Web Desc
Cardiac Remodeling, Signaling, Matrix and Heart Function
Organizer(s): Anthony J. Muslin, Jil C. Tardiff and Steven R. Houser
Date: April 07 - 12, 2013
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by Bayer USA Foundation, Novartis Institutes for BioMedical Research and Takeda Pharmaceutical Company Limited
Summary of Meeting:
The general topic of this meeting pertains to anatomic and physiologic changes that contribute to the development of heart failure and cardiac arrhythmias. More specifically, it will highlight recent scientific advances in cardiac biology and heart failure research and relate these insights to the development of novel clinical therapeutics that may impact patient care. This 4-day meeting will bring together both academic and industrial scientists employing state-of-the-art technologies encompassing the fields of stem cell science, tissue regeneration, bioengineering, non-coding RNAs, human and animal genetics, calcium signaling, autophagy and proteolysis, cardiac mechanics, and cardiac matrix biology. The translation of basic scientific discovery to pre-clinical drug development will be emphasized. In addition, there will be a workshop that details recent advances in development of novel therapeutic agents to treat heart failure and arrhythmias. This Keystone Symposia meeting is organized to provide scientists with diverse areas of expertise knowledge of technological applications and biological insights about the development and pathophysiology of cardiac dysfunction and arrhythmias. Interaction between scientists will be promoted through lectures, poster sessions, informal discussions and workshops in an environment that is highly conducive to cross-talk.
Scholarship Deadline: December 5 2012
Discounted Abstract Deadline: December 5 2012
Abstract Deadline: January 9 2013
Discounted Registration Deadline: February 6 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer USA FoundationNovartis Institutes for BioMedical ResearchTakeda Pharmaceutical Company Limited
We gratefully acknowledge additional support for this conference from:
American Heart AssociationCytokinetics, Inc.
InvivoSciences LLC
March of Dimes Foundation Grant No. 4-FY12-556
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Cytokinetics, Inc.

Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL118879-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 07 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Monday, April 08 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, April 08 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Ballroom 2-3

Speaker 2 of 2
Bruce M. Spiegelman, Harvard Medical School, USA
Capturing the Benefits of Exercise at the Molecular Level: Toward a New Generation of Therapeutics

Monday, April 08 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Ballroom 2-3

Speaker 1 of 2
* Anthony J. Muslin, Tectonic Therapeutic, Inc., USA

Monday, April 08 | 9:00AM - 12:00PM
Regenerating Injured Myocardium
Room: Ballroom 2-3

Speaker 5 of 5
Issei Komuro, Tokyo University Graduate School, Japan
Cardiac Angiogenesis and Myogenesis

Monday, April 08 | 9:00AM - 12:00PM
Regenerating Injured Myocardium
Room: Ballroom 2-3

Speaker 4 of 5
William T. Pu, Children's Hospital, Harvard Medical School, USA
Driving Heart Progenitor Cell Fate and Enhancing Cardiac Repair with Chemically Modified RNA

Monday, April 08 | 9:00AM - 12:00PM
Regenerating Injured Myocardium
Room: Ballroom 2-3

Speaker 3 of 5
Young-Jae Nam, University of Texas Southwestern Medical Center, USA
Molecular Strategies for Heart Repair and Regeneration

Monday, April 08 | 9:00AM - 12:00PM
Regenerating Injured Myocardium
Room: Ballroom 2-3

Speaker 2 of 5
Deepak Srivastava, Gladstone Institutes, USA
Reprogramming Approaches for Cardiovascular Disease

Monday, April 08 | 9:00AM - 12:00PM
Regenerating Injured Myocardium
Room: Ballroom 2-3

Speaker 1 of 5
* Anthony J. Muslin, Tectonic Therapeutic, Inc., USA

Monday, April 08 | 9:40AM - 10:00AM
Coffee Break
Room: Ballroom Lobby


Monday, April 08 | 12:00PM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby


Monday, April 08 | 12:00PM - 4:30PM
On Own for Lunch and Recreation


Monday, April 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby


Monday, April 08 | 2:30PM - 4:30PM
Workshop: Use of Human Induced Pluripotent Stem Cells to Mod
el Cardiac Disease
Room: Ballroom 2-3

Speaker 7 of 7
Feng Lan, Stanford Medical School, USA
Abnormal Calcium Handling Properties Underlie Pathogenesis of Familial Hypertrophic Cardiomyopathy in Patient-Specific Induced Pluripotent Stem Cells

Monday, April 08 | 2:30PM - 4:30PM
Workshop: Use of Human Induced Pluripotent Stem Cells to Mod
el Cardiac Disease
Room: Ballroom 2-3

Speaker 6 of 7
Ping Liang, Stanford University, USA
Drug Screening Using a Library of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes Reveals Disease Specific Patterns of Cardiotoxicity

Monday, April 08 | 2:30PM - 4:30PM
Workshop: Use of Human Induced Pluripotent Stem Cells to Mod
el Cardiac Disease
Room: Ballroom 2-3

Speaker 5 of 7
J. Travis Hinson, The Jackson Laboratory, USA
Metabolic Regulation by AMPK in Cardiomyocytes Derived from an iPS Model of PRKAG2-Associated Cardiomyopathy

Monday, April 08 | 2:30PM - 4:30PM
Workshop: Use of Human Induced Pluripotent Stem Cells to Mod
el Cardiac Disease
Room: Ballroom 2-3

Speaker 4 of 7
Marisa Ojala, University of Tampere, Finland
hiPSC Model for Hypertrophic Cardiomyopathy

Monday, April 08 | 2:30PM - 4:30PM
Workshop: Use of Human Induced Pluripotent Stem Cells to Mod
el Cardiac Disease
Room: Ballroom 2-3

Speaker 3 of 7
Rebecca Josowitz, Mount Sinai School of Medicine, USA
Modeling Cardiac Hypertrophy Using Patient Specific iPSC-Derived Cardiomyocytes

Monday, April 08 | 2:30PM - 4:30PM
Workshop: Use of Human Induced Pluripotent Stem Cells to Mod
el Cardiac Disease
Room: Ballroom 2-3

Speaker 2 of 7
Henning Kempf, Hannover Medical School, Germany
Improving Cardiomyogenic Differentiation of Human Pluripotent Stem Cells (hPSC) in Defined Conditions by the Application of Small Molecules

Monday, April 08 | 2:30PM - 4:30PM
Workshop: Use of Human Induced Pluripotent Stem Cells to Mod
el Cardiac Disease
Room: Ballroom 2-3

Speaker 1 of 7
* Jil C. Tardiff, University of Arizona, USA

Monday, April 08 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, April 08 | 5:00PM - 7:00PM
Bioengineering and Tissue Repair
Room: Ballroom 2-3

Speaker 3 of 4
Richard T. Lee, Harvard University, USA
Reversing Myocardial Aging

Monday, April 08 | 5:00PM - 7:00PM
Bioengineering and Tissue Repair
Room: Ballroom 2-3

Speaker 2 of 4
Joseph C. Wu, Stanford University School of Medicine, USA
Imaging Cardiac Stem Cell Biology

Monday, April 08 | 5:00PM - 7:00PM
Bioengineering and Tissue Repair
Room: Ballroom 2-3

Speaker 1 of 4
* Jil C. Tardiff, University of Arizona, USA

Monday, April 08 | 5:00PM - 7:00PM
Bioengineering and Tissue Repair
Room: Ballroom 2-3

Speaker 4 of 4
Josef M. Penninger, Institute of Molecular Biotechnology GmbH, Austria
ACE2 from Cardiovascular Control to Intestinal Inflammation and Malnutrition

Monday, April 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby


Monday, April 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby


Tuesday, April 09 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, April 09 | 8:00AM - 11:00AM
Genetic Causes of Cardiomyopathy
Room: Ballroom 2-3

Speaker 1 of 5
* Jil C. Tardiff, University of Arizona, USA

Tuesday, April 09 | 8:00AM - 11:00AM
Genetic Causes of Cardiomyopathy
Room: Ballroom 2-3

Speaker 2 of 5
Elizabeth M. McNally, Northwestern University, USA
Common and Rare Genetic Variants as Modifiers for Myopathy

Tuesday, April 09 | 8:00AM - 11:00AM
Genetic Causes of Cardiomyopathy
Room: Ballroom 2-3

Speaker 3 of 5
Christine E. Seidman, Harvard Medical School, USA
Modifying Phenotypic Expression in Hypertrophic Cardiomyopathy

Tuesday, April 09 | 8:00AM - 11:00AM
Genetic Causes of Cardiomyopathy
Room: Ballroom 2-3

Speaker 4 of 5
Howard A. Rockman, Duke University Medical Center, USA
The Use of Drosophila Genetic Screens to Investigate Cardiomyopathy

Tuesday, April 09 | 8:00AM - 11:00AM
Genetic Causes of Cardiomyopathy
Room: Ballroom 2-3

Speaker 5 of 5
Xuejun Wang, University of South Dakota, USA
Proteasome Dysfunction in Cardiac Pathogenesis

Tuesday, April 09 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, April 09 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby


Tuesday, April 09 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Tuesday, April 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby


Tuesday, April 09 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, April 09 | 5:00PM - 7:00PM
MicroRNA Regulation of Cardiac Function
Room: Ballroom 2-3

Speaker 1 of 4
* Steven R. Houser, Temple University School of Medicine, USA

Tuesday, April 09 | 5:00PM - 7:00PM
MicroRNA Regulation of Cardiac Function
Room: Ballroom 2-3

Speaker 2 of 4
Gerald W. Dorn, II, Washington University School of Medicine, USA
MicroRNA Regulation of Cardiac Hypertrophy and Failure

Tuesday, April 09 | 5:00PM - 7:00PM
MicroRNA Regulation of Cardiac Function
Room: Ballroom 2-3

Speaker 3 of 4
Edward E. Morrisey, University of Pennsylvania, USA
Promotion of Cardiomyocyte Proliferation by a miRNA-Hippo Mediated Pathway

Tuesday, April 09 | 5:00PM - 7:00PM
MicroRNA Regulation of Cardiac Function
Room: Ballroom 2-3

Speaker 4 of 4
Ronglih Liao, Brigham and Women's Hospital, USA
Unfolding the Misfolded Disease: Molecular Insights into AL Amyloid Cardiomyopathy

Tuesday, April 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby


Tuesday, April 09 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby


Wednesday, April 10 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, April 10 | 8:00AM - 11:00AM
Calcium Signaling, Protein Kinases and Cardiac Dysfunction
Room: Ballroom 2-3

Speaker 1 of 5
* Anthony J. Muslin, Tectonic Therapeutic, Inc., USA

Wednesday, April 10 | 8:00AM - 11:00AM
Calcium Signaling, Protein Kinases and Cardiac Dysfunction
Room: Ballroom 2-3

Speaker 2 of 5
Joan Heller Heller Brown, University of California, San Diego, USA
CaMKIIdelta mediates myocardial ischemia/reperfusion injury through NFkB

Wednesday, April 10 | 8:00AM - 11:00AM
Calcium Signaling, Protein Kinases and Cardiac Dysfunction
Room: Ballroom 2-3

Speaker 3 of 5
Steven R. Houser, Temple University School of Medicine, USA
Microdomain-Based Ca2+ Influx Pathways that Regulate Pathological Hypertrophy and Contractility

Wednesday, April 10 | 8:00AM - 11:00AM
Calcium Signaling, Protein Kinases and Cardiac Dysfunction
Room: Ballroom 2-3

Speaker 4 of 5
Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
Proximal Disease Pathways Underlying Myofiber Necrosis in Muscular Dystrophy

Wednesday, April 10 | 8:00AM - 11:00AM
Calcium Signaling, Protein Kinases and Cardiac Dysfunction
Room: Ballroom 2-3

Speaker 5 of 5
Mark E. Anderson, Johns Hopkins University School of Medicine, USA
Calcium Signaling in Cardiac Arrhythmias

Wednesday, April 10 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Wednesday, April 10 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, April 10 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby


Wednesday, April 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby


Wednesday, April 10 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, April 10 | 5:00PM - 7:00PM
Cardiac Autophagy and Proteolysis
Room: Ballroom 2-3

Speaker 1 of 4
* Steven R. Houser, Temple University School of Medicine, USA

Wednesday, April 10 | 5:00PM - 7:00PM
Cardiac Autophagy and Proteolysis
Room: Ballroom 2-3

Speaker 2 of 4
Norbert Perrimon, Harvard Medical School, USA
A Drosophila Model System to Study Glycogen Autophagy

Wednesday, April 10 | 5:00PM - 7:00PM
Cardiac Autophagy and Proteolysis
Room: Ballroom 2-3

Speaker 3 of 4
Roberta A. Gottlieb, Cedars-Sinai Medical Center, USA
Mitophagy and Cardioprotection: The Heart’s “Cash for Clunkers” Program

Wednesday, April 10 | 5:00PM - 7:00PM
Cardiac Autophagy and Proteolysis
Room: Ballroom 2-3

Speaker 4 of 4
Åsa B. Gustafsson, University of California, San Diego, USA
Mitochondrial Autophagy in Ischemic Myocardium

Wednesday, April 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby


Wednesday, April 10 | 7:30PM - 10:00PM
Poster Session 3
Room: Superior/Superior Lobby


Thursday, April 11 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, April 11 | 8:00AM - 11:00AM
Cardiac Mechanics
Room: Ballroom 2-3

Speaker 1 of 5
* Anthony J. Muslin, Tectonic Therapeutic, Inc., USA

Thursday, April 11 | 8:00AM - 11:00AM
Cardiac Mechanics
Room: Ballroom 2-3

Speaker 2 of 5
Fady Malik, Cytokinetics Inc., USA
Cardiac Myosin Activation for the Treatment of Heart Failure

Thursday, April 11 | 8:00AM - 11:00AM
Cardiac Mechanics
Room: Ballroom 2-3

Speaker 3 of 5
Jil C. Tardiff, University of Arizona, USA
Allosteric Mechanisms in Thin Filament Cardiomyopathies

Thursday, April 11 | 8:00AM - 11:00AM
Cardiac Mechanics
Room: Ballroom 2-3

Speaker 4 of 5
Henk L. Granzier, University of Arizona, USA
The Role of Titin in Cardiac Function and Disease

Thursday, April 11 | 8:00AM - 11:00AM
Cardiac Mechanics
Room: Ballroom 2-3

Speaker 5 of 5
Samantha Harris, University of California, Davis, USA
Functional Mapping of the M-Domain of Cardiac Myosin Binding Protein-C

Thursday, April 11 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Thursday, April 11 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, April 11 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, April 11 | 5:00PM - 7:00PM
Cardiac Extracellular Matrix in Disease
Room: Ballroom 2-3

Speaker 1 of 4
* Steven R. Houser, Temple University School of Medicine, USA

Thursday, April 11 | 5:00PM - 7:00PM
Cardiac Extracellular Matrix in Disease
Room: Ballroom 2-3

Speaker 2 of 4
Walter J. Koch, Temple University School of Medicine, USA
A Dynamic and Critical Relationship between GRK2 and eNOS-NO in Myocardium

Thursday, April 11 | 5:00PM - 7:00PM
Cardiac Extracellular Matrix in Disease
Room: Ballroom 2-3

Speaker 3 of 4
Thomas Eschenhagen, University Medical Center Hamburg-Eppendorf, Germany
Cardiac Tissue Engineering for Disease Modeling

Thursday, April 11 | 5:00PM - 7:00PM
Cardiac Extracellular Matrix in Disease
Room: Ballroom 2-3

Speaker 4 of 4
Anthony J. Muslin, Tectonic Therapeutic, Inc., USA
Developing Drugs to Reduce Cardiac Fibrosis and Improve Function

Thursday, April 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 2-3


Thursday, April 11 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2-3


Thursday, April 11 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 2-3


Friday, April 12 | 10:25AM - 10:25AM
Departure


*Session Chair.