Web Desc
Diabetes - New Insights into Mechanism of Disease and its Treatment
joint with Adipose Tissue Biology
Organizer(s): C. Ronald Kahn, Jens C. Brüning and Gerald I. Shulman
Date: January 27 - February 01, 2013
Location: Keystone Resort, Keystone, CO, USA
Sponsored by EMD Millipore, MedImmune and Nestlé Institute of Health Sciences
Summary of Meeting:
We are in the midst of an epidemic of type 2 diabetes and the closely related metabolic syndrome. These disorders come from a complete interaction between genes and environment which is not fully understood. The goals of this meeting are to address important new areas of research into the primary pathogenesis of these disorders and especially focus on those that might lead to new therapies. The major topics of the meeting are: 1) Mechanisms of metabolic dysfunction and new therapeutic targets for diabetes and obesity; 2) miRNAs in control of metabolism; 3) Aging, mitochondria, and control of metabolism; 4) Epigenetics and perinatal imprinting in diabetes and obesity; 5) CNS control of metabolism; 6) Gastric bypass surgery and the gut in control of metabolism; 7) Metabolic mediators of insulin resistance; and 8) Signaling defects and inflammation in insulin resistance. The major goals of this meeting are to: 1) Make investigators of aware of important new advances in the field of diabetes research; 2) Bring new topics of research from outside the field to the diabetes research community; 3) Stimulate interactions and potential collaborations between participants; and 4) Bring lessons from clinical practice back to the bench. The program should bring new scientific knowledge, new methods and new insights from clinical practice together to stimulate interchange of ideas and even collaborations. Although this meeting has been a regular annual event in the Keystone Symposia series, many of the topics and speakers are new and thus will enrich the field in new ways. The Keystone Symposia Diabetes meeting remains the most important forum for new basic science presentations in the field of diabetes. By bringing it together with the conference on Adipocyte Biology and having multiple joint sessions, this meeting fill a need in the scientific community that is not filled by other conferences. The meeting has novel content that will inform and challenge the attendees and brings many new research paradigms, as well as novel approaches and methods to the scientific community. The meeting is truly interdisciplinary, with not only basic scientists and clinical scientists, but those from many disciplines outside the fields of endocrinology and metabolism, including gastroenterology, neuroscience, innate immunity and genetics.
Scholarship Deadline: September 27 2012
Discounted Abstract Deadline: September 27 2012
Abstract Deadline: October 29 2012
Discounted Registration Deadline: November 28 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
EMD MilliporeMedImmuneNestlé Institute of Health Sciences
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.
Journal of Lipid Research
Educational grant from Lilly USA, LLC
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-04
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 27 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Monday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Monday, January 28 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 1 of 3
* Susan K. Fried, Icahn School of Medicine at Mount Sinai, USA

Monday, January 28 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 2 of 3
* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

Monday, January 28 | 8:00AM - 9:00AM
Welcome and Keynote Address (Joint)
Room: Columbine Ballroom

Speaker 3 of 3
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Metabolic Regulation in Cancer Biology

Monday, January 28 | 9:00AM - 11:00AM
Mechanisms of Metabolic Dysfunction and New Therapeutic Targ
ets for Diabetes and Obesity (Joint)

Room: Columbine Ballroom

Speaker 1 of 5
* David E. Kelley, Merck & Co., Inc., USA

Monday, January 28 | 9:00AM - 11:00AM
Mechanisms of Metabolic Dysfunction and New Therapeutic Targ
ets for Diabetes and Obesity (Joint)

Room: Columbine Ballroom

Speaker 2 of 5
* David E. Moller, Eli Lilly and Company, USA

Monday, January 28 | 9:00AM - 11:00AM
Mechanisms of Metabolic Dysfunction and New Therapeutic Targ
ets for Diabetes and Obesity (Joint)

Room: Columbine Ballroom

Speaker 3 of 5
Bruce M. Spiegelman, Harvard Medical School, USA
Control of Beige Fat Thermogenesis: Toward a New Generation of Therapeutics

Monday, January 28 | 9:00AM - 11:00AM
Mechanisms of Metabolic Dysfunction and New Therapeutic Targ
ets for Diabetes and Obesity (Joint)

Room: Columbine Ballroom

Speaker 4 of 5
David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Journal of Lipid Research Lectureship Award Presented by Kathryn Moore: Regulation of Nutrient Metabolism by FGF21

Monday, January 28 | 9:00AM - 11:00AM
Mechanisms of Metabolic Dysfunction and New Therapeutic Targ
ets for Diabetes and Obesity (Joint)

Room: Columbine Ballroom

Speaker 5 of 5
Philippe Froguel, Imperial College of London, UK
Germline and Somatic Clonal Genomic Structure Events in Diabetes and Obesity and their Relation with Associated Diseases

Monday, January 28 | 9:40AM - 10:00AM
Coffee Break
Room: Longs Peak Foyer


Monday, January 28 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Monday, January 28 | 11:00AM - 12:00PM
APSA Panel on Career Development (Joint)
Room: Columbine Ballroom

Speaker 1 of 6
* Jennifer M. Kwan, University of Illinois, Chicago, USA

Monday, January 28 | 11:00AM - 12:00PM
APSA Panel on Career Development (Joint)
Room: Columbine Ballroom

Speaker 2 of 6
* Laina King, Keystone Symposia, USA

Monday, January 28 | 11:00AM - 12:00PM
APSA Panel on Career Development (Joint)
Room: Columbine Ballroom

Speaker 3 of 6
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

Monday, January 28 | 11:00AM - 12:00PM
APSA Panel on Career Development (Joint)
Room: Columbine Ballroom

Speaker 4 of 6
David E. Kelley, Merck & Co., Inc., USA

Monday, January 28 | 11:00AM - 12:00PM
APSA Panel on Career Development (Joint)
Room: Columbine Ballroom

Speaker 5 of 6
Anne C. Ferguson-Smith, University of Cambridge, UK

Monday, January 28 | 11:00AM - 12:00PM
APSA Panel on Career Development (Joint)
Room: Columbine Ballroom

Speaker 6 of 6
Randy S. Levinson, Cell Press, USA

Monday, January 28 | 11:00AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Monday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: New Aspects of Insulin Signaling and Insulin Res
istance
Room: Longs/Grays Peaks

Speaker 1 of 9
* Domenico Accili, Columbia University, USA

Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: New Aspects of Insulin Signaling and Insulin Res
istance
Room: Longs/Grays Peaks

Speaker 2 of 9
Utpal B. Pajvani, Columbia University Medical Center, USA
Inhibition of Notch Uncouples Akt Activation from Hepatic Lipid Accumulation by Decreasing mTorc1 Stability

Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: New Aspects of Insulin Signaling and Insulin Res
istance
Room: Longs/Grays Peaks

Speaker 3 of 9
Rebecca A. Haeusler, Columbia University, USA
FoxOs Regulate Liver Metabolic Fluxes

Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: New Aspects of Insulin Signaling and Insulin Res
istance
Room: Longs/Grays Peaks

Speaker 4 of 9
Ana Paula Arruda, Harvard School of Public Health, USA
Altered Mitochondria-Associated ER Membranes (MAMs) Links ER Stress to Mitochondrial Dysfunction in Obesity

Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: New Aspects of Insulin Signaling and Insulin Res
istance
Room: Longs/Grays Peaks

Speaker 5 of 9
Mads Fuglsang Kjolby, Aarhus University, Denmark
The Ectodomain of SorCS1 Increases Peripheral Insulin Sensitivity and Lowers Plasma Glucose Levels in Mice

Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: New Aspects of Insulin Signaling and Insulin Res
istance
Room: Longs/Grays Peaks

Speaker 6 of 9
Jeremie Boucher, AstraZeneca, Sweden
A Novel Role for Insulin and IGF-1 Receptors in Control of Genomic Imprinting

Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: New Aspects of Insulin Signaling and Insulin Res
istance
Room: Longs/Grays Peaks

Speaker 7 of 9
Yingfeng Deng, University of Texas Southwestern Medical Center, USA
Revisiting the Leloir Pathway: A Novel Connection between ER Stress and Insulin Sensitivity

Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: New Aspects of Insulin Signaling and Insulin Res
istance
Room: Longs/Grays Peaks

Speaker 8 of 9
Esther Phielix, Maastricht UMC+, Netherlands
Reduction of Free Fatty Acids Lowers H2O2 Production But Does Not Restore Insulin-Stimulated Oxidative Capacity in Type 2 Diabetes

Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: New Aspects of Insulin Signaling and Insulin Res
istance
Room: Longs/Grays Peaks

Speaker 9 of 9
Darcy L. Johannsen, Pennington Biomedical Research Center, USA
Insulin Resistance Driven by High-Fat Overfeeding Is Not Mediated by Muscular Lipid Accumulation

Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: 8 Shades of Brown
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 1 of 10
* Jan Nedergaard, Stockholm University, Sweden


Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: 8 Shades of Brown
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 2 of 10
* Sheila Collins, Vanderbilt University Medical Center, USA


Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: 8 Shades of Brown
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 3 of 10
* Barbara Cannon, Stockholm University, Sweden
Introduction and Overview


Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: 8 Shades of Brown
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 4 of 10
Nicholas Douris, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
FGF21 Stimulates Browning of White Adipose Tissue via Direct Action on the Brain


Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: 8 Shades of Brown
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 5 of 10
Shingo Kajimura, Harvard Medical School, Beth Israel Deaconess Medical Center, USA
Molecular Control of Brown Adipose Cell Fate and Energy Homeostasis through a PRDM16 Transcriptional Complex


Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: 8 Shades of Brown
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 6 of 10
Therese J. Larsen, Rigshospitalet, University of Copenhagen, Denmark
Adipose Tissue from Supraclavicular Region of Adult Humans Display Classical Brown Fat Signature


Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: 8 Shades of Brown
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 7 of 10
Annie Moisan, Roche Pharmaceuticals, Switzerland
A Screening Platform to Identify Regulators of Human Adipocyte Cell Fate


Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: 8 Shades of Brown
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 8 of 10
Kathleen Ogilvie, aTyr Pharma, USA
Do Adipocyte Cell Lines Reliably Respond to Pharmacological Agents which Recruit a Beige-Cell Gene Signature in Vivo?


Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: 8 Shades of Brown
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 9 of 10
Hai-Bin Ruan, University of Minnesota, USA
Nutrient-Sensitive O-GlcNAc Signaling in AgRP Neurons Regulates Adipocyte Browning and Energy Homeostasis


Monday, January 28 | 2:30PM - 4:30PM
Workshop 1: 8 Shades of Brown
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 10 of 10
Courtney M. Anderson, University of California, Berkeley, USA
Requirement of the Scavenger Receptor CD36 for Brown Adipose Tissue Mitochondrial Function


Monday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 28 | 5:00PM - 7:00PM
miRNAs and Metabolic Disease
Room: Longs/Grays Peaks

Speaker 1 of 5
* Silvia Corvera, University of Massachusetts Medical School, USA

Monday, January 28 | 5:00PM - 7:00PM
miRNAs and Metabolic Disease
Room: Longs/Grays Peaks

Speaker 2 of 5
Markus Stoffel, ETH Zürich, Switzerland
miRNAs in Control of beta-Cell Function

Monday, January 28 | 5:00PM - 7:00PM
miRNAs and Metabolic Disease
Room: Longs/Grays Peaks

Speaker 3 of 5
Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
miRNAs in Control of Liver Metabolism

Monday, January 28 | 5:00PM - 7:00PM
miRNAs and Metabolic Disease
Room: Longs/Grays Peaks

Speaker 4 of 5
Anna Krook, Karolinska Institutet, Sweden
Role of miRNA Let7 in Diabetes-Related Inflammation

Monday, January 28 | 5:00PM - 7:00PM
miRNAs and Metabolic Disease
Room: Longs/Grays Peaks

Speaker 5 of 5
Thaís Amaral e Sousa, University of São Paulo, Brazil
Short Talk: Deregulation of microRNAs Let-7b and miR-696 in Mice Insulin Resistant Skeletal Muscle

Monday, January 28 | 5:00PM - 7:00PM
Losing Fat: Dynamics of Adipocyte Lipid Turnover
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 1 of 5
* Susan K. Fried, Icahn School of Medicine at Mount Sinai, USA


Monday, January 28 | 5:00PM - 7:00PM
Losing Fat: Dynamics of Adipocyte Lipid Turnover
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 2 of 5
Rudolf Zechner, University of Graz, Austria
Lipolysis: A Drug Target for Metabolic Disease?


Monday, January 28 | 5:00PM - 7:00PM
Losing Fat: Dynamics of Adipocyte Lipid Turnover
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 3 of 5
Paul F. Pilch, Boston University School of Medicine, USA
Consequences of Cav(e)lin/Caveolae Deficiency on Lipid Metabolism


Monday, January 28 | 5:00PM - 7:00PM
Losing Fat: Dynamics of Adipocyte Lipid Turnover
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 4 of 5
Richard N. Bergman, Cedars-Sinai Medical Center, USA
Role of Free Fatty Acids in the Insulin Resistance Syndrome


Monday, January 28 | 5:00PM - 7:00PM
Losing Fat: Dynamics of Adipocyte Lipid Turnover
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 5 of 5
Irfan J. Lodhi, Washington University School of Medicine, USA
Short Talk: Peroxisomal Lipid Synthesis Programs Adipose Tissue Development through PPAR Signaling


Monday, January 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom


Monday, January 28 | 7:30PM - 10:00PM
Poster Session 1
Room: Colorado Rockies Ballroom


Tuesday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Tuesday, January 29 | 8:00AM - 11:00AM
Aging, Mitochondria and Control of Metabolism
Room: Longs/Grays Peaks

Speaker 1 of 6
* Gerald I. Shulman, Yale University School of Medicine, USA

Tuesday, January 29 | 8:00AM - 11:00AM
Aging, Mitochondria and Control of Metabolism
Room: Longs/Grays Peaks

Speaker 2 of 6
Andrew G. Dillin, University of California, Berkeley, USA
Humoral Control of Mitochondrial Form and Function

Tuesday, January 29 | 8:00AM - 11:00AM
Aging, Mitochondria and Control of Metabolism
Room: Longs/Grays Peaks

Speaker 3 of 6
Kitt F. Petersen, Yale University School of Medicine, USA
Mitochondrial Function in Humans and its Relationship with Ectopic Lipid,
Insulin Resistance and the Metabolic Syndrome


Tuesday, January 29 | 8:00AM - 11:00AM
Aging, Mitochondria and Control of Metabolism
Room: Longs/Grays Peaks

Speaker 4 of 6
Eric M. Verdin, Buck Institute for Research on Aging, USA
Reversible Acetylation in Regulation of Mitochondrial Function and Aging

Tuesday, January 29 | 8:00AM - 11:00AM
Aging, Mitochondria and Control of Metabolism
Room: Longs/Grays Peaks

Speaker 5 of 6
Domenico Accili, Columbia University, USA
Foxo2013: Can we Leverage some of its Properties to Treat Type 2 Diabetes

Tuesday, January 29 | 8:00AM - 11:00AM
Aging, Mitochondria and Control of Metabolism
Room: Longs/Grays Peaks

Speaker 6 of 6
Dudley W. Lamming, Whitehead Institute for Biomedical Research, USA
Short Talk: Depletion of mTORC2 Impairs the Health and Longevity of Mice Independently of Effects on Hepatic Glucose Output

Tuesday, January 29 | 8:00AM - 11:00AM
Remodeling a Healthy Adipose Tissue
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 1 of 7
* Stephen R. Farmer, Boston University School of Medicine, USA


Tuesday, January 29 | 8:00AM - 11:00AM
Remodeling a Healthy Adipose Tissue
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 2 of 7
Silvia Corvera, University of Massachusetts Medical School, USA
Metabolic Control of Adipose Tissue Angiogenesis


Tuesday, January 29 | 8:00AM - 11:00AM
Remodeling a Healthy Adipose Tissue
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 3 of 7
Rajat Singh, Albert Einstein College of Medicine, USA
Autophagy and Lipid Metabolism


Tuesday, January 29 | 8:00AM - 11:00AM
Remodeling a Healthy Adipose Tissue
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 4 of 7
Chad A. Cowan, Beth Israel Deaconess Medical Center, USA
Genome Editing to Generate Human Cellular Models of Metabolic Disease


Tuesday, January 29 | 8:00AM - 11:00AM
Remodeling a Healthy Adipose Tissue
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 5 of 7
Yun-Hee Lee, Seoul National University, South Korea
Short Talk: Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration


Tuesday, January 29 | 8:00AM - 11:00AM
Remodeling a Healthy Adipose Tissue
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 6 of 7
Carolyn S. Hudak, Harvard University, USA
Short Talk: Pref-1 Expressing Cells are the Adipose Precursors


Tuesday, January 29 | 8:00AM - 11:00AM
Remodeling a Healthy Adipose Tissue
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 7 of 7
Li Qiang, Columbia University Medical Center, USA
Short Talk: Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of PPARgamma


Tuesday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, January 29 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Tuesday, January 29 | 11:00AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Tuesday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Tuesday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 29 | 5:00PM - 7:00PM
Epigenetics and Perinatal Imprinting in Diabetes and Obesity
(Joint)

Room: Columbine Ballroom

Speaker 1 of 4
* Philippe Froguel, Imperial College of London, UK

Tuesday, January 29 | 5:00PM - 7:00PM
Epigenetics and Perinatal Imprinting in Diabetes and Obesity
(Joint)

Room: Columbine Ballroom

Speaker 2 of 4
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Diabetes and Obesity - Nature or Nurture

Tuesday, January 29 | 5:00PM - 7:00PM
Epigenetics and Perinatal Imprinting in Diabetes and Obesity
(Joint)

Room: Columbine Ballroom

Speaker 3 of 4
Anne C. Ferguson-Smith, University of Cambridge, UK
Intergenerational Epigenetic Programming of Metabolic Defects in a Mouse Model of Undernutrition

Tuesday, January 29 | 5:00PM - 7:00PM
Epigenetics and Perinatal Imprinting in Diabetes and Obesity
(Joint)

Room: Columbine Ballroom

Speaker 4 of 4
Paolo Sassone-Corsi, University of California, Irvine, USA
Joining the Dots: Epigenetics, Metabolism and the Circadian Clock

Tuesday, January 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom


Tuesday, January 29 | 7:30PM - 10:00PM
Poster Session 2
Room: Colorado Rockies Ballroom


Wednesday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Wednesday, January 30 | 8:00AM - 11:00AM
Signaling Defects and Inflammation in Insulin Resistance (Jo
int)

Room: Columbine Ballroom

Speaker 1 of 6
* Gökhan S. Hotamisligil, Harvard School of Public Health, USA

Wednesday, January 30 | 8:00AM - 11:00AM
Signaling Defects and Inflammation in Insulin Resistance (Jo
int)

Room: Columbine Ballroom

Speaker 2 of 6
Diane Mathis, Harvard Medical School, USA
Regulatory T Cells Residing in Adipose Tissue

Wednesday, January 30 | 8:00AM - 11:00AM
Signaling Defects and Inflammation in Insulin Resistance (Jo
int)

Room: Columbine Ballroom

Speaker 3 of 6
Anthony W. Ferrante, Columbia University, USA
Non-Inflammatory Functions of Adipose Tissue Macrophages

Wednesday, January 30 | 8:00AM - 11:00AM
Signaling Defects and Inflammation in Insulin Resistance (Jo
int)

Room: Columbine Ballroom

Speaker 4 of 6
Alan R. Saltiel, University of California, San Diego, USA
Inflammatory Links between Obesity, Diabetes and Energy Expenditure

Wednesday, January 30 | 8:00AM - 11:00AM
Signaling Defects and Inflammation in Insulin Resistance (Jo
int)

Room: Columbine Ballroom

Speaker 5 of 6
Ajay Chawla, Merck Research Labs, USA
Innate Control of Metabolism

Wednesday, January 30 | 8:00AM - 11:00AM
Signaling Defects and Inflammation in Insulin Resistance (Jo
int)

Room: Columbine Ballroom

Speaker 6 of 6
Jan Mauer, Max Planck Institute for Neurological Research, Germany
Short Talk: IL-6 Signaling in Myeloid Cells Limits Obesity-Induced Insulin Resistance

Wednesday, January 30 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, January 30 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, January 30 | 11:00AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Wednesday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Wednesday, January 30 | 2:30PM - 3:30PM
Workshop 2A: Islet Pathophysiology
Room: Longs/Grays Peaks

Speaker 1 of 5
* Markus Stoffel, ETH Zürich, Switzerland

Wednesday, January 30 | 2:30PM - 3:30PM
Workshop 2A: Islet Pathophysiology
Room: Longs/Grays Peaks

Speaker 2 of 5
Nicole Ehrhardt, Cedars-Sinai Medical Center, USA
Lipase Maturation Factor 1 (LMF1): A New Player in ER-Stress and beta Cell Function

Wednesday, January 30 | 2:30PM - 3:30PM
Workshop 2A: Islet Pathophysiology
Room: Longs/Grays Peaks

Speaker 3 of 5
Yun Sok Lee, University of California, San Diego, USA
A Novel Pathway for Regulation of Insulin Secretion by Fractalkine and CX3CR1 System

Wednesday, January 30 | 2:30PM - 3:30PM
Workshop 2A: Islet Pathophysiology
Room: Longs/Grays Peaks

Speaker 4 of 5
Jean-Sébastien Annicotte, EGID CNRS UMR 8199, France
The P300/CBP-Associated Factor (PCAF) Is a Histone Acetyl Transferase that Controls beta-Cell Function

Wednesday, January 30 | 2:30PM - 3:30PM
Workshop 2A: Islet Pathophysiology
Room: Longs/Grays Peaks

Speaker 5 of 5
Veronika Leiss, University Tübingen, Germany
Role of Islet Galphai2 in the Regulation of Glucose Homeostasis

Wednesday, January 30 | 3:30PM - 4:30PM
Workshop 2B: New Drugs for Diabetes
Room: Longs/Grays Peaks

Speaker 1 of 5
* Hans Ulrich Stilz, Novo Nordisk A/S, Denmark

Wednesday, January 30 | 3:30PM - 4:30PM
Workshop 2B: New Drugs for Diabetes
Room: Longs/Grays Peaks

Speaker 2 of 5
Annelie Falkevall, Karolinska Institutet, Sweden
Targeting VEGF-B as a Novel Treatment for Insulin Resistance and Type 2 Diabetes

Wednesday, January 30 | 3:30PM - 4:30PM
Workshop 2B: New Drugs for Diabetes
Room: Longs/Grays Peaks

Speaker 3 of 5
James D. Dunbar, Eli Lilly & Company, USA
Comparison of the in vitro and in vivo Actions of FGF19 and FGF21

Wednesday, January 30 | 3:30PM - 4:30PM
Workshop 2B: New Drugs for Diabetes
Room: Longs/Grays Peaks

Speaker 4 of 5
Derek M. Erion, Takeda, USA
Hepato-Selective Glucokinase Activators Reduce Fasting and Postprandial Hyperglycemia in Rats without Inducing Hypoglycemia or Increasing Hepatic Lipids

Wednesday, January 30 | 3:30PM - 4:30PM
Workshop 2B: New Drugs for Diabetes
Room: Longs/Grays Peaks

Speaker 5 of 5
Safina Ali, Samuel Lunenfeld Research Institute, Canada
Disruption of Cardiomyocyte Glucagon Receptor Signaling Decreases Flux through Fatty Acid Oxidation and Enhances Survival Following Ischemic Injury

Wednesday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 30 | 5:00PM - 7:00PM
Gastric Bypass Surgery and the Gut in Control of Metabolism
Room: Longs/Grays Peaks

Speaker 1 of 5
* Mary-Elizabeth Patti, Joslin Diabetes Center, USA

Wednesday, January 30 | 5:00PM - 7:00PM
Gastric Bypass Surgery and the Gut in Control of Metabolism
Room: Longs/Grays Peaks

Speaker 2 of 5
David E. Cummings, University of Washington, USA
Metabolic Surgery: Endocrine Mechanisms of Diabetes Remission after 'Bariatric' Operations

Wednesday, January 30 | 5:00PM - 7:00PM
Gastric Bypass Surgery and the Gut in Control of Metabolism
Room: Longs/Grays Peaks

Speaker 3 of 5
Daniel D. Kaplan, NGM Biopharmaceuticals, Inc., USA
New Gut Mediators of Bypass Surgery

Wednesday, January 30 | 5:00PM - 7:00PM
Gastric Bypass Surgery and the Gut in Control of Metabolism
Room: Longs/Grays Peaks

Speaker 4 of 5
Lee M. Kaplan, Massachusetts General Hospital, USA
Contributions of the Gut Microbiota to the Physiological Response to Geriatric Bypass

Wednesday, January 30 | 5:00PM - 7:00PM
Gastric Bypass Surgery and the Gut in Control of Metabolism
Room: Longs/Grays Peaks

Speaker 5 of 5
Line V. Kristensen, University of Copenhagen, Denmark
Short Talk: GPR40, GPR120 and GPR119 Act in Concert as Enteroendocrine Sensors for Dietary Fat

Wednesday, January 30 | 5:00PM - 7:00PM
Variation in the Biology of Adipose Depots
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 1 of 5
* Jacqueline M. Stephens, Louisiana State University, USA


Wednesday, January 30 | 5:00PM - 7:00PM
Variation in the Biology of Adipose Depots
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 2 of 5
Susan K. Fried, Icahn School of Medicine at Mount Sinai, USA
Fat Distribution in Men and Women: The Biology of Pear Shape


Wednesday, January 30 | 5:00PM - 7:00PM
Variation in the Biology of Adipose Depots
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 3 of 5
James L. Kirkland, Mayo Clinic, USA
Cellular Senescence and Adipose Tissue


Wednesday, January 30 | 5:00PM - 7:00PM
Variation in the Biology of Adipose Depots
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 4 of 5
Elise C. Jeffery, Yale University, USA
Short Talk: Regulation of Adipocyte Precursor Cells in Obesity


Wednesday, January 30 | 5:00PM - 7:00PM
Variation in the Biology of Adipose Depots
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 5 of 5
Sagar P. Bapat, University of California, San Francisco, USA
Short Talk: Sexually Dimorphic Properties of Fat Resident Regulatory T Cells


Wednesday, January 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom


Wednesday, January 30 | 7:30PM - 10:00PM
Poster Session 3
Room: Colorado Rockies Ballroom


Thursday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Thursday, January 31 | 8:00AM - 11:00AM
Metabolic Mediators of Insulin Resistance
Room: Longs/Grays Peaks

Speaker 1 of 7
* Jeffrey Flier, Harvard University, USA

Thursday, January 31 | 8:00AM - 11:00AM
Metabolic Mediators of Insulin Resistance
Room: Longs/Grays Peaks

Speaker 2 of 7
* Barbara C. Hansen, University of South Florida, Tampa, USA

Thursday, January 31 | 8:00AM - 11:00AM
Metabolic Mediators of Insulin Resistance
Room: Longs/Grays Peaks

Speaker 3 of 7
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Inflammation, UPR and Lipids: All about Stress and Toxicity?

Thursday, January 31 | 8:00AM - 11:00AM
Metabolic Mediators of Insulin Resistance
Room: Longs/Grays Peaks

Speaker 4 of 7
Gerald I. Shulman, Yale University School of Medicine, USA
Novel PKCs as Mediators of Liver and Muscle Insulin Resistance in Humans

Thursday, January 31 | 8:00AM - 11:00AM
Metabolic Mediators of Insulin Resistance
Room: Longs/Grays Peaks

Speaker 5 of 7
Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Endoplasmic Reticulum Stress as a Mediator of Insulin Resistance

Thursday, January 31 | 8:00AM - 11:00AM
Metabolic Mediators of Insulin Resistance
Room: Longs/Grays Peaks

Speaker 6 of 7
Greg Steinberg, McMaster University, Canada
AMP-Activated Protein Kinase (AMPK) Regulation of Lipid Metabolism and Insulin Sensitivity

Thursday, January 31 | 8:00AM - 11:00AM
Metabolic Mediators of Insulin Resistance
Room: Longs/Grays Peaks

Speaker 7 of 7
Alexei Kharitonenkov, Novo Nordisk, USA
Short Talk: Rational Design and Efficacy of LY2405319, an FGF21-Based Clinical Candidate

Thursday, January 31 | 8:00AM - 11:00AM
Brown Adipose Tissue: Where There Is Smoke...
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 1 of 6
* Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA


Thursday, January 31 | 8:00AM - 11:00AM
Brown Adipose Tissue: Where There Is Smoke...
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 2 of 6
Stephen R. Farmer, Boston University School of Medicine, USA
Progenitor Morphology and Development of Beige Adipocytes


Thursday, January 31 | 8:00AM - 11:00AM
Brown Adipose Tissue: Where There Is Smoke...
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 3 of 6
Sheila Collins, Vanderbilt University Medical Center, USA
Converging Hormonal Signals that 'Spark' the Brown-in-White Adipocyte Expansion


Thursday, January 31 | 8:00AM - 11:00AM
Brown Adipose Tissue: Where There Is Smoke...
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 4 of 6
Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA
Cross Talk between Constitutive and Recruitable Brown Adipose Tissues for Thermoregulation and Energy Homeostasis


Thursday, January 31 | 8:00AM - 11:00AM
Brown Adipose Tissue: Where There Is Smoke...
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 5 of 6
Sona Rajakumari, University of Pennsylvania, USA
Short Talk: EBF2 Determines and Maintains Brown Adipocyte Identity


Thursday, January 31 | 8:00AM - 11:00AM
Brown Adipose Tissue: Where There Is Smoke...
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 6 of 6
Xingxing Kong, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Short Talk: Thermogenic Actions of Interferon Regulatory Factor 4 (IRF4)


Thursday, January 31 | 9:00AM - 9:20AM
Coffee Break
Room: Longs Peak Foyer


Thursday, January 31 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Assessing Immune Cell Populations in Adipose Tis
sue: What Are the FACS?
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 1 of 8
* Anthony W. Ferrante, Columbia University, USA


Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Assessing Immune Cell Populations in Adipose Tis
sue: What Are the FACS?
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 2 of 8
Yoshihiro Ogawa, Kyushu University, Japan
Role of Macrophage-Inducible C-Type Lectin in Obesity-Induced Adipose Tissue Inflammation


Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Assessing Immune Cell Populations in Adipose Tis
sue: What Are the FACS?
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 3 of 8
Dwight J. Klemm, University of Colorado Denver Anschutz Medical Center, USA
Soluble Adipose Tissue Factors Stimulate de Novo Differentiation of Bona Fide Adipocytes from Bone Marrow Myeloid Cells


Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Assessing Immune Cell Populations in Adipose Tis
sue: What Are the FACS?
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 4 of 8
John S. Parks, Wake Forest School of Medicine, USA
Dietary Cholesterol Promotes Adipocyte Hypertrophy and Inflammation in Visceral, But Not Subcutaneous, Fat in Non-Human Primates


Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Assessing Immune Cell Populations in Adipose Tis
sue: What Are the FACS?
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 5 of 8
Tal Pecht, Ben-Gurion University of the Negev, Israel
Adipose Tissue Foam Cells in Human Obesity


Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Assessing Immune Cell Populations in Adipose Tis
sue: What Are the FACS?
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 6 of 8
Marek Wagner, University of Bergen, Norway
Adipose Tissue-Derived Macrophages, Endothelial Cells and Cancer


Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Assessing Immune Cell Populations in Adipose Tis
sue: What Are the FACS?
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 7 of 8
Nicolas Venteclef, Institute of Cardiometabolism and Nutrition, France
Dysregulation of a GPS2/SMRT Corepressor Pathway in Adipocytes Coincides with Adipose Tissue Inflammation in Human Obesity


Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Assessing Immune Cell Populations in Adipose Tis
sue: What Are the FACS?
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 8 of 8
Maryam Rakhshandehroo, Utrecht Medical Center, Netherlands
iNKTs in Adipose Tissue Prevent Insulin Resistance


Thursday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 31 | 5:00PM - 7:00PM
CNS Control of Metabolism
Room: Longs/Grays Peaks

Speaker 1 of 5
* Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany

Thursday, January 31 | 5:00PM - 7:00PM
CNS Control of Metabolism
Room: Longs/Grays Peaks

Speaker 2 of 5
Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
Investigating Autonomic Regulatory Networks Controlling Energy Balance and Glucose Homeostasis

Thursday, January 31 | 5:00PM - 7:00PM
CNS Control of Metabolism
Room: Longs/Grays Peaks

Speaker 3 of 5
Christoph Buettner, Mount Sinai School of Medicine, USA
CNS Control of Adipose Tissue Functionality

Thursday, January 31 | 5:00PM - 7:00PM
CNS Control of Metabolism
Room: Longs/Grays Peaks

Speaker 4 of 5
Richard M. Caprioli, Vanderbilt University Medical Center, USA
Imaging Mass Spectrometry: A New Technology for the Direct Mapping of Endogenous Compounds in Tissue

Thursday, January 31 | 5:00PM - 7:00PM
CNS Control of Metabolism
Room: Longs/Grays Peaks

Speaker 5 of 5
Celine E. Riera, Cedars-Sinai Medical Center, USA
Short Talk: Neuroendocrine Regulation of the Calcineurin/CRTC1 Longevity Circuit in C. elegans and Mice

Thursday, January 31 | 5:00PM - 7:00PM
Beyond Diabetes - Complications of Obesity
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 1 of 5
* Ira J. Goldberg, New York University, USA


Thursday, January 31 | 5:00PM - 7:00PM
Beyond Diabetes - Complications of Obesity
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 2 of 5
Kathryn J. Moore, New York University Medical Center, USA
Mechanisms of Macrophage Retention in Metabolic Diseases


Thursday, January 31 | 5:00PM - 7:00PM
Beyond Diabetes - Complications of Obesity
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 3 of 5
Mikhail G. Kolonin, University of Texas Health Sciences Center, USA
Regulation of Tumor Progression by Adipose Tissue


Thursday, January 31 | 5:00PM - 7:00PM
Beyond Diabetes - Complications of Obesity
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 4 of 5
Scott A. Small, Columbia University, USA
Branch-Chained Amino Acids Link Obesity/T2DM and Alzheimer’s Disease through Retromer Deficiency


Thursday, January 31 | 5:00PM - 7:00PM
Beyond Diabetes - Complications of Obesity
This session is from Adipose Tissue
Room: Quandary Peak

Speaker 5 of 5
Roberta Goncalves Marangoni, Northwestern University, USA
Short Talk: Aberrant Adipogenesis in the Pathogenesis of Scleroderma


Thursday, January 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom


Thursday, January 31 | 8:00PM - 11:00PM
Entertainment
Room: Colorado Rockies Ballroom


Thursday, January 31 | 8:00PM - 11:00PM
Cash Bar
Room: Colorado Rockies Ballroom


Friday, February 01 | 10:25AM - 10:25AM
Departure


*Session Chair.