Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
DNA Replication and Genome Instability: From Mechanism to Disease (2019A1)
DNA Replication and Recombination (2017Z2)
DNA Replication and Recombination (2015X3)
Mobile Genetic Elements and Genome Evolution (2014C2)

Web Desc
DNA Replication and Recombination joint with Genomic Instability and DNA Repair Organizer(s): James M. Berger, Wolf-Dietrich Heyer and Julia Promisel Cooper Date: March 03 - 08, 2013 Location: Fairmont Banff Springs, Banff, AB, Canada Supported by the Directors' Fund Summary of Meeting: Cells universally rely on faithful genome duplication and maintenance for propagation and survival. Although frequently considered as independent systems or events, in recent years it has become clear that three of the most fundamental processes that support chromosome integrity and cell proliferation – DNA replication, repair, and recombination – are highly interconnected. At present, how these connections are manifest and controlled at a molecular level is not understood. Although significant advances have been made in identifying and understanding many of the machineries that govern these transactions, our knowledge of their fundamental molecular mechanisms is likewise incomplete. Aberrant replicative and repair-based processes have been firmly linked to biomedical problems such as mutation, tumorigenesis and numerous inherited diseases. Nonetheless, our understanding of how such detrimental phenotypes arise is still quite limited. This meeting aims to bring together scientists working at the forefront of DNA replication, recombination and repair under one umbrella. Topic sessions have been selected to delve into the interconnections between these fields in great detail, while at the same time highlighting the basic operating principles that link together the structure, function, and regulation of multiple systems that support chromosome viability and transmission. Talks at this meeting will describe the field’s most recent efforts to uncover new concepts in molecular function and cellular control, and to discover new proteins, interactions, and processes that can serve as targets both for understanding the genetic basis for disease (notably cancer) and for therapeutic intervention. Example topics include probing how replication forks respond to different types of DNA damage events, how DNA repair enzymes interface with the replisome and decide how best to mend a particular lesion, how recombination and other repair systems are used to heal and restart stalled forks, and how the telomeric ends of chromosomes are both replicated and play key roles in managing chromosome stability. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Genomic Instability and DNA Repair, which will share a keynote address and two plenary sessions with this meeting. Scholarship Deadline: November 7 2012 Discounted Abstract Deadline: November 7 2012 Abstract Deadline: December 4 2012 Discounted Registration Deadline: January 7 2013 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: University of Florida We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

DNA Replication and Recombination

joint with Genomic Instability and DNA Repair

Organizer(s): James M. Berger, Wolf-Dietrich Heyer and Julia Promisel Cooper

Date: March 03 - 08, 2013
Location: Fairmont Banff Springs, Banff, AB, Canada

Supported by the Directors' Fund

Summary of Meeting:

Cells universally rely on faithful genome duplication and maintenance for propagation and survival. Although frequently considered as independent systems or events, in recent years it has become clear that three of the most fundamental processes that support chromosome integrity and cell proliferation – DNA replication, repair, and recombination – are highly interconnected. At present, how these connections are manifest and controlled at a molecular level is not understood. Although significant advances have been made in identifying and understanding many of the machineries that govern these transactions, our knowledge of their fundamental molecular mechanisms is likewise incomplete. Aberrant replicative and repair-based processes have been firmly linked to biomedical problems such as mutation, tumorigenesis and numerous inherited diseases. Nonetheless, our understanding of how such detrimental phenotypes arise is still quite limited. This meeting aims to bring together scientists working at the forefront of DNA replication, recombination and repair under one umbrella. Topic sessions have been selected to delve into the interconnections between these fields in great detail, while at the same time highlighting the basic operating principles that link together the structure, function, and regulation of multiple systems that support chromosome viability and transmission. Talks at this meeting will describe the field’s most recent efforts to uncover new concepts in molecular function and cellular control, and to discover new proteins, interactions, and processes that can serve as targets both for understanding the genetic basis for disease (notably cancer) and for therapeutic intervention. Example topics include probing how replication forks respond to different types of DNA damage events, how DNA repair enzymes interface with the replisome and decide how best to mend a particular lesion, how recombination and other repair systems are used to heal and restart stalled forks, and how the telomeric ends of chromosomes are both replicated and play key roles in managing chromosome stability. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Genomic Instability and DNA Repair, which will share a keynote address and two plenary sessions with this meeting.

Scholarship Deadline: November 7 2012

Discounted Abstract Deadline: November 7 2012

Abstract Deadline: December 4 2012

Discounted Registration Deadline: January 7 2013

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

University of Florida

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 03 \| 3:00PM - 7:30PM Arrival and Registration Room: Van Horne Foyer
Sunday, March 03 \| 6:15PM - 7:15PM Refreshments Room: Van Horne Foyer
Sunday, March 03 \| 7:15PM - 9:30PM Welcome and Keynote Session (Joint) Room: Van Horne Ballroom A/B Speaker 1 of 4 * James M. Berger, Johns Hopkins University School of Medicine, USA
Sunday, March 03 \| 7:15PM - 9:30PM Welcome and Keynote Session (Joint) Room: Van Horne Ballroom A/B Speaker 2 of 4 * Stephen P. Jackson, University of Cambridge, UK
Sunday, March 03 \| 7:15PM - 9:30PM Welcome and Keynote Session (Joint) Room: Van Horne Ballroom A/B Speaker 3 of 4 Frederick W. Alt, Boston Children's Hospital, USA Mechanisms of Programmed DNA Rearrangements and Chromosomal Translocations in the Immune System
Sunday, March 03 \| 7:15PM - 9:30PM Welcome and Keynote Session (Joint) Room: Van Horne Ballroom A/B Speaker 4 of 4 Kenneth J. Marians, Memorial Sloan Kettering Cancer Center, USA Multiple Pathways to Reactivate Replication Forks Stalled by Damage in the Leading-Strand Template
Monday, March 04 \| 6:45AM - 8:00AM Breakfast Room: Mezzanine 2
Monday, March 04 \| 8:00AM - 11:15AM Mechanisms and Control of DNA Repair/Mechanisms of Homologou s Recombination (Joint) Room: Van Horne Ballroom A/B Speaker 1 of 7 * Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
Monday, March 04 \| 8:00AM - 11:15AM Mechanisms and Control of DNA Repair/Mechanisms of Homologou s Recombination (Joint) Room: Van Horne Ballroom A/B Speaker 2 of 7 Stephen C. Kowalczykowski, University of California, Davis, USA Single-Molecule Analysis of DNA Recombination
Monday, March 04 \| 8:00AM - 11:15AM Mechanisms and Control of DNA Repair/Mechanisms of Homologou s Recombination (Joint) Room: Van Horne Ballroom A/B Speaker 3 of 7 Maria Jasin, Memorial Sloan Kettering Cancer Center, USA Re-Considering the Role of BRCA1
Monday, March 04 \| 8:00AM - 11:15AM Mechanisms and Control of DNA Repair/Mechanisms of Homologou s Recombination (Joint) Room: Van Horne Ballroom A/B Speaker 4 of 7 Samuel F. Bunting, Rutgers University, USA Short Talk: BRCA1 Functions Independently in Excision of DNA Interstrand Crosslinks and in Homologous Recombination
Monday, March 04 \| 8:00AM - 11:15AM Mechanisms and Control of DNA Repair/Mechanisms of Homologou s Recombination (Joint) Room: Van Horne Ballroom A/B Speaker 5 of 7 Wolf-Dietrich Heyer, University of California, Davis, USA Mechanisms of Regulating Recombination
Monday, March 04 \| 8:00AM - 11:15AM Mechanisms and Control of DNA Repair/Mechanisms of Homologou s Recombination (Joint) Room: Van Horne Ballroom A/B Speaker 6 of 7 Roland Kanaar, Erasmus MC, Netherlands Modulation of Homologous Recombination
Monday, March 04 \| 8:00AM - 11:15AM Mechanisms and Control of DNA Repair/Mechanisms of Homologou s Recombination (Joint) Room: Van Horne Ballroom A/B Speaker 7 of 7 Douglas K. Bishop, University of Chicago, USA Short Talk: Overlapping RAD51-DMC1 foci come in well Separated Pairs: Symmetric Model for Meiotic Recombination
Monday, March 04 \| 9:20AM - 9:40AM Coffee Break Room: Van Horne Foyer
Monday, March 04 \| 11:15AM - 1:00PM Poster Setup Room: Mezzanine 2
Monday, March 04 \| 11:15AM - 4:30PM On Own for Lunch and Recreation
Monday, March 04 \| 1:00PM - 10:00PM Poster Viewing Room: Mezzanine 2
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: Regulation of DNA Superstructure Room: Van Horne Ballroom C Speaker 1 of 8 * Michael M. Cox, University of Wisconsin-Madison, USA
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: Regulation of DNA Superstructure Room: Van Horne Ballroom C Speaker 2 of 8 Erin A. Ronayne, University of Wisconsin, Madison, USA Structure and Function of the E. coli MgsA Protein
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: Regulation of DNA Superstructure Room: Van Horne Ballroom C Speaker 3 of 8 Manolis Papamichos-Chronakis, Institut Curie, France Integration of the INO80 Chromatin Remodeling Complex in the Ubiquitin-Mediated Protein Degradation Pathway Is Essential for Genome Stability
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: Regulation of DNA Superstructure Room: Van Horne Ballroom C Speaker 4 of 8 Margaret M. F. Renaud-Young, University of Calgary, Canada The NuA4 Complex Is a Novel Participant in the Translesion Synthesis Pathway of DNA Post Replication Repair
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: Regulation of DNA Superstructure Room: Van Horne Ballroom C Speaker 5 of 8 Liz Colby, Cancer Research UK, London Research Institute, UK Creating Site-Specific DNA Damage in S. cerevisiae to Study Replication-Associated Lesion Bypass
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: Regulation of DNA Superstructure Room: Van Horne Ballroom C Speaker 6 of 8 Mariana C. Gadaleta, Drexel University College of Medicine, USA Swi1 Prevents DNA Damage during Replication of Difficult-to-Replicate Sites
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: Regulation of DNA Superstructure Room: Van Horne Ballroom C Speaker 7 of 8 Diana E. Libuda, University of Oregon, USA Meiotic Chromosome Structures Constrain and Respond to Designation of Crossover Recombination Sites
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: Regulation of DNA Superstructure Room: Van Horne Ballroom C Speaker 8 of 8 Rebecca C. Burgess, National Cancer Institute, USA Activation of DNA Damage Response Signaling by Condensed Chromatin
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: DNA-Damage Checkpoint Signaling This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 1 of 8 * Aaron A. Goodarzi, Southern Alberta Cancer Research Institute, Canada
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: DNA-Damage Checkpoint Signaling This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 2 of 8 Ralph Scully, Beth Israel Deaconess Medical Center, USA Dephosphorylation of 53BP1 Is Necessary for its Function in the DNA Damage Response
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: DNA-Damage Checkpoint Signaling This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 3 of 8 Madalena Tarsounas, University of Oxford, UK EMBO Young Investigator Presenter: ARF Induces Senescence in Response to DNA Damage by Altering Expression of p53 Targets
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: DNA-Damage Checkpoint Signaling This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 4 of 8 Michela Di Virgilio, Rockefeller University, USA Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: DNA-Damage Checkpoint Signaling This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 5 of 8 J. Ross Chapman, University of Oxford, UK Rif1: A Critical Regulator of DNA Double-Strand Break Repair Required for Genome Stability and Immune Responses in Mice
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: DNA-Damage Checkpoint Signaling This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 6 of 8 Kyle M. Miller, USA Systematic Identification of Functional Residues in Mammalian Histone H2AX
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: DNA-Damage Checkpoint Signaling This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 7 of 8 Jean-Yves Masson, Laval University Cancer Research Center, Canada Function of PALB2 in DNA Double-Strand Break Repair and Recombination-Associated DNA Synthesis
Monday, March 04 \| 2:30PM - 4:30PM Workshop 1: DNA-Damage Checkpoint Signaling This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 8 of 8 Simon Bekker-Jensen, University of Copenhagen, Denmark Human RNF111 Is a Novel SUMO-Targeted Ubiquitin Ligase Functioning in the DNA Damage Response
Monday, March 04 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Monday, March 04 \| 5:00PM - 7:00PM Postreplication Repair/Restart Room: Van Horne Ballroom C Speaker 1 of 4 Johannes C. Walter, Harvard Medical School, USA Mechanisms of Replication-Coupled Crosslink Repair
Monday, March 04 \| 5:00PM - 7:00PM Postreplication Repair/Restart Room: Van Horne Ballroom C Speaker 2 of 4 James E. Haber, Brandeis University, USA Genome Stability and Instability: Repair of a Broken Chromosome
Monday, March 04 \| 5:00PM - 7:00PM Postreplication Repair/Restart Room: Van Horne Ballroom C Speaker 3 of 4 * Wei Yang, NIDDK, National Institutes of Health, USA Translesion DNA Synthesis: Chemistry and Cancer Biology
Monday, March 04 \| 5:00PM - 7:00PM Postreplication Repair/Restart Room: Van Horne Ballroom C Speaker 4 of 4 Maria Spies, University of Iowa, USA Short Talk: Priming Heteroduplex Rejection: hMSH2-hMSH6 Recognizes Mismatches within Recombination Intermediates
Monday, March 04 \| 5:00PM - 7:00PM Chromosomal Stability, Instability and Nuclear Architecture This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 1 of 4 * Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
Monday, March 04 \| 5:00PM - 7:00PM Chromosomal Stability, Instability and Nuclear Architecture This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 2 of 4 Stephen P. Jackson, University of Cambridge, UK Post-Translational Modifications Controlling the Assembly and Functions of Protein Complexes at DNA Damage Sites
Monday, March 04 \| 5:00PM - 7:00PM Chromosomal Stability, Instability and Nuclear Architecture This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 3 of 4 Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology, France Nuclear Compartmentalization and DNA Repair: Evidence for Reduced DDR at the Nuclear Periphery
Monday, March 04 \| 5:00PM - 7:00PM Chromosomal Stability, Instability and Nuclear Architecture This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 4 of 4 Ciaran G. Morrison, National University of Ireland, Galway, Ireland Short Talk: The Pericentriolar Material as a Hub for DNA Damage Checkpoints: Pericentrin and Mcph1 Control Nuclear Chk1 Activation
Monday, March 04 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Mezzanine 2
Monday, March 04 \| 7:30PM - 10:00PM Poster Session 1 Room: Mezzanine 2
Tuesday, March 05 \| 6:45AM - 8:00AM Breakfast Room: Mezzanine 2
Tuesday, March 05 \| 8:00AM - 11:15AM Replication Initiation Strategies across Species Room: Van Horne Ballroom C Speaker 1 of 6 * Stephen P. Bell, Massachusetts Institute of Technology, USA Is Helicase Competence Required for Helicase Loading?
Tuesday, March 05 \| 8:00AM - 11:15AM Replication Initiation Strategies across Species Room: Van Horne Ballroom C Speaker 2 of 6 Terry L. Orr-Weaver, Massachusetts Institute of Technology, USA Changes in Gene Copy Number as a Developmental Strategy and DNA Replication Model
Tuesday, March 05 \| 8:00AM - 11:15AM Replication Initiation Strategies across Species Room: Van Horne Ballroom C Speaker 3 of 6 Daniel L. Kaplan, Florida State University College of Medicine, USA Short Talk: Cdc45-ssDNA Interaction Is Important for Stalling the Helicase during Replication Stress
Tuesday, March 05 \| 8:00AM - 11:15AM Replication Initiation Strategies across Species Room: Van Horne Ballroom C Speaker 4 of 6 James M. Berger, Johns Hopkins University School of Medicine, USA Loading and Activation of a Bacterial Hexameric Helicase
Tuesday, March 05 \| 8:00AM - 11:15AM Replication Initiation Strategies across Species Room: Van Horne Ballroom C Speaker 5 of 6 J. Julian Blow, University of Dundee, UK How the Distribution and Regulation of Replication Origins Ensures Precise Chromosome Duplication
Tuesday, March 05 \| 8:00AM - 11:15AM Replication Initiation Strategies across Species Room: Van Horne Ballroom C Speaker 6 of 6 Philip Zegerman, University of Cambridge, UK Short Talk: DNA Replication Initiation Rates Control Cell Cycle Events at the Mid-Blastula Transition of Xenopus laevis
Tuesday, March 05 \| 8:00AM - 11:15AM Controlling DNA Damage Responses by Ubiquitylation and Sumoy lation This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 1 of 7 * Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada The Mystery of 53BP1 Recruitment
Tuesday, March 05 \| 8:00AM - 11:15AM Controlling DNA Damage Responses by Ubiquitylation and Sumoy lation This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 2 of 7 Dana Branzei, FIRC Institute of Molecular Oncology, Italy A SUMO-Dependent Chromatin Architectural Pathway Facilitates Error-Free DNA Damage Tolerance via Sister Chromatid Recombination
Tuesday, March 05 \| 8:00AM - 11:15AM Controlling DNA Damage Responses by Ubiquitylation and Sumoy lation This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 3 of 7 Kristijan Ramadan, University of Oxford, UK Short Talk: Premature Aging Syndrome in Human Is Caused by Mutations in p97/VCP-Cofactor DVC1/Spartan
Tuesday, March 05 \| 8:00AM - 11:15AM Controlling DNA Damage Responses by Ubiquitylation and Sumoy lation This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 4 of 7 Alan D. D'Andrea, Dana-Farber Cancer Institute, USA The Importance of UBCZ Domains
Tuesday, March 05 \| 8:00AM - 11:15AM Controlling DNA Damage Responses by Ubiquitylation and Sumoy lation This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 5 of 7 Petra Beli, Novo Nordisk Foundation Center for Protein Research, Denmark Short Talk: Systems-Wide Analysis of Ubiquitylation in Response to UV
Tuesday, March 05 \| 8:00AM - 11:15AM Controlling DNA Damage Responses by Ubiquitylation and Sumoy lation This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 6 of 7 Titia K. Sixma, Netherlands Cancer Institute, Netherlands Short Talk: RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling
Tuesday, March 05 \| 8:00AM - 11:15AM Controlling DNA Damage Responses by Ubiquitylation and Sumoy lation This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 7 of 7 Jacqueline J. Jacobs, Netherlands Cancer Institute, Netherlands EMBO Young Investigator Short Talk: New Factors Controlling Telomere-Driven Genomic Instability
Tuesday, March 05 \| 9:20AM - 9:40AM Coffee Break Room: Van Horne Foyer
Tuesday, March 05 \| 11:15AM - 1:00PM Poster Setup Room: Mezzanine 2
Tuesday, March 05 \| 11:15AM - 4:30PM On Own for Lunch and Recreation
Tuesday, March 05 \| 1:00PM - 10:00PM Poster Viewing Room: Mezzanine 2
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 2: DNA Repair/Recombination Processes Room: Van Horne Ballroom A/B Speaker 1 of 7 * Marc S. Wold, University of Iowa, USA New Insights into Repair-Specific Roles of Replication Protein A
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 2: DNA Repair/Recombination Processes Room: Van Horne Ballroom A/B Speaker 2 of 7 Andrea Regier Voth, NIDDK, National Institutes of Health, USA Structural Characterization of the Molecular Mechanism of the DNA Transposase Hermes
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 2: DNA Repair/Recombination Processes Room: Van Horne Ballroom A/B Speaker 3 of 7 Kayleigh Wardell, University of Sussex, UK RcrA, a Novel Protein at the Crossroads of Replication and Recombination
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 2: DNA Repair/Recombination Processes Room: Van Horne Ballroom A/B Speaker 4 of 7 Jordan R. Becker, University of Minnesota, USA Ubiquitinated PCNA Monitors Okazaki Fragment Processing
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 2: DNA Repair/Recombination Processes Room: Van Horne Ballroom A/B Speaker 5 of 7 Sabine S. Lange, University of Texas MD Anderson Cancer Center, USA Dual Role for Mammalian DNA Polymerase Zeta in Supporting Proliferative Responses and Maintaining Genome Stability
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 2: DNA Repair/Recombination Processes Room: Van Horne Ballroom A/B Speaker 6 of 7 Robin N. Eichmiller, State University of New York, Buffalo, USA Mutations in RAD1 Reveal Altered Regulation of Rad1-Rad10 Activity
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 2: DNA Repair/Recombination Processes Room: Van Horne Ballroom A/B Speaker 7 of 7 Georgios I. Karras, Whitehead Institute for Biomedical Research, USA Non-Canonical Role of the 9-1-1 Clamp in the Error-Free DNA Damage Tolerance Pathway
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 3: DNA Replication Processes Room: Van Horne Ballroom C Speaker 1 of 7 * Michael A. Trakselis, Baylor University, USA Formation of an Archaeal Primosome Complex Controls DNA Priming and Unwinding
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 3: DNA Replication Processes Room: Van Horne Ballroom C Speaker 2 of 7 Arek Kulczyk, Harvard Medical School, USA Single-Molecule Studies of the Replisome Structure and Dynamics
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 3: DNA Replication Processes Room: Van Horne Ballroom C Speaker 3 of 7 Ian M. Slaymaker, University of Southern California, USA Mini-Chromosome Maintenance Complexes Form a Filament to Remodel DNA Structure and Topology
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 3: DNA Replication Processes Room: Van Horne Ballroom C Speaker 4 of 7 Juan Méndez, Spanish National Cancer Research Centre, Spain PrimPol, a New Human DNA Primase/Polymerase, Is Involved in Translesion Synthesis and Recovery of Stalled Forks during Nuclear DNA Replication
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 3: DNA Replication Processes Room: Van Horne Ballroom C Speaker 5 of 7 Lindsey N. Williams, University of Washington, USA Checkpoint-Dependent Mutagenesis by Error-Prone DNA Polymerase epsilon Variants
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 3: DNA Replication Processes Room: Van Horne Ballroom C Speaker 6 of 7 Kin Fan On, London Research Institute, Clare Hall Laboratories, UK A Cell-Free DNA Replication System Using Pre-RCs Reconstituted with Purified Proteins
Tuesday, March 05 \| 2:30PM - 4:30PM Workshop 3: DNA Replication Processes Room: Van Horne Ballroom C Speaker 7 of 7 Viola Nähse-Kumpf, Institute for Cancer Research, Norwegian Radium Hospital, Norway Checkpoint Kinase WEE1 Protects Against Replication-Associated DNA Damage
Tuesday, March 05 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Tuesday, March 05 \| 5:00PM - 7:15PM Replication, Chromatin and Genome Instability (Joint) Room: Van Horne Ballroom A/B Speaker 1 of 6 * Sophie E. Polo, Paris Diderot University, France
Tuesday, March 05 \| 5:00PM - 7:15PM Replication, Chromatin and Genome Instability (Joint) Room: Van Horne Ballroom A/B Speaker 2 of 6 Geneviève Almouzni, Centre National de la Recherche Scientifique, France Chromatin Assembly from Nucleosome to Heterochromatin: The Issue of DNA Damage and Genome Instability
Tuesday, March 05 \| 5:00PM - 7:15PM Replication, Chromatin and Genome Instability (Joint) Room: Van Horne Ballroom A/B Speaker 3 of 6 Ian D. Hickson, University of Copenhagen, Denmark Resolution of Stalled Replication Forks and Late Replication Intermediates
Tuesday, March 05 \| 5:00PM - 7:15PM Replication, Chromatin and Genome Instability (Joint) Room: Van Horne Ballroom A/B Speaker 4 of 6 Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland The Spatial Dynamics of Repair
Tuesday, March 05 \| 5:00PM - 7:15PM Replication, Chromatin and Genome Instability (Joint) Room: Van Horne Ballroom A/B Speaker 5 of 6 Jennifer A. Cobb, University of Calgary, Canada Short Talk: Nej1 C-Terminus Is Critical for Efficient Nonhomologous End-Joining in S. cerevisiae
Tuesday, March 05 \| 5:00PM - 7:15PM Replication, Chromatin and Genome Instability (Joint) Room: Van Horne Ballroom A/B Speaker 6 of 6 Brendan D. Price, Dana-Farber Cancer Institute, USA Short Talk: Histone H2A.Z Regulates Chromatin Structure and End-Resection by CtIP at DSBs
Tuesday, March 05 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Mezzanine 2
Tuesday, March 05 \| 7:30PM - 10:00PM Poster Session 2 Room: Mezzanine 2
Wednesday, March 06 \| 6:45AM - 8:00AM Breakfast Room: Mezzanine 2
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Structure and Maintenance Room: Van Horne Ballroom C Speaker 1 of 6 * Lorraine S. Symington, Columbia University, USA RPA Coordinates DNA End Resection and Prevents Formation of Hairpins
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Structure and Maintenance Room: Van Horne Ballroom C Speaker 2 of 6 * Simon J. Boulton, Francis Crick Institute, UK Replication Blocking Lesions. HelQ: Role in DNA Repair
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Structure and Maintenance Room: Van Horne Ballroom C Speaker 3 of 6 Massimo Lopes, University of Zürich, Switzerland EMBO Young Investigator Short Talk: Remodelling of Replication Intermediates upon DNA Replication Stress
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Structure and Maintenance Room: Van Horne Ballroom C Speaker 4 of 6 Stephen C. West, Francis Crick Institute, UK Alternative Pathways for Holliday Junction Resolution in Human Cells
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Structure and Maintenance Room: Van Horne Ballroom C Speaker 5 of 6 Akira Shinohara, Osaka University, Japan Control of Meiotic Recombination by Rad51 Mediators and DNA Helicases
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Structure and Maintenance Room: Van Horne Ballroom C Speaker 6 of 6 Gary Karpen, University of California, Berkeley, USA Short Talk: Heterochromatin and Nuclear Pore Proteins Regulate the Spatial and Temporal Dynamics of Recombination Repair among Repeated DNAs
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Instability, Telomeres, Disease and Aging. Session sp onsored by The Ellison Medical Foundation. This session is from Genomic Instability Room: Van Horne Ballroom A/B Support for these organizer-selected speakers generously provided by this foundation. Speaker 1 of 7 * Susan P. Lees-Miller, University of Calgary, Canada
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Instability, Telomeres, Disease and Aging. Session sp onsored by The Ellison Medical Foundation. This session is from Genomic Instability Room: Van Horne Ballroom A/B Support for these organizer-selected speakers generously provided by this foundation. Speaker 2 of 7 Titia de Lange, Rockefeller University, USA TRF2 Promotes T-Loop Formation to Block ATM Signaling and NHEJ at Chromosome Ends
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Instability, Telomeres, Disease and Aging. Session sp onsored by The Ellison Medical Foundation. This session is from Genomic Instability Room: Van Horne Ballroom A/B Support for these organizer-selected speakers generously provided by this foundation. Speaker 3 of 7 André Nussenzweig, NCI, National Institutes of Health, USA Identification of a Novel Class of Early Replicating Fragile Sites that Contribute to Genomic Instability in B Cell Lymphomas
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Instability, Telomeres, Disease and Aging. Session sp onsored by The Ellison Medical Foundation. This session is from Genomic Instability Room: Van Horne Ballroom A/B Support for these organizer-selected speakers generously provided by this foundation. Speaker 4 of 7 Catherine H. Freudenreich, Tufts University, USA Short Talk: Regulation of Acetylation on the Histone H4 Tail Maintains Fidelity of Homologous Recombination and Prevents CAG Expansions
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Instability, Telomeres, Disease and Aging. Session sp onsored by The Ellison Medical Foundation. This session is from Genomic Instability Room: Van Horne Ballroom A/B Support for these organizer-selected speakers generously provided by this foundation. Speaker 5 of 7 Laura J. Niedernhofer, The Scripps Research Institute, USA The Mechanism by which DNA Repair Protects Against Aging
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Instability, Telomeres, Disease and Aging. Session sp onsored by The Ellison Medical Foundation. This session is from Genomic Instability Room: Van Horne Ballroom A/B Support for these organizer-selected speakers generously provided by this foundation. Speaker 6 of 7 Keith W. Caldecott, University of Sussex, UK Topoisomerase-Induced DNA Double Strand Breakage and Repair in Human Disease
Wednesday, March 06 \| 8:00AM - 11:15AM Genome Instability, Telomeres, Disease and Aging. Session sp onsored by The Ellison Medical Foundation. This session is from Genomic Instability Room: Van Horne Ballroom A/B Support for these organizer-selected speakers generously provided by this foundation. Speaker 7 of 7 Carl L. Schildkraut, Albert Einstein College of Medicine, USA Short Talk: DNA Replication Fork Progression through the Fragile X and Telomere Repeats
Wednesday, March 06 \| 9:20AM - 9:40AM Coffee Break Room: Van Horne Foyer
Wednesday, March 06 \| 11:15AM - 1:00PM Poster Setup Room: Mezzanine 2
Wednesday, March 06 \| 11:15AM - 4:30PM On Own for Lunch and Recreation
Wednesday, March 06 \| 1:00PM - 10:00PM Poster Viewing Room: Mezzanine 2
Wednesday, March 06 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Wednesday, March 06 \| 5:00PM - 7:00PM Topological Transformations in DNA Room: Van Horne Ballroom C Speaker 1 of 4 * Phoebe A. Rice, University of Chicago, USA The How, When and Where of Site-Specific DNA Recombination
Wednesday, March 06 \| 5:00PM - 7:00PM Topological Transformations in DNA Room: Van Horne Ballroom C Speaker 2 of 4 Camilla Sjögren, Karolinska Institutet, Sweden Sister Chromatid Intertwinings and the SMC Complexes
Wednesday, March 06 \| 5:00PM - 7:00PM Topological Transformations in DNA Room: Van Horne Ballroom C Speaker 3 of 4 Claire Wyman, Erasmus Medical Center, Netherlands The 'See Me, Feel Me' Approach to Understand Key Steps in Homologous Recombination
Wednesday, March 06 \| 5:00PM - 7:00PM Topological Transformations in DNA Room: Van Horne Ballroom C Speaker 4 of 4 Jon Baxter, University of Sussex, UK Short Talk: The Yeast Pif1 Family Helicase RRM3 Promotes DNA Unwinding during Replication Fork Swiveling
Wednesday, March 06 \| 5:00PM - 7:00PM DNA Damage and Links to Transcription, RNA Metabolism and Ot her Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 1 of 6 * David Cortez, Vanderbilt University School of Medicine, USA
Wednesday, March 06 \| 5:00PM - 7:00PM DNA Damage and Links to Transcription, RNA Metabolism and Ot her Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 2 of 6 Andrés Aguilera, University of Seville, CABIMER, Spain Mechanisms of Transcription- and RNA-Induced DNA Damage and Genome Instability
Wednesday, March 06 \| 5:00PM - 7:00PM DNA Damage and Links to Transcription, RNA Metabolism and Ot her Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 3 of 6 Karlene A. Cimprich, Stanford University, USA Novel Mechanisms for Maintaining Genome Stability
Wednesday, March 06 \| 5:00PM - 7:00PM DNA Damage and Links to Transcription, RNA Metabolism and Ot her Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 4 of 6 Scott R. Floyd, Duke University, USA Short Talk: Linking Chromatin State to Signaling Networks in the DDR
Wednesday, March 06 \| 5:00PM - 7:00PM DNA Damage and Links to Transcription, RNA Metabolism and Ot her Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 5 of 6 Uttiya Basu, USA Short Talk: B Cell Genome Mutator AID Is Regulated in the RNA Polymerase II Associated Transcriptional Complex by E3-Ubiquitin Ligase NEDD4
Wednesday, March 06 \| 5:00PM - 7:00PM DNA Damage and Links to Transcription, RNA Metabolism and Ot her Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 6 of 6 Manuel Stucki, University of Zurich, Switzerland Short Talk: NBS1 and the Nucleolar Response to DNA Double-Strand Breaks
Wednesday, March 06 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Mezzanine 2
Wednesday, March 06 \| 7:30PM - 10:00PM Poster Session 3 Room: Mezzanine 2
Thursday, March 07 \| 6:45AM - 8:00AM Breakfast Room: Mezzanine 2
Thursday, March 07 \| 7:30AM - 8:00AM Poster Setup Room: Mezzanine 2
Thursday, March 07 \| 8:00AM - 5:00PM Poster Viewing Room: Mezzanine 2
Thursday, March 07 \| 8:00AM - 11:15AM Replication Elongation Machineries Room: Van Horne Ballroom C Speaker 1 of 6 David J. Sherratt, University of Oxford, UK High-Resolution in vivo Analysis of Bacterial Chromosome Replication and Recombination
Thursday, March 07 \| 8:00AM - 11:15AM Replication Elongation Machineries Room: Van Horne Ballroom C Speaker 2 of 6 * Peter M. Burgers, Washington University School of Medicine, USA Connecting DNA Damage to Checkpoint Initiation
Thursday, March 07 \| 8:00AM - 11:15AM Replication Elongation Machineries Room: Van Horne Ballroom C Speaker 3 of 6 John A. Tainer, The Scripps Research Institute, USA Short Talk: MRE11 Complex Regulates Repair Pathway Choice as Shown by Chemical Knockdown of Specific Activities
Thursday, March 07 \| 8:00AM - 11:15AM Replication Elongation Machineries Room: Van Horne Ballroom C Speaker 4 of 6 Stephen D. Bell, Indiana University, USA The Okazakisome
Thursday, March 07 \| 8:00AM - 11:15AM Replication Elongation Machineries Room: Van Horne Ballroom C Speaker 5 of 6 Linda B. Bloom, University of Florida, USA Clamp Loading Mechanisms
Thursday, March 07 \| 8:00AM - 11:15AM Replication Elongation Machineries Room: Van Horne Ballroom C Speaker 6 of 6 Nicholas E. Dixon, University of Wollongong, Australia Short Talk: An epsilon-beta Interaction in E. coli DNA Polymerase III Stabilizes the Replicase in the Polymerization Mode
Thursday, March 07 \| 8:00AM - 11:00AM Genomic and Genome-Wide Studies This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 1 of 7 * Karlene A. Cimprich, Stanford University, USA
Thursday, March 07 \| 8:00AM - 11:00AM Genomic and Genome-Wide Studies This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 2 of 7 Michael Stratton, Wellcome Trust Sanger Institute, UK Signatures of Mutational Processes Operative in Human Cancers
Thursday, March 07 \| 8:00AM - 11:00AM Genomic and Genome-Wide Studies This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 3 of 7 David Cortez, Vanderbilt University School of Medicine, USA Identification and Characterization of Mammalian Genome Maintenance Proteins
Thursday, March 07 \| 8:00AM - 11:00AM Genomic and Genome-Wide Studies This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 4 of 7 Ryan L. Ragland, Perelman School of Medicine, University of Pennsylvania, USA Short Talk: Genome-Wide Identification of Replication-Associated Breakpoints
Thursday, March 07 \| 8:00AM - 11:00AM Genomic and Genome-Wide Studies This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 5 of 7 Marcel Tijsterman, Leiden University Medical Center, Netherlands Pol theta Mediated end Joining of DNA Breaks Induced by Replication Fork Barriers
Thursday, March 07 \| 8:00AM - 11:00AM Genomic and Genome-Wide Studies This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 6 of 7 Peter C. Stirling, University of British Columbia, Canada Short Talk: Systematic Genetic and Cytological Analysis of Genome Integrity Pathways in Yeast
Thursday, March 07 \| 8:00AM - 11:00AM Genomic and Genome-Wide Studies This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 7 of 7 Gaëlle Legube, Center for Integrative Biology, France Short Talk: Transcription Channels DNA Double Strand Breaks to a RAD51-Dependent Repair Pathway
Thursday, March 07 \| 9:20AM - 9:40AM Coffee Break Room: Van Horne Foyer
Thursday, March 07 \| 11:15AM - 12:00PM Lunch Room: Mezzanine 2
Thursday, March 07 \| 12:00PM - 2:30PM Poster Session 4 Room: Mezzanine 2
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 4: Enzymes Acting on Nucleic Acids Room: Van Horne Ballroom C Speaker 1 of 7 * John L. Nitiss, University of Illinois, USA A Mutation in Eukaryotic Topoisomerase II that Mimics the Action of Topoisomerase Poisons: Role of the C-Terminal Dimerization Domain in Regulation of DNA Cleavage
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 4: Enzymes Acting on Nucleic Acids Room: Van Horne Ballroom C Speaker 2 of 7 Ilya J. Finkelstein, University of Texas at Austin, USA Single Molecule Imaging Reveals the Mechanisms of Roadblock Clearance by DNA-Binding Motor Enzymes
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 4: Enzymes Acting on Nucleic Acids Room: Van Horne Ballroom C Speaker 3 of 7 Aaron C. Mason, Vanderbilt University, USA Structural Insight into the Mechanism of the DNA Damage Response Protein Smarcal1
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 4: Enzymes Acting on Nucleic Acids Room: Van Horne Ballroom C Speaker 4 of 7 Hannah E. Mischo, Clare Hall Laboratories, London Research Institute, UK Connections between Transcription Termination and Genome Integrity: Dissecting the Function of the Superfamily I Helicase Sen1
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 4: Enzymes Acting on Nucleic Acids Room: Van Horne Ballroom C Speaker 5 of 7 Alessandro Vindigni, St. Louis University, USA Mechanistic Insight into Replication Fork Reversal and Restart Under Genotoxic Stress
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 4: Enzymes Acting on Nucleic Acids Room: Van Horne Ballroom C Speaker 6 of 7 Alessandro Costa, Francis Crick Institute, UK Structure of the Bloom's Complex: Insights into the Mechanism of Double Holliday Junction Dissolution
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 4: Enzymes Acting on Nucleic Acids Room: Van Horne Ballroom C Speaker 7 of 7 Sarah Wessel, University of Wisconsin, USA Molecular Interactions in PriC-Mediated DNA Replication Restart
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 2: DNA DSB Repair and Associated Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 1 of 9 * Ralph Scully, Beth Israel Deaconess Medical Center, USA
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 2: DNA DSB Repair and Associated Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 2 of 9 Katheryn D. Meek, Michigan State University, USA Unraveling the Complexities of DNA-PK Autophosphorylation
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 2: DNA DSB Repair and Associated Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 3 of 9 Alessandro A. Sartori, Institute of Molecular Cancer Research, Switzerland The Human PIN1 Isomerase Regulates DSB Repair
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 2: DNA DSB Repair and Associated Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 4 of 9 Jacques Côté, Laval University Cancer Research Center, Canada Phospho-Dependent Recruitment of NuA4 by MRX at DNA Breaks Regulates RPA Dynamics during Resection
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 2: DNA DSB Repair and Associated Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 5 of 9 Lei Li, University of Alberta, Canada DEAD Box 1 Interacts with Rif1 and Promotes Homologous DNA Repair
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 2: DNA DSB Repair and Associated Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 6 of 9 Martin A. M. Reijns, MRC Institute for Genetics and Molecular Medicine, UK Ribonuclease H2 Is Essential for the Removal of Misincorporated Ribonucleotides and for Mammalian Genome Integrity
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 2: DNA DSB Repair and Associated Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 7 of 9 David O. Ferguson, University of Michigan Medical School, USA Mre11 Interacts with Cyclin-Dependent Kinase 2 to Regulate Double Strand Break Repair
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 2: DNA DSB Repair and Associated Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 8 of 9 Nidhi Nair, University of Dundee, UK Slx1 and Mus81 Nucleases Cooperate in Holliday Junction Resolution
Thursday, March 07 \| 2:30PM - 4:30PM Workshop 2: DNA DSB Repair and Associated Processes This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 9 of 9 Priscilla K. Cooper, Environment Mutagen Society, USA XPG Partners with BRCA2 to Promote Homologous Recombination and Maintain Genome Stability
Thursday, March 07 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Thursday, March 07 \| 5:00PM - 7:00PM Replicating Challenging Regions Room: Van Horne Ballroom C Speaker 1 of 4 * Virginia A. Zakian, Princeton University, USA Conservation of Functions in Pif1 Family Helicases
Thursday, March 07 \| 5:00PM - 7:00PM Replicating Challenging Regions Room: Van Horne Ballroom C Speaker 2 of 4 Joachim Lingner, École Polytechnique Fédérale de Lausanne, Switzerland The THO Complex Counteracts Telomeric R-Loops and Telomere Instability
Thursday, March 07 \| 5:00PM - 7:00PM Replicating Challenging Regions Room: Van Horne Ballroom C Speaker 3 of 4 Maria Teresa Teixeira, CNRS – UMR 8226, France Short Talk: The DNA End Replication Problem and the Establishment of Replicative Senescence in Saccharomyces cerevisiae
Thursday, March 07 \| 5:00PM - 7:00PM Replicating Challenging Regions Room: Van Horne Ballroom C Speaker 4 of 4 Julia Promisel Cooper, NCI, National Institutes of Health, USA Solving the End Replication and Protection Problems without Telomerase or Telomere Repeats
Thursday, March 07 \| 5:00PM - 7:15PM Diagnostic and Therapeutic Applications This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 1 of 6 * Stephen P. Jackson, University of Cambridge, UK
Thursday, March 07 \| 5:00PM - 7:15PM Diagnostic and Therapeutic Applications This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 2 of 6 Thomas Helleday, Karolinska Institutet, Sweden Therapeutic Strategies for Cancer Based on DNA Repair Inhibition
Thursday, March 07 \| 5:00PM - 7:15PM Diagnostic and Therapeutic Applications This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 3 of 6 Jos Jonkers, Netherlands Cancer Institute, Netherlands DDR-Based Therapeutic Strategies and Resistance Mechanisms
Thursday, March 07 \| 5:00PM - 7:15PM Diagnostic and Therapeutic Applications This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 4 of 6 Óscar Fernández-Capetillo, Spanish National Cancer Research Centre, Spain Exploring the Role of Replicative Stress in Cancer and Aging
Thursday, March 07 \| 5:00PM - 7:15PM Diagnostic and Therapeutic Applications This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 5 of 6 Yves G. Pommier, NCI, National Institutes of Health, USA Short Talk: PARP1-TDP1 Partnership for DNA Repair and Processing of Top1-DNA Complexes
Thursday, March 07 \| 5:00PM - 7:15PM Diagnostic and Therapeutic Applications This session is from Genomic Instability Room: Van Horne Ballroom A/B Speaker 6 of 6 Michael Weinfeld, University of Alberta, Canada Short Talk: Synthetic Lethality through Targeted Disruption of Polynucleotide Kinase/Phosphatase
Thursday, March 07 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Mezzanine 2
Thursday, March 07 \| 8:00PM - 11:00PM Entertainment Room: Mezzanine 2
Thursday, March 07 \| 8:00PM - 11:00PM Cash Bar Room: Mezzanine 2
Friday, March 08 \| 10:25AM - 10:25AM Departure *Session Chair.