Web Desc
Tumor Metabolism
joint with PI 3-Kinase and Interplay with Other Signaling Pathways
Organizer(s): Matthew G. Vander Heiden and Karen H. Vousden
Date: February 24 - March 01, 2013
Location: Keystone Resort, Keystone, CO, USA
Sponsored by AVEO Oncology and Bayer USA Foundation
For important information on the coronavirus, please click here
Summary of Meeting:
Proliferating tumor cells have different metabolic requirements than most normal differentiated cells. All cells consume nutrients to generate ATP and maintain homeostasis, however cell proliferation requires additional nutrient uptake to support macromolecular synthesis needed for cell growth. How metabolic pathways are regulated to balance these needs is not well understood, but mounting evidence suggests that metabolism is actively regulated to support cell growth, and that this regulation is intimately linked with the signal transduction pathways that control cell growth and proliferation. Metabolic changes represent some of the first differences ever noted between tumors and normal tissues. Yet, only recently has it been appreciated that many genetic events associated with cancer result in signal transduction changes to promote metabolism that is conducive to growth. This has accelerated research to understand metabolism in tumors with an eye toward targeting these pathways for improved cancer therapy. Substantial progress in the field has come from laboratories with diverse expertise providing new insights about metabolism and its regulation. However, a deeper understanding of tumor metabolism requires methods to assess metabolite flux and pathway regulation that historically have not been used to study cancer biology. Recent years have seen a remarkable advance in techniques available to interrogate metabolic pathways in vitro and in vivo. This work has been augmented by progress in modeling metabolic networks that facilitate interpretation of complex metabolism data to define key points of regulation. A growing cross talk between these systems biology approaches and traditional cancer biology studies has enabled increasingly sophisticated studies that enhance our understanding of tumor metabolism. Bringing together scientists with expertise in signal transduction, nutrient and oxygen sensing, genetic events affecting metabolism, metabolic flux measurements and network modeling will provide an opportunity to discuss the latest data informing metabolic regulation in tumors. These discussions will impact studies of metabolism in other contexts. Similarly, emerging data related to metabolic regulation in the immune systems can inform studies of tumor metabolism. PI-3 kinase is a critical regulator of metabolism and there have been numerous advances in understanding this signaling pathway; a joint meeting addressing PI-3 Kinase will enrich the dialogue across disciplines to explore how metabolism influences multiple aspects of biology.
Scholarship Deadline: October 25 2012
Discounted Abstract Deadline: October 25 2012
Abstract Deadline: November 28 2012
Discounted Registration Deadline: December 19 2012
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AVEO OncologyBayer USA Foundation
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Piramal Imaging GmbH
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA174034-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 24 | 3:00PM - 7:30PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, February 24 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Monday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Monday, February 25 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Longs Peak

Speaker 1 of 2
* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA

Monday, February 25 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Longs Peak

Speaker 2 of 2
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Metabolic Control of Tumor Cell Growth and Survival

Monday, February 25 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical - Part 1)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 1 of 5
* José Baselga, Memorial Sloan-Kettering Cancer Center, USA
Breast Cancer


Monday, February 25 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical - Part 1)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 2 of 5
Brett S. Carver, USA
Targeting the PI3K and AR Pathways in Prostate Cancer: Defining Mechanisms of Response and Resistance


Monday, February 25 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical - Part 1)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 3 of 5
Vito J. Palombella, USA
Development of the Potent PI3K-delta,gamma Inhibitor IPI-145


Monday, February 25 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical - Part 1)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 4 of 5
Khaled Ali, Barts Cancer Institute, UK
Short Talk: Inactivation of p110delta PI 3-Kinase Releases Anti-Tumor Immune Responses


Monday, February 25 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical - Part 1)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 5 of 5
Kyle A. Edgar, Genentech, Inc., USA
Short Talk: Mechanisms of Acquired Resistance to the PI3K Inhibitor, GDC-0941 in Colorectal Cancer Cell Lines


Monday, February 25 | 9:00AM - 11:00AM
Metabolic Regulation
Room: Longs Peak

Speaker 1 of 5
* Karen H. Vousden, Francis Crick Institute, UK

Monday, February 25 | 9:00AM - 11:00AM
Metabolic Regulation
Room: Longs Peak

Speaker 2 of 5
Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany
The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells

Monday, February 25 | 9:00AM - 11:00AM
Metabolic Regulation
Room: Longs Peak

Speaker 3 of 5
Linda Z. Penn, Princess Margaret Cancer Centre, Canada
The Mevalonate Pathway, Signaling and Tumor Vulnerability

Monday, February 25 | 9:00AM - 11:00AM
Metabolic Regulation
Room: Longs Peak

Speaker 4 of 5
Daniel S. Peeper, Netherlands Cancer Institute, Netherlands
Short Talk: A Critical Role for the Mitochondrial Gatekeeper Pyruvate Dehydrogenase in Oncogene-Induced Senescence

Monday, February 25 | 9:00AM - 11:00AM
Metabolic Regulation
Room: Longs Peak

Speaker 5 of 5
Jing Chen, Winship Cancer Institute, Emory University, USA
Short Talk: Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

Monday, February 25 | 9:40AM - 10:00AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 25 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Monday, February 25 | 11:00AM - 1:00PM
Poster Setup
Room: Quandary Peak


Monday, February 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
Room: Longs Peak

Speaker 1 of 7
* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA

Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
Room: Longs Peak

Speaker 2 of 7
Ji Zhang, Indiana University, USA
Why Cancer Cells Die without Glutamine?

Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
Room: Longs Peak

Speaker 3 of 7
Brandon N. Nicolay, Agios Pharmaceuticals, USA
Loss of RBF1 Changes Glutamine Catabolism

Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
Room: Longs Peak

Speaker 4 of 7
Ming Yang, Beatson Institute for Cancer Research, UK
Candidate Roles for Protein Succination in Altered Metabolism and Oncogenesis

Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
Room: Longs Peak

Speaker 5 of 7
Talya L. Dayton, Massachusetts Institute of Technology, USA
Elucidating a Role for Pkm Isoform Expression Specificity in vivo

Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
Room: Longs Peak

Speaker 6 of 7
Darin Salloum, Memorial Sloan Kettering Cancer Center, USA
Human Cancer Cells Harboring Ras Mutations Display Elevated Requirement for Serum Lipids

Monday, February 25 | 2:30PM - 4:30PM
Workshop 1: Metabolic Regulation and Adaptation
Room: Longs Peak

Speaker 7 of 7
Wei Liu, Frederick National Laboratory for Cancer Research, National Institutes of Health, USA
Proline Biosynthesis Augments MYC-Induced Aerobic Glycolysis and Cell Growth

Monday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 25 | 5:00PM - 7:00PM
Nutrient Sensing
Room: Longs Peak

Speaker 1 of 5
* Joan S. Brugge, Harvard Medical School, USA

Monday, February 25 | 5:00PM - 7:00PM
Nutrient Sensing
Room: Longs Peak

Speaker 2 of 5
Eileen P. White, Rutgers University, USA
Autophagy Maintains Mitochondrial Function and Tumorigenesis

Monday, February 25 | 5:00PM - 7:00PM
Nutrient Sensing
Room: Longs Peak

Speaker 3 of 5
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Metabolic Pathways Important for Cell Growth

Monday, February 25 | 5:00PM - 7:00PM
Nutrient Sensing
Room: Longs Peak

Speaker 4 of 5
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Large-Scale Approaches to Study Cancer Metabolism

Monday, February 25 | 5:00PM - 7:00PM
Nutrient Sensing
Room: Longs Peak

Speaker 5 of 5
Issam Ben-Sahra, Northwestern University, USA
Short Talk: Growth Signaling Stimulates Nucleotide Synthesis through mTOR

Monday, February 25 | 5:00PM - 7:00PM
PI3K/Akt/mTOR Pathway (Clinical - Part 2)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 1 of 4
Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA
Interplay Signaling


Monday, February 25 | 5:00PM - 7:00PM
PI3K/Akt/mTOR Pathway (Clinical - Part 2)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 2 of 4
Kui Lin, Genentech, Inc., USA
Akt


Monday, February 25 | 5:00PM - 7:00PM
PI3K/Akt/mTOR Pathway (Clinical - Part 2)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 3 of 4
Mark G. Manfredi, Raze Therapeutics, USA
The Development of MLN0128, an Investigational mTOR Active Site Inhibitor


Monday, February 25 | 5:00PM - 7:00PM
PI3K/Akt/mTOR Pathway (Clinical - Part 2)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 4 of 4
Kathryn Balmanno, Babraham Institute, UK
Short Talk: Modelling Acquired Resistance to mTOR Kinase Inhibitors


Monday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Monday, February 25 | 7:30PM - 10:00PM
Poster Session 1
Room: Quandary Peak


Tuesday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
Room: Longs Peak

Speaker 1 of 7
* David M. Sabatini, Whitehead Institute for Biomedical Research, USA

Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
Room: Longs Peak

Speaker 2 of 7
Brian J. Altman, University of Rochester, USA
Regulation of Cell Growth and Metabolism by Myc

Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
Room: Longs Peak

Speaker 3 of 7
Karen H. Vousden, Francis Crick Institute, UK
The Role of p53 in Metabolic Adaptation and Survival

Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
Room: Longs Peak

Speaker 4 of 7
Zachary Schug, Wistar Institute, USA
Targeting Lipid Metabolism in Breast Cancer

Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
Room: Longs Peak

Speaker 5 of 7
Reuben J. Shaw, The Salk Institute for Biological Studies, USA
The LKB1 Tumor Suppressor Pathway: Decoding Metabolic Links and Therapeutic Targeting

Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
Room: Longs Peak

Speaker 6 of 7
Costas A. Lyssiotis, University of Michigan, USA
Short Talk: Glutamine Metabolism Supports Pancreatic Tumor Growth and Redox Homeostasis

Tuesday, February 26 | 8:00AM - 11:15AM
Metabolic Adaptation
Room: Longs Peak

Speaker 7 of 7
Zhimin Lu, University of Texas MD Anderson Cancer Center, USA
Short Talk: The Warburg Effect and Beyond

Tuesday, February 26 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 1 of 6
* Jeffrey A. Engelman, Novartis Institutes for BioMedical Research, USA
Resistance Mechanisms


Tuesday, February 26 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 2 of 6
Sebastian M. B. Nijman, CeMM, Austrian Academy of Sciences, Austria
Gene-Drug Interaction Screens in Cancer


Tuesday, February 26 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 3 of 6
* Lori Friedman, ORIC Pharmaceuticals, USA
PI3K Inhibitor Combination Therapies


Tuesday, February 26 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 4 of 6
Jonathan M. Backer, Albert Einstein College of Medicine, USA
GPCR–Mediated Activation of p110beta by Gbetagamma Is Required for Cellular Transformation and Invasiveness


Tuesday, February 26 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 5 of 6
Wayne A. Phillips, Peter MacCallum Cancer Centre, Australia
Short Talk: Ubiquitous Expression of a Heterozygous Pik3ca Mutation Results in Increased Body Size, Hypoglycemia and Sudden Death


Tuesday, February 26 | 8:00AM - 11:15AM
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 6 of 6
Mamatha Bhat, University Health Network, Canada
Short Talk: Metformin Induces Apoptosis of Hepatocellular Carcinoma Downstream of mTORC1 through eIF4E


Tuesday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 26 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Tuesday, February 26 | 11:00AM - 1:00PM
Poster Setup
Room: Quandary Peak


Tuesday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Tuesday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 26 | 5:00PM - 7:00PM
Understanding the Metabolic Network
Room: Longs Peak

Speaker 1 of 5
* Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA

Tuesday, February 26 | 5:00PM - 7:00PM
Understanding the Metabolic Network
Room: Longs Peak

Speaker 2 of 5
Tomer Shlomi, Technion, Israel
An Integrated Computational-Experimental Approach for Finding Metabolic Synthetic Lethality in Cancer

Tuesday, February 26 | 5:00PM - 7:00PM
Understanding the Metabolic Network
Room: Longs Peak

Speaker 3 of 5
Joshua D. Rabinowitz, Princeton University, USA
Revealing Cancer Metabolism with Isotope Tracers

Tuesday, February 26 | 5:00PM - 7:00PM
Understanding the Metabolic Network
Room: Longs Peak

Speaker 4 of 5
Linda C. Hsieh-Wilson, California Institute of Technology, USA
Linking O-GlcNAc Signaling to Cancer Metabolism and Tumor Growth

Tuesday, February 26 | 5:00PM - 7:00PM
Understanding the Metabolic Network
Room: Longs Peak

Speaker 5 of 5
Stefan Kempa, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Quantifying Metabolic Routes in Cancer Cells Using Pulsed Stable Isotope Resolved Metabolomics (pSIRM)

Tuesday, February 26 | 5:00PM - 7:00PM
PI3K/mTOR Pathway - Signaling Networks (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 1 of 4
* Kevan M. Shokat, University of California, San Francisco, USA
Chemical Genetic Investigations of Protein and Lipid Kinase Signaling


Tuesday, February 26 | 5:00PM - 7:00PM
PI3K/mTOR Pathway - Signaling Networks (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 2 of 4
John Blenis, Weill Cornell Medical College, USA
Convergence and Integration of mTOR and Ras-ERK Signaling in Cancer


Tuesday, February 26 | 5:00PM - 7:00PM
PI3K/mTOR Pathway - Signaling Networks (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 3 of 4
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Regulation of Growth by the mTOR Pathway


Tuesday, February 26 | 5:00PM - 7:00PM
PI3K/mTOR Pathway - Signaling Networks (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 4 of 4
Tamara Chessa, Babraham Institute, UK
Short Talk: Dissecting the ClassIA PI3K Signalosome


Tuesday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Tuesday, February 26 | 7:30PM - 10:00PM
Poster Session 2
Room: Quandary Peak


Wednesday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Wednesday, February 27 | 8:00AM - 11:00AM
Influence of the Microenvironment on Metabolism
Room: Longs Peak

Speaker 1 of 6
* Sally A. Kornbluth, Duke University Medical Center, USA

Wednesday, February 27 | 8:00AM - 11:00AM
Influence of the Microenvironment on Metabolism
Room: Longs Peak

Speaker 2 of 6
Jacques Pouysségur, University of Nice, France
Hypoxia Signaling, pHi Regulation and Tumor Metabolism: Novel Therapeutic Approaches


Wednesday, February 27 | 8:00AM - 11:00AM
Influence of the Microenvironment on Metabolism
Room: Longs Peak

Speaker 3 of 6
M. Celeste Simon, University of Pennsylvania, USA
Tumor Cell Adaptation to the Microenvironment

Wednesday, February 27 | 8:00AM - 11:00AM
Influence of the Microenvironment on Metabolism
Room: Longs Peak

Speaker 4 of 6
Amato J. Giaccia, Stanford University, USA
Oxygen Sensing and Metabolic Control

Wednesday, February 27 | 8:00AM - 11:00AM
Influence of the Microenvironment on Metabolism
Room: Longs Peak

Speaker 5 of 6
Brendan D. Manning, Harvard School of Public Health, USA
Tumor Cell Intrinsic Biosynthesis Driven by mTOR Signaling

Wednesday, February 27 | 8:00AM - 11:00AM
Influence of the Microenvironment on Metabolism
Room: Longs Peak

Speaker 6 of 6
Russell G. Jones, Van Andel Research Institute, USA
Short Talk: AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth in vivo

Wednesday, February 27 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 1 of 6
* Lewis C. Cantley, Weill Cornell Medicine, USA
PI 3-Kinase, AMPK and Disease


Wednesday, February 27 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 2 of 6
Judith A. Varner, University of California, San Diego, USA
PI3K gamma Control of Innate Immunity in Cancer


Wednesday, February 27 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 3 of 6
Karen M. Cichowski, Brigham and Women's Hospital, Harvard Medical School, USA
Developing Combination Therapies with PI3K/mTOR Pathway Inhibitors


Wednesday, February 27 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 4 of 6
Hong Wu, UCLA/IMED c/o Cyndi Haddad, USA
Cross-Talk between the PI3K and MAPK Pathways Determines Prostate Cancer Metastasis


Wednesday, February 27 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 5 of 6
Kira Gritsman, Albert Einstein College of Medicine, USA
Short Talk: RAS-Mutated Myeloid Leukemias Are Dependent on the PI3 Kinase Isoform p110alpha


Wednesday, February 27 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 6 of 6
Maurizio Scaltriti, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: p90RSK Mediates Resistance to PI3K-Pathway Inhibitors in Breast Cancer


Wednesday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 27 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, February 27 | 11:00AM - 1:00PM
Poster Setup
Room: Quandary Peak


Wednesday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Wednesday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 27 | 5:00PM - 7:15PM
Insights from in vivo Experiments
Room: Longs Peak

Speaker 1 of 5
* M. Celeste Simon, University of Pennsylvania, USA

Wednesday, February 27 | 5:00PM - 7:15PM
Insights from in vivo Experiments
Room: Longs Peak

Speaker 2 of 5
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Tumor Metabolism: Insight from Mouse Models

Wednesday, February 27 | 5:00PM - 7:15PM
Insights from in vivo Experiments
Room: Longs Peak

Speaker 3 of 5
Yanping Zhang, University of North Carolina at Chapel Hill, USA
The RP-Mdm2-p53 Pathway Links Nutrient Restriction to Lipid Homeostasis

Wednesday, February 27 | 5:00PM - 7:15PM
Insights from in vivo Experiments
Room: Longs Peak

Speaker 4 of 5
Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Measuring Metabolism and Metabolites in vivo

Wednesday, February 27 | 5:00PM - 7:15PM
Insights from in vivo Experiments
Room: Longs Peak

Speaker 5 of 5
Norman Koglin, Piramal Imaging GmbH, Germany
PET Imaging of Glutamate/Cystine Transporter Activity in Cancer Patients

Wednesday, February 27 | 5:00PM - 7:00PM
PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 1 of 5
* Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland


Wednesday, February 27 | 5:00PM - 7:00PM
PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 2 of 5
Julian H. Downward, Cancer Research UK, UK
Links between RAS Family GTPases and PI3K Signaling


Wednesday, February 27 | 5:00PM - 7:00PM
PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 3 of 5
Peter K. Vogt, The Scripps Research Institute, USA
The PI3K Pathway in Cancer


Wednesday, February 27 | 5:00PM - 7:00PM
PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 4 of 5
Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Role of Mutant PTEN in Tumorigenesis


Wednesday, February 27 | 5:00PM - 7:00PM
PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 5 of 5
John P. O'Bryan, Medical University of South Carolina, USA
Short Talk: PI3KC2beta: Role in Tumorigenesis and Regulation by Nucleotide-Ras (nf-Ras)


Wednesday, February 27 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Quandary Peak


Wednesday, February 27 | 7:30PM - 10:00PM
Poster Session 3
Room: Quandary Peak


Thursday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
Room: Longs Peak

Speaker 1 of 7
* Jacques Pouysségur, University of Nice, France

Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
Room: Longs Peak

Speaker 2 of 7
Bing Lim, Genome Institute of Singapore, Singapore
Targeting Glycine Metabolism for Cancer Therapy

Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
Room: Longs Peak

Speaker 3 of 7
Susan E. Critchlow, AstraZeneca, UK
Targeting Lactate Metabolism in Cancer

Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
Room: Longs Peak

Speaker 4 of 7
Sally A. Kornbluth, Duke University Medical Center, USA
Metabolic Control of Caspase 2-Mediated Cell Death

Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
Room: Longs Peak

Speaker 5 of 7
Joan S. Brugge, Harvard Medical School, USA
Use of 3D Culture Models to Understand the Impact of Targeted Therapy on Metabolism

Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
Room: Longs Peak

Speaker 6 of 7
Georgia Hatzivassiliou, Genentech, Inc., USA
Short Talk: Dissecting the Role of Glutaminase in Cancer

Thursday, February 28 | 8:00AM - 11:00AM
Targeting Metabolism
Room: Longs Peak

Speaker 7 of 7
Genshi Zhao, Eli Lilly and Company, USA
Short Talk: Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, in Human Cancer Cells: Metabolic Basis and Potential Clinical Implications

Thursday, February 28 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 1 of 6
* Bart Vanhaesebroeck, University College London, Cancer Institute, UK
PI 3-Kinase Isoforms in Cancer and Metabolism


Thursday, February 28 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 2 of 6
Davide Ruggero, University of California, San Francisco, USA
Reprogramming Translational Control of mRNA Networks in Cancer and its Therapeutic Implications


Thursday, February 28 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 3 of 6
Jonathan R. Hart, The Scripps Research Institute, USA
Pulsed SILAC: Enabling the Direct Observation of Changes in Protein Synthesis Caused by mTOR Inhibition


Thursday, February 28 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 4 of 6
William A. Weiss, University of California, San Francisco, USA
Kinases in Autophagy as Therapeutic Targets in Brain Cancer


Thursday, February 28 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 5 of 6
Vikki Flemington, AstraZeneca, UK
Short Talk: Phosphatidylinositol-4-Kinase – Potent and Selective Inhibitors of Type III PI 4-Kinases


Thursday, February 28 | 8:00AM - 11:15AM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 6 of 6
Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy
Short Talk: PI3K Class II alpha Controls Primary Cilium Function and Cell Proliferation in Development and Cancer


Thursday, February 28 | 9:00AM - 9:20AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 28 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, February 28 | 3:00PM - 4:30PM
Workshop 2: Novel Therapeutic Approaches
Room: Longs Peak

Speaker 1 of 6
* Kate Yen, Auron Therapeutics, USA

Thursday, February 28 | 3:00PM - 4:30PM
Workshop 2: Novel Therapeutic Approaches
Room: Longs Peak

Speaker 2 of 6
Steve Colebrook, Cancer Research UK, UK
A First-in-Man Phase I Trial of AZD3965, a Monocarboxylate Transporter 1 Inhibitor (MCT1), in Patients with Advanced Cancer

Thursday, February 28 | 3:00PM - 4:30PM
Workshop 2: Novel Therapeutic Approaches
Room: Longs Peak

Speaker 3 of 6
Krushna C. Patra, Massachusetts General Hospital, Harvard Medical School, USA
Hexokinase 2 Is Required for Oncogenesis and its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

Thursday, February 28 | 3:00PM - 4:30PM
Workshop 2: Novel Therapeutic Approaches
Room: Longs Peak

Speaker 4 of 6
Alexandra R. Grassian, Novartis Institutes for BioMedical Research, USA
Mutant Isocitrate Dehydrogenase Promotes a Reversible Epithelial-Mesenchymal Transition and Alters Metabolic Flux

Thursday, February 28 | 3:00PM - 4:30PM
Workshop 2: Novel Therapeutic Approaches
Room: Longs Peak

Speaker 5 of 6
Kelly E. Sullivan, Cornell University, USA
Elucidating the Regulation of Mitochondrial Glutaminase in Cancer Progression

Thursday, February 28 | 3:00PM - 4:30PM
Workshop 2: Novel Therapeutic Approaches
Room: Longs Peak

Speaker 6 of 6
David R. Plas, University of Cincinnati, USA
Transition to Fatty Acid Oxidation Mediates Survival of BCR-ABL-Transformed Cells after Inhibition of mTORC1-S6K1

Thursday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 28 | 5:00PM - 7:00PM
Influence of Metabolism on Epigenetic Regulation
Room: Longs Peak

Speaker 1 of 5
* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA

Thursday, February 28 | 5:00PM - 7:00PM
Influence of Metabolism on Epigenetic Regulation
Room: Longs Peak

Speaker 2 of 5
Lewis C. Cantley, Weill Cornell Medicine, USA
Metabolic Control of Histone Methylation

Thursday, February 28 | 5:00PM - 7:00PM
Influence of Metabolism on Epigenetic Regulation
Room: Longs Peak

Speaker 3 of 5
Kathryn E. Wellen, University of Pennsylvania, USA
Use of Metabolic Pathways to Sense Cell State

Thursday, February 28 | 5:00PM - 7:00PM
Influence of Metabolism on Epigenetic Regulation
Room: Longs Peak

Speaker 4 of 5
Kate Yen, Auron Therapeutics, USA
Mutation Selective IDH Inhibitors Mediate Histone and DNA Methylation Changes

Thursday, February 28 | 5:00PM - 7:00PM
Influence of Metabolism on Epigenetic Regulation
Room: Longs Peak

Speaker 5 of 5
Raul Mostoslavsky, Harvard Medical School, USA
Short Talk: The Histone Deacetylase SIRT6 Suppresses Cancer Metabolism

Thursday, February 28 | 5:00PM - 7:00PM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 1 of 4
* David A. Fruman, University of California, Irvine, USA
Immune Effects of Anti-Cancer Drugs Targeting PI3K/mTOR


Thursday, February 28 | 5:00PM - 7:00PM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 2 of 4
Brendan D. Manning, Harvard School of Public Health, USA
Linking Oncogenic Signaling to Anabolic Metabolism through mTOR


Thursday, February 28 | 5:00PM - 7:00PM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 3 of 4
Ramon Parsons, Icahn School of Medicine at Mount Sinai, USA
PTEN Signaling


Thursday, February 28 | 5:00PM - 7:00PM
PI3K-Related Pathways (Preclinical)
This session is from PI 3-Kinase
Room: Grays Peak

Speaker 4 of 4
Ralph M. Fritsch, Cancer Research UK London Research Institute, UK
Short Talk: RAS and RHO Family GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms


Thursday, February 28 | 7:00PM - 7:30PM
Panel Discussion

Speaker 1 of 1
* Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland

Thursday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Thursday, February 28 | 8:00PM - 11:00PM
Entertainment
Room: Quandary Peak


Thursday, February 28 | 8:00PM - 11:00PM
Cash Bar
Room: Quandary Peak


Friday, March 01 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.