Web Desc
Pathogenic Processes in Asthma and COPD
joint with Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology
Organizer(s): Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston
Date: January 10 - 15, 2013
Location: Santa Fe Community Convention Center, Santa Fe, NM, USA
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Chronic obstructive pulmonary disease (COPD) and asthma continue to be important causes of morbidity, mortality, and healthcare costs worldwide. However, the underlying causes of asthma and COPD remain poorly understood, even as the incidence of such diseases continues to increase. Recent discoveries have uncovered strong associations between both lung function and immune responses in early life and the subsequent development of persistent asthma and chronic airway obstruction in adulthood. However, to date, no meeting has taken advantage of these recent discoveries. The overall goal of this meeting is to draw together investigators from multiple disciplines doing work relevant to understanding the genetic, epigenetic and environmental factors and mechanisms that affect the development of asthma and COPD. The specific goals of the meeting are to: 1) explore recent insights into the genetic and epigenetic origins of asthma and COPD; 2) understand the relationship between early life environmental exposures and impaired lung function throughout life; 3) understand the relationship between lung infections as well as changes in the intestinal microbiome and the development of chronic lung diseases; 4) understand the role of newly described innate immune cell populations and pathways in the development of lung inflammation; 5) understand recent insights into the mechanisms of lung development, repair and remodeling; and 6) explore unique pathways of resolution of lung inflammation. By bringing together a critical mass of multidisciplinary researchers, this symposium should provide an ideal forum for exploring novel prevention and treatment strategies for these chronic respiratory diseases based on the identification of the genetic and environmental factors that interactively cause these disorders. Moreover, this meeting will serve to provide an in-depth exposure for junior investigators (graduate students and post-docs) to a fast-moving, fruitful area of medical research, as well as enticing such scientists into the field. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology, which will share a keynote address and two plenary sessions with this meeting.
Scholarship Deadline: September 10 2012
Discounted Abstract Deadline: September 10 2012
Abstract Deadline: October 10 2012
Discounted Registration Deadline: November 8 2012
Abstacts when book is in proofing process


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Thursday, January 10 | 3:00PM - 7:30PM
Arrival and Registration
Room: Sweeney Ballroom Foyer


Thursday, January 10 | 6:15PM - 7:15PM
Refreshments
Room: Sweeney F, Main Level Breakouts


Thursday, January 10 | 7:15PM - 8:30PM
Welcome and Keynote Address (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 1
Bart N. Lambrecht, VIB, Ghent University, Belgium
The Lung Dendritic Cell Network and the Response to Allergens

Friday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Main Level Breakouts


Friday, January 11 | 8:00AM - 11:15AM
New Insights into the Pathogenesis of Lung Diseases
Room: Sweeney Ballroom C-E

Speaker 1 of 7
* Donata Vercelli, University of Arizona, USA

Friday, January 11 | 8:00AM - 11:15AM
New Insights into the Pathogenesis of Lung Diseases
Room: Sweeney Ballroom C-E

Speaker 2 of 7
Sally Wenzel-Morganroth, University of Pittsburgh, USA
Emerging Concepts on Asthma Heterogeneity

Friday, January 11 | 8:00AM - 11:15AM
New Insights into the Pathogenesis of Lung Diseases
Room: Sweeney Ballroom C-E

Speaker 3 of 7
Fernando D. Martinez, University of Arizona, USA
Early-Life Origins of Chronic Obstructive Pulmonary Disease

Friday, January 11 | 8:00AM - 11:15AM
New Insights into the Pathogenesis of Lung Diseases
Room: Sweeney Ballroom C-E

Speaker 4 of 7
Avrum Spira, Boston University, USA
Molecular Insights into COPD via Transcriptomic Profiling

Friday, January 11 | 8:00AM - 11:15AM
New Insights into the Pathogenesis of Lung Diseases
Room: Sweeney Ballroom C-E

Speaker 5 of 7
Ian M. Adcock, Imperial College London, UK
Epigenetic Regulation of Lung Disease

Friday, January 11 | 8:00AM - 11:15AM
New Insights into the Pathogenesis of Lung Diseases
Room: Sweeney Ballroom C-E

Speaker 6 of 7
Peter McErlean, Kings College London, UK
Short Talk: Asthma Exacerbations during Acute Respiratory Illness are Characterized by Distinct Expression Profiles of Immunoregulatory and Cellular Repair Genes in the Nasal Mucosa

Friday, January 11 | 8:00AM - 11:15AM
New Insights into the Pathogenesis of Lung Diseases
Room: Sweeney Ballroom C-E

Speaker 7 of 7
Gabriela Wlasiuk, University of Arizona, USA
Short Talk: Epigenetic Predictors of Childhood Asthma are Detectable in the Methylome at Birth

Friday, January 11 | 8:00AM - 11:00AM
Adaptations to Chronic Helminth Infection
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 1 of 8
* Judith E. Allen, University of Manchester, UK


Friday, January 11 | 8:00AM - 11:00AM
Adaptations to Chronic Helminth Infection
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 2 of 8
Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
Human Helminth Infections, Immune Responses and Inflammatory Diseases


Friday, January 11 | 8:00AM - 11:00AM
Adaptations to Chronic Helminth Infection
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 3 of 8
Ajay Chawla, Merck and University of California, San Francisco, USA
Metabolic (Regenerative) Consequences of Type 2 Immunity


Friday, January 11 | 8:00AM - 11:00AM
Adaptations to Chronic Helminth Infection
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 4 of 8
Andrew S. MacDonald, University of Manchester, UK
Short Talk: Epigenetic Control of Th2 Induction by Dendritic Cells


Friday, January 11 | 8:00AM - 11:00AM
Adaptations to Chronic Helminth Infection
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 5 of 8
Ilaria Mosconi, EPFL SV GHI UPHARRIS, Switzerland
Short Talk: Differential Role of Peyer’s Patches and Mesenteric Lymph Nodes during Helminth Infection


Friday, January 11 | 8:00AM - 11:00AM
Adaptations to Chronic Helminth Infection
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 6 of 8
Hermelijn H. Smits, Leiden University Center, Netherlands
Short Talk: Human Schistosome-Induced IL-10 Producing CD1dhi B Cells Regulate Effector T Cell Responses


Friday, January 11 | 8:00AM - 11:00AM
Adaptations to Chronic Helminth Infection
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 7 of 8
Mark A. Travis, University of Manchester, UK
Short Talk: The TGFbeta-Activating Integrin alphavbeta8 on Dendritic Cells Regulates Type 2 Immunity in the Intestine to Promote Chronic Parasitic Infection


Friday, January 11 | 8:00AM - 11:00AM
Adaptations to Chronic Helminth Infection
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 8 of 8
Barbara Platzer, Novartis Institutes for BioMedical Research, USA
Short Talk: Dendritic Cells use IgE as an Antigen Sensor for Regulating Th2 Immunity


Friday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakouts


Friday, January 11 | 11:15AM - 1:00PM
Poster Setup
Room: Sweeney F


Friday, January 11 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Friday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F


Friday, January 11 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F


Friday, January 11 | 5:00PM - 7:00PM
Infectious Origins of Lung Disease
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Jay K. Kolls, Tulane School of Medicin, USA

Friday, January 11 | 5:00PM - 7:00PM
Infectious Origins of Lung Disease
Room: Sweeney Ballroom C-E

Speaker 2 of 5
James E. Gern, University of Wisconsin, USA
Virus Infections and Asthma Inception and Exacerbation

Friday, January 11 | 5:00PM - 7:00PM
Infectious Origins of Lung Disease
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Sebastian L. Johnston, Imperial College London, UK
Mechanisms of Rhinovirus-Induced Exacerbations in Asthma and COPD

Friday, January 11 | 5:00PM - 7:00PM
Infectious Origins of Lung Disease
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Michael J. Holtzman, Washington University in St. Louis, USA
Epithelial-Immune Cell Collaboration for Chronic Airway Disease

Friday, January 11 | 5:00PM - 7:00PM
Infectious Origins of Lung Disease
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Derek E. Byers, Washington University, USA
Short Talk: Predominant Role of IL-33 as the Upstream Inducer of IL-13-Mediated Chronic Airway Disease

Friday, January 11 | 5:00PM - 7:00PM
Regulating the Type 2 Cytokines
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Thomas A. Wynn, Pfizer, USA


Friday, January 11 | 5:00PM - 7:00PM
Regulating the Type 2 Cytokines
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 2 of 5
Dirk E. Smith, Insight Bioconsulting, USA
The Role of IL-33 in Regulating Innate Airway Inflammation


Friday, January 11 | 5:00PM - 7:00PM
Regulating the Type 2 Cytokines
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 3 of 5
Steven F. Ziegler, Benaroya Research Institute, USA
TSLP in the Regulation of Type 2 Immunity


Friday, January 11 | 5:00PM - 7:00PM
Regulating the Type 2 Cytokines
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Richard M. Maizels, University of Glasgow, UK
Modulation of the Host Immune Response by Parasitic Helminths


Friday, January 11 | 5:00PM - 7:00PM
Regulating the Type 2 Cytokines
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 5 of 5
Toshinori Nakayama, Chiba University, Japan
Short Talk: Sox4 Acts as a Downstream Target of TGFbeta and Suppresses GATA3-Induced Th2 Cell Differentiation


Friday, January 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts


Friday, January 11 | 7:30PM - 10:00PM
Poster Session 1
Room: Sweeney F


Saturday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Main Level Breakouts


Saturday, January 12 | 7:30AM - 8:00AM
Poster Setup
Room: Sweeney F


Saturday, January 12 | 8:00AM - 5:00PM
Poster Viewing
Room: Sweeney F


Saturday, January 12 | 8:00AM - 11:00AM
Innate Helper Cells in Type 2 Immunity (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 6
* David Voehringer, University Hospital of Erlangen, Germany

Saturday, January 12 | 8:00AM - 11:00AM
Innate Helper Cells in Type 2 Immunity (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 6
Andrew N. J. McKenzie, MRC Laboratory of Molecular Biology, UK
IL-25 and IL-33 Regulation of ILC2 in Protective Immunity and Allergy

Saturday, January 12 | 8:00AM - 11:00AM
Innate Helper Cells in Type 2 Immunity (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 6
Hergen Spits, University of Amsterdam, Netherlands
The Spectrum of Human Innate Lymphoid Cells

Saturday, January 12 | 8:00AM - 11:00AM
Innate Helper Cells in Type 2 Immunity (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 6
Richard M. Locksley, HHMI/University of California, San Francisco, USA
Function-Marking the Cells of Allergic Immunity

Saturday, January 12 | 8:00AM - 11:00AM
Innate Helper Cells in Type 2 Immunity (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 6
Shigeo Koyasu, Keio University School of Medicine, Japan
Critical Role of GATA3 in the Differentiation and Function Natural Helper Cells, a Member of the Group 2 ILCs

Saturday, January 12 | 8:00AM - 11:00AM
Innate Helper Cells in Type 2 Immunity (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 6
Laurel Monticelli, Weill Cornell Medicine, USA
Short Talk: Innate Lymphoid Cells Promote Airway Epithelial Repair through the Amphiregulin-EGFR Pathway

Saturday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakouts


Saturday, January 12 | 11:00AM - 12:00PM
Lunch
Room: Sweeney F, Main Level Breakouts


Saturday, January 12 | 12:00PM - 2:30PM
Poster Session 2
Room: Sweeney F


Saturday, January 12 | 2:30PM - 4:30PM
Workshop 1: Molecular Regulation of Allergic Responses
Room: Sweeney Ballroom C-E

Speaker 1 of 8
* Clare M. Lloyd, Imperial College London, UK

Saturday, January 12 | 2:30PM - 4:30PM
Workshop 1: Molecular Regulation of Allergic Responses
Room: Sweeney Ballroom C-E

Speaker 2 of 8
Jennifer L. Ather, University of Vermont, USA
Serum Amyloid A Downregulates Bim Expression and Caspase-3 Activation in Serum-Starved Bone Marrow Derived Dendritic Cells and Induces Glucocorticoid Resistance in CD4+ T Cells

Saturday, January 12 | 2:30PM - 4:30PM
Workshop 1: Molecular Regulation of Allergic Responses
Room: Sweeney Ballroom C-E

Speaker 3 of 8
Sofia Tousa, Biomedical Research Foundation of the Academy of Athens, Greece
Activin-A-Induced Human Regulatory T Cells: Novel Controllers of Allergic Asthma

Saturday, January 12 | 2:30PM - 4:30PM
Workshop 1: Molecular Regulation of Allergic Responses
Room: Sweeney Ballroom C-E

Speaker 4 of 8
Elizabeth A. Jacobsen, Mayo Clinic, USA
Activated Pulmonary Eosinophils Are Necessary for Th2 Pulmonary Inflammation

Saturday, January 12 | 2:30PM - 4:30PM
Workshop 1: Molecular Regulation of Allergic Responses
Room: Sweeney Ballroom C-E

Speaker 5 of 8
Hiromasa Inoue, Kagoshima University, Japan
Role of Leukotriene B4 Receptor BLT2 in Allergic Airway Inflammation

Saturday, January 12 | 2:30PM - 4:30PM
Workshop 1: Molecular Regulation of Allergic Responses
Room: Sweeney Ballroom C-E

Speaker 6 of 8
Purvi Mehrotra, Indiana University School of Medicine, USA
PARP-14 and its Enzyme Activity Regulates Th2 Differentiation and Allergic Airway Disease

Saturday, January 12 | 2:30PM - 4:30PM
Workshop 1: Molecular Regulation of Allergic Responses
Room: Sweeney Ballroom C-E

Speaker 7 of 8
David J. Cousins, King's College London, UK
In vitro Differentiation and Transcriptome Profiling of Human Th9 Cells

Saturday, January 12 | 2:30PM - 4:30PM
Workshop 1: Molecular Regulation of Allergic Responses
Room: Sweeney Ballroom C-E

Speaker 8 of 8
Tao Liu, Brigham and Women’s Hospital, Harvard Medical School, USA
Deficiency of Inducible PGE2 is Sufficient to Cause Aspirin Sensitivity in the Setting of Pulmonary Inflammation

Saturday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F


Saturday, January 12 | 5:00PM - 7:00PM
Role of Th17 Cells in the Regulation of Lung Immunity
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Hergen Spits, University of Amsterdam, Netherlands

Saturday, January 12 | 5:00PM - 7:00PM
Role of Th17 Cells in the Regulation of Lung Immunity
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Jay K. Kolls, Tulane School of Medicin, USA
Th17 Cells in the Regulation of Lung Immunity

Saturday, January 12 | 5:00PM - 7:00PM
Role of Th17 Cells in the Regulation of Lung Immunity
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Susan V. Lynch, University of California, San Francisco, USA
Airway Microbiota and Lung Disease

Saturday, January 12 | 5:00PM - 7:00PM
Role of Th17 Cells in the Regulation of Lung Immunity
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA
Colonization with Segmented Filamentous Bacteria Drives Severe Asthma through an IL-17A-Dependent Mechanism

Saturday, January 12 | 5:00PM - 7:00PM
Role of Th17 Cells in the Regulation of Lung Immunity
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Saheli Chowdhury, Academic Medical Center, Netherlands
Short Talk: Exposure to IL-17 Reveals Defective mRNA Degradation by Bronchial Epithelial Cells in 70% of Patients with Asthma

Saturday, January 12 | 5:00PM - 7:15PM
Adaptive Th2 and TFH Cells
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 1 of 7
* Richard M. Locksley, HHMI/University of California, San Francisco, USA


Saturday, January 12 | 5:00PM - 7:15PM
Adaptive Th2 and TFH Cells
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 2 of 7
K. Mark Ansel, University of California San Francisco, USA
MicroRNA Regulation of TFH and Th2 Cell Development


Saturday, January 12 | 5:00PM - 7:15PM
Adaptive Th2 and TFH Cells
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 3 of 7
Shane Crotty, La Jolla Institute for Immunology, USA
The Relationship between Th2 and Tfh Cells: Defining Characteristics of Tfh Cell Differentiation and Function


Saturday, January 12 | 5:00PM - 7:15PM
Adaptive Th2 and TFH Cells
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 4 of 7
Matthew D. Taylor, University of Edinburgh, Scotland
Short Talk: Th2 Cell Intrinsic Hypo-Responsiveness Determines Susceptibility to Helminth Infection via the PD-1/PD-L2 Pathway


Saturday, January 12 | 5:00PM - 7:15PM
Adaptive Th2 and TFH Cells
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 5 of 7
Fabienne Andris, Université Libre de Bruxelles, Belgium
Short Talk: The Capacity of Th2 Lymphocytes to Deliver B Cell Help Requires Expression of the Transcription Factor STAT3


Saturday, January 12 | 5:00PM - 7:15PM
Adaptive Th2 and TFH Cells
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 6 of 7
Nicholas van Panhuys, NIAID, National Institutes of Health, USA
Short Talk: TCR Strength of Signal is Upstream of and Dominates Over Cytokine Effects in Controlling CD4+ T Cell Polarization in Vivo


Saturday, January 12 | 5:00PM - 7:15PM
Adaptive Th2 and TFH Cells
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 7 of 7
Christopher D. C. Allen, University of California, San Francisco, USA
Short Talk: Regulation of IgE+ B Cell Responses Revealed by Novel Fluorescent Reporter Mice


Sunday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Main Level Breakouts


Sunday, January 13 | 8:00AM - 11:15AM
Lung Development, Repair and Remodeling
Room: Sweeney Ballroom C-E

Speaker 1 of 7
* Fernando D. Martinez, University of Arizona, USA

Sunday, January 13 | 8:00AM - 11:15AM
Lung Development, Repair and Remodeling
Room: Sweeney Ballroom C-E

Speaker 2 of 7
Jeffrey A. Whitsett, Cincinnati Children's Hospital Medical Center, USA
Epigenetic and Genetic Regulation of Goblet Cell Metaplasia and Antiviral Innate Immunity by FOXA3

Sunday, January 13 | 8:00AM - 11:15AM
Lung Development, Repair and Remodeling
Room: Sweeney Ballroom C-E

Speaker 3 of 7
Paul W. Noble, Cedars-Sinai Medical Center, USA
Matrix Regulation of Lung Injury, Inflammation and Repair

Sunday, January 13 | 8:00AM - 11:15AM
Lung Development, Repair and Remodeling
Room: Sweeney Ballroom C-E

Speaker 4 of 7
Stephanie C. Eisenbarth, Yale University, USA
NOD-Like Receptors and the Regulation of Lung Inflammation

Sunday, January 13 | 8:00AM - 11:15AM
Lung Development, Repair and Remodeling
Room: Sweeney Ballroom C-E

Speaker 5 of 7
Joanne L. Wright, University of British Columbia, Canada
Cigarette Smoke Induced COPD - Use of Animal Models

Sunday, January 13 | 8:00AM - 11:15AM
Lung Development, Repair and Remodeling
Room: Sweeney Ballroom C-E

Speaker 6 of 7
Hesam Movassagh, University of Manitoba, Canada
Short Talk: Semaphorin 3E Inhibits Human Airway Smooth Muscle Cell Proliferation and Migration

Sunday, January 13 | 8:00AM - 11:15AM
Lung Development, Repair and Remodeling
Room: Sweeney Ballroom C-E

Speaker 7 of 7
Sejal Saglani, Imperial College London, UK
Short Talk: Interleukin-33 Promotes Airway Remodelling in Paediatric Severe Steroid Resistant Asthma

Sunday, January 13 | 8:00AM - 11:15AM
Commensals, Immunity and Epithelial Homeostasis
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 1 of 7
* Hajime Karasuyama, Tokyo Medical and Dental University, Graduate School, Japan


Sunday, January 13 | 8:00AM - 11:15AM
Commensals, Immunity and Epithelial Homeostasis
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 2 of 7
Wenjun Ouyang, Amgen, Inc., USA
Regulation and Function of IL-22 on Epithelial Cells


Sunday, January 13 | 8:00AM - 11:15AM
Commensals, Immunity and Epithelial Homeostasis
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 3 of 7
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Commensal-Pathogen Interactions in Skin Immunity


Sunday, January 13 | 8:00AM - 11:15AM
Commensals, Immunity and Epithelial Homeostasis
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 4 of 7
Sabine Eming, University of Cologne, Germany
Tissue Repair and Type 2 Immunity


Sunday, January 13 | 8:00AM - 11:15AM
Commensals, Immunity and Epithelial Homeostasis
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 5 of 7
De' Broski R. Herbert, University of Pennsylvania, USA
Short Talk: Trefoil Factor 2 Initiates IL-33 Production for Non-Canonical Type 2 Immunity against Murine Hookworm Infection


Sunday, January 13 | 8:00AM - 11:15AM
Commensals, Immunity and Epithelial Homeostasis
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 6 of 7
Soichiro Yoshikawa, Tokyo Medical and Dental University, Japan
Short Talk: Mechanisms Underlying the Recruitment, Accumulation and Activation of Basophils at Tick-Feeding Sites for Protective Immunity to Tick Re-Infestation


Sunday, January 13 | 8:00AM - 11:15AM
Commensals, Immunity and Epithelial Homeostasis
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 7 of 7
P'ng Loke, NYU School of Medicine, USA
Short Talk: Type 2 Immunity in Helminth Treatment for Inflammatory Bowel Diseases


Sunday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakouts


Sunday, January 13 | 11:15AM - 1:00PM
Poster Setup
Room: Sweeney F


Sunday, January 13 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Sunday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F


Sunday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F


Sunday, January 13 | 5:00PM - 7:00PM
Mechanisms of Chronic Obstructive Pulmonary Disease
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Sebastian L. Johnston, Imperial College London, UK

Sunday, January 13 | 5:00PM - 7:00PM
Mechanisms of Chronic Obstructive Pulmonary Disease
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Shyam Biswal, Johns Hopkins University, USA
Oxidative Stress Regulation of Lung Inflammation in COPD

Sunday, January 13 | 5:00PM - 7:00PM
Mechanisms of Chronic Obstructive Pulmonary Disease
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Augustine Choi, Harvard Medical School, USA
Regulation and Function of Autophagy in COPD

Sunday, January 13 | 5:00PM - 7:00PM
Mechanisms of Chronic Obstructive Pulmonary Disease
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Farrah Kheradmand, Baylor College of Medicine, USA
Autoreactive T Cells in The Pathophysiology of Human and Mouse Emphysema

Sunday, January 13 | 5:00PM - 7:00PM
Mechanisms of Chronic Obstructive Pulmonary Disease
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Chandran Nagaraj, Ludwig Boltzmann Institute for Lung Vascular Research, Austria
Short Talk: p22phox Regulates House Dust Mite (HDM) Induced Allergic Airway Inflammation

Sunday, January 13 | 5:00PM - 7:00PM
Myeloid Cells in Tissue Homeostasis
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Richard M. Maizels, University of Glasgow, UK


Sunday, January 13 | 5:00PM - 7:00PM
Myeloid Cells in Tissue Homeostasis
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 2 of 5
Judith E. Allen, University of Manchester, UK
Macrophages in Helminth Infection: Where Inflammation is Anti-Inflammatory


Sunday, January 13 | 5:00PM - 7:00PM
Myeloid Cells in Tissue Homeostasis
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 3 of 5
David Voehringer, University Hospital of Erlangen, Germany
Eosinophil and Basophil Responses to Allergens and Helminths


Sunday, January 13 | 5:00PM - 7:00PM
Myeloid Cells in Tissue Homeostasis
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Hajime Karasuyama, Tokyo Medical and Dental University, Graduate School, Japan
Basophil as a Crucial Player in Acquired Immune Responses


Sunday, January 13 | 5:00PM - 7:00PM
Myeloid Cells in Tissue Homeostasis
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 5 of 5
Carla V. Rothlin, Yale University, USA
Short Talk: TAMing Type 2 Immunity


Sunday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts


Sunday, January 13 | 7:30PM - 10:00PM
Poster Session 3
Room: Sweeney F


Monday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Main Level Breakouts


Monday, January 14 | 8:00AM - 11:00AM
Initiating Type 2 Immunity (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 6
* Andrew N. J. McKenzie, MRC Laboratory of Molecular Biology, UK

Monday, January 14 | 8:00AM - 11:00AM
Initiating Type 2 Immunity (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 6
Jean-Philippe Girard, Institute of Pharmacology and Structural Biology, France
IL-33 Processing and Activation by Inflammatory Proteases

Monday, January 14 | 8:00AM - 11:00AM
Initiating Type 2 Immunity (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 6
Marco Idzko, University Hospital Freiburg, Germany
ATP and P2X Receptors in Type 2 Immunity

Monday, January 14 | 8:00AM - 11:00AM
Initiating Type 2 Immunity (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 6
Jack A. Elias, Yale School of Medicine, USA
Chitinase-like Moieties in Lung Inflammation, Injury and Repair

Monday, January 14 | 8:00AM - 11:00AM
Initiating Type 2 Immunity (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 6
Laura J. Simpson, Stanford University, USA
Short Talk: miRNA Expression in CD4 T Cells from Asthmatic Airways

Monday, January 14 | 8:00AM - 11:00AM
Initiating Type 2 Immunity (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 6
Takehiko Shibata, University of Michigan Medical School, USA
Short Talk: Gas6/TAM Signaling Differentially Modulates Chronic Fungal Asthma with the Expansion of Myeloid Regulatory Cell Subsets in Mice

Monday, January 14 | 9:00AM - 9:20AM
Coffee Break
Room: Sweeney F, Main Level Breakouts


Monday, January 14 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Viral Infections and Exacerbations of Lung Disea
se
Room: Sweeney Ballroom C-E

Speaker 1 of 7
* Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Viral Infections and Exacerbations of Lung Disea
se
Room: Sweeney Ballroom C-E

Speaker 2 of 7
Charles S. Dela Cruz, Yale University, USA
Cigarette Smoke Exposure Enhances Interleukin-15, NK and CD8 T Cell Responses during Influenza Virus Infection in Models of COPD

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Viral Infections and Exacerbations of Lung Disea
se
Room: Sweeney Ballroom C-E

Speaker 3 of 7
Sumit Ghosh, North Dakota State University, USA
Hyaluronic Acid Impacts B Lymphocyte Recruitment and Function in a Murine Fungal Allergic Asthma Model

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Viral Infections and Exacerbations of Lung Disea
se
Room: Sweeney Ballroom C-E

Speaker 4 of 7
Amali E. Samarasinghe, University of Tennessee Health Science Center, USA
Allergic Eosinophils Enhance Anti-Viral Defenses in a Murine Co-Morbidity Model of Asthma and Influenza

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Viral Infections and Exacerbations of Lung Disea
se
Room: Sweeney Ballroom C-E

Speaker 5 of 7
Tamlyn Peel, Imperial College London, UK
IL-17 Modulation of Rhinovirus-Induced Allergic Airways Disease

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Viral Infections and Exacerbations of Lung Disea
se
Room: Sweeney Ballroom C-E

Speaker 6 of 7
Lara Ravanetti, Academic Medical Center, Netherlands
Influenza-Induced Exacerbation in a Murine Chronic House Dust Mite (HDM) Asthma Model

Monday, January 14 | 2:30PM - 4:30PM
Workshop 2: Viral Infections and Exacerbations of Lung Disea
se
Room: Sweeney Ballroom C-E

Speaker 7 of 7
Kristen N. Kindrachuk, National Institutes of Health, USA
Muc5ac-Deficiency Exacerbates Bleomycin-Induced Airway Inflammation

Monday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F


Monday, January 14 | 5:00PM - 7:00PM
Therapeutic Opportunities in Asthma and COPD
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Sally Wenzel-Morganroth, University of Pittsburgh, USA

Monday, January 14 | 5:00PM - 7:00PM
Therapeutic Opportunities in Asthma and COPD
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Aili Lazaar, GlaxoSmithKline, USA
Challenges and Opportunities in COPD Drug Development

Monday, January 14 | 5:00PM - 7:00PM
Therapeutic Opportunities in Asthma and COPD
Room: Sweeney Ballroom C-E

Speaker 3 of 5
John G. Matthews, Genentech, Inc., USA
Treatment of Adult Asthmatics with the Anti-IL-13 Lebrikizumab

Monday, January 14 | 5:00PM - 7:00PM
Therapeutic Opportunities in Asthma and COPD
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Alison L. Budelsky, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
Blockade of IL-17RA in Asthma

Monday, January 14 | 5:00PM - 7:00PM
Therapeutic Opportunities in Asthma and COPD
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Sofie Lock Johansson, Institut for Molecular Medicine, Denmark
Short Talk: Microfibril Associated Protein 4 (MFAP4) Is Associated to Dyspnea and the Composite BODE Index in COPD

Monday, January 14 | 5:00PM - 7:15PM
Pathologic Syndromes
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 1 of 6
* Yasmine Belkaid, NIAID, National Institutes of Health, USA


Monday, January 14 | 5:00PM - 7:15PM
Pathologic Syndromes
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 2 of 6
Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Lymphocyte Defects in Hyper-IgE Syndromes


Monday, January 14 | 5:00PM - 7:15PM
Pathologic Syndromes
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 3 of 6
Thomas A. Wynn, Pfizer, USA
Macrophages and Mucins in the Pathogenesis of Type 2 Immunity


Monday, January 14 | 5:00PM - 7:15PM
Pathologic Syndromes
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 4 of 6
Lawren C. Wu, Amgen Inc., USA
Therapeutic Targeting of IgE-Switched Cells in Asthma


Monday, January 14 | 5:00PM - 7:15PM
Pathologic Syndromes
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 5 of 6
Mark S. Wilson, Genentech, Inc., USA
Short Talk: miR-182 and miR-10a Are Key Regulators of Treg Specialisation and Stability during Th2 and Th1-Associated Inflammation


Monday, January 14 | 5:00PM - 7:15PM
Pathologic Syndromes
This session is from Type 2 Immunity
Room: Sweeney Ballroom A-B

Speaker 6 of 6
Adam Matson, University of Connecticut Health Center, USA
Short Talk: Maternal Allergy Is Associated with Surface-Bound IgE on Cord Blood Basophils


Monday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts


Monday, January 14 | 8:00PM - 11:00PM
Entertainment
Room: Sweeney F, Main Level Breakouts


Monday, January 14 | 8:00PM - 11:00PM
Cash Bar
Room: Sweeney F, Main Level Breakouts


Tuesday, January 15 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.