Web Desc
HIV Vaccines
joint with B Cell Development and Function
Organizer(s): Georgia D. Tomaras, Quentin J. Sattentau and Barbara L. Shacklett
Date: February 10 - 15, 2013
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Gilead Sciences, Inc. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation.
Summary of Meeting:
Recent data in both humans and non-human primates suggest that a clinically useful HIV-1 vaccine is possible and that the use of therapeutic interventions can be an efficacious prevention strategy. The path forward will require a detailed understanding of the correlates of protection to HIV-1/SIV and the development of better immunogens to induce specific and long lasting immunity. Moreover, the role of vaccine elicited immune responses to prevent the initial stages of HIV-1 infection at mucosal sites will be critical toward understanding protective immunity. Scientific expertise from vaccine trials and studies of long term immunity will help inform decisions in the path to the induction of immunity by an HIV-1 vaccine. Furthermore, a better understanding of how to target an efficacious vaccine in diverse populations will require more detailed studies of host genetics, innate immune responses, the effect of therapeutic interventions and other host factors (that can affect the development of robust immune responses and/or the analysis of HIV-1 vaccine trials. At this meeting, leading experts from both within and outside the HIV field will present findings from recent advances in human and non-human primate trials on immune mechanisms of protection as well as implementation of efficacious vaccines and other preventative strategies in diverse populations. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on B Cell Development and Function – which will share a keynote session and two plenary sessions with this meeting. This pairing is explicitly designed to enhance opportunities for exchanges between researchers who do not typically interact. In this regard, it must be emphasized that a major roadblock in our efforts to generate a successful HIV vaccine relates to our limited knowledge of the B cell subsets and signals required for the durable production of protective class-switched HIV-1 neutralizing and inhibitory antibodies systemically and at mucosal sites.
Global Health Travel Award Deadline: September 11 2012
Scholarship Deadline: October 10 2012
Discounted Abstract Deadline: October 10 2012
Abstract Deadline: November 12 2012
Discounted Registration Deadline: December 10 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates FoundationGilead Sciences, Inc.
We gratefully acknowledge additional support for this conference from:
Landes Bioscience
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI104364-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 10 | 3:00PM - 7:30PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, February 10 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Sunday, February 10 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 1 of 4
* Max D. Cooper, Emory University, USA

Sunday, February 10 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 2 of 4
* Georgia D. Tomaras, Duke University Medical Center, USA

Sunday, February 10 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 3 of 4
Myron S. Cohen, University of North Carolina at Chapel Hill, USA
HIV Prevention 2013: Preparing for a Vaccine

Sunday, February 10 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 4 of 4
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
The Human Antibody Response to HIV

Monday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Monday, February 11 | 8:00AM - 11:15AM
Protective Responses in Animal Models
Room: Quandary Peak

Speaker 1 of 7
* James A. Hoxie, University of Pennsylvania, USA

Monday, February 11 | 8:00AM - 11:15AM
Protective Responses in Animal Models
Room: Quandary Peak

Speaker 2 of 7
David H. O'Connor, University of Wisconsin-Madison, USA
Understanding SIV Control in Macaques with Restricted Genetic Diversity

Monday, February 11 | 8:00AM - 11:15AM
Protective Responses in Animal Models
Room: Quandary Peak

Speaker 3 of 7
Genoveffa Franchini, NCI, National Institutes of Health, USA
Innate and Adaptive Immune Correlate of Protection Against SIVmac251

Monday, February 11 | 8:00AM - 11:15AM
Protective Responses in Animal Models
Room: Quandary Peak

Speaker 4 of 7
Kevin O. Saunders, Duke University, USA
Short Talk: Lasting Protection Against SHIV by VRC01 Protein Immunoprophylaxis in Indian Rhesus Macaques

Monday, February 11 | 8:00AM - 11:15AM
Protective Responses in Animal Models
Room: Quandary Peak

Speaker 5 of 7
* Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Recent Developments in Non-human Primate Models for AIDS-related Vaccine Studies

Monday, February 11 | 8:00AM - 11:15AM
Protective Responses in Animal Models
Room: Quandary Peak

Speaker 6 of 7
Sallie R. Permar, Duke University Medical Center, USA
Immune Protection against Postnatal HIV-1/SIV Transmission

Monday, February 11 | 8:00AM - 11:15AM
Protective Responses in Animal Models
Room: Quandary Peak

Speaker 7 of 7
David B. Weiner, Wistar Institute, USA
Short Talk: Non-Human Primate Challenge Model to Study the Role of Serum and Vaginal IgA in Acquisition of Infection

Monday, February 11 | 8:00AM - 11:15AM
B Cell Genesis
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 6
* Max D. Cooper, Emory University, USA
Evolution of Adaptive Immunity in Vertebrates


Monday, February 11 | 8:00AM - 11:15AM
B Cell Genesis
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 6
Rudolf Grosschedl, Max Planck Institute of Immunobiology and Epigenetics, Germany
Mechanisms Underlying Transcriptional Control of B Cell Differentiation


Monday, February 11 | 8:00AM - 11:15AM
B Cell Genesis
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 6
Tasuku Honjo, Kyoto University Graduate School of Medicine, Japan
Acquired Immunity, Genome Instability, and Cancer


Monday, February 11 | 8:00AM - 11:15AM
B Cell Genesis
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 6
Frederick W. Alt, Boston Children's Hospital, USA
V(D)J Recombination, IgH Class Switch Recombination, and Genomic Instability


Monday, February 11 | 8:00AM - 11:15AM
B Cell Genesis
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 6
Bao Q. Vuong, City College of New York, CUNY, USA
Short Talk: A DNA Double Strand Break and Phosphorylation-Dependent Positive Feedback Loop Promotes Class Switch Recombination


Monday, February 11 | 8:00AM - 11:15AM
B Cell Genesis
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 6 of 6
Patricia J. Gearhart, NIA, National Institutes of Health, USA
Short Talk: Transcriptional Stalling of RNA Polymerase II Gives AID Access to Immunoglobulin Variable Genes


Monday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 11 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Monday, February 11 | 11:15AM - 12:45PM
Hands On Computer Workshop on Los Alamos Sequence Database a
nd Tools
Room: Castle Peaks
Maximum attendance: 60. Interested participants must sign up at the meeting on a first-come, first-serve basis.
Instructor: Brian Foley, Los Alamos National Laboratory

Monday, February 11 | 11:15AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Monday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Antibody Effector Functions and Env Based Immuno
gen Design
Room: Quandary Peak

Speaker 1 of 9
* George K. Lewis, University of Maryland, USA

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Antibody Effector Functions and Env Based Immuno
gen Design
Room: Quandary Peak

Speaker 2 of 9
* Mark Connors, NIAID, National Institutes of Health, USA

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Antibody Effector Functions and Env Based Immuno
gen Design
Room: Quandary Peak

Speaker 3 of 9
James E. Voss, The Scripps Research Institute, USA
SIV Vaccine Induces Local AntibodyProduction and Delivery Correlate with Protection in Female Reproductive Tract Protection.

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Antibody Effector Functions and Env Based Immuno
gen Design
Room: Quandary Peak

Speaker 4 of 9
Justin Pollara, Duke University, USA
Synergy between C1 Conformational and Anti-V2 Monoclonal Antibodies for Cell Surface Binding and ADCC

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Antibody Effector Functions and Env Based Immuno
gen Design
Room: Quandary Peak

Speaker 5 of 9
Chiara Orlandi, University of Maryland, USA
Potent ADCC Mediated by Human Monoclonal Antibodies (mAbs) Against Multiple Conserved Epitopes of HIV-Env


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Antibody Effector Functions and Env Based Immuno
gen Design
Room: Quandary Peak

Speaker 6 of 9
Ross W. Lindsay, Stemline Therapeutics, USA
An Inactivated Viral Vaccine that Displays Conformationally Intact HIV-1 Envelope Trimers Elicits Neutralizing Antibodies

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Antibody Effector Functions and Env Based Immuno
gen Design
Room: Quandary Peak

Speaker 7 of 9
Andrew McGuire, Fred Hutchinson Cancer Research Center, USA
Engaging of the Germline BCRs of Anti-HIV bNAbs with Modified Recombinant Env Immunogens

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Antibody Effector Functions and Env Based Immuno
gen Design
Room: Quandary Peak

Speaker 8 of 9
Andrew B. Ward, The Scripps Research Institute, USA
Evaluating HIV Envelope Trimers as Structural Scaffolds and Immunogens

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Antibody Effector Functions and Env Based Immuno
gen Design
Room: Quandary Peak

Speaker 9 of 9
Joseph R. Francica, Vaccine Research Center, National Institutes of Health, USA
Genetic Assessment of B Cell Responses in NHP following HIV Env Immunization

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: B Cell Development and Signaling
This session is from B Cells
Room: Longs/Gray Peaks

Speaker 1 of 8
* † David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: B Cell Development and Signaling
This session is from B Cells
Room: Longs/Gray Peaks

Speaker 2 of 8
Anupam Banerjee, University of Pennsylvania, USA
Transcriptional Repression of Gata3 Is Essential for Early B Cell Commitment


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: B Cell Development and Signaling
This session is from B Cells
Room: Longs/Gray Peaks

Speaker 3 of 8
Matteo Villa, MPI Immunobiology and Epigenetics, Germany
The Role of Aryl Hydrocarbon Receptor in B Cell-Mediated Immunity


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: B Cell Development and Signaling
This session is from B Cells
Room: Longs/Gray Peaks

Speaker 4 of 8
* Mary Ellen Conley, University of Tennessee College of Medicine, USA
A Dominant Negative Mutation in the Transcription Factor E2A in Patients with Agammaglobulinemia


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: B Cell Development and Signaling
This session is from B Cells
Room: Longs/Gray Peaks

Speaker 5 of 8
Stéphane J. C. Mancini, INSERM, France
The Development of the Pro-B and Pre-B Cell Subsets Depends on Distinct Bone Marrow Stromal Cell Niches


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: B Cell Development and Signaling
This session is from B Cells
Room: Longs/Gray Peaks

Speaker 6 of 8
Thomas Beck, Yale University, USA
Molecular Mechanisms of Developing B Cell Egress from the Bone Marrow


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: B Cell Development and Signaling
This session is from B Cells
Room: Longs/Gray Peaks

Speaker 7 of 8
Andre Limnander, Regeneron, USA
Unraveling the Molecular Mechanisms of Developmental Checkpoints during B Cell Selection in the Bone Marrow


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: B Cell Development and Signaling
This session is from B Cells
Room: Longs/Gray Peaks

Speaker 8 of 8
Marc Schwartz, Dana Farber Cancer Institute / Broad Institute, USA
The Role of CD40 in Peripheral B Cell Development


Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Molecular Basis of Antibody Diversification
This session is from B Cells
Room: Castle Peaks

Speaker 1 of 8
* Patrick C. Wilson, University of Chicago, USA


Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Molecular Basis of Antibody Diversification
This session is from B Cells
Room: Castle Peaks

Speaker 2 of 8
* George Georgiou, University of Texas at Austin, USA


Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Molecular Basis of Antibody Diversification
This session is from B Cells
Room: Castle Peaks

Speaker 3 of 8
Robert W. Maul, NIA, National Institutes of Health, USA
B Cell Receptor Stimulation Induces Uracil DNA Glycosylase and Inhibits Class Switch Recombination


Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Molecular Basis of Antibody Diversification
This session is from B Cells
Room: Castle Peaks

Speaker 4 of 8
Leng-Siew Yeap, Boston Children's Hospital, USA
Mechanisms by which DNA Sequences Influence Activation Induced Cytidine Deaminase (AID) Activity in Somatic Hypermutation and Class Switch Recombination


Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Molecular Basis of Antibody Diversification
This session is from B Cells
Room: Castle Peaks

Speaker 5 of 8
Jeroen E. Guikema, Academic Medical Center Amsterdam, Netherlands
Genome-Wide Analysis of RAG-Induced DNA Breaks in Developing B Cells


Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Molecular Basis of Antibody Diversification
This session is from B Cells
Room: Castle Peaks

Speaker 6 of 8
Stephen P. Methot, Institut de Recherches Cliniques de Montreal, Canada
Differentiating the Roles of Activation Induced Deaminase Cytoplasmic Retention and Nuclear Export


Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Molecular Basis of Antibody Diversification
This session is from B Cells
Room: Castle Peaks

Speaker 7 of 8
Menno C. van Zelm, Monash University, Australia
B Cell Antigen Receptor and CD40 Signaling Together Direct Human Antibody Maturation and Selection


Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Molecular Basis of Antibody Diversification
This session is from B Cells
Room: Castle Peaks

Speaker 8 of 8
Maria A. Curotto de Lafaille, New York University School of Medicine, USA
How the Failure-to-Thrive of IgE Germinal Centers Cells Paves the Way for the Unique Role of Sequential Switching in Generating IgE Plasma Cells


Monday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 11 | 5:00PM - 7:00PM
Potentially Protective Responses in Human Clinical Trials
Room: Quandary Peak

Speaker 1 of 6
* Georgia D. Tomaras, Duke University Medical Center, USA

Monday, February 11 | 5:00PM - 7:00PM
Potentially Protective Responses in Human Clinical Trials
Room: Quandary Peak

Speaker 2 of 6
* Lawrence Corey, Fred Hutchinson Cancer Research Center, USA

Monday, February 11 | 5:00PM - 7:00PM
Potentially Protective Responses in Human Clinical Trials
Room: Quandary Peak

Speaker 3 of 6
Merlin L. Robb, Walter Reed Army Institute of Research, USA
Military HIV Research Program Clinical Studies and the Search for Correlates

Monday, February 11 | 5:00PM - 7:00PM
Potentially Protective Responses in Human Clinical Trials
Room: Quandary Peak

Speaker 4 of 6
Glenda E. Gray, South African Medical Research Council, South Africa
Efficacy Trials in South Africa: Factors Affecting Vaccine Induced Immune Response in HIV Clinical Trials

Monday, February 11 | 5:00PM - 7:00PM
Potentially Protective Responses in Human Clinical Trials
Room: Quandary Peak

Speaker 5 of 6
Barney S. Graham, NIAID, National Institutes of Health, USA
Active and Passive Immunity Against HIV

Monday, February 11 | 5:00PM - 7:00PM
Potentially Protective Responses in Human Clinical Trials
Room: Quandary Peak

Speaker 6 of 6
Susan Zolla-Pazner, Icahn School of Medicine at Mount Sinai, USA
Short Talk: RV144-Induced V1V2 Antibodies Reactive with Multiple Subtypes Correlated with Decreased Risk of HIV-1 Infection

Monday, February 11 | 5:00PM - 7:15PM
Early Events in B Cell Activation
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 5
* Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA
Dynamic Imaging of Lymphocyte Activation - From Single Molecule to Living Tissue


Monday, February 11 | 5:00PM - 7:15PM
Early Events in B Cell Activation
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 5
Michael Reth, Albert-Ludwigs University Freiburg, Germany
Role of Protein Islands for the Activation of B Cells


Monday, February 11 | 5:00PM - 7:15PM
Early Events in B Cell Activation
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 5
Susan K. Pierce, NIAID, National Institutes of Health, USA
How B Cells Remember


Monday, February 11 | 5:00PM - 7:15PM
Early Events in B Cell Activation
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 5
Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Short Talk: Endocytosis and Recycling of Immune Complexes by Follicular Dendritic Cells Enhances B Cell Binding and Activation


Monday, February 11 | 5:00PM - 7:15PM
Early Events in B Cell Activation
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 5
Victor L.J. Tybulewicz, Francis Crick Institute, UK
Short Talk: The B Cell Antigen Receptor Transduces Signals from the BAFF Receptor Required for B Cell Survival


Monday, February 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom


Monday, February 11 | 7:30PM - 10:00PM
Poster Session 1
Room: Colorado Rockies Ballroom


Tuesday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Tuesday, February 12 | 8:00AM - 11:00AM
Quality of Immune Response (Immune Geography and Memory)
Room: Quandary Peak

Speaker 1 of 7
* Barbara L. Shacklett, University of California, Davis, USA

Tuesday, February 12 | 8:00AM - 11:00AM
Quality of Immune Response (Immune Geography and Memory)
Room: Quandary Peak

Speaker 2 of 7
* Daniel C. Douek, NIAID, National Institutes of Health, USA

Tuesday, February 12 | 8:00AM - 11:00AM
Quality of Immune Response (Immune Geography and Memory)
Room: Quandary Peak

Speaker 3 of 7
Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging Immune Cell Dynamics and Function

Tuesday, February 12 | 8:00AM - 11:00AM
Quality of Immune Response (Immune Geography and Memory)
Room: Quandary Peak

Speaker 4 of 7
Jacob D. Estes, Oregon Health and Science University, USA
Early Events following SIV Mucosal Challenge

Tuesday, February 12 | 8:00AM - 11:00AM
Quality of Immune Response (Immune Geography and Memory)
Room: Quandary Peak

Speaker 5 of 7
Shane Crotty, La Jolla Institute for Immunology, USA
Designing Vaccines: The Role of CD4 follicular T-helper Cells

Tuesday, February 12 | 8:00AM - 11:00AM
Quality of Immune Response (Immune Geography and Memory)
Room: Quandary Peak

Speaker 6 of 7
Mario Roederer, NIAID, National Institutes of Health, USA
Single Cell Transcriptomics: Measuring Quality and Quantity

Tuesday, February 12 | 8:00AM - 11:00AM
Quality of Immune Response (Immune Geography and Memory)
Room: Quandary Peak

Speaker 7 of 7
Qingsheng Li, University of Nebraska Center for Virology, USA
Short Talk: Distribution and Dissemination of Transmitted SIV Viruses in the Early Infection of Rhesus macaques via Anal/Rectal Route

Tuesday, February 12 | 8:00AM - 11:15AM
B Cell Evolution and Repertoire Selection
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 6
* Ana Cumano, Pasteur Institute, France
Lineage Commitment in Fetal Hematopoiesis


Tuesday, February 12 | 8:00AM - 11:15AM
B Cell Evolution and Repertoire Selection
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 6
Michael S. Neuberger, Medical Research Council, UK
The AID/APOBEC Family of DNA Deaminases: Balancing Immunity versus Cancer


Tuesday, February 12 | 8:00AM - 11:15AM
B Cell Evolution and Repertoire Selection
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 6
Garnett H. Kelsoe, Duke University and Medical Center, USA
Genetic Control of the First Tolerance Checkpoint in B Cells


Tuesday, February 12 | 8:00AM - 11:15AM
B Cell Evolution and Repertoire Selection
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 6
Hedda Wardemann, German Cancer Research Center, Germany
An Atlas of the Murine B Cell Repertoire: From Immunoglobulin Sequence to B Cell Differentiation State and Histo-Anatomical Localization


Tuesday, February 12 | 8:00AM - 11:15AM
B Cell Evolution and Repertoire Selection
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 6
Ziv Shulman, Weizmann Institute, Israel
Short Talk: T Follicular Helper Cell Dynamics in Germinal Centers


Tuesday, February 12 | 8:00AM - 11:15AM
B Cell Evolution and Repertoire Selection
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 6 of 6
Christopher D. C. Allen, University of California, San Francisco, USA
Short Talk: IgE-Expressing B Cells Are Restrained by an Intrinsic Cell Fate Predisposition


Tuesday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 12 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Tuesday, February 12 | 11:00AM - 12:30PM
Hands On Computer Workshop on Los Alamos Immunology Database
and Tools
Room: Castle Peaks
Maximum attendance: 60. Interested participants must sign up at the meeting on a first-come, first-serve basis.
Instructor: Brian Foley, Los Alamos National Laboratory

Tuesday, February 12 | 11:00AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Tuesday, February 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Tuesday, February 12 | 2:30PM - 4:30PM
Joint Workshop: B Cell Responses to Vaccines and HIV
Room: Longs/Grays Peaks

Speaker 1 of 10
* Leonidas Stamatatos, Fred Hutchinson Cancer Research Center, USA

Tuesday, February 12 | 2:30PM - 4:30PM
Joint Workshop: B Cell Responses to Vaccines and HIV
Room: Longs/Grays Peaks

Speaker 2 of 10
* Jonathan W. Yewdell, NIAID, National Institutes of Health, USA

Tuesday, February 12 | 2:30PM - 4:30PM
Joint Workshop: B Cell Responses to Vaccines and HIV
Room: Longs/Grays Peaks

Speaker 3 of 10
David Nemazee, The Scripps Research Institute, USA
Knock-In Mice Expressing Broadly Neutralizing HIV Antibodies b12 and 4E10

Tuesday, February 12 | 2:30PM - 4:30PM
Joint Workshop: B Cell Responses to Vaccines and HIV
Room: Longs/Grays Peaks

Speaker 4 of 10
Katherine Nicholas, Vanderbilt University Medical Center, USA
The Effect of Chronic HIV-1 Infection on pTFH Cells

Tuesday, February 12 | 2:30PM - 4:30PM
Joint Workshop: B Cell Responses to Vaccines and HIV
Room: Longs/Grays Peaks

Speaker 5 of 10
Josiane Chagnon-Choquet, Université de Montréal, Canada
Maintenance of Breg Capacity and Increased LT-alpha Expression by First Line MZ-Like B Cells Is Associated with Control of HIV Disease Progression

Tuesday, February 12 | 2:30PM - 4:30PM
Joint Workshop: B Cell Responses to Vaccines and HIV
Room: Longs/Grays Peaks

Speaker 6 of 10
Adam K. Wheatley, University of Melbourne, Australia
Prime-Boost Vaccination Against Influenza H5N1 Elicits the Expansion of Potentially Neutralizing H5/H1 Cross-Reactive Memory B Cells

Tuesday, February 12 | 2:30PM - 4:30PM
Joint Workshop: B Cell Responses to Vaccines and HIV
Room: Longs/Grays Peaks

Speaker 7 of 10
Hongyan Liao, University of Nebraska Medical Center, USA
Dominant Production of Polyreactive Antibodies by Circulating Plasmablasts in HIV-Infected Individuals

Tuesday, February 12 | 2:30PM - 4:30PM
Joint Workshop: B Cell Responses to Vaccines and HIV
Room: Longs/Grays Peaks

Speaker 8 of 10
Sarah F. Andrews, National Institutes of Health, USA
Adaptibility of the Human Influenza-specific Antibody Response

Tuesday, February 12 | 2:30PM - 4:30PM
Joint Workshop: B Cell Responses to Vaccines and HIV
Room: Longs/Grays Peaks

Speaker 9 of 10
Sean P. McBurney, Oregon Health Sciences University, USA
Elicitation of MPER-Specific Neutralizing Antibodies following Vaccination with an MPER-Targeted Vaccine Strategy

Tuesday, February 12 | 2:30PM - 4:30PM
Joint Workshop: B Cell Responses to Vaccines and HIV
Room: Longs/Grays Peaks

Speaker 10 of 10
John B. Schell, Yale School of Medicine, USA
An Env-Only Vaccine Does Not Provide Sterilizing Protection of Rhesus macaques
Against High-Dose SIVsmE660 Challenge


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Mucosal B Cell Responses
This session is from B Cells
Room: Quandary Peak

Speaker 1 of 6
* Sidonia Fagarasan, RIKEN Research Center for Allergy and Immunology, Japan


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Mucosal B Cell Responses
This session is from B Cells
Room: Quandary Peak

Speaker 2 of 6
Samuel K. Lai, University of North Carolina at Chapel Hill, USA
Mucosal Immunity Mediated by Antibody-Mucin Crosslinking


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Mucosal B Cell Responses
This session is from B Cells
Room: Quandary Peak

Speaker 3 of 6
Georg F. Weber, University Hospital Erlangen, Germany
Protective Function of Pleural B Cells in Pneumonia


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Mucosal B Cell Responses
This session is from B Cells
Room: Quandary Peak

Speaker 4 of 6
Mats Bemark, Gothenburg University, Sweden
Oral Immunization Induces Long-Lived Intestinal and Bone Marrow Plasma Cells and Memory B Cells Destined for Mucosal Homing


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Mucosal B Cell Responses
This session is from B Cells
Room: Quandary Peak

Speaker 5 of 6
Øyvind Steinsbø, Oslo University Hospital - Rikshospitalet, Norway
Limited Somatic Hypermutation in IgA of Transglutaminase 2 Specific as well as Gluten Specific Plasma Cells of Celiac Disease Intestinal Lesions


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Mucosal B Cell Responses
This session is from B Cells
Room: Quandary Peak

Speaker 6 of 6
Giuliana Magri, Institut Hospital del Mar d'Investigacions Médiques, Spain
A Novel Subset of GM-CSF-Producing Innate Lymphoid Cells Links Splenic B Cell-Helper Neutrophils with Marginal Zone B Cells


Tuesday, February 12 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 12 | 5:00PM - 7:15PM
Mucosal Antibody Responses (Joint)
Room: Columbine Ballroom

Speaker 1 of 6
* Barton F. Haynes, Duke University Medical Center, USA

Tuesday, February 12 | 5:00PM - 7:15PM
Mucosal Antibody Responses (Joint)
Room: Columbine Ballroom

Speaker 2 of 6
* Andrea Cerutti, Mount Sinai School of Medicine, USA
Mucus and Goblet Cells : New Insights in Intestinal Homeostasis Homeostasis

Tuesday, February 12 | 5:00PM - 7:15PM
Mucosal Antibody Responses (Joint)
Room: Columbine Ballroom

Speaker 3 of 6
Sidonia Fagarasan, RIKEN Research Center for Allergy and Immunology, Japan
IgA Synthesis: A Form of Functional Immune Adaptation Extending Beyond Gut

Tuesday, February 12 | 5:00PM - 7:15PM
Mucosal Antibody Responses (Joint)
Room: Columbine Ballroom

Speaker 4 of 6
Andrew J.S. Macpherson, University of Bern, Switzerland
Mucosal and Systemic Antibody Responses to Commensal Microbes – Induction and Function

Tuesday, February 12 | 5:00PM - 7:15PM
Mucosal Antibody Responses (Joint)
Room: Columbine Ballroom

Speaker 5 of 6
Duane R. Wesemann, Harvard Medical School, USA
Short Talk: Early B Lineage Cell Develompment in the Gut Lamina Propria

Tuesday, February 12 | 5:00PM - 7:15PM
Mucosal Antibody Responses (Joint)
Room: Columbine Ballroom

Speaker 6 of 6
Olga Malykhina, Northwestern University, USA
Short Talk: Cervical and Cervicovaginal Mucus Show Differential Retention of IgA But Similar Retention of IgG -- Implication for HIV Vaccine

Tuesday, February 12 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom


Tuesday, February 12 | 7:30PM - 10:00PM
Poster Session 2
Room: Colorado Rockies Ballroom


Wednesday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Wednesday, February 13 | 8:00AM - 11:15AM
CD8 and CD4 T Cell Immunity
Room: Quandary Peak

Speaker 1 of 8
* Douglas F. Nixon, Weill Cornell Medicine, USA

Wednesday, February 13 | 8:00AM - 11:15AM
CD8 and CD4 T Cell Immunity
Room: Quandary Peak

Speaker 2 of 8
* Stephen A. Migueles, NIAID, National Institutes of Health, USA

Wednesday, February 13 | 8:00AM - 11:15AM
CD8 and CD4 T Cell Immunity
Room: Quandary Peak

Speaker 3 of 8
Hendrik Streeck, US Military HIV Research Program, USA
HIV-Specific CD4 T-Cells

Wednesday, February 13 | 8:00AM - 11:15AM
CD8 and CD4 T Cell Immunity
Room: Quandary Peak

Speaker 4 of 8
Olivier Lambotte, University Paris South, France
T-cells in HIV Controllers and the Perspectives for HIV Cure Strategies

Wednesday, February 13 | 8:00AM - 11:15AM
CD8 and CD4 T Cell Immunity
Room: Quandary Peak

Speaker 5 of 8
Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Properties of Protective CD8 T Cell Responses

Wednesday, February 13 | 8:00AM - 11:15AM
CD8 and CD4 T Cell Immunity
Room: Quandary Peak

Speaker 6 of 8
Barbara L. Shacklett, University of California, Davis, USA
Mucosal T-Cell Responses and HIV Infection

Wednesday, February 13 | 8:00AM - 11:15AM
CD8 and CD4 T Cell Immunity
Room: Quandary Peak

Speaker 7 of 8
Brenna J. Hill, Frederick National Laboratories, USA
Short Talk: Characterization of SIV-Specific T Cells after Heterologous Mucosal Vaccination

Wednesday, February 13 | 8:00AM - 11:15AM
CD8 and CD4 T Cell Immunity
Room: Quandary Peak

Speaker 8 of 8
Tomas Hanke, University of Oxford, UK
Short Talk: Targeting HIV-1 Where It Hurts: Phase I/ IIa Clinical Trials

Wednesday, February 13 | 8:00AM - 11:15AM
Germinal Center, Plasma Cell and Memory B Cell Differentiati
on
This session is from B Cells

Room: Longs/Grays Peaks

Speaker 1 of 6
* Carola G. Vinuesa, Australian National University, Australia
Regulation of Tfh Cell-Mediated Selection in Germinal Centers


Wednesday, February 13 | 8:00AM - 11:15AM
Germinal Center, Plasma Cell and Memory B Cell Differentiati
on
This session is from B Cells

Room: Longs/Grays Peaks

Speaker 2 of 6
Jason G. Cyster, HHMI/University of California, San Francisco, USA
Lipid Cues and Cell Migration during the Humoral Immune Response


Wednesday, February 13 | 8:00AM - 11:15AM
Germinal Center, Plasma Cell and Memory B Cell Differentiati
on
This session is from B Cells

Room: Longs/Grays Peaks

Speaker 3 of 6
Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Dendritic Cells and Macrophages Help the Generation of Human Plasma Cells


Wednesday, February 13 | 8:00AM - 11:15AM
Germinal Center, Plasma Cell and Memory B Cell Differentiati
on
This session is from B Cells

Room: Longs/Grays Peaks

Speaker 4 of 6
Tomohiro Kurosaki, Osaka University, Japan
B Cell Intrinsic and Extrinsic Mechanisms for Rapid Responsiveness of IgG1 Type Memory B Cells


Wednesday, February 13 | 8:00AM - 11:15AM
Germinal Center, Plasma Cell and Memory B Cell Differentiati
on
This session is from B Cells

Room: Longs/Grays Peaks

Speaker 5 of 6
Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Short Talk: Clonal Anergy, the Function of IgD, and Redemption of Self-Reactive Antibodies in Germinal Centers


Wednesday, February 13 | 8:00AM - 11:15AM
Germinal Center, Plasma Cell and Memory B Cell Differentiati
on
This session is from B Cells

Room: Longs/Grays Peaks

Speaker 6 of 6
Hai Qi, Tsinghua University, China
Short Talk: Parenchymal Bystander B Cells Control ICOS-Dependent Follicular Recruitment of Helper T Cells


Wednesday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 13 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, February 13 | 11:15AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Wednesday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: Germinal Center B Cell Response
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 9
* Ulf Klein, Columbia University, USA


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: Germinal Center B Cell Response
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 9
Alexander Dent, Indiana University School of Medicine, USA
Dissecting the Role of BCL6 in Normal B Cells


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: Germinal Center B Cell Response
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 9
Lisa G. Barnett, Genomics Institute of the Novartis Research Foundation, USA
Temporally Defined Cognate T Cell-B Cell Interactions Regulate Germinal Center Development


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: Germinal Center B Cell Response
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 9
Gabriel D. Victora, Rockefeller University, USA
c-MYC Is Required for Germinal Center Selection and Cyclic Re-Entry


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: Germinal Center B Cell Response
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 9
Zahra Sabouri, Australian National University, Australia
Antibody Redemption: Removal of Self-Reactivity from IgD+ Anergic B Cells by Purifying Selection in Germinal Centers


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: Germinal Center B Cell Response
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 6 of 9
Kai-Michael Toellner, University of Birmingham, UK
Asymmetric B Cell Division Optimises Information Processing in Germinal Centres


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: Germinal Center B Cell Response
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 7 of 9
* Carol E. Schrader, University of Massachusetts, USA
AP Endonuclease 2 (APE2) Regulates the
Expansion of Germinal Center B Cells by Protecting Against Oxidative Damage


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: Germinal Center B Cell Response
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 8 of 9
Alberto Martin, University of Toronto, Canada
Caspase 8 Activity Regulates Germinal Center B Cell Homeostasis and the Generation of High Affinity Antibodies


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: Germinal Center B Cell Response
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 9 of 9
Luise Humpert, Roche, Switzerland
Functional Role of CXCR7 Expression on Late Germinal Center B Cells


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Plasma Cell and Memory B Cell Responses
This session is from B Cells
Room: Castle Peaks

Speaker 1 of 9
* John C. Cambier, University of Colorado, USA


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Plasma Cell and Memory B Cell Responses
This session is from B Cells
Room: Castle Peaks

Speaker 2 of 9
Wei Xu, Roche Innovation Center Zurich, Switzerland
Identification of Human Granzyme B-Expressing Plasma Cells


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Plasma Cell and Memory B Cell Responses
This session is from B Cells
Room: Castle Peaks

Speaker 3 of 9
Ignacio Sanz, Emory University, School of Medicine, USA
Heterogeneity of Antibody Secreting Cell Subsets in Blood after Vaccination and Bone Marrow in Healthy Adults: Identification of Human Long-Lived Plasma Cells


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Plasma Cell and Memory B Cell Responses
This session is from B Cells
Room: Castle Peaks

Speaker 4 of 9
Laura Ann George, University of Birmingham, UK
Differential Regulation of IRF4 during Extrafollicular B Cell Differentiation, and its Role for Ig Class Switching


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Plasma Cell and Memory B Cell Responses
This session is from B Cells
Room: Castle Peaks

Speaker 5 of 9
Mark Wright, Monash University, Australia
Plasma Cells Require CD37-Dependent Integrin Signaling for Long-Term Survival


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Plasma Cell and Memory B Cell Responses
This session is from B Cells
Room: Castle Peaks

Speaker 6 of 9
* Lynn M. Corcoran, Walter and Eliza Hall Institute of Medical Research, Australia
The BTB-ZF Transcription Factor Zbtb20 Is Driven by Irf4 and Promotes Plasma Cell Differentiation


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Plasma Cell and Memory B Cell Responses
This session is from B Cells
Room: Castle Peaks

Speaker 7 of 9
Deepta Bhattacharya, Washington University School of Medicine, USA
Adjuvant-Specific Regulation of Long-Term Antibody Responses by Zbtb20


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Plasma Cell and Memory B Cell Responses
This session is from B Cells
Room: Castle Peaks

Speaker 8 of 9
Daniel Radtke, University of Erlangen, Germany
Grb2 Regulates B Cell Maturation, B Cell Memory Responses and Inhibits B Cell Ca2+ Signaling


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Plasma Cell and Memory B Cell Responses
This session is from B Cells
Room: Castle Peaks

Speaker 9 of 9
Boaz Tirosh, Hebrew University, Israel
mTORC1 Activation Promotes Plasma Cell Differentiation and Bypasses the Unfolded Protein Response for Immunoglobulin Secretion


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 7: Autoimmunity and Neoplasia
This session is from B Cells
Room: Quandary Peak

Speaker 1 of 9
* Ann Marshak-Rothstein, University of Massachusetts Medical School, USA


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 7: Autoimmunity and Neoplasia
This session is from B Cells
Room: Quandary Peak

Speaker 2 of 9
* Michael P. Cancro, University of Pennsylvania, USA


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 7: Autoimmunity and Neoplasia
This session is from B Cells
Room: Quandary Peak

Speaker 3 of 9
Joseph D. Dekker, University of Texas at Austin, USA
Pathways and Mechanisms by which FOXP1 and BCL11A Contribute to Activated B Cell Diffuse Large B Cell Lymphoma (ABC-DLBCL)


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 7: Autoimmunity and Neoplasia
This session is from B Cells
Room: Quandary Peak

Speaker 4 of 9
Carel J. M. van Noesel, Academic Medical Center, Netherlands
Antigen-Driven Lymphoma Growth: A Novel Mutated B-Cell Chronic Lymphocytic Leukemia Subset that Recognizes and Responds to Fungi


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 7: Autoimmunity and Neoplasia
This session is from B Cells
Room: Quandary Peak

Speaker 5 of 9
Saravanan Yuvaraj, Erasmus Medical Centrum, Netherlands
The Role of Antigenic Stimulation in the Pathogenesis of Chronic Lymphocytic Leukemia


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 7: Autoimmunity and Neoplasia
This session is from B Cells
Room: Quandary Peak

Speaker 6 of 9
Simone Bürgler, Rikshospitalet and University of Oslo, Norway
A Chronic Immune Response between B Cells and T Helper Cells Drives Chronic Lymphocytic Leukemia


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 7: Autoimmunity and Neoplasia
This session is from B Cells
Room: Quandary Peak

Speaker 7 of 9
Nataliya Yeremenko, Academic Medical Center, Netherlands
The Role of Bob1 in Rheumatoid Arthritis: Potential Implications for Autoimmunity


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 7: Autoimmunity and Neoplasia
This session is from B Cells
Room: Quandary Peak

Speaker 8 of 9
Simanta Pathak, University of Texas Southwestern Medical Center, USA
Overexpression of Fatty Acid Amide Hydrolase Promotes Peripheral B Cell Receptor Revision and Emergence of Polyreactive Antibodies in Lupus Prone Mice


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 7: Autoimmunity and Neoplasia
This session is from B Cells
Room: Quandary Peak

Speaker 9 of 9
Nancy L. Monson, University of Texas Southwestern Medical Center, USA
B Cells that Display a Particular Somatic Hypermutation Pattern in their Antibody Genes Are Unique to Patients with Multiple Sclerosis and Recognize Neurons and Astrocytes


Wednesday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 13 | 5:00PM - 7:00PM
Protective Antibody Responses Against HIV (Joint)
Room: Columbine Ballroom

Speaker 1 of 6
* Christiane Moog, INSERM and Université of Strasbourg, France

Wednesday, February 13 | 5:00PM - 7:00PM
Protective Antibody Responses Against HIV (Joint)
Room: Columbine Ballroom

Speaker 2 of 6
* Diane L. Bolton, US Military HIV Research Program, USA

Wednesday, February 13 | 5:00PM - 7:00PM
Protective Antibody Responses Against HIV (Joint)
Room: Columbine Ballroom

Speaker 3 of 6
Barton F. Haynes, Duke University Medical Center, USA
Antibody Virus Co-evolution in Acutely Infected Patients Followed to Broadly Neutralizing Antibody Induction

Wednesday, February 13 | 5:00PM - 7:00PM
Protective Antibody Responses Against HIV (Joint)
Room: Columbine Ballroom

Speaker 4 of 6
Peter D. Kwong, NIAID, National Institutes of Health, USA
Structural Biology of Sites of HIV-1 Vulnerability to Neutralizing Antibody

Wednesday, February 13 | 5:00PM - 7:00PM
Protective Antibody Responses Against HIV (Joint)
Room: Columbine Ballroom

Speaker 5 of 6
Dennis R. Burton, The Scripps Research Institute, USA
Antibody Protection Against HIV: Broadly Neutralizing MAb PGT121

Wednesday, February 13 | 5:00PM - 7:00PM
Protective Antibody Responses Against HIV (Joint)
Room: Columbine Ballroom

Speaker 6 of 6
Georgia D. Tomaras, Duke University Medical Center, USA
Spectrum of Vaccine-Elicited Humoral Responses

Wednesday, February 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom


Wednesday, February 13 | 7:30PM - 10:00PM
Poster Session 3
Room: Colorado Rockies Ballroom


Thursday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Thursday, February 14 | 8:00AM - 11:00AM
New Concepts in Innate Immunity and Stimulation
Room: Quandary Peak

Speaker 1 of 7
* Robert A. Seder, NIAID, National Institutes of Health, USA

Thursday, February 14 | 8:00AM - 11:00AM
New Concepts in Innate Immunity and Stimulation
Room: Quandary Peak

Speaker 2 of 7
* Gregg A. Dean, Colorado State University, USA

Thursday, February 14 | 8:00AM - 11:00AM
New Concepts in Innate Immunity and Stimulation
Room: Quandary Peak

Speaker 3 of 7
Peter Johannes Holst, BioInnovation Institute, Denmark
Short Talk: MHC Class II Associated Invariant Chain as a Genetic Adjuvant in Virus Vectored Vaccines

Thursday, February 14 | 8:00AM - 11:00AM
New Concepts in Innate Immunity and Stimulation
Room: Quandary Peak

Speaker 4 of 7
Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA
HIV-DC interactions

Thursday, February 14 | 8:00AM - 11:00AM
New Concepts in Innate Immunity and Stimulation
Room: Quandary Peak

Speaker 5 of 7
Persephone Borrow, University of Oxford, UK
Innate Immune Pressure on Transmitted HIV-1

Thursday, February 14 | 8:00AM - 11:00AM
New Concepts in Innate Immunity and Stimulation
Room: Quandary Peak

Speaker 6 of 7
Karin Loré, Karolinska Institutet, Sweden
Innate mechanisms by which Vaccine Adjuvants Influence HIV Env Immunity in Non-Human Primates

Thursday, February 14 | 8:00AM - 11:00AM
New Concepts in Innate Immunity and Stimulation
Room: Quandary Peak

Speaker 7 of 7
Xu Yu, Massachusetts General Hospital, USA
Short Talk: LILRB2 Interaction with HLA Class I Correlates with Outcomes of HIV-1 Infection

Thursday, February 14 | 8:00AM - 11:00AM
MicroRNAs and B Cell Neoplasias
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 4
* Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
MicroRNAs in Normal and Neoplastic B Cells


Thursday, February 14 | 8:00AM - 11:00AM
MicroRNAs and B Cell Neoplasias
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 4
Maryaline Coffre, New York University School of Medicine, USA
Short Talk: Role of RNAi in B Cell Development and Maturation


Thursday, February 14 | 8:00AM - 11:00AM
MicroRNAs and B Cell Neoplasias
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 4
Louis M. Staudt, NCI, National Institutes of Health, USA
Therapeutic Efficacy of B Cell Receptor Signaling Inhibitors in Lymphoma


Thursday, February 14 | 8:00AM - 11:00AM
MicroRNAs and B Cell Neoplasias
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 4
David Baltimore, California Institute of Technology, USA
MicroRNAs, Inflammation and Cancer


Thursday, February 14 | 9:00AM - 9:20AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 14 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, February 14 | 2:30PM - 4:30PM
Workshop 3: CD4+ T Cell Help
Room: Quandary Peak

Speaker 1 of 8
* Nicole Frahm, Bill & Melinda Gates Medical Research Institute, USA

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 3: CD4+ T Cell Help
Room: Quandary Peak

Speaker 2 of 8
* Spyros A. Kalams, Vanderbilt University Medical Center, USA

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 3: CD4+ T Cell Help
Room: Quandary Peak

Speaker 3 of 8
Kristin L. Boswell, NIAID, National Institutes of Health, USA
Characterization of Peripheral TFH-like Cells in HIV Infection

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 3: CD4+ T Cell Help
Room: Quandary Peak

Speaker 4 of 8
Rafael Cubas, Genentech, USA
Impaired Peripheral Tfh-mediated B-cell Function Affects Humoral Defenses in Chronic HIV Infected Individuals

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 3: CD4+ T Cell Help
Room: Quandary Peak

Speaker 5 of 8
Colin Havenar-Daughton, Vir Biotechnology, USA
Ability to Generate HIV-1 Neutralizing Antibodies Is Correlated with Increases in Activated Memory B Cells and Peripheral T Follicular Helper Cells

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 3: CD4+ T Cell Help
Room: Quandary Peak

Speaker 6 of 8
Antje Heit, Fred Hutchinson Cancer Research Center, USA
HVTN-Tested Candidate HIV Vaccines Induce Early Plasmablast and Tfh-Like Responses in Peripheral Blood

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 3: CD4+ T Cell Help
Room: Quandary Peak

Speaker 7 of 8
Kristin Hollister, Indiana University School of Medicine, USA
Enhanced Expansion of Follicular T Helper Cells following Vaccination with gp120-Encoding DNA

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 3: CD4+ T Cell Help
Room: Quandary Peak

Speaker 8 of 8
Patricia Bourguignon, GlaxoSmithKline Vaccines, Belgium
Co-Administration of an Adjuvanted HIV-1 Gag-Pol-Nef Fusion Protein (F4/AS01) and Adenovirus-35 Gag-RT-Int-Nef (Ad35-GRIN) Induces Potent, Polyfunctional CD4 and CD8 T-Cell Responses

Thursday, February 14 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 14 | 5:00PM - 7:00PM
Antibody Genomics and Immunogen Design
Room: Quandary Peak

Speaker 1 of 7
* Marie Pancera, Fred Hutchinson Cancer Research Center, USA

Thursday, February 14 | 5:00PM - 7:00PM
Antibody Genomics and Immunogen Design
Room: Quandary Peak

Speaker 2 of 7
John R. Mascola, NIAID, National Institutes of Health, USA
Genetics of Antibody Elicitation

Thursday, February 14 | 5:00PM - 7:00PM
Antibody Genomics and Immunogen Design
Room: Quandary Peak

Speaker 3 of 7
Ruth M. Ruprecht, Texas Biomedical Research Institute, USA
Passive Immunization against Mucosal R5 SHIV Transmission with Different Isotypes of Human Neutralizing Monoclonal Antibodies

Thursday, February 14 | 5:00PM - 7:00PM
Antibody Genomics and Immunogen Design
Room: Quandary Peak

Speaker 4 of 7
Nicole A. Doria-Rose, NIAID, National Institutes of Health, USA
Short Talk: Highly Potent V2-Directed Antibodies with Exceptionally Long CDRH3 that Neutralize HIV-1 Subtype C Viruses

Thursday, February 14 | 5:00PM - 7:00PM
Antibody Genomics and Immunogen Design
Room: Quandary Peak

Speaker 5 of 7
Rebecca M. Lynch, George Washington University, USA
Short Talk: Effective HIV-1 Neutralization at the CD4-Binding Site through Loop-Based Modes of Antibody Recognition

Thursday, February 14 | 5:00PM - 7:00PM
Antibody Genomics and Immunogen Design
Room: Quandary Peak

Speaker 6 of 7
William Schief, International AIDS Vaccine Initiative and The Scripps Research Institute, USA
Epitope-Focused HIV Vaccine Design

Thursday, February 14 | 5:00PM - 7:00PM
Antibody Genomics and Immunogen Design
Room: Quandary Peak

Speaker 7 of 7
* Quentin J. Sattentau, Sir William Dunn School of Pathology, UK
Chemical Modification of Env for HIV-1 Vaccine Design

Thursday, February 14 | 5:00PM - 7:00PM
Autoimmunity and Regulatory B Cells
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 4
* Betty Diamond, Feinstein Institute for Medical Research, USA
Negative Regulation of Peripheral Autoreactive B Cells


Thursday, February 14 | 5:00PM - 7:00PM
Autoimmunity and Regulatory B Cells
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 4
Robert Brink, Garvan Institute of Medical Research, Australia
Censoring Self-Reactive B Cells in the Germinal Center Reaction


Thursday, February 14 | 5:00PM - 7:00PM
Autoimmunity and Regulatory B Cells
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 4
Edgar G. Engleman, Stanford University School of Medicine, USA
B Cells and Insulin Resistance


Thursday, February 14 | 5:00PM - 7:00PM
Autoimmunity and Regulatory B Cells
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 4
Claude-Agnès Reynaud, Necker-Paris Medical School, France
Short Talk: B-Cell Depletion in Immune Thrombocytopenia Induces the Settlement of Splenic Long-Lived Plasma Cells


Thursday, February 14 | 7:15PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom


Thursday, February 14 | 8:00PM - 11:00PM
Entertainment
Room: Colorado Rockies Ballroom


Thursday, February 14 | 8:00PM - 11:00PM
Cash Bar
Room: Colorado Rockies Ballroom


Friday, February 15 | 10:25AM - 10:25AM
Departure


*Session Chair.