Web Desc
Human Genomics and Personalized Medicine
Organizer(s): Kelly A. Frazer and Geoffrey S. Ginsburg
Date: June 17 - 21, 2013
Location: Clarion Hotel Sign, Stockholm, Sweden
Organized in collaboration with Knut and Alice Wallenberg Foundation and Science for Life Laboratory - Stockholm. Sponsored by AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., H3 Biomedicine Inc., Nestlé Institute of Health Sciences and Onyx Pharmaceuticals, Inc.
Summary of Meeting:
The last decade has seen considerable progress in our understanding of genomics and the era of personalized medicine is just around the corner. Importantly, emerging data on the structure and function of the human genome are providing insights into the molecular basis of inherited disease and providing opportunities to improve human health through new approaches to diagnostics and therapy. These advances will impact all aspects of human health, ranging from cancer to other chronic diseases. Making genomic medicine a reality requires novel collaborations between basic scientists, translational scientist, regulatory bodies and health insurance bodies. Therefore, the Keystone Symposia meeting on Human Genomics and Personalized Medicine is a timely opportunity to bring leading researchers together to discuss the critical issues facing this emerging field. The meeting will focus on various aspects of the field, including genomics and the transition to genomic medicine (clinical care based on genomic information), the analysis of complex data sets, the development of robust bio-repositories, public access to large data sets being generated from funds from NIH and other agencies, and key regulatory issues and public policy. Importantly, the meeting will help establish communication and interactions enabling a faster implementation of genomic medicine and will also benefit from its international participation by highlighting areas of research that are of global concern.
Scholarship Deadline: February 20 2013
Discounted Abstract Deadline: February 20 2013
Abstract Deadline: March 19 2013
Discounted Registration Deadline: April 16 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZenecaBoehringer Ingelheim Pharmaceuticals, Inc.H3 Biomedicine Inc.Nestlé Institute of Health SciencesOnyx Pharmaceuticals, Inc.Science for Life Laboratory - StockholmKnut and Alice Wallenberg Foundation
We gratefully acknowledge additional support for this conference from:

Science Translational Medicine
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Institutes for BioMedical Research
$2,500 - $9,999
S. Karger AG - ISCN 2013
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
S. Karger AG - ISCN 2013
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, June 17 | 12:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Monday, June 17 | 3:30PM - 4:00PM
Coffee & Snacks Available
Room: Foyer


Monday, June 17 | 4:00PM - 5:00PM
Welcome and Keynote Address
Room: B 1-2

Speaker 1 of 2
* Geoffrey S. Ginsburg, Duke University, USA
Welcome Remarks

Monday, June 17 | 4:00PM - 5:00PM
Welcome and Keynote Address
Room: B 1-2

Speaker 2 of 2
John Bell, University of Oxford, UK
Bringing Genomics to the Bedside

Monday, June 17 | 5:00PM - 7:00PM
Breakthroughs in Genomic and Personalized Medicine
Room: B 1-2

Speaker 1 of 4
* Kelly A. Frazer, University of California San Diego School of Medicine, USA

Monday, June 17 | 5:00PM - 7:00PM
Breakthroughs in Genomic and Personalized Medicine
Room: B 1-2

Speaker 2 of 4
Peter Mueller, Mueller Health Foundation, USA
Kalydeco: Targeting the G551D Mutation in CF

Monday, June 17 | 5:00PM - 7:00PM
Breakthroughs in Genomic and Personalized Medicine
Room: B 1-2

Speaker 3 of 4
Geoffrey S. Ginsburg, Duke University, USA
Novel Host-Based Approaches to the Diagnosis of Infectious Disease

Monday, June 17 | 5:00PM - 7:00PM
Breakthroughs in Genomic and Personalized Medicine
Room: B 1-2

Speaker 4 of 4
Stephen F. Kingsmore, Rady Children's Institute for Genomic Medicine, USA
Pediatric Genomic Medicine

Tuesday, June 18 | 6:30AM - 12:00PM
On Own for Dinner


Tuesday, June 18 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Tuesday, June 18 | 7:30AM - 8:00AM
Poster Setup
Room: B3


Tuesday, June 18 | 8:00AM - 3:30PM
Poster Viewing
Room: B3


Tuesday, June 18 | 8:30AM - 11:30AM
Genomes and Biology
Room: B 1-2

Speaker 1 of 6
* Thomas J. Hudson, AbbVie, Inc., USA

Tuesday, June 18 | 8:30AM - 11:30AM
Genomes and Biology
Room: B 1-2

Speaker 2 of 6
Mathias Uhlen, KTH Royal Inst of Technology, Sweden
Defining the Human Tissue-Specific Proteome based on Transcriptomics and Antibody-Based Protein Profiling

Tuesday, June 18 | 8:30AM - 11:30AM
Genomes and Biology
Room: B 1-2

Speaker 3 of 6
Kelly A. Frazer, University of California San Diego School of Medicine, USA
Genomic Approaches to Understanding Cancer Progression

Tuesday, June 18 | 8:30AM - 11:30AM
Genomes and Biology
Room: B 1-2

Speaker 4 of 6
Martin J. Blaser, New York University School of Medicine, USA
Perturbing the Early Life Microbiome and its Consequences

Tuesday, June 18 | 8:30AM - 11:30AM
Genomes and Biology
Room: B 1-2

Speaker 5 of 6
Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA
The Epigenetic Basis of Common Human Disease

Tuesday, June 18 | 8:30AM - 11:30AM
Genomes and Biology
Room: B 1-2

Speaker 6 of 6
Lili Milani, University of Tartu, Estonia
Short Talk: Genome-Wide DNA Methylation and Gene Expression Changes in Whole Blood, CD4+ and CD8+ T-Cells during Healthy Aging

Tuesday, June 18 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer/Hyllan


Tuesday, June 18 | 11:30AM - 12:30PM
Lunch
Room: Atrium/Foyer


Tuesday, June 18 | 12:30PM - 3:00PM
Poster Session 1
Room: B3


Tuesday, June 18 | 3:00PM - 3:30PM
Coffee Available
Room: Foyer/Hyllan


Tuesday, June 18 | 3:30PM - 6:30PM
Cancer Genomics and Applications
Room: B 1-2

Speaker 1 of 6
* Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA

Tuesday, June 18 | 3:30PM - 6:30PM
Cancer Genomics and Applications
Room: B 1-2

Speaker 2 of 6
Paul S. Mischel, University of California, San Diego, USA
The Cancer Genome Atlas and the Future of Cancer Diagnosis and Treatment



Tuesday, June 18 | 3:30PM - 6:30PM
Cancer Genomics and Applications
Room: B 1-2

Speaker 3 of 6
Thomas J. Hudson, AbbVie, Inc., USA
Linking Cancer Treatment Decisions with Large-Scale Mutation Surveys

Tuesday, June 18 | 3:30PM - 6:30PM
Cancer Genomics and Applications
Room: B 1-2

Speaker 4 of 6
Jessica Nordlund, Uppsala University, Sweden
Short Talk: The DNA Methylation Landscape of Pediatric Acute Lymphoblastic Leukemia

Tuesday, June 18 | 3:30PM - 6:30PM
Cancer Genomics and Applications
Room: B 1-2

Speaker 5 of 6
Steven Shak, Genomic Health Inc., USA
Translating Genomics into Clinical Practice: Lessons from Oncotype DX

Tuesday, June 18 | 3:30PM - 6:30PM
Cancer Genomics and Applications
Room: B 1-2

Speaker 6 of 6
Hiroyuki Mano, University of Tokyo, Japan
Targeting Essential Growth Drivers in Human Cancer

Wednesday, June 19 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Wednesday, June 19 | 8:30AM - 11:30AM
Advances and Challenges in the Field
Room: B 1-2

Speaker 1 of 6
* Kelly A. Frazer, University of California San Diego School of Medicine, USA

Wednesday, June 19 | 8:30AM - 11:30AM
Advances and Challenges in the Field
Room: B 1-2

Speaker 2 of 6
Janet Woodcock, US Food and Drug Administration, USA
A Regulatory Pathway to Personalized Medicine

Wednesday, June 19 | 8:30AM - 11:30AM
Advances and Challenges in the Field
Room: B 1-2

Speaker 3 of 6
Dan M. Roden, Vanderbilt University Medical Center, USA
Integration and Implementation of Genetic Information into Health Systems

Wednesday, June 19 | 8:30AM - 11:30AM
Advances and Challenges in the Field
Room: B 1-2

Speaker 4 of 6
Jill P. Mesirov, Broad Institute, USA
Computational Approaches for Genomic Medicine

Wednesday, June 19 | 8:30AM - 11:30AM
Advances and Challenges in the Field
Room: B 1-2

Speaker 5 of 6
Howard J. Jacob, HudsonAlpha Institute for Bioltechnology, USA
Advances in Clinical Sequencing

Wednesday, June 19 | 8:30AM - 11:30AM
Advances and Challenges in the Field
Room: B 1-2

Speaker 6 of 6
X. Sunney Xie, Peking University, China
Short Talk: Single-Cell Genomics: Life at the Single Molecule Level

Wednesday, June 19 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer/Hyllan


Wednesday, June 19 | 11:30AM - 1:00PM
Poster Setup
Room: B3


Wednesday, June 19 | 11:30AM - 12:30PM
Lunch
Room: Atrium/Foyer


Wednesday, June 19 | 12:30PM - 10:00PM
Poster Viewing
Room: B3


Wednesday, June 19 | 12:30PM - 3:00PM
Pharmacogenomics
Room: B 1-2

Speaker 1 of 6
* Dan M. Roden, Vanderbilt University Medical Center, USA

Wednesday, June 19 | 12:30PM - 3:00PM
Pharmacogenomics
Room: B 1-2

Speaker 2 of 6
Alan R. Shuldiner, Regeneron Pharmaceuticals, Inc, USA
Genomic Management of Anti-Platelet Therapeutics

Wednesday, June 19 | 12:30PM - 3:00PM
Pharmacogenomics
Room: B 1-2

Speaker 3 of 6
Y.T. Chen, Duke University, USA
Realizing the Promise of Personalized Medicine: HLA-B*1502 Screen in Preventing Carbamazepine-Induced Toxic Effects


Wednesday, June 19 | 12:30PM - 3:00PM
Pharmacogenomics
Room: B 1-2

Speaker 4 of 6
Keith J. Johnson, Novartis Institutes for BioMedical Research, Inc., USA
Pharmacogenetic Applications to Enable Drug Development for General Medicine Indications

Wednesday, June 19 | 12:30PM - 3:00PM
Pharmacogenomics
Room: B 1-2

Speaker 5 of 6
Federico Innocenti, University of North Carolina at Chapel Hill, USA
Pharmacogenetics of Cancer Therapeutics: Focus on the Germline Genome

Wednesday, June 19 | 12:30PM - 3:00PM
Pharmacogenomics
Room: B 1-2

Speaker 6 of 6
Shannon Gibson, University of Toronto, Canada
Short Talk: Ethical, Legal and Social Issues in Pharmacogenomics: A Qualitative Study of the Perspectives of Canadian Stakeholders

Wednesday, June 19 | 3:00PM - 3:30PM
Coffee Available
Room: Foyer/Hyllan


Wednesday, June 19 | 3:30PM - 5:30PM
Personalized Genomes
Room: B 1-2

Speaker 1 of 5
* Howard J. Jacob, HudsonAlpha Institute for Bioltechnology, USA

Wednesday, June 19 | 3:30PM - 5:30PM
Personalized Genomes
Room: B 1-2

Speaker 2 of 5
Michael P. Snyder, Stanford University School of Medicine, USA
Adventures in Personal Genomics: iPOP of Healthy and Disease States

Wednesday, June 19 | 3:30PM - 5:30PM
Personalized Genomes
Room: B 1-2

Speaker 3 of 5
William A. Gahl, NHGRI, National Institutes of Health, USA
Whole Exome Sequencing for Undiagnosed Diseases

Wednesday, June 19 | 3:30PM - 5:30PM
Personalized Genomes
Room: B 1-2

Speaker 4 of 5
Alan H. Bryce, Mayo Clinic, USA
Short Talk: A Pilot Study of Whole Genome, Whole Exome and RNA Sequencing with CLIA Validation to Identify Potential Therapeutic Targets in Advanced Cancer Patients

Wednesday, June 19 | 3:30PM - 5:30PM
Personalized Genomes
Room: B 1-2

Speaker 5 of 5
George M. Church, Harvard Medical School, USA
The Personal Genome Project and the Future of Medicine

Wednesday, June 19 | 5:30PM - 6:30PM
Social Hour with Lite Bites
Room: Atrium/Foyer


Wednesday, June 19 | 6:30PM - 9:00PM
Poster Session 2
Room: B3


Thursday, June 20 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Thursday, June 20 | 8:30AM - 11:30AM
Policy
Room: B 1-2

Speaker 1 of 6
* Janet Woodcock, US Food and Drug Administration, USA

Thursday, June 20 | 8:30AM - 11:30AM
Policy
Room: B 1-2

Speaker 2 of 6
Susanne B. Haga, Duke University, USA
Introducing Genomics in the Clinic: Development of New Delivery Systems

Thursday, June 20 | 8:30AM - 11:30AM
Policy
Room: B 1-2

Speaker 3 of 6
Laura Lyman Rodriguez, NHGRI, National Institutes of Health, USA
Bringing Genomics into Medicine: Advancing the Policy Agenda

Thursday, June 20 | 8:30AM - 11:30AM
Policy
Room: B 1-2

Speaker 4 of 6
Andelka M. Phillips, University of Oxford, UK
Short Talk: We Agree to Sequence your Genomic Data, and you Agree to X, Y, Z…

Thursday, June 20 | 8:30AM - 11:30AM
Policy
Room: B 1-2

Speaker 5 of 6
Katherine Payne, University of Manchester, UK
Quantifying the Economic Value of Personalized Medicine

Thursday, June 20 | 8:30AM - 11:30AM
Policy
Room: B 1-2

Speaker 6 of 6
Jane Kaye, University of Oxford, UK
Privacy, Data-Sharing Frameworks, Global Governance and Translational Research

Thursday, June 20 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer/Hyllan


Thursday, June 20 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, June 20 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer/Hyllan


Thursday, June 20 | 5:00PM - 7:00PM
Translating Biomarkers to Personalized Medicine
Room: B 1-2

Speaker 1 of 4
* Geoffrey S. Ginsburg, Duke University, USA

Thursday, June 20 | 5:00PM - 7:00PM
Translating Biomarkers to Personalized Medicine
Room: B 1-2

Speaker 2 of 4
Michelle Penny, Biogen, USA
Integration of Genomic Technologies into Drug Discovery and Development

Thursday, June 20 | 5:00PM - 7:00PM
Translating Biomarkers to Personalized Medicine
Room: B 1-2

Speaker 3 of 4
Johan Lundin, University of Helsinki, Finland
Developing Diagnostics from Biomarkers

Thursday, June 20 | 5:00PM - 7:00PM
Translating Biomarkers to Personalized Medicine
Room: B 1-2

Speaker 4 of 4
Thomas Metcalfe, Oncotest GmbH - Institute for Experimental Oncology, Germany
Co-Development of Therapeutics and Companion Diagnostics

Thursday, June 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Atrium/Foyer


Thursday, June 20 | 8:00PM - 11:00PM
Entertainment
Room: B 1-3


Thursday, June 20 | 8:00PM - 11:00PM
Cash Bar
Room: B 1-3


Friday, June 21 | 10:25AM - 10:25AM
Departure


*Session Chair.