Web Desc
PI 3-Kinase and Interplay with Other Signaling Pathways
joint with Tumor Metabolism
Organizer(s): Christian Rommel, Kevan M. Shokat and José Baselga
Date: February 24 - March 01, 2013
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Bayer USA Foundation, Gilead Sciences, Inc., Infinity Pharmaceuticals and Pfizer Inc.
Summary of Meeting:
How metabolic pathways are regulated to meet the unique needs of tumor cells is not well understood, but mounting evidence suggests that metabolic regulation in cancer cells is intimately linked with the signal transduction pathways that control cell growth and proliferation. The PI3K-Akt-mTOR signaling pathway is one of the primary mechanisms for controlling tumor cell growth, survival, and motility in response to oncogenic signaling and extracellular cues. Genetic events resulting in inappropriate activation of this pathway are common in many cancers and, as a result, are a focus of both basic cancer research and drug discovery efforts in oncology. Although originally modeled as an independent and linear signaling cascade, today it is evident that the PI3K pathway also functions as a central hub for cross-talk in both vertical as well as reciprocal feedback regulation with other important signaling pathways. One of the most exciting advances in the field is the development of new inhibitors against this pathway. However, the rationale for inhibiting individual or multiple isoforms of PI3K/Akt/mTOR signaling remains a subject of intense debate. This meeting aims to bring together scientists and clinicians from academia and industry to discuss the opportunities and liabilities of targeting the PI3K- and related pathways in disease, drawing on human pathophysiology and genetics, preclinical models and clinical data with PI3K pathway inhibitors. A joint meeting addressing Tumor Metabolism will enhance opportunities for interdisciplinary interactions.
Scholarship Deadline: October 25 2012
Discounted Abstract Deadline: October 25 2012
Abstract Deadline: November 28 2012
Discounted Registration Deadline: December 19 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer USA FoundationGilead Sciences, Inc.Infinity PharmaceuticalsPfizer Inc.
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Echelon Biosciences, Inc.ROCKLAND IMMUNOCHEMICALS, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA174220-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 24 | 3:00PM - 7:30PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, February 24 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Sunday, February 24 | 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Grays Peak

Speaker 1 of 4
* Kevan M. Shokat, University of California, San Francisco, USA

Sunday, February 24 | 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Grays Peak

Speaker 2 of 4
* José Baselga, Memorial Sloan-Kettering Cancer Center, USA

Sunday, February 24 | 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Grays Peak

Speaker 3 of 4
* Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland

Sunday, February 24 | 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Grays Peak

Speaker 4 of 4
Roger L. Williams, Medical Research Council, UK
Tuning Locomotions in the PI3K Pathway

Monday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Monday, February 25 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical - Part 1)
Room: Grays Peak

Speaker 1 of 5
* José Baselga, Memorial Sloan-Kettering Cancer Center, USA
Breast Cancer

Monday, February 25 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical - Part 1)
Room: Grays Peak

Speaker 2 of 5
Brett S. Carver, USA
Targeting the PI3K and AR Pathways in Prostate Cancer: Defining Mechanisms of Response and Resistance

Monday, February 25 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical - Part 1)
Room: Grays Peak

Speaker 3 of 5
Vito J. Palombella, USA
Development of the Potent PI3K-delta,gamma Inhibitor IPI-145

Monday, February 25 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical - Part 1)
Room: Grays Peak

Speaker 4 of 5
Khaled Ali, Barts Cancer Institute, UK
Short Talk: Inactivation of p110delta PI 3-Kinase Releases Anti-Tumor Immune Responses

Monday, February 25 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical - Part 1)
Room: Grays Peak

Speaker 5 of 5
Kyle A. Edgar, Genentech, Inc., USA
Short Talk: Mechanisms of Acquired Resistance to the PI3K Inhibitor, GDC-0941 in Colorectal Cancer Cell Lines

Monday, February 25 | 9:00AM - 11:00AM
Metabolic Regulation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 1 of 5
* Karen H. Vousden, Francis Crick Institute, UK


Monday, February 25 | 9:00AM - 11:00AM
Metabolic Regulation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 2 of 5
Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany
The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells


Monday, February 25 | 9:00AM - 11:00AM
Metabolic Regulation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 3 of 5
Linda Z. Penn, Princess Margaret Cancer Centre, Canada
The Mevalonate Pathway, Signaling and Tumor Vulnerability


Monday, February 25 | 9:00AM - 11:00AM
Metabolic Regulation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 4 of 5
Daniel S. Peeper, Netherlands Cancer Institute, Netherlands
Short Talk: A Critical Role for the Mitochondrial Gatekeeper Pyruvate Dehydrogenase in Oncogene-Induced Senescence


Monday, February 25 | 9:00AM - 11:00AM
Metabolic Regulation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 5 of 5
Jing Chen, Winship Cancer Institute, Emory University, USA
Short Talk: Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth


Monday, February 25 | 9:20AM - 9:50AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 25 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Monday, February 25 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Monday, February 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 1 of 7
* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 2 of 7
Ji Zhang, Indiana University, USA
Why Cancer Cells Die without Glutamine?


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 3 of 7
Brandon N. Nicolay, Agios Pharmaceuticals, USA
Loss of RBF1 Changes Glutamine Catabolism


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 4 of 7
Ming Yang, Beatson Institute for Cancer Research, UK
Candidate Roles for Protein Succination in Altered Metabolism and Oncogenesis


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 5 of 7
Talya L. Dayton, Massachusetts Institute of Technology, USA
Elucidating a Role for Pkm Isoform Expression Specificity in vivo


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 6 of 7
Darin Salloum, Memorial Sloan Kettering Cancer Center, USA
Human Cancer Cells Harboring Ras Mutations Display Elevated Requirement for Serum Lipids


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 7 of 7
Wei Liu, Frederick National Laboratory for Cancer Research, National Institutes of Health, USA
Proline Biosynthesis Augments MYC-Induced Aerobic Glycolysis and Cell Growth


Monday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 25 | 5:00PM - 7:00PM
PI3K/Akt/mTOR Pathway (Clinical - Part 2)
Room: Grays Peak

Speaker 1 of 4
Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA
Interplay Signaling

Monday, February 25 | 5:00PM - 7:00PM
PI3K/Akt/mTOR Pathway (Clinical - Part 2)
Room: Grays Peak

Speaker 2 of 4
Kui Lin, Genentech, Inc., USA
Akt

Monday, February 25 | 5:00PM - 7:00PM
PI3K/Akt/mTOR Pathway (Clinical - Part 2)
Room: Grays Peak

Speaker 3 of 4
Mark G. Manfredi, Raze Therapeutics, USA
The Development of MLN0128, an Investigational mTOR Active Site Inhibitor

Monday, February 25 | 5:00PM - 7:00PM
PI3K/Akt/mTOR Pathway (Clinical - Part 2)
Room: Grays Peak

Speaker 4 of 4
Kathryn Balmanno, Babraham Institute, UK
Short Talk: Modelling Acquired Resistance to mTOR Kinase Inhibitors

Monday, February 25 | 5:00PM - 7:00PM
Nutrient Sensing
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 1 of 5
* Joan S. Brugge, Harvard Medical School, USA


Monday, February 25 | 5:00PM - 7:00PM
Nutrient Sensing
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 2 of 5
Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Autophagy Maintains Mitochondrial Function and Tumorigenesis


Monday, February 25 | 5:00PM - 7:00PM
Nutrient Sensing
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 3 of 5
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Metabolic Pathways Important for Cell Growth


Monday, February 25 | 5:00PM - 7:00PM
Nutrient Sensing
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 4 of 5
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Large-Scale Approaches to Study Cancer Metabolism


Monday, February 25 | 5:00PM - 7:00PM
Nutrient Sensing
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 5 of 5
Issam Ben-Sahra, Northwestern University, USA
Short Talk: Growth Signaling Stimulates Nucleotide Synthesis through mTOR


Monday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Monday, February 25 | 7:30PM - 10:00PM
Poster Session 1
Room: Quandary Peak


Tuesday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Tuesday, February 26 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
Room: Grays Peak

Speaker 1 of 6
* Jeffrey A. Engelman, Novartis Institutes for BioMedical Research, USA
Resistance Mechanisms

Tuesday, February 26 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
Room: Grays Peak

Speaker 2 of 6
Sebastian M. B. Nijman, CeMM, Austrian Academy of Sciences, Austria
Gene-Drug Interaction Screens in Cancer

Tuesday, February 26 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
Room: Grays Peak

Speaker 3 of 6
* Lori Friedman, ORIC Pharmaceuticals, USA
PI3K Inhibitor Combination Therapies

Tuesday, February 26 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
Room: Grays Peak

Speaker 4 of 6
Jonathan M. Backer, Albert Einstein College of Medicine, USA
GPCR–Mediated Activation of p110beta by Gbetagamma Is Required for Cellular Transformation and Invasiveness

Tuesday, February 26 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
Room: Grays Peak

Speaker 5 of 6
Wayne A. Phillips, Peter MacCallum Cancer Centre, Australia
Short Talk: Ubiquitous Expression of a Heterozygous Pik3ca Mutation Results in Increased Body Size, Hypoglycemia and Sudden Death

Tuesday, February 26 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
Room: Grays Peak

Speaker 6 of 6
Mamatha Bhat, University Health Network, Canada
Short Talk: Metformin Induces Apoptosis of Hepatocellular Carcinoma Downstream of mTORC1 through eIF4E

Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 1 of 7
* David M. Sabatini, Whitehead Institute for Biomedical Research, USA


Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 2 of 7
Brian J. Altman, University of Rochester, USA
Regulation of Cell Growth and Metabolism by Myc


Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 3 of 7
Karen H. Vousden, Francis Crick Institute, UK
The Role of p53 in Metabolic Adaptation and Survival


Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 4 of 7
Zachary Schug, Wistar Institute, USA
Targeting Lipid Metabolism in Breast Cancer


Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 5 of 7
Reuben J. Shaw, The Salk Institute for Biological Studies, USA
The LKB1 Tumor Suppressor Pathway: Decoding Metabolic Links and Therapeutic Targeting


Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 6 of 7
Costas A. Lyssiotis, University of Michigan, USA
Short Talk: Glutamine Metabolism Supports Pancreatic Tumor Growth and Redox Homeostasis


Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 7 of 7
Zhimin Lu, University of Texas MD Anderson Cancer Center, USA
Short Talk: The Warburg Effect and Beyond


Tuesday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 26 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Tuesday, February 26 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Tuesday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Tuesday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 26 | 5:00PM - 7:00PM
PI3K/mTOR Pathway - Signaling Networks (Preclinical)
Room: Grays Peak

Speaker 1 of 4
* Kevan M. Shokat, University of California, San Francisco, USA
Chemical Genetic Investigations of Protein and Lipid Kinase Signaling

Tuesday, February 26 | 5:00PM - 7:00PM
PI3K/mTOR Pathway - Signaling Networks (Preclinical)
Room: Grays Peak

Speaker 2 of 4
John Blenis, Weill Cornell Medical College, USA
Convergence and Integration of mTOR and Ras-ERK Signaling in Cancer

Tuesday, February 26 | 5:00PM - 7:00PM
PI3K/mTOR Pathway - Signaling Networks (Preclinical)
Room: Grays Peak

Speaker 3 of 4
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Regulation of Growth by the mTOR Pathway

Tuesday, February 26 | 5:00PM - 7:00PM
PI3K/mTOR Pathway - Signaling Networks (Preclinical)
Room: Grays Peak

Speaker 4 of 4
Tamara Chessa, Babraham Institute, UK
Short Talk: Dissecting the ClassIA PI3K Signalosome

Tuesday, February 26 | 5:00PM - 7:00PM
Understanding the Metabolic Network
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 1 of 5
* Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA


Tuesday, February 26 | 5:00PM - 7:00PM
Understanding the Metabolic Network
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 2 of 5
Tomer Shlomi, Technion, Israel
An Integrated Computational-Experimental Approach for Finding Metabolic Synthetic Lethality in Cancer


Tuesday, February 26 | 5:00PM - 7:00PM
Understanding the Metabolic Network
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 3 of 5
Joshua D. Rabinowitz, Princeton University, USA
Revealing Cancer Metabolism with Isotope Tracers


Tuesday, February 26 | 5:00PM - 7:00PM
Understanding the Metabolic Network
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 4 of 5
Linda C. Hsieh-Wilson, California Institute of Technology, USA
Linking O-GlcNAc Signaling to Cancer Metabolism and Tumor Growth


Tuesday, February 26 | 5:00PM - 7:00PM
Understanding the Metabolic Network
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 5 of 5
Stefan Kempa, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Quantifying Metabolic Routes in Cancer Cells Using Pulsed Stable Isotope Resolved Metabolomics (pSIRM)


Tuesday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Tuesday, February 26 | 7:30PM - 10:00PM
Poster Session 2
Room: Quandary Peak


Wednesday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Wednesday, February 27 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 1 of 6
* Lewis C. Cantley, Weill Cornell Medicine, USA
PI 3-Kinase, AMPK and Disease

Wednesday, February 27 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 2 of 6
Judith A. Varner, University of California, San Diego, USA
PI3K gamma Control of Innate Immunity in Cancer

Wednesday, February 27 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 3 of 6
Karen M. Cichowski, Brigham and Women's Hospital, Harvard Medical School, USA
Developing Combination Therapies with PI3K/mTOR Pathway Inhibitors

Wednesday, February 27 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 4 of 6
Hong Wu, UCLA/IMED c/o Cyndi Haddad, USA
Cross-Talk between the PI3K and MAPK Pathways Determines Prostate Cancer Metastasis

Wednesday, February 27 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 5 of 6
Kira Gritsman, Albert Einstein College of Medicine, USA
Short Talk: RAS-Mutated Myeloid Leukemias Are Dependent on the PI3 Kinase Isoform p110alpha

Wednesday, February 27 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 6 of 6
Maurizio Scaltriti, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: p90RSK Mediates Resistance to PI3K-Pathway Inhibitors in Breast Cancer

Wednesday, February 27 | 8:00AM - 11:00AM
Influence of the Microenvironment on Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 1 of 6
* Sally A. Kornbluth, Duke University Medical Center, USA


Wednesday, February 27 | 8:00AM - 11:00AM
Influence of the Microenvironment on Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 2 of 6
Jacques Pouysségur, University of Nice, France
Hypoxia Signaling, pHi Regulation and Tumor Metabolism: Novel Therapeutic Approaches


Wednesday, February 27 | 8:00AM - 11:00AM
Influence of the Microenvironment on Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 3 of 6
M. Celeste Simon, University of Pennsylvania, USA
Tumor Cell Adaptation to the Microenvironment


Wednesday, February 27 | 8:00AM - 11:00AM
Influence of the Microenvironment on Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 4 of 6
Amato J. Giaccia, Stanford University, USA
Oxygen Sensing and Metabolic Control


Wednesday, February 27 | 8:00AM - 11:00AM
Influence of the Microenvironment on Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 5 of 6
Brendan D. Manning, Harvard School of Public Health, USA
Tumor Cell Intrinsic Biosynthesis Driven by mTOR Signaling


Wednesday, February 27 | 8:00AM - 11:00AM
Influence of the Microenvironment on Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 6 of 6
Russell G. Jones, Van Andel Research Institute, USA
Short Talk: AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth in vivo


Wednesday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 27 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, February 27 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Wednesday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Wednesday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 27 | 5:00PM - 7:00PM
PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical)
Room: Grays Peak

Speaker 1 of 5
* Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland

Wednesday, February 27 | 5:00PM - 7:00PM
PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical)
Room: Grays Peak

Speaker 2 of 5
Julian H. Downward, Cancer Research UK, UK
Links between RAS Family GTPases and PI3K Signaling

Wednesday, February 27 | 5:00PM - 7:00PM
PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical)
Room: Grays Peak

Speaker 3 of 5
Peter K. Vogt, The Scripps Research Institute, USA
The PI3K Pathway in Cancer

Wednesday, February 27 | 5:00PM - 7:00PM
PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical)
Room: Grays Peak

Speaker 4 of 5
Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Role of Mutant PTEN in Tumorigenesis

Wednesday, February 27 | 5:00PM - 7:00PM
PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical)
Room: Grays Peak

Speaker 5 of 5
John P. O'Bryan, Medical University of South Carolina, USA
Short Talk: PI3KC2beta: Role in Tumorigenesis and Regulation by Nucleotide-Ras (nf-Ras)

Wednesday, February 27 | 5:00PM - 7:15PM
Insights from in vivo Experiments
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 1 of 5
* M. Celeste Simon, University of Pennsylvania, USA


Wednesday, February 27 | 5:00PM - 7:15PM
Insights from in vivo Experiments
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 2 of 5
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Tumor Metabolism: Insight from Mouse Models


Wednesday, February 27 | 5:00PM - 7:15PM
Insights from in vivo Experiments
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 3 of 5
Yanping Zhang, University of North Carolina at Chapel Hill, USA
The RP-Mdm2-p53 Pathway Links Nutrient Restriction to Lipid Homeostasis


Wednesday, February 27 | 5:00PM - 7:15PM
Insights from in vivo Experiments
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 4 of 5
Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Measuring Metabolism and Metabolites in vivo


Wednesday, February 27 | 5:00PM - 7:15PM
Insights from in vivo Experiments
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 5 of 5
Norman Koglin, Piramal Imaging GmbH, Germany
PET Imaging of Glutamate/Cystine Transporter Activity in Cancer Patients


Wednesday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Wednesday, February 27 | 7:30PM - 10:00PM
Poster Session 3
Room: Quandary Peak


Thursday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Thursday, February 28 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 1 of 6
* Bart Vanhaesebroeck, University College London, Cancer Institute, UK
PI 3-Kinase Isoforms in Cancer and Metabolism

Thursday, February 28 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 2 of 6
Davide Ruggero, University of California, San Francisco, USA
Reprogramming Translational Control of mRNA Networks in Cancer and its Therapeutic Implications

Thursday, February 28 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 3 of 6
Jonathan R. Hart, The Scripps Research Institute, USA
Pulsed SILAC: Enabling the Direct Observation of Changes in Protein Synthesis Caused by mTOR Inhibition

Thursday, February 28 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 4 of 6
William A. Weiss, University of California, San Francisco, USA
Kinases in Autophagy as Therapeutic Targets in Brain Cancer

Thursday, February 28 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 5 of 6
Vikki Flemington, AstraZeneca, UK
Short Talk: Phosphatidylinositol-4-Kinase – Potent and Selective Inhibitors of Type III PI 4-Kinases

Thursday, February 28 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 6 of 6
Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy
Short Talk: PI3K Class II alpha Controls Primary Cilium Function and Cell Proliferation in Development and Cancer

Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 1 of 7
* Jacques Pouysségur, University of Nice, France


Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 2 of 7
Bing Lim, Genome Institute of Singapore, Singapore
Targeting Glycine Metabolism for Cancer Therapy


Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 3 of 7
Susan E. Critchlow, AstraZeneca, UK
Targeting Lactate Metabolism in Cancer


Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 4 of 7
Sally A. Kornbluth, Duke University Medical Center, USA
Metabolic Control of Caspase 2-Mediated Cell Death


Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 5 of 7
Joan S. Brugge, Harvard Medical School, USA
Use of 3D Culture Models to Understand the Impact of Targeted Therapy on Metabolism


Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 6 of 7
Georgia Hatzivassiliou, Genentech, Inc., USA
Short Talk: Dissecting the Role of Glutaminase in Cancer


Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 7 of 7
Genshi Zhao, Eli Lilly and Company, USA
Short Talk: Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, in Human Cancer Cells: Metabolic Basis and Potential Clinical Implications


Thursday, February 28 | 9:00AM - 9:20AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 28 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, February 28 | 3:00PM - 4:30PM
Workshop 2: Novel Therapeutic Approaches
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 1 of 6
* Kate Yen, Auron Therapeutics, USA


Thursday, February 28 | 3:00PM - 4:30PM
Workshop 2: Novel Therapeutic Approaches
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 2 of 6
Steve Colebrook, Cancer Research UK, UK
A First-in-Man Phase I Trial of AZD3965, a Monocarboxylate Transporter 1 Inhibitor (MCT1), in Patients with Advanced Cancer


Thursday, February 28 | 3:00PM - 4:30PM
Workshop 2: Novel Therapeutic Approaches
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 3 of 6
Krushna C. Patra, Massachusetts General Hospital, Harvard Medical School, USA
Hexokinase 2 Is Required for Oncogenesis and its Systemic Deletion Is Therapeutic in Mouse Models of Cancer


Thursday, February 28 | 3:00PM - 4:30PM
Workshop 2: Novel Therapeutic Approaches
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 4 of 6
Alexandra R. Grassian, Novartis Institutes for BioMedical Research, USA
Mutant Isocitrate Dehydrogenase Promotes a Reversible Epithelial-Mesenchymal Transition and Alters Metabolic Flux


Thursday, February 28 | 3:00PM - 4:30PM
Workshop 2: Novel Therapeutic Approaches
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 5 of 6
Kelly E. Sullivan, Cornell University, USA
Elucidating the Regulation of Mitochondrial Glutaminase in Cancer Progression


Thursday, February 28 | 3:00PM - 4:30PM
Workshop 2: Novel Therapeutic Approaches
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 6 of 6
David R. Plas, University of Cincinnati, USA
Transition to Fatty Acid Oxidation Mediates Survival of BCR-ABL-Transformed Cells after Inhibition of mTORC1-S6K1


Thursday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 28 | 5:00PM - 7:00PM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 1 of 4
* David A. Fruman, University of California, Irvine, USA
Immune Effects of Anti-Cancer Drugs Targeting PI3K/mTOR

Thursday, February 28 | 5:00PM - 7:00PM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 2 of 4
Brendan D. Manning, Harvard School of Public Health, USA
Linking Oncogenic Signaling to Anabolic Metabolism through mTOR

Thursday, February 28 | 5:00PM - 7:00PM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 3 of 4
Ramon Parsons, Icahn School of Medicine at Mount Sinai, USA
PTEN Signaling

Thursday, February 28 | 5:00PM - 7:00PM
PI3K-Related Pathways (Preclinical)
Room: Grays Peak

Speaker 4 of 4
Ralph M. Fritsch, Cancer Research UK London Research Institute, UK
Short Talk: RAS and RHO Family GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

Thursday, February 28 | 5:00PM - 7:00PM
Influence of Metabolism on Epigenetic Regulation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 1 of 5
* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA


Thursday, February 28 | 5:00PM - 7:00PM
Influence of Metabolism on Epigenetic Regulation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 2 of 5
Lewis C. Cantley, Weill Cornell Medicine, USA
Metabolic Control of Histone Methylation


Thursday, February 28 | 5:00PM - 7:00PM
Influence of Metabolism on Epigenetic Regulation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 3 of 5
Kathryn E. Wellen, University of Pennsylvania, USA
Use of Metabolic Pathways to Sense Cell State


Thursday, February 28 | 5:00PM - 7:00PM
Influence of Metabolism on Epigenetic Regulation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 4 of 5
Kate Yen, Auron Therapeutics, USA
Mutation Selective IDH Inhibitors Mediate Histone and DNA Methylation Changes


Thursday, February 28 | 5:00PM - 7:00PM
Influence of Metabolism on Epigenetic Regulation
This session is from Tumor Metabolism
Room: Longs Peak

Speaker 5 of 5
Raul Mostoslavsky, Harvard Medical School, USA
Short Talk: The Histone Deacetylase SIRT6 Suppresses Cancer Metabolism


Thursday, February 28 | 7:00PM - 7:30PM
Panel Discussion
This session is from Tumor Metabolism

Speaker 1 of 1
* Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland


Thursday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Thursday, February 28 | 8:00PM - 11:00PM
Entertainment
Room: Quandary Peak


Thursday, February 28 | 8:00PM - 11:00PM
Cash Bar
Room: Quandary Peak


Friday, March 01 | 10:25AM - 10:25AM
Departure


*Session Chair.