Web Desc
Aging and Diseases of Aging
Organizer(s): Takashi Kadowaki, Leonard P. Guarente, Judith Campisi and Sean M. Oldham
Date: October 22 - 27, 2012
Location: Sheraton Miyako Hotel Tokyo, Tokyo, Japan
Sponsored by Novartis Pharma K.K., Takeda Pharmaceutical Company Limited and Astellas Pharma Inc. Special scholarship support provided by the Japanese Society of Anti-Aging Medicine.
Summary of Meeting:
Age-related diseases and disabilities, such as cancer, diabetes and neuronal degeneration, pose an ever-increasing social and economic burden worldwide. Fortunately, the last decades have witnessed dramatic progress in our understanding of the aging process. Genetic studies in particular have helped elucidate some of the molecular pathways that regulate aging and have offered new insights into the treatment of age-related diseases. However, there is still much to be learned and further progress in addressing the unique challenges of the aging population will require new insights and novel approaches. In order to accelerate the discovery process, this Keystone Symposia meeting will cover essential aspects of the aging processes, including cell signaling pathways, DNA stability, protein homeostasis, stem cells and cellular senescence. Each plenary session will emphasize innovative findings from a variety of models in basic research areas and link them to age-related disease and frailty. The ultimate goal is to provide an opportunity for attendees to communicate and promote an integrated understanding of aging and age-related diseases. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact.
Scholarship Deadline: June 21 2012
Discounted Abstract Deadline: June 21 2012
Abstract Deadline: July 25 2012
Discounted Registration Deadline: August 22 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Novartis Pharma K.K.Takeda Pharmaceutical Company LimitedAstellas Pharma Inc.Japanese Society of Anti-Aging Medicine
We gratefully acknowledge additional support for this conference from:
Biogen IdecDAIICHI SANKYO CO., LTD.The Ellison Medical Foundation
Inoue Foundation for Science
The Naito Foundation
Ono Pharmaceutical Co. Ltd.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Nestlé Institute of Health Sciences


Reiko Inagi
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Co-Action Publishing
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, October 22 | 4:00PM - 8:00PM
Arrival and Registration
Room: Daigo Foyer


Tuesday, October 23 | 6:30AM - 8:30AM
Breakfast
Room: Individual Hotel
Breakfast at Individual Hotel

Tuesday, October 23 | 7:30AM - 8:30AM
Poster Setup
Room: Daigo


Tuesday, October 23 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Daigo

Speaker 3 of 3
David A. Sinclair, Harvard Medical School, USA
Using Sirtuins to Identify Fundamental Causes of Aging and Age-Related Diseases

Tuesday, October 23 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Daigo

Speaker 2 of 3
* Leonard P. Guarente, Massachusetts Institute of Technology, USA
Introduction of Keynote Address

Tuesday, October 23 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Daigo

Speaker 1 of 3
* Takashi Kadowaki, University of Tokyo, Japan
Welcome Speech

Tuesday, October 23 | 8:30AM - 3:00PM
Poster Viewing
Room: Daigo


Tuesday, October 23 | 9:30AM - 12:15PM
Cell Signaling I
Room: Daigo

Speaker 6 of 6
Martin S. Denzel, Max Planck Institute for Biology of Aging, Germany
Short Talk: Enhancing N-Glycosylation via Activation of the Hexosamine Pathway Improves ER Protein Folding Capacity and Slows Aging

Tuesday, October 23 | 9:30AM - 12:15PM
Cell Signaling I
Room: Daigo

Speaker 5 of 6
Laura Bordone, Genomics Institute of the Novartis Research Foundation, USA
Regulation of Glucose and Nitrogen Metabolism by SIRT4

Tuesday, October 23 | 9:30AM - 12:15PM
Cell Signaling I
Room: Daigo

Speaker 4 of 6
Eisuke Nishida, Kyoto University, Japan
A Fasting-Responsive Signaling Network That Extends Life-Span in C. elegans

Tuesday, October 23 | 9:30AM - 12:15PM
Cell Signaling I
Room: Daigo

Speaker 3 of 6
* Marcia C. Haigis, Harvard Medical School, USA
Role of Mitochondrial Metabolism in Diseases of Aging

Tuesday, October 23 | 9:30AM - 12:15PM
Cell Signaling I
Room: Daigo

Speaker 2 of 6
Leonard P. Guarente, Massachusetts Institute of Technology, USA
Aging and Disease: Connections to Sirtuins

Tuesday, October 23 | 9:30AM - 12:15PM
Cell Signaling I
Room: Daigo

Speaker 1 of 6
* Eric M. Verdin, Buck Institute for Research on Aging, USA

Tuesday, October 23 | 10:10AM - 10:30AM
Coffee Break
Room: Foyer


Tuesday, October 23 | 12:15PM - 12:45PM
Lunch
Room: Foyer/Saga


Tuesday, October 23 | 12:30PM - 3:00PM
Poster Session 1
Room: Daigo


Tuesday, October 23 | 2:30PM - 3:00PM
Coffee Available
Room: Foyer


Tuesday, October 23 | 3:00PM - 5:00PM
Cell Signaling II
Room: Daigo

Speaker 6 of 6
Caroline Kumsta, Sanford-Burnham Medical Research Institute, USA
Short Talk: The Integrin-Signaling Complex Regulates Longevity and Thermo-Tolerance via HSF-1 in C. elegans

Tuesday, October 23 | 3:00PM - 5:00PM
Cell Signaling II
Room: Daigo

Speaker 5 of 6
Yousin Suh, Albert Einstein College of Medicine, USA
Functional Genomic Approaches to Human Aging

Tuesday, October 23 | 3:00PM - 5:00PM
Cell Signaling II
Room: Daigo

Speaker 4 of 6
Shin-ichiro Imai, Washington University School of Medicine, USA
The Systemic Regulatory Network for Mammalian Aging and Longevity: The Importance of SIRT1 and NAMPT in the Hypothalamus and Adipose Tissue

Tuesday, October 23 | 3:00PM - 5:00PM
Cell Signaling II
Room: Daigo

Speaker 3 of 6
Sean M. Oldham, Takeda Pharmaceuticals International Co., USA
Role of Nutrient Sensing TOR Pathway in Obesity and Aging

Tuesday, October 23 | 3:00PM - 5:00PM
Cell Signaling II
Room: Daigo

Speaker 2 of 6
* Hiroshi Itoh, Keio University School of Medicine, Japan

Tuesday, October 23 | 3:00PM - 5:00PM
Cell Signaling II
Room: Daigo

Speaker 1 of 6
* David A. Sinclair, Harvard Medical School, USA

Tuesday, October 23 | 5:00PM - 5:00PM
On Own for Dinner


Wednesday, October 24 | 6:30AM - 8:30AM
Breakfast
Room: Individual Hotel
Breakfast at Individual Hotel

Wednesday, October 24 | 8:30AM - 11:45AM
Stem Cells and Aging. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Daigo
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 1 of 7
* Kazuo Tsubota, Keio University School of Medicine, Japan

Wednesday, October 24 | 8:30AM - 11:45AM
Stem Cells and Aging. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Daigo
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 2 of 7
Thomas A. Rando, Stanford University School of Medicine, USA
Epigenetic Mechanisms of Stem Cell Aging and Rejuvenation

Wednesday, October 24 | 8:30AM - 11:45AM
Stem Cells and Aging. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Daigo
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 3 of 7
Heinrich Jasper, Genentech, Inc., USA
Proliferative Homeostasis and Aging of the Adult Intestine of Drosophila

Wednesday, October 24 | 8:30AM - 11:45AM
Stem Cells and Aging. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Daigo
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 4 of 7
Anne Brunet, Stanford University, USA
Epigenetic Regulation of Aging Neural Stem Cells

Wednesday, October 24 | 8:30AM - 11:45AM
Stem Cells and Aging. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Daigo
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 5 of 7
* Amy J. Wagers, Harvard University, USA
Age-Dependent Regulators of Tissue Maintenance and Repair

Wednesday, October 24 | 8:30AM - 11:45AM
Stem Cells and Aging. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Daigo
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 6 of 7
Mineo Kurokawa, Graduate School of Medicine, University of Tokyo, Japan
Short Talk: Regulation of Stem Cells in Normal and Malignant Hematopoiesis

Wednesday, October 24 | 8:30AM - 11:45AM
Stem Cells and Aging. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Daigo
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 7 of 7
Anne H. H. Tseng, Academia Sinica and National Yang Ming University, Taiwan
Short Talk: SIRT3 Crosstalks with FOXO3 Acetylation-Phosphorylation-Ubiquitination to Mediate Hypoxic Adaptation

Wednesday, October 24 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Wednesday, October 24 | 11:45AM - 12:45PM
Poster Setup
Room: Daigo


Wednesday, October 24 | 11:45AM - 4:00PM
Poster Viewing
Room: Daigo


Wednesday, October 24 | 11:45AM - 3:30PM
On Own for Lunch and Recreation


Wednesday, October 24 | 3:30PM - 4:00PM
Coffee Available
Room: Foyer


Wednesday, October 24 | 4:00PM - 6:00PM
Cell Signaling III
Room: Daigo

Speaker 1 of 5
* Ana Maria Cuervo, Albert Einstein College of Medicine, USA

Wednesday, October 24 | 4:00PM - 6:00PM
Cell Signaling III
Room: Daigo

Speaker 2 of 5
* Yo-ichi Nabeshima, Foundation for Biomedical Research and Innovation, Japan
alpha-Klotho in Health and Diseases

Wednesday, October 24 | 4:00PM - 6:00PM
Cell Signaling III
Room: Daigo

Speaker 3 of 5
Noboru Mizushima, University of Tokyo, Japan
Autophagy: Its Regulation Mechanism and Selective Substrates

Wednesday, October 24 | 4:00PM - 6:00PM
Cell Signaling III
Room: Daigo

Speaker 4 of 5
Raul Mostoslavsky, Harvard Medical School, USA
The Chromatin Deacetylase SIRT6 is a Critical Modulator of Cancer Metabolism

Wednesday, October 24 | 4:00PM - 6:00PM
Cell Signaling III
Room: Daigo

Speaker 5 of 5
Bernadette Zwaans, University of Michigan, USA
Short Talk: SIRT6 Promotes Repetitive Element Silencing

Wednesday, October 24 | 6:00PM - 7:00PM
Social Hour with Lite Bites
Room: Foyer/Saga/Daigo


Wednesday, October 24 | 7:00PM - 10:00PM
Poster Session 2
Room: Daigo


Thursday, October 25 | 6:30AM - 8:30AM
Breakfast
Room: Individual Hotel
Breakfast at Individual Hotel

Thursday, October 25 | 7:30AM - 8:30AM
Poster Setup
Room: Daigo


Thursday, October 25 | 8:30AM - 3:00PM
Poster Viewing
Room: Daigo


Thursday, October 25 | 8:30AM - 11:45AM
DNA Damage Response, Telomeres and Cellular Senescence
Room: Daigo

Speaker 1 of 8
* Heinrich Jasper, Genentech, Inc., USA

Thursday, October 25 | 8:30AM - 11:45AM
DNA Damage Response, Telomeres and Cellular Senescence
Room: Daigo

Speaker 2 of 8
* Raul Mostoslavsky, Harvard Medical School, USA

Thursday, October 25 | 8:30AM - 11:45AM
DNA Damage Response, Telomeres and Cellular Senescence
Room: Daigo

Speaker 3 of 8
Judith Campisi, Buck Institute for Research on Aging, USA
The DNA Damage Response, Inflammation, and Aging

Thursday, October 25 | 8:30AM - 11:45AM
DNA Damage Response, Telomeres and Cellular Senescence
Room: Daigo

Speaker 4 of 8
Manuel Serrano, Institute for Research in Biomedicine, Spain
Tumor Suppressors at the Interface between Cancer and Aging

Thursday, October 25 | 8:30AM - 11:45AM
DNA Damage Response, Telomeres and Cellular Senescence
Room: Daigo

Speaker 5 of 8
Naoko Ohtani, Osaka City University Graduate School of Medicine, Japan
Short Talk: Senescence-Associated Secretory Phenotypes (SASPs) Promote Obesity-Associated Hepatocarcinogenesis

Thursday, October 25 | 8:30AM - 11:45AM
DNA Damage Response, Telomeres and Cellular Senescence
Room: Daigo

Speaker 6 of 8
Fuyuki Ishikawa, Kyoto University, Japan
CST Complex in Telomere DNA Replication

Thursday, October 25 | 8:30AM - 11:45AM
DNA Damage Response, Telomeres and Cellular Senescence
Room: Daigo

Speaker 7 of 8
Cynthia T. McMurray, Lawrence Berkeley National Laboratory, USA
Age-Related Instability and Metabolic Status Contribute to Onset of Huntington’s Disease: A Toxic Oxidation Cycle

Thursday, October 25 | 8:30AM - 11:45AM
DNA Damage Response, Telomeres and Cellular Senescence
Room: Daigo

Speaker 8 of 8
Victoria P. Belancio, Tulane University, USA
Short Talk: Circadian Dynamics of L1 Expression in Cancer

Thursday, October 25 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Thursday, October 25 | 12:00PM - 12:45PM
Lunch
Room: Foyer/Saga/Daigo


Thursday, October 25 | 12:30PM - 3:00PM
Poster Session 3
Room: Daigo


Thursday, October 25 | 2:30PM - 3:00PM
Coffee Available
Room: Foyer


Thursday, October 25 | 3:00PM - 5:00PM
Age-Related Neurodegenerative Diseases
Room: Daigo

Speaker 1 of 5
* Cynthia T. McMurray, Lawrence Berkeley National Laboratory, USA

Thursday, October 25 | 3:00PM - 5:00PM
Age-Related Neurodegenerative Diseases
Room: Daigo

Speaker 2 of 5
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Role of Autophagy in Neurodegenerative Diseases

Thursday, October 25 | 3:00PM - 5:00PM
Age-Related Neurodegenerative Diseases
Room: Daigo

Speaker 3 of 5
* Andrew G. Dillin, University of California, Berkeley, USA
Humoral Control of Proteostasis and Aging

Thursday, October 25 | 3:00PM - 5:00PM
Age-Related Neurodegenerative Diseases
Room: Daigo

Speaker 4 of 5
Dale E. Bredesen, Buck Institute for Research on Aging, USA
Role of Cell Death Signaling in Alzheimer's Disease

Thursday, October 25 | 3:00PM - 5:00PM
Age-Related Neurodegenerative Diseases
Room: Daigo

Speaker 5 of 5
Baohua Liu, University of Hong Kong, Hong Kong
Short Talk: Depleting Suv39h1 Methyltransferase Rescues Defective DNA Repair and Extends Lifespan in Progeria Mouse Model

Thursday, October 25 | 5:00PM - 5:00PM
On Own for Dinner


Friday, October 26 | 6:30AM - 8:30AM
Breakfast
Room: Individual Hotel
Breakfast at Individual Hotel

Friday, October 26 | 8:30AM - 11:45AM
Aging and Metabolic Diseases
Room: Daigo

Speaker 1 of 7
* Leonard P. Guarente, Massachusetts Institute of Technology, USA

Friday, October 26 | 8:30AM - 11:45AM
Aging and Metabolic Diseases
Room: Daigo

Speaker 2 of 7
Takashi Kadowaki, University of Tokyo, Japan
AdipoRs Activation Increases Ca2+ and AMPK/SIRT/PGC-1, thereby Regulating Metabolic Stress and Mitochondria, Leading to Anti-Aging and Amelioration of Diseases of Aging

Friday, October 26 | 8:30AM - 11:45AM
Aging and Metabolic Diseases
Room: Daigo

Speaker 3 of 7
* Juleen R. Zierath, Karolinska Institutet, Sweden
Nature or Nurture? Gene/Environment Influence in Skeletal Muscle Insulin Sensitivity in Type 2 Diabetes Patients

Friday, October 26 | 8:30AM - 11:45AM
Aging and Metabolic Diseases
Room: Daigo

Speaker 4 of 7
Carles Canto, Nestlé Institute of Health Sciences, Switzerland
Modulating NAD+ Levels for Targeting Metabolic Disorders and Age-Related Physiological Decline

Friday, October 26 | 8:30AM - 11:45AM
Aging and Metabolic Diseases
Room: Daigo

Speaker 5 of 7
Eric M. Verdin, Buck Institute for Research on Aging, USA
Mitochondrial Sirtuins: Regulators of Protein Acylation and Metabolism

Friday, October 26 | 8:30AM - 11:45AM
Aging and Metabolic Diseases
Room: Daigo

Speaker 6 of 7
Yoshito Takeda, Osaka University Graduate School of Medicine, Japan
Short Talk: Double Deletion of CD9 and CD81 in Mice Leads to a Syndrome Resembling Aging

Friday, October 26 | 8:30AM - 11:45AM
Aging and Metabolic Diseases
Room: Daigo

Speaker 7 of 7
Takashi Ito, Hamamatsu University School of Medicine, Japan
Short Talk: CDC42 and NFkB Signaling Contribute to Pro-Inflammatory Phenotype of Senescent Endothelial Cells

Friday, October 26 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Friday, October 26 | 11:45AM - 4:30PM
On Own for Lunch and Recreation


Friday, October 26 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, October 26 | 5:00PM - 7:00PM
Aging and Cardiovascular Diseases
Room: Daigo

Speaker 1 of 6
* Yasuyoshi Ouchi, Graduate School of Medicine, University of Tokyo, Japan

Friday, October 26 | 5:00PM - 7:00PM
Aging and Cardiovascular Diseases
Room: Daigo

Speaker 2 of 6
* Sean M. Oldham, Takeda Pharmaceuticals International Co., USA

Friday, October 26 | 5:00PM - 7:00PM
Aging and Cardiovascular Diseases
Room: Daigo

Speaker 3 of 6
Edward G. Lakatta, NIA, National Institutes of Health, USA
The Stress of Aging Viewed from the Arterial Wall

Friday, October 26 | 5:00PM - 7:00PM
Aging and Cardiovascular Diseases
Room: Daigo

Speaker 4 of 6
Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Genetics of Cardiac Aging and Dysfunction

Friday, October 26 | 5:00PM - 7:00PM
Aging and Cardiovascular Diseases
Room: Daigo

Speaker 5 of 6
Hiroshi Itoh, Keio University School of Medicine, Japan
Significance of Renal Tubular Sirt1 in Diabetic Nephrophaty through Epigenetic Modulation of Claudin-1 Gene Expression in Podocytes—Possible Existence of Renal Tubules-Podocytes Communication

Friday, October 26 | 5:00PM - 7:00PM
Aging and Cardiovascular Diseases
Room: Daigo

Speaker 6 of 6
Ken Shinmura, Keio University School of Medicine, Japan
Short Talk: Cardiac Sirt1 Is Essential for Caloric Restriction-Induced Cardioprotection against Ischemia/Reperfusion

Friday, October 26 | 7:00PM - 7:15PM
Closing Remarks
Room: Daigo

Speaker 1 of 1
Judith Campisi, Buck Institute for Research on Aging, USA

Friday, October 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer/Saga/Daigo


Saturday, October 27 | 10:25AM - 10:25AM
Departure


*Session Chair.