Web Desc
The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer
Organizer(s): Marius Sudol, Helen McNeill, Georg A. Halder and Giovanni Blandino
Date: May 19 - 23, 2013
Location: Hyatt Regency Monterey, Monterey, CA, USA
Supported by the Directors' Fund
Summary of Meeting:
Over the past several years, the Hippo tumor suppressor pathway has emerged as a complex signaling network that has significant implications for our understanding of the molecular mechanisms of cancer development and stem cell biology. The main effectors of this pathway, YAP and TAZ, are transcriptional co- activators, which act as stemness factors and potent oncogenes. Recent studies have revealed that abnormal expression of components of the network can lead to cancer. Therefore, the pathway and its networking molecules are attractive targets for the development of cancer drugs and unconventional therapeutic interventions. Several paradoxes have emerged in the field in recent years, and fast progress in this field is due, in large part, to an active dialog between Drosophila geneticists and mammalian signalers. The overwhelming interest of researchers in the function of the Hippo pathway in stem cells and cancer prompted us to seek a larger forum. At the Keystone Symposia meeting on The Hippo Tumor Suppressor Network we aim to: (i) Define why YAP and TAZ function as either oncogenes or tumor suppressors; (ii) Identify membrane complexes, which activate the Hippo pathway in mammals, as the orthology with the fly receptors is not clear; (iii) Define targets for small molecule inhibitors and activators within pathway components based on structured modules, including WW, PDZ and SARAH domains. The meeting will be unique in bringing together Drosophila geneticists, basic and clinical cancer researchers, and the stem cell research community. We anticipate that this meeting will help to consolidate the emerging field and have an impact on development of new cancer therapies.
Scholarship Deadline: January 17 2013
Discounted Abstract Deadline: January 17 2013
Abstract Deadline: February 18 2013
Discounted Registration Deadline: March 19 2013
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA177113-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, May 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Regency Grand Foyer


Monday, May 20 | 7:00AM - 8:00AM
Breakfast
Room: Regency Grand IV-VI


Monday, May 20 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Regency Grand I-III

Speaker 1 of 2
* Joe L. Kissil, The Scripps Research Institute, USA

Monday, May 20 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Regency Grand I-III

Speaker 2 of 2
Kun-Liang Guan, University of California, San Diego, USA
Regulation of YAP/TAZ in the Hippo Pathway by G-Protein Coupled Receptor Signaling

Monday, May 20 | 9:00AM - 11:30AM
Membrane and Upstream Signals
Room: Regency Grand I-III

Speaker 1 of 6
* Nicolas Tapon, Francis Crick Institute, UK

Monday, May 20 | 9:00AM - 11:30AM
Membrane and Upstream Signals
Room: Regency Grand I-III

Speaker 2 of 6
Helen McNeill, Lunenfeld-Tanenbaum Research Institute, Canada
YAP and Fat Cadherins in Kidney Development

Monday, May 20 | 9:00AM - 11:30AM
Membrane and Upstream Signals
Room: Regency Grand I-III

Speaker 3 of 6
Fernando D. Camargo, Boston Children's Hospital, USA
Hippo/YAP Signaling in Somatic Stem Cells

Monday, May 20 | 9:00AM - 11:30AM
Membrane and Upstream Signals
Room: Regency Grand I-III

Speaker 4 of 6
Tony Pawson, Samuel Lunenfeld Research Institute, Canada
Regulation of Rho GTPases and Kinases in Hippo Signaling

Monday, May 20 | 9:00AM - 11:30AM
Membrane and Upstream Signals
Room: Regency Grand I-III

Speaker 5 of 6
Jacob J. Adler, Indiana University School of Medicine, USA
Short Talk: Amot Adapts the Ubiquitin Ligase AIP4 to Inhibit YAP Signaling and Cell Growth

Monday, May 20 | 9:00AM - 11:30AM
Membrane and Upstream Signals
Room: Regency Grand I-III

Speaker 6 of 6
Isabel Serrano, British Columbia Cancer Research Center, Canada
Short Talk: Integrin-Liked Kinase (ILK) Is a Critical Regulator of the Hippo/YAP Signaling Pathway

Monday, May 20 | 9:40AM - 10:00AM
Coffee Break
Room: Regency Grand Foyer


Monday, May 20 | 11:30AM - 1:00PM
Poster Setup
Room: Regency Grand IV-VI


Monday, May 20 | 11:30AM - 4:30PM
On Own for Lunch and Recreation


Monday, May 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Regency Grand IV-VI


Monday, May 20 | 4:30PM - 5:00PM
Coffee Available
Room: Regency Grand Foyer


Monday, May 20 | 5:00PM - 7:00PM
Hippo in Flies and Mammals: Orthology and Diversity
Room: Regency Grand I-III

Speaker 1 of 6
* Helen McNeill, Lunenfeld-Tanenbaum Research Institute, Canada

Monday, May 20 | 5:00PM - 7:00PM
Hippo in Flies and Mammals: Orthology and Diversity
Room: Regency Grand I-III

Speaker 2 of 6
* Yosef Shaul, Weizmann Institute of Science, Israel

Monday, May 20 | 5:00PM - 7:00PM
Hippo in Flies and Mammals: Orthology and Diversity
Room: Regency Grand I-III

Speaker 3 of 6
Duojia D.J. Pan, HHMI/Johns Hopkins University School of Medicine, USA
Control of Organ Size and Tumorigenesis by the Hippo Signaling Pathway

Monday, May 20 | 5:00PM - 7:00PM
Hippo in Flies and Mammals: Orthology and Diversity
Room: Regency Grand I-III

Speaker 4 of 6
Nicolas Tapon, Francis Crick Institute, UK
Screening for New Hippo Tumor Suppressor Pathway Regulators

Monday, May 20 | 5:00PM - 7:00PM
Hippo in Flies and Mammals: Orthology and Diversity
Room: Regency Grand I-III

Speaker 5 of 6
Joan S. Brugge, Harvard Medical School, USA
The Role of YAP Oncogene in Cytokinesis

Monday, May 20 | 5:00PM - 7:00PM
Hippo in Flies and Mammals: Orthology and Diversity
Room: Regency Grand I-III

Speaker 6 of 6
Jeffrey Schindler, Massachusetts Institute of Technology, USA
Short Talk: Determining the Role of Merlin Isoforms in Upstream Regulation of YAP

Monday, May 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Regency Grand IV-VI


Monday, May 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Regency Grand IV-VI


Tuesday, May 21 | 7:00AM - 8:00AM
Breakfast
Room: Regency Grand IV-VI


Tuesday, May 21 | 8:00AM - 11:15AM
Junctional Complexes and the Hippo Pathway
Room: Regency Grand I-III

Speaker 1 of 8
* Filippo G. Giancotti, Memorial Sloan-Kettering Cancer Center, USA

Tuesday, May 21 | 8:00AM - 11:15AM
Junctional Complexes and the Hippo Pathway
Room: Regency Grand I-III

Speaker 2 of 8
* Sabrina Strano, Regina Elena National Cancer Institute, Italy

Tuesday, May 21 | 8:00AM - 11:15AM
Junctional Complexes and the Hippo Pathway
Room: Regency Grand I-III

Speaker 3 of 8
Joe L. Kissil, The Scripps Research Institute, USA
The Role of Angiomotins and Merlin in Regulation of the Hippo Pathway

Tuesday, May 21 | 8:00AM - 11:15AM
Junctional Complexes and the Hippo Pathway
Room: Regency Grand I-III

Speaker 4 of 8
Wanjin Hong, Institute of Molecular and Cell Biology, Singapore
Angiomotins as Substrates of Hippo Core Kinases

Tuesday, May 21 | 8:00AM - 11:15AM
Junctional Complexes and the Hippo Pathway
Room: Regency Grand I-III

Speaker 5 of 8
Yosef Shaul, Weizmann Institute of Science, Israel
Why Crowded Cell Cultures Are Radioresistant: A Direct Cross-Talk between Hippo and DNA Damage Response Pathways

Tuesday, May 21 | 8:00AM - 11:15AM
Junctional Complexes and the Hippo Pathway
Room: Regency Grand I-III

Speaker 6 of 8
Hiroshi Sasaki, Osaka University, Japan
Mechanisms of Position-Dependent Specification of Cell Fates in Preimplantation Embryos

Tuesday, May 21 | 8:00AM - 11:15AM
Junctional Complexes and the Hippo Pathway
Room: Regency Grand I-III

Speaker 7 of 8
Georgina C. Fletcher, Cancer Research UK, UK
Short Talk: Positive Feedback and Mutual Antagonism Combine to Polarize Crumbs in the Drosophila Follicle Cell Epithelium

Tuesday, May 21 | 8:00AM - 11:15AM
Junctional Complexes and the Hippo Pathway
Room: Regency Grand I-III

Speaker 8 of 8
Bernhard Schermer, University Hospital of Cologne, Germany
Short Talk: Nephrocystin Proteins Control Nuclear Translocation and Activation of YAP/TAZ Implicating Deregulated Hippo Signaling in the Pathogenesis of Cystic Kidney Disease and Related Ciliopathies

Tuesday, May 21 | 9:20AM - 9:40AM
Coffee Break
Room: Regency Grand Foyer


Tuesday, May 21 | 11:15AM - 1:00PM
Poster Setup
Room: Regency Grand IV-VI


Tuesday, May 21 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Tuesday, May 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Regency Grand IV-VI


Tuesday, May 21 | 4:30PM - 5:00PM
Coffee Available
Room: Regency Grand Foyer


Tuesday, May 21 | 5:00PM - 7:00PM
Hippo Network in Organ Size Control
Room: Regency Grand I-III

Speaker 1 of 6
* Kenneth Irvine, Rutgers University, USA

Tuesday, May 21 | 5:00PM - 7:00PM
Hippo Network in Organ Size Control
Room: Regency Grand I-III

Speaker 2 of 6
* Giovanni Blandino, Regina Elena Cancer Institute, Italy

Tuesday, May 21 | 5:00PM - 7:00PM
Hippo Network in Organ Size Control
Room: Regency Grand I-III

Speaker 3 of 6
Junichi Sadoshima, Rutgers New Jersey Medical School, USA
Coordinated Regulation of Autophagy and Apoptosis by Mst1 in Cardiomyocytes

Tuesday, May 21 | 5:00PM - 7:00PM
Hippo Network in Organ Size Control
Room: Regency Grand I-III

Speaker 4 of 6
Georg A. Halder, Katholieke Universiteit Leuven, Belgium
Mask Is Required for the Activity of the Hippo Pathway Effector Yki/YAP

Tuesday, May 21 | 5:00PM - 7:00PM
Hippo Network in Organ Size Control
Room: Regency Grand I-III

Speaker 5 of 6
Stefano Piccolo, University of Padua, Italy
Regulation of TAZ and YAP by Wnt Signaling and Cell Shape

Tuesday, May 21 | 5:00PM - 7:00PM
Hippo Network in Organ Size Control
Room: Regency Grand I-III

Speaker 6 of 6
Diane D. Shao, Harvard Medical School, USA
Short Talk: Genome-Scale Expression Screen Reveals Role for YAP1 in KRAS Oncogenic Addiction

Tuesday, May 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Regency Grand IV-VI


Tuesday, May 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Regency Grand IV-VI


Wednesday, May 22 | 7:00AM - 8:00AM
Breakfast
Room: Regency Grand IV-VI


Wednesday, May 22 | 8:00AM - 11:15AM
Deregulation of Hippo Pathway in Cancer
Room: Regency Grand I-III

Speaker 1 of 8
* Georg A. Halder, Katholieke Universiteit Leuven, Belgium

Wednesday, May 22 | 8:00AM - 11:15AM
Deregulation of Hippo Pathway in Cancer
Room: Regency Grand I-III

Speaker 2 of 8
* Duojia D.J. Pan, HHMI/Johns Hopkins University School of Medicine, USA

Wednesday, May 22 | 8:00AM - 11:15AM
Deregulation of Hippo Pathway in Cancer
Room: Regency Grand I-III

Speaker 3 of 8
Kieran F. Harvey, Peter MacCallum Cancer Centre, Australia
Control of Tissue Growth by the Hippo Pathway

Wednesday, May 22 | 8:00AM - 11:15AM
Deregulation of Hippo Pathway in Cancer
Room: Regency Grand I-III

Speaker 4 of 8
Yael Aylon, Weizmann Institute of Science, Israel
The Lats2-p53 Tumor Suppressor Axis

Wednesday, May 22 | 8:00AM - 11:15AM
Deregulation of Hippo Pathway in Cancer
Room: Regency Grand I-III

Speaker 5 of 8
Giovanni Blandino, Regina Elena Cancer Institute, Italy
Crosstalk between p53 Family and YAP in DNA Damage and Senescence

Wednesday, May 22 | 8:00AM - 11:15AM
Deregulation of Hippo Pathway in Cancer
Room: Regency Grand I-III

Speaker 6 of 8
Filippo G. Giancotti, Memorial Sloan-Kettering Cancer Center, USA
Molecular Underpinnings of Merlin-Mediated Tumor Suppression in Mammals

Wednesday, May 22 | 8:00AM - 11:15AM
Deregulation of Hippo Pathway in Cancer
Room: Regency Grand I-III

Speaker 7 of 8
Cathie M. Pfleger, Mount Sinai School of Medicine, USA
Short Talk: Dietary Alcohol Enhances Tissue Overgrowth Associated with Loss of Hippo Signaling But Not Over-Expression of Yorkie

Wednesday, May 22 | 8:00AM - 11:15AM
Deregulation of Hippo Pathway in Cancer
Room: Regency Grand I-III

Speaker 8 of 8
Yiting Qiao, Cancer Science Institute, Singapore
Short Talk: The Interplay between RUNX3 and TEADs in Gastric Cancer

Wednesday, May 22 | 9:20AM - 9:40AM
Coffee Break
Room: Regency Grand Foyer


Wednesday, May 22 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Wednesday, May 22 | 4:30PM - 5:00PM
Coffee Available
Room: Regency Grand Foyer


Wednesday, May 22 | 5:00PM - 6:10PM
From Structure-Function Analysis to Details of the Mechanism
s that Govern Hippo Signaling

Room: Regency Grand I-III

Speaker 1 of 3
* Fernando D. Camargo, Boston Children's Hospital, USA

Wednesday, May 22 | 5:00PM - 6:10PM
From Structure-Function Analysis to Details of the Mechanism
s that Govern Hippo Signaling

Room: Regency Grand I-III

Speaker 2 of 3
Xaralabos (Bob) Varelas, Boston University School of Medicine, USA
Crosstalk between the Hippo and TGFbeta Pathways Directs Tumor-Initiating Signals

Wednesday, May 22 | 5:00PM - 6:10PM
From Structure-Function Analysis to Details of the Mechanism
s that Govern Hippo Signaling

Room: Regency Grand I-III

Speaker 3 of 3
Marius Sudol, National University of Singapore, Singapore
Hippo Pathway as the WW Domain-Mediated Network of Signals


Wednesday, May 22 | 6:10PM - 7:00PM
Closing Keynote Address
Room: Regency Grand I-III

Speaker 1 of 1
Joseph Avruch, Massachusetts General Hospital, USA
The Mammalian Hippo Tumor Suppressor Pathway-Negative Regulation of the YAP Oncogene

Wednesday, May 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Regency Grand IV-VI


Wednesday, May 22 | 8:00PM - 11:00PM
Entertainment
Room: Regency Grand IV-VI


Wednesday, May 22 | 9:00PM - 11:00PM
Cash Bar
Room: Regency Grand IV-VI


Thursday, May 23 | 10:25AM - 10:25AM
Departure


*Session Chair.