells and inadequate T helper 17 cells have all been suggested to play important roles in the cycle of activation, functional exhaustion and T-cell death that leads to immunodeficiency. In treated HIV infection, chronic immune activation persists and is implicated in non-infectious clinical complications of HIV that account for most of the morbidity and mortality in patients treated with anti-retroviral therapy. The goal of the meeting will be to update the participants on the new insights of mechanisms of immune activation and its deleterious effects on HIV infection from transmission to chronic treated infection, and how this knowledge could potentially translate to treatment interventions. Our vision is to bring together basic science (even beyond HIV), immunology, virology and clinical science into each session with the hope that participants will interact and be inspired for collaborative translational projects.
Global Health Travel Award Deadline: November 6 2012
Scholarship Deadline: December 3 2012
Discounted Abstract Deadline: December 3 2012
Abstract Deadline: January 3 2013
Discounted Registration Deadline: January 29 2013
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates FoundationSangamo BioSciences, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Bristol-Myers Squibb Company
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI104337-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Wednesday, April 03 | 3:00PM - 7:30PM
Arrival and Registration
Room: Foyer


Wednesday, April 03 | 6:15PM - 7:15PM
Refreshments
Room: Foyer


Wednesday, April 03 | 7:15PM - 9:00PM
Welcome and Keynote Session
Room: Colorado Ballroom

Speaker 1 of 4
* Michaela Müller-Trutwin, Institut Pasteur, France

Wednesday, April 03 | 7:15PM - 9:00PM
Welcome and Keynote Session
Room: Colorado Ballroom

Speaker 2 of 4
* Irini Sereti, NIAID, National Institutes of Health, USA
Welcome Remarks

Wednesday, April 03 | 7:15PM - 9:00PM
Welcome and Keynote Session
Room: Colorado Ballroom

Speaker 3 of 4
Mary Carrington, NCI, National Institutes of Health, USA
Effects of HLA-Class 1 Diversity on HIV control and the Art of Multitasking

Wednesday, April 03 | 7:15PM - 9:00PM
Welcome and Keynote Session
Room: Colorado Ballroom

Speaker 4 of 4
Michael M. Lederman, Case Western Reserve University, USA
Residual Immune Dysregulation Syndrome (RIDS) in Treated HIV Infection

Thursday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Thursday, April 04 | 8:00AM - 11:15AM
Molecular and Cellular Biology of Immune Activation
Room: Colorado Ballroom

Speaker 1 of 8
* Guido Silvestri, Emory University School of Medicine, USA

Thursday, April 04 | 8:00AM - 11:15AM
Molecular and Cellular Biology of Immune Activation
Room: Colorado Ballroom

Speaker 2 of 8
* Marcus Altfeld, Heinrich-Pette-Institute, Germany

Thursday, April 04 | 8:00AM - 11:15AM
Molecular and Cellular Biology of Immune Activation
Room: Colorado Ballroom

Speaker 3 of 8
Charles R. Mackay, Monash University, Australia
Diet and Metabolite Sensing GPCRs Regulate Gut Homeostasis and Immune Responses

Thursday, April 04 | 8:00AM - 11:15AM
Molecular and Cellular Biology of Immune Activation
Room: Colorado Ballroom

Speaker 4 of 8
Susan Moir, NIAID, National Institutes of Health, USA
Immunopathogenesis of B Cells in HIV Infection

Thursday, April 04 | 8:00AM - 11:15AM
Molecular and Cellular Biology of Immune Activation
Room: Colorado Ballroom

Speaker 5 of 8
George Kassiotis, Francis Crick Institute, UK
Potential Mechanisms of Immune Activation in Immunodeficient Mice

Thursday, April 04 | 8:00AM - 11:15AM
Molecular and Cellular Biology of Immune Activation
Room: Colorado Ballroom

Speaker 6 of 8
Frank Kirchhoff, University of Ulm, Germany
Possible Role of Viral Properties in HIV-Induced Immune Activation

Thursday, April 04 | 8:00AM - 11:15AM
Molecular and Cellular Biology of Immune Activation
Room: Colorado Ballroom

Speaker 7 of 8
Gilad Doitsh, J. David Gladstone Institutes, USA
Short Talk: HIV Triggers Pyroptosis, an Intense Inflammatory Form of Programmed Cell Death, Promoting CD4 T Cell Depletion in Lymphoid Tissues

Thursday, April 04 | 8:00AM - 11:15AM
Molecular and Cellular Biology of Immune Activation
Room: Colorado Ballroom

Speaker 8 of 8
Clovis Steve Palmer, Burnet Institute, Australia
Short Talk: Glucose Metabolism Is an Integral Process in CD4+ T Cell Activation and Inflammation in HIV-1 Infected Subjects

Thursday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, April 04 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, April 04 | 11:15AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Thursday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Thursday, April 04 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Targets of IA
Room: Colorado Ballroom

Speaker 1 of 10
* Peter W. Hunt, University of California, San Francisco, USA

Thursday, April 04 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Targets of IA
Room: Colorado Ballroom

Speaker 2 of 10
* Sharon R. Lewin, University of Melbourne, Australia

Thursday, April 04 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Targets of IA
Room: Colorado Ballroom

Speaker 3 of 10
Marcus Altfeld, Heinrich-Pette-Institute, Germany
In vivo Treatment with a TLR7/9 Antagonist Reduces HIV-1-Associated Immune Activation in a Humanized Mouse Model of HIV-1 Infection

Thursday, April 04 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Targets of IA
Room: Colorado Ballroom

Speaker 4 of 10
Mingjian Fei, Genentech, USA
The NAD+-Dependent Deacetylase SIRT1 as a New Regulator of T Cell Senescence in HIV Infection

Thursday, April 04 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Targets of IA
Room: Colorado Ballroom

Speaker 5 of 10
Joseph Hiatt, NIAID, National Institutes of Health, USA
Dynamic Interactions between CD4 and alpha4beta7 on Primary CD4+ T Cells Indicates a Novel Coupling of these Two Costimulatory Receptors

Thursday, April 04 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Targets of IA
Room: Colorado Ballroom

Speaker 6 of 10
Rui Andre Raposo, George Washington University, USA
Host Correlates Distinguish Low-Risk and High-Risk HIV-1 Disease Progression in HLA-B*5701 Individuals

Thursday, April 04 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Targets of IA
Room: Colorado Ballroom

Speaker 7 of 10
Gilda Tachedjian, Burnet Institute, Australia
Vaginal Concentrations of Lactic Acid Potently Inactivate HIV

Thursday, April 04 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Targets of IA
Room: Colorado Ballroom

Speaker 8 of 10
Caroline M. Royle, Imperial College, UK
Comparison of Plasmacytoid Dendritic Cell Activation by HIV-1 and HIV-2: Implications for HIV Immunopathogenesis

Thursday, April 04 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Targets of IA
Room: Colorado Ballroom

Speaker 9 of 10
Jane Rasaiyaah, University College London, UK
Inhibition of HIV-1-Cofactor Interactions Triggers Innate Sensors and Interferon Secretion

Thursday, April 04 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Targets of IA
Room: Colorado Ballroom

Speaker 10 of 10
Molly R. Perkins, Bluebird Bio, USA
Ability of SIVagm-Infected African Green Monkeys to Respond to Neo Antigen and Downregulate CD4

Thursday, April 04 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, April 04 | 5:00PM - 7:00PM
HIV Transmission and Acute Infection
Room: Colorado Ballroom

Speaker 1 of 7
* Michaela Müller-Trutwin, Institut Pasteur, France

Thursday, April 04 | 5:00PM - 7:00PM
HIV Transmission and Acute Infection
Room: Colorado Ballroom

Speaker 2 of 7
* Anthony L. Cunningham, Westmead Institute for Medical Research, Australia

Thursday, April 04 | 5:00PM - 7:00PM
HIV Transmission and Acute Infection
Room: Colorado Ballroom

Speaker 3 of 7
Thomas J. Hope, Northwestern University, USA
Indentification and Characterization of the Initial Targets of Infection in Rhesus Macaque Sex Transmission Models

Thursday, April 04 | 5:00PM - 7:00PM
HIV Transmission and Acute Infection
Room: Colorado Ballroom

Speaker 4 of 7
Gabriella Scarlatti, Global HIV Vaccine Enterprise, USA
Early Events of HIV Transmission at the Intestinal Mucosa and Role of Dendritic Cells

Thursday, April 04 | 5:00PM - 7:00PM
HIV Transmission and Acute Infection
Room: Colorado Ballroom

Speaker 5 of 7
Soni Ramachandra Sankapal, University of Pittsburgh, USA
Short Talk: Unraveling Mechanism of HIV-1 Transmission across Mucosal Epithelia

Thursday, April 04 | 5:00PM - 7:00PM
HIV Transmission and Acute Infection
Room: Colorado Ballroom

Speaker 6 of 7
Sibylle Bernard-Stoecklin, CEA, France
Short Talk: Semen Leukocytes as “Trojan Horses:” Infected CD4+ T Cells and Macrophages Are Present in Semen at Every Stage of SIVmac251 Infection of Cynomolgus macaques

Thursday, April 04 | 5:00PM - 7:00PM
HIV Transmission and Acute Infection
Room: Colorado Ballroom

Speaker 7 of 7
Daniel Claiborne, Ragon Institute of MGH, MIT, and Harvard, USA
Short Talk: Viral Replicative Capacity Contributes Significantly to CD4 Decline Independent of Host Factors

Thursday, April 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Thursday, April 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Breckenridge Ballroom


Friday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Friday, April 05 | 8:00AM - 11:15AM
Viral Reservoirs and Immune Dysfunction
Room: Colorado Ballroom

Speaker 1 of 8
* Eric Hunter, Emory University, USA

Friday, April 05 | 8:00AM - 11:15AM
Viral Reservoirs and Immune Dysfunction
Room: Colorado Ballroom

Speaker 2 of 8
* Greg J. Towers, University College London, UK

Friday, April 05 | 8:00AM - 11:15AM
Viral Reservoirs and Immune Dysfunction
Room: Colorado Ballroom

Speaker 3 of 8
Michael H. Malim, King's College London, UK
Mechanism of Action of the Innate Antiviral Factor APOBEC3G

Friday, April 05 | 8:00AM - 11:15AM
Viral Reservoirs and Immune Dysfunction
Room: Colorado Ballroom

Speaker 4 of 8
Monsef Benkirane, Institut de Genetique Humaine, France
Regulation of Cellular Factors Involved in HIV Virus Gene Expression

Friday, April 05 | 8:00AM - 11:15AM
Viral Reservoirs and Immune Dysfunction
Room: Colorado Ballroom

Speaker 5 of 8
Damian F.J. Purcell, University of Melbourne, Australia
Mechanisms for Tat Expression in Virus Latency that Support T-Cell Activation

Friday, April 05 | 8:00AM - 11:15AM
Viral Reservoirs and Immune Dysfunction
Room: Colorado Ballroom

Speaker 6 of 8
Una O'Doherty, University of Pennsylvania Medical Center, USA
HIV Infected Resting CD4+ T Cells
can Express HIV Proteins and may be Subjected to CTL Clearance


Friday, April 05 | 8:00AM - 11:15AM
Viral Reservoirs and Immune Dysfunction
Room: Colorado Ballroom

Speaker 7 of 8
John C. Tilton, Case Western Reserve University, USA
Short Talk: CD4+ Memory Stem Cells (Tscm) Are Productively and Latently Infected by CCR5- and CXCR4-Tropic HIV

Friday, April 05 | 8:00AM - 11:15AM
Viral Reservoirs and Immune Dysfunction
Room: Colorado Ballroom

Speaker 8 of 8
Anne Hosmalin, Institut Cochin, Inserm U1016, Université Paris Descartes, France
Short Talk: Pro-Inflammatory M-DC8+ ('slan-DC') Monocyte Accumulation in HIV-1-Infected Patients

Friday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, April 05 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Friday, April 05 | 11:15AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Friday, April 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Friday, April 05 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, April 05 | 5:00PM - 7:00PM
Mucosal Immunity and HIV
Room: Colorado Ballroom

Speaker 1 of 6
* Elena Martinelli, Population Council, USA

Friday, April 05 | 5:00PM - 7:00PM
Mucosal Immunity and HIV
Room: Colorado Ballroom

Speaker 2 of 6
* Thomas J. Hope, Northwestern University, USA

Friday, April 05 | 5:00PM - 7:00PM
Mucosal Immunity and HIV
Room: Colorado Ballroom

Speaker 3 of 6
Frederic D. Bushman, University of Pennsylvania, USA
The Human Microbiome in Health and Immunodeficient States

Friday, April 05 | 5:00PM - 7:00PM
Mucosal Immunity and HIV
Room: Colorado Ballroom

Speaker 4 of 6
Jacob D. Estes, Oregon Health and Science University, USA
GI Damage and Immune Activation in SIV

Friday, April 05 | 5:00PM - 7:00PM
Mucosal Immunity and HIV
Room: Colorado Ballroom

Speaker 5 of 6
Maria Rescigno, Humanitas University, Italy
Short Talk: Dendritic Cells in Microbe Interactions in the Gut

Friday, April 05 | 5:00PM - 7:00PM
Mucosal Immunity and HIV
Room: Colorado Ballroom

Speaker 6 of 6
Mirko Paiardini, Emory University, YNPRC, USA
Homeostasis of CD4+ T Cell Subsets in HIV/SIV Infection

Friday, April 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Friday, April 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Breckenridge Ballroom


Saturday, April 06 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Saturday, April 06 | 8:00AM - 11:15AM
Immune Activation and Co-Infections
Room: Colorado Ballroom

Speaker 1 of 8
* Giuseppe Tambussi, San Raffaele Scientific Institute, Italy

Saturday, April 06 | 8:00AM - 11:15AM
Immune Activation and Co-Infections
Room: Colorado Ballroom

Speaker 2 of 8
* Michael M. Lederman, Case Western Reserve University, USA

Saturday, April 06 | 8:00AM - 11:15AM
Immune Activation and Co-Infections
Room: Colorado Ballroom

Speaker 3 of 8
Michael L. Dustin, University of Oxford, UK
Polarized Release and Retroviral Subversion of TCR-Enriched Microvesicles at the T Cell Immunological Synapse

Saturday, April 06 | 8:00AM - 11:15AM
Immune Activation and Co-Infections
Room: Colorado Ballroom

Speaker 4 of 8
Michaela Müller-Trutwin, Institut Pasteur, France
Innate Immune Responses in the Acute Phase of Non-Pathogenic SIVagm Infection

Saturday, April 06 | 8:00AM - 11:15AM
Immune Activation and Co-Infections
Room: Colorado Ballroom

Speaker 5 of 8
Martyn A. French, University of Western Australia, Australia
Immune Reconstitution Inflammatory Syndrome in HIV Infection

Saturday, April 06 | 8:00AM - 11:15AM
Immune Activation and Co-Infections
Room: Colorado Ballroom

Speaker 6 of 8
Richard A. Koup, NIAID, National Institutes of Health, USA
Role of Co-Pathogens in HIV Immune Dysfunction

Saturday, April 06 | 8:00AM - 11:15AM
Immune Activation and Co-Infections
Room: Colorado Ballroom

Speaker 7 of 8
Diana Goode, Population Council, USA
Short Talk: HSV-2 Infection of the Vaginal Mucosa ex vivo Increases the Frequency of alpha4beta7+ T Cells

Saturday, April 06 | 8:00AM - 11:15AM
Immune Activation and Co-Infections
Room: Colorado Ballroom

Speaker 8 of 8
Nathan L. Bowers, University of Alabama, Birmingham, USA
Short Talk: Neutrophils with the Phenotype of Myeloid-Derived Suppressor Cells (MDSCs) Mediate Immune Suppression in HIV-1 Infection

Saturday, April 06 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, April 06 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Saturday, April 06 | 11:15AM - 1:00PM
Poster Setup
Room: Breckenridge Ballroom


Saturday, April 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Breckenridge Ballroom


Saturday, April 06 | 2:30PM - 4:30PM
Workshop 2: Innate and Mucosal Immunity and
their Inte

rplay in HIV/SIV Pathogenesis
Room: Colorado Ballroom

Speaker 1 of 10
* Nicholas Funderburg, Ohio State University, USA

Saturday, April 06 | 2:30PM - 4:30PM
Workshop 2: Innate and Mucosal Immunity and
their Inte

rplay in HIV/SIV Pathogenesis
Room: Colorado Ballroom

Speaker 2 of 10
* Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA

Saturday, April 06 | 2:30PM - 4:30PM
Workshop 2: Innate and Mucosal Immunity and
their Inte

rplay in HIV/SIV Pathogenesis
Room: Colorado Ballroom

Speaker 3 of 10
Elizabeth A. Ihms, Johns Hopkins University, USA
Characterization of Plasma Microparticles during the Host Response to Retroviral Infection

Saturday, April 06 | 2:30PM - 4:30PM
Workshop 2: Innate and Mucosal Immunity and
their Inte

rplay in HIV/SIV Pathogenesis
Room: Colorado Ballroom

Speaker 4 of 10
Anthony L. Cunningham, Westmead Institute for Medical Research, Australia
The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell (DC) Infection, Maturation, Adhesion to T Cells and Viral Transfer

Saturday, April 06 | 2:30PM - 4:30PM
Workshop 2: Innate and Mucosal Immunity and
their Inte

rplay in HIV/SIV Pathogenesis
Room: Colorado Ballroom

Speaker 5 of 10
Amy E. Baxter, University of Pennsylvania, USA
HIV-1 Transmission between Macrophages and T Cells: Consequences for Viral Pathogenesis

Saturday, April 06 | 2:30PM - 4:30PM
Workshop 2: Innate and Mucosal Immunity and
their Inte

rplay in HIV/SIV Pathogenesis
Room: Colorado Ballroom

Speaker 6 of 10
Lucie Barblu, Research Centre of the University of Montreal Hospital Centre, CRCHUM, Canada
Analysis of Myelomonocytic Populations during HIV Infection

Saturday, April 06 | 2:30PM - 4:30PM
Workshop 2: Innate and Mucosal Immunity and
their Inte

rplay in HIV/SIV Pathogenesis
Room: Colorado Ballroom

Speaker 7 of 10
Bruno Vaslin, CEA, France
Plasmacytoid DC Dynamics Tune IFNalpha Production during Acute SIV Infection in Cynomolgus macaques

Saturday, April 06 | 2:30PM - 4:30PM
Workshop 2: Innate and Mucosal Immunity and
their Inte

rplay in HIV/SIV Pathogenesis
Room: Colorado Ballroom

Speaker 8 of 10
Edwin Leeansyah, Karolinska Institutet, Sweden
Activation, Exhaustion and Persistent Decline of the Anti-Microbial MR1-Restricted MAIT Cell Population in Chronic HIV-1 Infection

Saturday, April 06 | 2:30PM - 4:30PM
Workshop 2: Innate and Mucosal Immunity and
their Inte

rplay in HIV/SIV Pathogenesis
Room: Colorado Ballroom

Speaker 9 of 10
Richard M. Dunham, ViiV Healthcare, USA
Immunologic Nonresponders to HAART Have Elevated Systemic Inflammation and Perturbed Intestinal Myeloid Populations

Saturday, April 06 | 2:30PM - 4:30PM
Workshop 2: Innate and Mucosal Immunity and
their Inte

rplay in HIV/SIV Pathogenesis
Room: Colorado Ballroom

Speaker 10 of 10
Irina Grishina, University of California, Davis, USA
SIV Induced Modulation of the Enteric Serotonergic Response Contributes to Chronic Immune Activation

Saturday, April 06 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, April 06 | 5:00PM - 7:00PM
Genetic and Immunological Regulation
Room: Colorado Ballroom

Speaker 1 of 7
* Mary Carrington, NCI, National Institutes of Health, USA

Saturday, April 06 | 5:00PM - 7:00PM
Genetic and Immunological Regulation
Room: Colorado Ballroom

Speaker 2 of 7
* Cristian Apetrei, University of Pittsburgh, USA

Saturday, April 06 | 5:00PM - 7:00PM
Genetic and Immunological Regulation
Room: Colorado Ballroom

Speaker 3 of 7
Philip Tarr, University of Basel, Switzerland
Genetic Associations of Non-Infectious Complications of HIV

Saturday, April 06 | 5:00PM - 7:00PM
Genetic and Immunological Regulation
Room: Colorado Ballroom

Speaker 4 of 7
Lars Pache, Sanford-Burnham Medical Research Institute, USA
Short Talk: Identification of Host Cell Mechanisms Restricting HIV-1 Replication

Saturday, April 06 | 5:00PM - 7:00PM
Genetic and Immunological Regulation
Room: Colorado Ballroom

Speaker 5 of 7
Rui Pedro Galão, King's College London, UK
Short Talk: Mechanistic Insights into Proinflammatory Signaling Induced by Tetherin-Mediated Restriction of Retroviral Release

Saturday, April 06 | 5:00PM - 7:00PM
Genetic and Immunological Regulation
Room: Colorado Ballroom

Speaker 6 of 7
Alan J. Korman, Vir Biotechnology, Inc., USA
Restoration of T Cell Function by Inhibition of Multiple Negative T Cell Regulators

Saturday, April 06 | 5:00PM - 7:00PM
Genetic and Immunological Regulation
Room: Colorado Ballroom

Speaker 7 of 7
Mathieu Angin, Institut Pasteur, France
Short Talk: Impairment of Regulatory T Cell Function Following HIV-1 Infection

Saturday, April 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Saturday, April 06 | 7:30PM - 10:00PM
Poster Session 3
Room: Breckenridge Ballroom


Sunday, April 07 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Sunday, April 07 | 8:00AM - 11:15AM
Immune Activation in Chronic Infection
Room: Colorado Ballroom

Speaker 1 of 8
* Steven G. Deeks, University of California, San Francisco, USA

Sunday, April 07 | 8:00AM - 11:15AM
Immune Activation in Chronic Infection
Room: Colorado Ballroom

Speaker 2 of 8
* Mauro Schechter, Universidade Federal do Rio de Janeiro, Brazil

Sunday, April 07 | 8:00AM - 11:15AM
Immune Activation in Chronic Infection
Room: Colorado Ballroom

Speaker 3 of 8
Nabila Seddiki, Vaccine Research Institute and Université Paris-Est Créteil, France
Role of Regulatory T Cells in HIV Pathogenesis: What's New?

Sunday, April 07 | 8:00AM - 11:15AM
Immune Activation in Chronic Infection
Room: Colorado Ballroom

Speaker 4 of 8
Irini Sereti, NIAID, National Institutes of Health, USA
Biomarkers in HIV Infection

Sunday, April 07 | 8:00AM - 11:15AM
Immune Activation in Chronic Infection
Room: Colorado Ballroom

Speaker 5 of 8
Ivona Pandrea, University of Pittsburgh, USA
Therapeutic Interventions to Modulate Microbial Translocation, Immune Activation and Cardiovascular Comorbidities. Lessons from Non-Human Primate Models

Sunday, April 07 | 8:00AM - 11:15AM
Immune Activation in Chronic Infection
Room: Colorado Ballroom

Speaker 6 of 8
Joel N. Blankson, Johns Hopkins School of Medicine, USA
Viral Reservoirs and Immune Activation Elite Suppressors

Sunday, April 07 | 8:00AM - 11:15AM
Immune Activation in Chronic Infection
Room: Colorado Ballroom

Speaker 7 of 8
Sulggi Angela Lee, University of California, San Francisco, USA
Short Talk: Phenotypic CD8+ T Cell Defects
May Persist in Elite Controllers Despite Viral Control


Sunday, April 07 | 8:00AM - 11:15AM
Immune Activation in Chronic Infection
Room: Colorado Ballroom

Speaker 8 of 8
Karen M. Duus, Albany Medical College, USA
Short Talk: CIITA-Mediated Increased HIV Replication Efficiency Occurs via Two Distinct Cellular Mechanisms

Sunday, April 07 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, April 07 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Sunday, April 07 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Sunday, April 07 | 5:00PM - 7:00PM
Future Directions in Therapeutic Interventions
Room: Colorado Ballroom

Speaker 1 of 5
* Irini Sereti, NIAID, National Institutes of Health, USA

Sunday, April 07 | 5:00PM - 7:00PM
Future Directions in Therapeutic Interventions
Room: Colorado Ballroom

Speaker 2 of 5
* Damian F.J. Purcell, University of Melbourne, Australia

Sunday, April 07 | 5:00PM - 7:00PM
Future Directions in Therapeutic Interventions
Room: Colorado Ballroom

Speaker 3 of 5
Sharon R. Lewin, University of Melbourne, Australia
Clinical Trials for HIV Eradication: The Role of Immune Activation and Immunotherapies

Sunday, April 07 | 5:00PM - 7:00PM
Future Directions in Therapeutic Interventions
Room: Colorado Ballroom

Speaker 4 of 5
Mauro Schechter, Universidade Federal do Rio de Janeiro, Brazil
Preventive Efforts, New Directions beyond Vaccines

Sunday, April 07 | 5:00PM - 7:00PM
Future Directions in Therapeutic Interventions
Room: Colorado Ballroom

Speaker 5 of 5
Steven G. Deeks, University of California, San Francisco, USA
HIV Infection, Inflammation and Aging

Sunday, April 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Sunday, April 07 | 8:00PM - 11:00PM
Entertainment
Room: Breckenridge Ballroom


Sunday, April 07 | 8:00PM - 11:00PM
Cash Bar
Room: Breckenridge Ballroom


Monday, April 08 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.