Web Desc
Pulmonary Vascular Disease and Right Ventricular Dysfunction: Current Concepts and Future Therapies
Organizer(s): Georg Hansmann, Stephen L. Archer and Margaret R. MacLean
Date: September 10 - 15, 2012
Location: Portola Hotel & Spa, Monterey, CA, USA
Sponsored by Bayer USA Foundation
Summary of Meeting:
Pulmonary arterial hypertension (PAH) is characterized by progressive obliteration of pulmonary arterioles leading to increased pulmonary vascular resistance, right heart failure and death in 40-60% of PAH patients five years after diagnosis. Proliferation, migration and resistance to apoptosis of vascular cells, as well as proliferative-inflammatory responses mediated by blood and fat cells, contribute to disease development. Despite more than 15 published randomized controlled trials (RCT) that demonstrated moderate effectiveness in improving exercise capacity, the approved PH drugs have not led to a cure. Hence, basic science and translational research focusing on the discovery of novel pathways in pulmonary vascular disease and right ventricular dysfunction, new drug targets, development of novel therapeutic paradigms, cell-based and pharmacotherapies, and their translation into RCTs, is urgently needed. This Keystone Symposia meeting will gather basic and clinical researchers working in the field of pulmonary vascular disease and right ventricular dysfunction. The focus is on basic science with strong impact on 1) our understanding of this fatal disease and 2) discoveries with great potential to be translated into clinical practice in the near future. Late-breaking clinical studies on novel PAH therapies will also be presented.
Scholarship Deadline: June 7 2012
Discounted Abstract Deadline: June 7 2012
Abstract Deadline: June 21 2012
Discounted Registration Deadline: July 10 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer USA Foundation
We gratefully acknowledge additional support for this conference from:

American Heart Association's Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation

American Heart Association's Council on Cardiovascular Disease in the Young
$1 - $2,499

Pulmonary Circulation / Pulmonary Vascular Research Institute

Pulmonary Hypertension Association
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Pulmonary Circulation / Pulmonary Vascular Research InstitutePulmonary Hypertension Association
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, September 10 | 4:00PM - 8:00PM
Arrival and Registration
Room: De Anza Foyer


Tuesday, September 11 | 7:30AM - 8:30AM
Breakfast
Room: De Anza 1-2


Tuesday, September 11 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: De Anza 3

Speaker 1 of 1
Stefanie Dimmeler, University of Frankfurt, Germany
The Role of Stem Cells in Angiogenesis and Vascular Repair

Tuesday, September 11 | 9:30AM - 12:45PM
The Role of Stem Cells, Progenitor and Differentiated Blood
Cells in Pulmonary Vascular Disease and Repair

Room: De Anza 3

Speaker 1 of 7
* Duncan J. Stewart, Ottawa Hospital Research Institute, Canada

Tuesday, September 11 | 9:30AM - 12:45PM
The Role of Stem Cells, Progenitor and Differentiated Blood
Cells in Pulmonary Vascular Disease and Repair

Room: De Anza 3

Speaker 2 of 7
Stella Kourembanas, Children's Hospital Boston, Harvard Medical School, USA
Role of Bone Marrow Stromal Cells in the Repair of Chronic Lung and Pulmonary Vascular Disease

Tuesday, September 11 | 9:30AM - 12:45PM
The Role of Stem Cells, Progenitor and Differentiated Blood
Cells in Pulmonary Vascular Disease and Repair

Room: De Anza 3

Speaker 3 of 7
Margaret R. MacLean, University of Glasgow, UK
Serotonin and Estrogen in the Development of Pulmonary Arterial Hypertension

Tuesday, September 11 | 9:30AM - 12:45PM
The Role of Stem Cells, Progenitor and Differentiated Blood
Cells in Pulmonary Vascular Disease and Repair

Room: De Anza 3

Speaker 4 of 7
Paul M. Hassoun, Johns Hopkins University, USA
Cross-Talk between Macrophages, Granulocytes and Vascular Cells in Pulmonary Vascular Diseases

Tuesday, September 11 | 9:30AM - 12:45PM
The Role of Stem Cells, Progenitor and Differentiated Blood
Cells in Pulmonary Vascular Disease and Repair

Room: De Anza 3

Speaker 5 of 7
Mark L. Ormiston, University of Cambridge, UK
Short Talk: Impaired Natural Killer Cell Phenotype and Function in Pulmonary Arterial Hypertension and Animal Models of Disease

Tuesday, September 11 | 9:30AM - 12:45PM
The Role of Stem Cells, Progenitor and Differentiated Blood
Cells in Pulmonary Vascular Disease and Repair

Room: De Anza 3

Speaker 6 of 7
Izabela M. Chrobak, Boston University School of Medicine, USA
Short Talk: Endothelial GATA6 Deficiency Promotes Pulmonary Arterial Hypertension

Tuesday, September 11 | 9:30AM - 12:45PM
The Role of Stem Cells, Progenitor and Differentiated Blood
Cells in Pulmonary Vascular Disease and Repair

Room: De Anza 3

Speaker 7 of 7
Duncan J. Stewart, Ottawa Hospital Research Institute, Canada
Progenitor Cell Transplantation for Pulmonary Hypertension

Tuesday, September 11 | 10:50AM - 11:10AM
Coffee Break
Room: De Anza Foyer


Tuesday, September 11 | 12:45PM - 1:15PM
Poster Setup
Room: De Anza 1-2


Tuesday, September 11 | 12:45PM - 2:30PM
On Own for Lunch and Recreation


Tuesday, September 11 | 1:15PM - 10:00PM
Poster Viewing
Room: De Anza 1-2


Tuesday, September 11 | 2:30PM - 4:30PM
Workshop 1: How to Translate Basic Research Findings into Im
provement of Patient Care - The Role of Industry
Room: De Anza 3

Speaker 1 of 5
Lynn Raju Punnoose, New York Presbyterian Weill Cornell, USA
Lessons from Computerized Models on Right Ventricular Assist Devices in Pulmonary Arterial Hypertension

Tuesday, September 11 | 2:30PM - 4:30PM
Workshop 1: How to Translate Basic Research Findings into Im
provement of Patient Care - The Role of Industry
Room: De Anza 3

Speaker 2 of 5
Evelyn M. Horn, Weill Cornell, USA
Support for the Failing RV in PAH

Tuesday, September 11 | 2:30PM - 4:30PM
Workshop 1: How to Translate Basic Research Findings into Im
provement of Patient Care - The Role of Industry
Room: De Anza 3

Speaker 3 of 5
Matthew Thomas, Novartis Institutes for BioMedical Research, UK
Anti-Remodeling Therapies for Pulmonary Arterial Hypertension: Challenges for Drug Discovery

Tuesday, September 11 | 2:30PM - 4:30PM
Workshop 1: How to Translate Basic Research Findings into Im
provement of Patient Care - The Role of Industry
Room: De Anza 3

Speaker 4 of 5
* Stuart Rich, University of Chicago Medical Center, USA
Panelist

Tuesday, September 11 | 2:30PM - 4:30PM
Workshop 1: How to Translate Basic Research Findings into Im
provement of Patient Care - The Role of Industry
Room: De Anza 3

Speaker 5 of 5
Timothy M. Moore, NHLBI, National Institutes of Health, USA
Panelist

Tuesday, September 11 | 4:30PM - 5:00PM
Coffee Available
Room: De Anza Foyer


Tuesday, September 11 | 5:00PM - 7:00PM
Growth Factors, TGF-beta/BMP Signaling and Pulmonary Vascula
r Disease

Room: De Anza 3

Speaker 1 of 6
* Georg Hansmann, Hannover Medical School, Germany

Tuesday, September 11 | 5:00PM - 7:00PM
Growth Factors, TGF-beta/BMP Signaling and Pulmonary Vascula
r Disease

Room: De Anza 3

Speaker 2 of 6
* Paul M. Hassoun, Johns Hopkins University, USA

Tuesday, September 11 | 5:00PM - 7:00PM
Growth Factors, TGF-beta/BMP Signaling and Pulmonary Vascula
r Disease

Room: De Anza 3

Speaker 3 of 6
Marc Humbert, Hôpital Antoine-Béclère, AP-HP, France
New Insights into the Role of Cytokines, Chemokines and Growth Factors in Pulmonary Arterial Hypertension

Tuesday, September 11 | 5:00PM - 7:00PM
Growth Factors, TGF-beta/BMP Signaling and Pulmonary Vascula
r Disease

Room: De Anza 3

Speaker 4 of 6
Kenneth D. Bloch, Massachusetts General Hospital, USA
Role of BMPR-2 and BMP Signaling in PAH - Lessons from Murine Models

Tuesday, September 11 | 5:00PM - 7:00PM
Growth Factors, TGF-beta/BMP Signaling and Pulmonary Vascula
r Disease

Room: De Anza 3

Speaker 5 of 6
Mark P. de Caestecker, Vanderbilt University, USA
Short Talk: Chemical Chaperones Correct BMP Receptor Processing Errors in Hereditary Pulmonary Arterial Hypertension (HPAH)

Tuesday, September 11 | 5:00PM - 7:00PM
Growth Factors, TGF-beta/BMP Signaling and Pulmonary Vascula
r Disease

Room: De Anza 3

Speaker 6 of 6
Patricia A. Thistlethwaite, University of California, San Diego, USA
Notch Signaling in Pulmonary Vascular Disease

Tuesday, September 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: De Anza 1-2


Tuesday, September 11 | 7:30PM - 10:00PM
Poster Session 1
Room: De Anza 1-2


Wednesday, September 12 | 7:30AM - 8:30AM
Breakfast
Room: De Anza 1-2


Wednesday, September 12 | 8:30AM - 11:45AM
Metabolic Regulators in Pulmonary Vascular Disease
Room: De Anza 3

Speaker 1 of 7
* Stephen L. Archer, Queen's University, Canada

Wednesday, September 12 | 8:30AM - 11:45AM
Metabolic Regulators in Pulmonary Vascular Disease
Room: De Anza 3

Speaker 2 of 7
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Vascular Metabolomics

Wednesday, September 12 | 8:30AM - 11:45AM
Metabolic Regulators in Pulmonary Vascular Disease
Room: De Anza 3

Speaker 3 of 7
Georg Hansmann, Hannover Medical School, Germany
The Protective Role of PPARgamma in Pulmonary Vascular Disease

Wednesday, September 12 | 8:30AM - 11:45AM
Metabolic Regulators in Pulmonary Vascular Disease
Room: De Anza 3

Speaker 4 of 7
Evangelos D. Michelakis, University of Alberta Hospital, Canada
Mitochondrial Modulators in Pulmonary Arterial Hypertension

Wednesday, September 12 | 8:30AM - 11:45AM
Metabolic Regulators in Pulmonary Vascular Disease
Room: De Anza 3

Speaker 5 of 7
Yong-Hu Fang, University of Chicago, USA
Short Talk: Inhibition of Glutaminolysis by 6-Diazo-5-Oxo-l-Norleucine (DON) Improves Right Ventricular Function in Monocrotaline Induced Pulmonary Hypertension

Wednesday, September 12 | 8:30AM - 11:45AM
Metabolic Regulators in Pulmonary Vascular Disease
Room: De Anza 3

Speaker 6 of 7
Kirsty M. Mair, University of Glasgow, UK
Short Talk: Beneficial Effects of an Aromatase Inhibitor in Established Hypoxia-Induced Pulmonary Arterial Hypertension

Wednesday, September 12 | 8:30AM - 11:45AM
Metabolic Regulators in Pulmonary Vascular Disease
Room: De Anza 3

Speaker 7 of 7
Nicholas Morrell, University of Cambridge, UK
Generation of Patient-Derived Induced Pluripotent Stem Cells to Study BMP Receptor Dysfunction

Wednesday, September 12 | 9:50AM - 10:10AM
Coffee Break
Room: De Anza Foyer


Wednesday, September 12 | 11:45AM - 1:00PM
Poster Setup
Room: De Anza 1-2


Wednesday, September 12 | 11:45AM - 2:30PM
On Own for Lunch and Recreation


Wednesday, September 12 | 1:00PM - 10:00PM
Poster Viewing
Room: De Anza 1-2


Wednesday, September 12 | 2:30PM - 4:30PM
Workshop 2: MicroRNAs and iPS Cells - Novel Tools and Target
s in Cardiovascular Biology and Pulmonary Vascular Research
Room: De Anza 3

Speaker 1 of 6
* Nicholas Morrell, University of Cambridge, UK

Wednesday, September 12 | 2:30PM - 4:30PM
Workshop 2: MicroRNAs and iPS Cells - Novel Tools and Target
s in Cardiovascular Biology and Pulmonary Vascular Research
Room: De Anza 3

Speaker 2 of 6
Jenny Grieve, University of Glasgow, UK
The Role of miR-451 in the Development of Pulmonary Arterial Hypertension (PAH)

Wednesday, September 12 | 2:30PM - 4:30PM
Workshop 2: MicroRNAs and iPS Cells - Novel Tools and Target
s in Cardiovascular Biology and Pulmonary Vascular Research
Room: De Anza 3

Speaker 3 of 6
Kylie M. Drake, Cleveland Clinic, USA
Treatment with Chloroquine Rescues Smad-Mediated microRNA Processing in Heritable Pulmonary Arterial Hypertension

Wednesday, September 12 | 2:30PM - 4:30PM
Workshop 2: MicroRNAs and iPS Cells - Novel Tools and Target
s in Cardiovascular Biology and Pulmonary Vascular Research
Room: De Anza 3

Speaker 4 of 6
Guillaume Margaillan, Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Canada
miR-204 Accounts for HIF-1alpha Activation in Both Human and Experimental Pulmonary Arterial Hypertension

Wednesday, September 12 | 2:30PM - 4:30PM
Workshop 2: MicroRNAs and iPS Cells - Novel Tools and Target
s in Cardiovascular Biology and Pulmonary Vascular Research
Room: De Anza 3

Speaker 5 of 6
Allison R. Prewitt, Vanderbilt University, USA
Caveolar Defects in Hereditary Pulmonary Arterial Hypertension (HPAH)

Wednesday, September 12 | 2:30PM - 4:30PM
Workshop 2: MicroRNAs and iPS Cells - Novel Tools and Target
s in Cardiovascular Biology and Pulmonary Vascular Research
Room: De Anza 3

Speaker 6 of 6
Edda Spiekerkoetter, Stanford University, USA
FK506 - Identified in a High-Throughput Screen to Increase BMPR2 Signaling - Reverses Pulmonary Hypertension by Rescuing Endothelial Dysfunction

Wednesday, September 12 | 4:30PM - 5:00PM
Coffee Available
Room: De Anza Foyer


Wednesday, September 12 | 5:00PM - 7:00PM
The Right Ventricle in Pulmonary Hypertension: Cardiomyocyte
Function and Hemodynamic Performance

Room: De Anza 3

Speaker 1 of 5
* Evangelos D. Michelakis, University of Alberta Hospital, Canada

Wednesday, September 12 | 5:00PM - 7:00PM
The Right Ventricle in Pulmonary Hypertension: Cardiomyocyte
Function and Hemodynamic Performance

Room: De Anza 3

Speaker 2 of 5
Stephen L. Archer, Queen's University, Canada
Right Ventricular Function and Metabolism in Pulmonary Hypertension: Mechanisms and Potential Metabolic Therapies

Wednesday, September 12 | 5:00PM - 7:00PM
The Right Ventricle in Pulmonary Hypertension: Cardiomyocyte
Function and Hemodynamic Performance

Room: De Anza 3

Speaker 3 of 5
Titus Kühne, German Heart Institute, Germany
Assessment of Right Ventricular Function by MRI and Pressure-Volume Loops

Wednesday, September 12 | 5:00PM - 7:00PM
The Right Ventricle in Pulmonary Hypertension: Cardiomyocyte
Function and Hemodynamic Performance

Room: De Anza 3

Speaker 4 of 5
Andrew Redington, Hospital for Sick Children, Canada
Interactions between Right and Left Ventricle in Pulmonary Hypertension

Wednesday, September 12 | 5:00PM - 7:00PM
The Right Ventricle in Pulmonary Hypertension: Cardiomyocyte
Function and Hemodynamic Performance

Room: De Anza 3

Speaker 5 of 5
Simon C. Rowan, University College Dublin, Republic of Ireland, Ireland
Short Talk: Haploinsufficiency of Gremlin Augments NOS Expression and Activity in the Hypoxic Pulmonary Circulation

Wednesday, September 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: De Anza 1-2


Wednesday, September 12 | 7:30PM - 10:00PM
Poster Session 2
Room: De Anza 1-2


Thursday, September 13 | 7:30AM - 8:30AM
Breakfast
Room: De Anza 1-2


Thursday, September 13 | 8:30AM - 11:30AM
MicroRNAs in Proliferative Vascular Disease
Room: De Anza 3

Speaker 1 of 6
* Margaret R. MacLean, University of Glasgow, UK

Thursday, September 13 | 8:30AM - 11:30AM
MicroRNAs in Proliferative Vascular Disease
Room: De Anza 3

Speaker 2 of 6
Andrew H. Baker, University of Edinburgh, UK
MicroRNAs in Vascular Remodeling and PAH

Thursday, September 13 | 8:30AM - 11:30AM
MicroRNAs in Proliferative Vascular Disease
Room: De Anza 3

Speaker 3 of 6
Norbert F. Voelkel, Virginia Commonwealth University, USA
Histone Deactylation in the Right Ventricle and Pulmonary Vasculature

Thursday, September 13 | 8:30AM - 11:30AM
MicroRNAs in Proliferative Vascular Disease
Room: De Anza 3

Speaker 4 of 6
Sebastien Bonnet, Université Laval, Canada
Role for DNA Repair and miRNAs in the Epigenetics Abnormalities Seen in PAH

Thursday, September 13 | 8:30AM - 11:30AM
MicroRNAs in Proliferative Vascular Disease
Room: De Anza 3

Speaker 5 of 6
Pawel Stankiewicz, Baylor College of Medicine, USA
Short Talk: Deletions of lncRNAs Cause a Lethal Lung Developmental Disorder Showing Parent of Origin Effects

Thursday, September 13 | 8:30AM - 11:30AM
MicroRNAs in Proliferative Vascular Disease
Room: De Anza 3

Speaker 6 of 6
Roxane Paulin, University of Alberta, Canada
Short Talk: A MicroRNA Signature Characterizing the Transition from a Compensated to a Decompensated Right Ventricle

Thursday, September 13 | 9:50AM - 10:10AM
Coffee Break
Room: De Anza Foyer


Thursday, September 13 | 11:30AM - 2:30PM
On Own for Lunch and Recreation


Thursday, September 13 | 2:30PM - 3:00PM
Coffee Available
Room: De Anza Foyer


Thursday, September 13 | 3:00PM - 5:00PM
Innovative Clinical PAH Trials
Room: De Anza 3

Speaker 1 of 6
Evangelos D. Michelakis, University of Alberta Hospital, Canada
and

Thursday, September 13 | 3:00PM - 5:00PM
Innovative Clinical PAH Trials
Room: De Anza 3

Speaker 2 of 6
Martin R. Wilkins, Imperial College London, UK
Dichloroacetate (DCA) for the Treatment of Pulmonary Hypertension

Thursday, September 13 | 3:00PM - 5:00PM
Innovative Clinical PAH Trials
Room: De Anza 3

Speaker 3 of 6
Stuart Rich, University of Chicago Medical Center, USA
Clinical Trial Design Issues in Pulmonary Hypertension

Thursday, September 13 | 3:00PM - 5:00PM
Innovative Clinical PAH Trials
Room: De Anza 3

Speaker 4 of 6
Mark R. Nicolls, Stanford University School of Medicine, USA
Targeting Immunity in the Treatment of PAH: The Rituximab SSc-PAH Trial

Thursday, September 13 | 3:00PM - 5:00PM
Innovative Clinical PAH Trials
Room: De Anza 3

Speaker 5 of 6
* Marc Humbert, Hôpital Antoine-Béclère, AP-HP, France
Panelist

Thursday, September 13 | 3:00PM - 5:00PM
Innovative Clinical PAH Trials
Room: De Anza 3

Speaker 6 of 6
Duncan J. Stewart, Ottawa Hospital Research Institute, Canada
Panelist

Thursday, September 13 | 5:00PM - 6:00PM
Social Hour with Lite Bites
Room: De Anza 1-2


Thursday, September 13 | 6:00PM - 6:00PM
On Own for Dinner


Friday, September 14 | 7:30AM - 8:30AM
Breakfast
Room: De Anza 1-2


Friday, September 14 | 8:30AM - 11:45AM
Pulmonary Hypertension in Parenchymal Lung and Thromboemboli
c Diseases

Room: De Anza 3

Speaker 1 of 7
* Stella Kourembanas, Children's Hospital Boston, Harvard Medical School, USA

Friday, September 14 | 8:30AM - 11:45AM
Pulmonary Hypertension in Parenchymal Lung and Thromboemboli
c Diseases

Room: De Anza 3

Speaker 2 of 7
* Mark A. Krasnow, Stanford University School of Medicine, USA
Building the Pulmonary Artery

Friday, September 14 | 8:30AM - 11:45AM
Pulmonary Hypertension in Parenchymal Lung and Thromboemboli
c Diseases

Room: De Anza 3

Speaker 3 of 7
Bernard Thébaud, Ottawa Hospital Research Institute, Canada
Progenitor Cells in Diaphragmatic Hernia, Pulmonary Hypoplasia and PH Associated with Neonatal Lung Injury

Friday, September 14 | 8:30AM - 11:45AM
Pulmonary Hypertension in Parenchymal Lung and Thromboemboli
c Diseases

Room: De Anza 3

Speaker 4 of 7
Jane A. Mitchell, Imperial College London, UK
The Role of PPAR beta/delta in Pulmonary Hypertension

Friday, September 14 | 8:30AM - 11:45AM
Pulmonary Hypertension in Parenchymal Lung and Thromboemboli
c Diseases

Room: De Anza 3

Speaker 5 of 7
Lei Zhou, Texas Heart Institute, USA
Short Talk: ELPC-Based Prostacyclin Gene Therapy Rescues Monocrotaline-Induced Pulmonary Arterial Hypertension

Friday, September 14 | 8:30AM - 11:45AM
Pulmonary Hypertension in Parenchymal Lung and Thromboemboli
c Diseases

Room: De Anza 3

Speaker 6 of 7
Stuart W. Jamieson, University of California, San Diego Medical Center, USA
Pulmonary Hypertension as a Result of Chronic Pulmonary Embolism-Surgical Treatment

Friday, September 14 | 8:30AM - 11:45AM
Pulmonary Hypertension in Parenchymal Lung and Thromboemboli
c Diseases

Room: De Anza 3

Speaker 7 of 7
Aiko Ogawa, National Hospital Organization Okayama Medical Center, Japan
Short Talk: Thrombin Induces Proliferation of Cells from Patients with Chronic Thromboembolic Pulmonary Hypertension via Akt/mTOR Pathway

Friday, September 14 | 9:50AM - 10:10AM
Coffee Break
Room: De Anza Foyer


Friday, September 14 | 11:45AM - 2:30PM
On Own for Lunch and Recreation


Friday, September 14 | 2:30PM - 4:30PM
Workshop 3: Vascular Metabolomics and Proteomics: Where Are
the Novel Biomarkers for Pulmonary Vascular Diseases?
Room: De Anza 3

Speaker 1 of 7
* Martin R. Wilkins, Imperial College London, UK

Friday, September 14 | 2:30PM - 4:30PM
Workshop 3: Vascular Metabolomics and Proteomics: Where Are
the Novel Biomarkers for Pulmonary Vascular Diseases?
Room: De Anza 3

Speaker 2 of 7
Alex M.K. Rothman, University of Sheffield, UK
Whole Blood miRNA Expression in Pulmonary Arterial Hypertension (PAH) Reveals Down-Regulation of MicroRNA-140-5p in Idiopathic and Scleroderma-Associated PAH

Friday, September 14 | 2:30PM - 4:30PM
Workshop 3: Vascular Metabolomics and Proteomics: Where Are
the Novel Biomarkers for Pulmonary Vascular Diseases?
Room: De Anza 3

Speaker 3 of 7
Jessie R. Lavoie, Ottawa Hospital Research Institute, Canada
Proteomic Analysis Identifies Translationally Controlled Tumor Protein (TCTP) as a Potential Novel Mediator of Occlusive Vascular Remodeling in Pulmonary Arterial Hypertension

Friday, September 14 | 2:30PM - 4:30PM
Workshop 3: Vascular Metabolomics and Proteomics: Where Are
the Novel Biomarkers for Pulmonary Vascular Diseases?
Room: De Anza 3

Speaker 4 of 7
Ferhaan Ahmad, University of Iowa, USA
Pulmonary Arterial Hypertension Induces Gene Expression Changes in the Right Ventricle in Advance of Right Ventricular Failure that Are More Severe in Female Rats

Friday, September 14 | 2:30PM - 4:30PM
Workshop 3: Vascular Metabolomics and Proteomics: Where Are
the Novel Biomarkers for Pulmonary Vascular Diseases?
Room: De Anza 3

Speaker 5 of 7
Giovanna Frazziano, Ri.MED Foundation/ISMETT, Italy
Nox-Derived ROS Is Increased in a Model of Pressure Overload in Mouse Right Ventricle

Friday, September 14 | 2:30PM - 4:30PM
Workshop 3: Vascular Metabolomics and Proteomics: Where Are
the Novel Biomarkers for Pulmonary Vascular Diseases?
Room: De Anza 3

Speaker 6 of 7
Elena A. Goncharova, University of Pennsylvania, USA
mTORC2 Coordinates Energy Metabolism, Proliferation and Survival of Vascular Smooth Muscle Cells in Idiopathic PAH

Friday, September 14 | 2:30PM - 4:30PM
Workshop 3: Vascular Metabolomics and Proteomics: Where Are
the Novel Biomarkers for Pulmonary Vascular Diseases?
Room: De Anza 3

Speaker 7 of 7
Kathryn N. Farrow, Northwestern University, USA
Disruption of cGMP Signaling in Small Pulmonary Arteries Occurs Rapidly and Persists in BPD Mice with Pulmonary Hypertension

Friday, September 14 | 4:30PM - 5:00PM
Coffee Available
Room: De Anza Foyer


Friday, September 14 | 5:00PM - 7:00PM
Pulmonary Arterial Hypertension - Current Concepts and Futur
e Therapies
Room: De Anza 3

Speaker 1 of 7
* Georg Hansmann, Hannover Medical School, Germany

Friday, September 14 | 5:00PM - 7:00PM
Pulmonary Arterial Hypertension - Current Concepts and Futur
e Therapies
Room: De Anza 3

Speaker 2 of 7
* Margaret R. MacLean, University of Glasgow, UK

Friday, September 14 | 5:00PM - 7:00PM
Pulmonary Arterial Hypertension - Current Concepts and Futur
e Therapies
Room: De Anza 3

Speaker 3 of 7
* Stephen L. Archer, Queen's University, Canada

Friday, September 14 | 5:00PM - 7:00PM
Pulmonary Arterial Hypertension - Current Concepts and Futur
e Therapies
Room: De Anza 3

Speaker 4 of 7
Karim Christian El Kasmi, Boehringer Ingelheim Pharma, Germany
Chronic Inflammation, Autoimmunity and Epigenetics: A Critical Drug-Targetable Triumvirate in Pulmonary Hypertension

Friday, September 14 | 5:00PM - 7:00PM
Pulmonary Arterial Hypertension - Current Concepts and Futur
e Therapies
Room: De Anza 3

Speaker 5 of 7
Martin R. Wilkins, Imperial College London, UK
Novel Biomarkers for Pulmonary Vascular Disease and Right Ventricular Dysfunction

Friday, September 14 | 5:00PM - 7:00PM
Pulmonary Arterial Hypertension - Current Concepts and Futur
e Therapies
Room: De Anza 3

Speaker 6 of 7
Stephen L. Archer, Queen's University, Canada

Friday, September 14 | 5:00PM - 7:00PM
Pulmonary Arterial Hypertension - Current Concepts and Futur
e Therapies
Room: De Anza 3

Speaker 7 of 7
Timothy M. Moore, NHLBI, National Institutes of Health, USA
Panelist

Friday, September 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: De Anza 1-2


Friday, September 14 | 8:00PM - 11:00PM
Entertainment
Room: De Anza 1-2


Friday, September 14 | 8:00PM - 11:00PM
Cash Bar
Room: De Anza 1-2


Saturday, September 15 | 10:25AM - 10:25AM
Departure


*Session Chair.