Web Desc
DNA Replication and Recombination
joint with Genomic Instability and DNA Repair
Organizer(s): James M. Berger, Wolf-Dietrich Heyer and Julia Promisel Cooper
Date: March 03 - 08, 2013
Location: Fairmont Banff Springs, Banff, AB, Canada
Supported by the Directors' Fund
Summary of Meeting:
Cells universally rely on faithful genome duplication and maintenance for propagation and survival. Although frequently considered as independent systems or events, in recent years it has become clear that three of the most fundamental processes that support chromosome integrity and cell proliferation – DNA replication, repair, and recombination – are highly interconnected. At present, how these connections are manifest and controlled at a molecular level is not understood. Although significant advances have been made in identifying and understanding many of the machineries that govern these transactions, our knowledge of their fundamental molecular mechanisms is likewise incomplete. Aberrant replicative and repair-based processes have been firmly linked to biomedical problems such as mutation, tumorigenesis and numerous inherited diseases. Nonetheless, our understanding of how such detrimental phenotypes arise is still quite limited. This meeting aims to bring together scientists working at the forefront of DNA replication, recombination and repair under one umbrella. Topic sessions have been selected to delve into the interconnections between these fields in great detail, while at the same time highlighting the basic operating principles that link together the structure, function, and regulation of multiple systems that support chromosome viability and transmission. Talks at this meeting will describe the field’s most recent efforts to uncover new concepts in molecular function and cellular control, and to discover new proteins, interactions, and processes that can serve as targets both for understanding the genetic basis for disease (notably cancer) and for therapeutic intervention. Example topics include probing how replication forks respond to different types of DNA damage events, how DNA repair enzymes interface with the replisome and decide how best to mend a particular lesion, how recombination and other repair systems are used to heal and restart stalled forks, and how the telomeric ends of chromosomes are both replicated and play key roles in managing chromosome stability. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Genomic Instability and DNA Repair, which will share a keynote address and two plenary sessions with this meeting.
Scholarship Deadline: November 7 2012
Discounted Abstract Deadline: November 7 2012
Abstract Deadline: December 4 2012
Discounted Registration Deadline: January 7 2013
We gratefully acknowledge additional support for this conference from:
BioVentures, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

University of Florida
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 03 | 3:00PM - 7:30PM
Arrival and Registration
Room: Van Horne Foyer


Sunday, March 03 | 6:15PM - 7:15PM
Refreshments
Room: Van Horne Foyer


Sunday, March 03 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 4
* James M. Berger, Johns Hopkins University School of Medicine, USA

Sunday, March 03 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne Ballroom A/B

Speaker 2 of 4
* Stephen P. Jackson, University of Cambridge, UK

Sunday, March 03 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne Ballroom A/B

Speaker 3 of 4
Frederick W. Alt, Boston Children's Hospital, USA
Mechanisms of Programmed DNA Rearrangements and Chromosomal Translocations in the Immune System

Sunday, March 03 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Van Horne Ballroom A/B

Speaker 4 of 4
Kenneth J. Marians, Memorial Sloan Kettering Cancer Center, USA
Multiple Pathways to Reactivate Replication Forks Stalled by Damage in the Leading-Strand Template

Monday, March 04 | 6:45AM - 8:00AM
Breakfast
Room: Mezzanine 2


Monday, March 04 | 8:00AM - 11:15AM
Mechanisms and Control of DNA Repair/Mechanisms of Homologou
s Recombination (Joint)

Room: Van Horne Ballroom A/B

Speaker 1 of 7
* Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland

Monday, March 04 | 8:00AM - 11:15AM
Mechanisms and Control of DNA Repair/Mechanisms of Homologou
s Recombination (Joint)

Room: Van Horne Ballroom A/B

Speaker 2 of 7
Stephen C. Kowalczykowski, University of California, Davis, USA
Single-Molecule Analysis of DNA Recombination

Monday, March 04 | 8:00AM - 11:15AM
Mechanisms and Control of DNA Repair/Mechanisms of Homologou
s Recombination (Joint)

Room: Van Horne Ballroom A/B

Speaker 3 of 7
Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Re-Considering the Role of BRCA1

Monday, March 04 | 8:00AM - 11:15AM
Mechanisms and Control of DNA Repair/Mechanisms of Homologou
s Recombination (Joint)

Room: Van Horne Ballroom A/B

Speaker 4 of 7
Samuel F. Bunting, Rutgers University, USA
Short Talk: BRCA1 Functions Independently in Excision of DNA Interstrand Crosslinks and in Homologous Recombination

Monday, March 04 | 8:00AM - 11:15AM
Mechanisms and Control of DNA Repair/Mechanisms of Homologou
s Recombination (Joint)

Room: Van Horne Ballroom A/B

Speaker 5 of 7
Wolf-Dietrich Heyer, University of California, Davis, USA
Mechanisms of Regulating Recombination

Monday, March 04 | 8:00AM - 11:15AM
Mechanisms and Control of DNA Repair/Mechanisms of Homologou
s Recombination (Joint)

Room: Van Horne Ballroom A/B

Speaker 6 of 7
Roland Kanaar, Erasmus MC, Netherlands
Modulation of Homologous Recombination

Monday, March 04 | 8:00AM - 11:15AM
Mechanisms and Control of DNA Repair/Mechanisms of Homologou
s Recombination (Joint)

Room: Van Horne Ballroom A/B

Speaker 7 of 7
Douglas K. Bishop, University of Chicago, USA
Short Talk: Overlapping RAD51-DMC1 foci come in well Separated Pairs: Symmetric Model for Meiotic Recombination

Monday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Monday, March 04 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Monday, March 04 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Monday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: Regulation of DNA Superstructure
Room: Van Horne Ballroom C

Speaker 1 of 8
* Michael M. Cox, University of Wisconsin-Madison, USA

Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: Regulation of DNA Superstructure
Room: Van Horne Ballroom C

Speaker 2 of 8
Erin A. Ronayne, University of Wisconsin, Madison, USA
Structure and Function of the E. coli MgsA Protein

Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: Regulation of DNA Superstructure
Room: Van Horne Ballroom C

Speaker 3 of 8
Manolis Papamichos-Chronakis, Institut Curie, France
Integration of the INO80 Chromatin Remodeling Complex in the Ubiquitin-Mediated Protein Degradation Pathway Is Essential for Genome Stability

Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: Regulation of DNA Superstructure
Room: Van Horne Ballroom C

Speaker 4 of 8
Margaret M. F. Renaud-Young, University of Calgary, Canada
The NuA4 Complex Is a Novel Participant in the Translesion Synthesis Pathway of DNA Post Replication Repair

Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: Regulation of DNA Superstructure
Room: Van Horne Ballroom C

Speaker 5 of 8
Liz Colby, Cancer Research UK, London Research Institute, UK
Creating Site-Specific DNA Damage in S. cerevisiae to Study Replication-Associated Lesion Bypass

Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: Regulation of DNA Superstructure
Room: Van Horne Ballroom C

Speaker 6 of 8
Mariana C. Gadaleta, Drexel University College of Medicine, USA
Swi1 Prevents DNA Damage during Replication of Difficult-to-Replicate Sites

Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: Regulation of DNA Superstructure
Room: Van Horne Ballroom C

Speaker 7 of 8
Diana E. Libuda, University of Oregon, USA
Meiotic Chromosome Structures Constrain and Respond to Designation of Crossover Recombination Sites

Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: Regulation of DNA Superstructure
Room: Van Horne Ballroom C

Speaker 8 of 8
Rebecca C. Burgess, National Cancer Institute, USA
Activation of DNA Damage Response Signaling by Condensed Chromatin

Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: DNA-Damage Checkpoint Signaling
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 1 of 8
* Aaron A. Goodarzi, Southern Alberta Cancer Research Institute, Canada


Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: DNA-Damage Checkpoint Signaling
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 2 of 8
Ralph Scully, Beth Israel Deaconess Medical Center, USA
Dephosphorylation of 53BP1 Is Necessary for its Function in the DNA Damage Response


Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: DNA-Damage Checkpoint Signaling
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 3 of 8
Madalena Tarsounas, University of Oxford, UK
EMBO Young Investigator Presenter: ARF Induces Senescence in Response to DNA Damage by Altering Expression of p53 Targets


Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: DNA-Damage Checkpoint Signaling
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 4 of 8
Michela Di Virgilio, Rockefeller University, USA
Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching


Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: DNA-Damage Checkpoint Signaling
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 5 of 8
J. Ross Chapman, University of Oxford, UK
Rif1: A Critical Regulator of DNA Double-Strand Break Repair Required for Genome Stability and Immune Responses in Mice


Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: DNA-Damage Checkpoint Signaling
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 6 of 8
Kyle M. Miller, USA
Systematic Identification of Functional Residues in Mammalian Histone H2AX


Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: DNA-Damage Checkpoint Signaling
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 7 of 8
Jean-Yves Masson, Laval University Cancer Research Center, Canada
Function of PALB2 in DNA Double-Strand Break Repair and Recombination-Associated DNA Synthesis


Monday, March 04 | 2:30PM - 4:30PM
Workshop 1: DNA-Damage Checkpoint Signaling
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 8 of 8
Simon Bekker-Jensen, University of Copenhagen, Denmark
Human RNF111 Is a Novel SUMO-Targeted Ubiquitin Ligase Functioning in the DNA Damage Response


Monday, March 04 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Monday, March 04 | 5:00PM - 7:00PM
Postreplication Repair/Restart
Room: Van Horne Ballroom C

Speaker 1 of 4
Johannes C. Walter, Harvard Medical School, USA
Mechanisms of Replication-Coupled Crosslink Repair

Monday, March 04 | 5:00PM - 7:00PM
Postreplication Repair/Restart
Room: Van Horne Ballroom C

Speaker 2 of 4
James E. Haber, Brandeis University, USA
Genome Stability and Instability: Repair of a Broken Chromosome

Monday, March 04 | 5:00PM - 7:00PM
Postreplication Repair/Restart
Room: Van Horne Ballroom C

Speaker 3 of 4
* Wei Yang, NIDDK, National Institutes of Health, USA
Translesion DNA Synthesis: Chemistry and Cancer Biology

Monday, March 04 | 5:00PM - 7:00PM
Postreplication Repair/Restart
Room: Van Horne Ballroom C

Speaker 4 of 4
Maria Spies, University of Iowa, USA
Short Talk: Priming Heteroduplex Rejection: hMSH2-hMSH6 Recognizes Mismatches within Recombination Intermediates

Monday, March 04 | 5:00PM - 7:00PM
Chromosomal Stability, Instability and Nuclear Architecture
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 1 of 4
* Alan D. D'Andrea, Dana-Farber Cancer Institute, USA


Monday, March 04 | 5:00PM - 7:00PM
Chromosomal Stability, Instability and Nuclear Architecture
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 2 of 4
Stephen P. Jackson, University of Cambridge, UK
Post-Translational Modifications Controlling the Assembly and Functions of Protein Complexes at DNA Damage Sites


Monday, March 04 | 5:00PM - 7:00PM
Chromosomal Stability, Instability and Nuclear Architecture
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 3 of 4
Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology, France
Nuclear Compartmentalization and DNA Repair: Evidence for Reduced DDR at the Nuclear Periphery


Monday, March 04 | 5:00PM - 7:00PM
Chromosomal Stability, Instability and Nuclear Architecture
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 4 of 4
Ciaran G. Morrison, National University of Ireland, Galway, Ireland
Short Talk: The Pericentriolar Material as a Hub for DNA Damage Checkpoints: Pericentrin and Mcph1 Control Nuclear Chk1 Activation


Monday, March 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Monday, March 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Mezzanine 2


Tuesday, March 05 | 6:45AM - 8:00AM
Breakfast
Room: Mezzanine 2


Tuesday, March 05 | 8:00AM - 11:15AM
Replication Initiation Strategies across Species
Room: Van Horne Ballroom C

Speaker 1 of 6
* Stephen P. Bell, Massachusetts Institute of Technology, USA
Is Helicase Competence Required for Helicase Loading?

Tuesday, March 05 | 8:00AM - 11:15AM
Replication Initiation Strategies across Species
Room: Van Horne Ballroom C

Speaker 2 of 6
Terry L. Orr-Weaver, Massachusetts Institute of Technology, USA
Changes in Gene Copy Number as a Developmental Strategy and DNA Replication Model

Tuesday, March 05 | 8:00AM - 11:15AM
Replication Initiation Strategies across Species
Room: Van Horne Ballroom C

Speaker 3 of 6
Daniel L. Kaplan, Florida State University College of Medicine, USA
Short Talk: Cdc45-ssDNA Interaction Is Important for Stalling the Helicase during Replication Stress

Tuesday, March 05 | 8:00AM - 11:15AM
Replication Initiation Strategies across Species
Room: Van Horne Ballroom C

Speaker 4 of 6
James M. Berger, Johns Hopkins University School of Medicine, USA
Loading and Activation of a Bacterial Hexameric Helicase

Tuesday, March 05 | 8:00AM - 11:15AM
Replication Initiation Strategies across Species
Room: Van Horne Ballroom C

Speaker 5 of 6
J. Julian Blow, University of Dundee, UK
How the Distribution and Regulation of Replication Origins Ensures Precise Chromosome Duplication

Tuesday, March 05 | 8:00AM - 11:15AM
Replication Initiation Strategies across Species
Room: Van Horne Ballroom C

Speaker 6 of 6
Philip Zegerman, University of Cambridge, UK
Short Talk: DNA Replication Initiation Rates Control Cell Cycle Events at the Mid-Blastula Transition of Xenopus laevis

Tuesday, March 05 | 8:00AM - 11:15AM
Controlling DNA Damage Responses by Ubiquitylation and Sumoy
lation
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 1 of 7
* Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada
The Mystery of 53BP1 Recruitment


Tuesday, March 05 | 8:00AM - 11:15AM
Controlling DNA Damage Responses by Ubiquitylation and Sumoy
lation
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 2 of 7
Dana Branzei, FIRC Institute of Molecular Oncology, Italy
A SUMO-Dependent Chromatin Architectural Pathway Facilitates Error-Free DNA Damage Tolerance via Sister Chromatid Recombination


Tuesday, March 05 | 8:00AM - 11:15AM
Controlling DNA Damage Responses by Ubiquitylation and Sumoy
lation
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 3 of 7
Kristijan Ramadan, University of Oxford, UK
Short Talk: Premature Aging Syndrome in Human Is Caused by Mutations in p97/VCP-Cofactor DVC1/Spartan


Tuesday, March 05 | 8:00AM - 11:15AM
Controlling DNA Damage Responses by Ubiquitylation and Sumoy
lation
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 4 of 7
Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
The Importance of UBCZ Domains


Tuesday, March 05 | 8:00AM - 11:15AM
Controlling DNA Damage Responses by Ubiquitylation and Sumoy
lation
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 5 of 7
Petra Beli, Novo Nordisk Foundation Center for Protein Research, Denmark
Short Talk: Systems-Wide Analysis of Ubiquitylation in Response to UV


Tuesday, March 05 | 8:00AM - 11:15AM
Controlling DNA Damage Responses by Ubiquitylation and Sumoy
lation
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 6 of 7
Titia K. Sixma, Netherlands Cancer Institute, Netherlands
Short Talk: RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling


Tuesday, March 05 | 8:00AM - 11:15AM
Controlling DNA Damage Responses by Ubiquitylation and Sumoy
lation
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 7 of 7
Jacqueline J. Jacobs, Netherlands Cancer Institute, Netherlands
EMBO Young Investigator Short Talk: New Factors Controlling Telomere-Driven Genomic Instability


Tuesday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Tuesday, March 05 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Tuesday, March 05 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Tuesday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 2: DNA Repair/Recombination Processes
Room: Van Horne Ballroom A/B

Speaker 1 of 7
* Marc S. Wold, University of Iowa, USA
New Insights into Repair-Specific Roles of Replication Protein A

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 2: DNA Repair/Recombination Processes
Room: Van Horne Ballroom A/B

Speaker 2 of 7
Andrea Regier Voth, NIDDK, National Institutes of Health, USA
Structural Characterization of the Molecular Mechanism of the DNA Transposase Hermes

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 2: DNA Repair/Recombination Processes
Room: Van Horne Ballroom A/B

Speaker 3 of 7
Kayleigh Wardell, University of Sussex, UK
RcrA, a Novel Protein at the Crossroads of Replication and Recombination

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 2: DNA Repair/Recombination Processes
Room: Van Horne Ballroom A/B

Speaker 4 of 7
Jordan R. Becker, University of Minnesota, USA
Ubiquitinated PCNA Monitors Okazaki Fragment Processing

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 2: DNA Repair/Recombination Processes
Room: Van Horne Ballroom A/B

Speaker 5 of 7
Sabine S. Lange, University of Texas MD Anderson Cancer Center, USA
Dual Role for Mammalian DNA Polymerase Zeta in Supporting Proliferative Responses and Maintaining Genome Stability

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 2: DNA Repair/Recombination Processes
Room: Van Horne Ballroom A/B

Speaker 6 of 7
Robin N. Eichmiller, State University of New York, Buffalo, USA
Mutations in RAD1 Reveal Altered Regulation of Rad1-Rad10 Activity

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 2: DNA Repair/Recombination Processes
Room: Van Horne Ballroom A/B

Speaker 7 of 7
Georgios I. Karras, Whitehead Institute for Biomedical Research, USA
Non-Canonical Role of the 9-1-1 Clamp in the Error-Free DNA Damage Tolerance Pathway

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 3: DNA Replication Processes
Room: Van Horne Ballroom C

Speaker 1 of 7
* Michael A. Trakselis, Baylor University, USA
Formation of an Archaeal Primosome Complex Controls DNA Priming and Unwinding

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 3: DNA Replication Processes
Room: Van Horne Ballroom C

Speaker 2 of 7
Arek Kulczyk, Harvard Medical School, USA
Single-Molecule Studies of the Replisome Structure and Dynamics

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 3: DNA Replication Processes
Room: Van Horne Ballroom C

Speaker 3 of 7
Ian M. Slaymaker, University of Southern California, USA
Mini-Chromosome Maintenance Complexes Form a Filament to Remodel DNA Structure and Topology

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 3: DNA Replication Processes
Room: Van Horne Ballroom C

Speaker 4 of 7
Juan Méndez, Spanish National Cancer Research Centre, Spain
PrimPol, a New Human DNA Primase/Polymerase, Is Involved in Translesion Synthesis and Recovery of Stalled Forks during Nuclear DNA Replication

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 3: DNA Replication Processes
Room: Van Horne Ballroom C

Speaker 5 of 7
Lindsey N. Williams, University of Washington, USA
Checkpoint-Dependent Mutagenesis by Error-Prone DNA Polymerase epsilon Variants

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 3: DNA Replication Processes
Room: Van Horne Ballroom C

Speaker 6 of 7
Kin Fan On, London Research Institute, Clare Hall Laboratories, UK
A Cell-Free DNA Replication System Using Pre-RCs Reconstituted with Purified Proteins

Tuesday, March 05 | 2:30PM - 4:30PM
Workshop 3: DNA Replication Processes
Room: Van Horne Ballroom C

Speaker 7 of 7
Viola Nähse-Kumpf, Institute for Cancer Research, Norwegian Radium Hospital, Norway
Checkpoint Kinase WEE1 Protects Against Replication-Associated DNA Damage

Tuesday, March 05 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, March 05 | 5:00PM - 7:15PM
Replication, Chromatin and Genome Instability (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 6
* Sophie E. Polo, Paris Diderot University, France

Tuesday, March 05 | 5:00PM - 7:15PM
Replication, Chromatin and Genome Instability (Joint)
Room: Van Horne Ballroom A/B

Speaker 2 of 6
Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Chromatin Assembly from Nucleosome to Heterochromatin: The Issue of DNA Damage and Genome Instability

Tuesday, March 05 | 5:00PM - 7:15PM
Replication, Chromatin and Genome Instability (Joint)
Room: Van Horne Ballroom A/B

Speaker 3 of 6
Ian D. Hickson, University of Copenhagen, Denmark
Resolution of Stalled Replication Forks and Late Replication Intermediates

Tuesday, March 05 | 5:00PM - 7:15PM
Replication, Chromatin and Genome Instability (Joint)
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
The Spatial Dynamics of Repair

Tuesday, March 05 | 5:00PM - 7:15PM
Replication, Chromatin and Genome Instability (Joint)
Room: Van Horne Ballroom A/B

Speaker 5 of 6
Jennifer A. Cobb, University of Calgary, Canada
Short Talk: Nej1 C-Terminus Is Critical for Efficient Nonhomologous End-Joining in S. cerevisiae

Tuesday, March 05 | 5:00PM - 7:15PM
Replication, Chromatin and Genome Instability (Joint)
Room: Van Horne Ballroom A/B

Speaker 6 of 6
Brendan D. Price, Dana-Farber Cancer Institute, USA
Short Talk: Histone H2A.Z Regulates Chromatin Structure and End-Resection by CtIP at DSBs

Tuesday, March 05 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Mezzanine 2


Tuesday, March 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Mezzanine 2


Wednesday, March 06 | 6:45AM - 8:00AM
Breakfast
Room: Mezzanine 2


Wednesday, March 06 | 8:00AM - 11:15AM
Genome Structure and Maintenance
Room: Van Horne Ballroom C

Speaker 1 of 6
* Lorraine S. Symington, Columbia University, USA
RPA Coordinates DNA End Resection and Prevents Formation of Hairpins

Wednesday, March 06 | 8:00AM - 11:15AM
Genome Structure and Maintenance
Room: Van Horne Ballroom C

Speaker 2 of 6
* Simon J. Boulton, Francis Crick Institute, UK
Replication Blocking Lesions. HelQ: Role in DNA Repair

Wednesday, March 06 | 8:00AM - 11:15AM
Genome Structure and Maintenance
Room: Van Horne Ballroom C

Speaker 3 of 6
Massimo Lopes, University of Zürich, Switzerland
EMBO Young Investigator Short Talk: Remodelling of Replication Intermediates upon DNA Replication Stress

Wednesday, March 06 | 8:00AM - 11:15AM
Genome Structure and Maintenance
Room: Van Horne Ballroom C

Speaker 4 of 6
Stephen C. West, Francis Crick Institute, UK
Alternative Pathways for Holliday Junction Resolution in Human Cells

Wednesday, March 06 | 8:00AM - 11:15AM
Genome Structure and Maintenance
Room: Van Horne Ballroom C

Speaker 5 of 6
Akira Shinohara, Osaka University, Japan
Control of Meiotic Recombination by Rad51 Mediators and DNA Helicases

Wednesday, March 06 | 8:00AM - 11:15AM
Genome Structure and Maintenance
Room: Van Horne Ballroom C

Speaker 6 of 6
Gary Karpen, University of California, Berkeley, USA
Short Talk: Heterochromatin and Nuclear Pore Proteins Regulate the Spatial and Temporal Dynamics of Recombination Repair among Repeated DNAs

Wednesday, March 06 | 8:00AM - 11:15AM
Genome Instability, Telomeres, Disease and Aging. Session sp
onsored by The Ellison Medical Foundation.
This session is from Genomic Instability

Room: Van Horne Ballroom A/B
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 1 of 7
* Susan P. Lees-Miller, University of Calgary, Canada


Wednesday, March 06 | 8:00AM - 11:15AM
Genome Instability, Telomeres, Disease and Aging. Session sp
onsored by The Ellison Medical Foundation.
This session is from Genomic Instability

Room: Van Horne Ballroom A/B
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 2 of 7
Titia de Lange, Rockefeller University, USA
TRF2 Promotes T-Loop Formation to Block ATM Signaling and NHEJ at Chromosome Ends


Wednesday, March 06 | 8:00AM - 11:15AM
Genome Instability, Telomeres, Disease and Aging. Session sp
onsored by The Ellison Medical Foundation.
This session is from Genomic Instability

Room: Van Horne Ballroom A/B
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 3 of 7
André Nussenzweig, NCI, National Institutes of Health, USA
Identification of a Novel Class of Early Replicating Fragile Sites that Contribute to Genomic Instability in B Cell Lymphomas


Wednesday, March 06 | 8:00AM - 11:15AM
Genome Instability, Telomeres, Disease and Aging. Session sp
onsored by The Ellison Medical Foundation.
This session is from Genomic Instability

Room: Van Horne Ballroom A/B
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 4 of 7
Catherine H. Freudenreich, Tufts University, USA
Short Talk: Regulation of Acetylation on the Histone H4 Tail Maintains Fidelity of Homologous Recombination and Prevents CAG Expansions


Wednesday, March 06 | 8:00AM - 11:15AM
Genome Instability, Telomeres, Disease and Aging. Session sp
onsored by The Ellison Medical Foundation.
This session is from Genomic Instability

Room: Van Horne Ballroom A/B
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 5 of 7
Laura J. Niedernhofer, The Scripps Research Institute, USA
The Mechanism by which DNA Repair Protects Against Aging


Wednesday, March 06 | 8:00AM - 11:15AM
Genome Instability, Telomeres, Disease and Aging. Session sp
onsored by The Ellison Medical Foundation.
This session is from Genomic Instability

Room: Van Horne Ballroom A/B
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 6 of 7
Keith W. Caldecott, University of Sussex, UK
Topoisomerase-Induced DNA Double Strand Breakage and Repair in Human Disease


Wednesday, March 06 | 8:00AM - 11:15AM
Genome Instability, Telomeres, Disease and Aging. Session sp
onsored by The Ellison Medical Foundation.
This session is from Genomic Instability

Room: Van Horne Ballroom A/B
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 7 of 7
Carl L. Schildkraut, Albert Einstein College of Medicine, USA
Short Talk: DNA Replication Fork Progression through the Fragile X and Telomere Repeats


Wednesday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Wednesday, March 06 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Wednesday, March 06 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Wednesday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Wednesday, March 06 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, March 06 | 5:00PM - 7:00PM
Topological Transformations in DNA
Room: Van Horne Ballroom C

Speaker 1 of 4
* Phoebe A. Rice, University of Chicago, USA
The How, When and Where of Site-Specific DNA Recombination

Wednesday, March 06 | 5:00PM - 7:00PM
Topological Transformations in DNA
Room: Van Horne Ballroom C

Speaker 2 of 4
Camilla Sjögren, Karolinska Institutet, Sweden
Sister Chromatid Intertwinings and the SMC Complexes

Wednesday, March 06 | 5:00PM - 7:00PM
Topological Transformations in DNA
Room: Van Horne Ballroom C

Speaker 3 of 4
Claire Wyman, Erasmus Medical Center, Netherlands
The 'See Me, Feel Me' Approach to Understand Key Steps in Homologous Recombination

Wednesday, March 06 | 5:00PM - 7:00PM
Topological Transformations in DNA
Room: Van Horne Ballroom C

Speaker 4 of 4
Jon Baxter, University of Sussex, UK
Short Talk: The Yeast Pif1 Family Helicase RRM3 Promotes DNA Unwinding during Replication Fork Swiveling

Wednesday, March 06 | 5:00PM - 7:00PM
DNA Damage and Links to Transcription, RNA Metabolism and Ot
her Processes
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 1 of 6
* David Cortez, Vanderbilt University School of Medicine, USA


Wednesday, March 06 | 5:00PM - 7:00PM
DNA Damage and Links to Transcription, RNA Metabolism and Ot
her Processes
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 2 of 6
Andrés Aguilera, University of Seville, CABIMER, Spain
Mechanisms of Transcription- and RNA-Induced DNA Damage and Genome Instability


Wednesday, March 06 | 5:00PM - 7:00PM
DNA Damage and Links to Transcription, RNA Metabolism and Ot
her Processes
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 3 of 6
Karlene A. Cimprich, Stanford University, USA
Novel Mechanisms for Maintaining Genome Stability


Wednesday, March 06 | 5:00PM - 7:00PM
DNA Damage and Links to Transcription, RNA Metabolism and Ot
her Processes
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 4 of 6
Scott R. Floyd, Duke University, USA
Short Talk: Linking Chromatin State to Signaling Networks in the DDR


Wednesday, March 06 | 5:00PM - 7:00PM
DNA Damage and Links to Transcription, RNA Metabolism and Ot
her Processes
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 5 of 6
Uttiya Basu, USA
Short Talk: B Cell Genome Mutator AID Is Regulated in the RNA Polymerase II Associated Transcriptional Complex by E3-Ubiquitin Ligase NEDD4


Wednesday, March 06 | 5:00PM - 7:00PM
DNA Damage and Links to Transcription, RNA Metabolism and Ot
her Processes
This session is from Genomic Instability

Room: Van Horne Ballroom A/B

Speaker 6 of 6
Manuel Stucki, University of Zurich, Switzerland
Short Talk: NBS1 and the Nucleolar Response to DNA Double-Strand Breaks


Wednesday, March 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Wednesday, March 06 | 7:30PM - 10:00PM
Poster Session 3
Room: Mezzanine 2


Thursday, March 07 | 6:45AM - 8:00AM
Breakfast
Room: Mezzanine 2


Thursday, March 07 | 7:30AM - 8:00AM
Poster Setup
Room: Mezzanine 2


Thursday, March 07 | 8:00AM - 5:00PM
Poster Viewing
Room: Mezzanine 2


Thursday, March 07 | 8:00AM - 11:15AM
Replication Elongation Machineries
Room: Van Horne Ballroom C

Speaker 1 of 6
David J. Sherratt, University of Oxford, UK
High-Resolution in vivo Analysis of Bacterial Chromosome Replication and Recombination

Thursday, March 07 | 8:00AM - 11:15AM
Replication Elongation Machineries
Room: Van Horne Ballroom C

Speaker 2 of 6
* Peter M. Burgers, Washington University School of Medicine, USA
Connecting DNA Damage to Checkpoint Initiation

Thursday, March 07 | 8:00AM - 11:15AM
Replication Elongation Machineries
Room: Van Horne Ballroom C

Speaker 3 of 6
John A. Tainer, The Scripps Research Institute, USA
Short Talk: MRE11 Complex Regulates Repair Pathway Choice as Shown by Chemical Knockdown of Specific Activities

Thursday, March 07 | 8:00AM - 11:15AM
Replication Elongation Machineries
Room: Van Horne Ballroom C

Speaker 4 of 6
Stephen D. Bell, Indiana University, USA
The Okazakisome

Thursday, March 07 | 8:00AM - 11:15AM
Replication Elongation Machineries
Room: Van Horne Ballroom C

Speaker 5 of 6
Linda B. Bloom, University of Florida, USA
Clamp Loading Mechanisms

Thursday, March 07 | 8:00AM - 11:15AM
Replication Elongation Machineries
Room: Van Horne Ballroom C

Speaker 6 of 6
Nicholas E. Dixon, University of Wollongong, Australia
Short Talk: An epsilon-beta Interaction in E. coli DNA Polymerase III Stabilizes the Replicase in the Polymerization Mode

Thursday, March 07 | 8:00AM - 11:00AM
Genomic and Genome-Wide Studies
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 1 of 7
* Karlene A. Cimprich, Stanford University, USA


Thursday, March 07 | 8:00AM - 11:00AM
Genomic and Genome-Wide Studies
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 2 of 7
Michael Stratton, Wellcome Trust Sanger Institute, UK
Signatures of Mutational Processes Operative in Human Cancers


Thursday, March 07 | 8:00AM - 11:00AM
Genomic and Genome-Wide Studies
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 3 of 7
David Cortez, Vanderbilt University School of Medicine, USA
Identification and Characterization of Mammalian Genome Maintenance Proteins


Thursday, March 07 | 8:00AM - 11:00AM
Genomic and Genome-Wide Studies
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 4 of 7
Ryan L. Ragland, Perelman School of Medicine, University of Pennsylvania, USA
Short Talk: Genome-Wide Identification of Replication-Associated Breakpoints


Thursday, March 07 | 8:00AM - 11:00AM
Genomic and Genome-Wide Studies
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 5 of 7
Marcel Tijsterman, Leiden University Medical Center, Netherlands
Pol theta Mediated end Joining of DNA Breaks Induced by Replication Fork Barriers


Thursday, March 07 | 8:00AM - 11:00AM
Genomic and Genome-Wide Studies
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 6 of 7
Peter C. Stirling, University of British Columbia, Canada
Short Talk: Systematic Genetic and Cytological Analysis of Genome Integrity Pathways in Yeast


Thursday, March 07 | 8:00AM - 11:00AM
Genomic and Genome-Wide Studies
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 7 of 7
Gaëlle Legube, Center for Integrative Biology, France
Short Talk: Transcription Channels DNA Double Strand Breaks to a RAD51-Dependent Repair Pathway


Thursday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Thursday, March 07 | 11:15AM - 12:00PM
Lunch
Room: Mezzanine 2


Thursday, March 07 | 12:00PM - 2:30PM
Poster Session 4
Room: Mezzanine 2


Thursday, March 07 | 2:30PM - 4:30PM
Workshop 4: Enzymes Acting on Nucleic Acids
Room: Van Horne Ballroom C

Speaker 1 of 7
* John L. Nitiss, University of Illinois, USA
A Mutation in Eukaryotic Topoisomerase II that Mimics the Action of Topoisomerase Poisons: Role of the C-Terminal Dimerization Domain in
Regulation of DNA Cleavage


Thursday, March 07 | 2:30PM - 4:30PM
Workshop 4: Enzymes Acting on Nucleic Acids
Room: Van Horne Ballroom C

Speaker 2 of 7
Ilya J. Finkelstein, University of Texas at Austin, USA
Single Molecule Imaging Reveals the Mechanisms of Roadblock Clearance by DNA-Binding Motor Enzymes

Thursday, March 07 | 2:30PM - 4:30PM
Workshop 4: Enzymes Acting on Nucleic Acids
Room: Van Horne Ballroom C

Speaker 3 of 7
Aaron C. Mason, Vanderbilt University, USA
Structural Insight into the Mechanism of the DNA Damage Response Protein Smarcal1

Thursday, March 07 | 2:30PM - 4:30PM
Workshop 4: Enzymes Acting on Nucleic Acids
Room: Van Horne Ballroom C

Speaker 4 of 7
Hannah E. Mischo, Clare Hall Laboratories, London Research Institute, UK
Connections between Transcription Termination and Genome Integrity: Dissecting the Function of the Superfamily I Helicase Sen1

Thursday, March 07 | 2:30PM - 4:30PM
Workshop 4: Enzymes Acting on Nucleic Acids
Room: Van Horne Ballroom C

Speaker 5 of 7
Alessandro Vindigni, St. Louis University, USA
Mechanistic Insight into Replication Fork Reversal and Restart Under Genotoxic Stress

Thursday, March 07 | 2:30PM - 4:30PM
Workshop 4: Enzymes Acting on Nucleic Acids
Room: Van Horne Ballroom C

Speaker 6 of 7
Alessandro Costa, Francis Crick Institute, UK
Structure of the Bloom's Complex: Insights into the Mechanism of Double Holliday Junction Dissolution

Thursday, March 07 | 2:30PM - 4:30PM
Workshop 4: Enzymes Acting on Nucleic Acids
Room: Van Horne Ballroom C

Speaker 7 of 7
Sarah Wessel, University of Wisconsin, USA
Molecular Interactions in PriC-Mediated DNA Replication Restart

Thursday, March 07 | 2:30PM - 4:30PM
Workshop 2: DNA DSB Repair and Associated Processes
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 1 of 9
* Ralph Scully, Beth Israel Deaconess Medical Center, USA


Thursday, March 07 | 2:30PM - 4:30PM
Workshop 2: DNA DSB Repair and Associated Processes
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 2 of 9
Katheryn D. Meek, Michigan State University, USA
Unraveling the Complexities of DNA-PK Autophosphorylation


Thursday, March 07 | 2:30PM - 4:30PM
Workshop 2: DNA DSB Repair and Associated Processes
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 3 of 9
Alessandro A. Sartori, Institute of Molecular Cancer Research, Switzerland
The Human PIN1 Isomerase Regulates DSB Repair


Thursday, March 07 | 2:30PM - 4:30PM
Workshop 2: DNA DSB Repair and Associated Processes
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 4 of 9
Jacques Côté, Laval University Cancer Research Center, Canada
Phospho-Dependent Recruitment of NuA4 by MRX at DNA Breaks Regulates RPA Dynamics during Resection


Thursday, March 07 | 2:30PM - 4:30PM
Workshop 2: DNA DSB Repair and Associated Processes
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 5 of 9
Lei Li, University of Alberta, Canada
DEAD Box 1 Interacts with Rif1 and Promotes Homologous DNA Repair


Thursday, March 07 | 2:30PM - 4:30PM
Workshop 2: DNA DSB Repair and Associated Processes
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 6 of 9
Martin A. M. Reijns, MRC Institute for Genetics and Molecular Medicine, UK
Ribonuclease H2 Is Essential for the Removal of Misincorporated Ribonucleotides and for Mammalian Genome Integrity


Thursday, March 07 | 2:30PM - 4:30PM
Workshop 2: DNA DSB Repair and Associated Processes
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 7 of 9
David O. Ferguson, University of Michigan Medical School, USA
Mre11 Interacts with Cyclin-Dependent Kinase 2 to Regulate Double Strand Break Repair


Thursday, March 07 | 2:30PM - 4:30PM
Workshop 2: DNA DSB Repair and Associated Processes
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 8 of 9
Nidhi Nair, University of Dundee, UK
Slx1 and Mus81 Nucleases Cooperate in Holliday Junction Resolution


Thursday, March 07 | 2:30PM - 4:30PM
Workshop 2: DNA DSB Repair and Associated Processes
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 9 of 9
Priscilla K. Cooper, Environment Mutagen Society, USA
XPG Partners with BRCA2 to Promote Homologous Recombination and Maintain Genome Stability


Thursday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, March 07 | 5:00PM - 7:00PM
Replicating Challenging Regions
Room: Van Horne Ballroom C

Speaker 1 of 4
* Virginia A. Zakian, Princeton University, USA
Conservation of Functions in Pif1 Family Helicases

Thursday, March 07 | 5:00PM - 7:00PM
Replicating Challenging Regions
Room: Van Horne Ballroom C

Speaker 2 of 4
Joachim Lingner, École Polytechnique Fédérale de Lausanne, Switzerland
The THO Complex Counteracts Telomeric R-Loops and Telomere Instability

Thursday, March 07 | 5:00PM - 7:00PM
Replicating Challenging Regions
Room: Van Horne Ballroom C

Speaker 3 of 4
Maria Teresa Teixeira, CNRS – UMR 8226, France
Short Talk: The DNA End Replication Problem and the Establishment of Replicative Senescence in Saccharomyces cerevisiae

Thursday, March 07 | 5:00PM - 7:00PM
Replicating Challenging Regions
Room: Van Horne Ballroom C

Speaker 4 of 4
Julia Promisel Cooper, NCI, National Institutes of Health, USA
Solving the End Replication and Protection Problems without Telomerase or Telomere Repeats

Thursday, March 07 | 5:00PM - 7:15PM
Diagnostic and Therapeutic Applications
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 1 of 6
* Stephen P. Jackson, University of Cambridge, UK


Thursday, March 07 | 5:00PM - 7:15PM
Diagnostic and Therapeutic Applications
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 2 of 6
Thomas Helleday, Karolinska Institutet, Sweden
Therapeutic Strategies for Cancer Based on DNA Repair Inhibition


Thursday, March 07 | 5:00PM - 7:15PM
Diagnostic and Therapeutic Applications
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 3 of 6
Jos Jonkers, Netherlands Cancer Institute, Netherlands
DDR-Based Therapeutic Strategies and Resistance Mechanisms


Thursday, March 07 | 5:00PM - 7:15PM
Diagnostic and Therapeutic Applications
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Óscar Fernández-Capetillo, Spanish National Cancer Research Centre, Spain
Exploring the Role of Replicative Stress in Cancer and Aging


Thursday, March 07 | 5:00PM - 7:15PM
Diagnostic and Therapeutic Applications
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 5 of 6
Yves G. Pommier, NCI, National Institutes of Health, USA
Short Talk: PARP1-TDP1 Partnership for DNA Repair and Processing of Top1-DNA Complexes


Thursday, March 07 | 5:00PM - 7:15PM
Diagnostic and Therapeutic Applications
This session is from Genomic Instability
Room: Van Horne Ballroom A/B

Speaker 6 of 6
Michael Weinfeld, University of Alberta, Canada
Short Talk: Synthetic Lethality through Targeted Disruption of Polynucleotide Kinase/Phosphatase


Thursday, March 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Thursday, March 07 | 8:00PM - 11:00PM
Entertainment
Room: Mezzanine 2


Thursday, March 07 | 8:00PM - 11:00PM
Cash Bar
Room: Mezzanine 2


Friday, March 08 | 10:25AM - 10:25AM
Departure


*Session Chair.